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Found 428 Enz. Inhib. hit(s) with Target = 'Ribosomal protein S6 kinase alpha-5'
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)
Affinity DataKi:  94nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)
Affinity DataKi:  990nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50341519((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50463484(CHEMBL4248525)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)
Affinity DataKi: >1.89E+3nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705)
Affinity DataKi:  8.90E+5nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Affinity DataKi:  1.70E+6nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601136(CHEMBL5177437)
Affinity DataIC50:  0.251nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.426nMAssay Description:Inhibition of human MSK1 using GRPRTSSFAEG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM24996(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM259876(US9505766, 81)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of N-terminal His-Smt-tagged MSK1 C-terminal kinase domain (414 to 738 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3)...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM24994(4-[1-ethyl-7-(piperidin-4-ylmethoxy)-1H-imidazo[4,...)
Affinity DataIC50:  1nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168854(4-(1-Ethyl-7-piperazin-1-ylmethyl-1H-imidazo[4,5-c...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MSK1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human MSK1 using GRPRTSSFAEG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168577(4-(1-Cyclopropyl-1H-imidazo[4,5-c]pyridin-2-yl)-fu...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168577(4-(1-Cyclopropyl-1H-imidazo[4,5-c]pyridin-2-yl)-fu...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168858((R,S)-4-(1-Piperidin-3-yl-1H-imidazo[4,5-c]pyridin...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168856(4-[1-(3-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyrid...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168587(4-(1-Cyclohexyl-1H-imidazo[4,5-c]pyridin-2-yl)-fur...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM24991(4-(7-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-1-eth...)
Affinity DataIC50:  3nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168587(4-(1-Cyclohexyl-1H-imidazo[4,5-c]pyridin-2-yl)-fur...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168869(1-[2-(4-Amino-furazan-3-yl)-1-ethyl-1H-imidazo[4,5...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168861(4-(4-Chloro-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50431812(CHEMBL2347053)
Affinity DataIC50:  4nMAssay Description:Inhibition of MSK1 (unknown origin) after 10 mins by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168862(4-[1-(4-Aminomethyl-phenyl)-1H-imidazo[4,5-c]pyrid...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM259876(US9505766, 81)
Affinity DataIC50:  5nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168581(4-(1-Phenyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50560259(CHEMBL4792347)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of human MSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168853(4-(1-Ethyl-7-piperidin-1-ylmethyl-1H-imidazo[4,5-c...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM3175(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Affinity DataIC50:  8nMAssay Description:Inhibition of His-tagged human MSK1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM24996(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Affinity DataIC50:  8nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168866(4-(1-Ethyl-4-methyl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168864((R,S)-4-[1-(2-Amino-1-methyl-ethyl)-1H-imidazo[4,5...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168867(4-(7-Bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-...)
Affinity DataIC50:  9nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601139(CHEMBL5190298)
Affinity DataIC50:  10nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM24993(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-(piperi...)
Affinity DataIC50:  11nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168581(4-(1-Phenyl-1H-imidazo[4,5-c]pyridin-2-yl)-furazan...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM24995(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-(piperi...)
Affinity DataIC50:  13nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168578(4-[1-(1-Amino-butyl)-1H-imidazo[4,5-c]pyridin-2-yl...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601138(CHEMBL5184056)
Affinity DataIC50:  13nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168868(4-[1-(4-Amino-butyl)-1H-imidazo[4,5-c]pyridin-2-yl...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50:  14nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM24990(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-N-[2-(met...)
Affinity DataIC50:  15nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168594(2-(4-Amino-furazan-3-yl)-1-ethyl-1H-benzoimidazol-...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168601(4-(1-Piperidin-4-yl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50168601(4-(1-Piperidin-4-yl-1H-imidazo[4,5-c]pyridin-2-yl)...)
Affinity DataIC50:  17nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50601158(CHEMBL5186781)
Affinity DataIC50:  20nMAssay Description:Inhibition of full-length N-terminal His-TEV-tagged inactive form of MSK1 (2 to 802 residues) (unknown origin) expressed in HEK293 cells using FAM-PS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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