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Found 14 Enz. Inhib. hit(s) with Target = 'Sodium/hydrogen exchanger 2'
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50104844(BMS-284640 | CHEMBL51879 | N-[(1R,3R)-3-(2,3-Dihyd...)
Affinity DataIC50:  1.80E+3nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097897(CHEMBL352933 | N-(5-Methyl-1-phenyl-1H-pyrazole-4-...)
Affinity DataIC50:  3.90E+3nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50191831(5-(4-fluoro-3-methylphenyl)-2-methoxy-4-(4-(4-meth...)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058715(CHEMBL64360 | EMD-96785 | ENIPORIDE | N-(5-Methane...)
Affinity DataIC50:  9.20E+3nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097898(CHEMBL355862 | N-(5-Cyclopropyl-1-quinolin-5-yl-1H...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097895(CHEMBL355071 | N-(5-Cyclopropyl-1-phenyl-1H-pyrazo...)
Affinity DataIC50:  1.28E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097896(CHEMBL354137 | N-(5-Cyclopropyl-1-naphthalen-1-yl-...)
Affinity DataIC50:  1.63E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058715(CHEMBL64360 | EMD-96785 | ENIPORIDE | N-(5-Methane...)
Affinity DataIC50:  1.70E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058715(CHEMBL64360 | EMD-96785 | ENIPORIDE | N-(5-Methane...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Is...)
Affinity DataIC50:  2.87E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Is...)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Is...)
Affinity DataIC50:  6.20E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50196789(CHEMBL3892788)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human NHE2 expressed in LAP1 cell assessed as intracellular pH recovery measured for 2 mins by CECF-AM dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50097899(CHEMBL167495 | N-(5-Methyl-1-quinolin-5-yl-1H-pyra...)
Affinity DataIC50:  4.16E+5nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed