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Found 394 Enz. Inhib. hit(s) with Target = 'Sphingomyelin phosphodiesterase'
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122309(((3S,4R)-1,1-Difluoro-3-hexadecanoylamino-4-hydrox...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity of the compound against schyphostatin of neutral sphingomyelinase (N-SMase) from bovine brain microsomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520425(CHEMBL4556453)
Affinity DataKi:  7.00E+4nMAssay Description:Inhibition of acid sphingomyelinase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 2(Homo sapiens (Human))
Tokyo University Of Pharmacy & Life Science

Curated by ChEMBL
LigandPNGBDBM50122310(((2R,3R,4R)-1,1-Difluoro-3-hexadecanoylamino-2,4-d...)
Affinity DataKi:  2.53E+5nMAssay Description:Inhibitory activity against neutral sphingomyelinase (N-SMase) from bovine brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521402(CHEMBL4471834)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521405(CHEMBL4551018)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521404(CHEMBL4449307)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM67506(4-(4,5-diphenyl-1,3-dihydroimidazol-2-ylidene)-2,6...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50520416(CHEMBL4553570)
Affinity DataIC50:  20nMAssay Description:Inhibition of acid sphingomyelinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521420(CHEMBL4467223)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521425(CHEMBL4449305)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50370179(CHEMBL4163007)
Affinity DataIC50:  20nMAssay Description:Inhibition of acid sphingomyelinase in human HuH7 cell lysate using NBD-sphingomyelin as substrate after 30 mins by TLC based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521419(CHEMBL1342201)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521419(CHEMBL1342201)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521413(CHEMBL4565746)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521406(CHEMBL4458407)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540386(CHEMBL4647644 | US11427590, Entry 44)
Affinity DataIC50:  50nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM570145(US11427590, Entry 62)
Affinity DataIC50:  50nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521408(CHEMBL4468906)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540386(CHEMBL4647644 | US11427590, Entry 44)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521428(CHEMBL4471548)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521407(CHEMBL4577390)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50370125(CHEMBL4176817)
Affinity DataIC50:  70nMAssay Description:Inhibition of acid sphingomyelinase in human HuH7 cell lysate using NBD-sphingomyelin as substrate after 30 mins by TLC based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521427(CHEMBL4533205)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521399(CHEMBL4588691)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540378(CHEMBL4634085 | US11427590, Entry 22)
Affinity DataIC50:  90nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521421(CHEMBL4514045)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540378(CHEMBL4634085 | US11427590, Entry 22)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540366(CHEMBL4635335 | US11427590, Entry 37)
Affinity DataIC50:  100nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540363(CHEMBL4643888 | US11427590, Entry 32)
Affinity DataIC50:  100nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540383(CHEMBL4635273 | US11427590, Entry 25)
Affinity DataIC50:  100nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540376(CHEMBL4644091 | US11427590, Entry 24)
Affinity DataIC50:  100nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM570104(US11427590, Entry 21)
Affinity DataIC50:  100nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540383(CHEMBL4635273 | US11427590, Entry 25)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540376(CHEMBL4644091 | US11427590, Entry 24)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540366(CHEMBL4635335 | US11427590, Entry 37)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540363(CHEMBL4643888 | US11427590, Entry 32)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521430(CHEMBL4573101)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521412(CHEMBL4540577)
Affinity DataIC50:  120nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50521429(CHEMBL4436316)
Affinity DataIC50:  130nMAssay Description:Inhibition of human recombinant nSMase expressed in HEK293 cells using sphingomyelin as substrate by alkaline phosphatase, choline oxidase and horser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540356(CHEMBL4632464 | US11427590, Entry 17)
Affinity DataIC50:  200nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540349(CHEMBL4648675 | US11427590, Entry 9)
Affinity DataIC50:  200nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540384(CHEMBL4644595)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540382(CHEMBL4640034 | US11427590, Entry 23)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540381(CHEMBL4632415 | US11427590, Entry 30)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540369(CHEMBL4632713 | US11427590, Entry 19)
Affinity DataIC50:  200nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540382(CHEMBL4640034 | US11427590, Entry 23)
Affinity DataIC50:  200nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540365(CHEMBL4633254 | US11427590, Entry 34)
Affinity DataIC50:  200nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540381(CHEMBL4632415 | US11427590, Entry 30)
Affinity DataIC50:  200nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540372(CHEMBL4648184 | US11427590, Entry 42)
Affinity DataIC50:  200nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
Johns Hopkins University

Curated by ChEMBL
LigandPNGBDBM50540372(CHEMBL4648184 | US11427590, Entry 42)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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