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Found 997 Enz. Inhib. hit(s) with Target = 'Synaptic vesicular amine transporter'
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity to VMAT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.240nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611939((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-{[(1R,2R)- ...)
Affinity DataKi:  0.290nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611952((2R,3R,11bR)-9- (cyclobutylmethoxy)-3-(2,2- dimeth...)
Affinity DataKi:  0.290nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301022((+)-9-fluoropropyl-dihydrotetrabenazine | CHEMBL57...)
Affinity DataKi:  0.360nMAssay Description:Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611867(1-(2-{[(2R,3R,11bR)-3-(2,2- dimethylpropyl)-2-hydr...)
Affinity DataKi:  0.410nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611873((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-(3- fluorop...)
Affinity DataKi:  0.480nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611905((2R,3R,11bR)-3-(2,2- dimethylpropyl)-10-methoxy- 9...)
Affinity DataKi:  0.520nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611877((2R,3R,11bR)-9-cyclobutoxy- 3-(2,2-dimethylpropyl)...)
Affinity DataKi:  0.590nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611937((2R,3R,11bR)-9- (cyclopropylmethoxy)-3-(2,2- dimet...)
Affinity DataKi:  0.680nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611954((2R,3R,11bR)-9-[(2,2- difluorocyclopropyl)methoxy]...)
Affinity DataKi:  0.820nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611906((2R,3R,11bR)-9-{[1- (difluoromethyl)cyclo- propyl]...)
Affinity DataKi:  0.930nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611872((2R,3R,11bR)-9-cyclopropoxy- 3-(2,2-dimethylpropyl...)
Affinity DataKi:  1nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Bos taurus)
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50017712((-)-reserpine | (3beta,16beta,17alpha,18beta,20alp...)
Affinity DataKi:  1nMAssay Description:Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghostsMore data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  1.03nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal homogenate after 60 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611856((2R,3R,11bR)-3-(2,2- dimethylpropyl)-10-methoxy- 9...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611858((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-ethoxy-10- ...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611900((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-[(2R)-2- hy...)
Affinity DataKi:  1.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611858((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-ethoxy-10- ...)
Affinity DataKi:  1.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611895((2R,3R,11bR)-3-(2,2- dimethylpropyl)-10-methoxy- 9...)
Affinity DataKi:  1.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611908(5-({[(2R,3R,11bR)-3-(2,2- dimethylpropyl)-2-hydrox...)
Affinity DataKi:  1.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611953((2R,3R,11bR)-3-(2,2- dimethylpropyl)-10-methoxy- 9...)
Affinity DataKi:  1.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611876((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-[(1- fluoro...)
Affinity DataKi:  1.60nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  1.90nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  1.90nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  1.90nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2nMAssay Description:Inhibition of VMAT2 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2nMAssay Description:Inhibition of VMAT2 in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611854((2R,3R,11bR)-9-(2,2- difluoroethoxy)-3-(2,2- dimet...)
Affinity DataKi:  2.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611950((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-[2-(4- fluo...)
Affinity DataKi:  2.20nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611842((2R,3R,11bR)-3-(2,2- dimethylpropyl)-10-methoxy- 9...)
Affinity DataKi:  2.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611889(2-(2-{[(2R,3R,11bR)-3-(2,2- dimethylpropyl)-2-hydr...)
Affinity DataKi:  2.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.45nMAssay Description:Displacement of [125I]-iodovinyl-TBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611897((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-(methoxy- d...)
Affinity DataKi:  2.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM516376(US11053242, Compound 1-1)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  2.60nMAssay Description:Examples of techniques for determining the capability of a compound to inhibit VMAT2 are provided below. The procedure is adapted from that described...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50048893((2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-2-methyl-1,...)
Affinity DataKi:  2.60nMAssay Description:Compound was tested in vitro for the inhibition of [3H]- Methoxytetrabenazine binding to rat brain vesicular monoamine transporter 2 (VMAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611855((2R,3R,11bR)-9-(2,2- difluoropropoxy)-3-(2,2- dime...)
Affinity DataKi:  2.60nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611909((2R,3R,11bR)-9-(benzyloxy)- 3-(2,2-dimethylpropyl)...)
Affinity DataKi:  3.10nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611853((2S,3R,11bR)-3-(2,2- dimethylpropyl)-10-methoxy- 9...)
Affinity DataKi:  3.40nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611910((2R,3R,11bR)-3-(2,2- dimethylpropyl)-9-[(1- fluoro...)
Affinity DataKi:  3.5nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611911((2R,3R,11bR)-3-(2,2- dimethylpropyl)-10-methoxy- 9...)
Affinity DataKi:  3.70nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Homo sapiens (Human))
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)

Curated by ChEMBL
LigandPNGBDBM611883((2R,3R,11bR)-3-(2,2- dimethylpropyl)-10-methoxy- 9...)
Affinity DataKi:  3.70nMAssay Description:The human VMAT2 Ki values for the compounds listed in Table 15A and Table 15B were determined using the following procedures. Compound dilution serie...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  3.75nMAssay Description:Displacement of [3H]-DTBZ from VMAT2 in rat striatal membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50301021((+)-dihydrotetrabenzaine | CHEMBL576222 | US110532...)
Affinity DataKi:  3.96nMAssay Description:Displacement of [3H]DHTBZ from Sprague-Dawley rat striatum VMAT2 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSynaptic vesicular amine transporter(Bos taurus)
Wichita State University

Curated by ChEMBL
LigandPNGBDBM50017701(3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...)
Affinity DataKi:  4nMAssay Description:Inhibition of dopamine uptake at VMAT in bovine chromaffin granule ghostsMore data for this Ligand-Target Pair
TargetSynaptic vesicular amine transporter(Rattus norvegicus (Rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50080818((-)-lobeline | 2-(6-(2-Hydroxy-2-phenylethyl)-1-me...)
Affinity DataKi:  4nMAssay Description:Inhibition constant against [3H]-nicotine binding to vesicular monoamine transporter-2 of rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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