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Found 419 Enz. Inhib. hit(s) with Target = 'Alpha-synuclein'
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103964(CHEMBL3593932)
Affinity DataKi:  2.10nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103961(CHEMBL3593930)
Affinity DataKi:  3.5nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103936(CHEMBL3593928)
Affinity DataKi:  3.80nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104103(CHEMBL3593911)
Affinity DataKi:  4.20nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM481149(US10906900, Reference 22a)
Affinity DataKi:  4.70nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103979(CHEMBL3593904)
Affinity DataKi:  12nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103934(CHEMBL3593926)
Affinity DataKi:  13nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM481153(US10906900, Reference 22f)
Affinity DataKi:  14.8nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104109(CHEMBL3593922)
Affinity DataKi:  15nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM481154(US10906900, Reference 22g)
Affinity DataKi:  19nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM481155(US10906900, Reference 22h)
Affinity DataKi:  20.7nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103932(CHEMBL3593924)
Affinity DataKi:  25nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50185987(2-(1-(6-((2-fluoroethyl)(methyl)amino)naphthalen-2...)
Affinity DataKi:  25.1nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM481151(US10906900, Reference 22c)
Affinity DataKi:  26nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM481150(US10906900, Reference 22b)
Affinity DataKi:  28.7nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104145(CHEMBL3593915)
Affinity DataKi:  30nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50389294(CHEMBL2063787)
Affinity DataKi:  32.1nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103927(CHEMBL3593903)
Affinity DataKi:  41nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104059(CHEMBL3593909)
Affinity DataKi:  41nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104144(CHEMBL3593916)
Affinity DataKi:  44nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104106(CHEMBL3593913)
Affinity DataKi:  45nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104116(CHEMBL3593918)
Affinity DataKi:  45nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50389304(CHEMBL2063797)
Affinity DataKi:  49nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM481152(US10906900, Reference 22e)
Affinity DataKi:  49.9nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103963(CHEMBL3593931)
Affinity DataKi:  53nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103980(CHEMBL3593905)
Affinity DataKi:  54nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104060(CHEMBL3593910)
Affinity DataKi:  55nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50389305(CHEMBL2063798)
Affinity DataKi:  57.9nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103928(CHEMBL3593902)
Affinity DataKi:  61nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104058(CHEMBL3593908)
Affinity DataKi:  64nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103937(CHEMBL3593929)
Affinity DataKi:  65nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104107(CHEMBL3593914)
Affinity DataKi:  68nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104143(CHEMBL3593917)
Affinity DataKi:  68nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104034(CHEMBL3593907)
Affinity DataKi:  73nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50389295(CHEMBL2063788)
Affinity DataKi:  75.3nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103965(CHEMBL3593933)
Affinity DataKi:  76nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50492518(Florbetapir | US10906900, AV45)
Affinity DataKi:  76.6nMAssay Description:Table 5: Fresh solutions of the test compounds (2.5 mM in DMSO) are diluted in PBS pH7.4, at concentrations between 0.5 nM and 5 μM in the prese...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103931(CHEMBL3593900)
Affinity DataKi:  80nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103935(CHEMBL3593927)
Affinity DataKi:  82nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM17747((3Z)-3-{[4-(dimethylamino)phenyl]methylidene}-2,3-...)
Affinity DataKi:  84nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM170546(US9085549, 57 | US9085549, 64)
Affinity DataKi:  89nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50104105(CHEMBL3593912)
Affinity DataKi:  92nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM170553(US9085549, 58)
Affinity DataKi:  105nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50389296(CHEMBL2063789)
Affinity DataKi:  106nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103970(CHEMBL3593896)
Affinity DataKi:  115nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50389291(CHEMBL1976750)
Affinity DataKi:  117nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50389292(CHEMBL2063785)
Affinity DataKi:  122nMAssay Description:Binding affinity to human alpha-synuclein expressed in Escherichia coli BL21 (DE3) cells after 1 hr by thioflavin T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM170546(US9085549, 57 | US9085549, 64)
Affinity DataKi:  124nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM50103966(CHEMBL3593893)
Affinity DataKi:  124nMAssay Description:Displacement of Thio-T from recombinant alpha-synuclein (unknown origin) expressed in Escherichia coli after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-synuclein(Homo sapiens (Human))
Washington University

Curated by ChEMBL
LigandPNGBDBM170556(US9085549, 66)
Affinity DataKi:  135nMpH: 7.4Assay Description:The compounds prepared in the preceding examples were found to bind with high affinity to α-synuclein aggregates/fibrils that are found in the h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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