BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 162983 [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C20H8N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-11H AGLIFTAZEUCEAB-UHFFFAOYSA-N 50020712 CHEMBL629::Amitriptylin::10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine::3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene::3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine::5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene::3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine::10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene::AMITRIPTYLINE::US20240189287, Compound Amitriptyline Muscarinic acetylcholine receptor M1 Homo sapiens 14.7 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020712&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 2160 103931468 CHEMBL629 DB00321 C06824 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162984 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 SNPPWIUOZRMYNY-UHFFFAOYSA-N 50048392 BUPROPION HYDROCHLORIDE::CHEMBL894::2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::US9944618, Compound ID No. 176 Muscarinic acetylcholine receptor M1 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048392&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 444 103978858 CHEMBL894 DB01156 C06860 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162985 [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12 |c:16| InChI=1S/C21H8N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-9H AYFAGRAOJPSHSH-UHFFFAOYSA-N 50017721 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene::4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine::4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine::1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine::1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine::CHEMBL516::4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine::CYPROHEPTADINE Muscarinic acetylcholine receptor M1 Homo sapiens 12 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017721&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 2913 103928989 CHEMBL516 DB00434 C06935 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162986 CNCCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 HCYAFALTSJYZDH-UHFFFAOYSA-N 35229 Desmethylimipramine::3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine::monodemethylimipramine::Desipramin::5-(gamma-methylaminopropyl)iminodibenzyl::norimipramine::CHEMBL72::DESIPRAMINE HYDROCHLORIDE::demethylimipramine::N-(3-methylaminopropyl)iminobibenzyl::DMI::Desipramine::US9944618, Compound ID No. 174 Muscarinic acetylcholine receptor M1 Homo sapiens 110 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35229&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search DSM 7Q19,2QJU,7Q2N,7Q2O,7Q2P,8HFI,8WGR,2QB4 2995 85753308 CHEMBL72 DB01151 C06943 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162987 N[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2 SRPXSILJHWNFMK-UHFFFAOYSA-N 50028066 CHEMBL40733::Desmethylsertraline::4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ylamine, HCl Muscarinic acetylcholine receptor M1 Homo sapiens 1650 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028066&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 114743 103937445 CHEMBL40733 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162988 CN(C)CCC=C1c2ccccc2CSc2ccccc12 |w:5.4| InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 PHTUQLWOUWZIMZ-UHFFFAOYSA-N 82548 CAS_897-15-4::NSC_3155::Dothiepin Muscarinic acetylcholine receptor M1 Homo sapiens 18 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82548&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 5282426 136350518 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162989 CN(C)CC/C=C\1/c2ccccc2COc3c1cccc3 InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 ODQWQRRAPPTVAG-UHFFFAOYSA-N 50079527 CHEMBL101740::cis-doxepin::DOXEPIN::(3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine(3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine Muscarinic acetylcholine receptor M1 Homo sapiens 38 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079527&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search D7V 3RZE 667468 103971748 CHEMBL101740 C06971 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162990 CCc1nn(CCCN2CCN(CC2)c2cccc(Cl)c2)c(=O)n1CC InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23(14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3 IZBNNCFOBMGTQX-UHFFFAOYSA-N 82438 NSC_40589::CAS_52942-31-1::Etoperidone Muscarinic acetylcholine receptor M1 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82438&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 40589 136350409 DB09194 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162991 COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1 InChI=1S/C20H25NO2/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19/h3-11,17,20H,12-15H2,1-2H3 OJSFTALXCYKKFQ-UHFFFAOYSA-N 50014247 (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine::Femoxetine::CHEMBL94739::3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine) Muscarinic acetylcholine receptor M1 Homo sapiens 92 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50014247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50014247&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 3012003 103926269 CHEMBL94739 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162992 CNCC[C@H](c1ccccc1)Oc2ccc(cc2)C(F)(F)F InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 30130 Prozac::cid_62857::Fluoxetin::CHEMBL41::CHEMBL1201082::Fluoxetine::US9120771, Fluoxetine Muscarinic acetylcholine receptor M1 Homo sapiens 1030 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30130&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search RFX 4MM8,3GWV 3386 85147891 CHEMBL1201082CHEMBL41 DB00472 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162993 CN(C)CCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 BCGWQEUPMDMJNV-UHFFFAOYSA-N 50010859 CHEMBL11::Imipramin::IMIPRAMINE HYDROCHLORIDE::IMIPRAMINE PAMOATE Muscarinic acetylcholine receptor M1 Homo sapiens 42 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010859&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search IXX 2Q72,7LWD,6G9B 3696 103923605 CHEMBL11 DB00458 C07049 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162994 CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1 InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3 SAPNXPWPAUFAJU-UHFFFAOYSA-N 82437 CAS_23047-25-8::NSC_3947::US8629135, SW-06::Lofepramine Muscarinic acetylcholine receptor M1 Homo sapiens 67 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82437&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 3947 136350408 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162995 C(C1C[NH+]2CCC1CC2)N1c2ccccc2Sc2ccccc12 |THB:0:1:5.4:7.8,(14.51,-5.48,;15.79,-4.74,;17.21,-5.13,;17.6,-2.22,;20.16,-.74,;19.42,.54,;16.17,-1.84,;14.72,-.36,;16,.37,;14.51,-6.96,;15.79,-7.7,;17.11,-6.91,;18.45,-7.67,;18.45,-9.21,;17.11,-9.97,;15.79,-9.18,;14.51,-9.92,;13.22,-9.18,;11.9,-9.97,;10.56,-9.21,;10.56,-7.67,;11.9,-6.91,;13.22,-7.7,)| 28347 Mequitazine::3-(10H-phenothiazin-10-ylmethyl)-1-azabicyclo[2.2.2]octan-1-ium::ZINC01567421, 6 Muscarinic acetylcholine receptor M1 Homo sapiens 5.6 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28347&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 25263218 58097536 C12755 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162996 c1ccc(cc1)[C@H](CCN)Oc2ccc(cc2)C(F)(F)F InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2 WIQRCHMSJFFONW-UHFFFAOYSA-N 50254790 NORFLUOXETINE::CHEMBL465123::(S)-Norfluoxetine Muscarinic acetylcholine receptor M1 Homo sapiens 1200 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254790&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 405 4XDK 3058751 104106938 CHEMBL465123 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162997 [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C19H8N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10H UDDYRZAAZAXGQW-UHFFFAOYSA-N 112777 NORTRIPTYLINE::US8629135, SW-02 Muscarinic acetylcholine receptor M1 Homo sapiens 40 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112777&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 4543 194690518 DB00540 C07274 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162998 CN(C)CCOC(c1ccccc1)c1ccccc1C InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 QVYRGXJJSLMXQH-UHFFFAOYSA-N 50062614 Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine::Orphengesic::Norflex::CHEMBL900::Disipal::Invagesic::N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine::Norgesic::ORPHENADRINE Muscarinic acetylcholine receptor M1 Homo sapiens 48 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062614&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 4601 103958137 CHEMBL900 DB01173 C07935 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 162999 c1cc(ccc1[C@@H]2CCNC[C@H]2COc3ccc4c(c3)OCO4)F InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2 AHOUBRCZNHFOSL-UHFFFAOYSA-N 22416 PAROXETINE::CHEMBL490::(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::[3H]Paroxetine::US09969700, Paroxetine::US9944618, Compound ID No. 182 Muscarinic acetylcholine receptor M1 Homo sapiens 300 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22416&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 8PR 6F6I,7OIH,6DZW,6AWN,4JLT,3V5W,4MM4,6VRH,5I6X,4L9I 43815 49846231 CHEMBL490 DB00715 C07415 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 163000 c1ccc(cc1)C(c2ccccc2)(C(=O)O)O InChI=1S/C14H12O3/c15-13(16)14(17,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,17H,(H,15,16) UKXSKSHDVLQNKG-UHFFFAOYSA-N 81768 BENZYLIC ACID::NSC_5311391::CAS_6581-06-2::Quinuclidinyl benzilate Muscarinic acetylcholine receptor M1 Homo sapiens 0.044 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81768&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 0UT 4HNC 6463 131342342 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 163001 CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3 VGKDLMBJGBXTGI-UHFFFAOYSA-N 82217 [4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine::SERTRALINE::CHEMBL284994::CP-52003 Muscarinic acetylcholine receptor M1 Homo sapiens 1300 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82217&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 9882979 136350189 CHEMBL284994 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 163002 Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 PHLBKPHSAVXXEF-UHFFFAOYSA-N 50073444 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one::CHEMBL621::TRAZODONE Muscarinic acetylcholine receptor M1 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073444&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 5533 103966838 CHEMBL621 DB00656 C07156 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 163003 COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1 InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 PNVNVHUZROJLTJ-UHFFFAOYSA-N 82071 NSC_62923::WY-45030::VENLAFAXINE::CAS_93413-69-5::Venlafaxine hydrochloride::CAS_99300-78-4::WY-45655 Muscarinic acetylcholine receptor M1 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10062&target=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82071&enzyme=Muscarinic+acetylcholine+receptor+M1&column=ki&startPg=0&Increment=50&submit=Search 5656 131342645 DB00285 C07187 1 MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC Muscarinic acetylcholine receptor M1 ACM1_HUMAN P11229 Q96RH1 163004 CN(C)Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12 |t:9| InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3 GJSLOMWRLALDCT-UHFFFAOYSA-N 82439 NSC_37632::CAS_37115-32-5::Adinazolam Muscarinic acetylcholine receptor M2 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82439&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 37632 136350410 DB00546 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163005 [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C20H8N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-11H AGLIFTAZEUCEAB-UHFFFAOYSA-N 50020712 CHEMBL629::Amitriptylin::10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine::3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene::3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine::5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene::3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine::10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene::AMITRIPTYLINE::US20240189287, Compound Amitriptyline Muscarinic acetylcholine receptor M2 Homo sapiens 11.8 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020712&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 2160 103931468 CHEMBL629 DB00321 C06824 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163006 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 SNPPWIUOZRMYNY-UHFFFAOYSA-N 50048392 BUPROPION HYDROCHLORIDE::CHEMBL894::2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::US9944618, Compound ID No. 176 Muscarinic acetylcholine receptor M2 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048392&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 444 103978858 CHEMBL894 DB01156 C06860 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163007 [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12 |c:16| InChI=1S/C21H8N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-9H AYFAGRAOJPSHSH-UHFFFAOYSA-N 50017721 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene::4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine::4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine::1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine::1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine::CHEMBL516::4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine::CYPROHEPTADINE Muscarinic acetylcholine receptor M2 Homo sapiens 7 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017721&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 2913 103928989 CHEMBL516 DB00434 C06935 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163008 CNCCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 HCYAFALTSJYZDH-UHFFFAOYSA-N 35229 Desmethylimipramine::3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine::monodemethylimipramine::Desipramin::5-(gamma-methylaminopropyl)iminodibenzyl::norimipramine::CHEMBL72::DESIPRAMINE HYDROCHLORIDE::demethylimipramine::N-(3-methylaminopropyl)iminobibenzyl::DMI::Desipramine::US9944618, Compound ID No. 174 Muscarinic acetylcholine receptor M2 Homo sapiens 540 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35229&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search DSM 7Q19,2QJU,7Q2N,7Q2O,7Q2P,8HFI,8WGR,2QB4 2995 85753308 CHEMBL72 DB01151 C06943 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163009 N[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2 SRPXSILJHWNFMK-UHFFFAOYSA-N 50028066 CHEMBL40733::Desmethylsertraline::4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ylamine, HCl Muscarinic acetylcholine receptor M2 Homo sapiens 3300 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028066&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 114743 103937445 CHEMBL40733 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163010 CN(C)CCC=C1c2ccccc2CSc2ccccc12 |w:5.4| InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 PHTUQLWOUWZIMZ-UHFFFAOYSA-N 82548 CAS_897-15-4::NSC_3155::Dothiepin Muscarinic acetylcholine receptor M2 Homo sapiens 109 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82548&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 5282426 136350518 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163011 CN(C)CC/C=C\1/c2ccccc2COc3c1cccc3 InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 ODQWQRRAPPTVAG-UHFFFAOYSA-N 50079527 CHEMBL101740::cis-doxepin::DOXEPIN::(3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine(3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine Muscarinic acetylcholine receptor M2 Homo sapiens 160 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079527&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search D7V 3RZE 667468 103971748 CHEMBL101740 C06971 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163012 CCc1nn(CCCN2CCN(CC2)c2cccc(Cl)c2)c(=O)n1CC InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23(14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3 IZBNNCFOBMGTQX-UHFFFAOYSA-N 82438 NSC_40589::CAS_52942-31-1::Etoperidone Muscarinic acetylcholine receptor M2 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82438&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 40589 136350409 DB09194 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163013 COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1 InChI=1S/C20H25NO2/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19/h3-11,17,20H,12-15H2,1-2H3 OJSFTALXCYKKFQ-UHFFFAOYSA-N 50014247 (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine::Femoxetine::CHEMBL94739::3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine) Muscarinic acetylcholine receptor M2 Homo sapiens 150 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50014247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50014247&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 3012003 103926269 CHEMBL94739 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163014 CNCC[C@H](c1ccccc1)Oc2ccc(cc2)C(F)(F)F InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 30130 Prozac::cid_62857::Fluoxetin::CHEMBL41::CHEMBL1201082::Fluoxetine::US9120771, Fluoxetine Muscarinic acetylcholine receptor M2 Homo sapiens 2700 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30130&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search RFX 4MM8,3GWV 3386 85147891 CHEMBL1201082CHEMBL41 DB00472 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163015 CN(C)CCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 BCGWQEUPMDMJNV-UHFFFAOYSA-N 50010859 CHEMBL11::Imipramin::IMIPRAMINE HYDROCHLORIDE::IMIPRAMINE PAMOATE Muscarinic acetylcholine receptor M2 Homo sapiens 88 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010859&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search IXX 2Q72,7LWD,6G9B 3696 103923605 CHEMBL11 DB00458 C07049 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163016 CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1 InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3 SAPNXPWPAUFAJU-UHFFFAOYSA-N 82437 CAS_23047-25-8::NSC_3947::US8629135, SW-06::Lofepramine Muscarinic acetylcholine receptor M2 Homo sapiens 330 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82437&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 3947 136350408 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163017 C(C1C[NH+]2CCC1CC2)N1c2ccccc2Sc2ccccc12 |THB:0:1:5.4:7.8,(14.51,-5.48,;15.79,-4.74,;17.21,-5.13,;17.6,-2.22,;20.16,-.74,;19.42,.54,;16.17,-1.84,;14.72,-.36,;16,.37,;14.51,-6.96,;15.79,-7.7,;17.11,-6.91,;18.45,-7.67,;18.45,-9.21,;17.11,-9.97,;15.79,-9.18,;14.51,-9.92,;13.22,-9.18,;11.9,-9.97,;10.56,-9.21,;10.56,-7.67,;11.9,-6.91,;13.22,-7.7,)| 28347 Mequitazine::3-(10H-phenothiazin-10-ylmethyl)-1-azabicyclo[2.2.2]octan-1-ium::ZINC01567421, 6 Muscarinic acetylcholine receptor M2 Homo sapiens 14 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28347&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 25263218 58097536 C12755 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163018 c1ccc(cc1)[C@H](CCN)Oc2ccc(cc2)C(F)(F)F InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2 WIQRCHMSJFFONW-UHFFFAOYSA-N 50254790 NORFLUOXETINE::CHEMBL465123::(S)-Norfluoxetine Muscarinic acetylcholine receptor M2 Homo sapiens 4600 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254790&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 405 4XDK 3058751 104106938 CHEMBL465123 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163019 [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C19H8N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10H UDDYRZAAZAXGQW-UHFFFAOYSA-N 112777 NORTRIPTYLINE::US8629135, SW-02 Muscarinic acetylcholine receptor M2 Homo sapiens 110 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112777&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 4543 194690518 DB00540 C07274 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163020 CN(C)CCOC(c1ccccc1)c1ccccc1C InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 QVYRGXJJSLMXQH-UHFFFAOYSA-N 50062614 Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine::Orphengesic::Norflex::CHEMBL900::Disipal::Invagesic::N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine::Norgesic::ORPHENADRINE Muscarinic acetylcholine receptor M2 Homo sapiens 213 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062614&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 4601 103958137 CHEMBL900 DB01173 C07935 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163021 c1cc(ccc1[C@@H]2CCNC[C@H]2COc3ccc4c(c3)OCO4)F InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2 AHOUBRCZNHFOSL-UHFFFAOYSA-N 22416 PAROXETINE::CHEMBL490::(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::[3H]Paroxetine::US09969700, Paroxetine::US9944618, Compound ID No. 182 Muscarinic acetylcholine receptor M2 Homo sapiens 340 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22416&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 8PR 6F6I,7OIH,6DZW,6AWN,4JLT,3V5W,4MM4,6VRH,5I6X,4L9I 43815 49846231 CHEMBL490 DB00715 C07415 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163022 c1ccc(cc1)C(c2ccccc2)(C(=O)O)O InChI=1S/C14H12O3/c15-13(16)14(17,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,17H,(H,15,16) UKXSKSHDVLQNKG-UHFFFAOYSA-N 81768 BENZYLIC ACID::NSC_5311391::CAS_6581-06-2::Quinuclidinyl benzilate Muscarinic acetylcholine receptor M2 Homo sapiens 0.03 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81768&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 0UT 4HNC 6463 131342342 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163023 CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3 VGKDLMBJGBXTGI-UHFFFAOYSA-N 82217 [4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine::SERTRALINE::CHEMBL284994::CP-52003 Muscarinic acetylcholine receptor M2 Homo sapiens 2100 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82217&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 9882979 136350189 CHEMBL284994 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163024 Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 PHLBKPHSAVXXEF-UHFFFAOYSA-N 50073444 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one::CHEMBL621::TRAZODONE Muscarinic acetylcholine receptor M2 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073444&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 5533 103966838 CHEMBL621 DB00656 C07156 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163025 COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1 InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 PNVNVHUZROJLTJ-UHFFFAOYSA-N 82071 NSC_62923::WY-45030::VENLAFAXINE::CAS_93413-69-5::Venlafaxine hydrochloride::CAS_99300-78-4::WY-45655 Muscarinic acetylcholine receptor M2 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9678&target=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82071&enzyme=Muscarinic+acetylcholine+receptor+M2&column=ki&startPg=0&Increment=50&submit=Search 5656 131342645 DB00285 C07187 1 MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR 6U1N,5ZKC,5ZKB,5ZK3,5YC8 Muscarinic acetylcholine receptor M2 ACM2_HUMAN P08172 Q4VBK6 Q9P1X9 163026 CN(C)Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12 |t:9| InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3 GJSLOMWRLALDCT-UHFFFAOYSA-N 82439 NSC_37632::CAS_37115-32-5::Adinazolam Muscarinic acetylcholine receptor M3 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82439&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 37632 136350410 DB00546 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163027 [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C20H8N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-11H AGLIFTAZEUCEAB-UHFFFAOYSA-N 50020712 CHEMBL629::Amitriptylin::10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine::3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene::3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine::5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene::3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine::10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene::AMITRIPTYLINE::US20240189287, Compound Amitriptyline Muscarinic acetylcholine receptor M3 Homo sapiens 12.8 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020712&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 2160 103931468 CHEMBL629 DB00321 C06824 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163028 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 SNPPWIUOZRMYNY-UHFFFAOYSA-N 50048392 BUPROPION HYDROCHLORIDE::CHEMBL894::2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::US9944618, Compound ID No. 176 Muscarinic acetylcholine receptor M3 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048392&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 444 103978858 CHEMBL894 DB01156 C06860 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163029 [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12 |c:16| InChI=1S/C21H8N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-9H AYFAGRAOJPSHSH-UHFFFAOYSA-N 50017721 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene::4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine::4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine::1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine::1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine::CHEMBL516::4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine::CYPROHEPTADINE Muscarinic acetylcholine receptor M3 Homo sapiens 12 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017721&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 2913 103928989 CHEMBL516 DB00434 C06935 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163030 CNCCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 HCYAFALTSJYZDH-UHFFFAOYSA-N 35229 Desmethylimipramine::3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine::monodemethylimipramine::Desipramin::5-(gamma-methylaminopropyl)iminodibenzyl::norimipramine::CHEMBL72::DESIPRAMINE HYDROCHLORIDE::demethylimipramine::N-(3-methylaminopropyl)iminobibenzyl::DMI::Desipramine::US9944618, Compound ID No. 174 Muscarinic acetylcholine receptor M3 Homo sapiens 210 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35229&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search DSM 7Q19,2QJU,7Q2N,7Q2O,7Q2P,8HFI,8WGR,2QB4 2995 85753308 CHEMBL72 DB01151 C06943 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163031 N[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2 SRPXSILJHWNFMK-UHFFFAOYSA-N 50028066 CHEMBL40733::Desmethylsertraline::4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ylamine, HCl Muscarinic acetylcholine receptor M3 Homo sapiens 3500 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028066&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 114743 103937445 CHEMBL40733 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163032 CN(C)CCC=C1c2ccccc2CSc2ccccc12 |w:5.4| InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 PHTUQLWOUWZIMZ-UHFFFAOYSA-N 82548 CAS_897-15-4::NSC_3155::Dothiepin Muscarinic acetylcholine receptor M3 Homo sapiens 38 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82548&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 5282426 136350518 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163033 CN(C)CC/C=C\1/c2ccccc2COc3c1cccc3 InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 ODQWQRRAPPTVAG-UHFFFAOYSA-N 50079527 CHEMBL101740::cis-doxepin::DOXEPIN::(3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine(3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine Muscarinic acetylcholine receptor M3 Homo sapiens 52 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079527&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search D7V 3RZE 667468 103971748 CHEMBL101740 C06971 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163034 CCc1nn(CCCN2CCN(CC2)c2cccc(Cl)c2)c(=O)n1CC InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23(14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3 IZBNNCFOBMGTQX-UHFFFAOYSA-N 82438 NSC_40589::CAS_52942-31-1::Etoperidone Muscarinic acetylcholine receptor M3 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82438&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 40589 136350409 DB09194 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163035 COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1 InChI=1S/C20H25NO2/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19/h3-11,17,20H,12-15H2,1-2H3 OJSFTALXCYKKFQ-UHFFFAOYSA-N 50014247 (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine::Femoxetine::CHEMBL94739::3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine) Muscarinic acetylcholine receptor M3 Homo sapiens 220 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50014247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50014247&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 3012003 103926269 CHEMBL94739 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163036 CNCC[C@H](c1ccccc1)Oc2ccc(cc2)C(F)(F)F InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 30130 Prozac::cid_62857::Fluoxetin::CHEMBL41::CHEMBL1201082::Fluoxetine::US9120771, Fluoxetine Muscarinic acetylcholine receptor M3 Homo sapiens 1000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30130&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search RFX 4MM8,3GWV 3386 85147891 CHEMBL1201082CHEMBL41 DB00472 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163037 CN(C)CCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 BCGWQEUPMDMJNV-UHFFFAOYSA-N 50010859 CHEMBL11::Imipramin::IMIPRAMINE HYDROCHLORIDE::IMIPRAMINE PAMOATE Muscarinic acetylcholine receptor M3 Homo sapiens 60 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010859&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search IXX 2Q72,7LWD,6G9B 3696 103923605 CHEMBL11 DB00458 C07049 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163038 CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1 InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3 SAPNXPWPAUFAJU-UHFFFAOYSA-N 82437 CAS_23047-25-8::NSC_3947::US8629135, SW-06::Lofepramine Muscarinic acetylcholine receptor M3 Homo sapiens 130 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82437&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 3947 136350408 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163039 C(C1C[NH+]2CCC1CC2)N1c2ccccc2Sc2ccccc12 |THB:0:1:5.4:7.8,(14.51,-5.48,;15.79,-4.74,;17.21,-5.13,;17.6,-2.22,;20.16,-.74,;19.42,.54,;16.17,-1.84,;14.72,-.36,;16,.37,;14.51,-6.96,;15.79,-7.7,;17.11,-6.91,;18.45,-7.67,;18.45,-9.21,;17.11,-9.97,;15.79,-9.18,;14.51,-9.92,;13.22,-9.18,;11.9,-9.97,;10.56,-9.21,;10.56,-7.67,;11.9,-6.91,;13.22,-7.7,)| 28347 Mequitazine::3-(10H-phenothiazin-10-ylmethyl)-1-azabicyclo[2.2.2]octan-1-ium::ZINC01567421, 6 Muscarinic acetylcholine receptor M3 Homo sapiens 5.3 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28347&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 25263218 58097536 C12755 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163040 c1ccc(cc1)[C@H](CCN)Oc2ccc(cc2)C(F)(F)F InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2 WIQRCHMSJFFONW-UHFFFAOYSA-N 50254790 NORFLUOXETINE::CHEMBL465123::(S)-Norfluoxetine Muscarinic acetylcholine receptor M3 Homo sapiens 760 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254790&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 405 4XDK 3058751 104106938 CHEMBL465123 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163041 [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C19H8N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10H UDDYRZAAZAXGQW-UHFFFAOYSA-N 112777 NORTRIPTYLINE::US8629135, SW-02 Muscarinic acetylcholine receptor M3 Homo sapiens 50 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112777&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 4543 194690518 DB00540 C07274 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163042 CN(C)CCOC(c1ccccc1)c1ccccc1C InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 QVYRGXJJSLMXQH-UHFFFAOYSA-N 50062614 Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine::Orphengesic::Norflex::CHEMBL900::Disipal::Invagesic::N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine::Norgesic::ORPHENADRINE Muscarinic acetylcholine receptor M3 Homo sapiens 120 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062614&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 4601 103958137 CHEMBL900 DB01173 C07935 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163043 c1cc(ccc1[C@@H]2CCNC[C@H]2COc3ccc4c(c3)OCO4)F InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2 AHOUBRCZNHFOSL-UHFFFAOYSA-N 22416 PAROXETINE::CHEMBL490::(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::[3H]Paroxetine::US09969700, Paroxetine::US9944618, Compound ID No. 182 Muscarinic acetylcholine receptor M3 Homo sapiens 80 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22416&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 8PR 6F6I,7OIH,6DZW,6AWN,4JLT,3V5W,4MM4,6VRH,5I6X,4L9I 43815 49846231 CHEMBL490 DB00715 C07415 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163044 c1ccc(cc1)C(c2ccccc2)(C(=O)O)O InChI=1S/C14H12O3/c15-13(16)14(17,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,17H,(H,15,16) UKXSKSHDVLQNKG-UHFFFAOYSA-N 81768 BENZYLIC ACID::NSC_5311391::CAS_6581-06-2::Quinuclidinyl benzilate Muscarinic acetylcholine receptor M3 Homo sapiens 0.08 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81768&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 0UT 4HNC 6463 131342342 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163045 CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3 VGKDLMBJGBXTGI-UHFFFAOYSA-N 82217 [4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine::SERTRALINE::CHEMBL284994::CP-52003 Muscarinic acetylcholine receptor M3 Homo sapiens 1300 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82217&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 9882979 136350189 CHEMBL284994 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163046 Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 PHLBKPHSAVXXEF-UHFFFAOYSA-N 50073444 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one::CHEMBL621::TRAZODONE Muscarinic acetylcholine receptor M3 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073444&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 5533 103966838 CHEMBL621 DB00656 C07156 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163047 COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1 InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 PNVNVHUZROJLTJ-UHFFFAOYSA-N 82071 NSC_62923::WY-45030::VENLAFAXINE::CAS_93413-69-5::Venlafaxine hydrochloride::CAS_99300-78-4::WY-45655 Muscarinic acetylcholine receptor M3 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5682&target=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82071&enzyme=Muscarinic+acetylcholine+receptor+M3&column=ki&startPg=0&Increment=50&submit=Search 5656 131342645 DB00285 C07187 1 MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMKRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL 8E9W,8EA0,8E9Z,8E9Y Muscarinic acetylcholine receptor M3 ACM3_HUMAN P20309 Q0VAJ8 Q4QRI3 Q5VXY2 Q9HB60 163048 CN(C)Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12 |t:9| InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3 GJSLOMWRLALDCT-UHFFFAOYSA-N 82439 NSC_37632::CAS_37115-32-5::Adinazolam Muscarinic acetylcholine receptor M4 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82439&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 37632 136350410 DB00546 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163049 [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C20H8N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-11H AGLIFTAZEUCEAB-UHFFFAOYSA-N 50020712 CHEMBL629::Amitriptylin::10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine::3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene::3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine::5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene::3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine::10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene::AMITRIPTYLINE::US20240189287, Compound Amitriptyline Muscarinic acetylcholine receptor M4 Homo sapiens 7.2 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020712&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 2160 103931468 CHEMBL629 DB00321 C06824 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163050 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 SNPPWIUOZRMYNY-UHFFFAOYSA-N 50048392 BUPROPION HYDROCHLORIDE::CHEMBL894::2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::US9944618, Compound ID No. 176 Muscarinic acetylcholine receptor M4 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048392&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 444 103978858 CHEMBL894 DB01156 C06860 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163051 [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12 |c:16| InChI=1S/C21H8N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-9H AYFAGRAOJPSHSH-UHFFFAOYSA-N 50017721 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene::4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine::4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine::1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine::1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine::CHEMBL516::4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine::CYPROHEPTADINE Muscarinic acetylcholine receptor M4 Homo sapiens 8 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017721&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 2913 103928989 CHEMBL516 DB00434 C06935 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163052 CNCCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 HCYAFALTSJYZDH-UHFFFAOYSA-N 35229 Desmethylimipramine::3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine::monodemethylimipramine::Desipramin::5-(gamma-methylaminopropyl)iminodibenzyl::norimipramine::CHEMBL72::DESIPRAMINE HYDROCHLORIDE::demethylimipramine::N-(3-methylaminopropyl)iminobibenzyl::DMI::Desipramine::US9944618, Compound ID No. 174 Muscarinic acetylcholine receptor M4 Homo sapiens 160 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35229&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search DSM 7Q19,2QJU,7Q2N,7Q2O,7Q2P,8HFI,8WGR,2QB4 2995 85753308 CHEMBL72 DB01151 C06943 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163053 N[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2 SRPXSILJHWNFMK-UHFFFAOYSA-N 50028066 CHEMBL40733::Desmethylsertraline::4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ylamine, HCl Muscarinic acetylcholine receptor M4 Homo sapiens 3100 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028066&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 114743 103937445 CHEMBL40733 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163054 CN(C)CCC=C1c2ccccc2CSc2ccccc12 |w:5.4| InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 PHTUQLWOUWZIMZ-UHFFFAOYSA-N 82548 CAS_897-15-4::NSC_3155::Dothiepin Muscarinic acetylcholine receptor M4 Homo sapiens 61 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82548&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 5282426 136350518 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163055 CN(C)CC/C=C\1/c2ccccc2COc3c1cccc3 InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 ODQWQRRAPPTVAG-UHFFFAOYSA-N 50079527 CHEMBL101740::cis-doxepin::DOXEPIN::(3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine(3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine Muscarinic acetylcholine receptor M4 Homo sapiens 82 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079527&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search D7V 3RZE 667468 103971748 CHEMBL101740 C06971 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163056 CCc1nn(CCCN2CCN(CC2)c2cccc(Cl)c2)c(=O)n1CC InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23(14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3 IZBNNCFOBMGTQX-UHFFFAOYSA-N 82438 NSC_40589::CAS_52942-31-1::Etoperidone Muscarinic acetylcholine receptor M4 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82438&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 40589 136350409 DB09194 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163057 COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1 InChI=1S/C20H25NO2/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19/h3-11,17,20H,12-15H2,1-2H3 OJSFTALXCYKKFQ-UHFFFAOYSA-N 50014247 (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine::Femoxetine::CHEMBL94739::3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine) Muscarinic acetylcholine receptor M4 Homo sapiens 470 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50014247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50014247&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 3012003 103926269 CHEMBL94739 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163058 CNCC[C@H](c1ccccc1)Oc2ccc(cc2)C(F)(F)F InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 30130 Prozac::cid_62857::Fluoxetin::CHEMBL41::CHEMBL1201082::Fluoxetine::US9120771, Fluoxetine Muscarinic acetylcholine receptor M4 Homo sapiens 2900 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30130&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search RFX 4MM8,3GWV 3386 85147891 CHEMBL1201082CHEMBL41 DB00472 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163059 CN(C)CCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 BCGWQEUPMDMJNV-UHFFFAOYSA-N 50010859 CHEMBL11::Imipramin::IMIPRAMINE HYDROCHLORIDE::IMIPRAMINE PAMOATE Muscarinic acetylcholine receptor M4 Homo sapiens 112 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010859&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search IXX 2Q72,7LWD,6G9B 3696 103923605 CHEMBL11 DB00458 C07049 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163060 CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1 InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3 SAPNXPWPAUFAJU-UHFFFAOYSA-N 82437 CAS_23047-25-8::NSC_3947::US8629135, SW-06::Lofepramine Muscarinic acetylcholine receptor M4 Homo sapiens 340 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82437&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 3947 136350408 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163061 C(C1C[NH+]2CCC1CC2)N1c2ccccc2Sc2ccccc12 |THB:0:1:5.4:7.8,(14.51,-5.48,;15.79,-4.74,;17.21,-5.13,;17.6,-2.22,;20.16,-.74,;19.42,.54,;16.17,-1.84,;14.72,-.36,;16,.37,;14.51,-6.96,;15.79,-7.7,;17.11,-6.91,;18.45,-7.67,;18.45,-9.21,;17.11,-9.97,;15.79,-9.18,;14.51,-9.92,;13.22,-9.18,;11.9,-9.97,;10.56,-9.21,;10.56,-7.67,;11.9,-6.91,;13.22,-7.7,)| 28347 Mequitazine::3-(10H-phenothiazin-10-ylmethyl)-1-azabicyclo[2.2.2]octan-1-ium::ZINC01567421, 6 Muscarinic acetylcholine receptor M4 Homo sapiens 11.1 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28347&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 25263218 58097536 C12755 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163062 c1ccc(cc1)[C@H](CCN)Oc2ccc(cc2)C(F)(F)F InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2 WIQRCHMSJFFONW-UHFFFAOYSA-N 50254790 NORFLUOXETINE::CHEMBL465123::(S)-Norfluoxetine Muscarinic acetylcholine receptor M4 Homo sapiens 2600 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254790&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 405 4XDK 3058751 104106938 CHEMBL465123 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163063 [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C19H8N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10H UDDYRZAAZAXGQW-UHFFFAOYSA-N 112777 NORTRIPTYLINE::US8629135, SW-02 Muscarinic acetylcholine receptor M4 Homo sapiens 84 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112777&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 4543 194690518 DB00540 C07274 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163064 CN(C)CCOC(c1ccccc1)c1ccccc1C InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 QVYRGXJJSLMXQH-UHFFFAOYSA-N 50062614 Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine::Orphengesic::Norflex::CHEMBL900::Disipal::Invagesic::N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine::Norgesic::ORPHENADRINE Muscarinic acetylcholine receptor M4 Homo sapiens 170 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062614&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 4601 103958137 CHEMBL900 DB01173 C07935 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163065 c1cc(ccc1[C@@H]2CCNC[C@H]2COc3ccc4c(c3)OCO4)F InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2 AHOUBRCZNHFOSL-UHFFFAOYSA-N 22416 PAROXETINE::CHEMBL490::(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::[3H]Paroxetine::US09969700, Paroxetine::US9944618, Compound ID No. 182 Muscarinic acetylcholine receptor M4 Homo sapiens 320 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22416&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 8PR 6F6I,7OIH,6DZW,6AWN,4JLT,3V5W,4MM4,6VRH,5I6X,4L9I 43815 49846231 CHEMBL490 DB00715 C07415 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163066 c1ccc(cc1)C(c2ccccc2)(C(=O)O)O InChI=1S/C14H12O3/c15-13(16)14(17,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,17H,(H,15,16) UKXSKSHDVLQNKG-UHFFFAOYSA-N 81768 BENZYLIC ACID::NSC_5311391::CAS_6581-06-2::Quinuclidinyl benzilate Muscarinic acetylcholine receptor M4 Homo sapiens 0.037 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81768&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 0UT 4HNC 6463 131342342 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163067 CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3 VGKDLMBJGBXTGI-UHFFFAOYSA-N 82217 [4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine::SERTRALINE::CHEMBL284994::CP-52003 Muscarinic acetylcholine receptor M4 Homo sapiens 1400 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82217&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 9882979 136350189 CHEMBL284994 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163068 Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 PHLBKPHSAVXXEF-UHFFFAOYSA-N 50073444 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one::CHEMBL621::TRAZODONE Muscarinic acetylcholine receptor M4 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073444&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 5533 103966838 CHEMBL621 DB00656 C07156 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163069 COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1 InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 PNVNVHUZROJLTJ-UHFFFAOYSA-N 82071 NSC_62923::WY-45030::VENLAFAXINE::CAS_93413-69-5::Venlafaxine hydrochloride::CAS_99300-78-4::WY-45655 Muscarinic acetylcholine receptor M4 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=49000377&target=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82071&enzyme=Muscarinic+acetylcholine+receptor+M4&column=ki&startPg=0&Increment=50&submit=Search 5656 131342645 DB00285 C07187 1 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR 8FX5,7TRS,7TRQ,7TRP,7TRK,9IQS Muscarinic acetylcholine receptor M4 ACM4_HUMAN P08173 B2RPP4 Q0VD60 Q4VBK7 163070 CN(C)Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12 |t:9| InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3 GJSLOMWRLALDCT-UHFFFAOYSA-N 82439 NSC_37632::CAS_37115-32-5::Adinazolam Muscarinic acetylcholine receptor M5 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82439&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 37632 136350410 DB00546 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163071 [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C20H8N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-11H AGLIFTAZEUCEAB-UHFFFAOYSA-N 50020712 CHEMBL629::Amitriptylin::10,11-dihydro-N,N-dimethyl-5H-dibenzo(a,d)heptalene-Delta(5),gamma-propylamine::3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene::3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine::5-(gamma-dimethylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptadiene::5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptatriene::3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine::10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,d)cycloheptene::AMITRIPTYLINE::US20240189287, Compound Amitriptyline Muscarinic acetylcholine receptor M5 Homo sapiens 15.7 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50020712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50020712&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 2160 103931468 CHEMBL629 DB00321 C06824 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163072 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 InChI=1S/C13H18ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,15H,1-4H3 SNPPWIUOZRMYNY-UHFFFAOYSA-N 50048392 BUPROPION HYDROCHLORIDE::CHEMBL894::2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one::BUPROPION::US9944618, Compound ID No. 176 Muscarinic acetylcholine receptor M5 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50048392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50048392&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 444 103978858 CHEMBL894 DB01156 C06860 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163073 [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]=[#6]-c2ccccc-12 |c:16| InChI=1S/C21H8N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-9H AYFAGRAOJPSHSH-UHFFFAOYSA-N 50017721 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene::4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine::4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine::1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine::1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine::CHEMBL516::4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine::CYPROHEPTADINE Muscarinic acetylcholine receptor M5 Homo sapiens 11.8 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50017721&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 2913 103928989 CHEMBL516 DB00434 C06935 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163074 CNCCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 HCYAFALTSJYZDH-UHFFFAOYSA-N 35229 Desmethylimipramine::3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methylpropan-1-amine::monodemethylimipramine::Desipramin::5-(gamma-methylaminopropyl)iminodibenzyl::norimipramine::CHEMBL72::DESIPRAMINE HYDROCHLORIDE::demethylimipramine::N-(3-methylaminopropyl)iminobibenzyl::DMI::Desipramine::US9944618, Compound ID No. 174 Muscarinic acetylcholine receptor M5 Homo sapiens 143 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=35229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=35229&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search DSM 7Q19,2QJU,7Q2N,7Q2O,7Q2P,8HFI,8WGR,2QB4 2995 85753308 CHEMBL72 DB01151 C06943 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163075 N[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2 SRPXSILJHWNFMK-UHFFFAOYSA-N 50028066 CHEMBL40733::Desmethylsertraline::4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-ylamine, HCl Muscarinic acetylcholine receptor M5 Homo sapiens 3800 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50028066 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50028066&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 114743 103937445 CHEMBL40733 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163076 CN(C)CCC=C1c2ccccc2CSc2ccccc12 |w:5.4| InChI=1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 PHTUQLWOUWZIMZ-UHFFFAOYSA-N 82548 CAS_897-15-4::NSC_3155::Dothiepin Muscarinic acetylcholine receptor M5 Homo sapiens 92 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82548&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 5282426 136350518 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163077 CN(C)CC/C=C\1/c2ccccc2COc3c1cccc3 InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3 ODQWQRRAPPTVAG-UHFFFAOYSA-N 50079527 CHEMBL101740::cis-doxepin::DOXEPIN::(3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine(3Z)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimethylpropan-1-amine Muscarinic acetylcholine receptor M5 Homo sapiens 75 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50079527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50079527&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search D7V 3RZE 667468 103971748 CHEMBL101740 C06971 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163078 CCc1nn(CCCN2CCN(CC2)c2cccc(Cl)c2)c(=O)n1CC InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23(14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3 IZBNNCFOBMGTQX-UHFFFAOYSA-N 82438 NSC_40589::CAS_52942-31-1::Etoperidone Muscarinic acetylcholine receptor M5 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82438&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 40589 136350409 DB09194 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163079 COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1 InChI=1S/C20H25NO2/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19/h3-11,17,20H,12-15H2,1-2H3 OJSFTALXCYKKFQ-UHFFFAOYSA-N 50014247 (3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine::Femoxetine::CHEMBL94739::3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine) Muscarinic acetylcholine receptor M5 Homo sapiens 400 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50014247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50014247&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 3012003 103926269 CHEMBL94739 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163080 CNCC[C@H](c1ccccc1)Oc2ccc(cc2)C(F)(F)F InChI=1S/C17H18F3NO/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20/h2-10,16,21H,11-12H2,1H3 RTHCYVBBDHJXIQ-UHFFFAOYSA-N 30130 Prozac::cid_62857::Fluoxetin::CHEMBL41::CHEMBL1201082::Fluoxetine::US9120771, Fluoxetine Muscarinic acetylcholine receptor M5 Homo sapiens 2700 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=30130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=30130&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search RFX 4MM8,3GWV 3386 85147891 CHEMBL1201082CHEMBL41 DB00472 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163081 CN(C)CCCN1c2ccccc2CCc3c1cccc3 InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 BCGWQEUPMDMJNV-UHFFFAOYSA-N 50010859 CHEMBL11::Imipramin::IMIPRAMINE HYDROCHLORIDE::IMIPRAMINE PAMOATE Muscarinic acetylcholine receptor M5 Homo sapiens 83 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50010859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50010859&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search IXX 2Q72,7LWD,6G9B 3696 103923605 CHEMBL11 DB00458 C07049 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163082 CN(CCCN1c2ccccc2CCc2ccccc12)CC(=O)c1ccc(Cl)cc1 InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3 SAPNXPWPAUFAJU-UHFFFAOYSA-N 82437 CAS_23047-25-8::NSC_3947::US8629135, SW-06::Lofepramine Muscarinic acetylcholine receptor M5 Homo sapiens 460 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82437&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 3947 136350408 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163083 C(C1C[NH+]2CCC1CC2)N1c2ccccc2Sc2ccccc12 |THB:0:1:5.4:7.8,(14.51,-5.48,;15.79,-4.74,;17.21,-5.13,;17.6,-2.22,;20.16,-.74,;19.42,.54,;16.17,-1.84,;14.72,-.36,;16,.37,;14.51,-6.96,;15.79,-7.7,;17.11,-6.91,;18.45,-7.67,;18.45,-9.21,;17.11,-9.97,;15.79,-9.18,;14.51,-9.92,;13.22,-9.18,;11.9,-9.97,;10.56,-9.21,;10.56,-7.67,;11.9,-6.91,;13.22,-7.7,)| 28347 Mequitazine::3-(10H-phenothiazin-10-ylmethyl)-1-azabicyclo[2.2.2]octan-1-ium::ZINC01567421, 6 Muscarinic acetylcholine receptor M5 Homo sapiens 11 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=28347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=28347&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 25263218 58097536 C12755 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163084 c1ccc(cc1)[C@H](CCN)Oc2ccc(cc2)C(F)(F)F InChI=1S/C16H16F3NO/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12/h1-9,15H,10-11,20H2 WIQRCHMSJFFONW-UHFFFAOYSA-N 50254790 NORFLUOXETINE::CHEMBL465123::(S)-Norfluoxetine Muscarinic acetylcholine receptor M5 Homo sapiens 2200 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50254790 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50254790&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 405 4XDK 3058751 104106938 CHEMBL465123 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163085 [#6]-[#7]-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12 InChI=1S/C19H8N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-10H UDDYRZAAZAXGQW-UHFFFAOYSA-N 112777 NORTRIPTYLINE::US8629135, SW-02 Muscarinic acetylcholine receptor M5 Homo sapiens 97 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=112777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=112777&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 4543 194690518 DB00540 C07274 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163086 CN(C)CCOC(c1ccccc1)c1ccccc1C InChI=1S/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3 QVYRGXJJSLMXQH-UHFFFAOYSA-N 50062614 Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine::Orphengesic::Norflex::CHEMBL900::Disipal::Invagesic::N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine::Norgesic::ORPHENADRINE Muscarinic acetylcholine receptor M5 Homo sapiens 129 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50062614&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 4601 103958137 CHEMBL900 DB01173 C07935 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163087 c1cc(ccc1[C@@H]2CCNC[C@H]2COc3ccc4c(c3)OCO4)F InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2 AHOUBRCZNHFOSL-UHFFFAOYSA-N 22416 PAROXETINE::CHEMBL490::(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::(3S,4R)-3-[(2H-1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine::[3H]Paroxetine::US09969700, Paroxetine::US9944618, Compound ID No. 182 Muscarinic acetylcholine receptor M5 Homo sapiens 650 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=22416&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 8PR 6F6I,7OIH,6DZW,6AWN,4JLT,3V5W,4MM4,6VRH,5I6X,4L9I 43815 49846231 CHEMBL490 DB00715 C07415 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163088 c1ccc(cc1)C(c2ccccc2)(C(=O)O)O InChI=1S/C14H12O3/c15-13(16)14(17,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,17H,(H,15,16) UKXSKSHDVLQNKG-UHFFFAOYSA-N 81768 BENZYLIC ACID::NSC_5311391::CAS_6581-06-2::Quinuclidinyl benzilate Muscarinic acetylcholine receptor M5 Homo sapiens 0.065 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81768&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 0UT 4HNC 6463 131342342 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163089 CN[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc12 InChI=1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3 VGKDLMBJGBXTGI-UHFFFAOYSA-N 82217 [4-(3,4-Dichloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine::SERTRALINE::CHEMBL284994::CP-52003 Muscarinic acetylcholine receptor M5 Homo sapiens 1900 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82217&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 9882979 136350189 CHEMBL284994 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163090 Clc1cccc(c1)N1CCN(CCCn2nc3ccccn3c2=O)CC1 InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2 PHLBKPHSAVXXEF-UHFFFAOYSA-N 50073444 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one::CHEMBL621::TRAZODONE Muscarinic acetylcholine receptor M5 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50073444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50073444&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 5533 103966838 CHEMBL621 DB00656 C07156 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7 163091 COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1 InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 PNVNVHUZROJLTJ-UHFFFAOYSA-N 82071 NSC_62923::WY-45030::VENLAFAXINE::CAS_93413-69-5::Venlafaxine hydrochloride::CAS_99300-78-4::WY-45655 Muscarinic acetylcholine receptor M5 Homo sapiens >10000 PDSP Ki 10.1016/0006-2952(93)90211-e 10.7270/Q2F76B2C 8100134 Stanton, T; Bolden-Watson, C; Cusack, B; Richelson, E 12/9/1993 1/2/2012 Mayo Foundation http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=82071 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000212&target=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=82071&enzyme=Muscarinic+acetylcholine+receptor+M5&column=ki&startPg=0&Increment=50&submit=Search 5656 131342645 DB00285 C07187 1 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP 6OL9 Muscarinic acetylcholine receptor M5 ACM5_HUMAN P08912 Q96RG7