BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 50061692 NC(=O)N(O)CC1COc2ccc(Oc3ccccc3)cc2C1 InChI=1S/C17H18N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-7,9,12,21H,8,10-11H2,(H2,18,20) VYHCNJDGKCKCIJ-UHFFFAOYSA-N 50042504 N-hydroxy-N-[(6-phenoxy-3,4-dihydro-2H-chromen-3-yl)methyl]urea::CHEMBL422430 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 79 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042504 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042504&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971315 103974100 CHEMBL422430 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061693 COc1ccc2CC(CN(O)C(N)=O)COc2c1 InChI=1S/C12H16N2O4/c1-17-10-3-2-9-4-8(6-14(16)12(13)15)7-18-11(9)5-10/h2-3,5,8,16H,4,6-7H2,1H3,(H2,13,15) IREKZYFEDQPJLP-UHFFFAOYSA-N 50042527 N-hydroxy-N-[(7-methoxy-3,4-dihydro-2H-chromen-3-yl)methyl]urea::CHEMBL331483 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens >3000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042527&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971318 103974123 CHEMBL331483 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061694 CCCNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:9| InChI=1S/C20H22N2O4/c1-2-10-21-20(23)22(24)13-15-11-16-12-18(8-9-19(16)25-14-15)26-17-6-4-3-5-7-17/h3-9,11-12,24H,2,10,13-14H2,1H3,(H,21,23) MLTTVVZNUHJHEE-UHFFFAOYSA-N 50042497 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]-N'-propylurea::CHEMBL120347 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 39 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042497&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 44346017 103974093 CHEMBL120347 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061695 CCCC1Oc2ccc(Oc3ccccc3)cc2C=C1CN(O)C(N)=O |c:20| InChI=1S/C20H22N2O4/c1-2-6-18-15(13-22(24)20(21)23)11-14-12-17(9-10-19(14)26-18)25-16-7-4-3-5-8-16/h3-5,7-12,18,24H,2,6,13H2,1H3,(H2,21,23) ARCXCEDIOSEFIK-UHFFFAOYSA-N 50042499 N-hydroxy-N-[(6-phenyoxy-2-propyl-2H-chromen-3-yl)methyl]urea::CHEMBL118430 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 870 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042499&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971310 103974095 CHEMBL118430 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061696 NC(=O)N(O)CC1=Cc2cc(OCC3CCCCC3)ccc2OC1 |t:6| InChI=1S/C18H24N2O4/c19-18(21)20(22)10-14-8-15-9-16(6-7-17(15)24-12-14)23-11-13-4-2-1-3-5-13/h6-9,13,22H,1-5,10-12H2,(H2,19,21) SESCIILTRFSDNL-UHFFFAOYSA-N 50042517 N-(6-Cyclohexylmethoxy-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL118393 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 1390 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042517 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042517&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971281 103974113 CHEMBL118393 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061697 CCCCCCCc1ccc2OCC(CN(O)C(N)=O)=Cc2c1 |c:19| InChI=1S/C18H26N2O3/c1-2-3-4-5-6-7-14-8-9-17-16(10-14)11-15(13-23-17)12-20(22)18(19)21/h8-11,22H,2-7,12-13H2,1H3,(H2,19,21) ZVLVTOCEPANPQW-UHFFFAOYSA-N 50042505 N-[(6-heptyl-2H-chromen-3-yl)methyl]-N-hydroxyurea::CHEMBL118956 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 370 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042505 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042505&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971300 103974101 CHEMBL118956 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061698 NC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:6| InChI=1S/C17H15FN2O4/c18-13-1-3-14(4-2-13)24-15-5-6-16-12(8-15)7-11(10-23-16)9-20(22)17(19)21/h1-8,22H,9-10H2,(H2,19,21) SRDYWARPTRRGIS-UHFFFAOYSA-N 50042509 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxyurea::CHEMBL330889 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 42 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042509&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971283 103974105 CHEMBL330889 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061699 CC1(C)Oc2ccc(Oc3ccccc3)cc2C=C1CN(O)C(N)=O |c:19| InChI=1S/C19H20N2O4/c1-19(2)14(12-21(23)18(20)22)10-13-11-16(8-9-17(13)25-19)24-15-6-4-3-5-7-15/h3-11,23H,12H2,1-2H3,(H2,20,22) MQVRRZMLCHJUOG-UHFFFAOYSA-N 50042496 N-[(2,2-dimethyl-6-phenyoxy-2H-chromen-3-yl)methyl]-N-hydroxyurea::CHEMBL119499 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 440 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042496&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971312 103974092 CHEMBL119499 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061700 CC1Oc2ccc(Oc3ccccc3)cc2C=C1CN(O)C(N)=O |c:18| InChI=1S/C18H18N2O4/c1-12-14(11-20(22)18(19)21)9-13-10-16(7-8-17(13)23-12)24-15-5-3-2-4-6-15/h2-10,12,22H,11H2,1H3,(H2,19,21) FIGIZBVLAXGLJQ-UHFFFAOYSA-N 50042518 N-hydroxy-N-[(2-methyl-6-phenyoxy-2H-chromen-3-yl)methyl]urea::CHEMBL332092 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 120 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042518 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042518&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971309 103974114 CHEMBL332092 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061701 ON(CC1=Cc2cc(Oc3ccccc3)ccc2OC1)C(=O)NCc1ccccc1 |t:3| InChI=1S/C24H22N2O4/c27-24(25-15-18-7-3-1-4-8-18)26(28)16-19-13-20-14-22(11-12-23(20)29-17-19)30-21-9-5-2-6-10-21/h1-14,28H,15-17H2,(H,25,27) CEFNSSXWJKNYCE-UHFFFAOYSA-N 50042494 N-hydroxy-N'-methyl-N-[(6-phenoxy-2H-chromen-3-yl)benzyl]urea::CHEMBL332015 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 440 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042494&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971293 103974090 CHEMBL332015 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061702 CC(N(O)C(N)=O)C1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:7| InChI=1S/C18H18N2O4/c1-12(20(22)18(19)21)14-9-13-10-16(7-8-17(13)23-11-14)24-15-5-3-2-4-6-15/h2-10,12,22H,11H2,1H3,(H2,19,21) PXWSVVCWUZNEOL-UHFFFAOYSA-N 50042520 N-hydroxy-N-[1-(6-phenoxy-2H-chromen-3-yl)ethyl]urea::CHEMBL421423 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 260 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042520 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042520&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971314 103974116 CHEMBL421423 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061703 CCNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:8| InChI=1S/C19H20N2O4/c1-2-20-19(22)21(23)12-14-10-15-11-17(8-9-18(15)24-13-14)25-16-6-4-3-5-7-16/h3-11,23H,2,12-13H2,1H3,(H,20,22) WHTMYCKABDGZJG-UHFFFAOYSA-N 50042521 N'-ethyl-N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL120582 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 24 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042521&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971287 103974117 CHEMBL120582 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061704 ON(CC1=Cc2cc(Oc3ccccc3)ccc2OC1)C(=O)Nc1ccccc1 |t:3| InChI=1S/C23H20N2O4/c26-23(24-19-7-3-1-4-8-19)25(27)15-17-13-18-14-21(11-12-22(18)28-16-17)29-20-9-5-2-6-10-20/h1-14,27H,15-16H2,(H,24,26) QKSNUAVDJOQQGK-UHFFFAOYSA-N 50042506 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]-N'-phenylurea::CHEMBL118786 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 250 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042506 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042506&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971292 103974102 CHEMBL118786 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061705 CCCCCCCc1ccc2OCC(CN(O)C(N)=O)=Cc2c1 |c:19| InChI=1S/C18H26N2O3/c1-2-3-4-5-6-7-14-8-9-17-16(10-14)11-15(13-23-17)12-20(22)18(19)21/h8-11,22H,2-7,12-13H2,1H3,(H2,19,21) ZVLVTOCEPANPQW-UHFFFAOYSA-N 50042505 N-[(6-heptyl-2H-chromen-3-yl)methyl]-N-hydroxyurea::CHEMBL118956 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 310 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042505 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042505&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971300 103974101 CHEMBL118956 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061706 CC1Oc2ccc(OCc3ccccc3)cc2C=C1CN(O)C(N)=O |c:19| InChI=1S/C19H20N2O4/c1-13-16(11-21(23)19(20)22)9-15-10-17(7-8-18(15)25-13)24-12-14-5-3-2-4-6-14/h2-10,13,23H,11-12H2,1H3,(H2,20,22) XYROCJNDELRQQB-UHFFFAOYSA-N 50042519 N-(6-Benzyloxy-2-methyl-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL120745 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 260 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042519 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042519&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971308 103974115 CHEMBL120745 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061707 CC(N(O)C(N)=O)c1cc2ccccc2s1 InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) MWLSOWXNZPKENC-UHFFFAOYSA-N 50000541 Leutrol::CHEMBL93::N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea::(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea::N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea::Zyflo (TN)::1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea::ZILEUTON Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 1800 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000541&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 60490 103915089 CHEMBL93 DB00744 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061708 CC1Oc2ccc(OCc3ccccc3)cc2C=C1CN(O)C(N)=O |c:19| InChI=1S/C19H20N2O4/c1-13-16(11-21(23)19(20)22)9-15-10-17(7-8-18(15)25-13)24-12-14-5-3-2-4-6-14/h2-10,13,23H,11-12H2,1H3,(H2,20,22) XYROCJNDELRQQB-UHFFFAOYSA-N 50042519 N-(6-Benzyloxy-2-methyl-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL120745 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 220 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042519 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042519&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971308 103974115 CHEMBL120745 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061709 NC(=O)N(O)CC1=Cc2cc(OCc3ccc(cc3)C(F)(F)F)ccc2OC1 |t:6| InChI=1S/C19H17F3N2O4/c20-19(21,22)15-3-1-12(2-4-15)10-27-16-5-6-17-14(8-16)7-13(11-28-17)9-24(26)18(23)25/h1-8,26H,9-11H2,(H2,23,25) IGMADJRUJCQGKS-UHFFFAOYSA-N 50042523 N-[6-(4-Trifluoromethyl-benzyloxy)-2H-chromen-3-ylmethyl]-hydroxylurea::CHEMBL333100 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 430 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042523&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971279 103974119 CHEMBL333100 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061710 COc1ccc2OCC(CN(O)C(N)=O)=Cc2c1 |c:14| InChI=1S/C12H14N2O4/c1-17-10-2-3-11-9(5-10)4-8(7-18-11)6-14(16)12(13)15/h2-5,16H,6-7H2,1H3,(H2,13,15) RQCRACKRJFXMBX-UHFFFAOYSA-N 50042525 N-(6-Methoxy-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL122530 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 3600 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042525 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042525&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971277 103974121 CHEMBL122530 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061711 CCCCNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:10| InChI=1S/C21H24N2O4/c1-2-3-11-22-21(24)23(25)14-16-12-17-13-19(9-10-20(17)26-15-16)27-18-7-5-4-6-8-18/h4-10,12-13,25H,2-3,11,14-15H2,1H3,(H,22,24) DSHMDPQTDXKKIG-UHFFFAOYSA-N 50042503 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]-N'-butylurea::CHEMBL331931 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 65 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042503&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971290 103974099 CHEMBL331931 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061712 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-9,21H,10-11H2,(H2,18,20) FPOBKZCHKXONBB-UHFFFAOYSA-N 50042493 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CGS-23885::CHEMBL116719 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 48 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042493&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 131820 103974089 CHEMBL116719 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061713 CCOC(=O)CNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:12| InChI=1S/C21H22N2O6/c1-2-27-20(24)12-22-21(25)23(26)13-15-10-16-11-18(8-9-19(16)28-14-15)29-17-6-4-3-5-7-17/h3-11,26H,2,12-14H2,1H3,(H,22,25) SUINSFHKXYSEPL-UHFFFAOYSA-N 50042522 ethyl [({hydroxy[(6-phenoxy-2H-chromen-3-yl)methyl]amino}carbonyl)amino]acetate::CHEMBL119069 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 68 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042522&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971295 103974118 CHEMBL119069 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061714 ON(CC1=Cc2cc(Oc3ccccc3)ccc2OC1)C(=O)NCc1ccccc1 |t:3| InChI=1S/C24H22N2O4/c27-24(25-15-18-7-3-1-4-8-18)26(28)16-19-13-20-14-22(11-12-23(20)29-17-19)30-21-9-5-2-6-10-21/h1-14,28H,15-17H2,(H,25,27) CEFNSSXWJKNYCE-UHFFFAOYSA-N 50042494 N-hydroxy-N'-methyl-N-[(6-phenoxy-2H-chromen-3-yl)benzyl]urea::CHEMBL332015 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 440 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042494&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971293 103974090 CHEMBL332015 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061715 CCCC1Oc2ccc(Oc3ccccc3)cc2C=C1CN(O)C(N)=O |c:20| InChI=1S/C20H22N2O4/c1-2-6-18-15(13-22(24)20(21)23)11-14-12-17(9-10-19(14)26-18)25-16-7-4-3-5-8-16/h3-5,7-12,18,24H,2,6,13H2,1H3,(H2,21,23) ARCXCEDIOSEFIK-UHFFFAOYSA-N 50042499 N-hydroxy-N-[(6-phenyoxy-2-propyl-2H-chromen-3-yl)methyl]urea::CHEMBL118430 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 880 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042499 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042499&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971310 103974095 CHEMBL118430 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061716 CC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C18H17NO4/c1-13(20)19(21)11-14-9-15-10-17(7-8-18(15)22-12-14)23-16-5-3-2-4-6-16/h2-10,21H,11-12H2,1H3 GLFMNGMSGIXJAK-UHFFFAOYSA-N 50042507 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]acetamide::CHEMBL118914 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 120 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042507&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971296 103974103 CHEMBL118914 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061717 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-9,21H,10-11H2,(H2,18,20) FPOBKZCHKXONBB-UHFFFAOYSA-N 50042493 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CGS-23885::CHEMBL116719 Prostaglandin G/H synthase 1/2 Homo sapiens 36000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50000882&target=Prostaglandin+G%2FH+synthase+1%2F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042493&enzyme=Prostaglandin+G%2FH+synthase+1%2F2&column=ki&startPg=0&Increment=50&submit=Search 131820 103974089 CHEMBL116719 2 MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL 5F1A,5IKV,5IKT,5IKR,5IKQ,5F19,3MDL,4PH9 Prostaglandin G/H synthase 2 PGH2_HUMAN P35354 A8K802 Q16876 MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL 6Y3C,1PTH,1PGG,1PGF,1PGE,1IGZ,1IGX,1FE2 Prostaglandin G/H synthase 1 PGH1_HUMAN P23219 A8K1V7 B4DHQ2 B4E2S5 Q15122 Q3HY28 Q3HY29 Q5T7T6 Q5T7T7 Q5T7T8 50061718 CC(C)NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:9| InChI=1S/C20H22N2O4/c1-14(2)21-20(23)22(24)12-15-10-16-11-18(8-9-19(16)25-13-15)26-17-6-4-3-5-7-17/h3-11,14,24H,12-13H2,1-2H3,(H,21,23) HYKGMNOZTPIPSO-UHFFFAOYSA-N 50042524 N-hydroxy-N'-isopropyl-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL331062 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 49 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042524 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042524&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971289 103974120 CHEMBL331062 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061719 CC(N(O)C(N)=O)c1cc2ccccc2s1 InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) MWLSOWXNZPKENC-UHFFFAOYSA-N 50000541 Leutrol::CHEMBL93::N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea::(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea::N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea::Zyflo (TN)::1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea::ZILEUTON Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 2200 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000541&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 60490 103915089 CHEMBL93 DB00744 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061720 ON(CC1=Cc2cc(Oc3ccccc3)ccc2OC1)C(=O)Nc1ccccc1 |t:3| InChI=1S/C23H20N2O4/c26-23(24-19-7-3-1-4-8-19)25(27)15-17-13-18-14-21(11-12-22(18)28-16-17)29-20-9-5-2-6-10-20/h1-14,27H,15-16H2,(H,24,26) QKSNUAVDJOQQGK-UHFFFAOYSA-N 50042506 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]-N'-phenylurea::CHEMBL118786 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 240 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042506 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042506&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971292 103974102 CHEMBL118786 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061721 NC(=O)N(O)CC1=Cc2cc(ccc2OC1)-c1ccccc1 |t:6| InChI=1S/C17H16N2O3/c18-17(20)19(21)10-12-8-15-9-14(6-7-16(15)22-11-12)13-4-2-1-3-5-13/h1-9,21H,10-11H2,(H2,18,20) OXCDKLHAYPVXFO-UHFFFAOYSA-N 50042526 N-hydroxy-N-[(6-phenyl-2H-chromen-3-yl)methyl]urea::CHEMBL122125 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 240 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042526 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042526&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971302 103974122 CHEMBL122125 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061722 CC(N(O)C(N)=O)c1cc2ccccc2s1 InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) MWLSOWXNZPKENC-UHFFFAOYSA-N 50000541 Leutrol::CHEMBL93::N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea::(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea::N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea::Zyflo (TN)::1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea::ZILEUTON Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 840 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000541&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 60490 103915089 CHEMBL93 DB00744 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061723 NC(=O)N(O)CC1=Cc2cc(Br)ccc2OC1 |t:6| InChI=1S/C11H11BrN2O3/c12-9-1-2-10-8(4-9)3-7(6-17-10)5-14(16)11(13)15/h1-4,16H,5-6H2,(H2,13,15) ATSJRCBQGLUOCE-UHFFFAOYSA-N 50042513 N-[(6-bromo-2H-chromen-3-yl)methyl]-N-hydroxyurea::CHEMBL331748 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 1400 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042513 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042513&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971301 103974109 CHEMBL331748 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061724 CCOC(=O)CNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:12| InChI=1S/C21H22N2O6/c1-2-27-20(24)12-22-21(25)23(26)13-15-10-16-11-18(8-9-19(16)28-14-15)29-17-6-4-3-5-7-17/h3-11,26H,2,12-14H2,1H3,(H,22,25) SUINSFHKXYSEPL-UHFFFAOYSA-N 50042522 ethyl [({hydroxy[(6-phenoxy-2H-chromen-3-yl)methyl]amino}carbonyl)amino]acetate::CHEMBL119069 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 74 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042522&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971295 103974118 CHEMBL119069 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061725 COc1ccc2C=C(COc2c1)C(=O)N(C)O |c:6| InChI=1S/C12H13NO4/c1-13(15)12(14)9-5-8-3-4-10(16-2)6-11(8)17-7-9/h3-6,15H,7H2,1-2H3 BAVLTNAWWJMAPW-UHFFFAOYSA-N 50042516 7-Methoxy-2H-chromene-3-carboxylic acid hydroxy-methyl-amide::CHEMBL118377 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 410 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042516 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042516&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971255 103974112 CHEMBL118377 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061726 NC(=O)N(O)CC1=Cc2cc(OCc3ccccc3)ccc2OC1 |t:6| InChI=1S/C18H18N2O4/c19-18(21)20(22)10-14-8-15-9-16(6-7-17(15)24-12-14)23-11-13-4-2-1-3-5-13/h1-9,22H,10-12H2,(H2,19,21) OWWYHPLWXQHOIS-UHFFFAOYSA-N 50042492 N-(6-Benzyloxy-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL120132 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 380 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042492 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042492&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971278 103974088 CHEMBL120132 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061727 ON(CC1=Cc2cc(Oc3ccccc3)ccc2OC1)C(=O)NCC=C |t:3| InChI=1S/C20H20N2O4/c1-2-10-21-20(23)22(24)13-15-11-16-12-18(8-9-19(16)25-14-15)26-17-6-4-3-5-7-17/h2-9,11-12,24H,1,10,13-14H2,(H,21,23) KFNDCACNUFPHGC-UHFFFAOYSA-N 50042512 N'-allyl-N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL120454 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 44 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042512 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042512&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971294 103974108 CHEMBL120454 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061728 CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:7| InChI=1S/C18H17FN2O4/c1-20-18(22)21(23)10-12-8-13-9-16(6-7-17(13)24-11-12)25-15-4-2-14(19)3-5-15/h2-9,23H,10-11H2,1H3,(H,20,22) SOEOWQASEQWFFZ-UHFFFAOYSA-N 50042498 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea::CHEMBL333219 Prostaglandin G/H synthase 1/2 Ovis aries >100000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50006071&target=Prostaglandin+G%2FH+synthase+1%2F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042498&enzyme=Prostaglandin+G%2FH+synthase+1%2F2&column=ki&startPg=0&Increment=50&submit=Search 195771 103974094 CHEMBL333219 2 MLARALLLCAAVVCGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPDTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHYSYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTDIERGPAFTKGKNHGVDLSHVYGESLERQHNRRLFKDGKMKYQMINGEMYPPTVKDTQVEMIYPPHIPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGVTQFVESFTRQIAGRVAGRRNLPAAVEKVSKASLDQSREMKYQSFNEYRKRFLLKPYESFEELTGEKEMAAELEALYGDIDAMELYPALLVEKPAPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEVGFKIINTASIQSLICSNVKGCPFTSFSVQDAHLTKTVTINASSSHSGLDDINPTVLLKERSTEL 4M11,3NTG,1DDX Prostaglandin G/H synthase 2 PGH2_SHEEP P79208 MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL 5WBE,5U6X,1U67,7JXT Prostaglandin G/H synthase 1 PGH1_SHEEP P05979 50061729 CC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C18H17NO4/c1-13(20)19(21)11-14-9-15-10-17(7-8-18(15)22-12-14)23-16-5-3-2-4-6-16/h2-10,21H,11-12H2,1H3 GLFMNGMSGIXJAK-UHFFFAOYSA-N 50042507 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]acetamide::CHEMBL118914 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 86 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042507&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971296 103974103 CHEMBL118914 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061730 COc1ccc2CC(CN(O)C(N)=O)COc2c1 InChI=1S/C12H16N2O4/c1-17-10-3-2-9-4-8(6-14(16)12(13)15)7-18-11(9)5-10/h2-3,5,8,16H,4,6-7H2,1H3,(H2,13,15) IREKZYFEDQPJLP-UHFFFAOYSA-N 50042527 N-hydroxy-N-[(7-methoxy-3,4-dihydro-2H-chromen-3-yl)methyl]urea::CHEMBL331483 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens >3000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042527&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971318 103974123 CHEMBL331483 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061731 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1c1ccccc1 |t:6| InChI=1S/C23H20N2O4/c24-23(26)25(27)15-18-13-17-14-20(28-19-9-5-2-6-10-19)11-12-21(17)29-22(18)16-7-3-1-4-8-16/h1-14,22,27H,15H2,(H2,24,26) AGWZVHUGWRALAD-UHFFFAOYSA-N 50042495 N-[(2,6-diphenyl-2H-chromen-3-yl)methyl]-N-hydroxyurea::CHEMBL120362 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 310 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042495&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971311 103974091 CHEMBL120362 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061732 CN(O)C(=O)C1=Cc2cc(OCc3ccccc3)ccc2OC1 |t:5| InChI=1S/C18H17NO4/c1-19(21)18(20)15-9-14-10-16(7-8-17(14)23-12-15)22-11-13-5-3-2-4-6-13/h2-10,21H,11-12H2,1H3 UTPKHPOITVMUBJ-UHFFFAOYSA-N 50042501 6-Benzyloxy-2H-chromene-3-carboxylic acid hydroxy-methyl-amide::CHEMBL118212 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 100 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042501 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042501&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971256 103974097 CHEMBL118212 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061733 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-9,21H,10-11H2,(H2,18,20) FPOBKZCHKXONBB-UHFFFAOYSA-N 50042493 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CGS-23885::CHEMBL116719 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 43 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042493&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 131820 103974089 CHEMBL116719 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50061734 CNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:7| InChI=1S/C18H18N2O4/c1-19-18(21)20(22)11-13-9-14-10-16(7-8-17(14)23-12-13)24-15-5-3-2-4-6-15/h2-10,22H,11-12H2,1H3,(H,19,21) ADEXLPGNFPLCCW-UHFFFAOYSA-N 50042500 N-hydroxy-N'-methyl-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL118929 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 36 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042500&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971286 103974096 CHEMBL118929 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067726 CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:7| InChI=1S/C18H17FN2O4/c1-20-18(22)21(23)10-12-8-13-9-16(6-7-17(13)24-11-12)25-15-4-2-14(19)3-5-15/h2-9,23H,10-11H2,1H3,(H,20,22) SOEOWQASEQWFFZ-UHFFFAOYSA-N 50042498 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea::CHEMBL333219 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 45 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042498&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 195771 103974094 CHEMBL333219 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067727 NC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:6| InChI=1S/C17H15FN2O4/c18-13-1-3-14(4-2-13)24-15-5-6-16-12(8-15)7-11(10-23-16)9-20(22)17(19)21/h1-8,22H,9-10H2,(H2,19,21) SRDYWARPTRRGIS-UHFFFAOYSA-N 50042509 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxyurea::CHEMBL330889 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 49 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042509&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971283 103974105 CHEMBL330889 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067731 NC(=S)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O3S/c18-17(23)19(20)10-12-8-13-9-15(6-7-16(13)21-11-12)22-14-4-2-1-3-5-14/h1-9,20H,10-11H2,(H2,18,23) CHIISUNKGCYISU-UHFFFAOYSA-N 50042508 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]thiourea::CHEMBL118842 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 200 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042508 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042508&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971285 103974104 CHEMBL118842 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067732 CCCNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:9| InChI=1S/C20H22N2O4/c1-2-10-21-20(23)22(24)13-15-11-16-12-18(8-9-19(16)25-14-15)26-17-6-4-3-5-7-17/h3-9,11-12,24H,2,10,13-14H2,1H3,(H,21,23) MLTTVVZNUHJHEE-UHFFFAOYSA-N 50042497 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]-N'-propylurea::CHEMBL120347 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 34 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042497&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 44346017 103974093 CHEMBL120347 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067736 CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:7| InChI=1S/C18H17FN2O4/c1-20-18(22)21(23)10-12-8-13-9-16(6-7-17(13)24-11-12)25-15-4-2-14(19)3-5-15/h2-9,23H,10-11H2,1H3,(H,20,22) SOEOWQASEQWFFZ-UHFFFAOYSA-N 50042498 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea::CHEMBL333219 Polyunsaturated fatty acid lipoxygenase ALOX12 Homo sapiens 410 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5792&target=Polyunsaturated+fatty+acid+lipoxygenase+ALOX12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042498&enzyme=Polyunsaturated+fatty+acid+lipoxygenase+ALOX12&column=ki&startPg=0&Increment=50&submit=Search 195771 103974094 CHEMBL333219 1 MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI Polyunsaturated fatty acid lipoxygenase ALOX12 LOX12_HUMAN P18054 O95569 Q6ISF8 Q9UQM4 50067740 CC(C)(C)NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:10| InChI=1S/C21H24N2O4/c1-21(2,3)22-20(24)23(25)13-15-11-16-12-18(9-10-19(16)26-14-15)27-17-7-5-4-6-8-17/h4-12,25H,13-14H2,1-3H3,(H,22,24) YFMRPLLDOHHMCW-UHFFFAOYSA-N 50042502 N-hydroxy-N'-tertbutyl-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL118493 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 4400 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042502 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042502&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971291 103974098 CHEMBL118493 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067742 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-9,21H,10-11H2,(H2,18,20) FPOBKZCHKXONBB-UHFFFAOYSA-N 50042493 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CGS-23885::CHEMBL116719 Polyunsaturated fatty acid lipoxygenase ALOX12 Homo sapiens 640 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5792&target=Polyunsaturated+fatty+acid+lipoxygenase+ALOX12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042493&enzyme=Polyunsaturated+fatty+acid+lipoxygenase+ALOX12&column=ki&startPg=0&Increment=50&submit=Search 131820 103974089 CHEMBL116719 1 MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI Polyunsaturated fatty acid lipoxygenase ALOX12 LOX12_HUMAN P18054 O95569 Q6ISF8 Q9UQM4 50067747 CC(C)(C)NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:10| InChI=1S/C21H24N2O4/c1-21(2,3)22-20(24)23(25)13-15-11-16-12-18(9-10-19(16)26-14-15)27-17-7-5-4-6-8-17/h4-12,25H,13-14H2,1-3H3,(H,22,24) YFMRPLLDOHHMCW-UHFFFAOYSA-N 50042502 N-hydroxy-N'-tertbutyl-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL118493 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 6200 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042502 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042502&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971291 103974098 CHEMBL118493 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067749 CNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:7| InChI=1S/C18H18N2O4/c1-19-18(21)20(22)11-13-9-14-10-16(7-8-17(14)23-12-13)24-15-5-3-2-4-6-15/h2-10,22H,11-12H2,1H3,(H,19,21) ADEXLPGNFPLCCW-UHFFFAOYSA-N 50042500 N-hydroxy-N'-methyl-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL118929 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 41 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042500 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042500&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971286 103974096 CHEMBL118929 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067752 ON(CC1=Cc2cc(Oc3ccccc3)ccc2OC1)C(=O)NCC=C |t:3| InChI=1S/C20H20N2O4/c1-2-10-21-20(23)22(24)13-15-11-16-12-18(8-9-19(16)25-14-15)26-17-6-4-3-5-7-17/h2-9,11-12,24H,1,10,13-14H2,(H,21,23) KFNDCACNUFPHGC-UHFFFAOYSA-N 50042512 N'-allyl-N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL120454 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 37 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042512 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042512&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971294 103974108 CHEMBL120454 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067755 CCCCCCOc1ccc2OCC(CN(O)C(N)=O)=Cc2c1 |c:19| InChI=1S/C17H24N2O4/c1-2-3-4-5-8-22-15-6-7-16-14(10-15)9-13(12-23-16)11-19(21)17(18)20/h6-7,9-10,21H,2-5,8,11-12H2,1H3,(H2,18,20) HVXJPWACPZJWIP-UHFFFAOYSA-N 50042510 N-(6-Hexyloxy-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL121846 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 280 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042510&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971280 103974106 CHEMBL121846 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067756 CC(C)(C)c1ccc(Oc2ccc3OCC(CN(O)C(N)=O)=Cc3c2)cc1 |c:21| InChI=1S/C21H24N2O4/c1-21(2,3)16-4-6-17(7-5-16)27-18-8-9-19-15(11-18)10-14(13-26-19)12-23(25)20(22)24/h4-11,25H,12-13H2,1-3H3,(H2,22,24) PLFNZRPEZMNURP-UHFFFAOYSA-N 50042515 N-hydroxy-N-{[6-(4-tertbutylphenoxy)-2H-chromen-3-yl]methyl}urea::CHEMBL118843 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 1900 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042515 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042515&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971284 103974111 CHEMBL118843 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067758 CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:7| InChI=1S/C18H17FN2O4/c1-20-18(22)21(23)10-12-8-13-9-16(6-7-17(13)24-11-12)25-15-4-2-14(19)3-5-15/h2-9,23H,10-11H2,1H3,(H,20,22) SOEOWQASEQWFFZ-UHFFFAOYSA-N 50042498 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea::CHEMBL333219 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 410 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042498&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 195771 103974094 CHEMBL333219 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067759 NC(=O)N(O)CC1=Cc2cc(Br)ccc2OC1 |t:6| InChI=1S/C11H11BrN2O3/c12-9-1-2-10-8(4-9)3-7(6-17-10)5-14(16)11(13)15/h1-4,16H,5-6H2,(H2,13,15) ATSJRCBQGLUOCE-UHFFFAOYSA-N 50042513 N-[(6-bromo-2H-chromen-3-yl)methyl]-N-hydroxyurea::CHEMBL331748 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 1400 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042513 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042513&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971301 103974109 CHEMBL331748 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067761 CN(O)C(=O)C1=Cc2ccccc2OC1 |t:5| InChI=1S/C11H11NO3/c1-12(14)11(13)9-6-8-4-2-3-5-10(8)15-7-9/h2-6,14H,7H2,1H3 PSYOHPSVDYJWGC-UHFFFAOYSA-N 50042514 2H-Chromene-3-carboxylic acid hydroxy-methyl-amide::CHEMBL324959 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 180 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042514 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042514&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971254 103974110 CHEMBL324959 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067763 CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:7| InChI=1S/C18H17FN2O4/c1-20-18(22)21(23)10-12-8-13-9-16(6-7-17(13)24-11-12)25-15-4-2-14(19)3-5-15/h2-9,23H,10-11H2,1H3,(H,20,22) SOEOWQASEQWFFZ-UHFFFAOYSA-N 50042498 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea::CHEMBL333219 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 51 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042498&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 195771 103974094 CHEMBL333219 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067764 NC(=O)N(O)CC1=Cc2cc(OCCCc3ccccc3)ccc2OC1 |t:6| InChI=1S/C20H22N2O4/c21-20(23)22(24)13-16-11-17-12-18(8-9-19(17)26-14-16)25-10-4-7-15-5-2-1-3-6-15/h1-3,5-6,8-9,11-12,24H,4,7,10,13-14H2,(H2,21,23) SDMFOFXWPYUZSS-UHFFFAOYSA-N 50042511 N-[6-(3-Phenyl-propoxy)-2H-chromen-3-ylmethyl]-hydroxylamine::CHEMBL325496 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 160 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042511 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042511&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971282 103974107 CHEMBL325496 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067766 CC(N(O)C(N)=O)c1cc2ccccc2s1 InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) MWLSOWXNZPKENC-UHFFFAOYSA-N 50000541 Leutrol::CHEMBL93::N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea::(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea::N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea::Zyflo (TN)::1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea::ZILEUTON Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 5120 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000541&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 60490 103915089 CHEMBL93 DB00744 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067768 CC(N(O)C(N)=O)C1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:7| InChI=1S/C18H18N2O4/c1-12(20(22)18(19)21)14-9-13-10-16(7-8-17(13)23-11-14)24-15-5-3-2-4-6-15/h2-10,12,22H,11H2,1H3,(H2,19,21) PXWSVVCWUZNEOL-UHFFFAOYSA-N 50042520 N-hydroxy-N-[1-(6-phenoxy-2H-chromen-3-yl)ethyl]urea::CHEMBL421423 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 200 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042520 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042520&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971314 103974116 CHEMBL421423 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067772 CC(N(O)C(N)=O)c1cc2ccccc2s1 InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) MWLSOWXNZPKENC-UHFFFAOYSA-N 50000541 Leutrol::CHEMBL93::N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea::(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea::N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea::Zyflo (TN)::1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea::ZILEUTON Prostaglandin G/H synthase 1/2 Ovis aries >100000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=50006071&target=Prostaglandin+G%2FH+synthase+1%2F2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000541&enzyme=Prostaglandin+G%2FH+synthase+1%2F2&column=ki&startPg=0&Increment=50&submit=Search 60490 103915089 CHEMBL93 DB00744 2 MLARALLLCAAVVCGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPDTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHYSYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTDIERGPAFTKGKNHGVDLSHVYGESLERQHNRRLFKDGKMKYQMINGEMYPPTVKDTQVEMIYPPHIPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGVTQFVESFTRQIAGRVAGRRNLPAAVEKVSKASLDQSREMKYQSFNEYRKRFLLKPYESFEELTGEKEMAAELEALYGDIDAMELYPALLVEKPAPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEVGFKIINTASIQSLICSNVKGCPFTSFSVQDAHLTKTVTINASSSHSGLDDINPTVLLKERSTEL 4M11,3NTG,1DDX Prostaglandin G/H synthase 2 PGH2_SHEEP P79208 MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL 5WBE,5U6X,1U67,7JXT Prostaglandin G/H synthase 1 PGH1_SHEEP P05979 50067773 CC1Oc2ccc(Oc3ccccc3)cc2C=C1CN(O)C(N)=O |c:18| InChI=1S/C18H18N2O4/c1-12-14(11-20(22)18(19)21)9-13-10-16(7-8-17(13)23-12)24-15-5-3-2-4-6-15/h2-10,12,22H,11H2,1H3,(H2,19,21) FIGIZBVLAXGLJQ-UHFFFAOYSA-N 50042518 N-hydroxy-N-[(2-methyl-6-phenyoxy-2H-chromen-3-yl)methyl]urea::CHEMBL332092 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 87 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042518 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042518&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971309 103974114 CHEMBL332092 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067775 CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:7| InChI=1S/C18H17FN2O4/c1-20-18(22)21(23)10-12-8-13-9-16(6-7-17(13)24-11-12)25-15-4-2-14(19)3-5-15/h2-9,23H,10-11H2,1H3,(H,20,22) SOEOWQASEQWFFZ-UHFFFAOYSA-N 50042498 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea::CHEMBL333219 Thromboxane-A synthase Rattus norvegicus >20000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001210&target=Thromboxane-A+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042498&enzyme=Thromboxane-A+synthase&column=ki&startPg=0&Increment=50&submit=Search 195771 103974094 CHEMBL333219 1 MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR Thromboxane-A synthase THAS_RAT P49430 50067778 CC(N(O)C(N)=O)c1cc2ccccc2s1 InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) MWLSOWXNZPKENC-UHFFFAOYSA-N 50000541 Leutrol::CHEMBL93::N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea::(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea::N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea::Zyflo (TN)::1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea::ZILEUTON Thromboxane-A synthase Rattus norvegicus >20000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001210&target=Thromboxane-A+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000541&enzyme=Thromboxane-A+synthase&column=ki&startPg=0&Increment=50&submit=Search 60490 103915089 CHEMBL93 DB00744 1 MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR Thromboxane-A synthase THAS_RAT P49430 50067779 NC(=O)N(O)CC1=Cc2cc(OCC3CCCCC3)ccc2OC1 |t:6| InChI=1S/C18H24N2O4/c19-18(21)20(22)10-14-8-15-9-16(6-7-17(15)24-12-14)23-11-13-4-2-1-3-5-13/h6-9,13,22H,1-5,10-12H2,(H2,19,21) SESCIILTRFSDNL-UHFFFAOYSA-N 50042517 N-(6-Cyclohexylmethoxy-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL118393 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 1360 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042517 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042517&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971281 103974113 CHEMBL118393 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067780 CCCCCCOc1ccc2OCC(CN(O)C(N)=O)=Cc2c1 |c:19| InChI=1S/C17H24N2O4/c1-2-3-4-5-8-22-15-6-7-16-14(10-15)9-13(12-23-16)11-19(21)17(18)20/h6-7,9-10,21H,2-5,8,11-12H2,1H3,(H2,18,20) HVXJPWACPZJWIP-UHFFFAOYSA-N 50042510 N-(6-Hexyloxy-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL121846 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 340 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042510&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971280 103974106 CHEMBL121846 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067781 NC(=O)N(O)CC1COc2ccc(Oc3ccccc3)cc2C1 InChI=1S/C17H18N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-7,9,12,21H,8,10-11H2,(H2,18,20) VYHCNJDGKCKCIJ-UHFFFAOYSA-N 50042504 N-hydroxy-N-[(6-phenoxy-3,4-dihydro-2H-chromen-3-yl)methyl]urea::CHEMBL422430 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 53.0 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042504 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042504&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971315 103974100 CHEMBL422430 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067782 CCCCNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:10| InChI=1S/C21H24N2O4/c1-2-3-11-22-21(24)23(25)14-16-12-17-13-19(9-10-20(17)26-15-16)27-18-7-5-4-6-8-18/h4-10,12-13,25H,2-3,11,14-15H2,1H3,(H,22,24) DSHMDPQTDXKKIG-UHFFFAOYSA-N 50042503 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]-N'-butylurea::CHEMBL331931 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 69.0 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042503 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042503&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971290 103974099 CHEMBL331931 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067785 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-9,21H,10-11H2,(H2,18,20) FPOBKZCHKXONBB-UHFFFAOYSA-N 50042493 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CGS-23885::CHEMBL116719 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 890 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042493&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 131820 103974089 CHEMBL116719 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067787 CC(C)NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:9| InChI=1S/C20H22N2O4/c1-14(2)21-20(23)22(24)12-15-10-16-11-18(8-9-19(16)25-13-15)26-17-6-4-3-5-7-17/h3-11,14,24H,12-13H2,1-2H3,(H,21,23) HYKGMNOZTPIPSO-UHFFFAOYSA-N 50042524 N-hydroxy-N'-isopropyl-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL331062 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 63 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042524 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042524&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971289 103974120 CHEMBL331062 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067789 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-9,21H,10-11H2,(H2,18,20) FPOBKZCHKXONBB-UHFFFAOYSA-N 50042493 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CGS-23885::CHEMBL116719 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 110 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042493&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 131820 103974089 CHEMBL116719 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067793 CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1 |t:7| InChI=1S/C18H17FN2O4/c1-20-18(22)21(23)10-12-8-13-9-16(6-7-17(13)24-11-12)25-15-4-2-14(19)3-5-15/h2-9,23H,10-11H2,1H3,(H,20,22) SOEOWQASEQWFFZ-UHFFFAOYSA-N 50042498 N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea::CHEMBL333219 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 110 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042498&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 195771 103974094 CHEMBL333219 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067795 NC(=O)N(O)CC1=Cc2cc(ccc2OC1)-c1ccccc1 |t:6| InChI=1S/C17H16N2O3/c18-17(20)19(21)10-12-8-15-9-14(6-7-16(15)22-11-12)13-4-2-1-3-5-13/h1-9,21H,10-11H2,(H2,18,20) OXCDKLHAYPVXFO-UHFFFAOYSA-N 50042526 N-hydroxy-N-[(6-phenyl-2H-chromen-3-yl)methyl]urea::CHEMBL122125 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 230 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042526 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042526&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971302 103974122 CHEMBL122125 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067796 NC(=S)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O3S/c18-17(23)19(20)10-12-8-13-9-15(6-7-16(13)21-11-12)22-14-4-2-1-3-5-14/h1-9,20H,10-11H2,(H2,18,23) CHIISUNKGCYISU-UHFFFAOYSA-N 50042508 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]thiourea::CHEMBL118842 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 180 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042508 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042508&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971285 103974104 CHEMBL118842 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067799 CC(N(O)C(N)=O)c1cc2ccccc2s1 InChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14) MWLSOWXNZPKENC-UHFFFAOYSA-N 50000541 Leutrol::CHEMBL93::N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea::(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea::N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea::Zyflo (TN)::1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea::ZILEUTON Polyunsaturated fatty acid lipoxygenase ALOX12 Homo sapiens 55000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50000541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5792&target=Polyunsaturated+fatty+acid+lipoxygenase+ALOX12&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50000541&enzyme=Polyunsaturated+fatty+acid+lipoxygenase+ALOX12&column=ki&startPg=0&Increment=50&submit=Search 60490 103915089 CHEMBL93 DB00744 1 MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI Polyunsaturated fatty acid lipoxygenase ALOX12 LOX12_HUMAN P18054 O95569 Q6ISF8 Q9UQM4 50067800 CN(O)C(=O)C1=Cc2cc(OCc3ccccc3)ccc2OC1 |t:5| InChI=1S/C18H17NO4/c1-19(21)18(20)15-9-14-10-16(7-8-17(14)23-12-15)22-11-13-5-3-2-4-6-13/h2-10,21H,11-12H2,1H3 UTPKHPOITVMUBJ-UHFFFAOYSA-N 50042501 6-Benzyloxy-2H-chromene-3-carboxylic acid hydroxy-methyl-amide::CHEMBL118212 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 61 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042501 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042501&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971256 103974097 CHEMBL118212 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067801 CN(O)C(=O)C1=Cc2ccccc2OC1 |t:5| InChI=1S/C11H11NO3/c1-12(14)11(13)9-6-8-4-2-3-5-10(8)15-7-9/h2-6,14H,7H2,1H3 PSYOHPSVDYJWGC-UHFFFAOYSA-N 50042514 2H-Chromene-3-carboxylic acid hydroxy-methyl-amide::CHEMBL324959 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 830 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042514 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042514&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971254 103974110 CHEMBL324959 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067802 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:6| InChI=1S/C17H16N2O4/c18-17(20)19(21)10-12-8-13-9-15(6-7-16(13)22-11-12)23-14-4-2-1-3-5-14/h1-9,21H,10-11H2,(H2,18,20) FPOBKZCHKXONBB-UHFFFAOYSA-N 50042493 N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CGS-23885::CHEMBL116719 Thromboxane-A synthase Rattus norvegicus >20000 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042493 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001210&target=Thromboxane-A+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042493&enzyme=Thromboxane-A+synthase&column=ki&startPg=0&Increment=50&submit=Search 131820 103974089 CHEMBL116719 1 MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR Thromboxane-A synthase THAS_RAT P49430 50067805 CC1(C)Oc2ccc(Oc3ccccc3)cc2C=C1CN(O)C(N)=O |c:19| InChI=1S/C19H20N2O4/c1-19(2)14(12-21(23)18(20)22)10-13-11-16(8-9-17(13)25-19)24-15-6-4-3-5-7-15/h3-11,23H,12H2,1-2H3,(H2,20,22) MQVRRZMLCHJUOG-UHFFFAOYSA-N 50042496 N-[(2,2-dimethyl-6-phenyoxy-2H-chromen-3-yl)methyl]-N-hydroxyurea::CHEMBL119499 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 310 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042496 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042496&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971312 103974092 CHEMBL119499 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067809 NC(=O)N(O)CC1=Cc2cc(OCc3ccc(cc3)C(F)(F)F)ccc2OC1 |t:6| InChI=1S/C19H17F3N2O4/c20-19(21,22)15-3-1-12(2-4-15)10-27-16-5-6-17-14(8-16)7-13(11-28-17)9-24(26)18(23)25/h1-8,26H,9-11H2,(H2,23,25) IGMADJRUJCQGKS-UHFFFAOYSA-N 50042523 N-[6-(4-Trifluoromethyl-benzyloxy)-2H-chromen-3-ylmethyl]-hydroxylurea::CHEMBL333100 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 490 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042523&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971279 103974119 CHEMBL333100 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067810 CCNC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1 |t:8| InChI=1S/C19H20N2O4/c1-2-20-19(22)21(23)12-14-10-15-11-17(8-9-18(15)24-13-14)25-16-6-4-3-5-7-16/h3-11,23H,2,12-13H2,1H3,(H,20,22) WHTMYCKABDGZJG-UHFFFAOYSA-N 50042521 N'-ethyl-N-hydroxy-N-[(6-phenoxy-2H-chromen-3-yl)methyl]urea::CHEMBL120582 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 27 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042521 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042521&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971287 103974117 CHEMBL120582 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067812 NC(=O)N(O)CC1=Cc2cc(Oc3ccccc3)ccc2OC1c1ccccc1 |t:6| InChI=1S/C23H20N2O4/c24-23(26)25(27)15-18-13-17-14-20(28-19-9-5-2-6-10-19)11-12-21(17)29-22(18)16-7-3-1-4-8-16/h1-14,22,27H,15H2,(H2,24,26) AGWZVHUGWRALAD-UHFFFAOYSA-N 50042495 N-[(2,6-diphenyl-2H-chromen-3-yl)methyl]-N-hydroxyurea::CHEMBL120362 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 320 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042495&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971311 103974091 CHEMBL120362 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067813 NC(=O)N(O)CC1=Cc2cc(OCCCc3ccccc3)ccc2OC1 |t:6| InChI=1S/C20H22N2O4/c21-20(23)22(24)13-16-11-17-12-18(8-9-19(17)26-14-16)25-10-4-7-15-5-2-1-3-6-15/h1-3,5-6,8-9,11-12,24H,4,7,10,13-14H2,(H2,21,23) SDMFOFXWPYUZSS-UHFFFAOYSA-N 50042511 N-[6-(3-Phenyl-propoxy)-2H-chromen-3-ylmethyl]-hydroxylamine::CHEMBL325496 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 130 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042511 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042511&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971282 103974107 CHEMBL325496 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50067814 CC(C)(C)c1ccc(Oc2ccc3OCC(CN(O)C(N)=O)=Cc3c2)cc1 |c:21| InChI=1S/C21H24N2O4/c1-21(2,3)16-4-6-17(7-5-16)27-18-8-9-19-15(11-18)10-14(13-26-19)12-23(25)20(22)24/h4-11,25H,12-13H2,1-3H3,(H2,22,24) PLFNZRPEZMNURP-UHFFFAOYSA-N 50042515 N-hydroxy-N-{[6-(4-tertbutylphenoxy)-2H-chromen-3-yl]methyl}urea::CHEMBL118843 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 2400 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042515 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042515&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971284 103974111 CHEMBL118843 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50673858 NC(=O)N(O)CC1=Cc2cc(OCc3ccccc3)ccc2OC1 |t:6| InChI=1S/C18H18N2O4/c19-18(21)20(22)10-14-8-15-9-16(6-7-17(15)24-12-14)23-11-13-4-2-1-3-5-13/h1-9,22H,10-12H2,(H2,19,21) OWWYHPLWXQHOIS-UHFFFAOYSA-N 50042492 N-(6-Benzyloxy-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL120132 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 440 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042492 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042492&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971278 103974088 CHEMBL120132 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50673859 COc1ccc2C=C(COc2c1)C(=O)N(C)O |c:6| InChI=1S/C12H13NO4/c1-13(15)12(14)9-5-8-3-4-10(16-2)6-11(8)17-7-9/h3-6,15H,7H2,1-2H3 BAVLTNAWWJMAPW-UHFFFAOYSA-N 50042516 7-Methoxy-2H-chromene-3-carboxylic acid hydroxy-methyl-amide::CHEMBL118377 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 400 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042516 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042516&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971255 103974112 CHEMBL118377 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14 50673860 COc1ccc2OCC(CN(O)C(N)=O)=Cc2c1 |c:14| InChI=1S/C12H14N2O4/c1-17-10-2-3-11-9(5-10)4-8(7-18-11)6-14(16)12(13)15/h2-5,16H,6-7H2,1H3,(H2,13,15) RQCRACKRJFXMBX-UHFFFAOYSA-N 50042525 N-(6-Methoxy-2H-chromen-3-ylmethyl)-hydroxylurea::CHEMBL122530 Polyunsaturated fatty acid 5-lipoxygenase Homo sapiens 3900 ChEMBL 10.1021/jm00075a013 10.7270/Q29G5KVC 8246226 Satoh, Y; Stanton, JL; Hutchison, AJ; Libby, AH; Kowalski, TJ; Lee, WH; White, DH; Kimble, EF 1/6/1994 11/10/2009 Ciba-Geigy http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042525 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2259&target=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042525&enzyme=Polyunsaturated+fatty+acid+5-lipoxygenase&column=ki&startPg=0&Increment=50&submit=Search 14971277 103974121 CHEMBL122530 1 MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDEELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLARDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVLNYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNGCNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDPCTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDFHVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECGLFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWEAIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYLTVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCWHLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPYYYLSPDRIPNSVAI Polyunsaturated fatty acid 5-lipoxygenase LOX5_HUMAN P09917 B7ZLS0 E5FPY5 E5FPY7 E5FPY8 Q5JQ14