BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 50059463 Nc1nc2c(Cc3ccc(Cl)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UUGHFFUUNJFXJA-UHFFFAOYSA-N 50046219 2-Amino-7-(4-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79410 Purine nucleoside phosphorylase Bos taurus 380 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046219&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778126 103977041 CHEMBL79410 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059464 Nc1nc2c(Cc3cccc(O)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)4-7-2-1-3-9(18)5-7/h1-3,5-6,15,18H,4H2,(H3,14,16,17,19) KFEIVJHPUHYGLV-UHFFFAOYSA-N 50046213 2-Amino-7-(3-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL82087 Purine nucleoside phosphorylase Bos taurus 274 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046213&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10467587 103977035 CHEMBL82087 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059465 Nc1nc2C(Cc3ccccc3)CNc2c(=O)[nH]1 InChI=1S/C13H14N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,9,15H,6-7H2,(H3,14,16,17,18) SRZKQXMAAAAYDI-UHFFFAOYSA-N 50046234 2-Amino-7-benzyl-3,4a,5,7a-tetrahydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL161609 Purine nucleoside phosphorylase Bos taurus 100 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046234 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046234&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929343 103977056 CHEMBL161609 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059466 Nc1nc2c(Cc3ccco3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4O2/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) YABIPPNOXRKWBX-UHFFFAOYSA-N 50046240 2-Amino-7-furan-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL351205 Purine nucleoside phosphorylase Bos taurus 313 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046240&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11776004 103977062 CHEMBL351205 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059467 Nc1nc2C(Cc3ccsc3)CNc2c(=O)[nH]1 InChI=1S/C11H12N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,5,7,13H,3-4H2,(H3,12,14,15,16) SKEKJWCUZBODGF-UHFFFAOYSA-N 50046239 2-Amino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159640 Purine nucleoside phosphorylase Bos taurus 15 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046239&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929345 103977061 CHEMBL159640 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059468 Nc1nc2c(Cc3cccc(O)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)4-7-2-1-3-9(18)5-7/h1-3,5-6,15,18H,4H2,(H3,14,16,17,19) KFEIVJHPUHYGLV-UHFFFAOYSA-N 50046213 2-Amino-7-(3-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL82087 Purine nucleoside phosphorylase Bos taurus 70 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046213&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10467587 103977035 CHEMBL82087 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059469 Nc1nc2c(Cc3ccc(Cl)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UUGHFFUUNJFXJA-UHFFFAOYSA-N 50046219 2-Amino-7-(4-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79410 Purine nucleoside phosphorylase Bos taurus 25 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046219&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778126 103977041 CHEMBL79410 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059470 Nc1nc2c(Cc3ccco3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4O2/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) YABIPPNOXRKWBX-UHFFFAOYSA-N 50046240 2-Amino-7-furan-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL351205 Purine nucleoside phosphorylase Bos taurus 83 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046240&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11776004 103977062 CHEMBL351205 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059471 Nc1nc2N(Cc3cccs3)CNc2c(=O)[nH]1 InChI=1S/C10H11N5OS/c11-10-13-8-7(9(16)14-10)12-5-15(8)4-6-2-1-3-17-6/h1-3,12H,4-5H2,(H3,11,13,14,16) UPNZQUYQZWHTQQ-UHFFFAOYSA-N 50046226 2-Amino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL345655 Purine nucleoside phosphorylase Bos taurus 2000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046226&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374593 103977048 CHEMBL345655 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059472 Nc1nc2c(Cc3cccc(Oc4ccccc4)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C19H16N4O2/c20-19-22-16-13(11-21-17(16)18(24)23-19)9-12-5-4-8-15(10-12)25-14-6-2-1-3-7-14/h1-8,10-11,21H,9H2,(H3,20,22,23,24) SZLVNGWVKLCDQQ-UHFFFAOYSA-N 50046244 2-Amino-7-(3-phenoxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159471 Purine nucleoside phosphorylase Bos taurus 147 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046244&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374526 103977066 CHEMBL159471 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059473 Nc1nc2c(Cc3ccc(Cl)c(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H10Cl2N4O/c14-8-2-1-6(4-9(8)15)3-7-5-17-11-10(7)18-13(16)19-12(11)20/h1-2,4-5,17H,3H2,(H3,16,18,19,20) FVPGRDMKNFHMAJ-UHFFFAOYSA-N 50046225 2-Amino-7-(3,4-dichloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL160043 Purine nucleoside phosphorylase Bos taurus 17 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046225&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10063910 103977047 CHEMBL160043 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059474 Nc1nc2c(Cc3cccc(c3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H11F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h1-3,5-6,19H,4H2,(H3,18,20,21,22) CBTABLJYKHBPFF-UHFFFAOYSA-N 50046232 2-Amino-7-(3-trifluoromethyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL354926 Purine nucleoside phosphorylase Bos taurus 190 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046232&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10040910 103977054 CHEMBL354926 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059475 Nc1nc2C(Cc3ccsc3)CNc2c(=O)[nH]1 InChI=1S/C11H12N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,5,7,13H,3-4H2,(H3,12,14,15,16) SKEKJWCUZBODGF-UHFFFAOYSA-N 50046239 2-Amino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159640 Purine nucleoside phosphorylase Bos taurus 0.067000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046239&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929345 103977061 CHEMBL159640 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059476 Nc1nc2c(Cc3cccc(c3)C(F)(F)F)c[nH]c2c(=O)[nH]1 InChI=1S/C14H11F3N4O/c15-14(16,17)9-3-1-2-7(5-9)4-8-6-19-11-10(8)20-13(18)21-12(11)22/h1-3,5-6,19H,4H2,(H3,18,20,21,22) CBTABLJYKHBPFF-UHFFFAOYSA-N 50046232 2-Amino-7-(3-trifluoromethyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL354926 Purine nucleoside phosphorylase Bos taurus 36 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046232&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10040910 103977054 CHEMBL354926 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059477 COc1cccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)c1 InChI=1S/C14H14N4O2/c1-20-10-4-2-3-8(6-10)5-9-7-16-12-11(9)17-14(15)18-13(12)19/h2-4,6-7,16H,5H2,1H3,(H3,15,17,18,19) DOQAZHCUONJLMW-UHFFFAOYSA-N 50046214 2-Amino-7-(3-methoxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL162751 Purine nucleoside phosphorylase Bos taurus 82 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046214&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10400926 103977036 CHEMBL162751 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059478 Nc1nc2c(Cc3cccc(F)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11FN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) WOWBUNTUMYSYSI-UHFFFAOYSA-N 50046233 2-Amino-7-(3-fluoro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159908 Purine nucleoside phosphorylase Bos taurus 220 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046233 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046233&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10061045 103977055 CHEMBL159908 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059479 Nc1nc2c(Cc3ccc(O)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-1-3-9(18)4-2-7/h1-4,6,15,18H,5H2,(H3,14,16,17,19) PZTAPFWQMIZJNG-UHFFFAOYSA-N 50046220 2-Amino-7-(4-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81731 Purine nucleoside phosphorylase Bos taurus 2300 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046220&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10106443 103977042 CHEMBL81731 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059480 Nc1nc2c(Cc3ccc(I)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11IN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) GFFQSWANLMANPJ-UHFFFAOYSA-N 50046245 2-Amino-7-(4-iodo-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL349615 Purine nucleoside phosphorylase Bos taurus 23 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046245&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10316804 103977067 CHEMBL349615 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059481 Nc1nc2c(Cc3cccs3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) FJABJEFAQUFECU-UHFFFAOYSA-N 50046242 2-Amino-7-thiophen-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL351815 Purine nucleoside phosphorylase Bos taurus 150 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046242&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10083264 103977064 CHEMBL351815 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059482 Nc1nc2c(Cc3ccc(O)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-1-3-9(18)4-2-7/h1-4,6,15,18H,5H2,(H3,14,16,17,19) PZTAPFWQMIZJNG-UHFFFAOYSA-N 50046220 2-Amino-7-(4-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81731 Purine nucleoside phosphorylase Bos taurus 260 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046220&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10106443 103977042 CHEMBL81731 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059483 Nc1nc2c(Cc3ccsc3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16) QDPMHXUWMPNTEQ-UHFFFAOYSA-N 50039544 2-Amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79784 Purine nucleoside phosphorylase Bos taurus 80 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039544&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 3035609 103946742 CHEMBL79784 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059484 Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3H,4H2,(H2,12,13)(H3,11,14,15,17) HANOSGYMKMNFON-UHFFFAOYSA-N 50005795 CHEMBL285627::PD-119229-2::2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one Purine nucleoside phosphorylase Bos taurus 160 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005795&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 147062 103919220 CHEMBL285627 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059485 Nc1nc2C(Cc3ccccc3)CNc2c(=O)[nH]1 InChI=1S/C13H14N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,9,15H,6-7H2,(H3,14,16,17,18) SRZKQXMAAAAYDI-UHFFFAOYSA-N 50046234 2-Amino-7-benzyl-3,4a,5,7a-tetrahydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL161609 Purine nucleoside phosphorylase Bos taurus 12 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046234 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046234&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929343 103977056 CHEMBL161609 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059486 Nc1nc2c(Cc3ccccc3O)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-3-1-2-4-9(7)18/h1-4,6,15,18H,5H2,(H3,14,16,17,19) RQCPZIFPORZYES-UHFFFAOYSA-N 50046237 2-Amino-7-(2-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL309679 Purine nucleoside phosphorylase Bos taurus 270 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046237 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046237&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11777160 103977059 CHEMBL309679 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50059487 Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,7,15H,6H2,(H3,14,16,17,18) ZBEJFMQAPZKPCM-UHFFFAOYSA-N 50039547 2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL310202 Purine nucleoside phosphorylase Bos taurus 210 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039547&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9881238 103946744 CHEMBL310202 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074807 NC1Nc2c(nc(N)[nH]c2=O)N1Cc1cccs1 InChI=1S/C10H12N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3,10,13H,4,12H2,(H3,11,14,15,17) QBNDMLFHVRRQSV-UHFFFAOYSA-N 50046215 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL162255 Purine nucleoside phosphorylase Bos taurus 0.160000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046215&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374597 103977037 CHEMBL162255 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074808 Nc1nc2cc(NCc3ccco3)[nH]c2c(=O)[nH]1 InChI=1S/C11H11N5O2/c12-11-14-7-4-8(15-9(7)10(17)16-11)13-5-6-2-1-3-18-6/h1-4,13,15H,5H2,(H3,12,14,16,17) ZGYLCKDEKZLMCG-UHFFFAOYSA-N 50046216 2-Amino-6-[(furan-2-ylmethyl)-amino]-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159515 Purine nucleoside phosphorylase Homo sapiens 0.750000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046216&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 54546605 103977038 CHEMBL159515 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074810 Nc1nc2nc(Cc3ccccc3)[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-10-9(11(18)17-12)14-8(15-10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,13,14,15,16,17,18) OILIJBCQSLTTMU-UHFFFAOYSA-N 50046217 2-Amino-8-benzyl-1,9-dihydro-purin-6-one::CHEMBL161692 Purine nucleoside phosphorylase Homo sapiens 30 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046217&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 146473 103977039 CHEMBL161692 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074811 Cc1ccsc1CNc1cc2nc(N)[nH]c(=O)c2[nH]1 InChI=1S/C12H13N5OS/c1-6-2-3-19-8(6)5-14-9-4-7-10(16-9)11(18)17-12(13)15-7/h2-4,14,16H,5H2,1H3,(H3,13,15,17,18) SMMAZKLDCATMSU-UHFFFAOYSA-N 50046218 2-Amino-6-[(3-methyl-thiophen-2-ylmethyl)-amino]-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL348923 Purine nucleoside phosphorylase Homo sapiens 4.1 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046218&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 54313429 103977040 CHEMBL348923 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074813 Nc1nc2cc(NCc3ccsc3)[nH]c2c(=O)[nH]1 InChI=1S/C11H11N5OS/c12-11-14-7-3-8(15-9(7)10(17)16-11)13-4-6-1-2-18-5-6/h1-3,5,13,15H,4H2,(H3,12,14,16,17) MPQOPQYRYDSFJF-UHFFFAOYSA-N 50046221 2-Amino-6-[(thiophen-3-ylmethyl)-amino]-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159316 Purine nucleoside phosphorylase Homo sapiens 0.630000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046221 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046221&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 54084754 103977043 CHEMBL159316 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074816 Nc1nc2cc(NCc3ccccc3)[nH]c2c(=O)[nH]1 InChI=1S/C13H13N5O/c14-13-16-9-6-10(17-11(9)12(19)18-13)15-7-8-4-2-1-3-5-8/h1-6,15,17H,7H2,(H3,14,16,18,19) YISSKQSUWSJOGY-UHFFFAOYSA-N 50046223 2-Amino-6-benzylamino-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL345473 Purine nucleoside phosphorylase Homo sapiens 0.850000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046223&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 54510460 103977045 CHEMBL345473 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074817 Nc1nc2nc(NCc3ccsc3)[nH]c2c(=O)[nH]1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)16-9)13-10(15-7)12-3-5-1-2-18-4-5/h1-2,4H,3H2,(H5,11,12,13,14,15,16,17) NIMWAWRWRANFPU-UHFFFAOYSA-N 50046224 2-Amino-8-[(thiophen-3-ylmethyl)-amino]-1,9-dihydro-purin-6-one::CHEMBL422712 Purine nucleoside phosphorylase Homo sapiens 0.085000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046224&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374662 103977046 CHEMBL422712 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074818 Nc1nc2c(Cc3ccccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-4-2-1-3-7(9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UJAUASVSBLUQKK-UHFFFAOYSA-N 50046253 2-Amino-7-(2-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81966 Purine nucleoside phosphorylase Bos taurus 120 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046253&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10333581 103977075 CHEMBL81966 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074819 NC1Nc2c(nc(N)[nH]c2=O)N1Cc1cccs1 InChI=1S/C10H12N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3,10,13H,4,12H2,(H3,11,14,15,17) QBNDMLFHVRRQSV-UHFFFAOYSA-N 50046215 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL162255 Purine nucleoside phosphorylase Bos taurus 90 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046215&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374597 103977037 CHEMBL162255 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074821 Nc1nc2cc(Cc3cccs3)[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-5-6(4-7-2-1-3-17-7)13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) GNSUOSRTLBMYEA-UHFFFAOYSA-N 50046227 2-Amino-6-thiophen-2-ylmethyl-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL349855 Purine nucleoside phosphorylase Homo sapiens 0.030000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046227 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046227&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929341 103977049 CHEMBL349855 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074822 Nc1nc2cc([nH]c2c(=O)[nH]1)-c1cccnc1 InChI=1S/C11H9N5O/c12-11-15-8-4-7(6-2-1-3-13-5-6)14-9(8)10(17)16-11/h1-5,14H,(H3,12,15,16,17) GUCIPAXWIAOMKH-UHFFFAOYSA-N 50046229 2-Amino-6-pyridin-3-yl-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL352454 Purine nucleoside phosphorylase Bos taurus 0.160000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046229&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 53857398 103977051 CHEMBL352454 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074823 Nc1nc2nc(Cc3ccco3)[nH]c2c(=O)[nH]1 InChI=1S/C10H9N5O2/c11-10-14-8-7(9(16)15-10)12-6(13-8)4-5-2-1-3-17-5/h1-3H,4H2,(H4,11,12,13,14,15,16) QWMAETSCDIEUHQ-UHFFFAOYSA-N 50046230 2-Amino-8-furan-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159555 Purine nucleoside phosphorylase Homo sapiens 18 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046230 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046230&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 18695288 103977052 CHEMBL159555 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074824 Nc1nc2cc(Cc3ccco3)[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4O2/c12-11-14-8-5-6(4-7-2-1-3-17-7)13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) VELRMUOWDSJNFA-UHFFFAOYSA-N 50046231 2-Amino-6-furan-2-ylmethyl-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL349024 Purine nucleoside phosphorylase Homo sapiens 0.057000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046231 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046231&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929342 103977053 CHEMBL349024 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074825 Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h1-3,5-6,15H,4H2,(H3,13,16,17,18) DOHVAKFYAHLCJP-UHFFFAOYSA-N 50039542 2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL311300 Purine nucleoside phosphorylase Bos taurus 190 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039542&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 60817 103946740 CHEMBL311300 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074826 Nc1nc2c(Cc3cccnc3)c[nH]c2c(=O)[nH]1 InChI=1S/C12H11N5O/c13-12-16-9-8(4-7-2-1-3-14-5-7)6-15-10(9)11(18)17-12/h1-3,5-6,15H,4H2,(H3,13,16,17,18) DOHVAKFYAHLCJP-UHFFFAOYSA-N 50039542 2-amino-7-(pyridin-3-ylmethyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(pyridin-3-ylmethyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::2-Amino-7-pyridin-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL311300 Purine nucleoside phosphorylase Bos taurus 25 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039542&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 60817 103946740 CHEMBL311300 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074827 Nc1nc2c(Cc3ccc(Cl)c(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H10Cl2N4O/c14-8-2-1-6(4-9(8)15)3-7-5-17-11-10(7)18-13(16)19-12(11)20/h1-2,4-5,17H,3H2,(H3,16,18,19,20) FVPGRDMKNFHMAJ-UHFFFAOYSA-N 50046225 2-Amino-7-(3,4-dichloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL160043 Purine nucleoside phosphorylase Bos taurus 250 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046225&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10063910 103977047 CHEMBL160043 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074828 Nc1nc2c(Cc3ccsc3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-7(3-6-1-2-17-5-6)4-13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16) QDPMHXUWMPNTEQ-UHFFFAOYSA-N 50039544 2-Amino-7-thiophen-3-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL79784 Purine nucleoside phosphorylase Bos taurus 25 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039544&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 3035609 103946742 CHEMBL79784 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074832 Nc1nc2c(Cc3cc(Cl)cc(Cl)c3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H9Cl3N4O/c14-7-2-5(9(16)8(15)3-7)1-6-4-18-11-10(6)19-13(17)20-12(11)21/h2-4,18H,1H2,(H3,17,19,20,21) RZCKSKZVJBTDGA-UHFFFAOYSA-N 50046228 2-Amino-7-(2,3,5-trichloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL158599 Purine nucleoside phosphorylase Bos taurus 240 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046228 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046228&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11725010 103977050 CHEMBL158599 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074834 Nc1nc2nc(Cc3cccs3)[nH]c2c(=O)[nH]1 InChI=1S/C10H9N5OS/c11-10-14-8-7(9(16)15-10)12-6(13-8)4-5-2-1-3-17-5/h1-3H,4H2,(H4,11,12,13,14,15,16) QSCAOACNBNXUPQ-UHFFFAOYSA-N 50046236 2-Amino-8-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159889 Purine nucleoside phosphorylase Homo sapiens 11 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046236 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046236&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 18695293 103977058 CHEMBL159889 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074836 Cc1ccsc1Cc1nc2nc(N)[nH]c(=O)c2[nH]1 InChI=1S/C11H11N5OS/c1-5-2-3-18-6(5)4-7-13-8-9(14-7)15-11(12)16-10(8)17/h2-3H,4H2,1H3,(H4,12,13,14,15,16,17) JFWJTYDTJFECLW-UHFFFAOYSA-N 50046235 2-Amino-8-(3-methyl-thiophen-2-ylmethyl)-1,9-dihydro-purin-6-one::CHEMBL159556 Purine nucleoside phosphorylase Homo sapiens 48 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046235&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 18799242 103977057 CHEMBL159556 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074837 Nc1nc2c(Cc3ccccc3O)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O2/c14-13-16-10-8(6-15-11(10)12(19)17-13)5-7-3-1-2-4-9(7)18/h1-4,6,15,18H,5H2,(H3,14,16,17,19) RQCPZIFPORZYES-UHFFFAOYSA-N 50046237 2-Amino-7-(2-hydroxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL309679 Purine nucleoside phosphorylase Bos taurus 2000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046237 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046237&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11777160 103977059 CHEMBL309679 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074839 Nc1nc2c(Cc3cc(Cl)cc(Cl)c3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H9Cl3N4O/c14-7-2-5(9(16)8(15)3-7)1-6-4-18-11-10(6)19-13(17)20-12(11)21/h2-4,18H,1H2,(H3,17,19,20,21) RZCKSKZVJBTDGA-UHFFFAOYSA-N 50046228 2-Amino-7-(2,3,5-trichloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL158599 Purine nucleoside phosphorylase Bos taurus 10000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046228 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046228&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11725010 103977050 CHEMBL158599 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074841 NC1Nc2c(nc(N)[nH]c2=O)C1Cc1ccsc1 InChI=1S/C11H13N5OS/c12-9-6(3-5-1-2-18-4-5)7-8(14-9)10(17)16-11(13)15-7/h1-2,4,6,9,14H,3,12H2,(H3,13,15,16,17) XGAPPXKWFKSYLM-UHFFFAOYSA-N 50046238 2,8-Diamino-9-thiophen-3-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159758 Purine nucleoside phosphorylase Bos taurus 0.630000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046238 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046238&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929344 103977060 CHEMBL159758 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074843 Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) CULKYGOMWFATON-UHFFFAOYSA-N 50042804 2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(3-chlorobenzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310364 Purine nucleoside phosphorylase Bos taurus 150 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042804&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778127 103974369 CHEMBL310364 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074844 Nc1nc2c(nc(N)[nH]c2=O)n1Cc1cccs1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3H,4H2,(H2,12,13)(H3,11,14,15,17) HANOSGYMKMNFON-UHFFFAOYSA-N 50005795 CHEMBL285627::PD-119229-2::2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one Purine nucleoside phosphorylase Bos taurus 160 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50005795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50005795&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 147062 103919220 CHEMBL285627 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074845 Nc1nc2nc(NCc3ccco3)[nH]c2c(=O)[nH]1 InChI=1S/C10H10N6O2/c11-9-14-7-6(8(17)16-9)13-10(15-7)12-4-5-2-1-3-18-5/h1-3H,4H2,(H5,11,12,13,14,15,16,17) XUPAYBISZXCGPW-UHFFFAOYSA-N 50046241 2-Amino-8-[(furan-2-ylmethyl)-amino]-1,9-dihydro-purin-6-one::CHEMBL351219 Purine nucleoside phosphorylase Homo sapiens 0.250000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046241&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374435 103977063 CHEMBL351219 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074847 Nc1nc2c(Cc3ccccc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O/c14-13-16-10-9(6-8-4-2-1-3-5-8)7-15-11(10)12(18)17-13/h1-5,7,15H,6H2,(H3,14,16,17,18) ZBEJFMQAPZKPCM-UHFFFAOYSA-N 50039547 2-amino-7-benzyl-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::2-Amino-7-benzyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL310202 Purine nucleoside phosphorylase Bos taurus 51 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50039547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50039547&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 9881238 103946744 CHEMBL310202 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074849 Nc1nc2cc(NCc3cccs3)[nH]c2c(=O)[nH]1 InChI=1S/C11H11N5OS/c12-11-14-7-4-8(15-9(7)10(17)16-11)13-5-6-2-1-3-18-6/h1-4,13,15H,5H2,(H3,12,14,16,17) VSNKCKXMHPFFRF-UHFFFAOYSA-N 50046243 2-Amino-6-[(thiophen-2-ylmethyl)-amino]-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159514 Purine nucleoside phosphorylase Homo sapiens 1 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046243&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 54408624 103977065 CHEMBL159514 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074852 Nc1nc2nc(NCc3cccs3)[nH]c2c(=O)[nH]1 InChI=1S/C10H10N6OS/c11-9-14-7-6(8(17)16-9)13-10(15-7)12-4-5-2-1-3-18-5/h1-3H,4H2,(H5,11,12,13,14,15,16,17) ASPRVQARSFBOHF-UHFFFAOYSA-N 50046246 2-Amino-8-[(thiophen-2-ylmethyl)-amino]-1,9-dihydro-purin-6-one::CHEMBL351228 Purine nucleoside phosphorylase Homo sapiens 0.160000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046246&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374663 103977068 CHEMBL351228 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074853 Cc1cccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)c1 InChI=1S/C14H14N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h2-5,7,16H,6H2,1H3,(H3,15,17,18,19) ICFRYSRRTZTEHG-UHFFFAOYSA-N 50046222 2-Amino-7-(3-methyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159960 Purine nucleoside phosphorylase Bos taurus 57 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046222&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10060867 103977044 CHEMBL159960 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074854 NC1Nc2c(nc(N)[nH]c2=O)N1Cc1cccs1 InChI=1S/C10H12N6OS/c11-9-14-7-6(8(17)15-9)13-10(12)16(7)4-5-2-1-3-18-5/h1-3,10,13H,4,12H2,(H3,11,14,15,17) QBNDMLFHVRRQSV-UHFFFAOYSA-N 50046215 2,8-Diamino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL162255 Purine nucleoside phosphorylase Bos taurus 45 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046215&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374597 103977037 CHEMBL162255 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074855 Cc1ccsc1CNc1nc2nc(N)[nH]c(=O)c2[nH]1 InChI=1S/C11H12N6OS/c1-5-2-3-19-6(5)4-13-11-14-7-8(16-11)15-10(12)17-9(7)18/h2-3H,4H2,1H3,(H5,12,13,14,15,16,17,18) VZJBSOZNPAOAMB-UHFFFAOYSA-N 50046248 2-Amino-8-[(3-methyl-thiophen-2-ylmethyl)-amino]-1,9-dihydro-purin-6-one::CHEMBL350773 Purine nucleoside phosphorylase Homo sapiens 4.1 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046248 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046248&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374591 103977070 CHEMBL350773 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074856 Nc1nc2nc([nH]c2c(=O)[nH]1)-c1cccnc1 InChI=1S/C10H8N6O/c11-10-15-8-6(9(17)16-10)13-7(14-8)5-2-1-3-12-4-5/h1-4H,(H4,11,13,14,15,16,17) CYNGEGTWGBHJBB-UHFFFAOYSA-N 50046247 2-Amino-8-pyridin-3-yl-1,9-dihydro-purin-6-one::CHEMBL350559 Purine nucleoside phosphorylase Homo sapiens 57 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046247&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11299129 103977069 CHEMBL350559 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074857 COc1cccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)c1 InChI=1S/C14H14N4O2/c1-20-10-4-2-3-8(6-10)5-9-7-16-12-11(9)17-14(15)18-13(12)19/h2-4,6-7,16H,5H2,1H3,(H3,15,17,18,19) DOQAZHCUONJLMW-UHFFFAOYSA-N 50046214 2-Amino-7-(3-methoxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL162751 Purine nucleoside phosphorylase Bos taurus 660 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046214&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10400926 103977036 CHEMBL162751 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074858 Nc1nc2c(Cc3cccc(F)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11FN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) WOWBUNTUMYSYSI-UHFFFAOYSA-N 50046233 2-Amino-7-(3-fluoro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159908 Purine nucleoside phosphorylase Bos taurus 24 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046233 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046233&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10061045 103977055 CHEMBL159908 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074860 Nc1nc2c(Cc3cccc(Oc4ccccc4)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C19H16N4O2/c20-19-22-16-13(11-21-17(16)18(24)23-19)9-12-5-4-8-15(10-12)25-14-6-2-1-3-7-14/h1-8,10-11,21H,9H2,(H3,20,22,23,24) SZLVNGWVKLCDQQ-UHFFFAOYSA-N 50046244 2-Amino-7-(3-phenoxy-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159471 Purine nucleoside phosphorylase Bos taurus 740 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046244&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374526 103977066 CHEMBL159471 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074861 Nc1nc2c(Cc3cccs3)c[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-6(4-7-2-1-3-17-7)5-13-9(8)10(16)15-11/h1-3,5,13H,4H2,(H3,12,14,15,16) FJABJEFAQUFECU-UHFFFAOYSA-N 50046242 2-Amino-7-thiophen-2-ylmethyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL351815 Purine nucleoside phosphorylase Bos taurus 21 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046242&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10083264 103977064 CHEMBL351815 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074862 Nc1nc2nc(NCc3ccccc3)[nH]c2c(=O)[nH]1 InChI=1S/C12H12N6O/c13-11-16-9-8(10(19)18-11)15-12(17-9)14-6-7-4-2-1-3-5-7/h1-5H,6H2,(H5,13,14,15,16,17,18,19) QWCQVGUXEGLGMP-UHFFFAOYSA-N 50046251 2-Amino-8-benzylamino-1,9-dihydro-purin-6-one::CHEMBL350429 Purine nucleoside phosphorylase Homo sapiens 0.470000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046251 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046251&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374433 103977073 CHEMBL350429 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074863 Nc1nc2c(Cc3ccc(I)cc3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11IN4O/c14-9-3-1-7(2-4-9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) GFFQSWANLMANPJ-UHFFFAOYSA-N 50046245 2-Amino-7-(4-iodo-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL349615 Purine nucleoside phosphorylase Bos taurus 270 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046245&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10316804 103977067 CHEMBL349615 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074864 Nc1nc2cc(Cc3ccsc3)[nH]c2c(=O)[nH]1 InChI=1S/C11H10N4OS/c12-11-14-8-4-7(3-6-1-2-17-5-6)13-9(8)10(16)15-11/h1-2,4-5,13H,3H2,(H3,12,14,15,16) QEWHDRALIAZAFN-UHFFFAOYSA-N 50046249 2-Amino-6-thiophen-3-ylmethyl-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159271 Purine nucleoside phosphorylase Homo sapiens 0.067000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046249&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 91929346 103977071 CHEMBL159271 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074866 Nc1nc2c(Cc3ccccc3Cl)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-4-2-1-3-7(9)5-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-4,6,16H,5H2,(H3,15,17,18,19) UJAUASVSBLUQKK-UHFFFAOYSA-N 50046253 2-Amino-7-(2-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL81966 Purine nucleoside phosphorylase Bos taurus 2520 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046253&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10333581 103977075 CHEMBL81966 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074869 Nc1nc2c(Cc3cccc(Cl)c3)c[nH]c2c(=O)[nH]1 InChI=1S/C13H11ClN4O/c14-9-3-1-2-7(5-9)4-8-6-16-11-10(8)17-13(15)18-12(11)19/h1-3,5-6,16H,4H2,(H3,15,17,18,19) CULKYGOMWFATON-UHFFFAOYSA-N 50042804 2-Amino-7-(3-chloro-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::2-amino-7-(3-chlorobenzyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one::CHEMBL310364 Purine nucleoside phosphorylase Bos taurus 20 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50042804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50042804&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 11778127 103974369 CHEMBL310364 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074870 Cc1ccsc1Cc1cc2nc(N)[nH]c(=O)c2[nH]1 InChI=1S/C12H12N4OS/c1-6-2-3-18-9(6)5-7-4-8-10(14-7)11(17)16-12(13)15-8/h2-4,14H,5H2,1H3,(H3,13,15,16,17) CCFUNILMNYXTIZ-UHFFFAOYSA-N 50046250 2-Amino-6-(3-methyl-thiophen-2-ylmethyl)-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159409 Purine nucleoside phosphorylase Homo sapiens 48 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046250 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046250&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 53713674 103977072 CHEMBL159409 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074871 Cc1cccc(Cc2c[nH]c3c2nc(N)[nH]c3=O)c1 InChI=1S/C14H14N4O/c1-8-3-2-4-9(5-8)6-10-7-16-12-11(10)17-14(15)18-13(12)19/h2-5,7,16H,6H2,1H3,(H3,15,17,18,19) ICFRYSRRTZTEHG-UHFFFAOYSA-N 50046222 2-Amino-7-(3-methyl-benzyl)-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159960 Purine nucleoside phosphorylase Bos taurus 270 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046222&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 10060867 103977044 CHEMBL159960 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074874 Nc1nc2N(Cc3cccs3)CNc2c(=O)[nH]1 InChI=1S/C10H11N5OS/c11-10-13-8-7(9(16)14-10)12-5-15(8)4-6-2-1-3-17-6/h1-3,12H,4-5H2,(H3,11,13,14,16) UPNZQUYQZWHTQQ-UHFFFAOYSA-N 50046226 2-Amino-9-thiophen-2-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL345655 Purine nucleoside phosphorylase Bos taurus 11 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2243&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046226&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374593 103977048 CHEMBL345655 1 MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPESTVPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGLNPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQMGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG 2QPL Purine nucleoside phosphorylase PNPH_BOVIN P55859 Q3ZBH6 Q58DQ2 50074875 Nc1nc2nc(Cc3ccsc3)[nH]c2c(=O)[nH]1 InChI=1S/C10H9N5OS/c11-10-14-8-7(9(16)15-10)12-6(13-8)3-5-1-2-17-4-5/h1-2,4H,3H2,(H4,11,12,13,14,15,16) NSMPJAYXYKAEJY-UHFFFAOYSA-N 50046254 2-Amino-8-thiophen-3-ylmethyl-1,9-dihydro-purin-6-one::CHEMBL159525 Purine nucleoside phosphorylase Homo sapiens 11 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046254 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046254&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 18695239 103977076 CHEMBL159525 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074876 Nc1nc2nc(Nc3cccnc3)[nH]c2c(=O)[nH]1 InChI=1S/C10H9N7O/c11-9-15-7-6(8(18)17-9)14-10(16-7)13-5-2-1-3-12-4-5/h1-4H,(H5,11,13,14,15,16,17,18) AZRLNXMWWUPIGP-UHFFFAOYSA-N 50046255 2-Amino-8-(pyridin-3-ylamino)-1,9-dihydro-purin-6-one::CHEMBL159266 Purine nucleoside phosphorylase Homo sapiens 22 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046255&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 44374463 103977077 CHEMBL159266 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03 50074877 Nc1nc2cc(Cc3ccccc3)[nH]c2c(=O)[nH]1 InChI=1S/C13H12N4O/c14-13-16-10-7-9(15-11(10)12(18)17-13)6-8-4-2-1-3-5-8/h1-5,7,15H,6H2,(H3,14,16,17,18) ABDGHNXKFPUDCD-UHFFFAOYSA-N 50046252 2-Amino-6-benzyl-3,7-dihydro-pyrrolo[3,2-d]pyrimidin-4-one::CHEMBL159747 Purine nucleoside phosphorylase Homo sapiens 0.085000 ChEMBL 10.1021/jm00053a008 10.7270/Q2B27TCX 8421291 Montgomery, JA; Niwas, S; Rose, JD; Secrist, JA; Babu, YS; Bugg, CE; Erion, MD; Guida, WC; Ealick, SE 2/16/1993 11/10/2009 Biocryst Pharmaceuticals http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50046252 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2242&target=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50046252&enzyme=Purine+nucleoside+phosphorylase&column=ki&startPg=0&Increment=50&submit=Search 53633557 103977074 CHEMBL159747 1 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS 7ZSP,7ZSO,7ZSN,7ZSM,7ZSL Purine nucleoside phosphorylase PNPH_HUMAN P00491 B2R8S5 D3DS00 Q15160 Q5PZ03