BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 50080529 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccccc1Cl InChI=1S/C15H15ClN6/c1-22(12-5-3-2-4-10(12)16)8-9-6-7-11-13(19-9)14(17)21-15(18)20-11/h2-7H,8H2,1H3,(H4,17,18,20,21) GZLIYLWITBUHLE-UHFFFAOYSA-N 50049576 6-{[(2-Chloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53318 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 210 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049576&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462108 103979888 CHEMBL53318 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080530 COc1cccc(NCc2ccc3nc(N)nc(N)c3n2)c1 InChI=1S/C15H16N6O/c1-22-11-4-2-3-9(7-11)18-8-10-5-6-12-13(19-10)14(16)21-15(17)20-12/h2-7,18H,8H2,1H3,(H4,16,17,20,21) VUDSXUWVNZOREL-UHFFFAOYSA-N 50049577 6-[(3-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52836 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 100 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049577&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457748 103979889 CHEMBL52836 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080531 Nc1nc(N)c2nc(CNc3ccc(Cl)cc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-7-1-3-10(9(16)5-7)19-6-8-2-4-11-12(20-8)13(17)22-14(18)21-11/h1-5,19H,6H2,(H4,17,18,21,22) DMNKLTYJZVLTIU-UHFFFAOYSA-N 50049578 6-[(2,4-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292634 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 50 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049578&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 466051 103979890 CHEMBL292634 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080532 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cc(Cl)ccc1Cl InChI=1S/C15H14Cl2N6/c1-23(12-6-8(16)2-4-10(12)17)7-9-3-5-11-13(20-9)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) MLHOJOGIBNGAAO-UHFFFAOYSA-N 50049579 6-{[(2,5-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55191 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 25 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049579&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462107 103979891 CHEMBL55191 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080533 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cccc(Cl)c1 InChI=1S/C15H15ClN6/c1-22(11-4-2-3-9(16)7-11)8-10-5-6-12-13(19-10)14(17)21-15(18)20-12/h2-7H,8H2,1H3,(H4,17,18,20,21) YGMFWJRAPSYNFQ-UHFFFAOYSA-N 50031866 6-(((3-chlorophenyl)(methyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(3-Chloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54399 Dihydrofolate reductase Rattus norvegicus 67 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031866&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 464891 103940428 CHEMBL54399 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080534 CC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1 InChI=1S/C16H16N6O/c1-9(23)10-2-4-11(5-3-10)19-8-12-6-7-13-14(20-12)15(17)22-16(18)21-13/h2-7,19H,8H2,1H3,(H4,17,18,21,22) OSWHAJUIPNBZGO-UHFFFAOYSA-N 50049575 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-phenyl}-ethanone::CHEMBL301795 Dihydrofolate reductase Rattus norvegicus 2.5 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049575&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457768 103979887 CHEMBL301795 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080535 COc1cc(NCc2ccc3nc(N)nc(N)c3n2)cc(OC)c1OC InChI=1S/C17H20N6O3/c1-24-12-6-10(7-13(25-2)15(12)26-3)20-8-9-4-5-11-14(21-9)16(18)23-17(19)22-11/h4-7,20H,8H2,1-3H3,(H4,18,19,22,23) ASYMVCBDRFSMND-UHFFFAOYSA-N 50031868 6-[(3,4,5-Trimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::6-((3,4,5-trimethoxyphenylamino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55179 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 40 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031868&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457751 103940430 CHEMBL55179 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080536 Nc1nc(N)c2nc(CNc3ccc4ccccc4c3)ccc2n1 InChI=1S/C18H16N6/c19-17-16-15(23-18(20)24-17)8-7-14(22-16)10-21-13-6-5-11-3-1-2-4-12(11)9-13/h1-9,21H,10H2,(H4,19,20,23,24) QZFNYULCWRTRSJ-UHFFFAOYSA-N 50049580 6-(Naphthalen-2-ylaminomethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL417746 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1600 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049580&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457745 103979892 CHEMBL417746 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080537 Nc1nc(N)c2nc(CSc3ccccc3)ccc2n1 InChI=1S/C14H13N5S/c15-13-12-11(18-14(16)19-13)7-6-9(17-12)8-20-10-4-2-1-3-5-10/h1-7H,8H2,(H4,15,16,18,19) DKLBFJLXPKVFCS-UHFFFAOYSA-N 50049581 6-Phenylsulfanylmethyl-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL300886 Dihydrofolate reductase Rattus norvegicus 520 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049581&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466050 103979893 CHEMBL300886 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080538 Nc1nc(N)c2nc(CNc3cccc4ccccc34)ccc2n1 InChI=1S/C18H16N6/c19-17-16-15(23-18(20)24-17)9-8-12(22-16)10-21-14-7-3-5-11-4-1-2-6-13(11)14/h1-9,21H,10H2,(H4,19,20,23,24) UHHPRQVHWBEBHX-UHFFFAOYSA-N 50049582 6-(Naphthalen-1-ylaminomethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL299140 Dihydrofolate reductase Rattus norvegicus 40 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049582&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466054 103979894 CHEMBL299140 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080539 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc2ccccc2c1 InChI=1S/C19H18N6/c1-25(15-8-6-12-4-2-3-5-13(12)10-15)11-14-7-9-16-17(22-14)18(20)24-19(21)23-16/h2-10H,11H2,1H3,(H4,20,21,23,24) XVMYUHGKEGJVTF-UHFFFAOYSA-N 50049583 6-[(Methyl-naphthalen-2-yl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55727 Dihydrofolate reductase Rattus norvegicus 7.2 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049583&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462099 103979895 CHEMBL55727 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080540 Nc1nc(N)c2nc(CNc3ccc4ccccc4c3)ccc2n1 InChI=1S/C18H16N6/c19-17-16-15(23-18(20)24-17)8-7-14(22-16)10-21-13-6-5-11-3-1-2-4-12(11)9-13/h1-9,21H,10H2,(H4,19,20,23,24) QZFNYULCWRTRSJ-UHFFFAOYSA-N 50049580 6-(Naphthalen-2-ylaminomethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL417746 Dihydrofolate reductase Rattus norvegicus 210 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049580&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457745 103979892 CHEMBL417746 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080541 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1 InChI=1S/C15H16N6O/c1-22-11-5-2-9(3-6-11)18-8-10-4-7-12-13(19-10)14(16)21-15(17)20-12/h2-7,18H,8H2,1H3,(H4,16,17,20,21) FFOCJHIGLIUZJX-UHFFFAOYSA-N 50049584 6-[(4-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52777 Dihydrofolate reductase Rattus norvegicus 73.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049584&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457776 103979896 CHEMBL52777 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080542 CN(Cc1ccc2nc(N)nc(N)c2n1)c1c(Cl)cccc1Cl InChI=1S/C15H14Cl2N6/c1-23(13-9(16)3-2-4-10(13)17)7-8-5-6-11-12(20-8)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) DNNXTJQYLQSKHE-UHFFFAOYSA-N 50049586 6-{[(2,6-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL445359 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 170 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049586&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462109 103979898 CHEMBL445359 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080543 Nc1nc(N)c2nc(CNc3cc(Cl)c(Cl)c(Cl)c3)ccc2n1 InChI=1S/C14H11Cl3N6/c15-8-3-7(4-9(16)11(8)17)20-5-6-1-2-10-12(21-6)13(18)23-14(19)22-10/h1-4,20H,5H2,(H4,18,19,22,23) JBJCNGDWWRTSBU-UHFFFAOYSA-N 50049589 6-[(3,4,5-Trichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53420 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 87.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049589&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457774 103979901 CHEMBL53420 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080544 Nc1nc(N)c2nc(CSc3ccccc3)ccc2n1 InChI=1S/C14H13N5S/c15-13-12-11(18-14(16)19-13)7-6-9(17-12)8-20-10-4-2-1-3-5-10/h1-7H,8H2,(H4,15,16,18,19) DKLBFJLXPKVFCS-UHFFFAOYSA-N 50049581 6-Phenylsulfanylmethyl-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL300886 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 2000 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049581&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466050 103979893 CHEMBL300886 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080545 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(cc1)C(C)=O InChI=1S/C17H18N6O/c1-10(24)11-3-6-13(7-4-11)23(2)9-12-5-8-14-15(20-12)16(18)22-17(19)21-14/h3-8H,9H2,1-2H3,(H4,18,19,21,22) GATWXZCVAPEINN-UHFFFAOYSA-N 50049587 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-phenyl}-ethanone::CHEMBL55012 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 130 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049587&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457769 103979899 CHEMBL55012 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080546 Nc1nc(N)c2nc(CN(CC#C)c3ccc(cc3)C(=O)C(F)(F)F)ccc2n1 InChI=1S/C19H15F3N6O/c1-2-9-28(13-6-3-11(4-7-13)16(29)19(20,21)22)10-12-5-8-14-15(25-12)17(23)27-18(24)26-14/h1,3-8H,9-10H2,(H4,23,24,26,27) ZPVABTSOZGBWAC-UHFFFAOYSA-N 50049585 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-2,2,2-trifluoro-ethanone::CHEMBL53872 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 54.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049585&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457772 103979897 CHEMBL53872 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080547 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1 InChI=1S/C15H16N6O/c1-22-11-5-2-9(3-6-11)18-8-10-4-7-12-13(19-10)14(16)21-15(17)20-12/h2-7,18H,8H2,1H3,(H4,16,17,20,21) FFOCJHIGLIUZJX-UHFFFAOYSA-N 50049584 6-[(4-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52777 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 850.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049584&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457776 103979896 CHEMBL52777 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080548 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cc(Cl)c(Cl)c(Cl)c1 InChI=1S/C15H13Cl3N6/c1-24(8-4-9(16)12(18)10(17)5-8)6-7-2-3-11-13(21-7)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23) FVRDUZOKYWZFLL-UHFFFAOYSA-N 50049588 6-{[Methyl-(3,4,5-trichloro-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52698 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 250 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049588&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462104 103979900 CHEMBL52698 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080549 Nc1nc(N)c2nc(CN(CC#C)c3ccc(cc3)C(=O)C(F)(F)F)ccc2n1 InChI=1S/C19H15F3N6O/c1-2-9-28(13-6-3-11(4-7-13)16(29)19(20,21)22)10-12-5-8-14-15(25-12)17(23)27-18(24)26-14/h1,3-8H,9-10H2,(H4,23,24,26,27) ZPVABTSOZGBWAC-UHFFFAOYSA-N 50049585 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-2,2,2-trifluoro-ethanone::CHEMBL53872 Dihydrofolate reductase Rattus norvegicus 7.5 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049585&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457772 103979897 CHEMBL53872 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080550 Nc1nc(N)c2nc(CNc3ccc4ccccc4c3)ccc2n1 InChI=1S/C18H16N6/c19-17-16-15(23-18(20)24-17)8-7-14(22-16)10-21-13-6-5-11-3-1-2-4-12(11)9-13/h1-9,21H,10H2,(H4,19,20,23,24) QZFNYULCWRTRSJ-UHFFFAOYSA-N 50049580 6-(Naphthalen-2-ylaminomethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL417746 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 160 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049580&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457745 103979892 CHEMBL417746 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080551 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)C(F)(F)F InChI=1S/C17H15F3N6O/c1-26(11-5-2-9(3-6-11)14(27)17(18,19)20)8-10-4-7-12-13(23-10)15(21)25-16(22)24-12/h2-7H,8H2,1H3,(H4,21,22,24,25) ZFUKPZOQUMPCIJ-UHFFFAOYSA-N 50049590 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-phenyl}-2,2,2-trifluoro-ethanone::CHEMBL55049 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 250 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049590&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457771 103979902 CHEMBL55049 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080552 CN(Cc1ccc2nc(N)nc(N)c2n1)c1c(Cl)cc(Cl)cc1Cl InChI=1S/C15H13Cl3N6/c1-24(13-9(17)4-7(16)5-10(13)18)6-8-2-3-11-12(21-8)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23) RQTLSQCDNIJYOU-UHFFFAOYSA-N 50049591 6-{[Methyl-(2,4,6-trichloro-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52930 Dihydrofolate reductase Rattus norvegicus 52.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049591&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462110 103979903 CHEMBL52930 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080553 Nc1nc(N)c2nc(CNc3cc(Cl)ccc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-7-1-3-9(16)11(5-7)19-6-8-2-4-10-12(20-8)13(17)22-14(18)21-10/h1-5,19H,6H2,(H4,17,18,21,22) NIOYPZTZXRUMAN-UHFFFAOYSA-N 50049592 6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292212 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 91 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049592&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462106 103979904 CHEMBL292212 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080554 CC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1 InChI=1S/C16H16N6O/c1-9(23)10-2-4-11(5-3-10)19-8-12-6-7-13-14(20-12)15(17)22-16(18)21-13/h2-7,19H,8H2,1H3,(H4,17,18,21,22) OSWHAJUIPNBZGO-UHFFFAOYSA-N 50049575 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-phenyl}-ethanone::CHEMBL301795 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 27 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049575&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457768 103979887 CHEMBL301795 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080555 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cc(Cl)c(Cl)c(Cl)c1 InChI=1S/C15H13Cl3N6/c1-24(8-4-9(16)12(18)10(17)5-8)6-7-2-3-11-13(21-7)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23) FVRDUZOKYWZFLL-UHFFFAOYSA-N 50049588 6-{[Methyl-(3,4,5-trichloro-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52698 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 38 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049588&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462104 103979900 CHEMBL52698 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080556 Nc1nc(N)c2nc(CNc3ccccc3Cl)ccc2n1 InChI=1S/C14H13ClN6/c15-9-3-1-2-4-10(9)18-7-8-5-6-11-12(19-8)13(16)21-14(17)20-11/h1-6,18H,7H2,(H4,16,17,20,21) UXOVXFBHRPRGRY-UHFFFAOYSA-N 50049594 6-[(2-Chloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53165 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 110 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049594&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457750 103979906 CHEMBL53165 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080557 CN(Cc1ccc2nc(N)nc(N)c2n1)c1c(Cl)cccc1Cl InChI=1S/C15H14Cl2N6/c1-23(13-9(16)3-2-4-10(13)17)7-8-5-6-11-12(20-8)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) DNNXTJQYLQSKHE-UHFFFAOYSA-N 50049586 6-{[(2,6-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL445359 Dihydrofolate reductase Rattus norvegicus 48 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049586&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462109 103979898 CHEMBL445359 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080558 Nc1nc(N)c2nc(CNc3ccccc3)ccc2n1 InChI=1S/C14H14N6/c15-13-12-11(19-14(16)20-13)7-6-10(18-12)8-17-9-4-2-1-3-5-9/h1-7,17H,8H2,(H4,15,16,19,20) SHGASZWNAPZHFB-UHFFFAOYSA-N 50049593 6-Phenylaminomethyl-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54733 Dihydrofolate reductase Rattus norvegicus 260 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049593&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457773 103979905 CHEMBL54733 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080559 COc1cc(cc(OC)c1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C18H22N6O3/c1-24(11-7-13(25-2)16(27-4)14(8-11)26-3)9-10-5-6-12-15(21-10)17(19)23-18(20)22-12/h5-8H,9H2,1-4H3,(H4,19,20,22,23) DQLHWXMDFBDATJ-UHFFFAOYSA-N 50031867 6-((methyl(3,4,5-trimethoxyphenyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52688 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 4.7 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031867&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 464889 103940429 CHEMBL52688 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080560 Nc1nc(N)c2nc(CSc3cccc4ccccc34)ccc2n1 InChI=1S/C18H15N5S/c19-17-16-14(22-18(20)23-17)9-8-12(21-16)10-24-15-7-3-5-11-4-1-2-6-13(11)15/h1-9H,10H2,(H4,19,20,22,23) KUKKYMVHCDIMNT-UHFFFAOYSA-N 50049595 6-(Naphthalen-1-ylsulfanylmethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55656 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 49 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049595&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 466052 103979907 CHEMBL55656 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080561 COc1ccc(OC)c(NCc2ccc3nc(N)nc(N)c3n2)c1 InChI=1S/C16H18N6O2/c1-23-10-4-6-13(24-2)12(7-10)19-8-9-3-5-11-14(20-9)15(17)22-16(18)21-11/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) PIKOPKOXFNIUMO-UHFFFAOYSA-N 50031872 6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::6-((2,5-dimethoxyphenylamino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52947 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 120 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031872&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457778 103940434 CHEMBL52947 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080562 COc1ccc(SCc2cnc3nc(N)nc(N)c3c2C)cc1 InChI=1S/C16H17N5OS/c1-9-10(8-23-12-5-3-11(22-2)4-6-12)7-19-15-13(9)14(17)20-16(18)21-15/h3-7H,8H2,1-2H3,(H4,17,18,19,20,21) YYBYCBOPPNOBID-UHFFFAOYSA-N 50049596 6-(4-Methoxy-phenylsulfanylmethyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL23911 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 560.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049596&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 464984 103979908 CHEMBL23911 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080563 Nc1nc(N)c2nc(CNc3cc(Cl)c(Cl)c(Cl)c3)ccc2n1 InChI=1S/C14H11Cl3N6/c15-8-3-7(4-9(16)11(8)17)20-5-6-1-2-10-12(21-6)13(18)23-14(19)22-10/h1-4,20H,5H2,(H4,18,19,22,23) JBJCNGDWWRTSBU-UHFFFAOYSA-N 50049589 6-[(3,4,5-Trichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53420 Dihydrofolate reductase Rattus norvegicus 44 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049589&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457774 103979901 CHEMBL53420 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080564 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1OC InChI=1S/C16H18N6O2/c1-23-12-6-4-9(7-13(12)24-2)19-8-10-3-5-11-14(20-10)15(17)22-16(18)21-11/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) ONOFLDOKBQQVPB-UHFFFAOYSA-N 50049597 6-[(3,4-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55928 Dihydrofolate reductase Rattus norvegicus 60 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049597&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457746 103979909 CHEMBL55928 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080565 Nc1nc(N)c2nc(CSc3ccc4ccccc4c3)ccc2n1 InChI=1S/C18H15N5S/c19-17-16-15(22-18(20)23-17)8-6-13(21-16)10-24-14-7-5-11-3-1-2-4-12(11)9-14/h1-9H,10H2,(H4,19,20,22,23) KZQPPNIWGDASNT-UHFFFAOYSA-N 50049598 6-(Naphthalen-2-ylsulfanylmethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292143 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 380 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049598&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466053 103979910 CHEMBL292143 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080566 CC(=O)c1ccc(cc1)N(CC#C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C19H18N6O/c1-3-10-25(15-7-4-13(5-8-15)12(2)26)11-14-6-9-16-17(22-14)18(20)24-19(21)23-16/h1,4-9H,10-11H2,2H3,(H4,20,21,23,24) SSWYRLKEHKZJPV-UHFFFAOYSA-N 50049599 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-ethanone::CHEMBL52953 Dihydrofolate reductase Rattus norvegicus 15 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049599&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457770 103979911 CHEMBL52953 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080567 COc1ccc(SCc2cnc3nc(N)nc(N)c3c2C)cc1 InChI=1S/C16H17N5OS/c1-9-10(8-23-12-5-3-11(22-2)4-6-12)7-19-15-13(9)14(17)20-16(18)21-15/h3-7H,8H2,1-2H3,(H4,17,18,19,20,21) YYBYCBOPPNOBID-UHFFFAOYSA-N 50049596 6-(4-Methoxy-phenylsulfanylmethyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL23911 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 63 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049596&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 464984 103979908 CHEMBL23911 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080568 Nc1nc(N)c2nc(CNc3ccc(Cl)c(Cl)c3)ccc2n1 InChI=1S/C14H12Cl2N6/c15-9-3-1-7(5-10(9)16)19-6-8-2-4-11-12(20-8)13(17)22-14(18)21-11/h1-5,19H,6H2,(H4,17,18,21,22) YAMIFIPZNRDIHD-UHFFFAOYSA-N 50049600 6-[(3,4-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292427 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 57.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049600&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457744 103979912 CHEMBL292427 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080569 COc1ccc(cc1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(11-4-6-12(23-2)7-5-11)9-10-3-8-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) BSHIEINVRLJMLH-UHFFFAOYSA-N 50049601 6-{[(4-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL415962 Dihydrofolate reductase Rattus norvegicus 18 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049601 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049601&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457752 103979913 CHEMBL415962 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080570 COc1cc(cc(c1OC)OC)Cc2cnc(nc2N)N InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) IEDVJHCEMCRBQM-UHFFFAOYSA-N 18069 CHEMBL22::TMP::Trimethoprim (TMP)::5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine::Trimethoprim::US10870625, Compound TMP Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 12000 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18069&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search TOP 5578 46518184 CHEMBL22 DB00440 C01965 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080571 COc1cc(NCc2ccc3nc(N)nc(N)c3n2)cc(OC)c1OC InChI=1S/C17H20N6O3/c1-24-12-6-10(7-13(25-2)15(12)26-3)20-8-9-4-5-11-14(21-9)16(18)23-17(19)22-11/h4-7,20H,8H2,1-3H3,(H4,18,19,22,23) ASYMVCBDRFSMND-UHFFFAOYSA-N 50031868 6-[(3,4,5-Trimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::6-((3,4,5-trimethoxyphenylamino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55179 Dihydrofolate reductase Rattus norvegicus 200 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031868&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457751 103940430 CHEMBL55179 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080572 COc1ccc(N(C)Cc2ccc3nc(N)nc(N)c3n2)c(OC)c1 InChI=1S/C17H20N6O2/c1-23(13-7-5-11(24-2)8-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) AVMATARNDBSZRC-UHFFFAOYSA-N 50049603 6-{[(2,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL299174 Dihydrofolate reductase Rattus norvegicus 16 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049603&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462097 103979915 CHEMBL299174 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080573 CN(Cc1ccc2nc(N)nc(N)c2n1)c1c(Cl)cccc1Cl InChI=1S/C15H14Cl2N6/c1-23(13-9(16)3-2-4-10(13)17)7-8-5-6-11-12(20-8)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) DNNXTJQYLQSKHE-UHFFFAOYSA-N 50049586 6-{[(2,6-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL445359 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 30 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049586&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462109 103979898 CHEMBL445359 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080574 Nc1nc(N)c2nc(CSc3ccccc3)cnc2n1 InChI=1S/C13H12N6S/c14-11-10-12(19-13(15)18-11)16-6-8(17-10)7-20-9-4-2-1-3-5-9/h1-6H,7H2,(H4,14,15,16,18,19) ZJOATKLQTCGUSP-UHFFFAOYSA-N 50049602 6-Phenylsulfanylmethyl-pteridine-2,4-diamine::CHEMBL279243 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 770 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049602&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 314604 103979914 CHEMBL279243 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080575 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cccc2ccccc12 InChI=1S/C19H18N6/c1-25(16-8-4-6-12-5-2-3-7-14(12)16)11-13-9-10-15-17(22-13)18(20)24-19(21)23-15/h2-10H,11H2,1H3,(H4,20,21,23,24) YKSUMKODGROPHK-UHFFFAOYSA-N 50049604 6-[(Methyl-naphthalen-1-yl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54538 Dihydrofolate reductase Rattus norvegicus 7.3 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049604&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462100 103979916 CHEMBL54538 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080576 COc1cccc(c1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(11-4-3-5-12(8-11)23-2)9-10-6-7-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) VUOWLRUPFRBDGR-UHFFFAOYSA-N 50049607 6-{[(3-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54792 Dihydrofolate reductase Rattus norvegicus 35 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049607&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462098 103979919 CHEMBL54792 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080577 COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) NOYPYLRCIDNJJB-UHFFFAOYSA-N 18268 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine::TMQ::CHEMBL119::Trimetrexate::US11111252, Compound TMQ::US11530198, Example Trimetrexate Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 10 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18268&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 5583 46518373 CHEMBL119 DB01157 C11154 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080578 COc1ccccc1NCc1ccc2nc(N)nc(N)c2n1 InChI=1S/C15H16N6O/c1-22-12-5-3-2-4-10(12)18-8-9-6-7-11-13(19-9)14(16)21-15(17)20-11/h2-7,18H,8H2,1H3,(H4,16,17,20,21) FNROHCXZBLVVQP-UHFFFAOYSA-N 50049605 6-[(2-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54523 Dihydrofolate reductase Rattus norvegicus 420 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049605&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457749 103979917 CHEMBL54523 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080579 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)c(OC)c1 InChI=1S/C16H18N6O2/c1-23-10-4-6-11(13(7-10)24-2)19-8-9-3-5-12-14(20-9)15(17)22-16(18)21-12/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) COJSGYVKBDTFAU-UHFFFAOYSA-N 50049606 6-[(2,4-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL296382 Dihydrofolate reductase Rattus norvegicus 320 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049606&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466055 103979918 CHEMBL296382 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080580 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cc(Cl)c(Cl)c(Cl)c1 InChI=1S/C15H13Cl3N6/c1-24(8-4-9(16)12(18)10(17)5-8)6-7-2-3-11-13(21-7)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23) FVRDUZOKYWZFLL-UHFFFAOYSA-N 50049588 6-{[Methyl-(3,4,5-trichloro-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52698 Dihydrofolate reductase Rattus norvegicus 87.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049588&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462104 103979900 CHEMBL52698 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080581 Nc1nc(N)c2nc(CNc3c(Cl)cccc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-8-2-1-3-9(16)11(8)19-6-7-4-5-10-12(20-7)13(17)22-14(18)21-10/h1-5,19H,6H2,(H4,17,18,21,22) ZTWMSAMXGJCMLW-UHFFFAOYSA-N 50049608 6-[(2,6-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54913 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1000 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049608&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457775 103979920 CHEMBL54913 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080582 Nc1nc(N)c2nc(CNc3c(Cl)cccc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-8-2-1-3-9(16)11(8)19-6-7-4-5-10-12(20-7)13(17)22-14(18)21-10/h1-5,19H,6H2,(H4,17,18,21,22) ZTWMSAMXGJCMLW-UHFFFAOYSA-N 50049608 6-[(2,6-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54913 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 28 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049608&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457775 103979920 CHEMBL54913 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080583 CC(=O)c1ccc(cc1)N(CC#C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C19H18N6O/c1-3-10-25(15-7-4-13(5-8-15)12(2)26)11-14-6-9-16-17(22-14)18(20)24-19(21)23-16/h1,4-9H,10-11H2,2H3,(H4,20,21,23,24) SSWYRLKEHKZJPV-UHFFFAOYSA-N 50049599 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-ethanone::CHEMBL52953 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 220 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049599&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457770 103979911 CHEMBL52953 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080584 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccccc1Cl InChI=1S/C15H15ClN6/c1-22(12-5-3-2-4-10(12)16)8-9-6-7-11-13(19-9)14(17)21-15(18)20-11/h2-7H,8H2,1H3,(H4,17,18,20,21) GZLIYLWITBUHLE-UHFFFAOYSA-N 50049576 6-{[(2-Chloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53318 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 15 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049576&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462108 103979888 CHEMBL53318 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080585 Cc1c(cnc2c1c(nc(n2)N)N)Cc3cc(ccc3OC)OC InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) VJXSSYDSOJBUAV-UHFFFAOYSA-N 18224 6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine::[2-amino-6-(2,5-dimethoxybenzyl)-5-methyl-pyrido[2,3-d]pyrimidin-4-yl]amine;2-hydroxyethanesulfonic acid::PTX::CHEMBL7492::Piritrexim Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 17 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18224&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search MXA 1DLR,1U71 54369 46518330 CHEMBL7492 DB03695 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080586 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc2ccccc2c1 InChI=1S/C19H18N6/c1-25(15-8-6-12-4-2-3-5-13(12)10-15)11-14-7-9-16-17(22-14)18(20)24-19(21)23-16/h2-10H,11H2,1H3,(H4,20,21,23,24) XVMYUHGKEGJVTF-UHFFFAOYSA-N 50049583 6-[(Methyl-naphthalen-2-yl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55727 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 16 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049583&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462099 103979895 CHEMBL55727 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080587 COc1cccc(NCc2ccc3nc(N)nc(N)c3n2)c1 InChI=1S/C15H16N6O/c1-22-11-4-2-3-9(7-11)18-8-10-5-6-12-13(19-10)14(16)21-15(17)20-12/h2-7,18H,8H2,1H3,(H4,16,17,20,21) VUDSXUWVNZOREL-UHFFFAOYSA-N 50049577 6-[(3-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52836 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1700 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049577&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457748 103979889 CHEMBL52836 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080588 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cc(Cl)ccc1Cl InChI=1S/C15H14Cl2N6/c1-23(12-6-8(16)2-4-10(12)17)7-9-3-5-11-13(20-9)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) MLHOJOGIBNGAAO-UHFFFAOYSA-N 50049579 6-{[(2,5-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55191 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 150 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049579&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462107 103979891 CHEMBL55191 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080589 Nc1nc(N)c2nc(CNc3c(Cl)cccc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-8-2-1-3-9(16)11(8)19-6-7-4-5-10-12(20-7)13(17)22-14(18)21-10/h1-5,19H,6H2,(H4,17,18,21,22) ZTWMSAMXGJCMLW-UHFFFAOYSA-N 50049608 6-[(2,6-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54913 Dihydrofolate reductase Rattus norvegicus 82 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049608&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457775 103979920 CHEMBL54913 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080590 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(Cl)c(Cl)c1 InChI=1S/C15H14Cl2N6/c1-23(9-3-4-10(16)11(17)6-9)7-8-2-5-12-13(20-8)14(18)22-15(19)21-12/h2-6H,7H2,1H3,(H4,18,19,21,22) DIJUWZJIGDFPAA-UHFFFAOYSA-N 50031869 6-{[(4,5-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::6-(((3,4-dichlorophenyl)(methyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL300603 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 38 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031869&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462102 103940431 CHEMBL300603 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080591 Nc1nc(N)c2nc(CSc3ccccc3)cnc2n1 InChI=1S/C13H12N6S/c14-11-10-12(19-13(15)18-11)16-6-8(17-10)7-20-9-4-2-1-3-5-9/h1-6H,7H2,(H4,14,15,16,18,19) ZJOATKLQTCGUSP-UHFFFAOYSA-N 50049602 6-Phenylsulfanylmethyl-pteridine-2,4-diamine::CHEMBL279243 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 9500 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049602&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 314604 103979914 CHEMBL279243 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080592 Nc1nc(N)c2nc(CNc3cc(Cl)c(Cl)c(Cl)c3)ccc2n1 InChI=1S/C14H11Cl3N6/c15-8-3-7(4-9(16)11(8)17)20-5-6-1-2-10-12(21-6)13(18)23-14(19)22-10/h1-4,20H,5H2,(H4,18,19,22,23) JBJCNGDWWRTSBU-UHFFFAOYSA-N 50049589 6-[(3,4,5-Trichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53420 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 660.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049589&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457774 103979901 CHEMBL53420 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080593 COc1ccccc1NCc1ccc2nc(N)nc(N)c2n1 InChI=1S/C15H16N6O/c1-22-12-5-3-2-4-10(12)18-8-9-6-7-11-13(19-9)14(16)21-15(17)20-11/h2-7,18H,8H2,1H3,(H4,16,17,20,21) FNROHCXZBLVVQP-UHFFFAOYSA-N 50049605 6-[(2-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54523 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 2700 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049605&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457749 103979917 CHEMBL54523 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080594 Nc1nc(N)c2nc(CSc3ccc4ccccc4c3)ccc2n1 InChI=1S/C18H15N5S/c19-17-16-15(22-18(20)23-17)8-6-13(21-16)10-24-14-7-5-11-3-1-2-4-12(11)9-14/h1-9H,10H2,(H4,19,20,22,23) KZQPPNIWGDASNT-UHFFFAOYSA-N 50049598 6-(Naphthalen-2-ylsulfanylmethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292143 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 48 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049598&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 466053 103979910 CHEMBL292143 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080595 COc1ccc(N(C)Cc2ccc3nc(N)nc(N)c3n2)c(OC)c1 InChI=1S/C17H20N6O2/c1-23(13-7-5-11(24-2)8-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) AVMATARNDBSZRC-UHFFFAOYSA-N 50049603 6-{[(2,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL299174 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 160 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049603&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462097 103979915 CHEMBL299174 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080596 Nc1nc(N)c2nc(CNc3cc(Cl)ccc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-7-1-3-9(16)11(5-7)19-6-8-2-4-10-12(20-8)13(17)22-14(18)21-10/h1-5,19H,6H2,(H4,17,18,21,22) NIOYPZTZXRUMAN-UHFFFAOYSA-N 50049592 6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292212 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1600 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049592&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462106 103979904 CHEMBL292212 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080597 COc1ccc(OC)c(NCc2ccc3nc(N)nc(N)c3n2)c1 InChI=1S/C16H18N6O2/c1-23-10-4-6-13(24-2)12(7-10)19-8-9-3-5-11-14(20-9)15(17)22-16(18)21-11/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) PIKOPKOXFNIUMO-UHFFFAOYSA-N 50031872 6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::6-((2,5-dimethoxyphenylamino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52947 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 4400 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031872&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457778 103940434 CHEMBL52947 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080598 COc1ccc(cc1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C17H20N6O2/c1-23(11-5-7-13(24-2)14(8-11)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) NZYUGDPIZKTBQD-UHFFFAOYSA-N 50049609 6-{[(3,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL57624 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 91 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049609 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049609&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462096 103979921 CHEMBL57624 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080599 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cccc(Cl)c1 InChI=1S/C15H15ClN6/c1-22(11-4-2-3-9(16)7-11)8-10-5-6-12-13(19-10)14(17)21-15(18)20-12/h2-7H,8H2,1H3,(H4,17,18,20,21) YGMFWJRAPSYNFQ-UHFFFAOYSA-N 50031866 6-(((3-chlorophenyl)(methyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(3-Chloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54399 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 2100 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031866&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 464891 103940428 CHEMBL54399 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080600 Nc1nc(N)c2nc(CNc3ccccc3Cl)ccc2n1 InChI=1S/C14H13ClN6/c15-9-3-1-2-4-10(9)18-7-8-5-6-11-12(19-8)13(16)21-14(17)20-11/h1-6,18H,7H2,(H4,16,17,20,21) UXOVXFBHRPRGRY-UHFFFAOYSA-N 50049594 6-[(2-Chloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53165 Dihydrofolate reductase Rattus norvegicus 140 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049594&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457750 103979906 CHEMBL53165 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080601 Nc1nc(N)c2nc(CNc3ccc(Cl)c(Cl)c3)ccc2n1 InChI=1S/C14H12Cl2N6/c15-9-3-1-7(5-10(9)16)19-6-8-2-4-11-12(20-8)13(17)22-14(18)21-11/h1-5,19H,6H2,(H4,17,18,21,22) YAMIFIPZNRDIHD-UHFFFAOYSA-N 50049600 6-[(3,4-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292427 Dihydrofolate reductase Rattus norvegicus 54.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049600&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457744 103979912 CHEMBL292427 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080602 Nc1nc(N)c2nc(CSc3cccc4ccccc34)ccc2n1 InChI=1S/C18H15N5S/c19-17-16-14(22-18(20)23-17)9-8-12(21-16)10-24-15-7-3-5-11-4-1-2-6-13(11)15/h1-9H,10H2,(H4,19,20,22,23) KUKKYMVHCDIMNT-UHFFFAOYSA-N 50049595 6-(Naphthalen-1-ylsulfanylmethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55656 Dihydrofolate reductase Rattus norvegicus 160 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049595&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466052 103979907 CHEMBL55656 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080603 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(Cl)c(Cl)c1 InChI=1S/C15H14Cl2N6/c1-23(9-3-4-10(16)11(17)6-9)7-8-2-5-12-13(20-8)14(18)22-15(19)21-12/h2-6H,7H2,1H3,(H4,18,19,21,22) DIJUWZJIGDFPAA-UHFFFAOYSA-N 50031869 6-{[(4,5-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::6-(((3,4-dichlorophenyl)(methyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL300603 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 27 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031869&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462102 103940431 CHEMBL300603 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080604 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(Cl)cc1Cl InChI=1S/C15H14Cl2N6/c1-23(12-5-2-8(16)6-10(12)17)7-9-3-4-11-13(20-9)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) HFLAIFUOYXPTMS-UHFFFAOYSA-N 50049610 6-{[(2,4-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54732 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 50 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049610 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049610&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462105 103979922 CHEMBL54732 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080605 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccccc1 InChI=1S/C15H16N6/c1-21(11-5-3-2-4-6-11)9-10-7-8-12-13(18-10)14(16)20-15(17)19-12/h2-8H,9H2,1H3,(H4,16,17,19,20) VLGOZDDHGVMTHG-UHFFFAOYSA-N 50049611 6-[(Methyl-phenyl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55063 Dihydrofolate reductase Rattus norvegicus 24 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049611 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049611&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462103 103979923 CHEMBL55063 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080606 Nc1nc(N)c2nc(CNc3ccccc3)ccc2n1 InChI=1S/C14H14N6/c15-13-12-11(19-14(16)20-13)7-6-10(18-12)8-17-9-4-2-1-3-5-9/h1-7,17H,8H2,(H4,15,16,19,20) SHGASZWNAPZHFB-UHFFFAOYSA-N 50049593 6-Phenylaminomethyl-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54733 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1700 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049593&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457773 103979905 CHEMBL54733 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080607 Nc1nc(N)c2nc(CNc3ccccc3Cl)ccc2n1 InChI=1S/C14H13ClN6/c15-9-3-1-2-4-10(9)18-7-8-5-6-11-12(19-8)13(16)21-14(17)20-11/h1-6,18H,7H2,(H4,16,17,20,21) UXOVXFBHRPRGRY-UHFFFAOYSA-N 50049594 6-[(2-Chloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53165 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 530 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049594&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457750 103979906 CHEMBL53165 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080608 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cccc2ccccc12 InChI=1S/C19H18N6/c1-25(16-8-4-6-12-5-2-3-7-14(12)16)11-13-9-10-15-17(22-13)18(20)24-19(21)23-15/h2-10H,11H2,1H3,(H4,20,21,23,24) YKSUMKODGROPHK-UHFFFAOYSA-N 50049604 6-[(Methyl-naphthalen-1-yl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54538 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 40 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049604&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462100 103979916 CHEMBL54538 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080609 Nc1nc(N)c2nc(CN(CC#C)c3ccc(cc3)C(=O)C(F)(F)F)ccc2n1 InChI=1S/C19H15F3N6O/c1-2-9-28(13-6-3-11(4-7-13)16(29)19(20,21)22)10-12-5-8-14-15(25-12)17(23)27-18(24)26-14/h1,3-8H,9-10H2,(H4,23,24,26,27) ZPVABTSOZGBWAC-UHFFFAOYSA-N 50049585 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-2,2,2-trifluoro-ethanone::CHEMBL53872 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 120 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049585&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457772 103979897 CHEMBL53872 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080610 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(Cl)c(Cl)c1 InChI=1S/C15H14Cl2N6/c1-23(9-3-4-10(16)11(17)6-9)7-8-2-5-12-13(20-8)14(18)22-15(19)21-12/h2-6H,7H2,1H3,(H4,18,19,21,22) DIJUWZJIGDFPAA-UHFFFAOYSA-N 50031869 6-{[(4,5-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::6-(((3,4-dichlorophenyl)(methyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(3,4-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL300603 Dihydrofolate reductase Rattus norvegicus 17 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031869 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031869&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462102 103940431 CHEMBL300603 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080611 COc1cc(cc(c1OC)OC)Cc2cnc(nc2N)N InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) IEDVJHCEMCRBQM-UHFFFAOYSA-N 18069 CHEMBL22::TMP::Trimethoprim (TMP)::5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine::Trimethoprim::US10870625, Compound TMP Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 2700 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18069&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search TOP 1DG5,1DYR,2BFM,2W3A,2W3V,2W9G,2W9H,2W9S,3FL9,3FRB,3FRE,3JW3,3JW5,3N0H,3S3V,3TQ8,4G8Z,4KM2,4XT7,6RUL,6RUM,6XG4,6XG5,7F3Z,7MYL,7MYM,7NAE,7R6G,8SZE,8VTC 5578 46518184 CHEMBL22 DB00440 C01965 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080612 Nc1nc(N)c2nc(CNc3ccc(Cl)cc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-7-1-3-10(9(16)5-7)19-6-8-2-4-11-12(20-8)13(17)22-14(18)21-11/h1-5,19H,6H2,(H4,17,18,21,22) DMNKLTYJZVLTIU-UHFFFAOYSA-N 50049578 6-[(2,4-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292634 Dihydrofolate reductase Rattus norvegicus 88.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049578&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466051 103979890 CHEMBL292634 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080613 CN(Cc1ccc2nc(N)nc(N)c2n1)c1c(Cl)cc(Cl)cc1Cl InChI=1S/C15H13Cl3N6/c1-24(13-9(17)4-7(16)5-10(13)18)6-8-2-3-11-12(21-8)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23) RQTLSQCDNIJYOU-UHFFFAOYSA-N 50049591 6-{[Methyl-(2,4,6-trichloro-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52930 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 44 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049591&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462110 103979903 CHEMBL52930 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080614 Cc1c(cnc2c1c(nc(n2)N)N)Cc3cc(ccc3OC)OC InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) VJXSSYDSOJBUAV-UHFFFAOYSA-N 18224 6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine::[2-amino-6-(2,5-dimethoxybenzyl)-5-methyl-pyrido[2,3-d]pyrimidin-4-yl]amine;2-hydroxyethanesulfonic acid::PTX::CHEMBL7492::Piritrexim Dihydrofolate reductase Rattus norvegicus 1.5 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18224&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search MXA 1DLR,1U71 54369 46518330 CHEMBL7492 DB03695 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080615 Cc1c(cnc2c1c(nc(n2)N)N)Cc3cc(ccc3OC)OC InChI=1S/C17H19N5O2/c1-9-11(6-10-7-12(23-2)4-5-13(10)24-3)8-20-16-14(9)15(18)21-17(19)22-16/h4-5,7-8H,6H2,1-3H3,(H4,18,19,20,21,22) VJXSSYDSOJBUAV-UHFFFAOYSA-N 18224 6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine::[2-amino-6-(2,5-dimethoxybenzyl)-5-methyl-pyrido[2,3-d]pyrimidin-4-yl]amine;2-hydroxyethanesulfonic acid::PTX::CHEMBL7492::Piritrexim Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18224&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search MXA 54369 46518330 CHEMBL7492 DB03695 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080616 CN(Cc1ccc2nc(N)nc(N)c2n1)c1c(Cl)cc(Cl)cc1Cl InChI=1S/C15H13Cl3N6/c1-24(13-9(17)4-7(16)5-10(13)18)6-8-2-3-11-12(21-8)14(19)23-15(20)22-11/h2-5H,6H2,1H3,(H4,19,20,22,23) RQTLSQCDNIJYOU-UHFFFAOYSA-N 50049591 6-{[Methyl-(2,4,6-trichloro-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52930 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 120 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049591&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462110 103979903 CHEMBL52930 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080617 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccccc1Cl InChI=1S/C15H15ClN6/c1-22(12-5-3-2-4-10(12)16)8-9-6-7-11-13(19-9)14(17)21-15(18)20-11/h2-7H,8H2,1H3,(H4,17,18,20,21) GZLIYLWITBUHLE-UHFFFAOYSA-N 50049576 6-{[(2-Chloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53318 Dihydrofolate reductase Rattus norvegicus 120 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049576&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462108 103979888 CHEMBL53318 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080618 Nc1nc(N)c2nc(CNc3ccc(Cl)cc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-7-1-3-10(9(16)5-7)19-6-8-2-4-11-12(20-8)13(17)22-14(18)21-11/h1-5,19H,6H2,(H4,17,18,21,22) DMNKLTYJZVLTIU-UHFFFAOYSA-N 50049578 6-[(2,4-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292634 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 730 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049578&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466051 103979890 CHEMBL292634 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080619 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(Cl)cc1Cl InChI=1S/C15H14Cl2N6/c1-23(12-5-2-8(16)6-10(12)17)7-9-3-4-11-13(20-9)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) HFLAIFUOYXPTMS-UHFFFAOYSA-N 50049610 6-{[(2,4-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54732 Dihydrofolate reductase Rattus norvegicus 58 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049610 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049610&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462105 103979922 CHEMBL54732 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080620 COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) NOYPYLRCIDNJJB-UHFFFAOYSA-N 18268 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine::TMQ::CHEMBL119::Trimetrexate::US11111252, Compound TMQ::US11530198, Example Trimetrexate Dihydrofolate reductase Rattus norvegicus 3 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18268&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 5583 46518373 CHEMBL119 DB01157 C11154 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080621 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1OC InChI=1S/C16H18N6O2/c1-23-12-6-4-9(7-13(12)24-2)19-8-10-3-5-11-14(20-10)15(17)22-16(18)21-11/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) ONOFLDOKBQQVPB-UHFFFAOYSA-N 50049597 6-[(3,4-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55928 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 90 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049597&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457746 103979909 CHEMBL55928 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080622 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cccc2ccccc12 InChI=1S/C19H18N6/c1-25(16-8-4-6-12-5-2-3-7-14(12)16)11-13-9-10-15-17(22-13)18(20)24-19(21)23-15/h2-10H,11H2,1H3,(H4,20,21,23,24) YKSUMKODGROPHK-UHFFFAOYSA-N 50049604 6-[(Methyl-naphthalen-1-yl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54538 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 18 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049604&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462100 103979916 CHEMBL54538 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080623 COc1ccccc1N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(12-5-3-4-6-13(12)23-2)9-10-7-8-11-14(19-10)15(17)21-16(18)20-11/h3-8H,9H2,1-2H3,(H4,17,18,20,21) VLMGXHQHHQMEPY-UHFFFAOYSA-N 50049612 6-{[(2-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(6-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53974 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 510 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049612&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462101 103979924 CHEMBL53974 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080624 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)c(OC)c1 InChI=1S/C16H18N6O2/c1-23-10-4-6-11(13(7-10)24-2)19-8-9-3-5-12-14(20-9)15(17)22-16(18)21-12/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) COJSGYVKBDTFAU-UHFFFAOYSA-N 50049606 6-[(2,4-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL296382 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 5500 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049606&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466055 103979918 CHEMBL296382 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080625 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccccc1 InChI=1S/C15H16N6/c1-21(11-5-3-2-4-6-11)9-10-7-8-12-13(18-10)14(16)20-15(17)19-12/h2-8H,9H2,1H3,(H4,16,17,19,20) VLGOZDDHGVMTHG-UHFFFAOYSA-N 50049611 6-[(Methyl-phenyl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55063 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 8.4 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049611 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049611&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462103 103979923 CHEMBL55063 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080626 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1OC InChI=1S/C16H18N6O2/c1-23-12-6-4-9(7-13(12)24-2)19-8-10-3-5-11-14(20-10)15(17)22-16(18)21-11/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) ONOFLDOKBQQVPB-UHFFFAOYSA-N 50049597 6-[(3,4-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55928 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 900 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049597&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457746 103979909 CHEMBL55928 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080627 COc1ccccc1N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(12-5-3-4-6-13(12)23-2)9-10-7-8-11-14(19-10)15(17)21-16(18)20-11/h3-8H,9H2,1-2H3,(H4,17,18,20,21) VLMGXHQHHQMEPY-UHFFFAOYSA-N 50049612 6-{[(2-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(6-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53974 Dihydrofolate reductase Rattus norvegicus 120 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049612&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462101 103979924 CHEMBL53974 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080628 COc1ccc(cc1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C17H20N6O2/c1-23(11-5-7-13(24-2)14(8-11)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) NZYUGDPIZKTBQD-UHFFFAOYSA-N 50049609 6-{[(3,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL57624 Dihydrofolate reductase Rattus norvegicus 2.7 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049609 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049609&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462096 103979921 CHEMBL57624 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080629 COc1cccc(c1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(11-4-3-5-12(8-11)23-2)9-10-6-7-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) VUOWLRUPFRBDGR-UHFFFAOYSA-N 50049607 6-{[(3-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54792 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 97 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049607&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462098 103979919 CHEMBL54792 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080630 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)c(OC)c1 InChI=1S/C16H18N6O2/c1-23-10-4-6-11(13(7-10)24-2)19-8-9-3-5-12-14(20-9)15(17)22-16(18)21-12/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) COJSGYVKBDTFAU-UHFFFAOYSA-N 50049606 6-[(2,4-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL296382 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 140 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049606&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 466055 103979918 CHEMBL296382 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080631 Nc1nc(N)c2nc(CNc3ccc(Cl)c(Cl)c3)ccc2n1 InChI=1S/C14H12Cl2N6/c15-9-3-1-7(5-10(9)16)19-6-8-2-4-11-12(20-8)13(17)22-14(18)21-11/h1-5,19H,6H2,(H4,17,18,21,22) YAMIFIPZNRDIHD-UHFFFAOYSA-N 50049600 6-[(3,4-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292427 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 410 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049600&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457744 103979912 CHEMBL292427 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080632 Nc1nc(N)c2nc(CSc3ccccc3)cnc2n1 InChI=1S/C13H12N6S/c14-11-10-12(19-13(15)18-11)16-6-8(17-10)7-20-9-4-2-1-3-5-9/h1-6H,7H2,(H4,14,15,16,18,19) ZJOATKLQTCGUSP-UHFFFAOYSA-N 50049602 6-Phenylsulfanylmethyl-pteridine-2,4-diamine::CHEMBL279243 Dihydrofolate reductase Rattus norvegicus 246000 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049602&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 314604 103979914 CHEMBL279243 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080633 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc2ccccc2c1 InChI=1S/C19H18N6/c1-25(15-8-6-12-4-2-3-5-13(12)10-15)11-14-7-9-16-17(22-14)18(20)24-19(21)23-16/h2-10H,11H2,1H3,(H4,20,21,23,24) XVMYUHGKEGJVTF-UHFFFAOYSA-N 50049583 6-[(Methyl-naphthalen-2-yl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55727 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 52.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049583&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462099 103979895 CHEMBL55727 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080634 COc1ccc(cc1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(11-4-6-12(23-2)7-5-11)9-10-3-8-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) BSHIEINVRLJMLH-UHFFFAOYSA-N 50049601 6-{[(4-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL415962 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 16 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049601 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049601&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457752 103979913 CHEMBL415962 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080635 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cccc(Cl)c1 InChI=1S/C15H15ClN6/c1-22(11-4-2-3-9(16)7-11)8-10-5-6-12-13(19-10)14(17)21-15(18)20-12/h2-7H,8H2,1H3,(H4,17,18,20,21) YGMFWJRAPSYNFQ-UHFFFAOYSA-N 50031866 6-(((3-chlorophenyl)(methyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(3-Chloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54399 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 20 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031866 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031866&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 464891 103940428 CHEMBL54399 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080636 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(cc1)C(C)=O InChI=1S/C17H18N6O/c1-10(24)11-3-6-13(7-4-11)23(2)9-12-5-8-14-15(20-12)16(18)22-17(19)21-14/h3-8H,9H2,1-2H3,(H4,18,19,21,22) GATWXZCVAPEINN-UHFFFAOYSA-N 50049587 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-phenyl}-ethanone::CHEMBL55012 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 15 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049587&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457769 103979899 CHEMBL55012 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080637 COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) NOYPYLRCIDNJJB-UHFFFAOYSA-N 18268 5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}quinazoline-2,4-diamine::TMQ::CHEMBL119::Trimetrexate::US11111252, Compound TMQ::US11530198, Example Trimetrexate Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18268&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 5583 46518373 CHEMBL119 DB01157 C11154 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080638 COc1ccc(OC)c(NCc2ccc3nc(N)nc(N)c3n2)c1 InChI=1S/C16H18N6O2/c1-23-10-4-6-13(24-2)12(7-10)19-8-9-3-5-11-14(20-9)15(17)22-16(18)21-11/h3-7,19H,8H2,1-2H3,(H4,17,18,21,22) PIKOPKOXFNIUMO-UHFFFAOYSA-N 50031872 6-[(2,5-Dimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::6-((2,5-dimethoxyphenylamino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52947 Dihydrofolate reductase Rattus norvegicus 280 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031872&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457778 103940434 CHEMBL52947 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080639 COc1ccc(OC)c(c1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C17H20N6O2/c1-23(13-8-11(24-2)5-7-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) MBIDRNHTYNBDML-UHFFFAOYSA-N 50049613 6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL301105 Dihydrofolate reductase Rattus norvegicus 50 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049613 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049613&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457777 103979925 CHEMBL301105 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080640 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)C(F)(F)F InChI=1S/C17H15F3N6O/c1-26(11-5-2-9(3-6-11)14(27)17(18,19)20)8-10-4-7-12-13(23-10)15(21)25-16(22)24-12/h2-7H,8H2,1H3,(H4,21,22,24,25) ZFUKPZOQUMPCIJ-UHFFFAOYSA-N 50049590 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-phenyl}-2,2,2-trifluoro-ethanone::CHEMBL55049 Dihydrofolate reductase Rattus norvegicus 32 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049590&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457771 103979902 CHEMBL55049 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080641 COc1ccc(N(C)Cc2ccc3nc(N)nc(N)c3n2)c(OC)c1 InChI=1S/C17H20N6O2/c1-23(13-7-5-11(24-2)8-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) AVMATARNDBSZRC-UHFFFAOYSA-N 50049603 6-{[(2,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL299174 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 14 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049603&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462097 103979915 CHEMBL299174 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080642 Nc1nc(N)c2nc(CSc3ccccc3)ccc2n1 InChI=1S/C14H13N5S/c15-13-12-11(18-14(16)19-13)7-6-9(17-12)8-20-10-4-2-1-3-5-10/h1-7H,8H2,(H4,15,16,18,19) DKLBFJLXPKVFCS-UHFFFAOYSA-N 50049581 6-Phenylsulfanylmethyl-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL300886 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 130 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049581&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 466050 103979893 CHEMBL300886 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080643 Nc1nc(N)c2nc(CNc3cc(Cl)ccc3Cl)ccc2n1 InChI=1S/C14H12Cl2N6/c15-7-1-3-9(16)11(5-7)19-6-8-2-4-10-12(20-8)13(17)22-14(18)21-10/h1-5,19H,6H2,(H4,17,18,21,22) NIOYPZTZXRUMAN-UHFFFAOYSA-N 50049592 6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292212 Dihydrofolate reductase Rattus norvegicus 200 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049592&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462106 103979904 CHEMBL292212 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080644 COc1ccc(cc1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(11-4-6-12(23-2)7-5-11)9-10-3-8-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) BSHIEINVRLJMLH-UHFFFAOYSA-N 50049601 6-{[(4-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL415962 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 250 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049601 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049601&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457752 103979913 CHEMBL415962 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080645 Nc1nc(N)c2nc(CNc3ccccc3)ccc2n1 InChI=1S/C14H14N6/c15-13-12-11(19-14(16)20-13)7-6-10(18-12)8-17-9-4-2-1-3-5-9/h1-7,17H,8H2,(H4,15,16,19,20) SHGASZWNAPZHFB-UHFFFAOYSA-N 50049593 6-Phenylaminomethyl-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54733 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 85.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049593&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457773 103979905 CHEMBL54733 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080646 Nc1nc(N)c2nc(CSc3cccc4ccccc34)ccc2n1 InChI=1S/C18H15N5S/c19-17-16-14(22-18(20)23-17)9-8-12(21-16)10-24-15-7-3-5-11-4-1-2-6-13(11)15/h1-9H,10H2,(H4,19,20,22,23) KUKKYMVHCDIMNT-UHFFFAOYSA-N 50049595 6-(Naphthalen-1-ylsulfanylmethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55656 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 470 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049595&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466052 103979907 CHEMBL55656 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080647 Nc1nc(N)c2nc(CNc3cccc(Cl)c3)ccc2n1 InChI=1S/C14H13ClN6/c15-8-2-1-3-9(6-8)18-7-10-4-5-11-12(19-10)13(16)21-14(17)20-11/h1-6,18H,7H2,(H4,16,17,20,21) UYTSDXNCTIAVMW-UHFFFAOYSA-N 50049614 6-[(3-Chloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54618 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 2000 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049614&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457747 103979926 CHEMBL54618 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080648 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccccc1 InChI=1S/C15H16N6/c1-21(11-5-3-2-4-6-11)9-10-7-8-12-13(18-10)14(16)20-15(17)19-12/h2-8H,9H2,1H3,(H4,16,17,19,20) VLGOZDDHGVMTHG-UHFFFAOYSA-N 50049611 6-[(Methyl-phenyl-amino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55063 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 290 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049611 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049611&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462103 103979923 CHEMBL55063 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080649 COc1cc(cc(OC)c1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C18H22N6O3/c1-24(11-7-13(25-2)16(27-4)14(8-11)26-3)9-10-5-6-12-15(21-10)17(19)23-18(20)22-12/h5-8H,9H2,1-4H3,(H4,19,20,22,23) DQLHWXMDFBDATJ-UHFFFAOYSA-N 50031867 6-((methyl(3,4,5-trimethoxyphenyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52688 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 130 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031867&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 464889 103940429 CHEMBL52688 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080650 CC(=O)c1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1 InChI=1S/C16H16N6O/c1-9(23)10-2-4-11(5-3-10)19-8-12-6-7-13-14(20-12)15(17)22-16(18)21-13/h2-7,19H,8H2,1H3,(H4,17,18,21,22) OSWHAJUIPNBZGO-UHFFFAOYSA-N 50049575 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-amino]-phenyl}-ethanone::CHEMBL301795 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 410 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049575&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457768 103979887 CHEMBL301795 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080651 Nc1nc(N)c2nc(CNc3cccc4ccccc34)ccc2n1 InChI=1S/C18H16N6/c19-17-16-15(23-18(20)24-17)9-8-12(22-16)10-21-14-7-3-5-11-4-1-2-6-13(11)14/h1-9,21H,10H2,(H4,19,20,23,24) UHHPRQVHWBEBHX-UHFFFAOYSA-N 50049582 6-(Naphthalen-1-ylaminomethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL299140 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 230 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049582&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466054 103979894 CHEMBL299140 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080652 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(Cl)cc1Cl InChI=1S/C15H14Cl2N6/c1-23(12-5-2-8(16)6-10(12)17)7-9-3-4-11-13(20-9)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) HFLAIFUOYXPTMS-UHFFFAOYSA-N 50049610 6-{[(2,4-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54732 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 500 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049610 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049610&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462105 103979922 CHEMBL54732 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080653 COc1cc(cc(c1OC)OC)Cc2cnc(nc2N)N InChI=1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18) IEDVJHCEMCRBQM-UHFFFAOYSA-N 18069 CHEMBL22::TMP::Trimethoprim (TMP)::5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine::Trimethoprim::US10870625, Compound TMP Dihydrofolate reductase Rattus norvegicus 130000 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=18069 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=18069&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search TOP 1DG5,1DYR,2BFM,2W3A,2W3V,2W9G,2W9H,2W9S,3FL9,3FRB,3FRE,3JW3,3JW5,3N0H,3S3V,3TQ8,4G8Z,4KM2,4XT7,6RUL,6RUM,6XG4,6XG5,7F3Z,7MYL,7MYM,7NAE,7R6G,8SZE,8VTC 5578 46518184 CHEMBL22 DB00440 C01965 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080654 COc1cc(cc(OC)c1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C18H22N6O3/c1-24(11-7-13(25-2)16(27-4)14(8-11)26-3)9-10-5-6-12-15(21-10)17(19)23-18(20)22-12/h5-8H,9H2,1-4H3,(H4,19,20,22,23) DQLHWXMDFBDATJ-UHFFFAOYSA-N 50031867 6-((methyl(3,4,5-trimethoxyphenyl)amino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[Methyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52688 Dihydrofolate reductase Rattus norvegicus 26 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031867 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031867&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 464889 103940429 CHEMBL52688 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080655 COc1ccc(OC)c(c1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C17H20N6O2/c1-23(13-8-11(24-2)5-7-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) MBIDRNHTYNBDML-UHFFFAOYSA-N 50049613 6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL301105 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 210 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049613 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049613&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457777 103979925 CHEMBL301105 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080656 Nc1nc(N)c2nc(CNc3cccc(Cl)c3)ccc2n1 InChI=1S/C14H13ClN6/c15-8-2-1-3-9(6-8)18-7-10-4-5-11-12(19-10)13(16)21-14(17)20-11/h1-6,18H,7H2,(H4,16,17,20,21) UYTSDXNCTIAVMW-UHFFFAOYSA-N 50049614 6-[(3-Chloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54618 Dihydrofolate reductase Rattus norvegicus 140 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049614&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457747 103979926 CHEMBL54618 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080657 COc1ccccc1NCc1ccc2nc(N)nc(N)c2n1 InChI=1S/C15H16N6O/c1-22-12-5-3-2-4-10(12)18-8-9-6-7-11-13(19-9)14(16)21-15(17)20-11/h2-7,18H,8H2,1H3,(H4,16,17,20,21) FNROHCXZBLVVQP-UHFFFAOYSA-N 50049605 6-[(2-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54523 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 120 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049605&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457749 103979917 CHEMBL54523 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080658 COc1cccc(NCc2ccc3nc(N)nc(N)c3n2)c1 InChI=1S/C15H16N6O/c1-22-11-4-2-3-9(7-11)18-8-10-5-6-12-13(19-10)14(16)21-15(17)20-12/h2-7,18H,8H2,1H3,(H4,16,17,20,21) VUDSXUWVNZOREL-UHFFFAOYSA-N 50049577 6-[(3-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52836 Dihydrofolate reductase Rattus norvegicus 200 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049577&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457748 103979889 CHEMBL52836 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080659 COc1ccc(NCc2ccc3nc(N)nc(N)c3n2)cc1 InChI=1S/C15H16N6O/c1-22-11-5-2-9(3-6-11)18-8-10-4-7-12-13(19-10)14(16)21-15(17)20-12/h2-7,18H,8H2,1H3,(H4,16,17,20,21) FFOCJHIGLIUZJX-UHFFFAOYSA-N 50049584 6-[(4-Methoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL52777 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 54.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049584&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457776 103979896 CHEMBL52777 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080660 COc1ccccc1N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(12-5-3-4-6-13(12)23-2)9-10-7-8-11-14(19-10)15(17)21-16(18)20-11/h3-8H,9H2,1-2H3,(H4,17,18,20,21) VLMGXHQHHQMEPY-UHFFFAOYSA-N 50049612 6-{[(2-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::6-{[(6-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL53974 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 26 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049612&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462101 103979924 CHEMBL53974 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080661 CC(=O)c1ccc(cc1)N(CC#C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C19H18N6O/c1-3-10-25(15-7-4-13(5-8-15)12(2)26)11-14-6-9-16-17(22-14)18(20)24-19(21)23-16/h1,4-9H,10-11H2,2H3,(H4,20,21,23,24) SSWYRLKEHKZJPV-UHFFFAOYSA-N 50049599 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-prop-2-ynyl-amino]-phenyl}-ethanone::CHEMBL52953 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 20 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049599&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457770 103979911 CHEMBL52953 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080662 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(cc1)C(C)=O InChI=1S/C17H18N6O/c1-10(24)11-3-6-13(7-4-11)23(2)9-12-5-8-14-15(20-12)16(18)22-17(19)21-14/h3-8H,9H2,1-2H3,(H4,18,19,21,22) GATWXZCVAPEINN-UHFFFAOYSA-N 50049587 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-phenyl}-ethanone::CHEMBL55012 Dihydrofolate reductase Rattus norvegicus 5.1 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049587&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457769 103979899 CHEMBL55012 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080663 CN(Cc1ccc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)C(F)(F)F InChI=1S/C17H15F3N6O/c1-26(11-5-2-9(3-6-11)14(27)17(18,19)20)8-10-4-7-12-13(23-10)15(21)25-16(22)24-12/h2-7H,8H2,1H3,(H4,21,22,24,25) ZFUKPZOQUMPCIJ-UHFFFAOYSA-N 50049590 1-{4-[(2,4-Diamino-pyrido[3,2-d]pyrimidin-6-ylmethyl)-methyl-amino]-phenyl}-2,2,2-trifluoro-ethanone::CHEMBL55049 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 46 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049590&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457771 103979902 CHEMBL55049 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080664 COc1ccc(SCc2cnc3nc(N)nc(N)c3c2C)cc1 InChI=1S/C16H17N5OS/c1-9-10(8-23-12-5-3-11(22-2)4-6-12)7-19-15-13(9)14(17)20-16(18)21-15/h3-7H,8H2,1-2H3,(H4,17,18,19,20,21) YYBYCBOPPNOBID-UHFFFAOYSA-N 50049596 6-(4-Methoxy-phenylsulfanylmethyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine::CHEMBL23911 Dihydrofolate reductase Rattus norvegicus 520 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049596&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 464984 103979908 CHEMBL23911 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080665 Nc1nc(N)c2nc(CNc3c(Cl)cc(Cl)cc3Cl)ccc2n1 InChI=1S/C14H11Cl3N6/c15-6-3-8(16)11(9(17)4-6)20-5-7-1-2-10-12(21-7)13(18)23-14(19)22-10/h1-4,20H,5H2,(H4,18,19,22,23) JZYLVYPKMNKCGP-UHFFFAOYSA-N 50049615 6-[(2,4,6-Trichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL51706 Dihydrofolate reductase Rattus norvegicus 570.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049615&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457779 103979927 CHEMBL51706 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080666 Nc1nc(N)c2nc(CNc3c(Cl)cc(Cl)cc3Cl)ccc2n1 InChI=1S/C14H11Cl3N6/c15-6-3-8(16)11(9(17)4-6)20-5-7-1-2-10-12(21-7)13(18)23-14(19)22-10/h1-4,20H,5H2,(H4,18,19,22,23) JZYLVYPKMNKCGP-UHFFFAOYSA-N 50049615 6-[(2,4,6-Trichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL51706 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 2000 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049615&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457779 103979927 CHEMBL51706 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080667 CN(Cc1ccc2nc(N)nc(N)c2n1)c1cc(Cl)ccc1Cl InChI=1S/C15H14Cl2N6/c1-23(12-6-8(16)2-4-10(12)17)7-9-3-5-11-13(20-9)14(18)22-15(19)21-11/h2-6H,7H2,1H3,(H4,18,19,21,22) MLHOJOGIBNGAAO-UHFFFAOYSA-N 50049579 6-{[(2,5-Dichloro-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55191 Dihydrofolate reductase Rattus norvegicus 47 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049579&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 462107 103979891 CHEMBL55191 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080668 Nc1nc(N)c2nc(CNc3cccc4ccccc34)ccc2n1 InChI=1S/C18H16N6/c19-17-16-15(23-18(20)24-17)9-8-12(22-16)10-21-14-7-3-5-11-4-1-2-6-13(11)14/h1-9,21H,10H2,(H4,19,20,23,24) UHHPRQVHWBEBHX-UHFFFAOYSA-N 50049582 6-(Naphthalen-1-ylaminomethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL299140 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 26 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049582&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 466054 103979894 CHEMBL299140 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080669 COc1cccc(c1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C16H18N6O/c1-22(11-4-3-5-12(8-11)23-2)9-10-6-7-13-14(19-10)15(17)21-16(18)20-13/h3-8H,9H2,1-2H3,(H4,17,18,20,21) VUOWLRUPFRBDGR-UHFFFAOYSA-N 50049607 6-{[(3-Methoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54792 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 15 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049607&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462098 103979919 CHEMBL54792 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080670 COc1ccc(cc1OC)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C17H20N6O2/c1-23(11-5-7-13(24-2)14(8-11)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) NZYUGDPIZKTBQD-UHFFFAOYSA-N 50049609 6-{[(3,4-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL57624 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 9.8 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049609 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049609&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 462096 103979921 CHEMBL57624 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080671 COc1cc(NCc2ccc3nc(N)nc(N)c3n2)cc(OC)c1OC InChI=1S/C17H20N6O3/c1-24-12-6-10(7-13(25-2)15(12)26-3)20-8-9-4-5-11-14(21-9)16(18)23-17(19)22-11/h4-7,20H,8H2,1-3H3,(H4,18,19,22,23) ASYMVCBDRFSMND-UHFFFAOYSA-N 50031868 6-[(3,4,5-Trimethoxy-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::6-((3,4,5-trimethoxyphenylamino)methyl)pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL55179 Dihydrofolate reductase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 2000 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50031868 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000382&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50031868&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 457751 103940430 CHEMBL55179 1 MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK Dihydrofolate reductase DYR_YEAST P07807 D6W2T9 50080672 Nc1nc(N)c2nc(CNc3c(Cl)cc(Cl)cc3Cl)ccc2n1 InChI=1S/C14H11Cl3N6/c15-6-3-8(16)11(9(17)4-6)20-5-7-1-2-10-12(21-7)13(18)23-14(19)22-10/h1-4,20H,5H2,(H4,18,19,22,23) JZYLVYPKMNKCGP-UHFFFAOYSA-N 50049615 6-[(2,4,6-Trichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL51706 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 46 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049615&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457779 103979927 CHEMBL51706 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080673 Nc1nc(N)c2nc(CSc3ccc4ccccc4c3)ccc2n1 InChI=1S/C18H15N5S/c19-17-16-15(22-18(20)23-17)8-6-13(21-16)10-24-14-7-5-11-3-1-2-4-12(11)9-14/h1-9H,10H2,(H4,19,20,22,23) KZQPPNIWGDASNT-UHFFFAOYSA-N 50049598 6-(Naphthalen-2-ylsulfanylmethyl)-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL292143 Dihydrofolate reductase Rattus norvegicus 86.0 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1910&target=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049598&enzyme=Dihydrofolate+reductase&column=ki&startPg=0&Increment=50&submit=Search 466053 103979910 CHEMBL292143 1 MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD Dihydrofolate reductase DYR_RAT Q920D2 50080674 Nc1nc(N)c2nc(CNc3cccc(Cl)c3)ccc2n1 InChI=1S/C14H13ClN6/c15-8-2-1-3-9(6-8)18-7-10-4-5-11-12(19-10)13(16)21-14(17)20-11/h1-6,18H,7H2,(H4,16,17,20,21) UYTSDXNCTIAVMW-UHFFFAOYSA-N 50049614 6-[(3-Chloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL54618 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 130 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049614&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457747 103979926 CHEMBL54618 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422 50080675 COc1ccc(OC)c(c1)N(C)Cc1ccc2nc(N)nc(N)c2n1 InChI=1S/C17H20N6O2/c1-23(13-8-11(24-2)5-7-14(13)25-3)9-10-4-6-12-15(20-10)16(18)22-17(19)21-12/h4-8H,9H2,1-3H3,(H4,18,19,21,22) MBIDRNHTYNBDML-UHFFFAOYSA-N 50049613 6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-pyrido[3,2-d]pyrimidine-2,4-diamine::CHEMBL301105 Bifunctional dihydrofolate reductase-thymidylate synthase Toxoplasma gondii 25 ChEMBL 10.1021/jm950918e 10.7270/Q2319TXB 8627607 Gangjee, A; Zhu, Y; Queener, SF; Francom, P; Broom, AD 6/25/1996 11/10/2009 Duquesne University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50049613 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=9977&target=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50049613&enzyme=Bifunctional+dihydrofolate+reductase-thymidylate+synthase&column=ki&startPg=0&Increment=50&submit=Search 457777 103979925 CHEMBL301105 1 MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKTGDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEGQQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPCDVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNGVPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEEDRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 7FGY,7FGX,7FGW,4KY4,4ECK,6N1T,6N1S,6AOI,6AOH,6AOG,5T0L,4KYA,4EIL Bifunctional dihydrofolate reductase-thymidylate synthase DRTS_TOXGO Q07422