BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 50043121 C[C@@H]1CCN([C@H](C1)C(O)=O)C(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1cccc2CC(C)CNc12 InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26) KXNPVXPOPUZYGB-UHFFFAOYSA-N 50038001 CHEMBL1166::(2R,4S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::MD-805::1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::1-[(2R,3S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2R,4R)-1-[(S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2S,4S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic acid::DK-7419::MCI-9038::1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid (Argatroban)::GN-1600::(S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::ARGATROBAN Prothrombin Homo sapiens 10 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038001&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 92722 103945452 CHEMBL1166 C04931 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50043122 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1nc2ccccc2s1 InChI=1S/C28H12N7O3S/c1-31-21(17-18-9-3-2-4-10-18)27(38)35-16-8-13-22(35)25(37)33-20(12-7-15-32-28(29)30)24(36)26-34-19-11-5-6-14-23(19)39-26/h2-6,9-11,14,20-22H QCCMGBCCBBJKNN-UHFFFAOYSA-N 50228853 RWJ-50353::(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL270437 Prothrombin Homo sapiens 23 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228853&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 9872263 104097965 CHEMBL270437 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50043123 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6]=O InChI=1S/C21H8N6O3/c1-24-17(13-15-7-3-2-4-8-15)20(30)27-12-6-10-18(27)19(29)26-16(14-28)9-5-11-25-21(22)23/h2-4,7-8,16-18H NZEAENHOWXTKPM-UHFFFAOYSA-N 50228863 1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]-1-[2-methylamino-3-phenyl-(2R)-propanoyl]-(5S)-dihydro-1H-5-pyrrolecarboxamide::Me-(D-Phe)-Pro-Arg-CHO::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid ((S)-1-formyl-4-guanidino-butyl)-amide::CHEMBL273196 Prothrombin Homo sapiens 23 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228863&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 122267 104097969 CHEMBL273196 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776947 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1nc2ccccc2s1 InChI=1S/C28H12N7O3S/c1-31-21(17-18-9-3-2-4-10-18)27(38)35-16-8-13-22(35)25(37)33-20(12-7-15-32-28(29)30)24(36)26-34-19-11-5-6-14-23(19)39-26/h2-6,9-11,14,20-22H QCCMGBCCBBJKNN-UHFFFAOYSA-N 50228853 RWJ-50353::(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL270437 Prothrombin Homo sapiens 0.19 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228853&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 9872263 104097965 CHEMBL270437 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776948 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2o1 InChI=1S/C28H35N7O4/c1-31-21(17-18-9-3-2-4-10-18)27(38)35-16-8-13-22(35)25(37)33-20(12-7-15-32-28(29)30)24(36)26-34-19-11-5-6-14-23(19)39-26/h2-6,9-11,14,20-22,31H,7-8,12-13,15-17H2,1H3,(H,33,37)(H4,29,30,32) DSRYOPYBUYZKDD-UHFFFAOYSA-N 50052417 (S)-N-((S)-1-(benzo[d]oxazol-2-yl)-5-guanidino-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL105584 Prothrombin Homo sapiens 3.8 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052417&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 11800433 103949293 CHEMBL105584 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776949 C[C@@H]1CCN([C@H](C1)C(O)=O)C(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1cccc2CC(C)CNc12 InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26) KXNPVXPOPUZYGB-UHFFFAOYSA-N 50038001 CHEMBL1166::(2R,4S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::MD-805::1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::1-[(2R,3S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2R,4R)-1-[(S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2S,4S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic acid::DK-7419::MCI-9038::1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid (Argatroban)::GN-1600::(S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::ARGATROBAN Prothrombin Homo sapiens 52 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038001&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 92722 103945452 CHEMBL1166 C04931 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776950 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2o1 InChI=1S/C28H35N7O4/c1-31-21(17-18-9-3-2-4-10-18)27(38)35-16-8-13-22(35)25(37)33-20(12-7-15-32-28(29)30)24(36)26-34-19-11-5-6-14-23(19)39-26/h2-6,9-11,14,20-22,31H,7-8,12-13,15-17H2,1H3,(H,33,37)(H4,29,30,32) DSRYOPYBUYZKDD-UHFFFAOYSA-N 50052417 (S)-N-((S)-1-(benzo[d]oxazol-2-yl)-5-guanidino-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-1-(benzooxazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL105584 Serine protease 1 Bos taurus 2.9 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052417&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 11800433 103949293 CHEMBL105584 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776951 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nccs1 InChI=1S/C24H33N7O3S/c1-27-18(15-16-7-3-2-4-8-16)23(34)31-13-6-10-19(31)21(33)30-17(9-5-11-29-24(25)26)20(32)22-28-12-14-35-22/h2-4,7-8,12,14,17-19,27H,5-6,9-11,13,15H2,1H3,(H,30,33)(H4,25,26,29) GZUGRLHDTNRHQF-UHFFFAOYSA-N 50052418 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-amide::(S)-N-((S)-5-guanidino-1-oxo-1-(thiazol-2-yl)pentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::CHEMBL322205 Serine protease 1 Bos taurus 1.6 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052418&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 10696697 103949294 CHEMBL322205 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776952 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-c1cc2ccccc2s1 |r| InChI=1S/C29H13N6O3S/c1-32-22(17-19-9-3-2-4-10-19)28(38)35-16-8-13-23(35)27(37)34-21(12-7-15-33-29(30)31)26(36)25-18-20-11-5-6-14-24(20)39-25/h2-6,9-11,14,18,21-23H XTASMIYFRGFFDD-UHFFFAOYSA-N 14111 CHEMBL256591::(2S)-N-[(2S)-1-(1-benzothiophen-2-yl)-5-carbamimidamido-1-oxopentan-2-yl]-1-[(2R)-2-(methylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide::2-ketobenzothiazole 51 Serine protease 1 Bos taurus 1340 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14111&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 10602709 46514473 CHEMBL256591 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776953 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1ccccn1 InChI=1S/C26H12N7O3/c1-29-21(17-18-9-3-2-4-10-18)25(36)33-16-8-13-22(33)24(35)32-20(12-7-15-31-26(27)28)23(34)19-11-5-6-14-30-19/h2-6,9-11,14,20-22H CKWNQFZUJNRQEJ-UHFFFAOYSA-N 50228855 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(pyridine-2-carbonyl)-butyl]-amide::(S)-N-((S)-5-guanidino-1-oxo-1-(pyridin-2-yl)pentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::CHEMBL404728 Prothrombin Homo sapiens 85 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228855&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 11799353 104097966 CHEMBL404728 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776954 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1nc2ccccc2n1-[#6] InChI=1S/C29H12N8O3/c1-32-22(18-19-10-4-3-5-11-19)28(40)37-17-9-15-24(37)27(39)35-21(13-8-16-33-29(30)31)25(38)26-34-20-12-6-7-14-23(20)36(26)2/h3-7,10-12,14,21-22,24H KHSRNBLKGKEQEJ-UHFFFAOYSA-N 50228857 (S)-N-((S)-5-guanidino-1-(1-methyl-1H-benzo[d]imidazol-2-yl)-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(1-methyl-1H-benzoimidazole-2-carbonyl)-butyl]-amide::CHEMBL256381 Serine protease 1 Bos taurus 290 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228857&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 10650243 104097968 CHEMBL256381 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776955 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2CCCCc2s1 InChI=1S/C28H39N7O3S/c1-31-21(17-18-9-3-2-4-10-18)27(38)35-16-8-13-22(35)25(37)33-20(12-7-15-32-28(29)30)24(36)26-34-19-11-5-6-14-23(19)39-26/h2-4,9-10,20-22,31H,5-8,11-17H2,1H3,(H,33,37)(H4,29,30,32) PACZQPQCHDGDJM-UHFFFAOYSA-N 50052422 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(4,5,6,7-tetrahydro-benzothiazole-2-carbonyl)-butyl]-amide::(S)-N-((S)-5-guanidino-1-oxo-1-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)pentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::CHEMBL102121 Prothrombin Homo sapiens 3.4 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052422&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 10554762 103949295 CHEMBL102121 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776958 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6]=O InChI=1S/C21H8N6O3/c1-24-17(13-15-7-3-2-4-8-15)20(30)27-12-6-10-18(27)19(29)26-16(14-28)9-5-11-25-21(22)23/h2-4,7-8,16-18H NZEAENHOWXTKPM-UHFFFAOYSA-N 50228863 1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]-1-[2-methylamino-3-phenyl-(2R)-propanoyl]-(5S)-dihydro-1H-5-pyrrolecarboxamide::Me-(D-Phe)-Pro-Arg-CHO::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid ((S)-1-formyl-4-guanidino-butyl)-amide::CHEMBL273196 Prothrombin Homo sapiens 10 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228863&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 122267 104097969 CHEMBL273196 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776959 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2[nH]1 InChI=1S/C28H36N8O3/c1-31-22(17-18-9-3-2-4-10-18)27(39)36-16-8-14-23(36)26(38)35-21(13-7-15-32-28(29)30)24(37)25-33-19-11-5-6-12-20(19)34-25/h2-6,9-12,21-23,31H,7-8,13-17H2,1H3,(H,33,34)(H,35,38)(H4,29,30,32) DPKBODMBRLVNFI-UHFFFAOYSA-N 50052423 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-1-(1H-benzoimidazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL101855 Serine protease 1 Bos taurus 38 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052423&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 10840002 103949296 CHEMBL101855 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776960 CN([C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)C(O)c1nc2ccccc2s1)C(=O)OCc1ccccc1 InChI=1S/C43H49N7O7S2/c1-29-21-23-32(24-22-29)59(55,56)48-42(44)45-25-11-18-34(38(51)40-47-33-17-9-10-20-37(33)58-40)46-39(52)35-19-12-26-50(35)41(53)36(27-30-13-5-3-6-14-30)49(2)43(54)57-28-31-15-7-4-8-16-31/h3-10,13-17,20-24,34-36,38,51H,11-12,18-19,25-28H2,1-2H3,(H,46,52)(H3,44,45,48) XDHZCIYLIIEAJR-UHFFFAOYSA-N 50052424 2-{1-hydroxy-5-imino(4-methylphenylsulfonamido)methylamino-2-[1-(N-methylbenzyloxycarbonyl amino-3-phenylpropanoyl)tetrahydro-1H-2-pyrrolylcarboxamido]pentyl}benzo[d][1,3]thiazole::CHEMBL322444 Prothrombin Homo sapiens 16000 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052424&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 44333803 103949297 CHEMBL322444 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776961 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6]=O InChI=1S/C21H8N6O3/c1-24-17(13-15-7-3-2-4-8-15)20(30)27-12-6-10-18(27)19(29)26-16(14-28)9-5-11-25-21(22)23/h2-4,7-8,16-18H NZEAENHOWXTKPM-UHFFFAOYSA-N 50228863 1-(2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid (1-formyl-4-guanidino-butyl)-amide::5N-[4-amino(imino)methylamino-1-formyl-(1S)-butyl]-1-[2-methylamino-3-phenyl-(2R)-propanoyl]-(5S)-dihydro-1H-5-pyrrolecarboxamide::Me-(D-Phe)-Pro-Arg-CHO::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid ((S)-1-formyl-4-guanidino-butyl)-amide::CHEMBL273196 Serine protease 1 Bos taurus 3.9 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228863 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228863&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 122267 104097969 CHEMBL273196 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776962 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-c1cc2ccccc2s1 |r| InChI=1S/C29H13N6O3S/c1-32-22(17-19-9-3-2-4-10-19)28(38)35-16-8-13-23(35)27(37)34-21(12-7-15-33-29(30)31)26(36)25-18-20-11-5-6-14-24(20)39-25/h2-6,9-11,14,18,21-23H XTASMIYFRGFFDD-UHFFFAOYSA-N 14111 CHEMBL256591::(2S)-N-[(2S)-1-(1-benzothiophen-2-yl)-5-carbamimidamido-1-oxopentan-2-yl]-1-[(2R)-2-(methylamino)-3-phenylpropanoyl]pyrrolidine-2-carboxamide::2-ketobenzothiazole 51 Prothrombin Homo sapiens 2400 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14111&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 10602709 46514473 CHEMBL256591 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776963 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2c(=O)[nH]1 InChI=1S/C29H36N8O4/c1-32-22(17-18-9-3-2-4-10-18)28(41)37-16-8-14-23(37)27(40)35-21(13-7-15-33-29(30)31)24(38)25-34-20-12-6-5-11-19(20)26(39)36-25/h2-6,9-12,21-23,32H,7-8,13-17H2,1H3,(H,35,40)(H4,30,31,33)(H,34,36,39) DSBAJYNIVIRLCB-UHFFFAOYSA-N 50052425 CHEMBL165326::CHEMBL102919::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(4-oxo-4,4a-dihydro-quinazoline-2-carbonyl)-butyl]-amide Serine protease 1 Bos taurus 8.2 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052425&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 10792977 103949298 CHEMBL102919CHEMBL165326 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776964 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1nc2ccccc2s1 InChI=1S/C28H12N7O3S/c1-31-21(17-18-9-3-2-4-10-18)27(38)35-16-8-13-22(35)25(37)33-20(12-7-15-32-28(29)30)24(36)26-34-19-11-5-6-14-23(19)39-26/h2-6,9-11,14,20-22H QCCMGBCCBBJKNN-UHFFFAOYSA-N 50228853 RWJ-50353::(S)-N-((S)-1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL270437 Serine protease 1 Bos taurus 3.1 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228853&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 9872263 104097965 CHEMBL270437 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776965 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1nc2ccccc2n1-[#6] InChI=1S/C29H12N8O3/c1-32-22(18-19-10-4-3-5-11-19)28(40)37-17-9-15-24(37)27(39)35-21(13-8-16-33-29(30)31)25(38)26-34-20-12-6-7-14-23(20)36(26)2/h3-7,10-12,14,21-22,24H KHSRNBLKGKEQEJ-UHFFFAOYSA-N 50228857 (S)-N-((S)-5-guanidino-1-(1-methyl-1H-benzo[d]imidazol-2-yl)-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(1-methyl-1H-benzoimidazole-2-carbonyl)-butyl]-amide::CHEMBL256381 Prothrombin Homo sapiens 8.1 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228857&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 10650243 104097968 CHEMBL256381 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776966 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1nccn1-[#6] InChI=1S/C25H10N8O3/c1-28-19(16-17-8-4-3-5-9-17)24(36)33-14-7-11-20(33)23(35)31-18(10-6-12-30-25(26)27)21(34)22-29-13-15-32(22)2/h3-5,8-9,13,15,18-20H VHRMTAWSTVYBEU-UHFFFAOYSA-N 50228856 (S)-N-((S)-5-guanidino-1-(1-methyl-1H-imidazol-2-yl)-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(1-methyl-1H-imidazole-2-carbonyl)-butyl]-amide::CHEMBL272931 Prothrombin Homo sapiens 50 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228856&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 10625087 104097967 CHEMBL272931 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776967 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1ccccn1 InChI=1S/C26H12N7O3/c1-29-21(17-18-9-3-2-4-10-18)25(36)33-16-8-13-22(33)24(35)32-20(12-7-15-31-26(27)28)23(34)19-11-5-6-14-30-19/h2-6,9-11,14,20-22H CKWNQFZUJNRQEJ-UHFFFAOYSA-N 50228855 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(pyridine-2-carbonyl)-butyl]-amide::(S)-N-((S)-5-guanidino-1-oxo-1-(pyridin-2-yl)pentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::CHEMBL404728 Serine protease 1 Bos taurus 73 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228855&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 11799353 104097966 CHEMBL404728 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776968 CN([C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)C(O)c1nc2ccccc2s1)C(=O)OCc1ccccc1 InChI=1S/C43H49N7O7S2/c1-29-21-23-32(24-22-29)59(55,56)48-42(44)45-25-11-18-34(38(51)40-47-33-17-9-10-20-37(33)58-40)46-39(52)35-19-12-26-50(35)41(53)36(27-30-13-5-3-6-14-30)49(2)43(54)57-28-31-15-7-4-8-16-31/h3-10,13-17,20-24,34-36,38,51H,11-12,18-19,25-28H2,1-2H3,(H,46,52)(H3,44,45,48) XDHZCIYLIIEAJR-UHFFFAOYSA-N 50052427 2-{1-hydroxy-5-imino(4-methylphenylsulfonamido)methylamino-2-[1-(N-methylbenzyloxycarbonyl amino-3-phenylpropanoyl)tetrahydro-1H-2-pyrrolylcarboxamido]pentyl}benzo[d][1,3]thiazole::CHEMBL319615 Prothrombin Homo sapiens 5300 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052427&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 10771811 103949299 CHEMBL319615 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776969 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2[nH]1 InChI=1S/C28H36N8O3/c1-31-22(17-18-9-3-2-4-10-18)27(39)36-16-8-14-23(36)26(38)35-21(13-7-15-32-28(29)30)24(37)25-33-19-11-5-6-12-20(19)34-25/h2-6,9-12,21-23,31H,7-8,13-17H2,1H3,(H,33,34)(H,35,38)(H4,29,30,32) DPKBODMBRLVNFI-UHFFFAOYSA-N 50052423 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-1-(1H-benzoimidazole-2-carbonyl)-4-guanidino-butyl]-amide::CHEMBL101855 Prothrombin Homo sapiens 12 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052423&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 10840002 103949296 CHEMBL101855 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776970 C[C@@H]1CCN([C@H](C1)C(O)=O)C(=O)[C@H](CCCNC(N)=N)NS(=O)(=O)c1cccc2CC(C)CNc12 InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26) KXNPVXPOPUZYGB-UHFFFAOYSA-N 50038001 CHEMBL1166::(2R,4S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::MD-805::1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::1-[(2R,3S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2R,4R)-1-[(S)-5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2S,4S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::(2R,4R)-1-((S)-5-(diaminomethyleneamino)-2-(3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido)pentanoyl)-4-methylpiperidine-2-carboxylic acid::DK-7419::MCI-9038::1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid (Argatroban)::GN-1600::(S)-1-[5-Guanidino-2-(3-methyl-1,2,3,4-tetrahydro-quinoline-8-sulfonylamino)-pentanoyl]-4-methyl-piperidine-2-carboxylic acid::ARGATROBAN Serine protease 1 Bos taurus 2900 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50038001 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50038001&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 92722 103945452 CHEMBL1166 C04931 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776971 CN([C@@H](Cc1ccccc1)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)C(O)c1nc2ccccc2s1)C(=O)OCc1ccccc1 InChI=1S/C43H49N7O7S2/c1-29-21-23-32(24-22-29)59(55,56)48-42(44)45-25-11-18-34(38(51)40-47-33-17-9-10-20-37(33)58-40)46-39(52)35-19-12-26-50(35)41(53)36(27-30-13-5-3-6-14-30)49(2)43(54)57-28-31-15-7-4-8-16-31/h3-10,13-17,20-24,34-36,38,51H,11-12,18-19,25-28H2,1-2H3,(H,46,52)(H3,44,45,48) XDHZCIYLIIEAJR-UHFFFAOYSA-N 50052424 2-{1-hydroxy-5-imino(4-methylphenylsulfonamido)methylamino-2-[1-(N-methylbenzyloxycarbonyl amino-3-phenylpropanoyl)tetrahydro-1H-2-pyrrolylcarboxamido]pentyl}benzo[d][1,3]thiazole::CHEMBL322444 Serine protease 1 Bos taurus >150000 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052424&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 44333803 103949297 CHEMBL322444 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776973 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nccs1 InChI=1S/C24H33N7O3S/c1-27-18(15-16-7-3-2-4-8-16)23(34)31-13-6-10-19(31)21(33)30-17(9-5-11-29-24(25)26)20(32)22-28-12-14-35-22/h2-4,7-8,12,14,17-19,27H,5-6,9-11,13,15H2,1H3,(H,30,33)(H4,25,26,29) GZUGRLHDTNRHQF-UHFFFAOYSA-N 50052418 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-amide::(S)-N-((S)-5-guanidino-1-oxo-1-(thiazol-2-yl)pentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::CHEMBL322205 Prothrombin Homo sapiens 3.6 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052418&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 10696697 103949294 CHEMBL322205 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776974 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2CCCCc2s1 InChI=1S/C28H39N7O3S/c1-31-21(17-18-9-3-2-4-10-18)27(38)35-16-8-13-22(35)25(37)33-20(12-7-15-32-28(29)30)24(36)26-34-19-11-5-6-14-23(19)39-26/h2-4,9-10,20-22,31H,5-8,11-17H2,1H3,(H,33,37)(H4,29,30,32) PACZQPQCHDGDJM-UHFFFAOYSA-N 50052422 (S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(4,5,6,7-tetrahydro-benzothiazole-2-carbonyl)-butyl]-amide::(S)-N-((S)-5-guanidino-1-oxo-1-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)pentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::CHEMBL102121 Serine protease 1 Bos taurus 4.4 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052422&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 10554762 103949295 CHEMBL102121 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776975 CN([C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)NS(=O)(=O)c1ccc(C)cc1)C(O)c1nc2ccccc2s1)C(=O)OCc1ccccc1 InChI=1S/C43H49N7O7S2/c1-29-21-23-32(24-22-29)59(55,56)48-42(44)45-25-11-18-34(38(51)40-47-33-17-9-10-20-37(33)58-40)46-39(52)35-19-12-26-50(35)41(53)36(27-30-13-5-3-6-14-30)49(2)43(54)57-28-31-15-7-4-8-16-31/h3-10,13-17,20-24,34-36,38,51H,11-12,18-19,25-28H2,1-2H3,(H,46,52)(H3,44,45,48) XDHZCIYLIIEAJR-UHFFFAOYSA-N 50052427 2-{1-hydroxy-5-imino(4-methylphenylsulfonamido)methylamino-2-[1-(N-methylbenzyloxycarbonyl amino-3-phenylpropanoyl)tetrahydro-1H-2-pyrrolylcarboxamido]pentyl}benzo[d][1,3]thiazole::CHEMBL319615 Serine protease 1 Bos taurus >150000 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052427&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 10771811 103949299 CHEMBL319615 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3 50776976 CN[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2c(=O)[nH]1 InChI=1S/C29H36N8O4/c1-32-22(17-18-9-3-2-4-10-18)28(41)37-16-8-14-23(37)27(40)35-21(13-7-15-33-29(30)31)24(38)25-34-20-12-6-5-11-19(20)26(39)36-25/h2-6,9-12,21-23,32H,7-8,13-17H2,1H3,(H,35,40)(H4,30,31,33)(H,34,36,39) DSBAJYNIVIRLCB-UHFFFAOYSA-N 50052425 CHEMBL165326::CHEMBL102919::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(4-oxo-4,4a-dihydro-quinazoline-2-carbonyl)-butyl]-amide Prothrombin Homo sapiens 15 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50052425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=334&target=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50052425&enzyme=Prothrombin&column=ki&startPg=0&Increment=50&submit=Search 10792977 103949298 CHEMBL102919CHEMBL165326 1 MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE 9CMO,9CLS,9CLN,8RTN,8UF7,4O03,4NZQ,1XM1,1JWT,1HAG,1DOJ,1NU9,6V5T,2BDY,1D9I,3C1K,1ZRB,1ZGV,1ZGI,1Z71,1TA6,1TA2,1SL3,1NT1,1NM6,1G37,1D6W,9R8Q,9H79,9H5N,9C50,8BW5,8ASF,8ASE,7ZKO,7ZKN,7ZKM,7ZKL,7PHX,7NTU,7MJ5,7KME,7AC9,6ZV8,6ZV7,6ZUX,6ZUW,6ZUU,6ZUN,6ZUH,6ZGO,6Z8X,6Z8W,6Z8V,6Z48,6YSX,6YSJ,6YQV,6YN3,6YMP,6YHJ,6YHG,6YB6,6Y9H,6Y02,6V64,6TKL,6TKJ,6TKI,6TKH,6TKG,6TDT,6T8A,6T89,6T7H,6T57,6T56,6T55,6T54,6T53,6T52,6T4A,6T3Q,6T3M,6I51,6HSX,6GWE,6GN7,6GBW,6EVV,6EO9,6EO8,6EO7,6EO6,6CYM,5NHU,5LPD,5LCE,5L6N,5JZY,5JFD,5GIM,5GDS,5EW2,5EW1,5E8E,5CMX,4YES,4UD9,4THN,4LZ4,4LZ1,4LXB,4I7Y,4HTC,4E7R,4E06,4E05,4DII,4DIH,4CH8,4CH2,4BOH,4BAQ,4BAO,4BAN,4BAM,4BAK,4BAH,3VXF,3VXE,3UWJ,3UTU,3U9A,3U98,3U8T,3U8R,3U8O,3U69,3TU7,3T5F,3SV2,3SI4,3SI3,3SHC,3SHA,3RMO,3RMN,3RMM,3RML,3RM2,3RM0,3RLY,3RLW,3QX5,3QWC,3QTV,3QTO,3QLP,3PMH,3P70,3P6Z,3P17,3LDX,3HTC,3HAT,3F68,3EQ0,3EGK,3E6P,3DUX,3DT0,3DHK,3DA9,3D49,3C27,3BF6,3B23,2ZO3,2ZNK,2ZIQ,2ZI2,2ZHW,2ZHQ,2ZHF,2ZHE,2ZGX,2ZGB,2ZG0,2ZFR,2ZFQ,2ZFP,2ZFF,2ZF0,2ZDV,2ZDA,2ZC9,2UUK,2UUJ,2UUF,2R2M,2JH6,2JH5,2JH0,2HPQ,2HPP,2HGT,2H9T,2GDE,2FES,2FEQ,2C93,2C90,2C8Z,2C8Y,2C8X,2C8W,2BXU,2BXT,2BVX,2BVS,2ANK,2AFQ,2A45,2A2X,1XMN,1WAY,1W7G,1UVS,1UMA,1TOM,1TMU,1TMT,1TMB,1THS,1THR,1TBZ,1T4V,1T4U,1SR5,1QJ7,1QJ6,1QJ1,1QHR,1QBV,1PPB,1P8V,1OYT,1OOK,1O5G,1O2G,1O0D,1NZQ,1NU7,1NRS,1NRR,1NRQ,1NRP,1NRO,1NRN,1NO9,1MUE,1MU8,1MU6,1LHG,1LHF,1LHE,1LHD,1LHC,1KTT,1KTS,1K22,1K21,1IHT,1IHS,1HXF,1HXE,1HUT,1HLT,1HGT,1HDT,1HBT,1HAP,1HAO,1HAI,1HAH,1G32,1G30,1FPH,1FPC,1DWE,1DWD,1DWC,1DWB,1DIT,1DE7,1D4P,1D3T,1D3Q,1D3P,1CA8,1C5O,1C5N,1C5L,1C1W,1C1V,1C1U,1BMN,1BMM,1BCU,1BB0,1BA8,1B5G,1AY6,1AWH,1AWF,1AIX,1AI8,1AHT,1AFE,1AE8,1AD8,1ABJ,1ABI,1A61,1A5G,1A4W,1A46,1A3E,1A3B,1A2C,6PXJ,6ZUG,5DO4,5AHG,5AFZ,5AFY,5AF9,5A2M,4UFG,4UFF,4UFE,4UFD,4UEH,4UE7,4UDW,3DD2,2PW8,1SB1,1GJ5,1GJ4,4LOY,4AZ2,4AYY,4AYV,4AX9,3BIV,3BIU Prothrombin THRB_HUMAN P00734 B2R7F7 B4E1A7 Q4QZ40 Q53H04 Q53H06 Q69EZ7 Q7Z7P3 Q9UCA1 50776977 [#6]-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1nccn1-[#6] InChI=1S/C25H10N8O3/c1-28-19(16-17-8-4-3-5-9-17)24(36)33-14-7-11-20(33)23(35)31-18(10-6-12-30-25(26)27)21(34)22-29-13-15-32(22)2/h3-5,8-9,13,15,18-20H VHRMTAWSTVYBEU-UHFFFAOYSA-N 50228856 (S)-N-((S)-5-guanidino-1-(1-methyl-1H-imidazol-2-yl)-1-oxopentan-2-yl)-1-((R)-2-(methylamino)-3-phenylpropanoyl)pyrrolidine-2-carboxamide::(S)-1-((R)-2-Methylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(S)-4-guanidino-1-(1-methyl-1H-imidazole-2-carbonyl)-butyl]-amide::CHEMBL272931 Serine protease 1 Bos taurus 4400 ChEMBL 10.1021/jm9603274 10.7270/Q24B3208 8759623 Costanzo, MJ; Maryanoff, BE; Hecker, LR; Schott, MR; Yabut, SC; Zhang, HC; Andrade-Gordon, P; Kauffman, JA; Lewis, JM; Krishnan, R; Tulinsky, A 9/24/1996 11/1/2012 R. W. Johnson Pharmaceutical Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50228856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=177&target=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50228856&enzyme=Serine+protease+1&column=ki&startPg=0&Increment=50&submit=Search 10625087 104097967 CHEMBL272931 1 MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 8XNI,6YIS,6YDY,6T9V,6T9U,6T5W,6T0P,6T0M,6SY3,6SWV,6QL0,5JYI,5FXL,4XOJ,4GUX,2BYA,2BY9,2BY8,2BY7,2BY6,2BY5,1UTQ,1UTP,1UTO,1UTN,1LQE,1F0U,1F0T,1EZX,1OPH,1ZZZ,4TPI,3TPI,2TPI,2TGT,2TGP,2TGD,2TGA,1TNL,1TNK,1TNJ,1TNI,1TNH,1TNG,1TGT,1TGS,1TGN,1TGC,1TGB,1BTZ,1BTY,1BTX,1BTW,1BTP,1G3E,1G3D,1G3C,1G3B,9KK5,9KK4,9BOM,9BOK,9AWZ,9AWV,9AWU,9AWS,9AWR,9AWQ,9AWP,9AWO,9AWN,9AWM,9AWL,9AWI,9AWH,9AWG,9AWF,9AWD,9AWC,9AWB,9AWA,9AW9,9AW8,9AW4,9AW2,9AW1,9AW0,9AVZ,9AVY,9AVX,8XNJ,8WK1,8UTL,8UO7,8KDU,8IZK,8IZI,8IZH,8IYV,7Z2I,7Z25,7WBA,7WB9,7WB8,7WB7,7WB6,7WA2,7WA0,7VO7,7Q0X,7Q0W,7PH1,7JWX,7JR2,7JR1,7BSA,7BS9,7BS8,7BS7,7BS6,7BS5,7BS4,7BS3,7BS2,7BS1,7BS0,7BRZ,7BRY,7BRX,7BRW,7BRV,7AYS,7AL8,6ZQ2,6ZFK,6ZFJ,6YZC,6YZA,6YIY,6YIX,6YIW,6YIV,6YIU,6YIT,6XYK,6XYG,6VXY,6U22,6SW0,6SVZ,6SVX,6SVW,6SVV,6SVU,6SVR,6SVN,6SVJ,6SVI,6SVG,6SVD,6SVB,6SV9,6SV8,6SV6,6SV0,6SUX,6QIH,6FID,6EAX,6EAW,6EAV,6EAU,6EAT,6E5M,6DZF,6DWU,6DWH,6DWF,6BVH,6BFP,6B6T,6B6S,6B6R,6B6Q,6B6P,6B6O,6B6N,6AVL,5T3H,5PTP,5MOS,5MOR,5MOQ,5MOP,5MOO,5MON,5MO2,5MO1,5MO0,5MNZ,5MNY,5MNX,5MNQ,5MNP,5MNO,5MNN,5MNM,5MNL,5MNK,5MNH,5MNG,5MNF,5MNE,5MNC,5MNB,5MNA,5MN1,5LH8,5LH4,5LGO,5K7R,5GXP,5GIB,5F6M,5EG4,4YTA,4Y11,4Y10,4Y0Z,4Y0Y,4U2W,4TPY,4NCY,4MTB,4KTU,4KTS,4J2Y,4I8L,4I8K,4I8J,4I8H,4I8G,4HGC,4AOR,4AOQ,4ABJ,4ABI,4ABH,4ABG,4ABF,4ABE,4ABD,4ABB,4ABA,4AB9,4AB8,3VPK,3T29,3T28,3T27,3T26,3T25,3RXV,3RXU,3RXT,3RXS,3RXR,3RXQ,3RXP,3RXO,3RXM,3RXL,3RXK,3RXJ,3RXI,3RXH,3RXG,3RXF,3RXE,3RXD,3RXC,3RXB,3RXA,3RU4,3RDZ,3PTN,3PTB,3OTJ,3NKK,3NK8,3MI4,3MFJ,3M7Q,3M35,3LJO,3LJJ,3ITI,3I29,3GY8,3GY7,3GY6,3GY5,3GY4,3GY3,3GY2,3E8L,3D65,3BTW,3BTT,3BTQ,3BTM,3BTK,3BTH,3BTG,3BTF,3BTE,3BTD,3ATM,3ATL,3ATK,3ATI,3AAV,3AAU,3AAS,3A8D,3A8C,3A8B,3A8A,3A89,3A88,3A87,3A86,3A85,3A84,3A83,3A82,3A81,3A80,3A7Z,3A7Y,3A7X,3A7W,3A7V,3A7T,2ZQ2,2ZQ1,2ZHD,2ZFT,2ZFS,2ZDN,2ZDM,2ZDL,2ZDK,2XTT,2UUY,2TIO,2QYI,2QN5,2PTN,2PTC,2PLX,2OXS,2OTV,2O9Q,2J9N,2ILN,2G8T,2G81,2G5V,2G5N,2G55,2FX6,2FX4,2FI3,2F3C,2D8W,2CMY,2BZA,2BTC,2BLW,2BLV,2AYW,2AH4,2AGI,2AGG,2AGE,2A7H,1YP9,1Y3Y,1Y3X,1Y3W,1Y3V,1Y3U,1XUK,1XUJ,1XUI,1XUH,1XUG,1XUF,1TYN,1TX8,1TX7,1TPS,1TPP,1TPO,1TPA,1TLD,1TIO,1TAB,1SMF,1SFI Serine protease 1 TRY1_BOVIN P00760 A6H6Y3