BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 50778394 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C(F)(F)C(F)(F)F InChI=1S/C16H13F5N2O2/c1-8-6-10(4-5-12(8)15(17,18)16(19,20)21)23-14(25)11(7-22)13(24)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,23,25) YBFIOYANCKDTED-UHFFFAOYSA-N 50054541 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-pentafluoroethyl-phenyl)-acrylamide::CHEMBL139937 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 11 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054541&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929462 103951126 CHEMBL139937 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778395 FC(F)(F)c1csc(n1)-c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C17H12F3N3O2S/c18-17(19,20)13-8-26-16(23-13)10-3-5-11(6-4-10)22-15(25)12(7-21)14(24)9-1-2-9/h3-6,8-9,12H,1-2H2,(H,22,25) VUMSACFELULPDY-UHFFFAOYSA-N 50054546 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-[4-(4-trifluoromethyl-thiazol-2-yl)-phenyl]-acrylamide::CHEMBL143458 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 50000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054546 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054546&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54411558 103951131 CHEMBL143458 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778396 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C18H10F6N2O2/c19-17(20,21)11-3-1-10(2-4-11)15(27)14(9-25)16(28)26-13-7-5-12(6-8-13)18(22,23)24/h1-8,14H,(H,26,28) YDYXPDZIUAYLIH-UHFFFAOYSA-N 50054542 2-Cyano-3-hydroxy-3,N-bis-(4-trifluoromethyl-phenyl)-acrylamide::(Z)-2-Cyano-3-hydroxy-3,N-bis-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL432994 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054542&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15181225 103951127 CHEMBL432994 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778397 COC(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C15H14N2O4/c1-21-15(20)10-4-6-11(7-5-10)17-14(19)12(8-16)13(18)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,17,19) WWWWRPOMRIMGST-UHFFFAOYSA-N 50054545 4-((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-acryloylamino)-benzoic acid methyl ester::CHEMBL139954 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 1120 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054545 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054545&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929463 103951130 CHEMBL139954 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778398 CC(=C)C(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C14H11F3N2O2/c1-8(2)12(20)11(7-18)13(21)19-10-5-3-9(4-6-10)14(15,16)17/h3-6,11H,1H2,2H3,(H,19,21) UFJNSGIBUJADFQ-UHFFFAOYSA-N 50054543 2-cyano-3-hydroxy-4-methyl-N-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide::(Z)-2-Cyano-3-hydroxy-4-methyl-penta-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL141086 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 251 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054543 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054543&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54350498 103951128 CHEMBL141086 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778399 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCCN2)cc1 InChI=1S/C15H14F3N3O2/c16-15(17,18)9-3-5-10(6-4-9)21-14(23)11(8-19)13(22)12-2-1-7-20-12/h3-6,11-12,20H,1-2,7H2,(H,21,23) AVJJSTSKKNYXAA-UHFFFAOYSA-N 50054544 (Z)-2-Cyano-3-hydroxy-3-pyrrolidin-2-yl-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143496 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054544&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53664121 103951129 CHEMBL143496 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778400 CSc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O2S/c1-19-11-6-4-10(5-7-11)16-14(18)12(8-15)13(17)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,16,18) MOXHJPCGLKALOZ-UHFFFAOYSA-N 50054552 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methylsulfanyl-phenyl)-acrylamide::CHEMBL143816 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 445 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054552 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054552&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54083688 103951137 CHEMBL143816 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778401 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O2/c15-14(16,17)9-3-5-10(6-4-9)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) IHKAHKDEGXLVIY-UHFFFAOYSA-N 29024 CHEMBL141732::cyanocyclopropylpropenamide, 4 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 21 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29024&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411780 81054453 CHEMBL141732 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778402 Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O2/c1-9-2-6-11(7-3-9)16-14(18)12(8-15)13(17)10-4-5-10/h2-3,6-7,10,12H,4-5H2,1H3,(H,16,18) YFDCKORXPDAUIO-UHFFFAOYSA-N 50054547 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-p-tolyl-acrylamide::CHEMBL141040 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 234 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054547&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 47275544 103951132 CHEMBL141040 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778403 Brc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C13H11BrN2O2/c14-9-3-5-10(6-4-9)16-13(18)11(7-15)12(17)8-1-2-8/h3-6,8,11H,1-2H2,(H,16,18) WVQOCQNOMMJAIS-UHFFFAOYSA-N 50054548 (Z)-N-(4-Bromo-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL142214 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 79 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054548&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54452109 103951133 CHEMBL142214 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778404 Brc1ccc(NC(=O)C(C#N)C(=O)C2CC2)nc1 InChI=1S/C12H10BrN3O2/c13-8-3-4-10(15-6-8)16-12(18)9(5-14)11(17)7-1-2-7/h3-4,6-7,9H,1-2H2,(H,15,16,18) WGGZCXCSCUXXJL-UHFFFAOYSA-N 50054549 (Z)-N-(5-Bromo-pyridin-2-yl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143237 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 158 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054549 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054549&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54429189 103951134 CHEMBL143237 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778405 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCC2)cc1 InChI=1S/C15H13F3N2O2/c16-15(17,18)10-4-6-11(7-5-10)20-14(22)12(8-19)13(21)9-2-1-3-9/h4-7,9,12H,1-3H2,(H,20,22) QMMHCNUCDZDPBA-UHFFFAOYSA-N 50054550 (Z)-2-Cyano-3-cyclobutyl-3-hydroxy-N-(4-trifluoromethyl-phenyl)-acrylamide::2-cyano-3-cyclobutyl-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide::CHEMBL337130 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 282 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054550 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054550&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411782 103951135 CHEMBL337130 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778406 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCOC2)cc1 InChI=1S/C15H13F3N2O3/c16-15(17,18)10-1-3-11(4-2-10)20-14(22)12(7-19)13(21)9-5-6-23-8-9/h1-4,9,12H,5-6,8H2,(H,20,22) QRECZZCVBQCIIJ-UHFFFAOYSA-N 50054551 (Z)-2-Cyano-3-hydroxy-3-(tetrahydro-furan-3-yl)-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143291 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 11700 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054551 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054551&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929464 103951136 CHEMBL143291 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778407 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C#N InChI=1S/C15H13N3O2/c1-9-6-12(5-4-11(9)7-16)18-15(20)13(8-17)14(19)10-2-3-10/h4-6,10,13H,2-3H2,1H3,(H,18,20) ROBREFIKRIXVSQ-UHFFFAOYSA-N 50054553 (Z)-2-Cyano-N-(4-cyano-3-methyl-phenyl)-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL358411 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 28 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054553 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054553&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411791 103951138 CHEMBL358411 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778408 Clc1ccc(cc1)C(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C20H15ClN2O3/c21-15-7-3-12(4-8-15)18(24)13-5-9-16(10-6-13)23-20(26)17(11-22)19(25)14-1-2-14/h3-10,14,17H,1-2H2,(H,23,26) VMPYCTXJHYSIRH-UHFFFAOYSA-N 50054554 (Z)-N-[4-(4-Chloro-benzoyl)-phenyl]-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143196 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 562 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054554 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054554&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54399848 103951139 CHEMBL143196 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778409 Clc1ccc(NC(=O)C(C#N)C(=O)C2CC2)nc1 InChI=1S/C12H10ClN3O2/c13-8-3-4-10(15-6-8)16-12(18)9(5-14)11(17)7-1-2-7/h3-4,6-7,9H,1-2H2,(H,15,16,18) GEZLOUZTMXEWHQ-UHFFFAOYSA-N 50054555 (Z)-N-(5-Chloro-pyridin-2-yl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143052 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 76 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054555&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53834914 103951140 CHEMBL143052 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778410 [O-][N+](=O)c1ccc(NC(=O)C(=C=[N-])C(=[OH+])C2CC2)cc1 InChI=1S/C13H10N3O4/c14-7-11(12(17)8-1-2-8)13(18)15-9-3-5-10(6-4-9)16(19)20/h3-6,8H,1-2H2,(H,15,18)/q-1/p+1 QHPPLTUFMYEUSN-UHFFFAOYSA-O 50054557 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-nitro-phenyl)-acrylamide::CHEMBL344556 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 50 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054557 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054557&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54680416 103951142 CHEMBL344556 C02125 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778411 FC(F)(F)Oc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O3/c15-14(16,17)22-10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) ICIPZHFRARCJFV-UHFFFAOYSA-N 50054556 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethoxy-phenyl)-acrylamide::CHEMBL344913 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 5 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054556 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054556&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411785 103951141 CHEMBL344913 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778412 Clc1ccc(Oc2ccc(NC(=O)C(C#N)C(=O)C3CC3)cc2)cc1 InChI=1S/C19H15ClN2O3/c20-13-3-7-15(8-4-13)25-16-9-5-14(6-10-16)22-19(24)17(11-21)18(23)12-1-2-12/h3-10,12,17H,1-2H2,(H,22,24) ZECMMNOVVURPKS-UHFFFAOYSA-N 50054561 (Z)-N-[4-(4-Chloro-phenoxy)-phenyl]-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL141237 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 1510 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054561 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054561&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54542338 103951146 CHEMBL141237 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778413 Clc1cccc(NC(=O)C(C#N)C(=O)C2CC2)c1 InChI=1S/C13H11ClN2O2/c14-9-2-1-3-10(6-9)16-13(18)11(7-15)12(17)8-4-5-8/h1-3,6,8,11H,4-5H2,(H,16,18) JYRIARPHFUETPV-UHFFFAOYSA-N 50054558 (Z)-N-(3-Chloro-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL141015 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 343 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054558&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411781 103951143 CHEMBL141015 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778414 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C(F)(F)F InChI=1S/C15H13F3N2O2/c1-8-6-10(4-5-12(8)15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,20,22) WBGXUEJYGSBWMY-UHFFFAOYSA-N 50054560 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-trifluoromethyl-phenyl)-acrylamide::Laflunimus::CHEMBL142218 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 55 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054560 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054560&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 9796698 103951145 CHEMBL142218 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778415 Clc1ccccc1NC(=O)C(C#N)C(=O)C1CC1 InChI=1S/C13H11ClN2O2/c14-10-3-1-2-4-11(10)16-13(18)9(7-15)12(17)8-5-6-8/h1-4,8-9H,5-6H2,(H,16,18) CGUHBOWSZDTILG-UHFFFAOYSA-N 50054559 (Z)-N-(2-Chloro-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL337546 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 16600 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054559 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054559&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 47275719 103951144 CHEMBL337546 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778416 Clc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cn1 InChI=1S/C12H10ClN3O2/c13-10-4-3-8(6-15-10)16-12(18)9(5-14)11(17)7-1-2-7/h3-4,6-7,9H,1-2H2,(H,16,18) YVXBMLOHLRSOHI-UHFFFAOYSA-N 50054562 (Z)-N-(6-Chloro-pyridin-3-yl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL142705 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 630 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054562 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054562&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54530089 103951147 CHEMBL142705 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778417 CC=CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |w:1.0| InChI=1S/C14H11F3N2O2/c1-2-3-12(20)11(8-18)13(21)19-10-6-4-9(5-7-10)14(15,16)17/h2-7,11H,1H3,(H,19,21) YWNKCKQRBLHMNC-UHFFFAOYSA-N 50054565 CHEMBL141472::CHEMBL344613::(2Z,4E)-2-Cyano-3-hydroxy-hexa-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 4270 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054565&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929465 103951150 CHEMBL344613CHEMBL141472 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778418 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCOC2)cc1 InChI=1S/C15H13F3N2O3/c16-15(17,18)10-1-3-11(4-2-10)20-14(22)12(7-19)13(21)9-5-6-23-8-9/h1-4,9,12H,5-6,8H2,(H,20,22) QRECZZCVBQCIIJ-UHFFFAOYSA-N 50054551 (Z)-2-Cyano-3-hydroxy-3-(tetrahydro-furan-3-yl)-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143291 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 11800 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054551 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054551&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929464 103951136 CHEMBL143291 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778419 O=C(Nc1ccc(Oc2ccccc2)cc1)C(C#N)C(=O)C1CC1 InChI=1S/C19H16N2O3/c20-12-17(18(22)13-6-7-13)19(23)21-14-8-10-16(11-9-14)24-15-4-2-1-3-5-15/h1-5,8-11,13,17H,6-7H2,(H,21,23) VNDZFXQSHCNXEU-UHFFFAOYSA-N 50054563 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-phenoxy-phenyl)-acrylamide::CHEMBL141126 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 290 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054563&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54400614 103951148 CHEMBL141126 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778420 CCc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C(F)(F)F InChI=1S/C16H15F3N2O2/c1-2-9-7-11(5-6-13(9)16(17,18)19)21-15(23)12(8-20)14(22)10-3-4-10/h5-7,10,12H,2-4H2,1H3,(H,21,23) XGLWOJFNZFWUOW-UHFFFAOYSA-N 50054564 (Z)-2-Cyano-3-cyclopropyl-N-(3-ethyl-4-trifluoromethyl-phenyl)-3-hydroxy-acrylamide::CHEMBL357459 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 71 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054564 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054564&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54468235 103951149 CHEMBL357459 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778421 O=C(Nc1ccc(cc1)-c1ncco1)C(C#N)C(=O)C1CC1 InChI=1S/C16H13N3O3/c17-9-13(14(20)10-1-2-10)15(21)19-12-5-3-11(4-6-12)16-18-7-8-22-16/h3-8,10,13H,1-2H2,(H,19,21) DEYMKOPHPRXMET-UHFFFAOYSA-N 50054567 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-oxazol-2-yl-phenyl)-acrylamide::CHEMBL342124 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 4270 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054567 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054567&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53756670 103951152 CHEMBL342124 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778422 O=C(Nc1ccccc1)C(C#N)C(=O)C1CC1 InChI=1S/C13H12N2O2/c14-8-11(12(16)9-6-7-9)13(17)15-10-4-2-1-3-5-10/h1-5,9,11H,6-7H2,(H,15,17) UNRSQHSAEAPJRT-UHFFFAOYSA-N 50054569 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-phenyl-acrylamide::CHEMBL141041 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 2000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054569&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 47275637 103951154 CHEMBL141041 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778423 CN1CCCC1C(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C16H16F3N3O2/c1-22-8-2-3-13(22)14(23)12(9-20)15(24)21-11-6-4-10(5-7-11)16(17,18)19/h4-7,12-13H,2-3,8H2,1H3,(H,21,24) USCQNAKKBRTMAX-UHFFFAOYSA-N 50054566 (Z)-2-Cyano-3-hydroxy-3-(1-methyl-pyrrolidin-2-yl)-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143756 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054566&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54369451 103951151 CHEMBL143756 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778424 O=C(Nc1ccc(cc1)-c1ccco1)C(C#N)C(=O)C1CC1 InChI=1S/C17H14N2O3/c18-10-14(16(20)12-3-4-12)17(21)19-13-7-5-11(6-8-13)15-2-1-9-22-15/h1-2,5-9,12,14H,3-4H2,(H,19,21) MDFZKERGJWPYSZ-UHFFFAOYSA-N 50054568 (Z)-2-Cyano-3-cyclopropyl-N-(4-furan-2-yl-phenyl)-3-hydroxy-acrylamide::CHEMBL139611 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 5900 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054568&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54066321 103951153 CHEMBL139611 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778425 Fc1ccc(cc1)-c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C19H15FN2O2/c20-15-7-3-12(4-8-15)13-5-9-16(10-6-13)22-19(24)17(11-21)18(23)14-1-2-14/h3-10,14,17H,1-2H2,(H,22,24) IDAZDOYFJQLVHJ-UHFFFAOYSA-N 50054570 (Z)-2-Cyano-3-cyclopropyl-N-(4'-fluoro-biphenyl-4-yl)-3-hydroxy-acrylamide::CHEMBL142997 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 2140 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054570&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53909919 103951155 CHEMBL142997 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778426 Clc1ccc(cc1)C#Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C21H15ClN2O2/c22-17-9-3-14(4-10-17)1-2-15-5-11-18(12-6-15)24-21(26)19(13-23)20(25)16-7-8-16/h3-6,9-12,16,19H,7-8H2,(H,24,26) LKRKCGWQWTYKLX-UHFFFAOYSA-N 50054571 (Z)-N-[4-(4-Chloro-phenylethynyl)-phenyl]-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL139699 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 5000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054571&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54038524 103951156 CHEMBL139699 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778427 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCC2)cc1 InChI=1S/C15H13F3N2O2/c16-15(17,18)10-4-6-11(7-5-10)20-14(22)12(8-19)13(21)9-2-1-3-9/h4-7,9,12H,1-3H2,(H,20,22) QMMHCNUCDZDPBA-UHFFFAOYSA-N 50054550 (Z)-2-Cyano-3-cyclobutyl-3-hydroxy-N-(4-trifluoromethyl-phenyl)-acrylamide::2-cyano-3-cyclobutyl-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide::CHEMBL337130 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 209 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054550 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054550&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411782 103951135 CHEMBL337130 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778428 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCCN2)cc1 InChI=1S/C15H14F3N3O2/c16-15(17,18)9-3-5-10(6-4-9)21-14(23)11(8-19)13(22)12-2-1-7-20-12/h3-6,11-12,20H,1-2,7H2,(H,21,23) AVJJSTSKKNYXAA-UHFFFAOYSA-N 50054544 (Z)-2-Cyano-3-hydroxy-3-pyrrolidin-2-yl-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143496 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054544&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53664121 103951129 CHEMBL143496 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778429 Fc1ccc(cc1)-c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C19H15FN2O2/c20-15-7-3-12(4-8-15)13-5-9-16(10-6-13)22-19(24)17(11-21)18(23)14-1-2-14/h3-10,14,17H,1-2H2,(H,22,24) IDAZDOYFJQLVHJ-UHFFFAOYSA-N 50054570 (Z)-2-Cyano-3-cyclopropyl-N-(4'-fluoro-biphenyl-4-yl)-3-hydroxy-acrylamide::CHEMBL142997 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 8510 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054570&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53909919 103951155 CHEMBL142997 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778430 Clc1ccc(cc1)C(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C20H15ClN2O3/c21-15-7-3-12(4-8-15)18(24)13-5-9-16(10-6-13)23-20(26)17(11-22)19(25)14-1-2-14/h3-10,14,17H,1-2H2,(H,23,26) VMPYCTXJHYSIRH-UHFFFAOYSA-N 50054554 (Z)-N-[4-(4-Chloro-benzoyl)-phenyl]-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143196 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 590 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054554 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054554&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54399848 103951139 CHEMBL143196 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778431 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C(F)(F)C(F)(F)F InChI=1S/C16H13F5N2O2/c1-8-6-10(4-5-12(8)15(17,18)16(19,20)21)23-14(25)11(7-22)13(24)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,23,25) YBFIOYANCKDTED-UHFFFAOYSA-N 50054541 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-pentafluoroethyl-phenyl)-acrylamide::CHEMBL139937 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 282 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054541&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929462 103951126 CHEMBL139937 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778432 O=C(Nc1ccc(cc1)-c1ccccc1)C(C#N)C(=O)C1CC1 InChI=1S/C19H16N2O2/c20-12-17(18(22)15-6-7-15)19(23)21-16-10-8-14(9-11-16)13-4-2-1-3-5-13/h1-5,8-11,15,17H,6-7H2,(H,21,23) DIIHYLMEQKHUBY-UHFFFAOYSA-N 29026 CHEMBL142996::cyanocyclopropylpropenamide, 11 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 1580 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29026&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53761678 81054455 CHEMBL142996 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778433 FC(F)(F)Sc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O2S/c15-14(16,17)22-10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) NYPCOHOWTLQKKY-UHFFFAOYSA-N 50054573 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethylsulfanyl-phenyl)-acrylamide::CHEMBL141248 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 5 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054573&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54137250 103951158 CHEMBL141248 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778434 CC=CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |w:1.0| InChI=1S/C14H11F3N2O2/c1-2-3-12(20)11(8-18)13(21)19-10-6-4-9(5-7-10)14(15,16)17/h2-7,11H,1H3,(H,19,21) YWNKCKQRBLHMNC-UHFFFAOYSA-N 50054565 CHEMBL141472::CHEMBL344613::(2Z,4E)-2-Cyano-3-hydroxy-hexa-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 107 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054565&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929465 103951150 CHEMBL344613CHEMBL141472 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778435 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1OC(F)(F)F InChI=1S/C15H13F3N2O3/c1-8-6-10(4-5-12(8)23-15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,20,22) WPNXQQAFDXHIMB-UHFFFAOYSA-N 50054574 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-trifluoromethoxy-phenyl)-acrylamide::CHEMBL141774 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 18 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054574&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929466 103951159 CHEMBL141774 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778437 O=C(Nc1ccncc1)C(C#N)C(=O)C1CC1 InChI=1S/C12H11N3O2/c13-7-10(11(16)8-1-2-8)12(17)15-9-3-5-14-6-4-9/h3-6,8,10H,1-2H2,(H,14,15,17) NDRKRVMCYBMMIG-UHFFFAOYSA-N 50054575 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-pyridin-4-yl-acrylamide::CHEMBL342581 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 8910 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054575&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54105817 103951160 CHEMBL342581 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778438 O=C(Nc1ccc(Oc2ccccc2)cc1)C(C#N)C(=O)C1CC1 InChI=1S/C19H16N2O3/c20-12-17(18(22)13-6-7-13)19(23)21-14-8-10-16(11-9-14)24-15-4-2-1-3-5-15/h1-5,8-11,13,17H,6-7H2,(H,21,23) VNDZFXQSHCNXEU-UHFFFAOYSA-N 50054563 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-phenoxy-phenyl)-acrylamide::CHEMBL141126 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 630 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054563&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54400614 103951148 CHEMBL141126 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778439 FC(F)(F)c1ccccc1NC(=O)C(C#N)C(=O)C1CC1 InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-2-4-11(10)19-13(21)9(7-18)12(20)8-5-6-8/h1-4,8-9H,5-6H2,(H,19,21) INRRYKXWZBFZOV-UHFFFAOYSA-N 50054577 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(2-trifluoromethyl-phenyl)-acrylamide::CHEMBL141144 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054577&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53925793 103951162 CHEMBL141144 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778440 FC(F)(F)S(=O)(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O4S/c15-14(16,17)24(22,23)10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) HQBMIRGHILAZRB-UHFFFAOYSA-N 50054585 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethanesulfonyl-phenyl)-acrylamide::CHEMBL356115 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 3 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054585&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53890361 103951170 CHEMBL356115 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778441 Clc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C13H11ClN2O2/c14-9-3-5-10(6-4-9)16-13(18)11(7-15)12(17)8-1-2-8/h3-6,8,11H,1-2H2,(H,16,18) GWQBPNMINIQDPJ-UHFFFAOYSA-N 50054584 (Z)-N-(4-Chloro-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143518 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 63 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054584&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53861275 103951169 CHEMBL143518 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778442 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1Br InChI=1S/C14H13BrN2O2/c1-8-6-10(4-5-12(8)15)17-14(19)11(7-16)13(18)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,17,19) ZBTPMAOXETUWRQ-UHFFFAOYSA-N 50054578 (Z)-N-(4-Bromo-3-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL142074 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 50 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054578&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411786 103951163 CHEMBL142074 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778443 CS(=O)(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O4S/c1-21(19,20)11-6-4-10(5-7-11)16-14(18)12(8-15)13(17)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,16,18) ZLWSVMUKRFWPQW-UHFFFAOYSA-N 50054579 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methanesulfonyl-phenyl)-acrylamide::CHEMBL143460 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 158 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054579&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54553996 103951164 CHEMBL143460 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778444 FC(F)(F)S(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O3S/c15-14(16,17)23(22)10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) HWZMCOGRZDFBES-UHFFFAOYSA-N 50054581 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethanesulfinyl-phenyl)-acrylamide::CHEMBL358621 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 417 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054581&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53900833 103951166 CHEMBL358621 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778445 Oc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C13H12N2O3/c14-7-11(12(17)8-1-2-8)13(18)15-9-3-5-10(16)6-4-9/h3-6,8,11,16H,1-2H2,(H,15,18) GOUFPFWHXUHOKP-UHFFFAOYSA-N 50054582 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-hydroxy-phenyl)-acrylamide::CHEMBL442489 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 7940 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054582&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53849519 103951167 CHEMBL442489 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778446 OC(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H12N2O4/c15-7-11(12(17)8-1-2-8)13(18)16-10-5-3-9(4-6-10)14(19)20/h3-6,8,11H,1-2H2,(H,16,18)(H,19,20) VEPASHCQHSSWMJ-UHFFFAOYSA-N 50054583 4-((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-acryloylamino)-benzoic acid::CHEMBL344405 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 1480 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054583&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54387942 103951168 CHEMBL344405 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778447 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCCC2)cc1 InChI=1S/C16H15F3N2O2/c17-16(18,19)11-5-7-12(8-6-11)21-15(23)13(9-20)14(22)10-3-1-2-4-10/h5-8,10,13H,1-4H2,(H,21,23) QGLCNGHFYRTBAV-UHFFFAOYSA-N 50054580 2-cyano-3-cyclopentyl-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide::(Z)-2-Cyano-3-cyclopentyl-3-hydroxy-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143438 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 31600 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054580&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411783 103951165 CHEMBL143438 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778448 O=C(Nc1ccc(cc1)C#N)C(C#N)C(=O)C1CC1 InChI=1S/C14H11N3O2/c15-7-9-1-5-11(6-2-9)17-14(19)12(8-16)13(18)10-3-4-10/h1-2,5-6,10,12H,3-4H2,(H,17,19) GSSLQBZZKKOMAF-UHFFFAOYSA-N 50054587 Alpha-cyano-beta-hydroxy enamide, 6::CHEMBL141195::(Z)-2-Cyano-N-(4-cyano-phenyl)-3-cyclopropyl-3-hydroxy-acrylamide Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 53 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054587&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 10198927 103951172 CHEMBL141195 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778449 Clc1ccc(\C=C\c2ccc(NC(=O)C(C#N)C(=O)C3CC3)cc2)cc1 InChI=1S/C21H17ClN2O2/c22-17-9-3-14(4-10-17)1-2-15-5-11-18(12-6-15)24-21(26)19(13-23)20(25)16-7-8-16/h1-6,9-12,16,19H,7-8H2,(H,24,26) JRIYWFQBQWRXJN-UHFFFAOYSA-N 50054576 (Z)-N-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenyl}-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL538406 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 12600 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054576&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929467 103951161 CHEMBL538406 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778450 Oc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C13H12N2O3/c14-7-11(12(17)8-1-2-8)13(18)15-9-3-5-10(16)6-4-9/h3-6,8,11,16H,1-2H2,(H,15,18) GOUFPFWHXUHOKP-UHFFFAOYSA-N 50054582 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-hydroxy-phenyl)-acrylamide::CHEMBL442489 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054582&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53849519 103951167 CHEMBL442489 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778451 CC=CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |w:1.0| InChI=1S/C14H11F3N2O2/c1-2-3-12(20)11(8-18)13(21)19-10-6-4-9(5-7-10)14(15,16)17/h2-7,11H,1H3,(H,19,21) YWNKCKQRBLHMNC-UHFFFAOYSA-N 50054565 CHEMBL141472::CHEMBL344613::(2Z,4E)-2-Cyano-3-hydroxy-hexa-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 63 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054565&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929465 103951150 CHEMBL344613CHEMBL141472 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778452 COc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O3/c1-19-11-6-4-10(5-7-11)16-14(18)12(8-15)13(17)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,16,18) QAGAJTLRUNEZSQ-UHFFFAOYSA-N 50054586 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methoxy-phenyl)-acrylamide::CHEMBL334922 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 186 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054586&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 47276705 103951171 CHEMBL334922 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778453 CS(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O3S/c1-20(19)11-6-4-10(5-7-11)16-14(18)12(8-15)13(17)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,16,18) HODJUNLDOQWOKF-UHFFFAOYSA-N 50054588 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methanesulfinyl-phenyl)-acrylamide::CHEMBL357498 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 22400 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054588&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53887442 103951173 CHEMBL357498 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778454 Clc1ccccc1NC(=O)C(C#N)C(=O)C1CC1 InChI=1S/C13H11ClN2O2/c14-10-3-1-2-4-11(10)16-13(18)9(7-15)12(17)8-5-6-8/h1-4,8-9H,5-6H2,(H,16,18) CGUHBOWSZDTILG-UHFFFAOYSA-N 50054559 (Z)-N-(2-Chloro-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL337546 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 13300 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054559 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054559&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 47275719 103951144 CHEMBL337546 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778455 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O2/c15-14(16,17)9-3-5-10(6-4-9)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) IHKAHKDEGXLVIY-UHFFFAOYSA-N 29024 CHEMBL141732::cyanocyclopropylpropenamide, 4 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 47 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29024 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29024&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411780 81054453 CHEMBL141732 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778456 Clc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cn1 InChI=1S/C12H10ClN3O2/c13-10-4-3-8(6-15-10)16-12(18)9(5-14)11(17)7-1-2-7/h3-4,6-7,9H,1-2H2,(H,16,18) YVXBMLOHLRSOHI-UHFFFAOYSA-N 50054562 (Z)-N-(6-Chloro-pyridin-3-yl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL142705 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 1780 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054562 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054562&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54530089 103951147 CHEMBL142705 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778457 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C#N InChI=1S/C15H13N3O2/c1-9-6-12(5-4-11(9)7-16)18-15(20)13(8-17)14(19)10-2-3-10/h4-6,10,13H,2-3H2,1H3,(H,18,20) ROBREFIKRIXVSQ-UHFFFAOYSA-N 50054553 (Z)-2-Cyano-N-(4-cyano-3-methyl-phenyl)-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL358411 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 36 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054553 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054553&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411791 103951138 CHEMBL358411 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778458 O=C(Nc1ccc(CCc2ccccc2)cc1)C(C#N)C(=O)C1CC1 InChI=1S/C21H20N2O2/c22-14-19(20(24)17-10-11-17)21(25)23-18-12-8-16(9-13-18)7-6-15-4-2-1-3-5-15/h1-5,8-9,12-13,17,19H,6-7,10-11H2,(H,23,25) BCOCOCYSHNXUEM-UHFFFAOYSA-N 50054589 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-phenethyl-phenyl)-acrylamide::CHEMBL139647 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 138 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054589&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53675019 103951174 CHEMBL139647 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778459 Clc1ccc(NC(=O)C(C#N)C(=O)C2CC2)nc1 InChI=1S/C12H10ClN3O2/c13-8-3-4-10(15-6-8)16-12(18)9(5-14)11(17)7-1-2-7/h3-4,6-7,9H,1-2H2,(H,15,16,18) GEZLOUZTMXEWHQ-UHFFFAOYSA-N 50054555 (Z)-N-(5-Chloro-pyridin-2-yl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143052 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 200 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054555&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53834914 103951140 CHEMBL143052 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778460 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1SC(F)(F)F InChI=1S/C15H13F3N2O2S/c1-8-6-10(4-5-12(8)23-15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,20,22) VFCOPEZQGPYPNI-UHFFFAOYSA-N 50054590 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-trifluoromethylsulfanyl-phenyl)-acrylamide::CHEMBL343081 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 11 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054590&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929468 103951175 CHEMBL343081 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778463 Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1Cl InChI=1S/C14H13ClN2O2/c1-8-2-5-10(6-12(8)15)17-14(19)11(7-16)13(18)9-3-4-9/h2,5-6,9,11H,3-4H2,1H3,(H,17,19) MBVWUNQMPJDNBR-UHFFFAOYSA-N 50054591 (Z)-N-(3-Chloro-4-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL141104 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 79 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054591&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54064273 103951176 CHEMBL141104 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778464 Nc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C13H13N3O2/c14-7-11(12(17)8-1-2-8)13(18)16-10-5-3-9(15)4-6-10/h3-6,8,11H,1-2,15H2,(H,16,18) NODUWQXSBBXOBD-UHFFFAOYSA-N 50054592 (Z)-N-(4-Amino-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide; hydrochloride::CHEMBL543919 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 31600 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054592&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 89167333 103951177 CHEMBL543919 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778465 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1Br InChI=1S/C14H13BrN2O2/c1-8-6-10(4-5-12(8)15)17-14(19)11(7-16)13(18)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,17,19) ZBTPMAOXETUWRQ-UHFFFAOYSA-N 50054578 (Z)-N-(4-Bromo-3-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL142074 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 63 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054578&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411786 103951163 CHEMBL142074 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778466 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C18H10F6N2O2/c19-17(20,21)11-3-1-10(2-4-11)15(27)14(9-25)16(28)26-13-7-5-12(6-8-13)18(22,23)24/h1-8,14H,(H,26,28) YDYXPDZIUAYLIH-UHFFFAOYSA-N 50054542 2-Cyano-3-hydroxy-3,N-bis-(4-trifluoromethyl-phenyl)-acrylamide::(Z)-2-Cyano-3-hydroxy-3,N-bis-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL432994 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054542&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15181225 103951127 CHEMBL432994 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778467 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1Cl InChI=1S/C14H13ClN2O2/c1-8-6-10(4-5-12(8)15)17-14(19)11(7-16)13(18)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,17,19) KHAVGEAARJAKNI-UHFFFAOYSA-N 50054594 (Z)-N-(4-Chloro-3-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143116 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 40 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054594&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53994371 103951179 CHEMBL143116 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778468 O=C(Nc1ccc(CC#N)cc1)C(C#N)C(=O)C1CC1 InChI=1S/C15H13N3O2/c16-8-7-10-1-5-12(6-2-10)18-15(20)13(9-17)14(19)11-3-4-11/h1-2,5-6,11,13H,3-4,7H2,(H,18,20) CNIGWACYSJNCRP-UHFFFAOYSA-N 50054595 (Z)-2-Cyano-N-(4-cyanomethyl-phenyl)-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL140210 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 4570 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054595&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929469 103951180 CHEMBL140210 C04116 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778469 COc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O3/c1-19-11-6-4-10(5-7-11)16-14(18)12(8-15)13(17)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,16,18) QAGAJTLRUNEZSQ-UHFFFAOYSA-N 50054586 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methoxy-phenyl)-acrylamide::CHEMBL334922 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 3720 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054586&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 47276705 103951171 CHEMBL334922 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778470 OC(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H12N2O4/c15-7-11(12(17)8-1-2-8)13(18)16-10-5-3-9(4-6-10)14(19)20/h3-6,8,11H,1-2H2,(H,16,18)(H,19,20) VEPASHCQHSSWMJ-UHFFFAOYSA-N 50054583 4-((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-acryloylamino)-benzoic acid::CHEMBL344405 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 3720 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054583&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54387942 103951168 CHEMBL344405 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778471 CN(C(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1)c1ccc(Cl)cc1 InChI=1S/C21H18ClN3O3/c1-25(17-10-6-15(22)7-11-17)21(28)14-4-8-16(9-5-14)24-20(27)18(12-23)19(26)13-2-3-13/h4-11,13,18H,2-3H2,1H3,(H,24,27) HOGHBEHZKOTCLX-UHFFFAOYSA-N 50054598 N-(4-Chloro-phenyl)-4-((Z)-2-cyano-3-cyclopropyl-3-hydroxy-acryloylamino)-N-methyl-benzamide::CHEMBL341721 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 2240 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054598&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53887615 103951183 CHEMBL341721 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778472 CS(=O)(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O4S/c1-21(19,20)11-6-4-10(5-7-11)16-14(18)12(8-15)13(17)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,16,18) ZLWSVMUKRFWPQW-UHFFFAOYSA-N 50054579 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methanesulfonyl-phenyl)-acrylamide::CHEMBL143460 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 15100 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054579&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54553996 103951164 CHEMBL143460 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778473 FC(F)(F)S(=O)(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O4S/c15-14(16,17)24(22,23)10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) HQBMIRGHILAZRB-UHFFFAOYSA-N 50054585 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethanesulfonyl-phenyl)-acrylamide::CHEMBL356115 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 89 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054585&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53890361 103951170 CHEMBL356115 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778474 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C(F)(F)F InChI=1S/C15H13F3N2O2/c1-8-6-10(4-5-12(8)15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,20,22) WBGXUEJYGSBWMY-UHFFFAOYSA-N 50054560 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-trifluoromethyl-phenyl)-acrylamide::Laflunimus::CHEMBL142218 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 14 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054560 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054560&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 9796698 103951145 CHEMBL142218 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778475 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1Cl InChI=1S/C14H13ClN2O2/c1-8-6-10(4-5-12(8)15)17-14(19)11(7-16)13(18)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,17,19) KHAVGEAARJAKNI-UHFFFAOYSA-N 50054594 (Z)-N-(4-Chloro-3-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143116 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 33 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054594&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53994371 103951179 CHEMBL143116 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778476 Brc1ccc(NC(=O)C(C#N)C(=O)C2CC2)nc1 InChI=1S/C12H10BrN3O2/c13-8-3-4-10(15-6-8)16-12(18)9(5-14)11(17)7-1-2-7/h3-4,6-7,9H,1-2H2,(H,15,16,18) WGGZCXCSCUXXJL-UHFFFAOYSA-N 50054549 (Z)-N-(5-Bromo-pyridin-2-yl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143237 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 37 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054549 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054549&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54429189 103951134 CHEMBL143237 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778477 COC(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C15H14N2O4/c1-21-15(20)10-4-6-11(7-5-10)17-14(19)12(8-16)13(18)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,17,19) WWWWRPOMRIMGST-UHFFFAOYSA-N 50054545 4-((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-acryloylamino)-benzoic acid methyl ester::CHEMBL139954 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 158 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054545 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054545&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929463 103951130 CHEMBL139954 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778478 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCCO2)cc1 InChI=1S/C15H13F3N2O3/c16-15(17,18)9-3-5-10(6-4-9)20-14(22)11(8-19)13(21)12-2-1-7-23-12/h3-6,11-12H,1-2,7H2,(H,20,22) NQMSXJSQEWSJAD-UHFFFAOYSA-N 50054593 (Z)-2-Cyano-3-hydroxy-3-(tetrahydro-furan-2-yl)-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143437 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 7940 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054593&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54125261 103951178 CHEMBL143437 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778479 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCCO2)cc1 InChI=1S/C15H13F3N2O3/c16-15(17,18)9-3-5-10(6-4-9)20-14(22)11(8-19)13(21)12-2-1-7-23-12/h3-6,11-12H,1-2,7H2,(H,20,22) NQMSXJSQEWSJAD-UHFFFAOYSA-N 50054593 (Z)-2-Cyano-3-hydroxy-3-(tetrahydro-furan-2-yl)-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143437 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 4470 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054593&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54125261 103951178 CHEMBL143437 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778480 Clc1ccc(Oc2ccc(NC(=O)C(C#N)C(=O)C3CC3)cc2)cc1 InChI=1S/C19H15ClN2O3/c20-13-3-7-15(8-4-13)25-16-9-5-14(6-10-16)22-19(24)17(11-21)18(23)12-1-2-12/h3-10,12,17H,1-2H2,(H,22,24) ZECMMNOVVURPKS-UHFFFAOYSA-N 50054561 (Z)-N-[4-(4-Chloro-phenoxy)-phenyl]-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL141237 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 832 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054561 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054561&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54542338 103951146 CHEMBL141237 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778481 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1SC(F)(F)F InChI=1S/C15H13F3N2O2S/c1-8-6-10(4-5-12(8)23-15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,20,22) VFCOPEZQGPYPNI-UHFFFAOYSA-N 50054590 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-trifluoromethylsulfanyl-phenyl)-acrylamide::CHEMBL343081 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 178 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054590&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929468 103951175 CHEMBL343081 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778482 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C#C)cc1 InChI=1S/C13H7F3N2O2/c1-2-11(19)10(7-17)12(20)18-9-5-3-8(4-6-9)13(14,15)16/h1,3-6,10H,(H,18,20) QTUUBMGLEZJDAH-UHFFFAOYSA-N 50054596 (Z)-2-Cyano-3-hydroxy-pent-2-en-4-ynoic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL344996 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 2090 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054596&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54246774 103951181 CHEMBL344996 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778483 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)nc1 InChI=1S/C13H10F3N3O2/c14-13(15,16)8-3-4-10(18-6-8)19-12(21)9(5-17)11(20)7-1-2-7/h3-4,6-7,9H,1-2H2,(H,18,19,21) TUGYWXLKAAQFFM-UHFFFAOYSA-N 50054597 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(5-trifluoromethyl-pyridin-2-yl)-acrylamide::CHEMBL140558 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 17 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054597&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54334165 103951182 CHEMBL140558 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778484 CN(C(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1)c1ccc(Cl)cc1 InChI=1S/C21H18ClN3O3/c1-25(17-10-6-15(22)7-11-17)21(28)14-4-8-16(9-5-14)24-20(27)18(12-23)19(26)13-2-3-13/h4-11,13,18H,2-3H2,1H3,(H,24,27) HOGHBEHZKOTCLX-UHFFFAOYSA-N 50054598 N-(4-Chloro-phenyl)-4-((Z)-2-cyano-3-cyclopropyl-3-hydroxy-acryloylamino)-N-methyl-benzamide::CHEMBL341721 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 19100 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054598&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53887615 103951183 CHEMBL341721 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778485 O=C(Nc1ccncc1)C(C#N)C(=O)C1CC1 InChI=1S/C12H11N3O2/c13-7-10(11(16)8-1-2-8)12(17)15-9-3-5-14-6-4-9/h3-6,8,10H,1-2H2,(H,14,15,17) NDRKRVMCYBMMIG-UHFFFAOYSA-N 50054575 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-pyridin-4-yl-acrylamide::CHEMBL342581 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 11700 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054575&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54105817 103951160 CHEMBL342581 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778486 Clc1cccc(NC(=O)C(C#N)C(=O)C2CC2)c1 InChI=1S/C13H11ClN2O2/c14-9-2-1-3-10(6-9)16-13(18)11(7-15)12(17)8-4-5-8/h1-3,6,8,11H,4-5H2,(H,16,18) JYRIARPHFUETPV-UHFFFAOYSA-N 50054558 (Z)-N-(3-Chloro-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL141015 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 3000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054558&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411781 103951143 CHEMBL141015 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778487 O=C(Nc1ccc(CCc2ccccc2)cc1)C(C#N)C(=O)C1CC1 InChI=1S/C21H20N2O2/c22-14-19(20(24)17-10-11-17)21(25)23-18-12-8-16(9-13-18)7-6-15-4-2-1-3-5-15/h1-5,8-9,12-13,17,19H,6-7,10-11H2,(H,23,25) BCOCOCYSHNXUEM-UHFFFAOYSA-N 50054589 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-phenethyl-phenyl)-acrylamide::CHEMBL139647 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 630 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054589&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53675019 103951174 CHEMBL139647 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778488 FC(F)(F)c1cccc(NC(=O)C(C#N)C(=O)C2CC2)c1 InChI=1S/C14H11F3N2O2/c15-14(16,17)9-2-1-3-10(6-9)19-13(21)11(7-18)12(20)8-4-5-8/h1-3,6,8,11H,4-5H2,(H,19,21) MROSLRWWFIDOCX-UHFFFAOYSA-N 50054599 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-trifluoromethyl-phenyl)-acrylamide::CHEMBL140115 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 479 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054599&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54087611 103951184 CHEMBL140115 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778489 Clc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C13H11ClN2O2/c14-9-3-5-10(6-4-9)16-13(18)11(7-15)12(17)8-1-2-8/h3-6,8,11H,1-2H2,(H,16,18) GWQBPNMINIQDPJ-UHFFFAOYSA-N 50054584 (Z)-N-(4-Chloro-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143518 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 36 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054584&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53861275 103951169 CHEMBL143518 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778490 CC(=C)C(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C14H11F3N2O2/c1-8(2)12(20)11(7-18)13(21)19-10-5-3-9(4-6-10)14(15,16)17/h3-6,11H,1H2,2H3,(H,19,21) UFJNSGIBUJADFQ-UHFFFAOYSA-N 50054543 2-cyano-3-hydroxy-4-methyl-N-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide::(Z)-2-Cyano-3-hydroxy-4-methyl-penta-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL141086 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 195 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054543 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054543&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54350498 103951128 CHEMBL141086 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778491 FC(F)(F)Sc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O2S/c15-14(16,17)22-10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) NYPCOHOWTLQKKY-UHFFFAOYSA-N 50054573 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethylsulfanyl-phenyl)-acrylamide::CHEMBL141248 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 100 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054573&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54137250 103951158 CHEMBL141248 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778492 Clc1ccc(\C=C\c2ccc(NC(=O)C(C#N)C(=O)C3CC3)cc2)cc1 InChI=1S/C21H17ClN2O2/c22-17-9-3-14(4-10-17)1-2-15-5-11-18(12-6-15)24-21(26)19(13-23)20(25)16-7-8-16/h1-6,9-12,16,19H,7-8H2,(H,24,26) JRIYWFQBQWRXJN-UHFFFAOYSA-N 50054576 (Z)-N-{4-[(E)-2-(4-Chloro-phenyl)-vinyl]-phenyl}-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL538406 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 11700 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054576&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929467 103951161 CHEMBL538406 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778493 CCc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1C(F)(F)F InChI=1S/C16H15F3N2O2/c1-2-9-7-11(5-6-13(9)16(17,18)19)21-15(23)12(8-20)14(22)10-3-4-10/h5-7,10,12H,2-4H2,1H3,(H,21,23) XGLWOJFNZFWUOW-UHFFFAOYSA-N 50054564 (Z)-2-Cyano-3-cyclopropyl-N-(3-ethyl-4-trifluoromethyl-phenyl)-3-hydroxy-acrylamide::CHEMBL357459 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 40 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054564 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054564&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54468235 103951149 CHEMBL357459 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778494 FC(F)(F)S(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O3S/c15-14(16,17)23(22)10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) HWZMCOGRZDFBES-UHFFFAOYSA-N 50054581 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethanesulfinyl-phenyl)-acrylamide::CHEMBL358621 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 16 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054581&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53900833 103951166 CHEMBL358621 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778495 FC(F)(F)c1csc(n1)-c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C17H12F3N3O2S/c18-17(19,20)13-8-26-16(23-13)10-3-5-11(6-4-10)22-15(25)12(7-21)14(24)9-1-2-9/h3-6,8-9,12H,1-2H2,(H,22,25) VUMSACFELULPDY-UHFFFAOYSA-N 50054546 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-[4-(4-trifluoromethyl-thiazol-2-yl)-phenyl]-acrylamide::CHEMBL143458 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 3000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054546 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054546&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54411558 103951131 CHEMBL143458 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778496 FC(F)(F)Oc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H11F3N2O3/c15-14(16,17)22-10-5-3-9(4-6-10)19-13(21)11(7-18)12(20)8-1-2-8/h3-6,8,11H,1-2H2,(H,19,21) ICIPZHFRARCJFV-UHFFFAOYSA-N 50054556 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-trifluoromethoxy-phenyl)-acrylamide::CHEMBL344913 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 173 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054556 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054556&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411785 103951141 CHEMBL344913 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778497 O=C(Nc1ccc(cc1)-c1ncco1)C(C#N)C(=O)C1CC1 InChI=1S/C16H13N3O3/c17-9-13(14(20)10-1-2-10)15(21)19-12-5-3-11(4-6-12)16-18-7-8-22-16/h3-8,10,13H,1-2H2,(H,19,21) DEYMKOPHPRXMET-UHFFFAOYSA-N 50054567 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-oxazol-2-yl-phenyl)-acrylamide::CHEMBL342124 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 20000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054567 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054567&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53756670 103951152 CHEMBL342124 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778498 Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) VHOGYURTWQBHIL-UHFFFAOYSA-N 50054601 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide::5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide::5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide::Arava (TN)::CHEMBL960::alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide::LEFLUNOMIDE Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 9 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054601 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054601&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 3899 103951186 CHEMBL960 DB01097 C07905 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778499 Cc1cc(Cl)ccc1NC(=O)C(C#N)C(=O)C1CC1 InChI=1S/C14H13ClN2O2/c1-8-6-10(15)4-5-12(8)17-14(19)11(7-16)13(18)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,17,19) VRFWIGXULWTUGF-UHFFFAOYSA-N 50054602 (Z)-N-(4-Chloro-2-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL139818 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 1250 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054602&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54406750 103951187 CHEMBL139818 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778500 O=C(Nc1ccc(cc1)C#N)C(C#N)C(=O)C1CC1 InChI=1S/C14H11N3O2/c15-7-9-1-5-11(6-2-9)17-14(19)12(8-16)13(18)10-3-4-10/h1-2,5-6,10,12H,3-4H2,(H,17,19) GSSLQBZZKKOMAF-UHFFFAOYSA-N 50054587 Alpha-cyano-beta-hydroxy enamide, 6::CHEMBL141195::(Z)-2-Cyano-N-(4-cyano-phenyl)-3-cyclopropyl-3-hydroxy-acrylamide Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 42 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054587&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 10198927 103951172 CHEMBL141195 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778501 FC(F)(F)c1ccc(Oc2ccc(NC(=O)C(C#N)C(=O)C3CC3)cc2)cc1 InChI=1S/C20H15F3N2O3/c21-20(22,23)13-3-7-15(8-4-13)28-16-9-5-14(6-10-16)25-19(27)17(11-24)18(26)12-1-2-12/h3-10,12,17H,1-2H2,(H,25,27) LSATVMSOUHYMMD-UHFFFAOYSA-N 50054603 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-[4-(4-trifluoromethyl-phenoxy)-phenyl]-acrylamide::CHEMBL341877 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 3550 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054603&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54049730 103951188 CHEMBL341877 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778502 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C=C)cc1 InChI=1S/C13H9F3N2O2/c1-2-11(19)10(7-17)12(20)18-9-5-3-8(4-6-9)13(14,15)16/h2-6,10H,1H2,(H,18,20) QPHLDGYCSPSWEZ-UHFFFAOYSA-N 50054600 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide::(Z)-2-Cyano-3-hydroxy-penta-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL141047 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 178 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054600&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54239937 103951185 CHEMBL141047 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778503 O=C(Nc1ccc(cc1)-c1cccs1)C(C#N)C(=O)C1CC1 InChI=1S/C17H14N2O2S/c18-10-14(16(20)12-3-4-12)17(21)19-13-7-5-11(6-8-13)15-2-1-9-22-15/h1-2,5-9,12,14H,3-4H2,(H,19,21) BDFZJEFBLPMTRT-UHFFFAOYSA-N 50054605 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-thiophen-2-yl-phenyl)-acrylamide::CHEMBL141074 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 2510 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054605&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53676064 103951190 CHEMBL141074 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778504 O=C(Nc1ccc(CC#N)cc1)C(C#N)C(=O)C1CC1 InChI=1S/C15H13N3O2/c16-8-7-10-1-5-12(6-2-10)18-15(20)13(9-17)14(19)11-3-4-11/h1-2,5-6,11,13H,3-4,7H2,(H,18,20) CNIGWACYSJNCRP-UHFFFAOYSA-N 50054595 (Z)-2-Cyano-N-(4-cyanomethyl-phenyl)-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL140210 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 37200 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054595&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929469 103951180 CHEMBL140210 C04116 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778505 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C#C)cc1 InChI=1S/C13H7F3N2O2/c1-2-11(19)10(7-17)12(20)18-9-5-3-8(4-6-9)13(14,15)16/h1,3-6,10H,(H,18,20) QTUUBMGLEZJDAH-UHFFFAOYSA-N 50054596 (Z)-2-Cyano-3-hydroxy-pent-2-en-4-ynoic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL344996 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 500 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054596&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54246774 103951181 CHEMBL344996 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778506 NC(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H13N3O3/c15-7-11(12(18)8-1-2-8)14(20)17-10-5-3-9(4-6-10)13(16)19/h3-6,8,11H,1-2H2,(H2,16,19)(H,17,20) NSZIEVSRHNRGRB-UHFFFAOYSA-N 50054604 4-((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-acryloylamino)-benzamide::CHEMBL342525 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 14100 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054604&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54128992 103951189 CHEMBL342525 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778507 CN1CCCC1C(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C16H16F3N3O2/c1-22-8-2-3-13(22)14(23)12(9-20)15(24)21-11-6-4-10(5-7-11)16(17,18)19/h4-7,12-13H,2-3,8H2,1H3,(H,21,24) USCQNAKKBRTMAX-UHFFFAOYSA-N 50054566 (Z)-2-Cyano-3-hydroxy-3-(1-methyl-pyrrolidin-2-yl)-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143756 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054566&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54369451 103951151 CHEMBL143756 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778508 FC(F)(F)c1ccc(Oc2ccc(NC(=O)C(C#N)C(=O)C3CC3)cc2)cc1 InChI=1S/C20H15F3N2O3/c21-20(22,23)13-3-7-15(8-4-13)28-16-9-5-14(6-10-16)25-19(27)17(11-24)18(26)12-1-2-12/h3-10,12,17H,1-2H2,(H,25,27) LSATVMSOUHYMMD-UHFFFAOYSA-N 50054603 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-[4-(4-trifluoromethyl-phenoxy)-phenyl]-acrylamide::CHEMBL341877 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 1510 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054603&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54049730 103951188 CHEMBL341877 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778509 Nc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C13H13N3O2/c14-7-11(12(17)8-1-2-8)13(18)16-10-5-3-9(15)4-6-10/h3-6,8,11H,1-2,15H2,(H,16,18) NODUWQXSBBXOBD-UHFFFAOYSA-N 50054592 (Z)-N-(4-Amino-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide; hydrochloride::CHEMBL543919 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 21900 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054592&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 89167333 103951177 CHEMBL543919 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778510 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CCCC2)cc1 InChI=1S/C16H15F3N2O2/c17-16(18,19)11-5-7-12(8-6-11)21-15(23)13(9-20)14(22)10-3-1-2-4-10/h5-8,10,13H,1-4H2,(H,21,23) QGLCNGHFYRTBAV-UHFFFAOYSA-N 50054580 2-cyano-3-cyclopentyl-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide::(Z)-2-Cyano-3-cyclopentyl-3-hydroxy-N-(4-trifluoromethyl-phenyl)-acrylamide::CHEMBL143438 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 28200 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054580&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 15411783 103951165 CHEMBL143438 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778511 CC=CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F |w:1.0| InChI=1S/C14H11F3N2O2/c1-2-3-12(20)11(8-18)13(21)19-10-6-4-9(5-7-10)14(15,16)17/h2-7,11H,1H3,(H,19,21) YWNKCKQRBLHMNC-UHFFFAOYSA-N 50054565 CHEMBL141472::CHEMBL344613::(2Z,4E)-2-Cyano-3-hydroxy-hexa-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 1410 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054565&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929465 103951150 CHEMBL344613CHEMBL141472 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778512 CC(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C15H14N2O3/c1-9(18)10-4-6-12(7-5-10)17-15(20)13(8-16)14(19)11-2-3-11/h4-7,11,13H,2-3H2,1H3,(H,17,20) ICGVAJSZFZOTQP-UHFFFAOYSA-N 50054606 (Z)-N-(4-Acetyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143319 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 3800 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054606&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53908769 103951191 CHEMBL143319 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778513 Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1Cl InChI=1S/C14H13ClN2O2/c1-8-2-5-10(6-12(8)15)17-14(19)11(7-16)13(18)9-3-4-9/h2,5-6,9,11H,3-4H2,1H3,(H,17,19) MBVWUNQMPJDNBR-UHFFFAOYSA-N 50054591 (Z)-N-(3-Chloro-4-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL141104 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 282 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054591&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54064273 103951176 CHEMBL141104 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778514 [O-][N+](=O)c1ccc(NC(=O)C(=C=[N-])C(=[OH+])C2CC2)cc1 InChI=1S/C13H10N3O4/c14-7-11(12(17)8-1-2-8)13(18)15-9-3-5-10(6-4-9)16(19)20/h3-6,8H,1-2H2,(H,15,18)/q-1/p+1 QHPPLTUFMYEUSN-UHFFFAOYSA-O 50054557 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-nitro-phenyl)-acrylamide::CHEMBL344556 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 21 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054557 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054557&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54680416 103951142 CHEMBL344556 C02125 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778515 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C=C)cc1 InChI=1S/C13H9F3N2O2/c1-2-11(19)10(7-17)12(20)18-9-5-3-8(4-6-9)13(14,15)16/h2-6,10H,1H2,(H,18,20) QPHLDGYCSPSWEZ-UHFFFAOYSA-N 50054600 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide::(Z)-2-Cyano-3-hydroxy-penta-2,4-dienoic acid (4-trifluoromethyl-phenyl)-amide::CHEMBL141047 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 23 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054600&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54239937 103951185 CHEMBL141047 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778516 Clc1ccc(cc1)C#Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C21H15ClN2O2/c22-17-9-3-14(4-10-17)1-2-15-5-11-18(12-6-15)24-21(26)19(13-23)20(25)16-7-8-16/h3-6,9-12,16,19H,7-8H2,(H,24,26) LKRKCGWQWTYKLX-UHFFFAOYSA-N 50054571 (Z)-N-[4-(4-Chloro-phenylethynyl)-phenyl]-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL139699 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 17800 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054571&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54038524 103951156 CHEMBL139699 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778517 CS(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O3S/c1-20(19)11-6-4-10(5-7-11)16-14(18)12(8-15)13(17)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,16,18) HODJUNLDOQWOKF-UHFFFAOYSA-N 50054588 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methanesulfinyl-phenyl)-acrylamide::CHEMBL357498 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 832 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054588&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53887442 103951173 CHEMBL357498 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778518 O=C(Nc1ccc(cc1)-c1cccs1)C(C#N)C(=O)C1CC1 InChI=1S/C17H14N2O2S/c18-10-14(16(20)12-3-4-12)17(21)19-13-7-5-11(6-8-13)15-2-1-9-22-15/h1-2,5-9,12,14H,3-4H2,(H,19,21) BDFZJEFBLPMTRT-UHFFFAOYSA-N 50054605 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-thiophen-2-yl-phenyl)-acrylamide::CHEMBL141074 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 631 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054605&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53676064 103951190 CHEMBL141074 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778519 NC(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H13N3O3/c15-7-11(12(18)8-1-2-8)14(20)17-10-5-3-9(4-6-10)13(16)19/h3-6,8,11H,1-2H2,(H2,16,19)(H,17,20) NSZIEVSRHNRGRB-UHFFFAOYSA-N 50054604 4-((Z)-2-Cyano-3-cyclopropyl-3-hydroxy-acryloylamino)-benzamide::CHEMBL342525 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054604&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54128992 103951189 CHEMBL342525 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778520 CSc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O2S/c1-19-11-6-4-10(5-7-11)16-14(18)12(8-15)13(17)9-2-3-9/h4-7,9,12H,2-3H2,1H3,(H,16,18) MOXHJPCGLKALOZ-UHFFFAOYSA-N 50054552 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-methylsulfanyl-phenyl)-acrylamide::CHEMBL143816 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 13 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054552 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054552&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54083688 103951137 CHEMBL143816 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778521 Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18) VHOGYURTWQBHIL-UHFFFAOYSA-N 50054601 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide::5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide::5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide::Arava (TN)::CHEMBL960::alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide::LEFLUNOMIDE Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 30 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054601 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054601&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 3899 103951186 CHEMBL960 DB01097 C07905 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778522 Cc1cc(NC(=O)C(C#N)C(=O)C2CC2)ccc1OC(F)(F)F InChI=1S/C15H13F3N2O3/c1-8-6-10(4-5-12(8)23-15(16,17)18)20-14(22)11(7-19)13(21)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,20,22) WPNXQQAFDXHIMB-UHFFFAOYSA-N 50054574 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-methyl-4-trifluoromethoxy-phenyl)-acrylamide::CHEMBL141774 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 178 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054574&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91929466 103951159 CHEMBL141774 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778524 FC(F)(F)c1ccccc1NC(=O)C(C#N)C(=O)C1CC1 InChI=1S/C14H11F3N2O2/c15-14(16,17)10-3-1-2-4-11(10)19-13(21)9(7-18)12(20)8-5-6-8/h1-4,8-9H,5-6H2,(H,19,21) INRRYKXWZBFZOV-UHFFFAOYSA-N 50054577 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(2-trifluoromethyl-phenyl)-acrylamide::CHEMBL141144 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus >100000 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054577&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53925793 103951162 CHEMBL141144 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778525 CC(=O)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C15H14N2O3/c1-9(18)10-4-6-12(7-5-10)17-15(20)13(8-16)14(19)11-2-3-11/h4-7,11,13H,2-3H2,1H3,(H,17,20) ICGVAJSZFZOTQP-UHFFFAOYSA-N 50054606 (Z)-N-(4-Acetyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL143319 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 68 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054606&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53908769 103951191 CHEMBL143319 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778526 Cc1cc(Cl)ccc1NC(=O)C(C#N)C(=O)C1CC1 InChI=1S/C14H13ClN2O2/c1-8-6-10(15)4-5-12(8)17-14(19)11(7-16)13(18)9-2-3-9/h4-6,9,11H,2-3H2,1H3,(H,17,19) VRFWIGXULWTUGF-UHFFFAOYSA-N 50054602 (Z)-N-(4-Chloro-2-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL139818 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 3720 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054602&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54406750 103951187 CHEMBL139818 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778527 Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C14H14N2O2/c1-9-2-6-11(7-3-9)16-14(18)12(8-15)13(17)10-4-5-10/h2-3,6-7,10,12H,4-5H2,1H3,(H,16,18) YFDCKORXPDAUIO-UHFFFAOYSA-N 50054547 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-p-tolyl-acrylamide::CHEMBL141040 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 288 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054547&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 47275544 103951132 CHEMBL141040 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778528 Brc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1 InChI=1S/C13H11BrN2O2/c14-9-3-5-10(6-4-9)16-13(18)11(7-15)12(17)8-1-2-8/h3-6,8,11H,1-2H2,(H,16,18) WVQOCQNOMMJAIS-UHFFFAOYSA-N 50054548 (Z)-N-(4-Bromo-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL142214 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 36 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054548&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54452109 103951133 CHEMBL142214 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778529 FC(F)(F)c1cccc(NC(=O)C(C#N)C(=O)C2CC2)c1 InChI=1S/C14H11F3N2O2/c15-14(16,17)9-2-1-3-10(6-9)19-13(21)11(7-18)12(20)8-4-5-8/h1-3,6,8,11H,4-5H2,(H,19,21) MROSLRWWFIDOCX-UHFFFAOYSA-N 50054599 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(3-trifluoromethyl-phenyl)-acrylamide::CHEMBL140115 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 525 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054599&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54087611 103951184 CHEMBL140115 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778530 FC(F)(F)c1ccc(NC(=O)C(C#N)C(=O)C2CC2)nc1 InChI=1S/C13H10F3N3O2/c14-13(15,16)8-3-4-10(18-6-8)19-12(21)9(5-17)11(20)7-1-2-7/h3-4,6-7,9H,1-2H2,(H,18,19,21) TUGYWXLKAAQFFM-UHFFFAOYSA-N 50054597 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-(5-trifluoromethyl-pyridin-2-yl)-acrylamide::CHEMBL140558 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 158 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054597&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54334165 103951182 CHEMBL140558 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778531 O=C(Nc1ccccc1)C(C#N)C(=O)C1CC1 InChI=1S/C13H12N2O2/c14-8-11(12(16)9-6-7-9)13(17)15-10-4-2-1-3-5-10/h1-5,9,11H,6-7H2,(H,15,17) UNRSQHSAEAPJRT-UHFFFAOYSA-N 50054569 (Z)-2-Cyano-3-cyclopropyl-3-hydroxy-N-phenyl-acrylamide::CHEMBL141041 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 1580 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054569&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 47275637 103951154 CHEMBL141041 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 50778532 O=C(Nc1ccc(cc1)-c1ccco1)C(C#N)C(=O)C1CC1 InChI=1S/C17H14N2O3/c18-10-14(16(20)12-3-4-12)17(21)19-13-7-5-11(6-8-13)15-2-1-9-22-15/h1-2,5-9,12,14H,3-4H2,(H,19,21) MDFZKERGJWPYSZ-UHFFFAOYSA-N 50054568 (Z)-2-Cyano-3-cyclopropyl-N-(4-furan-2-yl-phenyl)-3-hydroxy-acrylamide::CHEMBL139611 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 1780 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50054568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50054568&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 54066321 103951153 CHEMBL139611 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50778533 O=C(Nc1ccc(cc1)-c1ccccc1)C(C#N)C(=O)C1CC1 InChI=1S/C19H16N2O2/c20-12-17(18(22)15-6-7-15)19(23)21-16-10-8-14(9-11-16)13-4-2-1-3-5-13/h1-5,8-11,15,17H,6-7H2,(H,21,23) DIIHYLMEQKHUBY-UHFFFAOYSA-N 29026 CHEMBL142996::cyanocyclopropylpropenamide, 11 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 1480 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=29026 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=29026&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 53761678 81054455 CHEMBL142996 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50994453 Clc1ccc(\C=C/c2ccc(NC(=O)C(C#N)C(=O)C3CC3)cc2)cc1 InChI=1S/C21H17ClN2O2/c22-17-9-3-14(4-10-17)1-2-15-5-11-18(12-6-15)24-21(26)19(13-23)20(25)16-7-8-16/h1-6,9-12,16,19H,7-8H2,(H,24,26) JRIYWFQBQWRXJN-UHFFFAOYSA-N 50407985 CHEMBL2111978 Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 40 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50407985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50407985&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91900639 163357009 CHEMBL2111978 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707 50994454 Clc1ccc(\C=C/c2ccc(NC(=O)C(C#N)C(=O)C3CC3)cc2)cc1 InChI=1S/C21H17ClN2O2/c22-17-9-3-14(4-10-17)1-2-15-5-11-18(12-6-15)24-21(26)19(13-23)20(25)16-7-8-16/h1-6,9-12,16,19H,7-8H2,(H,24,26) JRIYWFQBQWRXJN-UHFFFAOYSA-N 50407985 CHEMBL2111978 Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 22 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50407985 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50407985&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 91900639 163357009 CHEMBL2111978 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 51032177 CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,10H,1H3,(H,17,19) NABQBYDEMLGCEO-UHFFFAOYSA-N 14712 A77 1726::CHEMBL973::(2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide::CHEMBL999::TERIFLUNOMIDE Dihydroorotate dehydrogenase (quinone), mitochondrial Mus musculus 69 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50001588&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14712&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 23500906 46515042 CHEMBL999CHEMBL973 1 MAWRQLRKRALDAAIILGGGGLLFTSYLTATGDDHFYAEYLMPALQRLLDPESAHRLAVRVISLGLLPRATFQDSNMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSAVEHRLRARQQKQTQLTTDGLPLGINLGKNKTSVDAAADYVEGVRILGPLADYLVVNVSSPNTAGLRSLQGKTELRRLLSKVLQERDALKGPQKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIITNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGTIPIIGVGGVSSGQDALEKIQAGASLVQLYTALTFLGPPVVARVKRELEALLKERGFNTVTDAIGVDHRR 6OC1,6OC0,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8K4F,8DHH,8DHG,8DHF,7K2U,9EG9,9CZE,9CCC,5K9D,5K9C,2B0M,9BKO,9BKN,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,1D3H,1D3G,9S1I,9EZ9,8RAK,7Z6C,6QU7,6M2B,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,2FQI,2FPY,2FPV,2FPT Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_MOUSE O35435 51032178 CC(=O)C(C#N)C(=O)Nc1ccc(cc1)C(F)(F)F InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,10H,1H3,(H,17,19) NABQBYDEMLGCEO-UHFFFAOYSA-N 14712 A77 1726::CHEMBL973::(2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide::CHEMBL999::TERIFLUNOMIDE Dihydroorotate dehydrogenase (quinone), mitochondrial Rattus norvegicus 13 ChEMBL 10.1021/jm9604437 10.7270/Q20G3KSX 8917650 Kuo, EA; Hambleton, PT; Kay, DP; Evans, PL; Matharu, SS; Little, E; McDowall, N; Jones, CB; Hedgecock, CJ; Yea, CM; Chan, AW; Hairsine, PW; Ager, IR; Tully, WR; Williamson, RA; Westwood, R 12/26/1996 11/2/2012 Hoechst Marion Roussel http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=14712 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1713&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=14712&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search 23500906 46515042 CHEMBL999CHEMBL973 1 MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR 1UUO,1UUM,4ORI,5MVD Dihydroorotate dehydrogenase (quinone), mitochondrial PYRD_RAT Q63707