BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 50012333 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccccc3)c(Cl)cc2[nH]c1=O InChI=1S/C31H33ClN4O3/c1-19-14-20(2)16-21(15-19)28-29(39-13-11-22-8-6-7-12-33-22)24-17-27(25(32)18-26(24)35-30(28)37)36-31(38)34-23-9-4-3-5-10-23/h3-5,9-10,14-18,22,33H,6-8,11-13H2,1-2H3,(H,35,37)(H2,34,36,38) DLJDKEONMYMAPN-UHFFFAOYSA-N 50090561 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-phenyl-urea::CHEMBL297238 Gonadotropin-releasing hormone receptor Rattus norvegicus 10 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090561 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090561&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292974 103989033 CHEMBL297238 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012334 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(CC(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C30H32ClN5O3/c1-18-11-19(2)13-21(12-18)28-29(39-10-7-22-5-3-4-8-33-22)23-14-20(24(31)16-25(23)35-30(28)38)15-27(37)36-26-6-9-32-17-34-26/h6,9,11-14,16-17,22,33H,3-5,7-8,10,15H2,1-2H3,(H,35,38)(H,32,34,36,37) YNQVAUVRVQAGPS-UHFFFAOYSA-N 50090547 2-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-N-pyrimidin-4-yl-acetamide::CHEMBL45501 Gonadotropin-releasing hormone receptor Rattus norvegicus 2500 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090547&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293223 103989019 CHEMBL45501 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012335 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3cccnc3)c(Cl)cc2[nH]c1=O InChI=1S/C30H32ClN5O3/c1-18-12-19(2)14-20(13-18)27-28(39-11-8-21-6-3-4-10-33-21)23-15-26(24(31)16-25(23)35-29(27)37)36-30(38)34-22-7-5-9-32-17-22/h5,7,9,12-17,21,33H,3-4,6,8,10-11H2,1-2H3,(H,35,37)(H2,34,36,38) JTXQMDDPDFIHBE-UHFFFAOYSA-N 50090539 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyridin-3-yl-urea::CHEMBL48592 Gonadotropin-releasing hormone receptor Rattus norvegicus 1300 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090539 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090539&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293195 103989011 CHEMBL48592 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012336 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3cccnc3)c(Cl)cc2[nH]c1=O InChI=1S/C30H32ClN5O3/c1-18-12-19(2)14-20(13-18)27-28(39-11-8-21-6-3-4-10-33-21)23-15-26(24(31)16-25(23)35-29(27)37)36-30(38)34-22-7-5-9-32-17-22/h5,7,9,12-17,21,33H,3-4,6,8,10-11H2,1-2H3,(H,35,37)(H2,34,36,38) JTXQMDDPDFIHBE-UHFFFAOYSA-N 50090539 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyridin-3-yl-urea::CHEMBL48592 Gonadotropin-releasing hormone receptor Rattus norvegicus 20 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090539 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090539&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293195 103989011 CHEMBL48592 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012337 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O InChI=1S/C28H33ClN4O3/c1-16-11-17(2)13-18(12-16)25-26(36-10-8-19-5-3-4-9-30-19)21-14-24(33-28(35)31-20-6-7-20)22(29)15-23(21)32-27(25)34/h11-15,19-20,30H,3-10H2,1-2H3,(H,32,34)(H2,31,33,35) GTZRWABUMPGTQA-UHFFFAOYSA-N 50090538 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL296321 Gonadotropin-releasing hormone receptor Rattus norvegicus 1.1 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090538 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090538&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 22129998 103989010 CHEMBL296321 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012338 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-11-18(2)13-19(12-17)26-27(39-10-7-20-5-3-4-8-32-20)21-14-24(22(30)15-23(21)34-28(26)37)35-29(38)36-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H2,31,33,35,36,38) IDBKGTFOVFGQBA-UHFFFAOYSA-N 50090555 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrimidin-4-yl-urea::CHEMBL50433 Gonadotropin-releasing hormone receptor Rattus norvegicus 0.400000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090555&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293163 103989027 CHEMBL50433 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012339 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(CC(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C30H32ClN5O3/c1-18-11-19(2)13-21(12-18)28-29(39-10-7-22-5-3-4-8-33-22)23-14-20(24(31)16-25(23)35-30(28)38)15-27(37)36-26-6-9-32-17-34-26/h6,9,11-14,16-17,22,33H,3-5,7-8,10,15H2,1-2H3,(H,35,38)(H,32,34,36,37) YNQVAUVRVQAGPS-UHFFFAOYSA-N 50090547 2-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-N-pyrimidin-4-yl-acetamide::CHEMBL45501 Gonadotropin-releasing hormone receptor Rattus norvegicus 7.9 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090547&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293223 103989019 CHEMBL45501 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012340 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccccn3)c(Cl)cc2[nH]c1=O InChI=1S/C30H32ClN5O3/c1-18-13-19(2)15-20(14-18)27-28(39-12-9-21-7-3-5-10-32-21)22-16-25(23(31)17-24(22)34-29(27)37)35-30(38)36-26-8-4-6-11-33-26/h4,6,8,11,13-17,21,32H,3,5,7,9-10,12H2,1-2H3,(H,34,37)(H2,33,35,36,38) SMWNCXKOTUSXIC-UHFFFAOYSA-N 50090570 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyridin-2-yl-urea::CHEMBL295791 Gonadotropin-releasing hormone receptor Rattus norvegicus 463 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090570&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 10209293 103989042 CHEMBL295791 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012341 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-11-18(2)13-19(12-17)26-27(39-10-6-20-5-3-4-7-32-20)21-14-24(22(30)15-23(21)34-28(26)37)35-29(38)36-25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H2,33,35,36,38) ADRCRSPDCZNNQH-UHFFFAOYSA-N 50090552 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrazin-2-yl-urea::CHEMBL50283 Gonadotropin-releasing hormone receptor Rattus norvegicus 0.300000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090552 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090552&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293301 103989024 CHEMBL50283 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50012342 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)c3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)21-14-24(22(30)15-23(21)34-29(26)37)35-28(36)25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,35,36) YHIBXEIBSOLHKK-UHFFFAOYSA-N 50090558 Pyrazine-2-carboxylic acid [7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-amide::CHEMBL295917 Gonadotropin-releasing hormone receptor Rattus norvegicus 1920 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090558&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293111 103989030 CHEMBL295917 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161676 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccc(c(Cl)c3)-c3ccccc3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C28H25Cl2N3O4/c29-22-14-18(9-10-20(22)17-6-2-1-3-7-17)26-27(37-13-11-19-8-4-5-12-31-19)21-15-25(33(35)36)23(30)16-24(21)32-28(26)34/h1-3,6-7,9-10,14-16,19,31H,4-5,8,11-13H2,(H,32,34) VDQDGNRGFYPXKV-UHFFFAOYSA-N 50090537 7-Chloro-3-(2-chloro-biphenyl-4-yl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL49028 Gonadotropin-releasing hormone receptor Rattus norvegicus 900 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090537 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090537&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292683 103989009 CHEMBL49028 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161677 Cc1cc(cc(C)c1C)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C30H32ClN5O3/c1-17-12-20(13-18(2)19(17)3)27-28(39-11-8-21-6-4-5-9-33-21)23-14-22(24(31)15-25(23)35-30(27)38)29(37)36-26-7-10-32-16-34-26/h7,10,12-16,21,33H,4-6,8-9,11H2,1-3H3,(H,35,38)(H,32,34,36,37) LQGVIIDLWCIUBJ-UHFFFAOYSA-N 50090540 7-Chloro-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide::7-Chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-3-((S)-3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide::CHEMBL48192 Gonadotropin-releasing hormone receptor Homo sapiens 0.300000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090540 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090540&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 10053165 103989012 CHEMBL48192 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161678 Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O InChI=1S/C28H33ClN4O3/c1-16-11-17(2)13-18(12-16)25-26(36-10-8-19-5-3-4-9-30-19)21-14-24(33-28(35)31-20-6-7-20)22(29)15-23(21)32-27(25)34/h11-15,19-20,30H,3-10H2,1-2H3,(H,32,34)(H2,31,33,35) GTZRWABUMPGTQA-UHFFFAOYSA-N 50090541 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL297269 Gonadotropin-releasing hormone receptor Homo sapiens 2.3 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090541 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090541&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292939 103989013 CHEMBL297269 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161679 Cc1cc(CC#N)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C25H25ClN4O4/c1-15-10-16(5-7-27)12-17(11-15)23-24(34-9-6-18-4-2-3-8-28-18)19-13-22(30(32)33)20(26)14-21(19)29-25(23)31/h10-14,18,28H,2-6,8-9H2,1H3,(H,29,31) LCWYQPRMSFCGRL-UHFFFAOYSA-N 50090544 {3-[7-Chloro-6-nitro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-3-yl]-5-methyl-phenyl}-acetonitrile::CHEMBL298278 Gonadotropin-releasing hormone receptor Rattus norvegicus 18 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090544&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292833 103989016 CHEMBL298278 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161680 Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(NC(=O)Nc3cncnc3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-9-18(2)11-19(10-17)26-27(39-8-6-20-5-3-4-7-33-20)22-12-25(23(30)13-24(22)35-28(26)37)36-29(38)34-21-14-31-16-32-15-21/h9-16,20,33H,3-8H2,1-2H3,(H,35,37)(H2,34,36,38) GGUCKNMOSIHLKI-UHFFFAOYSA-N 50090545 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrimidin-5-yl-urea::CHEMBL417189 Gonadotropin-releasing hormone receptor Homo sapiens 57 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090545 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090545&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293285 103989017 CHEMBL417189 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161681 Cc1cccc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C23H24ClN3O4/c1-14-5-4-6-15(11-14)21-22(31-10-8-16-7-2-3-9-25-16)17-12-20(27(29)30)18(24)13-19(17)26-23(21)28/h4-6,11-13,16,25H,2-3,7-10H2,1H3,(H,26,28) BSNKXMNDTWQYRN-UHFFFAOYSA-N 50090546 7-Chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-3-m-tolyl-1H-quinolin-2-one::CHEMBL45661 Gonadotropin-releasing hormone receptor Rattus norvegicus 27 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090546 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090546&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292878 103989018 CHEMBL45661 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161683 Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(NC(=O)c3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)21-14-24(22(30)15-23(21)34-29(26)37)35-28(36)25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,35,36) YHIBXEIBSOLHKK-UHFFFAOYSA-N 50090548 Pyrazine-2-carboxylic acid [7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-amide::CHEMBL46312 Gonadotropin-releasing hormone receptor Homo sapiens 2 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090548&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292869 103989020 CHEMBL46312 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161684 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C24H26ClN3O4/c1-14-9-15(2)11-16(10-14)22-23(32-8-6-17-5-3-4-7-26-17)18-12-21(28(30)31)19(25)13-20(18)27-24(22)29/h9-13,17,26H,3-8H2,1-2H3,(H,27,29) IXZTVVBIBRTWRH-UHFFFAOYSA-N 50081148 CHEMBL294910::CHEMBL90725::7-Chloro-3-(3,5-dimethyl-phenyl)-6-nitro-4-((S)-2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one Gonadotropin-releasing hormone receptor Rattus norvegicus 10 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50081148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50081148&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 22124513 103981190 CHEMBL90725CHEMBL294910 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161685 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O InChI=1S/C28H33ClN4O3/c1-16-11-17(2)13-18(12-16)25-26(36-10-8-19-5-3-4-9-30-19)21-14-24(33-28(35)31-20-6-7-20)22(29)15-23(21)32-27(25)34/h11-15,19-20,30H,3-10H2,1-2H3,(H,32,34)(H2,31,33,35) GTZRWABUMPGTQA-UHFFFAOYSA-N 50090538 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL296321 Gonadotropin-releasing hormone receptor Rattus norvegicus 0.800000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090538 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090538&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 22129998 103989010 CHEMBL296321 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161686 Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(NC(=O)Nc3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-11-18(2)13-19(12-17)26-27(39-10-6-20-5-3-4-7-32-20)21-14-24(22(30)15-23(21)34-28(26)37)35-29(38)36-25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H2,33,35,36,38) ADRCRSPDCZNNQH-UHFFFAOYSA-N 50090549 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrazin-2-yl-urea::CHEMBL416651 Gonadotropin-releasing hormone receptor Homo sapiens 1.1 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090549 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090549&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292950 103989021 CHEMBL416651 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161687 Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(NC(=O)c3cncnc3)c(Cl)cc2[nH]c1=O InChI=1S/C29H30ClN5O3/c1-17-9-18(2)11-19(10-17)26-27(38-8-6-21-5-3-4-7-33-21)22-12-25(23(30)13-24(22)34-29(26)37)35-28(36)20-14-31-16-32-15-20/h9-16,21,33H,3-8H2,1-2H3,(H,34,37)(H,35,36) PSEYHHZOMVTYMJ-UHFFFAOYSA-N 50090550 Pyrimidine-5-carboxylic acid [7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-amide::CHEMBL49293 Gonadotropin-releasing hormone receptor Rattus norvegicus 25 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090550 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090550&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293112 103989022 CHEMBL49293 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161688 Clc1cc2[nH]c(=O)c(-c3ccc4ccccc4c3)c(OCCC3CCCCN3)c2cc1NC(=O)NC1CC1 InChI=1S/C30H31ClN4O3/c31-24-17-25-23(16-26(24)35-30(37)33-22-10-11-22)28(38-14-12-21-7-3-4-13-32-21)27(29(36)34-25)20-9-8-18-5-1-2-6-19(18)15-20/h1-2,5-6,8-9,15-17,21-22,32H,3-4,7,10-14H2,(H,34,36)(H2,33,35,37) HWQNINBYCILOFM-UHFFFAOYSA-N 50090551 1-[7-Chloro-3-naphthalen-2-yl-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL45675 Gonadotropin-releasing hormone receptor Rattus norvegicus 68 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090551 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090551&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293015 103989023 CHEMBL45675 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161689 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccccc3)c(Cl)cc2[nH]c1=O InChI=1S/C31H33ClN4O3/c1-19-14-20(2)16-21(15-19)28-29(39-13-11-22-8-6-7-12-33-22)24-17-27(25(32)18-26(24)35-30(28)37)36-31(38)34-23-9-4-3-5-10-23/h3-5,9-10,14-18,22,33H,6-8,11-13H2,1-2H3,(H,35,37)(H2,34,36,38) DLJDKEONMYMAPN-UHFFFAOYSA-N 50090561 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-phenyl-urea::CHEMBL297238 Gonadotropin-releasing hormone receptor Rattus norvegicus 3300 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090561 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090561&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292974 103989033 CHEMBL297238 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161690 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O InChI=1S/C28H33ClN4O3/c1-16-11-17(2)13-18(12-16)25-26(36-10-8-19-5-3-4-9-30-19)21-14-24(33-28(35)31-20-6-7-20)22(29)15-23(21)32-27(25)34/h11-15,19-20,30H,3-10H2,1-2H3,(H,32,34)(H2,31,33,35) GTZRWABUMPGTQA-UHFFFAOYSA-N 50090538 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL296321 Gonadotropin-releasing hormone receptor Rattus norvegicus 375 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090538 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090538&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 22129998 103989010 CHEMBL296321 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161691 Clc1cc(Cl)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C27H24Cl3N5O3/c28-16-9-15(10-17(29)11-16)24-25(38-8-5-18-3-1-2-6-32-18)20-12-19(21(30)13-22(20)34-27(24)37)26(36)35-23-4-7-31-14-33-23/h4,7,9-14,18,32H,1-3,5-6,8H2,(H,34,37)(H,31,33,35,36) YSUJBTKJKPWKBA-UHFFFAOYSA-N 50090553 7-Chloro-3-(3,5-dichloro-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide::CHEMBL46177 Gonadotropin-releasing hormone receptor Homo sapiens 1.1 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090553 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090553&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292868 103989025 CHEMBL46177 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161693 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O InChI=1S/C28H33ClN4O3/c1-16-11-17(2)13-18(12-16)25-26(36-10-8-19-5-3-4-9-30-19)21-14-24(33-28(35)31-20-6-7-20)22(29)15-23(21)32-27(25)34/h11-15,19-20,30H,3-10H2,1-2H3,(H,32,34)(H2,31,33,35) GTZRWABUMPGTQA-UHFFFAOYSA-N 50090538 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL296321 Gonadotropin-releasing hormone receptor Rattus norvegicus 375 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090538 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090538&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 22129998 103989010 CHEMBL296321 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161695 Cc1cc(C)cc(c1)-c1c(OCC[C@@H]2CCCCN2)c2cc(NC(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-11-18(2)13-19(12-17)26-27(39-10-7-20-5-3-4-8-32-20)21-14-24(22(30)15-23(21)34-28(26)37)35-29(38)36-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H2,31,33,35,36,38) IDBKGTFOVFGQBA-UHFFFAOYSA-N 50090556 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrimidin-4-yl-urea::CHEMBL47895 Gonadotropin-releasing hormone receptor Homo sapiens 1.8 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090556 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090556&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293081 103989028 CHEMBL47895 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161696 Clc1ccc(s1)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C25H23Cl2N5O3S/c26-17-12-18-16(11-15(17)24(33)32-21-6-9-28-13-30-21)23(35-10-7-14-3-1-2-8-29-14)22(25(34)31-18)19-4-5-20(27)36-19/h4-6,9,11-14,29H,1-3,7-8,10H2,(H,31,34)(H,28,30,32,33) ZXGMYHMZLYZLFN-UHFFFAOYSA-N 50090543 7-Chloro-3-(5-chloro-thiophen-2-yl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide::CHEMBL48249 Gonadotropin-releasing hormone receptor Homo sapiens 3.9 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090543 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090543&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293284 103989015 CHEMBL48249 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161697 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccccc3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C22H22ClN3O4/c23-17-13-18-16(12-19(17)26(28)29)21(30-11-9-15-8-4-5-10-24-15)20(22(27)25-18)14-6-2-1-3-7-14/h1-3,6-7,12-13,15,24H,4-5,8-11H2,(H,25,27) DNTZLSQWYWUXLZ-UHFFFAOYSA-N 50090557 7-Chloro-6-nitro-3-phenyl-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL46550 Gonadotropin-releasing hormone receptor Rattus norvegicus 410 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090557 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090557&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292608 103989029 CHEMBL46550 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161698 COc1ccc(cc1OC)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C24H26ClN3O6/c1-32-20-7-6-14(11-21(20)33-2)22-23(34-10-8-15-5-3-4-9-26-15)16-12-19(28(30)31)17(25)13-18(16)27-24(22)29/h6-7,11-13,15,26H,3-5,8-10H2,1-2H3,(H,27,29) DGQWBICSABLXJR-UHFFFAOYSA-N 50090560 7-Chloro-3-(3,4-dimethoxy-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL296086 Gonadotropin-releasing hormone receptor Rattus norvegicus 600 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090560 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090560&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292728 103989032 CHEMBL296086 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161700 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)c3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)21-14-24(22(30)15-23(21)34-29(26)37)35-28(36)25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,35,36) YHIBXEIBSOLHKK-UHFFFAOYSA-N 50090558 Pyrazine-2-carboxylic acid [7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-amide::CHEMBL295917 Gonadotropin-releasing hormone receptor Homo sapiens 10 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090558&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293111 103989030 CHEMBL295917 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161701 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccc(Cl)cc3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C22H21Cl2N3O4/c23-14-6-4-13(5-7-14)20-21(31-10-8-15-3-1-2-9-25-15)16-11-19(27(29)30)17(24)12-18(16)26-22(20)28/h4-7,11-12,15,25H,1-3,8-10H2,(H,26,28) JAPKVDPOGKWZBJ-UHFFFAOYSA-N 50090559 7-Chloro-3-(4-chloro-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL48853 Gonadotropin-releasing hormone receptor Rattus norvegicus 160 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090559 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090559&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293062 103989031 CHEMBL48853 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161702 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccsc3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C20H20ClN3O4S/c21-15-10-16-14(9-17(15)24(26)27)19(28-7-4-13-3-1-2-6-22-13)18(20(25)23-16)12-5-8-29-11-12/h5,8-11,13,22H,1-4,6-7H2,(H,23,25) ZCBBUROLDROJNR-UHFFFAOYSA-N 50090563 7-Chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-3-thiophen-3-yl-1H-quinolin-2-one::CHEMBL297768 Gonadotropin-releasing hormone receptor Rattus norvegicus 900 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090563&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292837 103989035 CHEMBL297768 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161703 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3cc(Cl)cc(Cl)c3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C22H20Cl3N3O4/c23-13-7-12(8-14(24)9-13)20-21(32-6-4-15-3-1-2-5-26-15)16-10-19(28(30)31)17(25)11-18(16)27-22(20)29/h7-11,15,26H,1-6H2,(H,27,29) HWLSYBCFIZUFFT-UHFFFAOYSA-N 50090564 7-Chloro-3-(3,5-dichloro-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL300048 Gonadotropin-releasing hormone receptor Rattus norvegicus 24 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090564 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090564&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292661 103989036 CHEMBL300048 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161704 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3cccs3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C20H20ClN3O4S/c21-14-11-15-13(10-16(14)24(26)27)19(28-8-6-12-4-1-2-7-22-12)18(20(25)23-15)17-5-3-9-29-17/h3,5,9-12,22H,1-2,4,6-8H2,(H,23,25) KOHSYYWXDQLZCT-UHFFFAOYSA-N 50090562 7-Chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-3-thiophen-2-yl-1H-quinolin-2-one::CHEMBL48938 Gonadotropin-releasing hormone receptor Rattus norvegicus 220 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090562 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090562&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 9845762 103989034 CHEMBL48938 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161706 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccc4ccccc4c3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C26H24ClN3O4/c27-21-15-22-20(14-23(21)30(32)33)25(34-12-10-19-7-3-4-11-28-19)24(26(31)29-22)18-9-8-16-5-1-2-6-17(16)13-18/h1-2,5-6,8-9,13-15,19,28H,3-4,7,10-12H2,(H,29,31) HYDMAFBYHFZUPZ-UHFFFAOYSA-N 50090565 7-Chloro-3-naphthalen-2-yl-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL47758 Gonadotropin-releasing hormone receptor Rattus norvegicus 53 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090565&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292862 103989037 CHEMBL47758 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161707 Clc1ccc(cc1Cl)-c1c(OCCC2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O InChI=1S/C26H27Cl3N4O3/c27-18-7-4-14(11-19(18)28)23-24(36-10-8-15-3-1-2-9-30-15)17-12-22(33-26(35)31-16-5-6-16)20(29)13-21(17)32-25(23)34/h4,7,11-13,15-16,30H,1-3,5-6,8-10H2,(H,32,34)(H2,31,33,35) ASEOTCOKDIUIKD-UHFFFAOYSA-N 50090566 1-[7-Chloro-3-(3,4-dichloro-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL46060 Gonadotropin-releasing hormone receptor Rattus norvegicus 18 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090566&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292733 103989038 CHEMBL46060 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161709 Cc1cc(ccc1I)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C28H27ClIN5O3/c1-16-12-17(5-6-22(16)30)25-26(38-11-8-18-4-2-3-9-32-18)20-13-19(21(29)14-23(20)34-28(25)37)27(36)35-24-7-10-31-15-33-24/h5-7,10,12-15,18,32H,2-4,8-9,11H2,1H3,(H,34,37)(H,31,33,35,36) OXRVFFHFHVMZJV-UHFFFAOYSA-N 50090542 7-Chloro-3-(4-iodo-3-methyl-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide::CHEMBL48165 Gonadotropin-releasing hormone receptor Homo sapiens 0.500000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090542&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293205 103989014 CHEMBL48165 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161710 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3cccc(Br)c3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C22H21BrClN3O4/c23-14-5-3-4-13(10-14)20-21(31-9-7-15-6-1-2-8-25-15)16-11-19(27(29)30)17(24)12-18(16)26-22(20)28/h3-5,10-12,15,25H,1-2,6-9H2,(H,26,28) UGPJZBWGCKHFDJ-UHFFFAOYSA-N 50090569 3-(3-Bromo-phenyl)-7-chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL45990 Gonadotropin-releasing hormone receptor Rattus norvegicus 40 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090569&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 22130002 103989041 CHEMBL45990 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161711 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-11-18(2)13-19(12-17)26-27(39-10-7-20-5-3-4-8-32-20)21-14-24(22(30)15-23(21)34-28(26)37)35-29(38)36-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H2,31,33,35,36,38) IDBKGTFOVFGQBA-UHFFFAOYSA-N 50090555 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrimidin-4-yl-urea::CHEMBL50433 Gonadotropin-releasing hormone receptor Rattus norvegicus 0.600000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090555&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293163 103989027 CHEMBL50433 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161713 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(C(=O)Nc3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,33,35,36) MSZUEUSSCFWRMD-UHFFFAOYSA-N 50090554 7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid pyrazin-2-ylamide::CHEMBL45883 Gonadotropin-releasing hormone receptor Rattus norvegicus 97 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090554 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090554&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293222 103989026 CHEMBL45883 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161714 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ncccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-12-18(2)14-19(13-17)25-26(39-11-7-20-6-3-4-8-31-20)21-15-24(22(30)16-23(21)34-27(25)37)35-29(38)36-28-32-9-5-10-33-28/h5,9-10,12-16,20,31H,3-4,6-8,11H2,1-2H3,(H,34,37)(H2,32,33,35,36,38) KRIBVWJKLFAVAH-UHFFFAOYSA-N 50090567 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrimidin-2-yl-urea::CHEMBL295911 Gonadotropin-releasing hormone receptor Rattus norvegicus 6 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090567 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090567&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293323 103989039 CHEMBL295911 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161715 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3cc(cc(c3)C(F)(F)F)C(F)(F)F)c(=[OH+])[n-]c2cc1Cl InChI=1S/C24H20ClF6N3O4/c25-17-11-18-16(10-19(17)34(36)37)21(38-6-4-15-3-1-2-5-32-15)20(22(35)33-18)12-7-13(23(26,27)28)9-14(8-12)24(29,30)31/h7-11,15,32H,1-6H2,(H,33,35) YLXXHAUECSGZRB-UHFFFAOYSA-N 50090568 3-(3,5-Bis-trifluoromethyl-phenyl)-7-chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL296198 Gonadotropin-releasing hormone receptor Rattus norvegicus 71 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090568&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293011 103989040 CHEMBL296198 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161716 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)c3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)21-14-24(22(30)15-23(21)34-29(26)37)35-28(36)25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,35,36) YHIBXEIBSOLHKK-UHFFFAOYSA-N 50090558 Pyrazine-2-carboxylic acid [7-chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-amide::CHEMBL295917 Gonadotropin-releasing hormone receptor Rattus norvegicus 1.8 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090558&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293111 103989030 CHEMBL295917 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161717 Clc1cc2[nH]c(=O)c(-c3cccc(Br)c3)c(OCCC3CCCCN3)c2cc1NC(=O)NC1CC1 InChI=1S/C26H28BrClN4O3/c27-16-5-3-4-15(12-16)23-24(35-11-9-17-6-1-2-10-29-17)19-13-22(32-26(34)30-18-7-8-18)20(28)14-21(19)31-25(23)33/h3-5,12-14,17-18,29H,1-2,6-11H2,(H,31,33)(H2,30,32,34) XHJQPYJPAAPTPG-UHFFFAOYSA-N 50090571 1-[3-(3-Bromo-phenyl)-7-chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL46844 Gonadotropin-releasing hormone receptor Rattus norvegicus 6 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090571&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 22129993 103989043 CHEMBL46844 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161720 Cc1ccc(cc1C)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C24H26ClN3O4/c1-14-6-7-16(11-15(14)2)22-23(32-10-8-17-5-3-4-9-26-17)18-12-21(28(30)31)19(25)13-20(18)27-24(22)29/h6-7,11-13,17,26H,3-5,8-10H2,1-2H3,(H,27,29) PRSLJDQAGGFMKK-UHFFFAOYSA-N 50090572 7-Chloro-3-(3,4-dimethyl-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL296819 Gonadotropin-releasing hormone receptor Rattus norvegicus 18 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090572&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293041 103989044 CHEMBL296819 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161721 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccccn3)c(Cl)cc2[nH]c1=O InChI=1S/C30H32ClN5O3/c1-18-13-19(2)15-20(14-18)27-28(39-12-9-21-7-3-5-10-32-21)22-16-25(23(31)17-24(22)34-29(27)37)35-30(38)36-26-8-4-6-11-33-26/h4,6,8,11,13-17,21,32H,3,5,7,9-10,12H2,1-2H3,(H,34,37)(H2,33,35,36,38) SMWNCXKOTUSXIC-UHFFFAOYSA-N 50090570 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyridin-2-yl-urea::CHEMBL295791 Gonadotropin-releasing hormone receptor Rattus norvegicus 15 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090570&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 10209293 103989042 CHEMBL295791 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161722 CCN(CC)Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C28H35ClN4O4/c1-4-32(5-2)17-19-12-18(3)13-20(14-19)26-27(37-11-9-21-8-6-7-10-30-21)22-15-25(33(35)36)23(29)16-24(22)31-28(26)34/h12-16,21,30H,4-11,17H2,1-3H3,(H,31,34) XEUJVNWKYKXWBP-UHFFFAOYSA-N 50090573 7-Chloro-3-(3-diethylaminomethyl-5-methyl-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL47618 Gonadotropin-releasing hormone receptor Rattus norvegicus 270 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090573&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292835 103989045 CHEMBL47618 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161723 Cc1ccc(c(C)c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O |(16.25,-4.21,;14.92,-4.98,;13.58,-4.21,;12.25,-4.98,;12.25,-6.51,;13.58,-7.29,;13.56,-8.83,;14.91,-6.52,;10.9,-7.26,;9.57,-6.49,;9.57,-4.95,;8.24,-4.18,;8.24,-2.64,;6.91,-1.87,;5.58,-2.64,;4.25,-1.87,;4.25,-.33,;5.58,.44,;6.91,-.33,;8.24,-7.26,;6.91,-6.49,;5.58,-7.28,;5.58,-8.82,;4.23,-9.59,;6.91,-9.59,;8.24,-8.8,;9.57,-9.59,;10.9,-8.82,;12.23,-9.59,;4.25,-6.51,;4.25,-4.97,;2.9,-7.28,)| InChI=1S/C24H26ClN3O4/c1-14-6-7-17(15(2)11-14)22-23(32-10-8-16-5-3-4-9-26-16)18-12-21(28(30)31)19(25)13-20(18)27-24(22)29/h6-7,11-13,16,26H,3-5,8-10H2,1-2H3,(H,27,29) YVLQUWQEJHKSBM-UHFFFAOYSA-N 50090575 7-Chloro-3-(2,4-dimethyl-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL46383 Gonadotropin-releasing hormone receptor Rattus norvegicus 400 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090575&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292984 103989047 CHEMBL46383 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161724 Clc1cc2[nH]c(=O)c(-c3ccc4CCCc4c3)c(OCC[C@@H]3CCCCN3)c2cc1C(=O)Nc1ccncn1 InChI=1S/C30H30ClN5O3/c31-24-16-25-23(15-22(24)29(37)36-26-9-12-32-17-34-26)28(39-13-10-21-6-1-2-11-33-21)27(30(38)35-25)20-8-7-18-4-3-5-19(18)14-20/h7-9,12,14-17,21,33H,1-6,10-11,13H2,(H,35,38)(H,32,34,36,37) LDPBFWKHHOZVLX-UHFFFAOYSA-N 50090576 7-Chloro-3-indan-5-yl-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide::CHEMBL48674 Gonadotropin-releasing hormone receptor Homo sapiens 0.700000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090576&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293045 103989048 CHEMBL48674 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161725 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccc(Cl)c(Cl)c3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C22H20Cl3N3O4/c23-15-5-4-12(9-16(15)24)20-21(32-8-6-13-3-1-2-7-26-13)14-10-19(28(30)31)17(25)11-18(14)27-22(20)29/h4-5,9-11,13,26H,1-3,6-8H2,(H,27,29) VSATUVSPDAYJSO-UHFFFAOYSA-N 50090574 7-Chloro-3-(3,4-dichloro-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL296084 Gonadotropin-releasing hormone receptor Rattus norvegicus 29 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090574&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292983 103989046 CHEMBL296084 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161726 Cc1cccc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O InChI=1S/C27H31ClN4O3/c1-16-5-4-6-17(13-16)24-25(35-12-10-18-7-2-3-11-29-18)20-14-23(32-27(34)30-19-8-9-19)21(28)15-22(20)31-26(24)33/h4-6,13-15,18-19,29H,2-3,7-12H2,1H3,(H,31,33)(H2,30,32,34) MNHPUMYSSDXMMN-UHFFFAOYSA-N 50090578 1-[7-Chloro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-3-m-tolyl-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL49695 Gonadotropin-releasing hormone receptor Rattus norvegicus 23 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090578&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292747 103989050 CHEMBL49695 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161727 Cc1cc(CC(N)=O)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C25H27ClN4O5/c1-14-8-15(11-22(27)31)10-16(9-14)23-24(35-7-5-17-4-2-3-6-28-17)18-12-21(30(33)34)19(26)13-20(18)29-25(23)32/h8-10,12-13,17,28H,2-7,11H2,1H3,(H3,27,29,31,32) UWQYWCJKFAINPR-UHFFFAOYSA-N 50090577 2-{3-[7-Chloro-6-nitro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-3-yl]-5-methyl-phenyl}-acetamide::CHEMBL295556 Gonadotropin-releasing hormone receptor Rattus norvegicus 71 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090577&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292820 103989049 CHEMBL295556 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161729 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccc(Cl)s3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C20H19Cl2N3O4S/c21-13-10-14-12(9-15(13)25(27)28)19(29-8-6-11-3-1-2-7-23-11)18(20(26)24-14)16-4-5-17(22)30-16/h4-5,9-11,23H,1-3,6-8H2,(H,24,26) NOQHMKNICUECRI-UHFFFAOYSA-N 50090580 7-Chloro-3-(5-chloro-thiophen-2-yl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL416459 Gonadotropin-releasing hormone receptor Rattus norvegicus 23 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090580&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293126 103989052 CHEMBL416459 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161730 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccncc3)c(Cl)cc2[nH]c1=O InChI=1S/C30H32ClN5O3/c1-18-13-19(2)15-20(14-18)27-28(39-12-8-21-5-3-4-9-33-21)23-16-26(24(31)17-25(23)35-29(27)37)36-30(38)34-22-6-10-32-11-7-22/h6-7,10-11,13-17,21,33H,3-5,8-9,12H2,1-2H3,(H,35,37)(H2,32,34,36,38) CZIIWRLNACPBRE-UHFFFAOYSA-N 50090582 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyridin-4-yl-urea::CHEMBL50120 Gonadotropin-releasing hormone receptor Rattus norvegicus 40 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090582&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 9959121 103989054 CHEMBL50120 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161731 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3cccc(F)c3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C22H21ClFN3O4/c23-17-12-18-16(11-19(17)27(29)30)21(31-9-7-15-6-1-2-8-25-15)20(22(28)26-18)13-4-3-5-14(24)10-13/h3-5,10-12,15,25H,1-2,6-9H2,(H,26,28) IMXZTEMZPQPPBP-UHFFFAOYSA-N 50090581 7-Chloro-3-(3-fluoro-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL298300 Gonadotropin-releasing hormone receptor Rattus norvegicus 53 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090581&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292606 103989053 CHEMBL298300 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161732 CC(O)c1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C25H28ClN3O5/c1-14-9-16(15(2)30)11-17(10-14)23-24(34-8-6-18-5-3-4-7-27-18)19-12-22(29(32)33)20(26)13-21(19)28-25(23)31/h9-13,15,18,27,30H,3-8H2,1-2H3,(H,28,31) JALKFUONYGFTTA-UHFFFAOYSA-N 50090585 7-Chloro-3-[3-(1-hydroxy-ethyl)-5-methyl-phenyl]-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL49276 Gonadotropin-releasing hormone receptor Rattus norvegicus 63 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090585&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293100 103989057 CHEMBL49276 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161733 COc1ccc(cc1C)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C24H26ClN3O5/c1-14-11-15(6-7-21(14)32-2)22-23(33-10-8-16-5-3-4-9-26-16)17-12-20(28(30)31)18(25)13-19(17)27-24(22)29/h6-7,11-13,16,26H,3-5,8-10H2,1-2H3,(H,27,29) CKBXYKNVOLYXGU-UHFFFAOYSA-N 50090584 7-Chloro-3-(4-methoxy-3-methyl-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL46157 Gonadotropin-releasing hormone receptor Rattus norvegicus 40 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090584&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292829 103989056 CHEMBL46157 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161734 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3cccc(Cl)c3)c(=[OH+])[n-]c2cc1Cl InChI=1S/C22H21Cl2N3O4/c23-14-5-3-4-13(10-14)20-21(31-9-7-15-6-1-2-8-25-15)16-11-19(27(29)30)17(24)12-18(16)26-22(20)28/h3-5,10-12,15,25H,1-2,6-9H2,(H,26,28) PFAARKLXCOAHJZ-UHFFFAOYSA-N 50090579 7-Chloro-3-(3-chloro-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL46288 Gonadotropin-releasing hormone receptor Rattus norvegicus 40 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090579&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292621 103989051 CHEMBL46288 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161735 Cc1ccc(cc1C)-c1c(OCCC2CCCCN2)c2cc(NC(=O)NC3CC3)c(Cl)cc2[nH]c1=O InChI=1S/C28H33ClN4O3/c1-16-6-7-18(13-17(16)2)25-26(36-12-10-19-5-3-4-11-30-19)21-14-24(33-28(35)31-20-8-9-20)22(29)15-23(21)32-27(25)34/h6-7,13-15,19-20,30H,3-5,8-12H2,1-2H3,(H,32,34)(H2,31,33,35) JWTNLMHCFUVQFQ-UHFFFAOYSA-N 50090587 1-[7-Chloro-3-(3,4-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea::CHEMBL49667 Gonadotropin-releasing hormone receptor Rattus norvegicus 6 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090587&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44292745 103989059 CHEMBL49667 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161736 CC(C)(C)c1ccc(cc1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C26H30ClN3O4/c1-26(2,3)17-9-7-16(8-10-17)23-24(34-13-11-18-6-4-5-12-28-18)19-14-22(30(32)33)20(27)15-21(19)29-25(23)31/h7-10,14-15,18,28H,4-6,11-13H2,1-3H3,(H,29,31) IEQJCAJJNAKNSJ-UHFFFAOYSA-N 50090589 3-(4-tert-Butyl-phenyl)-7-chloro-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL301552 Gonadotropin-releasing hormone receptor Rattus norvegicus 200 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090589 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090589&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293058 103989061 CHEMBL301552 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161737 Cc1ccc(cc1C)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H30ClN5O3/c1-17-6-7-19(13-18(17)2)26-27(38-12-9-20-5-3-4-10-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-8-11-31-16-33-25/h6-8,11,13-16,20,32H,3-5,9-10,12H2,1-2H3,(H,34,37)(H,31,33,35,36) ZFWDPFBHEBNOQK-UHFFFAOYSA-N 50090588 7-Chloro-3-(3,4-dimethyl-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide::CHEMBL49230 Gonadotropin-releasing hormone receptor Homo sapiens 0.700000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090588&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293206 103989060 CHEMBL49230 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161738 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-11-18(2)13-19(12-17)26-27(39-10-7-20-5-3-4-8-32-20)21-14-24(22(30)15-23(21)34-28(26)37)35-29(38)36-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H2,31,33,35,36,38) IDBKGTFOVFGQBA-UHFFFAOYSA-N 50090555 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrimidin-4-yl-urea::CHEMBL50433 Gonadotropin-releasing hormone receptor Rattus norvegicus 235 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090555&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293163 103989027 CHEMBL50433 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161739 [O-][N+](=O)c1cc2c(OCCC3CCCCN3)c(-c3ccccc3Cl)c(=[OH+])[n-]c2cc1Cl |(4.91,-4.97,;4.91,-6.51,;3.58,-7.28,;6.24,-7.28,;7.57,-6.49,;8.91,-7.26,;10.24,-6.49,;10.24,-4.95,;8.91,-4.18,;8.91,-2.64,;7.57,-1.87,;6.25,-2.64,;4.91,-1.87,;4.92,-.33,;6.26,.44,;7.58,-.33,;11.58,-7.26,;12.91,-6.51,;12.91,-4.98,;14.24,-4.21,;15.59,-4.98,;15.57,-6.52,;14.24,-7.29,;14.24,-8.83,;11.58,-8.82,;12.91,-9.59,;10.24,-9.59,;8.9,-8.8,;7.57,-9.59,;6.24,-8.82,;4.91,-9.59,)| InChI=1S/C22H21Cl2N3O4/c23-16-7-2-1-6-14(16)20-21(31-10-8-13-5-3-4-9-25-13)15-11-19(27(29)30)17(24)12-18(15)26-22(20)28/h1-2,6-7,11-13,25H,3-5,8-10H2,(H,26,28) OEKBDGMSVUJRKC-UHFFFAOYSA-N 50090590 7-Chloro-3-(2-chloro-phenyl)-6-nitro-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL274952 Gonadotropin-releasing hormone receptor Rattus norvegicus 360 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090590&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293085 103989062 CHEMBL274952 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161740 [O-][N+](=O)c1cccc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C22H21ClN4O6/c23-17-12-18-16(11-19(17)27(31)32)21(33-9-7-14-5-1-2-8-24-14)20(22(28)25-18)13-4-3-6-15(10-13)26(29)30/h3-4,6,10-12,14,24H,1-2,5,7-9H2,(H,25,28) UHECQQOCZFEBTH-UHFFFAOYSA-N 50090591 7-Chloro-6-nitro-3-(3-nitro-phenyl)-4-(2-piperidin-2-yl-ethoxy)-1H-quinolin-2-one::CHEMBL45490 Gonadotropin-releasing hormone receptor Rattus norvegicus 100 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090591&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293010 103989063 CHEMBL45490 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50161741 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(C(=O)Nc3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H30ClN5O3/c1-17-11-18(2)13-19(12-17)26-27(38-10-6-20-5-3-4-7-32-20)22-14-21(23(30)15-24(22)34-29(26)37)28(36)35-25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H,33,35,36) MSZUEUSSCFWRMD-UHFFFAOYSA-N 50090554 7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid pyrazin-2-ylamide::CHEMBL45883 Gonadotropin-releasing hormone receptor Homo sapiens 0.900000 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090554 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090554&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293222 103989026 CHEMBL45883 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161742 Clc1ccc(cc1Cl)-c1c(OCC[C@@H]2CCCCN2)c2cc(C(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C27H24Cl3N5O3/c28-19-5-4-15(11-21(19)30)24-25(38-10-7-16-3-1-2-8-32-16)18-12-17(20(29)13-22(18)34-27(24)37)26(36)35-23-6-9-31-14-33-23/h4-6,9,11-14,16,32H,1-3,7-8,10H2,(H,34,37)(H,31,33,35,36) HWDLAHZSNLDSHD-UHFFFAOYSA-N 50090583 7-Chloro-3-(3,4-dichloro-phenyl)-2-oxo-4-((S)-2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid pyrimidin-4-ylamide::CHEMBL45784 Gonadotropin-releasing hormone receptor Homo sapiens 1 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7224&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090583&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293386 103989055 CHEMBL45784 1 MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_HUMAN P30968 O75793 Q14D13 Q92644 50161743 CC(=O)OCc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(c(Cl)cc2[n-]c1=[OH+])[N+]([O-])=O InChI=1S/C26H28ClN3O6/c1-15-9-17(14-36-16(2)31)11-18(10-15)24-25(35-8-6-19-5-3-4-7-28-19)20-12-23(30(33)34)21(27)13-22(20)29-26(24)32/h9-13,19,28H,3-8,14H2,1-2H3,(H,29,32) UXTIHNPTGAMTGF-UHFFFAOYSA-N 50090586 Acetic acid 3-[7-chloro-6-nitro-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-3-yl]-5-methyl-benzyl ester::CHEMBL49162 Gonadotropin-releasing hormone receptor Rattus norvegicus 45 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090586&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293101 103989058 CHEMBL49162 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50580182 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3ccncn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-11-18(2)13-19(12-17)26-27(39-10-7-20-5-3-4-8-32-20)21-14-24(22(30)15-23(21)34-28(26)37)35-29(38)36-25-6-9-31-16-33-25/h6,9,11-16,20,32H,3-5,7-8,10H2,1-2H3,(H,34,37)(H2,31,33,35,36,38) IDBKGTFOVFGQBA-UHFFFAOYSA-N 50090555 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrimidin-4-yl-urea::CHEMBL50433 Gonadotropin-releasing hormone receptor Rattus norvegicus 235 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090555&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293163 103989027 CHEMBL50433 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969 50580183 Cc1cc(C)cc(c1)-c1c(OCCC2CCCCN2)c2cc(NC(=O)Nc3cnccn3)c(Cl)cc2[nH]c1=O InChI=1S/C29H31ClN6O3/c1-17-11-18(2)13-19(12-17)26-27(39-10-6-20-5-3-4-7-32-20)21-14-24(22(30)15-23(21)34-28(26)37)35-29(38)36-25-16-31-8-9-33-25/h8-9,11-16,20,32H,3-7,10H2,1-2H3,(H,34,37)(H2,33,35,36,38) ADRCRSPDCZNNQH-UHFFFAOYSA-N 50090552 1-[7-Chloro-3-(3,5-dimethyl-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-pyrazin-2-yl-urea::CHEMBL50283 Gonadotropin-releasing hormone receptor Rattus norvegicus 56 ChEMBL 10.1016/s0960-894x(00)00318-8 10.7270/Q26W99B2 10937733 Young, JR; Huang, SX; Chen, I; Walsh, TF; DeVita, RJ; Wyvratt, MJ; Goulet, MT; Ren, N; Lo, J; Yang, YT; Yudkovitz, JB; Cheng, K; Smith, RG 12/6/2000 11/10/2009 Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50090552 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000517&target=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50090552&enzyme=Gonadotropin-releasing+hormone+receptor&column=ki&startPg=0&Increment=50&submit=Search 44293301 103989024 CHEMBL50283 1 MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL Gonadotropin-releasing hormone receptor GNRHR_RAT P30969