BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 51570548 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(Cl)cc1 InChI=1S/C25H25ClN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33) RJAHCIRRAPFPSF-UHFFFAOYSA-N 694471 US20240293412, Compound TABLE2.24 Nicotinamide phosphoribosyltransferase Homo sapiens 1070 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694471&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570549 CCc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C27H30N6O/c1-3-20-8-10-21(11-9-20)15-28-27(34)22-5-4-14-32(16-22)26-24-17-33(31-25(24)29-18-30-26)23-12-6-19(2)7-13-23/h6-13,17-18,22H,3-5,14-16H2,1-2H3,(H,28,34) CCBILSQKHWBPBT-UHFFFAOYSA-N 694472 US20240293412, Compound TABLE2.25 Nicotinamide phosphoribosyltransferase Homo sapiens 1400 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694472&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570550 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1cccc(C)c1 InChI=1S/C26H28N6O/c1-18-8-10-22(11-9-18)32-16-23-24(30-32)28-17-29-25(23)31-12-4-7-21(15-31)26(33)27-14-20-6-3-5-19(2)13-20/h3,5-6,8-11,13,16-17,21H,4,7,12,14-15H2,1-2H3,(H,27,33) BJCBYCGXWGPXJQ-UHFFFAOYSA-N 694477 US20240293412, Compound TABLE2.30 Nicotinamide phosphoribosyltransferase Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694477&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570551 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(F)cc1F InChI=1S/C25H24F2N6O/c1-16-4-8-20(9-5-16)33-14-21-23(31-33)29-15-30-24(21)32-10-2-3-18(13-32)25(34)28-12-17-6-7-19(26)11-22(17)27/h4-9,11,14-15,18H,2-3,10,12-13H2,1H3,(H,28,34) JYCUTZNIOGCBCR-UHFFFAOYSA-N 694478 US20240293412, Compound TABLE2.31 Nicotinamide phosphoribosyltransferase Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694478&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570552 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(F)cc1Cl InChI=1S/C25H24ClFN6O/c1-16-4-8-20(9-5-16)33-14-21-23(31-33)29-15-30-24(21)32-10-2-3-18(13-32)25(34)28-12-17-6-7-19(27)11-22(17)26/h4-9,11,14-15,18H,2-3,10,12-13H2,1H3,(H,28,34) SJRIXDNZNCKODI-UHFFFAOYSA-N 694479 US20240293412, Compound TABLE2.32 Nicotinamide phosphoribosyltransferase Homo sapiens 15800 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694479&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570553 Fc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(Cl)cc1 InChI=1S/C24H22ClFN6O/c25-18-5-3-16(4-6-18)12-27-24(33)17-2-1-11-31(13-17)23-21-14-32(30-22(21)28-15-29-23)20-9-7-19(26)8-10-20/h3-10,14-15,17H,1-2,11-13H2,(H,27,33) FFWRMNXQOMQMPD-UHFFFAOYSA-N 50631637 CHEMBL5393934 Nicotinamide phosphoribosyltransferase Homo sapiens 960 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631637&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 53039108 505035971 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570554 CCc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C26H27FN6O/c1-2-18-5-7-19(8-6-18)14-28-26(34)20-4-3-13-32(15-20)25-23-16-33(31-24(23)29-17-30-25)22-11-9-21(27)10-12-22/h5-12,16-17,20H,2-4,13-15H2,1H3,(H,28,34) IQLCXAMVKZMLSL-UHFFFAOYSA-N 50631638 CHEMBL5396283 Nicotinamide phosphoribosyltransferase Homo sapiens 1300 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631638&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 53039110 505035972 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570555 CSc1ccc(CNC(=O)[C@@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C26H28N6OS/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(34-2)12-8-19/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33)/t20-/m1/s1 VWUOWUZLQDJSCV-HXUWFJFHSA-N 694467 US20240293412, Compound TABLE2.20 Nicotinamide phosphoribosyltransferase Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694467&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search TIE 8DSC 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570556 CSc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C26H28N6OS/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(34-2)12-8-19/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33)/t20-/m0/s1 VWUOWUZLQDJSCV-FQEVSTJZSA-N 694468 US20240293412, Compound TABLE2.21 Nicotinamide phosphoribosyltransferase Homo sapiens 1000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694468&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search TIW 8DSD 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570557 COC(=O)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(SC)cc1 InChI=1S/C27H28N6O3S/c1-36-27(35)19-7-9-21(10-8-19)33-16-23-24(31-33)29-17-30-25(23)32-13-3-4-20(15-32)26(34)28-14-18-5-11-22(37-2)12-6-18/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,28,34) SSQCTASAALQWNS-UHFFFAOYSA-N 694448 US20240293412, Compound TABLE2.1 Nicotinamide phosphoribosyltransferase Homo sapiens 786 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694448&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570558 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C26H27FN6OS/c1-17-5-8-20(12-23(17)27)33-15-22-24(31-33)29-16-30-25(22)32-11-3-4-19(14-32)26(34)28-13-18-6-9-21(35-2)10-7-18/h5-10,12,15-16,19H,3-4,11,13-14H2,1-2H3,(H,28,34) BVMLQGGCAZPZLK-UHFFFAOYSA-N 694451 US20240293412, Compound TABLE2.4 Nicotinamide phosphoribosyltransferase Homo sapiens 11 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694451&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570559 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2cccc(C)c2)cc1 InChI=1S/C26H28N6OS/c1-18-5-3-7-21(13-18)32-16-23-24(30-32)28-17-29-25(23)31-12-4-6-20(15-31)26(33)27-14-19-8-10-22(34-2)11-9-19/h3,5,7-11,13,16-17,20H,4,6,12,14-15H2,1-2H3,(H,27,33) MOFLQXAGMRXGFI-UHFFFAOYSA-N 694455 US20240293412, Compound TABLE2.8 Nicotinamide phosphoribosyltransferase Homo sapiens 1120 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694455&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570560 CSc1ccc(cc1)[C@H](C)NC(=O)[C@@H]1CCCN(C1)c1ncnc2nn(cc12)-c1ccc(C)cc1 InChI=1S/C27H30N6OS/c1-18-6-10-22(11-7-18)33-16-24-25(31-33)28-17-29-26(24)32-14-4-5-21(15-32)27(34)30-19(2)20-8-12-23(35-3)13-9-20/h6-13,16-17,19,21H,4-5,14-15H2,1-3H3,(H,30,34)/t19-,21+/m0/s1 TVSWAZJEAZRITM-PZJWPPBQSA-N 694456 US20240293412, Compound TABLE2.9 Nicotinamide phosphoribosyltransferase Homo sapiens 2030 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694456&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570561 CSc1ccc(cc1)[C@H](C)NC(=O)[C@H]1CCCN(C1)c1ncnc2nn(cc12)-c1ccc(C)cc1 InChI=1S/C27H30N6OS/c1-18-6-10-22(11-7-18)33-16-24-25(31-33)28-17-29-26(24)32-14-4-5-21(15-32)27(34)30-19(2)20-8-12-23(35-3)13-9-20/h6-13,16-17,19,21H,4-5,14-15H2,1-3H3,(H,30,34)/t19-,21-/m0/s1 TVSWAZJEAZRITM-FPOVZHCZSA-N 694458 US20240293412, Compound TABLE2.11 Nicotinamide phosphoribosyltransferase Homo sapiens 2150 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694458&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570562 CSc1ccc(cc1)[C@@H](C)NC(=O)[C@@H]1CCCN(C1)c1ncnc2nn(cc12)-c1ccc(C)cc1 InChI=1S/C27H30N6OS/c1-18-6-10-22(11-7-18)33-16-24-25(31-33)28-17-29-26(24)32-14-4-5-21(15-32)27(34)30-19(2)20-8-12-23(35-3)13-9-20/h6-13,16-17,19,21H,4-5,14-15H2,1-3H3,(H,30,34)/t19-,21-/m1/s1 TVSWAZJEAZRITM-TZIWHRDSSA-N 694457 US20240293412, Compound TABLE2.10 Nicotinamide phosphoribosyltransferase Homo sapiens 1000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694457&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570563 CSc1ccc(cc1)[C@@H](C)NC(=O)[C@H]1CCCN(C1)c1ncnc2nn(cc12)-c1ccc(C)cc1 InChI=1S/C27H30N6OS/c1-18-6-10-22(11-7-18)33-16-24-25(31-33)28-17-29-26(24)32-14-4-5-21(15-32)27(34)30-19(2)20-8-12-23(35-3)13-9-20/h6-13,16-17,19,21H,4-5,14-15H2,1-3H3,(H,30,34)/t19-,21+/m1/s1 TVSWAZJEAZRITM-CTNGQTDRSA-N 694459 US20240293412, Compound TABLE2.12 Nicotinamide phosphoribosyltransferase Homo sapiens 3160 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694459&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570564 CSc1ccc(CNC(=O)[C@@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C26H27FN6OS/c1-17-5-8-20(12-23(17)27)33-15-22-24(31-33)29-16-30-25(22)32-11-3-4-19(14-32)26(34)28-13-18-6-9-21(35-2)10-7-18/h5-10,12,15-16,19H,3-4,11,13-14H2,1-2H3,(H,28,34)/t19-/m1/s1 BVMLQGGCAZPZLK-LJQANCHMSA-N 694452 US20240293412, Compound TABLE2.5 Nicotinamide phosphoribosyltransferase Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694452&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570565 CSc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C26H27FN6OS/c1-17-5-8-20(12-23(17)27)33-15-22-24(31-33)29-16-30-25(22)32-11-3-4-19(14-32)26(34)28-13-18-6-9-21(35-2)10-7-18/h5-10,12,15-16,19H,3-4,11,13-14H2,1-2H3,(H,28,34)/t19-/m0/s1 BVMLQGGCAZPZLK-IBGZPJMESA-N 694453 US20240293412, Compound TABLE2.6 Nicotinamide phosphoribosyltransferase Homo sapiens 180 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694453&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570566 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(O)cc2)cc1 InChI=1S/C25H26N6O2S/c1-34-21-10-4-17(5-11-21)13-26-25(33)18-3-2-12-30(14-18)24-22-15-31(29-23(22)27-16-28-24)19-6-8-20(32)9-7-19/h4-11,15-16,18,32H,2-3,12-14H2,1H3,(H,26,33) JIWYEFXZMBCIIH-UHFFFAOYSA-N 694462 US20240293412, Compound TABLE2.15 Nicotinamide phosphoribosyltransferase Homo sapiens 8700 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694462&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570567 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccccc2)cc1 InChI=1S/C25H26N6OS/c1-33-21-11-9-18(10-12-21)14-26-25(32)19-6-5-13-30(15-19)24-22-16-31(20-7-3-2-4-8-20)29-23(22)27-17-28-24/h2-4,7-12,16-17,19H,5-6,13-15H2,1H3,(H,26,32) YBGJWKYWOKTFNI-UHFFFAOYSA-N 694463 US20240293412, Compound TABLE2.16 Nicotinamide phosphoribosyltransferase Homo sapiens 2100 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694463&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570568 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(Br)cc2)cc1 InChI=1S/C25H25BrN6OS/c1-34-21-10-4-17(5-11-21)13-27-25(33)18-3-2-12-31(14-18)24-22-15-32(30-23(22)28-16-29-24)20-8-6-19(26)7-9-20/h4-11,15-16,18H,2-3,12-14H2,1H3,(H,27,33) KAPQCHJAWKAAKT-UHFFFAOYSA-N 694464 US20240293412, Compound TABLE2.17 Nicotinamide phosphoribosyltransferase Homo sapiens 81 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694464&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570569 CSc1ccc(CNC(=O)[C@@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C26H25F3N6OS/c1-37-21-10-4-17(5-11-21)13-30-25(36)18-3-2-12-34(14-18)24-22-15-35(33-23(22)31-16-32-24)20-8-6-19(7-9-20)26(27,28)29/h4-11,15-16,18H,2-3,12-14H2,1H3,(H,30,36)/t18-/m1/s1 DBSWYQCSXRNOMX-GOSISDBHSA-N 50631639 CHEMBL5433160 Nicotinamide phosphoribosyltransferase Homo sapiens 65 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631639&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406729 505035973 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570570 CSc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C26H25F3N6OS/c1-37-21-10-4-17(5-11-21)13-30-25(36)18-3-2-12-34(14-18)24-22-15-35(33-23(22)31-16-32-24)20-8-6-19(7-9-20)26(27,28)29/h4-11,15-16,18H,2-3,12-14H2,1H3,(H,30,36)/t18-/m0/s1 DBSWYQCSXRNOMX-SFHVURJKSA-N 50631640 CHEMBL5396979 Nicotinamide phosphoribosyltransferase Homo sapiens 510 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631640&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406489 505035974 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570571 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H25FN6OS/c1-34-21-10-4-17(5-11-21)13-27-25(33)18-3-2-12-31(14-18)24-22-15-32(30-23(22)28-16-29-24)20-8-6-19(26)7-9-20/h4-11,15-16,18H,2-3,12-14H2,1H3,(H,27,33) DTUSZHLRRMMBOD-UHFFFAOYSA-N 50631641 CHEMBL5413979 Nicotinamide phosphoribosyltransferase Homo sapiens 1070 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631641&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406790 505035975 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570572 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@H](C1)C(=O)NCc1ccc(Br)cc1 InChI=1S/C25H25BrN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33)/t19-/m1/s1 GEMKHIOGDNIYKW-LJQANCHMSA-N 694449 US20240293412, Compound TABLE2.2 Nicotinamide phosphoribosyltransferase Homo sapiens 1380 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694449&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570573 Brc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(Br)cc2)cc1 InChI=1S/C24H22Br2N6O/c25-18-5-3-16(4-6-18)12-27-24(33)17-2-1-11-31(13-17)23-21-14-32(30-22(21)28-15-29-23)20-9-7-19(26)8-10-20/h3-10,14-15,17H,1-2,11-13H2,(H,27,33) ZOYOSXSKEOBXQK-UHFFFAOYSA-N 694465 US20240293412, Compound TABLE2.18 Nicotinamide phosphoribosyltransferase Homo sapiens 199 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694465&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570574 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc(Br)cc1 InChI=1S/C25H25BrN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33)/t19-/m0/s1 GEMKHIOGDNIYKW-IBGZPJMESA-N 694450 US20240293412, Compound TABLE2.3 Nicotinamide phosphoribosyltransferase Homo sapiens 4600 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694450&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570575 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(Br)cc1 InChI=1S/C25H24BrFN6O/c1-16-4-9-20(11-22(16)27)33-14-21-23(31-33)29-15-30-24(21)32-10-2-3-18(13-32)25(34)28-12-17-5-7-19(26)8-6-17/h4-9,11,14-15,18H,2-3,10,12-13H2,1H3,(H,28,34) IZUVOQRKOHMQEY-UHFFFAOYSA-N 694454 US20240293412, Compound TABLE2.7 Nicotinamide phosphoribosyltransferase Homo sapiens 118 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694454&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570576 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(Br)cc1 InChI=1S/C25H25BrN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33) GEMKHIOGDNIYKW-UHFFFAOYSA-N 50631642 CHEMBL5427182 Nicotinamide phosphoribosyltransferase Homo sapiens 280 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631642&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406784 505035976 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570577 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc(Br)cc1F InChI=1S/C25H23BrF2N6O/c1-15-4-7-19(10-21(15)27)34-13-20-23(32-34)30-14-31-24(20)33-8-2-3-17(12-33)25(35)29-11-16-5-6-18(26)9-22(16)28/h4-7,9-10,13-14,17H,2-3,8,11-12H2,1H3,(H,29,35)/t17-/m0/s1 KQRVBLRRDUCNLQ-KRWDZBQOSA-N 50631643 CHEMBL5437693 Nicotinamide phosphoribosyltransferase Homo sapiens 460 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631643 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631643&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406800 505035977 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570578 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1c(F)cc(Br)cc1F InChI=1S/C25H22BrF3N6O/c1-14-4-5-17(9-20(14)27)35-12-19-23(33-35)31-13-32-24(19)34-6-2-3-15(11-34)25(36)30-10-18-21(28)7-16(26)8-22(18)29/h4-5,7-9,12-13,15H,2-3,6,10-11H2,1H3,(H,30,36)/t15-/m0/s1 GHOPKYAEYOHJBO-HNNXBMFYSA-N 50631644 CHEMBL5420229 Nicotinamide phosphoribosyltransferase Homo sapiens 495 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631644 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631644&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406619 505035978 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570579 COc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C26H28N6O2/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(34-2)12-8-19/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33) GXMOJHFTBNRRGM-UHFFFAOYSA-N 50631645 CHEMBL5399360 Nicotinamide phosphoribosyltransferase Homo sapiens 1100 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631645&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 50819661 505035979 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570580 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(I)cc1 InChI=1S/C25H25IN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33) SBTXPPRAOJSXSO-UHFFFAOYSA-N 694470 US20240293412, Compound TABLE2.23 Nicotinamide phosphoribosyltransferase Homo sapiens 400 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694470&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570581 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(cc1)S(C)(=O)=O InChI=1S/C26H28N6O3S/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(12-8-19)36(2,34)35/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33) RGMDZARKXXWNDS-UHFFFAOYSA-N 694476 US20240293412, Compound TABLE2.29 Nicotinamide phosphoribosyltransferase Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694476&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570582 CC(=O)c1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C27H28N6O2/c1-18-5-11-23(12-6-18)33-16-24-25(31-33)29-17-30-26(24)32-13-3-4-22(15-32)27(35)28-14-20-7-9-21(10-8-20)19(2)34/h5-12,16-17,22H,3-4,13-15H2,1-2H3,(H,28,35) GMHQCMJIOKCBAZ-UHFFFAOYSA-N 694473 US20240293412, Compound TABLE2.26 Nicotinamide phosphoribosyltransferase Homo sapiens 2600 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694473&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570583 C[S+]([O-])c1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C26H28N6O2S/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(12-8-19)35(2)34/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33) IAIPPANZBRWUJT-UHFFFAOYSA-N 50631646 CHEMBL5414936 Nicotinamide phosphoribosyltransferase Homo sapiens >20000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631646&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406832 505035980 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570584 COC(=O)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc(SC)cc1 InChI=1S/C27H28N6O3S/c1-36-27(35)19-7-9-21(10-8-19)33-16-23-24(31-33)29-17-30-25(23)32-13-3-4-20(15-32)26(34)28-14-18-5-11-22(37-2)12-6-18/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,28,34)/t20-/m0/s1 SSQCTASAALQWNS-FQEVSTJZSA-N 50631647 CHEMBL5407827 Nicotinamide phosphoribosyltransferase Homo sapiens 184 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631647 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631647&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 172447777 505035981 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570585 CSc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(CO)cc2)cc1 InChI=1S/C26H28N6O2S/c1-35-22-10-6-18(7-11-22)13-27-26(34)20-3-2-12-31(14-20)25-23-15-32(30-24(23)28-17-29-25)21-8-4-19(16-33)5-9-21/h4-11,15,17,20,33H,2-3,12-14,16H2,1H3,(H,27,34)/t20-/m0/s1 DIOSHJCPGOFTBT-FQEVSTJZSA-N 50631648 CHEMBL5424819 Nicotinamide phosphoribosyltransferase Homo sapiens 313 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631648 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631648&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 172458305 505035982 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570586 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C27H25FN6OS/c1-17-4-6-21(12-23(17)28)34-15-22-25(32-34)30-16-31-26(22)33-9-2-3-20(14-33)27(35)29-13-18-5-7-24-19(11-18)8-10-36-24/h4-8,10-12,15-16,20H,2-3,9,13-14H2,1H3,(H,29,35)/t20-/m1/s1 LQSRIPAMJVTBAV-HXUWFJFHSA-N 694460 US20240293412, Compound TABLE2.13 Nicotinamide phosphoribosyltransferase Homo sapiens 47 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694460&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570587 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C27H25FN6OS/c1-17-4-6-21(12-23(17)28)34-15-22-25(32-34)30-16-31-26(22)33-9-2-3-20(14-33)27(35)29-13-18-5-7-24-19(11-18)8-10-36-24/h4-8,10-12,15-16,20H,2-3,9,13-14H2,1H3,(H,29,35)/t20-/m0/s1 LQSRIPAMJVTBAV-FQEVSTJZSA-N 694461 US20240293412, Compound TABLE2.14 Nicotinamide phosphoribosyltransferase Homo sapiens 186 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694461&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search XI3 8F7L 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570588 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C27H23F3N6OS/c28-27(29,30)20-4-6-21(7-5-20)36-15-22-24(34-36)32-16-33-25(22)35-10-1-2-19(14-35)26(37)31-13-17-3-8-23-18(12-17)9-11-38-23/h3-9,11-12,15-16,19H,1-2,10,13-14H2,(H,31,37)/t19-/m1/s1 RPVUYLFRBVBINJ-LJQANCHMSA-N 50631649 CHEMBL5431721 Nicotinamide phosphoribosyltransferase Homo sapiens 40 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631649&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406582 505035983 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570589 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C27H23F3N6OS/c28-27(29,30)20-4-6-21(7-5-20)36-15-22-24(34-36)32-16-33-25(22)35-10-1-2-19(14-35)26(37)31-13-17-3-8-23-18(12-17)9-11-38-23/h3-9,11-12,15-16,19H,1-2,10,13-14H2,(H,31,37)/t19-/m0/s1 RPVUYLFRBVBINJ-IBGZPJMESA-N 50631650 CHEMBL5396153 Nicotinamide phosphoribosyltransferase Homo sapiens 120 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631650&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search TKF 8DTJ 165406683 505035984 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570590 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1csc2ccccc12 InChI=1S/C27H25FN6OS/c1-17-8-9-20(11-23(17)28)34-14-22-25(32-34)30-16-31-26(22)33-10-4-5-18(13-33)27(35)29-12-19-15-36-24-7-3-2-6-21(19)24/h2-3,6-9,11,14-16,18H,4-5,10,12-13H2,1H3,(H,29,35)/t18-/m0/s1 HWTYDHVEVWPEJE-SFHVURJKSA-N 50631651 CHEMBL5437194 Nicotinamide phosphoribosyltransferase Homo sapiens 390 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631651 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631651&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406685 505035985 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570591 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1cc2cc(F)ccc2s1 InChI=1S/C27H24F2N6OS/c1-16-4-6-20(11-23(16)29)35-14-22-25(33-35)31-15-32-26(22)34-8-2-3-17(13-34)27(36)30-12-21-10-18-9-19(28)5-7-24(18)37-21/h4-7,9-11,14-15,17H,2-3,8,12-13H2,1H3,(H,30,36)/t17-/m0/s1 MEYWLYXPDZKBLW-KRWDZBQOSA-N 50631652 CHEMBL5421976 Nicotinamide phosphoribosyltransferase Homo sapiens 50 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631652&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406571 505035986 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570592 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2[nH]ccc2c1 InChI=1S/C27H26FN7O/c1-17-4-6-21(12-23(17)28)35-15-22-25(33-35)31-16-32-26(22)34-10-2-3-20(14-34)27(36)30-13-18-5-7-24-19(11-18)8-9-29-24/h4-9,11-12,15-16,20,29H,2-3,10,13-14H2,1H3,(H,30,36)/t20-/m0/s1 XXKUVEJIXZKSAQ-FQEVSTJZSA-N 50631653 CHEMBL5403615 Nicotinamide phosphoribosyltransferase Homo sapiens 5410 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631653&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406748 505035987 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570593 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2ncccc2c1 InChI=1S/C28H26FN7O/c1-18-6-8-22(13-24(18)29)36-16-23-26(34-36)32-17-33-27(23)35-11-3-5-21(15-35)28(37)31-14-19-7-9-25-20(12-19)4-2-10-30-25/h2,4,6-10,12-13,16-17,21H,3,5,11,14-15H2,1H3,(H,31,37)/t21-/m0/s1 BSVHAHLLYZTCMX-NRFANRHFSA-N 50631654 CHEMBL5438473 Nicotinamide phosphoribosyltransferase Homo sapiens 4500 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631654&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 172470018 505035988 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570594 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2scnc2c1 InChI=1S/C26H24FN7OS/c1-16-4-6-19(10-21(16)27)34-13-20-24(32-34)29-14-30-25(20)33-8-2-3-18(12-33)26(35)28-11-17-5-7-23-22(9-17)31-15-36-23/h4-7,9-10,13-15,18H,2-3,8,11-12H2,1H3,(H,28,35)/t18-/m0/s1 UVZZGKGSJXBEFL-SFHVURJKSA-N 50631655 CHEMBL5399677 Nicotinamide phosphoribosyltransferase Homo sapiens 264 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631655&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 167205766 505035989 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570595 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2scnc2c1 InChI=1S/C26H22F3N7OS/c27-26(28,29)18-4-6-19(7-5-18)36-13-20-23(34-36)31-14-32-24(20)35-9-1-2-17(12-35)25(37)30-11-16-3-8-22-21(10-16)33-15-38-22/h3-8,10,13-15,17H,1-2,9,11-12H2,(H,30,37)/t17-/m0/s1 LFURAXQVTFLOLB-KRWDZBQOSA-N 50631656 CHEMBL5410113 Nicotinamide phosphoribosyltransferase Homo sapiens 4034 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631656 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631656&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406828 505035990 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570596 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1c[nH]c2ccccc12 InChI=1S/C27H26FN7O/c1-17-8-9-20(11-23(17)28)35-15-22-25(33-35)31-16-32-26(22)34-10-4-5-18(14-34)27(36)30-13-19-12-29-24-7-3-2-6-21(19)24/h2-3,6-9,11-12,15-16,18,29H,4-5,10,13-14H2,1H3,(H,30,36)/t18-/m0/s1 JWPHHKCMKMDFON-SFHVURJKSA-N 50631657 CHEMBL5405691 Nicotinamide phosphoribosyltransferase Homo sapiens 3557 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631657&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406852 505035991 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570597 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1cc2ccccc2[nH]1 InChI=1S/C27H26FN7O/c1-17-8-9-21(12-23(17)28)35-15-22-25(33-35)30-16-31-26(22)34-10-4-6-19(14-34)27(36)29-13-20-11-18-5-2-3-7-24(18)32-20/h2-3,5,7-9,11-12,15-16,19,32H,4,6,10,13-14H2,1H3,(H,29,36)/t19-/m0/s1 KEXCTXHAIIENRE-IBGZPJMESA-N 50631658 CHEMBL5426674 Nicotinamide phosphoribosyltransferase Homo sapiens 355 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631658&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406538 505035992 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570598 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1cc2cc(Cl)ccc2[nH]1 InChI=1S/C27H25ClFN7O/c1-16-4-6-21(11-23(16)29)36-14-22-25(34-36)31-15-32-26(22)35-8-2-3-17(13-35)27(37)30-12-20-10-18-9-19(28)5-7-24(18)33-20/h4-7,9-11,14-15,17,33H,2-3,8,12-13H2,1H3,(H,30,37)/t17-/m0/s1 OWFSUGXKSDDWTL-KRWDZBQOSA-N 50631659 CHEMBL5438787 Nicotinamide phosphoribosyltransferase Homo sapiens 115 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631659&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406578 505035993 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570599 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1cccnc1 InChI=1S/C24H25N7O/c1-17-6-8-20(9-7-17)31-15-21-22(29-31)27-16-28-23(21)30-11-3-5-19(14-30)24(32)26-13-18-4-2-10-25-12-18/h2,4,6-10,12,15-16,19H,3,5,11,13-14H2,1H3,(H,26,32) OJMPHPDVYHBNJG-UHFFFAOYSA-N 50631660 CHEMBL5396898 Nicotinamide phosphoribosyltransferase Homo sapiens >10000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631660&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 172440385 505035994 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570600 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC(C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C26H23FN6OS/c1-16-2-4-20(11-22(16)27)33-14-21-24(31-33)29-15-30-25(21)32-8-6-19(13-32)26(34)28-12-17-3-5-23-18(10-17)7-9-35-23/h2-5,7,9-11,14-15,19H,6,8,12-13H2,1H3,(H,28,34) CBYHAEJFNJOBTL-UHFFFAOYSA-N 50631661 CHEMBL5405783 Nicotinamide phosphoribosyltransferase Homo sapiens 620 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631661&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406820 505035995 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570601 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC(C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C26H21F3N6OS/c27-26(28,29)19-2-4-20(5-3-19)35-14-21-23(33-35)31-15-32-24(21)34-9-7-18(13-34)25(36)30-12-16-1-6-22-17(11-16)8-10-37-22/h1-6,8,10-11,14-15,18H,7,9,12-13H2,(H,30,36) ALAPWZOIZKOLAL-UHFFFAOYSA-N 50631662 CHEMBL5400470 Nicotinamide phosphoribosyltransferase Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631662 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631662&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406873 505035996 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570602 CSc1ccc(CNC(=O)C2CCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C25H25FN6OS/c1-16-3-6-19(11-22(16)26)32-14-21-23(30-32)28-15-29-24(21)31-10-9-18(13-31)25(33)27-12-17-4-7-20(34-2)8-5-17/h3-8,11,14-15,18H,9-10,12-13H2,1-2H3,(H,27,33) GAAVPXCBTWQRMY-UHFFFAOYSA-N 50631663 CHEMBL5437419 Nicotinamide phosphoribosyltransferase Homo sapiens 720 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631663&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406583 505035997 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570603 CSc1ccc(CNC(=O)C2CCN(C2)c2ncnc3nn(cc23)-c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C25H23F3N6OS/c1-36-20-8-2-16(3-9-20)12-29-24(35)17-10-11-33(13-17)23-21-14-34(32-22(21)30-15-31-23)19-6-4-18(5-7-19)25(26,27)28/h2-9,14-15,17H,10-13H2,1H3,(H,29,35) USHRJUAYWFFMMJ-UHFFFAOYSA-N 50631664 CHEMBL5438797 Nicotinamide phosphoribosyltransferase Homo sapiens 2500 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631664&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406926 505035998 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570604 CN1CCN(C[C@H]1C(=O)NCc1ccc2sccc2c1)c1ncnc2nn(cc12)-c1ccc(cc1)C(F)(F)F InChI=1S/C27H24F3N7OS/c1-35-9-10-36(15-22(35)26(38)31-13-17-2-7-23-18(12-17)8-11-39-23)25-21-14-37(34-24(21)32-16-33-25)20-5-3-19(4-6-20)27(28,29)30/h2-8,11-12,14,16,22H,9-10,13,15H2,1H3,(H,31,38)/t22-/m0/s1 ZXBNPADWSUISJZ-QFIPXVFZSA-N 694485 US20240293412, Compound TABLE2.38 Nicotinamide phosphoribosyltransferase Homo sapiens 99 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694485&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570605 CN1CCN(C[C@H]1C(=O)NCc1ccc2sccc2c1)c1ncnc2nn(cc12)-c1ccc(C)c(F)c1 InChI=1S/C27H26FN7OS/c1-17-3-5-20(12-22(17)28)35-14-21-25(32-35)30-16-31-26(21)34-9-8-33(2)23(15-34)27(36)29-13-18-4-6-24-19(11-18)7-10-37-24/h3-7,10-12,14,16,23H,8-9,13,15H2,1-2H3,(H,29,36)/t23-/m0/s1 XQQWDPYKSGUYNU-QHCPKHFHSA-N 694483 US20240293412, Compound TABLE2.36 Nicotinamide phosphoribosyltransferase Homo sapiens 18 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694483&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570606 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCN[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C26H24FN7OS/c1-16-2-4-19(11-21(16)27)34-13-20-24(32-34)30-15-31-25(20)33-8-7-28-22(14-33)26(35)29-12-17-3-5-23-18(10-17)6-9-36-23/h2-6,9-11,13,15,22,28H,7-8,12,14H2,1H3,(H,29,35)/t22-/m0/s1 BPWFZVHRVMSJIY-QFIPXVFZSA-N 694482 US20240293412, Compound TABLE2.35 Nicotinamide phosphoribosyltransferase Homo sapiens 15 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694482&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570607 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCN[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C26H22F3N7OS/c27-26(28,29)18-2-4-19(5-3-18)36-13-20-23(34-36)32-15-33-24(20)35-9-8-30-21(14-35)25(37)31-12-16-1-6-22-17(11-16)7-10-38-22/h1-7,10-11,13,15,21,30H,8-9,12,14H2,(H,31,37)/t21-/m0/s1 PNEQDEPNUMZDMO-NRFANRHFSA-N 694484 US20240293412, Compound TABLE2.37 Nicotinamide phosphoribosyltransferase Homo sapiens 58 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694484&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570608 CN(CCC(=O)NCc1ccc2sccc2c1)c1ncnc2nn(cc12)-c1ccc(C)c(F)c1 InChI=1S/C25H23FN6OS/c1-16-3-5-19(12-21(16)26)32-14-20-24(30-32)28-15-29-25(20)31(2)9-7-23(33)27-13-17-4-6-22-18(11-17)8-10-34-22/h3-6,8,10-12,14-15H,7,9,13H2,1-2H3,(H,27,33) UZISDMSLWIXCAE-UHFFFAOYSA-N 50631665 CHEMBL5425220 Nicotinamide phosphoribosyltransferase Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631665&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406864 505035999 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570609 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCCC(CC1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C28H27FN6OS/c1-18-4-6-22(14-24(18)29)35-16-23-26(33-35)31-17-32-27(23)34-10-2-3-20(8-11-34)28(36)30-15-19-5-7-25-21(13-19)9-12-37-25/h4-7,9,12-14,16-17,20H,2-3,8,10-11,15H2,1H3,(H,30,36) NXKMBZJCLDIZNY-UHFFFAOYSA-N 50631666 CHEMBL5429514 Nicotinamide phosphoribosyltransferase Homo sapiens 25 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631666&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406528 505036000 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570610 Cc1ccc(cc1)-c1cc2c(ncnc2s1)N1CCC[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C28H26N4OS2/c1-18-4-7-20(8-5-18)25-14-23-26(30-17-31-28(23)35-25)32-11-2-3-22(16-32)27(33)29-15-19-6-9-24-21(13-19)10-12-34-24/h4-10,12-14,17,22H,2-3,11,15-16H2,1H3,(H,29,33)/t22-/m0/s1 IOQQRDFJTAYCMW-QFIPXVFZSA-N 50631667 CHEMBL5410531 Nicotinamide phosphoribosyltransferase Homo sapiens 76 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631667 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631667&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406684 505036001 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570611 Cc1ccc(cc1F)-c1cc2c(ncnc2s1)N1CCC[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C28H25FN4OS2/c1-17-4-6-19(12-23(17)29)25-13-22-26(31-16-32-28(22)36-25)33-9-2-3-21(15-33)27(34)30-14-18-5-7-24-20(11-18)8-10-35-24/h4-8,10-13,16,21H,2-3,9,14-15H2,1H3,(H,30,34)/t21-/m0/s1 XOPCXLZFJYPEAF-NRFANRHFSA-N 50631668 CHEMBL5402281 Nicotinamide phosphoribosyltransferase Homo sapiens 47 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631668&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 167205581 505036002 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570612 CSc1ccc(NNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C25H26FN7OS/c1-16-5-8-19(12-22(16)26)33-14-21-23(31-33)27-15-28-24(21)32-11-3-4-17(13-32)25(34)30-29-18-6-9-20(35-2)10-7-18/h5-10,12,14-15,17,29H,3-4,11,13H2,1-2H3,(H,30,34)/t17-/m0/s1 BGQBBSQXZCZKCL-KRWDZBQOSA-N 50631669 CHEMBL5440080 Nicotinamide phosphoribosyltransferase Homo sapiens 6880 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631669 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631669&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 172471881 505036003 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570613 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NNc1ccc2sccc2c1 InChI=1S/C26H24FN7OS/c1-16-4-6-20(12-22(16)27)34-14-21-24(32-34)28-15-29-25(21)33-9-2-3-18(13-33)26(35)31-30-19-5-7-23-17(11-19)8-10-36-23/h4-8,10-12,14-15,18,30H,2-3,9,13H2,1H3,(H,31,35)/t18-/m0/s1 UIXNJNXIGGERSV-SFHVURJKSA-N 50631670 CHEMBL5398137 Nicotinamide phosphoribosyltransferase Homo sapiens 753 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631670 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631670&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 172441535 505036004 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570614 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(Cl)cc1 InChI=1S/C25H25ClN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33) RJAHCIRRAPFPSF-UHFFFAOYSA-N 694471 US20240293412, Compound TABLE2.24 Nicotinamide phosphoribosyltransferase Homo sapiens 1290 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694471&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570615 CCc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C27H30N6O/c1-3-20-8-10-21(11-9-20)15-28-27(34)22-5-4-14-32(16-22)26-24-17-33(31-25(24)29-18-30-26)23-12-6-19(2)7-13-23/h6-13,17-18,22H,3-5,14-16H2,1-2H3,(H,28,34) CCBILSQKHWBPBT-UHFFFAOYSA-N 694472 US20240293412, Compound TABLE2.25 Nicotinamide phosphoribosyltransferase Homo sapiens 2220 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694472&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570616 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1cccc(C)c1 InChI=1S/C26H28N6O/c1-18-8-10-22(11-9-18)32-16-23-24(30-32)28-17-29-25(23)31-12-4-7-21(15-31)26(33)27-14-20-6-3-5-19(2)13-20/h3,5-6,8-11,13,16-17,21H,4,7,12,14-15H2,1-2H3,(H,27,33) BJCBYCGXWGPXJQ-UHFFFAOYSA-N 694477 US20240293412, Compound TABLE2.30 Nicotinamide phosphoribosyltransferase Homo sapiens 18100 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694477&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570617 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(F)cc1F InChI=1S/C25H24F2N6O/c1-16-4-8-20(9-5-16)33-14-21-23(31-33)29-15-30-24(21)32-10-2-3-18(13-32)25(34)28-12-17-6-7-19(26)11-22(17)27/h4-9,11,14-15,18H,2-3,10,12-13H2,1H3,(H,28,34) JYCUTZNIOGCBCR-UHFFFAOYSA-N 694478 US20240293412, Compound TABLE2.31 Nicotinamide phosphoribosyltransferase Homo sapiens 23400 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694478&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570618 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(F)cc1Cl InChI=1S/C25H24ClFN6O/c1-16-4-8-20(9-5-16)33-14-21-23(31-33)29-15-30-24(21)32-10-2-3-18(13-32)25(34)28-12-17-6-7-19(27)11-22(17)26/h4-9,11,14-15,18H,2-3,10,12-13H2,1H3,(H,28,34) SJRIXDNZNCKODI-UHFFFAOYSA-N 694479 US20240293412, Compound TABLE2.32 Nicotinamide phosphoribosyltransferase Homo sapiens 13500 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694479&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570619 Fc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(Cl)cc1 InChI=1S/C24H22ClFN6O/c25-18-5-3-16(4-6-18)12-27-24(33)17-2-1-11-31(13-17)23-21-14-32(30-22(21)28-15-29-23)20-9-7-19(26)8-10-20/h3-10,14-15,17H,1-2,11-13H2,(H,27,33) FFWRMNXQOMQMPD-UHFFFAOYSA-N 50631637 CHEMBL5393934 Nicotinamide phosphoribosyltransferase Homo sapiens 2630 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631637 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631637&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 53039108 505035971 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570620 CCc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C26H27FN6O/c1-2-18-5-7-19(8-6-18)14-28-26(34)20-4-3-13-32(15-20)25-23-16-33(31-24(23)29-17-30-25)22-11-9-21(27)10-12-22/h5-12,16-17,20H,2-4,13-15H2,1H3,(H,28,34) IQLCXAMVKZMLSL-UHFFFAOYSA-N 50631638 CHEMBL5396283 Nicotinamide phosphoribosyltransferase Homo sapiens 4690 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631638 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631638&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 53039110 505035972 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570621 CSc1ccc(CNC(=O)[C@@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C26H28N6OS/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(34-2)12-8-19/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33)/t20-/m1/s1 VWUOWUZLQDJSCV-HXUWFJFHSA-N 694467 US20240293412, Compound TABLE2.20 Nicotinamide phosphoribosyltransferase Homo sapiens 265 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694467&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search TIE 8DSC 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570622 CSc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C26H28N6OS/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(34-2)12-8-19/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33)/t20-/m0/s1 VWUOWUZLQDJSCV-FQEVSTJZSA-N 694468 US20240293412, Compound TABLE2.21 Nicotinamide phosphoribosyltransferase Homo sapiens 1460 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694468&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search TIW 8DSD 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570623 COC(=O)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(SC)cc1 InChI=1S/C27H28N6O3S/c1-36-27(35)19-7-9-21(10-8-19)33-16-23-24(31-33)29-17-30-25(23)32-13-3-4-20(15-32)26(34)28-14-18-5-11-22(37-2)12-6-18/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,28,34) SSQCTASAALQWNS-UHFFFAOYSA-N 694448 US20240293412, Compound TABLE2.1 Nicotinamide phosphoribosyltransferase Homo sapiens 160 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694448&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570624 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C26H27FN6OS/c1-17-5-8-20(12-23(17)27)33-15-22-24(31-33)29-16-30-25(22)32-11-3-4-19(14-32)26(34)28-13-18-6-9-21(35-2)10-7-18/h5-10,12,15-16,19H,3-4,11,13-14H2,1-2H3,(H,28,34) BVMLQGGCAZPZLK-UHFFFAOYSA-N 694451 US20240293412, Compound TABLE2.4 Nicotinamide phosphoribosyltransferase Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694451&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570625 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2cccc(C)c2)cc1 InChI=1S/C26H28N6OS/c1-18-5-3-7-21(13-18)32-16-23-24(30-32)28-17-29-25(23)31-12-4-6-20(15-31)26(33)27-14-19-8-10-22(34-2)11-9-19/h3,5,7-11,13,16-17,20H,4,6,12,14-15H2,1-2H3,(H,27,33) MOFLQXAGMRXGFI-UHFFFAOYSA-N 694455 US20240293412, Compound TABLE2.8 Nicotinamide phosphoribosyltransferase Homo sapiens 789 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694455&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570626 CSc1ccc(cc1)[C@H](C)NC(=O)[C@@H]1CCCN(C1)c1ncnc2nn(cc12)-c1ccc(C)cc1 InChI=1S/C27H30N6OS/c1-18-6-10-22(11-7-18)33-16-24-25(31-33)28-17-29-26(24)32-14-4-5-21(15-32)27(34)30-19(2)20-8-12-23(35-3)13-9-20/h6-13,16-17,19,21H,4-5,14-15H2,1-3H3,(H,30,34)/t19-,21+/m0/s1 TVSWAZJEAZRITM-PZJWPPBQSA-N 694456 US20240293412, Compound TABLE2.9 Nicotinamide phosphoribosyltransferase Homo sapiens 819 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694456&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570627 CSc1ccc(cc1)[C@H](C)NC(=O)[C@H]1CCCN(C1)c1ncnc2nn(cc12)-c1ccc(C)cc1 InChI=1S/C27H30N6OS/c1-18-6-10-22(11-7-18)33-16-24-25(31-33)28-17-29-26(24)32-14-4-5-21(15-32)27(34)30-19(2)20-8-12-23(35-3)13-9-20/h6-13,16-17,19,21H,4-5,14-15H2,1-3H3,(H,30,34)/t19-,21-/m0/s1 TVSWAZJEAZRITM-FPOVZHCZSA-N 694458 US20240293412, Compound TABLE2.11 Nicotinamide phosphoribosyltransferase Homo sapiens 1950 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694458&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570628 CSc1ccc(cc1)[C@@H](C)NC(=O)[C@@H]1CCCN(C1)c1ncnc2nn(cc12)-c1ccc(C)cc1 InChI=1S/C27H30N6OS/c1-18-6-10-22(11-7-18)33-16-24-25(31-33)28-17-29-26(24)32-14-4-5-21(15-32)27(34)30-19(2)20-8-12-23(35-3)13-9-20/h6-13,16-17,19,21H,4-5,14-15H2,1-3H3,(H,30,34)/t19-,21-/m1/s1 TVSWAZJEAZRITM-TZIWHRDSSA-N 694457 US20240293412, Compound TABLE2.10 Nicotinamide phosphoribosyltransferase Homo sapiens 1400 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694457&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570629 CSc1ccc(cc1)[C@@H](C)NC(=O)[C@H]1CCCN(C1)c1ncnc2nn(cc12)-c1ccc(C)cc1 InChI=1S/C27H30N6OS/c1-18-6-10-22(11-7-18)33-16-24-25(31-33)28-17-29-26(24)32-14-4-5-21(15-32)27(34)30-19(2)20-8-12-23(35-3)13-9-20/h6-13,16-17,19,21H,4-5,14-15H2,1-3H3,(H,30,34)/t19-,21+/m1/s1 TVSWAZJEAZRITM-CTNGQTDRSA-N 694459 US20240293412, Compound TABLE2.12 Nicotinamide phosphoribosyltransferase Homo sapiens 3210 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694459&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570630 CSc1ccc(CNC(=O)[C@@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C26H27FN6OS/c1-17-5-8-20(12-23(17)27)33-15-22-24(31-33)29-16-30-25(22)32-11-3-4-19(14-32)26(34)28-13-18-6-9-21(35-2)10-7-18/h5-10,12,15-16,19H,3-4,11,13-14H2,1-2H3,(H,28,34)/t19-/m1/s1 BVMLQGGCAZPZLK-LJQANCHMSA-N 694452 US20240293412, Compound TABLE2.5 Nicotinamide phosphoribosyltransferase Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694452&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570631 CSc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C26H27FN6OS/c1-17-5-8-20(12-23(17)27)33-15-22-24(31-33)29-16-30-25(22)32-11-3-4-19(14-32)26(34)28-13-18-6-9-21(35-2)10-7-18/h5-10,12,15-16,19H,3-4,11,13-14H2,1-2H3,(H,28,34)/t19-/m0/s1 BVMLQGGCAZPZLK-IBGZPJMESA-N 694453 US20240293412, Compound TABLE2.6 Nicotinamide phosphoribosyltransferase Homo sapiens 54 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694453&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570632 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(O)cc2)cc1 InChI=1S/C25H26N6O2S/c1-34-21-10-4-17(5-11-21)13-26-25(33)18-3-2-12-30(14-18)24-22-15-31(29-23(22)27-16-28-24)19-6-8-20(32)9-7-19/h4-11,15-16,18,32H,2-3,12-14H2,1H3,(H,26,33) JIWYEFXZMBCIIH-UHFFFAOYSA-N 694462 US20240293412, Compound TABLE2.15 Nicotinamide phosphoribosyltransferase Homo sapiens 2320 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694462&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570633 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccccc2)cc1 InChI=1S/C25H26N6OS/c1-33-21-11-9-18(10-12-21)14-26-25(32)19-6-5-13-30(15-19)24-22-16-31(20-7-3-2-4-8-20)29-23(22)27-17-28-24/h2-4,7-12,16-17,19H,5-6,13-15H2,1H3,(H,26,32) YBGJWKYWOKTFNI-UHFFFAOYSA-N 694463 US20240293412, Compound TABLE2.16 Nicotinamide phosphoribosyltransferase Homo sapiens 749 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694463&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570634 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(Br)cc2)cc1 InChI=1S/C25H25BrN6OS/c1-34-21-10-4-17(5-11-21)13-27-25(33)18-3-2-12-31(14-18)24-22-15-32(30-23(22)28-16-29-24)20-8-6-19(26)7-9-20/h4-11,15-16,18H,2-3,12-14H2,1H3,(H,27,33) KAPQCHJAWKAAKT-UHFFFAOYSA-N 694464 US20240293412, Compound TABLE2.17 Nicotinamide phosphoribosyltransferase Homo sapiens 24 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694464&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570635 CSc1ccc(CNC(=O)[C@@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C26H25F3N6OS/c1-37-21-10-4-17(5-11-21)13-30-25(36)18-3-2-12-34(14-18)24-22-15-35(33-23(22)31-16-32-24)20-8-6-19(7-9-20)26(27,28)29/h4-11,15-16,18H,2-3,12-14H2,1H3,(H,30,36)/t18-/m1/s1 DBSWYQCSXRNOMX-GOSISDBHSA-N 50631639 CHEMBL5433160 Nicotinamide phosphoribosyltransferase Homo sapiens 36 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631639 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631639&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406729 505035973 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570636 CSc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(cc2)C(F)(F)F)cc1 InChI=1S/C26H25F3N6OS/c1-37-21-10-4-17(5-11-21)13-30-25(36)18-3-2-12-34(14-18)24-22-15-35(33-23(22)31-16-32-24)20-8-6-19(7-9-20)26(27,28)29/h4-11,15-16,18H,2-3,12-14H2,1H3,(H,30,36)/t18-/m0/s1 DBSWYQCSXRNOMX-SFHVURJKSA-N 50631640 CHEMBL5396979 Nicotinamide phosphoribosyltransferase Homo sapiens 724 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631640 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631640&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406489 505035974 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570637 CSc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(F)cc2)cc1 InChI=1S/C25H25FN6OS/c1-34-21-10-4-17(5-11-21)13-27-25(33)18-3-2-12-31(14-18)24-22-15-32(30-23(22)28-16-29-24)20-8-6-19(26)7-9-20/h4-11,15-16,18H,2-3,12-14H2,1H3,(H,27,33) DTUSZHLRRMMBOD-UHFFFAOYSA-N 50631641 CHEMBL5413979 Nicotinamide phosphoribosyltransferase Homo sapiens 2770 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631641 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631641&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406790 505035975 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570638 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@H](C1)C(=O)NCc1ccc(Br)cc1 InChI=1S/C25H25BrN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33)/t19-/m1/s1 GEMKHIOGDNIYKW-LJQANCHMSA-N 694449 US20240293412, Compound TABLE2.2 Nicotinamide phosphoribosyltransferase Homo sapiens 612 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694449&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570639 Brc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(Br)cc2)cc1 InChI=1S/C24H22Br2N6O/c25-18-5-3-16(4-6-18)12-27-24(33)17-2-1-11-31(13-17)23-21-14-32(30-22(21)28-15-29-23)20-9-7-19(26)8-10-20/h3-10,14-15,17H,1-2,11-13H2,(H,27,33) ZOYOSXSKEOBXQK-UHFFFAOYSA-N 694465 US20240293412, Compound TABLE2.18 Nicotinamide phosphoribosyltransferase Homo sapiens 101 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694465&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570640 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc(Br)cc1 InChI=1S/C25H25BrN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33)/t19-/m0/s1 GEMKHIOGDNIYKW-IBGZPJMESA-N 694450 US20240293412, Compound TABLE2.3 Nicotinamide phosphoribosyltransferase Homo sapiens 11900 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694450&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570641 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(Br)cc1 InChI=1S/C25H24BrFN6O/c1-16-4-9-20(11-22(16)27)33-14-21-23(31-33)29-15-30-24(21)32-10-2-3-18(13-32)25(34)28-12-17-5-7-19(26)8-6-17/h4-9,11,14-15,18H,2-3,10,12-13H2,1H3,(H,28,34) IZUVOQRKOHMQEY-UHFFFAOYSA-N 694454 US20240293412, Compound TABLE2.7 Nicotinamide phosphoribosyltransferase Homo sapiens 58 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694454&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570642 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(Br)cc1 InChI=1S/C25H25BrN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33) GEMKHIOGDNIYKW-UHFFFAOYSA-N 50631642 CHEMBL5427182 Nicotinamide phosphoribosyltransferase Homo sapiens 636 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631642 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631642&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406784 505035976 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570643 COc1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C26H28N6O2/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(34-2)12-8-19/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33) GXMOJHFTBNRRGM-UHFFFAOYSA-N 50631645 CHEMBL5399360 Nicotinamide phosphoribosyltransferase Homo sapiens 2390 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631645&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 50819661 505035979 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570644 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1ccc(I)cc1 InChI=1S/C25H25IN6O/c1-17-4-10-21(11-5-17)32-15-22-23(30-32)28-16-29-24(22)31-12-2-3-19(14-31)25(33)27-13-18-6-8-20(26)9-7-18/h4-11,15-16,19H,2-3,12-14H2,1H3,(H,27,33) SBTXPPRAOJSXSO-UHFFFAOYSA-N 694470 US20240293412, Compound TABLE2.23 Nicotinamide phosphoribosyltransferase Homo sapiens 992 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694470&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570645 CC(=O)c1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C27H28N6O2/c1-18-5-11-23(12-6-18)33-16-24-25(31-33)29-17-30-26(24)32-13-3-4-22(15-32)27(35)28-14-20-7-9-21(10-8-20)19(2)34/h5-12,16-17,22H,3-4,13-15H2,1-2H3,(H,28,35) GMHQCMJIOKCBAZ-UHFFFAOYSA-N 694473 US20240293412, Compound TABLE2.26 Nicotinamide phosphoribosyltransferase Homo sapiens 4116 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694473&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570646 C[S+]([O-])c1ccc(CNC(=O)C2CCCN(C2)c2ncnc3nn(cc23)-c2ccc(C)cc2)cc1 InChI=1S/C26H28N6O2S/c1-18-5-9-21(10-6-18)32-16-23-24(30-32)28-17-29-25(23)31-13-3-4-20(15-31)26(33)27-14-19-7-11-22(12-8-19)35(2)34/h5-12,16-17,20H,3-4,13-15H2,1-2H3,(H,27,33) IAIPPANZBRWUJT-UHFFFAOYSA-N 50631646 CHEMBL5414936 Nicotinamide phosphoribosyltransferase Homo sapiens 12000 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631646 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631646&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406832 505035980 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570647 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C27H25FN6OS/c1-17-4-6-21(12-23(17)28)34-15-22-25(32-34)30-16-31-26(22)33-9-2-3-20(14-33)27(35)29-13-18-5-7-24-19(11-18)8-10-36-24/h4-8,10-12,15-16,20H,2-3,9,13-14H2,1H3,(H,29,35)/t20-/m1/s1 LQSRIPAMJVTBAV-HXUWFJFHSA-N 694460 US20240293412, Compound TABLE2.13 Nicotinamide phosphoribosyltransferase Homo sapiens 14 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694460&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570648 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C27H25FN6OS/c1-17-4-6-21(12-23(17)28)34-15-22-25(32-34)30-16-31-26(22)33-9-2-3-20(14-33)27(35)29-13-18-5-7-24-19(11-18)8-10-36-24/h4-8,10-12,15-16,20H,2-3,9,13-14H2,1H3,(H,29,35)/t20-/m0/s1 LQSRIPAMJVTBAV-FQEVSTJZSA-N 694461 US20240293412, Compound TABLE2.14 Nicotinamide phosphoribosyltransferase Homo sapiens 44 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694461&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search XI3 8F7L 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570649 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C27H23F3N6OS/c28-27(29,30)20-4-6-21(7-5-20)36-15-22-24(34-36)32-16-33-25(22)35-10-1-2-19(14-35)26(37)31-13-17-3-8-23-18(12-17)9-11-38-23/h3-9,11-12,15-16,19H,1-2,10,13-14H2,(H,31,37)/t19-/m1/s1 RPVUYLFRBVBINJ-LJQANCHMSA-N 50631649 CHEMBL5431721 Nicotinamide phosphoribosyltransferase Homo sapiens 22 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631649 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631649&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406582 505035983 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570650 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C27H23F3N6OS/c28-27(29,30)20-4-6-21(7-5-20)36-15-22-24(34-36)32-16-33-25(22)35-10-1-2-19(14-35)26(37)31-13-17-3-8-23-18(12-17)9-11-38-23/h3-9,11-12,15-16,19H,1-2,10,13-14H2,(H,31,37)/t19-/m0/s1 RPVUYLFRBVBINJ-IBGZPJMESA-N 50631650 CHEMBL5396153 Nicotinamide phosphoribosyltransferase Homo sapiens 477 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631650 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631650&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search TKF 8DTJ 165406683 505035984 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570651 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2[nH]ccc2c1 InChI=1S/C27H26FN7O/c1-17-4-6-21(12-23(17)28)35-15-22-25(33-35)31-16-32-26(22)34-10-2-3-20(14-34)27(36)30-13-18-5-7-24-19(11-18)8-9-29-24/h4-9,11-12,15-16,20,29H,2-3,10,13-14H2,1H3,(H,30,36)/t20-/m0/s1 XXKUVEJIXZKSAQ-FQEVSTJZSA-N 50631653 CHEMBL5403615 Nicotinamide phosphoribosyltransferase Homo sapiens 3380 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631653 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631653&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406748 505035987 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570652 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC[C@@H](C1)C(=O)NCc1ccc2ncccc2c1 InChI=1S/C28H26FN7O/c1-18-6-8-22(13-24(18)29)36-16-23-26(34-36)32-17-33-27(23)35-11-3-5-21(15-35)28(37)31-14-19-7-9-25-20(12-19)4-2-10-30-25/h2,4,6-10,12-13,16-17,21H,3,5,11,14-15H2,1H3,(H,31,37)/t21-/m0/s1 BSVHAHLLYZTCMX-NRFANRHFSA-N 50631654 CHEMBL5438473 Nicotinamide phosphoribosyltransferase Homo sapiens 2560 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631654 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631654&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 172470018 505035988 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570653 Cc1ccc(cc1)-n1cc2c(ncnc2n1)N1CCCC(C1)C(=O)NCc1cccnc1 InChI=1S/C24H25N7O/c1-17-6-8-20(9-7-17)31-15-21-22(29-31)27-16-28-23(21)30-11-3-5-19(14-30)24(32)26-13-18-4-2-10-25-12-18/h2,4,6-10,12,15-16,19H,3,5,11,13-14H2,1H3,(H,26,32) OJMPHPDVYHBNJG-UHFFFAOYSA-N 50631660 CHEMBL5396898 Nicotinamide phosphoribosyltransferase Homo sapiens 8660 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631660 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631660&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 172440385 505035994 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570654 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCC(C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C26H23FN6OS/c1-16-2-4-20(11-22(16)27)33-14-21-24(31-33)29-15-30-25(21)32-8-6-19(13-32)26(34)28-12-17-3-5-23-18(10-17)7-9-35-23/h2-5,7,9-11,14-15,19H,6,8,12-13H2,1H3,(H,28,34) CBYHAEJFNJOBTL-UHFFFAOYSA-N 50631661 CHEMBL5405783 Nicotinamide phosphoribosyltransferase Homo sapiens 1010 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631661 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631661&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406820 505035995 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570655 CSc1ccc(CNC(=O)C2CCN(C2)c2ncnc3nn(cc23)-c2ccc(C)c(F)c2)cc1 InChI=1S/C25H25FN6OS/c1-16-3-6-19(11-22(16)26)32-14-21-23(30-32)28-15-29-24(21)31-10-9-18(13-31)25(33)27-12-17-4-7-20(34-2)8-5-17/h3-8,11,14-15,18H,9-10,12-13H2,1-2H3,(H,27,33) GAAVPXCBTWQRMY-UHFFFAOYSA-N 50631663 CHEMBL5437419 Nicotinamide phosphoribosyltransferase Homo sapiens 1090 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 Shen, Z; Ratia, K; Krider, I; Ackerman-Berrier, M; Penton, C; Musku, SR; Gordon-Blake, JM; Laham, MS; Christie, N; Ma, N; Fu, J; Xiong, R; Courey, JM; Velma, GR; Thatcher, GRJ 12/28/2023 12/21/2024 University of Arizona http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50631663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50631663&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 165406583 505035997 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570656 CN1CCN(C[C@H]1C(=O)NCc1ccc2sccc2c1)c1ncnc2nn(cc12)-c1ccc(cc1)C(F)(F)F InChI=1S/C27H24F3N7OS/c1-35-9-10-36(15-22(35)26(38)31-13-17-2-7-23-18(12-17)8-11-39-23)25-21-14-37(34-24(21)32-16-33-25)20-5-3-19(4-6-20)27(28,29)30/h2-8,11-12,14,16,22H,9-10,13,15H2,1H3,(H,31,38)/t22-/m0/s1 ZXBNPADWSUISJZ-QFIPXVFZSA-N 694485 US20240293412, Compound TABLE2.38 Nicotinamide phosphoribosyltransferase Homo sapiens 162 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694485&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570657 CN1CCN(C[C@H]1C(=O)NCc1ccc2sccc2c1)c1ncnc2nn(cc12)-c1ccc(C)c(F)c1 InChI=1S/C27H26FN7OS/c1-17-3-5-20(12-22(17)28)35-14-21-25(32-35)30-16-31-26(21)34-9-8-33(2)23(15-34)27(36)29-13-18-4-6-24-19(11-18)7-10-37-24/h3-7,10-12,14,16,23H,8-9,13,15H2,1-2H3,(H,29,36)/t23-/m0/s1 XQQWDPYKSGUYNU-QHCPKHFHSA-N 694483 US20240293412, Compound TABLE2.36 Nicotinamide phosphoribosyltransferase Homo sapiens 90 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694483&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570658 Cc1ccc(cc1F)-n1cc2c(ncnc2n1)N1CCN[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C26H24FN7OS/c1-16-2-4-19(11-21(16)27)34-13-20-24(32-34)30-15-31-25(20)33-8-7-28-22(14-33)26(35)29-12-17-3-5-23-18(10-17)6-9-36-23/h2-6,9-11,13,15,22,28H,7-8,12,14H2,1H3,(H,29,35)/t22-/m0/s1 BPWFZVHRVMSJIY-QFIPXVFZSA-N 694482 US20240293412, Compound TABLE2.35 Nicotinamide phosphoribosyltransferase Homo sapiens 38 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694482&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570659 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCN[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C26H22F3N7OS/c27-26(28,29)18-2-4-19(5-3-18)36-13-20-23(34-36)32-15-33-24(20)35-9-8-30-21(14-35)25(37)31-12-16-1-6-22-17(11-16)7-10-38-22/h1-7,10-11,13,15,21,30H,8-9,12,14H2,(H,31,37)/t21-/m0/s1 PNEQDEPNUMZDMO-NRFANRHFSA-N 694484 US20240293412, Compound TABLE2.37 Nicotinamide phosphoribosyltransferase Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694484&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570660 O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1 InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+ KPBNHDGDUADAGP-VAWYXSNFSA-N 81395 APO-866 Nicotinamide phosphoribosyltransferase Homo sapiens 10.0 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81395 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81395&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search DGB 4O1D,4O1B,2GVJ,2G97 6914657 131341969 ZINC03828115 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95 51570661 FC(F)(F)c1ccc(cc1)-n1cc2c(ncnc2n1)N1CCN[C@@H](C1)C(=O)NCc1ccc2sccc2c1 InChI=1S/C26H22F3N7OS/c27-26(28,29)18-2-4-19(5-3-18)36-13-20-23(34-36)32-15-33-24(20)35-9-8-30-21(14-35)25(37)31-12-16-1-6-22-17(11-16)7-10-38-22/h1-7,10-11,13,15,21,30H,8-9,12,14H2,(H,31,37)/t21-/m0/s1 PNEQDEPNUMZDMO-NRFANRHFSA-N 694484 US20240293412, Compound TABLE2.37 Nicotinamide phosphoribosyltransferase Homo sapiens 85 ChEMBL 10.1021/acs.jmedchem.3c01406 10.7270/Q2P84HBS 38096366 n/a 12/28/2023 12/21/2024 n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=694484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4910&target=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=694484&enzyme=Nicotinamide+phosphoribosyltransferase&column=ki&startPg=0&Increment=50&submit=Search 1 MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH 7PPI,7PPH,7PPG,7PPF,7PPE,5LX5,5LX3,8IVU,5WI1,5WI0,5KIT,2GVJ,2GVG,5UPF,5UPE,5NSD,8TM7,8F7L,8DTJ,8DSM,8DSI,8DSH,8DSE,8DSD,8DSC,7ENQ,6TA2,6TA0,6B76,6B75,6ATB,4WQ6,4O13,4O12,4O10,4O0Z,4N9E,4N9D,4N9C,4N9B,4M6Q,4M6P,4LWW,4LVG,4LVF,4LVD,4LVB,4LVA,4LV9,4LTS,4L4M,4L4L,4KFP,4KFO,4KFN,4JR5,4JNM,2E5D,2E5C,2E5B,6PEB,3DKL,3DKJ,3DHF,3DHD,3DGR,6E68,6TAC,5U2N,5U2M Nicotinamide phosphoribosyltransferase NAMPT_HUMAN P43490 A4D0Q9 A4D0R0 Q3KQV0 Q8WW95