BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 51605563 N#CCCS(=O)(=O)C/C(=C\c1ccc(Cl)cc1)C(=O)NCCc1ccccc1 InChI=1S/C21H21ClN2O3S/c22-20-9-7-18(8-10-20)15-19(16-28(26,27)14-4-12-23)21(25)24-13-11-17-5-2-1-3-6-17/h1-3,5-10,15H,4,11,13-14,16H2,(H,24,25) CHNSUCRGLROQHW-UHFFFAOYSA-N 50647074 CHEMBL5593521 NACHT, LRR and PYD domains-containing protein 3 Human 4070 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647074&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378375 519662476 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605564 CNC(=O)/C(=C/c1ccc(Cl)cc1)CS(=O)(=O)CCC#N InChI=1S/C14H15ClN2O3S/c1-17-14(18)12(10-21(19,20)8-2-7-16)9-11-3-5-13(15)6-4-11/h3-6,9H,2,8,10H2,1H3,(H,17,18) HKNRAVAODZEKNN-UHFFFAOYSA-N 50647075 CHEMBL5592662 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647075 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647075&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378376 519662477 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605565 CN(C)C(=O)/C(=C/c1ccc(Cl)cc1)CS(=O)(=O)CCC#N InChI=1S/C15H17ClN2O3S/c1-18(2)15(19)13(11-22(20,21)9-3-8-17)10-12-4-6-14(16)7-5-12/h4-7,10H,3,9,11H2,1-2H3 UMHXZYCBKDUMSO-UHFFFAOYSA-N 50647076 CHEMBL5595419 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647076&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378377 519662478 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605566 CCCNC(=O)/C(=C/c1ccc(Cl)cc1)CS(=O)(=O)CCC#N InChI=1S/C16H19ClN2O3S/c1-2-9-19-16(20)14(12-23(21,22)10-3-8-18)11-13-4-6-15(17)7-5-13/h4-7,11H,2-3,9-10,12H2,1H3,(H,19,20) KFYNABRYCOYQCP-UHFFFAOYSA-N 50647077 CHEMBL5592212 NACHT, LRR and PYD domains-containing protein 3 Human 6930 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647077 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647077&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378378 519662479 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605567 N#CCCS(=O)(=O)C/C(=C\c1ccc(Cl)cc1)C(=O)NC1CC1 InChI=1S/C16H17ClN2O3S/c17-14-4-2-12(3-5-14)10-13(16(20)19-15-6-7-15)11-23(21,22)9-1-8-18/h2-5,10,15H,1,6-7,9,11H2,(H,19,20) SEDIUFQWBGVUOX-UHFFFAOYSA-N 50647078 CHEMBL5595491 NACHT, LRR and PYD domains-containing protein 3 Human 7310 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647078 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647078&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378379 519662480 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605568 N#CCCS(=O)(=O)C/C(=C\c1ccc(Cl)cc1)C(=O)NCC1CC1 InChI=1S/C17H19ClN2O3S/c18-16-6-4-13(5-7-16)10-15(12-24(22,23)9-1-8-19)17(21)20-11-14-2-3-14/h4-7,10,14H,1-3,9,11-12H2,(H,20,21) MQRRZCBXIVKDAL-UHFFFAOYSA-N 50647079 CHEMBL5593637 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647079 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647079&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378380 519662481 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605569 N#CCCS(=O)(=O)C/C(=C\c1ccc(Cl)cc1)C(=O)N1CC(O)C1 InChI=1S/C16H17ClN2O4S/c17-14-4-2-12(3-5-14)8-13(11-24(22,23)7-1-6-18)16(21)19-9-15(20)10-19/h2-5,8,15,20H,1,7,9-11H2 UXELPQLZOMVHGV-UHFFFAOYSA-N 50647080 CHEMBL5595666 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647080 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647080&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378381 519662482 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605570 N#CCCS(=O)(=O)C/C(=C\c1ccc(Cl)cc1)C(=O)N1CCCC1 InChI=1S/C17H19ClN2O3S/c18-16-6-4-14(5-7-16)12-15(13-24(22,23)11-3-8-19)17(21)20-9-1-2-10-20/h4-7,12H,1-3,9-11,13H2 ZFMTYZABKRCDEX-UHFFFAOYSA-N 50647081 CHEMBL5590194 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647081 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647081&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378382 519662483 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605571 N#CCCS(=O)(=O)C/C(=C\c1ccc(Cl)cc1)C(=O)NC1CCCC1 InChI=1S/C18H21ClN2O3S/c19-16-8-6-14(7-9-16)12-15(13-25(23,24)11-3-10-20)18(22)21-17-4-1-2-5-17/h6-9,12,17H,1-5,11,13H2,(H,21,22) XDCIYKHLKQLYBV-UHFFFAOYSA-N 50647082 CHEMBL5593101 NACHT, LRR and PYD domains-containing protein 3 Human 9740 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647082 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647082&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378383 519662484 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605572 N#CCCS(=O)(=O)C/C(=C\c1ccc(Cl)cc1)C(=O)N1CCOCC1 InChI=1S/C17H19ClN2O4S/c18-16-4-2-14(3-5-16)12-15(13-25(22,23)11-1-6-19)17(21)20-7-9-24-10-8-20/h2-5,12H,1,7-11,13H2 VXNDCRZSLRERDJ-UHFFFAOYSA-N 50647083 CHEMBL5594368 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647083 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647083&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378384 519662485 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605573 N#CCCS(=O)(=O)C/C(=C\c1ccc(Cl)cc1)C(=O)NCCc1ccc(S(N)(=O)=O)cc1 InChI=1S/C21H22ClN3O5S2/c22-19-6-2-17(3-7-19)14-18(15-31(27,28)13-1-11-23)21(26)25-12-10-16-4-8-20(9-5-16)32(24,29)30/h2-9,14H,1,10,12-13,15H2,(H,25,26)(H2,24,29,30) QXKICTGKAKSDMB-UHFFFAOYSA-N 50647084 CHEMBL5595175 NACHT, LRR and PYD domains-containing protein 3 Human 4420 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647084 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647084&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378385 519662486 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605574 CCCNC(=O)/C(=C/c1ccc(Br)cc1)CS(=O)(=O)CCC#N InChI=1S/C16H19BrN2O3S/c1-2-9-19-16(20)14(12-23(21,22)10-3-8-18)11-13-4-6-15(17)7-5-13/h4-7,11H,2-3,9-10,12H2,1H3,(H,19,20) WAADGPMOPCYMRF-UHFFFAOYSA-N 50647085 CHEMBL5592767 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647085 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647085&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378386 519662487 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605575 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NC1CC1 InChI=1S/C16H17BrN2O3S/c17-14-4-2-12(3-5-14)10-13(16(20)19-15-6-7-15)11-23(21,22)9-1-8-18/h2-5,10,15H,1,6-7,9,11H2,(H,19,20) UXHXGZWSKWZRTB-UHFFFAOYSA-N 50647086 CHEMBL5595876 NACHT, LRR and PYD domains-containing protein 3 Human 4310 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647086&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378387 519662488 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605576 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NC1CCCC1 InChI=1S/C18H21BrN2O3S/c19-16-8-6-14(7-9-16)12-15(13-25(23,24)11-3-10-20)18(22)21-17-4-1-2-5-17/h6-9,12,17H,1-5,11,13H2,(H,21,22) XQLKNUIRNZTAJD-UHFFFAOYSA-N 50647087 CHEMBL5593090 NACHT, LRR and PYD domains-containing protein 3 Human 7670 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647087&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378388 519662489 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605577 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1ccccc1 InChI=1S/C21H21BrN2O3S/c22-20-9-7-18(8-10-20)15-19(16-28(26,27)14-4-12-23)21(25)24-13-11-17-5-2-1-3-6-17/h1-3,5-10,15H,4,11,13-14,16H2,(H,24,25) IOWJGAUCZDGHSV-UHFFFAOYSA-N 50647088 CHEMBL5596006 NACHT, LRR and PYD domains-containing protein 3 Human 1070 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647088 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647088&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378389 519662490 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605578 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1ccc(S(N)(=O)=O)cc1 InChI=1S/C21H22BrN3O5S2/c22-19-6-2-17(3-7-19)14-18(15-31(27,28)13-1-11-23)21(26)25-12-10-16-4-8-20(9-5-16)32(24,29)30/h2-9,14H,1,10,12-13,15H2,(H,25,26)(H2,24,29,30) PCRKJFKFSINGCC-UHFFFAOYSA-N 50647089 CHEMBL5594957 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647089 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647089&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378390 519662491 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605579 CCCNC(=O)/C(=C/c1cccc(Cl)c1)CS(=O)(=O)CCC#N InChI=1S/C16H19ClN2O3S/c1-2-8-19-16(20)14(12-23(21,22)9-4-7-18)10-13-5-3-6-15(17)11-13/h3,5-6,10-11H,2,4,8-9,12H2,1H3,(H,19,20) VKBSUXNQHAXLLW-UHFFFAOYSA-N 50647090 CHEMBL5592777 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647090&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378391 519662492 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605580 N#CCCS(=O)(=O)C/C(=C\c1cccc(Cl)c1)C(=O)NC1CC1 InChI=1S/C16H17ClN2O3S/c17-14-4-1-3-12(10-14)9-13(16(20)19-15-5-6-15)11-23(21,22)8-2-7-18/h1,3-4,9-10,15H,2,5-6,8,11H2,(H,19,20) KKPQOLONLFTQTI-UHFFFAOYSA-N 50647091 CHEMBL5593950 NACHT, LRR and PYD domains-containing protein 3 Human 9890 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647091 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647091&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378392 519662493 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605581 N#CCCS(=O)(=O)C/C(=C\c1cccc(Cl)c1)C(=O)NC1CCCC1 InChI=1S/C18H21ClN2O3S/c19-16-6-3-5-14(12-16)11-15(13-25(23,24)10-4-9-20)18(22)21-17-7-1-2-8-17/h3,5-6,11-12,17H,1-2,4,7-8,10,13H2,(H,21,22) LTXPNHQQRAQZIF-UHFFFAOYSA-N 50647092 CHEMBL5583735 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647092 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647092&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378393 519662494 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605582 N#CCCS(=O)(=O)C/C(=C\c1cccc(Cl)c1)C(=O)NCCc1ccccc1 InChI=1S/C21H21ClN2O3S/c22-20-9-4-8-18(15-20)14-19(16-28(26,27)13-5-11-23)21(25)24-12-10-17-6-2-1-3-7-17/h1-4,6-9,14-15H,5,10,12-13,16H2,(H,24,25) UMCQJTYSBAIMFW-UHFFFAOYSA-N 50647093 CHEMBL5594085 NACHT, LRR and PYD domains-containing protein 3 Human 7880 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647093&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378394 519662495 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605583 N#CCCS(=O)(=O)C/C(=C\c1cccc(Cl)c1)C(=O)NCCc1ccc(S(N)(=O)=O)cc1 InChI=1S/C21H22ClN3O5S2/c22-19-4-1-3-17(14-19)13-18(15-31(27,28)12-2-10-23)21(26)25-11-9-16-5-7-20(8-6-16)32(24,29)30/h1,3-8,13-14H,2,9,11-12,15H2,(H,25,26)(H2,24,29,30) GKCXCNDNKCVLQP-UHFFFAOYSA-N 50647094 CHEMBL5589977 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647094 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647094&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378395 519662496 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605584 CCCNC(=O)/C(=C/c1cccc(Br)c1)CS(=O)(=O)CCC#N InChI=1S/C16H19BrN2O3S/c1-2-8-19-16(20)14(12-23(21,22)9-4-7-18)10-13-5-3-6-15(17)11-13/h3,5-6,10-11H,2,4,8-9,12H2,1H3,(H,19,20) AETFVFVYNJQRRP-UHFFFAOYSA-N 50647095 CHEMBL5593730 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647095&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378396 519662497 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605585 N#CCCS(=O)(=O)C/C(=C\c1cccc(Br)c1)C(=O)NC1CC1 InChI=1S/C16H17BrN2O3S/c17-14-4-1-3-12(10-14)9-13(16(20)19-15-5-6-15)11-23(21,22)8-2-7-18/h1,3-4,9-10,15H,2,5-6,8,11H2,(H,19,20) FDMHQJQVUVVXOR-UHFFFAOYSA-N 50647096 CHEMBL5594303 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647096&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378397 519662498 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605586 N#CCCS(=O)(=O)C/C(=C\c1cccc(Br)c1)C(=O)NC1CCCC1 InChI=1S/C18H21BrN2O3S/c19-16-6-3-5-14(12-16)11-15(13-25(23,24)10-4-9-20)18(22)21-17-7-1-2-8-17/h3,5-6,11-12,17H,1-2,4,7-8,10,13H2,(H,21,22) KOKDEKYQSVGWDL-UHFFFAOYSA-N 50647097 CHEMBL5591887 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647097&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378398 519662499 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605587 N#CCCS(=O)(=O)C/C(=C\c1cccc(Br)c1)C(=O)NCCc1ccccc1 InChI=1S/C21H21BrN2O3S/c22-20-9-4-8-18(15-20)14-19(16-28(26,27)13-5-11-23)21(25)24-12-10-17-6-2-1-3-7-17/h1-4,6-9,14-15H,5,10,12-13,16H2,(H,24,25) NJUFLVUXVBJOFP-UHFFFAOYSA-N 50647098 CHEMBL5591774 NACHT, LRR and PYD domains-containing protein 3 Human 5190 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647098&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378399 519662500 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605588 N#CCCS(=O)(=O)C/C(=C\c1cccc(Br)c1)C(=O)NCCc1ccc(S(N)(=O)=O)cc1 InChI=1S/C21H22BrN3O5S2/c22-19-4-1-3-17(14-19)13-18(15-31(27,28)12-2-10-23)21(26)25-11-9-16-5-7-20(8-6-16)32(24,29)30/h1,3-8,13-14H,2,9,11-12,15H2,(H,25,26)(H2,24,29,30) VUBBWSYYEBRNGL-UHFFFAOYSA-N 50647099 CHEMBL5593527 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647099&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378400 519662501 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605589 CCCNC(=O)/C(=C/c1ccc2ccccc2c1)CS(=O)(=O)CCC#N InChI=1S/C20H22N2O3S/c1-2-11-22-20(23)19(15-26(24,25)12-5-10-21)14-16-8-9-17-6-3-4-7-18(17)13-16/h3-4,6-9,13-14H,2,5,11-12,15H2,1H3,(H,22,23) CVIWATKVHCCSMR-UHFFFAOYSA-N 50647100 CHEMBL5592332 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647100&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378401 519662502 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605590 N#CCCS(=O)(=O)C/C(=C\c1ccc2ccccc2c1)C(=O)NC1CC1 InChI=1S/C20H20N2O3S/c21-10-3-11-26(24,25)14-18(20(23)22-19-8-9-19)13-15-6-7-16-4-1-2-5-17(16)12-15/h1-2,4-7,12-13,19H,3,8-9,11,14H2,(H,22,23) AMQJQQBFEKWEJK-UHFFFAOYSA-N 50647101 CHEMBL5591402 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647101&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378402 519662503 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605591 N#CCCS(=O)(=O)C/C(=C\c1ccc2ccccc2c1)C(=O)NC1CCCC1 InChI=1S/C22H24N2O3S/c23-12-5-13-28(26,27)16-20(22(25)24-21-8-3-4-9-21)15-17-10-11-18-6-1-2-7-19(18)14-17/h1-2,6-7,10-11,14-15,21H,3-5,8-9,13,16H2,(H,24,25) PWIUDUSQULHFMM-UHFFFAOYSA-N 50647102 CHEMBL5592552 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647102&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378403 519662504 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605592 N#CCCS(=O)(=O)C/C(=C\c1ccc2ccccc2c1)C(=O)NCCc1ccccc1 InChI=1S/C25H24N2O3S/c26-14-6-16-31(29,30)19-24(25(28)27-15-13-20-7-2-1-3-8-20)18-21-11-12-22-9-4-5-10-23(22)17-21/h1-5,7-12,17-18H,6,13,15-16,19H2,(H,27,28) IIEAFSMSVGAXJD-UHFFFAOYSA-N 50647103 CHEMBL5590482 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647103&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378404 519662505 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605593 N#CCCS(=O)(=O)C/C(=C\c1ccc2ccccc2c1)C(=O)NCCc1ccc(S(N)(=O)=O)cc1 InChI=1S/C25H25N3O5S2/c26-13-3-15-34(30,31)18-23(17-20-6-9-21-4-1-2-5-22(21)16-20)25(29)28-14-12-19-7-10-24(11-8-19)35(27,32)33/h1-2,4-11,16-17H,3,12,14-15,18H2,(H,28,29)(H2,27,32,33) XHSODISIBFAROO-UHFFFAOYSA-N 50647104 CHEMBL5592831 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647104&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378405 519662506 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605594 CCCNC(=O)/C(=C/c1cc2ccccc2s1)CS(=O)(=O)CCC#N InChI=1S/C18H20N2O3S2/c1-2-9-20-18(21)15(13-25(22,23)10-5-8-19)12-16-11-14-6-3-4-7-17(14)24-16/h3-4,6-7,11-12H,2,5,9-10,13H2,1H3,(H,20,21) SZCVFQRGJALYLZ-UHFFFAOYSA-N 50647105 CHEMBL5593105 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647105&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378406 519662507 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605595 N#CCCS(=O)(=O)C/C(=C\c1cc2ccccc2s1)C(=O)NC1CC1 InChI=1S/C18H18N2O3S2/c19-8-3-9-25(22,23)12-14(18(21)20-15-6-7-15)11-16-10-13-4-1-2-5-17(13)24-16/h1-2,4-5,10-11,15H,3,6-7,9,12H2,(H,20,21) JUDPYZUKDNJMLC-UHFFFAOYSA-N 50647106 CHEMBL5590752 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647106&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378407 519662508 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605596 N#CCCS(=O)(=O)C/C(=C\c1cc2ccccc2s1)C(=O)NC1CCCC1 InChI=1S/C20H22N2O3S2/c21-10-5-11-27(24,25)14-16(20(23)22-17-7-2-3-8-17)13-18-12-15-6-1-4-9-19(15)26-18/h1,4,6,9,12-13,17H,2-3,5,7-8,11,14H2,(H,22,23) DPARNKJZCMQTMU-UHFFFAOYSA-N 50647107 CHEMBL5592142 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647107&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378408 519662509 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605597 N#CCCS(=O)(=O)C/C(=C\c1cc2ccccc2s1)C(=O)NCCc1ccccc1 InChI=1S/C23H22N2O3S2/c24-12-6-14-30(27,28)17-20(16-21-15-19-9-4-5-10-22(19)29-21)23(26)25-13-11-18-7-2-1-3-8-18/h1-5,7-10,15-16H,6,11,13-14,17H2,(H,25,26) NRCMJHXCOWXPGH-UHFFFAOYSA-N 50647108 CHEMBL5589633 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647108&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378409 519662510 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605598 CCCNC(=O)/C(=C/c1cc2ccccc2o1)CS(=O)(=O)CCC#N InChI=1S/C18H20N2O4S/c1-2-9-20-18(21)15(13-25(22,23)10-5-8-19)12-16-11-14-6-3-4-7-17(14)24-16/h3-4,6-7,11-12H,2,5,9-10,13H2,1H3,(H,20,21) AFYXEXODGJDNET-UHFFFAOYSA-N 50647109 CHEMBL5593889 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647109 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647109&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378410 519662511 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605599 N#CCCS(=O)(=O)C/C(=C\c1cc2ccccc2o1)C(=O)NC1CC1 InChI=1S/C18H18N2O4S/c19-8-3-9-25(22,23)12-14(18(21)20-15-6-7-15)11-16-10-13-4-1-2-5-17(13)24-16/h1-2,4-5,10-11,15H,3,6-7,9,12H2,(H,20,21) JQJWLIWOKQELCS-UHFFFAOYSA-N 50647110 CHEMBL5594976 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647110&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378411 519662512 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605600 N#CCCS(=O)(=O)C/C(=C\c1cc2ccccc2o1)C(=O)NC1CCCC1 InChI=1S/C20H22N2O4S/c21-10-5-11-27(24,25)14-16(20(23)22-17-7-2-3-8-17)13-18-12-15-6-1-4-9-19(15)26-18/h1,4,6,9,12-13,17H,2-3,5,7-8,11,14H2,(H,22,23) SKDQUEYZGXGPTQ-UHFFFAOYSA-N 50647111 CHEMBL5593191 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647111&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378412 519662513 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605601 N#CCCS(=O)(=O)C/C(=C\c1cc2ccccc2o1)C(=O)NCCc1ccccc1 InChI=1S/C23H22N2O4S/c24-12-6-14-30(27,28)17-20(16-21-15-19-9-4-5-10-22(19)29-21)23(26)25-13-11-18-7-2-1-3-8-18/h1-5,7-10,15-16H,6,11,13-14,17H2,(H,25,26) MKSRGRPJMWNWMF-UHFFFAOYSA-N 50647112 CHEMBL5595603 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647112&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378413 519662514 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605602 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCc1ccc(Oc2ccccc2)cc1 InChI=1S/C26H23BrN2O4S/c27-23-11-7-20(8-12-23)17-22(19-34(31,32)16-4-15-28)26(30)29-18-21-9-13-25(14-10-21)33-24-5-2-1-3-6-24/h1-3,5-14,17H,4,16,18-19H2,(H,29,30) IDOCDPMDYNTPNT-UHFFFAOYSA-N 50647113 CHEMBL5591334 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647113 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647113&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378414 519662515 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605603 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)N1CCC2(CC1)OCCO2 InChI=1S/C20H23BrN2O5S/c21-18-4-2-16(3-5-18)14-17(15-29(25,26)13-1-8-22)19(24)23-9-6-20(7-10-23)27-11-12-28-20/h2-5,14H,1,6-7,9-13,15H2 XIFLDPXPUOMCNT-UHFFFAOYSA-N 50647114 CHEMBL5591264 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647114&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378415 519662516 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605604 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NC1CCC(F)(F)CC1 InChI=1S/C19H21BrF2N2O3S/c20-16-4-2-14(3-5-16)12-15(13-28(26,27)11-1-10-23)18(25)24-17-6-8-19(21,22)9-7-17/h2-5,12,17H,1,6-9,11,13H2,(H,24,25) NMEDXSLLWSVHCM-UHFFFAOYSA-N 50647115 CHEMBL5583769 NACHT, LRR and PYD domains-containing protein 3 Human >10000 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647115&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378416 519662517 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605605 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1cccnc1 InChI=1S/C20H20BrN3O3S/c21-19-6-4-16(5-7-19)13-18(15-28(26,27)12-2-9-22)20(25)24-11-8-17-3-1-10-23-14-17/h1,3-7,10,13-14H,2,8,11-12,15H2,(H,24,25) LFFWFWSJCXJXEO-UHFFFAOYSA-N 50647116 CHEMBL5592483 NACHT, LRR and PYD domains-containing protein 3 Human 5030 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647116&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378417 519662518 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605606 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1ccncc1 InChI=1S/C20H20BrN3O3S/c21-19-4-2-17(3-5-19)14-18(15-28(26,27)13-1-9-22)20(25)24-12-8-16-6-10-23-11-7-16/h2-7,10-11,14H,1,8,12-13,15H2,(H,24,25) VLQADMHTMLLYHP-UHFFFAOYSA-N 50647117 CHEMBL5590187 NACHT, LRR and PYD domains-containing protein 3 Human 960 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647117&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378418 519662519 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605607 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1ccccc1F InChI=1S/C21H20BrFN2O3S/c22-19-8-6-16(7-9-19)14-18(15-29(27,28)13-3-11-24)21(26)25-12-10-17-4-1-2-5-20(17)23/h1-2,4-9,14H,3,10,12-13,15H2,(H,25,26) UFQOMDJHXLOHEB-UHFFFAOYSA-N 50647118 CHEMBL5592068 NACHT, LRR and PYD domains-containing protein 3 Human 1020 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647118&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378419 519662520 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605608 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1ccccc1Cl InChI=1S/C21H20BrClN2O3S/c22-19-8-6-16(7-9-19)14-18(15-29(27,28)13-3-11-24)21(26)25-12-10-17-4-1-2-5-20(17)23/h1-2,4-9,14H,3,10,12-13,15H2,(H,25,26) DKYHVJPUFQNAGN-UHFFFAOYSA-N 50647119 CHEMBL5590073 NACHT, LRR and PYD domains-containing protein 3 Human 710 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647119&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378420 519662521 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605609 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1ccccc1Br InChI=1S/C21H20Br2N2O3S/c22-19-8-6-16(7-9-19)14-18(15-29(27,28)13-3-11-24)21(26)25-12-10-17-4-1-2-5-20(17)23/h1-2,4-9,14H,3,10,12-13,15H2,(H,25,26) BFNCPVMQUUMBHB-UHFFFAOYSA-N 50647120 CHEMBL5590770 NACHT, LRR and PYD domains-containing protein 3 Human 680 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647120&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378421 519662522 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605610 COc1ccccc1CCNC(=O)/C(=C/c1ccc(Br)cc1)CS(=O)(=O)CCC#N InChI=1S/C22H23BrN2O4S/c1-29-21-6-3-2-5-18(21)11-13-25-22(26)19(16-30(27,28)14-4-12-24)15-17-7-9-20(23)10-8-17/h2-3,5-10,15H,4,11,13-14,16H2,1H3,(H,25,26) NMQTZDZRFKTMCH-UHFFFAOYSA-N 50647121 CHEMBL5591066 NACHT, LRR and PYD domains-containing protein 3 Human 260 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647121&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378422 519662523 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605611 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1cccc(F)c1 InChI=1S/C21H20BrFN2O3S/c22-19-7-5-17(6-8-19)13-18(15-29(27,28)12-2-10-24)21(26)25-11-9-16-3-1-4-20(23)14-16/h1,3-8,13-14H,2,9,11-12,15H2,(H,25,26) RUDLEPKYKFCFLU-UHFFFAOYSA-N 50647122 CHEMBL5595046 NACHT, LRR and PYD domains-containing protein 3 Human 4340 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647122&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378423 519662524 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605612 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1cccc(Cl)c1 InChI=1S/C21H20BrClN2O3S/c22-19-7-5-17(6-8-19)13-18(15-29(27,28)12-2-10-24)21(26)25-11-9-16-3-1-4-20(23)14-16/h1,3-8,13-14H,2,9,11-12,15H2,(H,25,26) AQGAFTVYKKSSBJ-UHFFFAOYSA-N 50647123 CHEMBL5591726 NACHT, LRR and PYD domains-containing protein 3 Human 430 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647123&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378424 519662525 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605613 N#CCCS(=O)(=O)C/C(=C\c1ccc(Br)cc1)C(=O)NCCc1cccc(Br)c1 InChI=1S/C21H20Br2N2O3S/c22-19-7-5-17(6-8-19)13-18(15-29(27,28)12-2-10-24)21(26)25-11-9-16-3-1-4-20(23)14-16/h1,3-8,13-14H,2,9,11-12,15H2,(H,25,26) DHLAOYRAKSKHDI-UHFFFAOYSA-N 50647124 CHEMBL5595030 NACHT, LRR and PYD domains-containing protein 3 Human 810 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647124&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378425 519662526 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605614 COc1cccc(CCNC(=O)/C(=C/c2ccc(Br)cc2)CS(=O)(=O)CCC#N)c1 InChI=1S/C22H23BrN2O4S/c1-29-21-5-2-4-17(15-21)10-12-25-22(26)19(16-30(27,28)13-3-11-24)14-18-6-8-20(23)9-7-18/h2,4-9,14-15H,3,10,12-13,16H2,1H3,(H,25,26) NDAZVORPCTXKHM-UHFFFAOYSA-N 50647125 CHEMBL5592969 NACHT, LRR and PYD domains-containing protein 3 Human 1880 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647125&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378426 519662527 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605615 N#CCCSC/C(=C\c1ccc(Cl)cc1)C(=O)NCCc1ccccc1 InChI=1S/C21H21ClN2OS/c22-20-9-7-18(8-10-20)15-19(16-26-14-4-12-23)21(25)24-13-11-17-5-2-1-3-6-17/h1-3,5-10,15H,4,11,13-14,16H2,(H,24,25) WWJSUWDOZKWOSU-UHFFFAOYSA-N 50647126 CHEMBL5592009 NACHT, LRR and PYD domains-containing protein 3 Human 17400 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647126 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647126&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378427 519662528 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605616 CC(C)(c1cc(oc1)S(=O)(=O)NC(=O)Nc2c3c(cc4c2CCC4)CCC3)O InChI=1S/C20H24N2O5S/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23) HUUSXLKCTQDPGL-UHFFFAOYSA-N 50155926 CHEMBL3183703 NACHT, LRR and PYD domains-containing protein 3 Homo sapiens 12 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50155926 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50155926&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 8GI 7PZC 9910393 340133725 CHEMBL3183703 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605617 Clc1ccc(\C=C\C(=O)NCCc2ccccc2)cc1 InChI=1S/C17H16ClNO/c18-16-9-6-15(7-10-16)8-11-17(20)19-13-12-14-4-2-1-3-5-14/h1-11H,12-13H2,(H,19,20) UIVHFGGSZLLTNW-UHFFFAOYSA-N 50069774 (2E)-3-(4-chlorophenyl)-N-(2-phenylethyl)acrylamide::(E)-3-(4-Chloro-phenyl)-N-phenethyl-acrylamide::CHEMBL62044 NACHT, LRR and PYD domains-containing protein 3 Homo sapiens 27300 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50069774 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50069774&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 692389 103963776 CHEMBL62044 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605618 COc1ccccc1CCNC(=O)/C(=C/c1ccc(Br)cc1)CS(=O)(=O)CCC#N InChI=1S/C22H23BrN2O4S/c1-29-21-6-3-2-5-18(21)11-13-25-22(26)19(16-30(27,28)14-4-12-24)15-17-7-9-20(23)10-8-17/h2-3,5-10,15H,4,11,13-14,16H2,1H3,(H,25,26) NMQTZDZRFKTMCH-UHFFFAOYSA-N 50647121 CHEMBL5591066 NACHT, LRR and PYD domains-containing protein 3 Human 1050 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647121&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378422 519662523 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9 51605619 COc1ccccc1CCNC(=O)/C(=C/c1ccc(Br)cc1)CS(=O)(=O)CCC#N InChI=1S/C22H23BrN2O4S/c1-29-21-6-3-2-5-18(21)11-13-25-22(26)19(16-30(27,28)14-4-12-24)15-17-7-9-20(23)10-8-17/h2-3,5-10,15H,4,11,13-14,16H2,1H3,(H,25,26) NMQTZDZRFKTMCH-UHFFFAOYSA-N 50647121 CHEMBL5591066 NACHT, LRR and PYD domains-containing protein 3 Mouse 210 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007070&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647121&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378422 519662523 1 MTSVRCKLAQYLEDLEDVDLKKFKMHLEDYPPEKGCIPVPRGQMEKADHLDLATLMIDFNGEEKAWAMAVWIFAAINRRDLWEKAKKDQPEWNDTCTSHSSMVCQEDSLEEEWMGLLGYLSRISICKKKKDYCKMYRRHVRSRFYSIKDRNARLGESVDLNSRYTQLQLVKEHPSKQEREHELLTIGRTKMRDSPMSSLKLELLFEPEDGHSEPVHTVVFQGAAGIGKTILARKIMLDWALGKLFKDKFDYLFFIHCREVSLRTPRSLADLIVSCWPDPNPPVCKILRKPSRILFLMDGFDELQGAFDEHIGEVCTDWQKAVRGDILLSSLIRKKLLPKASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSNELQAREAFRLIQENEVLFTMCFIPLVCWIVCTGLKQQMETGKSLAQTSKTTTAVYVFFLSSLLQSRGGIEEHLFSDYLQGLCSLAADGIWNQKILFEECDLRKHGLQKTDVSAFLRMNVFQKEVDCERFYSFSHMTFQEFFAAMYYLLEEEAEGETVRKGPGGCSDLLNRDVKVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQVRLELLKWIEVKAKAKKLQWQPSQLELFYCLYEMQEEDFVQSAMDHFPKIEINLSTRMDHVVSSFCIKNCHRVKTLSLGFFHNSPKEEEEERRGGRPLDQVQCVFPDTHVACSSRLVNCCLTSSFCRGLFSSLSTNRSLTELDLSDNTLGDPGMRVLCEALQHPGCNIQRLWLGRCGLSHQCCFDISSVLSSSQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLQKLWLVSCCLTSACCQDLALVLSSNHSLTRLYIGENALGDSGVQVLCEKMKDPQCNLQKLGLVNSGLTSICCSALTSVLKTNQNFTHLYLRSNALGDTGLRLLCEGLLHPDCKLQMLELDNCSLTSHSCWNLSTILTHNHSLRKLNLGNNDLGDLCVVTLCEVLKQQGCLLQSLQLGEMYLNRETKRALEALQEEKPELTIVFEISW 7LFH,7VTQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_MOUSE Q8R4B8 Q1JQ87 Q1JQ88 Q6JEL0 T1W2H6 51605620 COc1ccccc1CCNC(=O)/C(=C/c1ccc(Br)cc1)CS(=O)(=O)CCC#N InChI=1S/C22H23BrN2O4S/c1-29-21-6-3-2-5-18(21)11-13-25-22(26)19(16-30(27,28)14-4-12-24)15-17-7-9-20(23)10-8-17/h2-3,5-10,15H,4,11,13-14,16H2,1H3,(H,25,26) NMQTZDZRFKTMCH-UHFFFAOYSA-N 50647121 CHEMBL5591066 NACHT, LRR and PYD domains-containing protein 3 Human 260 ChEMBL 10.7270/Q2SF31V0 39269610 Zhang, Z; Wu, H; Yin, K; Zheng, X; Cao, Z; Guo, W; Zhao, C; Gu, X //0 10/12/2025 Fudan University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50647121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4827&target=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50647121&enzyme=NACHT%2C+LRR+and+PYD+domains-containing+protein+3&column=ki&startPg=0&Increment=50&submit=Search 177378422 519662523 1 MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPSW 9MIG,9MIE,9MGY,7PZC,7ZGU,8SWF,8EJ4,9SFG,9HG4,9GU4,8ZEM,8WSM,8RI2,7ALV,8ETR,3QF2,8ERT,2NAQ NACHT, LRR and PYD domains-containing protein 3 NLRP3_HUMAN Q96P20 A0A024R5Q0 B2RC97 B7ZKS9 B7ZKT2 B7ZKT3 O75434 Q17RS2 Q59H68 Q5JQS8 Q5JQS9 Q6TG35 Q8TCW0 Q8TEU9 Q8WXH9