BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
77705	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C15H12F2N4O3S2/c1-21(8-14(22)18-9-5-6-10(16)11(17)7-9)26(23,24)13-4-2-3-12-15(13)20-25-19-12/h2-7H,8H2,1H3,(H,18,22)	FXHPOKRVZPKWCI-UHFFFAOYSA-N	42346	1-(2-(4- cyclopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 1	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42346&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3240958	252623050							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77706	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C15H12F2N4O3S2/c1-21(8-14(22)18-9-5-6-10(16)11(17)7-9)26(23,24)13-4-2-3-12-15(13)20-25-19-12/h2-7H,8H2,1H3,(H,18,22)	FXHPOKRVZPKWCI-UHFFFAOYSA-N	42346	1-(2-(4- cyclopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 1	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42346&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3240958	252623050							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77707	C=CC(=O)N1CCc2nn(-c3ccc(CC(F)(F)F)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2[nH]cnc12)CC3	InChI=1S/C18H17N3O4S/c22-17(21-11-4-6-13-5-1-2-8-15(13)21)10-12-26(23,24)16-9-3-7-14-18(16)20-25-19-14/h1-3,5,7-9H,4,6,10-12H2	HNQOFOMKBWSKLP-UHFFFAOYSA-N	42348	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-(2,2,2- trifluoroethyl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 2	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42348&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3241325	252623052							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77708	C=CC(=O)N1CCc2nn(-c3ccc(CC(F)(F)F)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2[nH]cnc12)CC3	InChI=1S/C18H17N3O4S/c22-17(21-11-4-6-13-5-1-2-8-15(13)21)10-12-26(23,24)16-9-3-7-14-18(16)20-25-19-14/h1-3,5,7-9H,4,6,10-12H2	HNQOFOMKBWSKLP-UHFFFAOYSA-N	42348	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-(2,2,2- trifluoroethyl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 2	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42348	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42348&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3241325	252623052							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77709	C=CC(=O)N1CCc2nn(-c3ccc(C(F)(F)F)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C14H23N7O/c15-11(19-22)12-16-13(20-7-3-1-4-8-20)18-14(17-12)21-9-5-2-6-10-21/h22H,1-10H2,(H2,15,19)	DJTPXVULNONQRD-UHFFFAOYSA-N	42349	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4- (trifluoromethyl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 3	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42349&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5771411	252623053							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77710	C=CC(=O)N1CCc2nn(-c3ccc(C(F)(F)F)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C14H23N7O/c15-11(19-22)12-16-13(20-7-3-1-4-8-20)18-14(17-12)21-9-5-2-6-10-21/h22H,1-10H2,(H2,15,19)	DJTPXVULNONQRD-UHFFFAOYSA-N	42349	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4- (trifluoromethyl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 3	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42349&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5771411	252623053							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77711	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H14N2O/c1-10(16-18)11-7-8-13-12-5-3-4-6-14(12)17(2)15(13)9-11/h3-10H,1-2H3	UBTRXBCRDWVRER-UHFFFAOYSA-N	42350	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)-5-(7-bromo- 1H-benzo[d]imidazole- 4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 4	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42350&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896532	252623054							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77712	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H14N2O/c1-10(16-18)11-7-8-13-12-5-3-4-6-14(12)17(2)15(13)9-11/h3-10H,1-2H3	UBTRXBCRDWVRER-UHFFFAOYSA-N	42350	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)-5-(7-bromo- 1H-benzo[d]imidazole- 4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 4	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42350&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896532	252623054							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77713	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C18H17ClN4O2/c1-12-3-2-9-23-17(12)22-16(20-8-10-24)15(18(23)25)11-21-14-6-4-13(19)5-7-14/h2-7,9,11,20,24H,8,10H2,1H3	GBOOMRLVNXMOQM-UHFFFAOYSA-N	42351	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 5	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42351&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5310466	252623055							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77714	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C18H17ClN4O2/c1-12-3-2-9-23-17(12)22-16(20-8-10-24)15(18(23)25)11-21-14-6-4-13(19)5-7-14/h2-7,9,11,20,24H,8,10H2,1H3	GBOOMRLVNXMOQM-UHFFFAOYSA-N	42351	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 5	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42351&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5310466	252623055							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77715	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4(F)F)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C19H19NO5S/c1-14-5-2-3-6-15(14)12-26(22,23)13-17-8-9-18(25-17)19(21)20-11-16-7-4-10-24-16/h2-10H,11-13H2,1H3,(H,20,21)	ALVHKHRIFNKTMS-UHFFFAOYSA-N	42352	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4-(2,2- difluorocyclobutyl)-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 6	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42352&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3242263	252623056							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77716	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4(F)F)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C19H19NO5S/c1-14-5-2-3-6-15(14)12-26(22,23)13-17-8-9-18(25-17)19(21)20-11-16-7-4-10-24-16/h2-10H,11-13H2,1H3,(H,20,21)	ALVHKHRIFNKTMS-UHFFFAOYSA-N	42352	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4-(2,2- difluorocyclobutyl)-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 6	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42352&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3242263	252623056							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77717	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C9H12N4O2S/c1-4(2)13-5-6(10-9(13)16)12(3)8(15)11-7(5)14/h4H,1-3H3,(H,10,16)(H,11,14,15)	BIPXEDYGKRHJHF-UHFFFAOYSA-N	42353	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 7	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42353&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			840403	252623057							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77718	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C9H12N4O2S/c1-4(2)13-5-6(10-9(13)16)12(3)8(15)11-7(5)14/h4H,1-3H3,(H,10,16)(H,11,14,15)	BIPXEDYGKRHJHF-UHFFFAOYSA-N	42353	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 7	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42353&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			840403	252623057							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77719	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(N)N=2)CC3	InChI=1S/C15H15N3O2S2/c1-10-7-8-11(2)13(9-10)18(3)22(19,20)14-6-4-5-12-15(14)17-21-16-12/h4-9H,1-3H3	PLEKKJCSEZQOQM-UHFFFAOYSA-N	42354	1-(5-(2-amino-7-bromo- 1H-benzo[d]imidazole- 4-carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 8	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42354&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3242355	252623058							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77720	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(N)N=2)CC3	InChI=1S/C15H15N3O2S2/c1-10-7-8-11(2)13(9-10)18(3)22(19,20)14-6-4-5-12-15(14)17-21-16-12/h4-9H,1-3H3	PLEKKJCSEZQOQM-UHFFFAOYSA-N	42354	1-(5-(2-amino-7-bromo- 1H-benzo[d]imidazole- 4-carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 8	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42354&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3242355	252623058							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77721	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(N1CCC1)N=2)CC3	InChI=1S/C21H25N5O3S2/c27-20(23-17-10-13-26(14-11-17)15-16-5-2-1-3-6-16)9-12-22-31(28,29)19-8-4-7-18-21(19)25-30-24-18/h1-8,17,22H,9-15H2,(H,23,27)	IJLHTKMSXQEBQG-UHFFFAOYSA-N	42355	1-(5-(2-(azetidin-1-yl)-7- bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 9	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42355&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3242583	252623059							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77722	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(N1CCC1)N=2)CC3	InChI=1S/C21H25N5O3S2/c27-20(23-17-10-13-26(14-11-17)15-16-5-2-1-3-6-16)9-12-22-31(28,29)19-8-4-7-18-21(19)25-30-24-18/h1-8,17,22H,9-15H2,(H,23,27)	IJLHTKMSXQEBQG-UHFFFAOYSA-N	42355	1-(5-(2-(azetidin-1-yl)-7- bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 9	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42355&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3242583	252623059							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77723	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ncc(Br)c2c1=NCN=2)CC3	InChI=1S/C19H22N2O4S/c1-14-5-8-16(9-6-14)26(24,25)20-17-13-15(19(22)23)7-10-18(17)21-11-3-2-4-12-21/h5-10,13,20H,2-4,11-12H2,1H3,(H,22,23)	OFMWCZQKDYLGRA-UHFFFAOYSA-N	42356	1-(5-(7-bromo-1H- imidazo[4,5-c]pyridine- 4-carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 10	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42356&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3242990	252623060							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77724	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ncc(Br)c2c1=NCN=2)CC3	InChI=1S/C19H22N2O4S/c1-14-5-8-16(9-6-14)26(24,25)20-17-13-15(19(22)23)7-10-18(17)21-11-3-2-4-12-21/h5-10,13,20H,2-4,11-12H2,1H3,(H,22,23)	OFMWCZQKDYLGRA-UHFFFAOYSA-N	42356	1-(5-(7-bromo-1H- imidazo[4,5-c]pyridine- 4-carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 10	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42356&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3242990	252623060							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77725	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc2c(cnn2C(F)(F)F)c1)CC3	InChI=1S/C13H15ClN4O/c14-11-2-4-12(5-3-11)17-13(19)16-6-1-8-18-9-7-15-10-18/h2-5,7,9-10H,1,6,8H2,(H2,16,17,19)	SNQYQRBZLIAPFA-UHFFFAOYSA-N	42357	1-(2-(4- isopropylphenyl)-5-(1- (trifluoromethyl)-1H- indazole-5-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 11	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42357&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2804810	252623061							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77726	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(OC)c1)CC3	InChI=1S/C20H37N3O3/c1-15(2)18(22-19(24)17-7-5-16(3)6-8-17)20(25)21-9-4-10-23-11-13-26-14-12-23/h15-18H,4-14H2,1-3H3,(H,21,25)(H,22,24)	DUKYVKPIHXPZSU-UHFFFAOYSA-N	42358	1-(2-(4- isopropylphenyl)-5-(5- methoxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 12	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42358&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243058	252623062							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77727	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(OC)c1)CC3	InChI=1S/C20H37N3O3/c1-15(2)18(22-19(24)17-7-5-16(3)6-8-17)20(25)21-9-4-10-23-11-13-26-14-12-23/h15-18H,4-14H2,1-3H3,(H,21,25)(H,22,24)	DUKYVKPIHXPZSU-UHFFFAOYSA-N	42358	1-(2-(4- isopropylphenyl)-5-(5- methoxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 12	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42358&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243058	252623062							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77728	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1)CC3	InChI=1S/C27H35N3O5/c1-15(2)30-23(25(32)29-19-11-6-5-8-16(19)3)27-13-12-20(35-27)21(22(27)26(30)33)24(31)28-17-9-7-10-18(14-17)34-4/h7,9-10,12-16,19-23H,5-6,8,11H2,1-4H3,(H,28,31)(H,29,32)	RZFCFNKCEHOXSQ-UHFFFAOYSA-N	42359	1-(2-(4- isopropylphenyl)-5-(6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 13	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42359&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243229	242053019							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77729	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1)CC3	InChI=1S/C27H35N3O5/c1-15(2)30-23(25(32)29-19-11-6-5-8-16(19)3)27-13-12-20(35-27)21(22(27)26(30)33)24(31)28-17-9-7-10-18(14-17)34-4/h7,9-10,12-16,19-23H,5-6,8,11H2,1-4H3,(H,28,31)(H,29,32)	RZFCFNKCEHOXSQ-UHFFFAOYSA-N	42359	1-(2-(4- isopropylphenyl)-5-(6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 13	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42359&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243229	242053019							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77730	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C19H20N6O2/c1-13-5-3-9-25-16(13)22-17-14(19(25)27)11-15(23(17)2)18(26)21-6-4-8-24-10-7-20-12-24/h3,5,7,9-12H,4,6,8H2,1-2H3,(H,21,26)	RBIMOCNCXCOONR-UHFFFAOYSA-N	42360	1-(5-(5-hydroxy-6- (trifluoromethyl) nicotinoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 14	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42360&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243418	242053020							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77731	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C19H20N6O2/c1-13-5-3-9-25-16(13)22-17-14(19(25)27)11-15(23(17)2)18(26)21-6-4-8-24-10-7-20-12-24/h3,5,7,9-12H,4,6,8H2,1-2H3,(H,21,26)	RBIMOCNCXCOONR-UHFFFAOYSA-N	42360	1-(5-(5-hydroxy-6- (trifluoromethyl) nicotinoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 14	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42360&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243418	242053020							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77732	CC(C)c1ccc(-n2nc3c4c2CCN(C(=O)c2ccc(Br)c5[nH]cnc25)C4CN(C(=O)/C=C/CN(C)C)CC3)cc1	InChI=1S/C17H19N3O5S/c1-3-12-14(22)19-17(20-15(12)23)26-9-13(21)18-11-7-5-10(6-8-11)16(24)25-4-2/h5-8H,3-4,9H2,1-2H3,(H,18,21)(H2,19,20,22,23)	LISVZTXIASWGBH-UHFFFAOYSA-N	42361	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)-4- (dimethylamino)but-2- en-1-one::US20250346600, Compound 15	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42361&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16469660	252623063							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77733	CC(C)c1ccc(-n2nc3c4c2CCN(C(=O)c2ccc(Br)c5[nH]cnc25)C4CN(C(=O)/C=C/CN(C)C)CC3)cc1	InChI=1S/C17H19N3O5S/c1-3-12-14(22)19-17(20-15(12)23)26-9-13(21)18-11-7-5-10(6-8-11)16(24)25-4-2/h5-8H,3-4,9H2,1-2H3,(H,18,21)(H2,19,20,22,23)	LISVZTXIASWGBH-UHFFFAOYSA-N	42361	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)-4- (dimethylamino)but-2- en-1-one::US20250346600, Compound 15	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42361&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16469660	252623063							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77734	CC(C)c1ccc(-n2nc3c4c2CCN(C(=O)c2ccc(Br)c5c2=NCN=5)C4CN(C(=O)C2=CCC2)CC3)cc1	InChI=1S/C22H33N3O5/c1-5-8-12-24(4)20(26)11-9-10-13-25-21(27)16-14-18(29-6-2)19(30-7-3)15-17(16)23-22(25)28/h14-15H,5-13H2,1-4H3,(H,23,28)	YRSQJPGULPLBJK-UHFFFAOYSA-N	42362	(7-bromo-1H- benzo[d]imidazol-4- yl)(7-(cyclobut-1-ene-1- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5a,6,7,8,9- octahydro-5H-1,2,5,7- tetraazabenzo[cd]azulen- 5-yl)methanone::US20250346600, Compound 16	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42362&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243769	252623064							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77735	C=C(F)C(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C23H24N4O4S/c1-2-31-23(30)26-12-10-25(11-13-26)20(28)17-8-9-18-19(14-17)24-22(32)27(21(18)29)15-16-6-4-3-5-7-16/h3-9,14H,2,10-13,15H2,1H3,(H,24,32)	HYBXAFNJZDBIEH-UHFFFAOYSA-N	42363	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)-2-fluoroprop-2-en- 1-one::US20250346600, Compound 17	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42363&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243888	252623065							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77736	C=C(F)C(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C23H24N4O4S/c1-2-31-23(30)26-12-10-25(11-13-26)20(28)17-8-9-18-19(14-17)24-22(32)27(21(18)29)15-16-6-4-3-5-7-16/h3-9,14H,2,10-13,15H2,1H3,(H,24,32)	HYBXAFNJZDBIEH-UHFFFAOYSA-N	42363	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)-2-fluoroprop-2-en- 1-one::US20250346600, Compound 17	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42363&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3243888	252623065							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77737	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C#N)c2c1=NCN=2)CC3	InChI=1S/C17H19NO4/c1-21-14-9-5-8-12-10-13(17(20)22-15(12)14)18-16(19)11-6-3-2-4-7-11/h5,8-11H,2-4,6-7H2,1H3,(H,18,19)	WVUQUXZEAUCRBK-UHFFFAOYSA-N	42364	4-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-1H- benzo[d]imidazole-7- carbonitrile::US20250346600, Compound 18	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42364&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3244097	252623066							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77738	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C#N)c2c1=NCN=2)CC3	InChI=1S/C17H19NO4/c1-21-14-9-5-8-12-10-13(17(20)22-15(12)14)18-16(19)11-6-3-2-4-7-11/h5,8-11H,2-4,6-7H2,1H3,(H,18,19)	WVUQUXZEAUCRBK-UHFFFAOYSA-N	42364	4-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-1H- benzo[d]imidazole-7- carbonitrile::US20250346600, Compound 18	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42364&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3244097	252623066							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77739	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2[nH]ncc12)CC3	InChI=1S/C17H24N4O4S2/c1-4-6-11-21(5-2)27(23,24)14-9-7-13(8-10-14)16(22)18-17-20-19-15(25-17)12-26-3/h7-10H,4-6,11-12H2,1-3H3,(H,18,20,22)	ZDFGBFFUUMQLKE-UHFFFAOYSA-N	42365	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)-5-(7- (trifluoromethyl)-1H- indazole-4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 19	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42365&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2155641	252623067							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77740	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2[nH]ncc12)CC3	InChI=1S/C17H24N4O4S2/c1-4-6-11-21(5-2)27(23,24)14-9-7-13(8-10-14)16(22)18-17-20-19-15(25-17)12-26-3/h7-10H,4-6,11-12H2,1-3H3,(H,18,20,22)	ZDFGBFFUUMQLKE-UHFFFAOYSA-N	42365	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)-5-(7- (trifluoromethyl)-1H- indazole-4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 19	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42365&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2155641	252623067							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77741	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C21H22N4O4S/c26-18-5-1-9-24(18)10-3-8-22-19(27)14-6-7-16-17(12-14)23-21(30)25(20(16)28)13-15-4-2-11-29-15/h2,4,6-7,11-12H,1,3,5,8-10,13H2,(H,22,27)(H,23,30)	DVGXHXCVIQKHOH-UHFFFAOYSA-N	42366	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 20	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42366&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3244211	252623068							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77742	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C21H22N4O4S/c26-18-5-1-9-24(18)10-3-8-22-19(27)14-6-7-16-17(12-14)23-21(30)25(20(16)28)13-15-4-2-11-29-15/h2,4,6-7,11-12H,1,3,5,8-10,13H2,(H,22,27)(H,23,30)	DVGXHXCVIQKHOH-UHFFFAOYSA-N	42366	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 20	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42366&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3244211	252623068							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77743	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C22H22N4O3S/c1-25-20-8-4-3-7-19(20)24-22(25)18(15-23)21(27)16-9-11-17(12-10-16)30(28,29)26-13-5-2-6-14-26/h3-4,7-12,18H,2,5-6,13-14H2,1H3	VGTHFJOPFAKNJC-UHFFFAOYSA-N	42367	1-(2-(2-hydroxy-4- isopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 21	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42367&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			24156856	252623069							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77744	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C22H22N4O3S/c1-25-20-8-4-3-7-19(20)24-22(25)18(15-23)21(27)16-9-11-17(12-10-16)30(28,29)26-13-5-2-6-14-26/h3-4,7-12,18H,2,5-6,13-14H2,1H3	VGTHFJOPFAKNJC-UHFFFAOYSA-N	42367	1-(2-(2-hydroxy-4- isopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 21	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42367&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			24156856	252623069							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77745	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)C1=C2N=CN=C2C(Br)=NC1)CC3	InChI=1S/C24H26N4O3/c1-18-15-19-7-5-6-10-21(19)24(31)28(18)17-22(29)25-16-23(30)27-13-11-26(12-14-27)20-8-3-2-4-9-20/h2-10,15H,11-14,16-17H2,1H3,(H,25,29)	KTPSKHJLDGYFCP-UHFFFAOYSA-N	42368	1-(5-(4-bromo-3H- imidazo[4,5-c]pyridine- 7-carbonyl)-2-(2- hydroxy-4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 22	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42368&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3244436	252623070							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77746	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)C1=C2N=CN=C2C(Br)=NC1)CC3	InChI=1S/C24H26N4O3/c1-18-15-19-7-5-6-10-21(19)24(31)28(18)17-22(29)25-16-23(30)27-13-11-26(12-14-27)20-8-3-2-4-9-20/h2-10,15H,11-14,16-17H2,1H3,(H,25,29)	KTPSKHJLDGYFCP-UHFFFAOYSA-N	42368	1-(5-(4-bromo-3H- imidazo[4,5-c]pyridine- 7-carbonyl)-2-(2- hydroxy-4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 22	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42368&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3244436	252623070							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77747	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C16H20N2O4S/c1-2-21-14-7-8-15(13-6-3-9-17-16(13)14)23(19,20)18-11-12-5-4-10-22-12/h3,6-9,12,18H,2,4-5,10-11H2,1H3	HCPHVOHKWUYTAO-UHFFFAOYSA-N	42370	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 23	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42370&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3244767	252623072							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77748	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C16H20N2O4S/c1-2-21-14-7-8-15(13-6-3-9-17-16(13)14)23(19,20)18-11-12-5-4-10-22-12/h3,6-9,12,18H,2,4-5,10-11H2,1H3	HCPHVOHKWUYTAO-UHFFFAOYSA-N	42370	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 23	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42370&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3244767	252623072							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77749	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc2c(Br)[nH]nc2c1)CC3	InChI=1S/C21H22N6O3/c1-4-30-16-11-7-5-9-14(16)19-18(13(2)22-21-24-25-26-27(19)21)20(28)23-15-10-6-8-12-17(15)29-3/h5-12,18-19H,4H2,1-3H3,(H,23,28)	WLHXMSIXHBKGDB-UHFFFAOYSA-N	42371	1-(5-(3-bromo-1H- indazole-6-carbonyl)-2- (4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 24	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42371&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896533	252623073							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77750	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc2c(Br)[nH]nc2c1)CC3	InChI=1S/C21H22N6O3/c1-4-30-16-11-7-5-9-14(16)19-18(13(2)22-21-24-25-26-27(19)21)20(28)23-15-10-6-8-12-17(15)29-3/h5-12,18-19H,4H2,1-3H3,(H,23,28)	WLHXMSIXHBKGDB-UHFFFAOYSA-N	42371	1-(5-(3-bromo-1H- indazole-6-carbonyl)-2- (4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 24	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42371&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896533	252623073							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77751	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C18H15Cl2N3O3/c19-13-8-7-11(9-14(13)20)23-17(25)22-15-4-2-1-3-12(15)18(23,26)16(24)21-10-5-6-10/h1-4,7-10,26H,5-6H2,(H,21,24)(H,22,25)	JKXNEWQEOGIYSJ-UHFFFAOYSA-N	42372	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 25	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42372&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3245305	252623074							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77752	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C18H15Cl2N3O3/c19-13-8-7-11(9-14(13)20)23-17(25)22-15-4-2-1-3-12(15)18(23,26)16(24)21-10-5-6-10/h1-4,7-10,26H,5-6H2,(H,21,24)(H,22,25)	JKXNEWQEOGIYSJ-UHFFFAOYSA-N	42372	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 25	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42372&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3245305	252623074							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77753	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C12H13NO3S/c1-2-16-12(15)7-13-9-5-3-4-6-10(9)17-8-11(13)14/h3-6H,2,7-8H2,1H3	SVCWFHUVHSQFAD-UHFFFAOYSA-N	42374	1-(2-(4- cyclobutylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 26	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42374&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3245459	252623076							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77754	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C12H13NO3S/c1-2-16-12(15)7-13-9-5-3-4-6-10(9)17-8-11(13)14/h3-6H,2,7-8H2,1H3	SVCWFHUVHSQFAD-UHFFFAOYSA-N	42374	1-(2-(4- cyclobutylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 26	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42374&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3245459	252623076							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77755	C=CC(=O)N1CC(OC)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C11H8N2O5/c14-9-4-10(15)13(11(16)12-9)6-1-2-7-8(3-6)18-5-17-7/h1-4,15H,5H2,(H,12,14,16)	ZINZWUGEQBZXBA-UHFFFAOYSA-N	42375	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)-9- methoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 27	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42375&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1526963	252623077							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77756	C=CC(=O)N1CC(OC)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C11H8N2O5/c14-9-4-10(15)13(11(16)12-9)6-1-2-7-8(3-6)18-5-17-7/h1-4,15H,5H2,(H,12,14,16)	ZINZWUGEQBZXBA-UHFFFAOYSA-N	42375	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)-9- methoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 27	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42375&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1526963	252623077							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77757	C=CC(=O)N1CC(F)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H21NO2/c1-4-9-16-15(17)6-5-10-18-14-11-12(2)7-8-13(14)3/h4,7-8,11H,1,5-6,9-10H2,2-3H3,(H,16,17)	STYCGUFAPQLLLC-UHFFFAOYSA-N	42377	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)-9- fluoro-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 28	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42377&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1570484	252623079							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77758	C=CC(=O)N1CC(F)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H21NO2/c1-4-9-16-15(17)6-5-10-18-14-11-12(2)7-8-13(14)3/h4,7-8,11H,1,5-6,9-10H2,2-3H3,(H,16,17)	STYCGUFAPQLLLC-UHFFFAOYSA-N	42377	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)-9- fluoro-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 28	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42377&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1570484	252623079							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77759	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)nc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H21N3O/c1-11-8-12(10-19-2)14(9-16)15(17-11)18-13-6-4-3-5-7-13/h8,13H,3-7,10H2,1-2H3,(H,17,18)	QJWCTDCYFSLQAW-UHFFFAOYSA-N	42378	1-(2-(6- (bicyclo[1.1.1]pentan-1- yl)pyridin-3-yl)-5-(7- bromo-1H- benzo[d]imidazole-4- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 29	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42378&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			886683	252623080							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77760	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)nc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H21N3O/c1-11-8-12(10-19-2)14(9-16)15(17-11)18-13-6-4-3-5-7-13/h8,13H,3-7,10H2,1-2H3,(H,17,18)	QJWCTDCYFSLQAW-UHFFFAOYSA-N	42378	1-(2-(6- (bicyclo[1.1.1]pentan-1- yl)pyridin-3-yl)-5-(7- bromo-1H- benzo[d]imidazole-4- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 29	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42378&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			886683	252623080							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77761	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3F)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C13H12N4O2S/c1-8-6-11(17-19-8)16-12(18)7-20-13-14-9-4-2-3-5-10(9)15-13/h2-6H,7H2,1H3,(H,14,15)(H,16,17,18)	ALVRSIIVBMUCBC-UHFFFAOYSA-N	42379	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)-2-fluorophenyl)-5-(7- bromo-1H- benzo[d]imidazole-4- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 30	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42379&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			684683	252623081							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77762	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3F)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C13H12N4O2S/c1-8-6-11(17-19-8)16-12(18)7-20-13-14-9-4-2-3-5-10(9)15-13/h2-6H,7H2,1H3,(H,14,15)(H,16,17,18)	ALVRSIIVBMUCBC-UHFFFAOYSA-N	42379	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)-2-fluorophenyl)-5-(7- bromo-1H- benzo[d]imidazole-4- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 30	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42379&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			684683	252623081							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77763	C=CC(=O)N1CC(C)c2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C14H15NO2/c1-8-7-12(16)17-14-10-4-3-5-15-13(10)9(2)6-11(8)14/h6-7,15H,3-5H2,1-2H3	HNBLXGUKCHVXSO-UHFFFAOYSA-N	42380	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 31	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42380&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			760021	252623082							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77764	C=CC(=O)N1CC(C)c2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C14H15NO2/c1-8-7-12(16)17-14-10-4-3-5-15-13(10)9(2)6-11(8)14/h6-7,15H,3-5H2,1-2H3	HNBLXGUKCHVXSO-UHFFFAOYSA-N	42380	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 31	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42380&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			760021	252623082							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77765	C=CC(=O)N1CC(C)c2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C14H13N3OS/c19-14-16-15-13(9-11-5-2-1-3-6-11)17(14)10-12-7-4-8-18-12/h1-8H,9-10H2,(H,16,19)	KXLVXORPOHNALY-UHFFFAOYSA-N	42381	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 32	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42381&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			891086	252623083							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77766	C=CC(=O)N1CC(C)c2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C14H13N3OS/c19-14-16-15-13(9-11-5-2-1-3-6-11)17(14)10-12-7-4-8-18-12/h1-8H,9-10H2,(H,16,19)	KXLVXORPOHNALY-UHFFFAOYSA-N	42381	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 32	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42381&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			891086	252623083							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77767	C=CC(=O)N1CC(C)c2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C18H18Cl2N2O/c19-15-4-1-3-13(18(15)20)10-21-8-12-7-14(11-21)16-5-2-6-17(23)22(16)9-12/h1-6,12,14H,7-11H2	QEEIYTFWZSCOSS-UHFFFAOYSA-N	42382	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 33	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42382&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2857421	242053021							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77768	C=CC(=O)N1CC(C)c2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C18H18Cl2N2O/c19-15-4-1-3-13(18(15)20)10-21-8-12-7-14(11-21)16-5-2-6-17(23)22(16)9-12/h1-6,12,14H,7-11H2	QEEIYTFWZSCOSS-UHFFFAOYSA-N	42382	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 33	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42382&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2857421	242053021							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77769	C=CC(=O)N1CC(C)c2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H16N2O3S2/c1-8-12(14(19)20-2)22-15(16-8)17-13(18)10-7-21-11-6-4-3-5-9(10)11/h7H,3-6H2,1-2H3,(H,16,17,18)	OILVDCAEQZNVRB-UHFFFAOYSA-N	42383	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 34	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42383&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1245230	252623084							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77770	C=CC(=O)N1CC(C)c2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H16N2O3S2/c1-8-12(14(19)20-2)22-15(16-8)17-13(18)10-7-21-11-6-4-3-5-9(10)11/h7H,3-6H2,1-2H3,(H,16,17,18)	OILVDCAEQZNVRB-UHFFFAOYSA-N	42383	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 34	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42383&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1245230	252623084							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77771	C=CC(=O)N1Cc2nn(-c3ccc(C(C)C)cc3C)c3c2C(C1)N(C(=O)c1ccc(Br)c(O)c1)CC3	InChI=1S/C19H18N2O4S/c1-23-15-7-3-13(4-8-15)11-18-20-21-19(25-18)26-12-17(22)14-5-9-16(24-2)10-6-14/h3-10H,11-12H2,1-2H3	KHJHWKRZUOKNDJ-UHFFFAOYSA-N	42386	1-(6-(4-bromo-3- hydroxybenzoyl)-1-(4- isopropyl-2- methylphenyl)- 1,5,5a,6,7,8- hexahydropyrazolo[3,4,5- de][1,7]naphthyridin- 4(3H)-yl)prop-2-en-1- one::US20250346600, Compound 35	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42386&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1076534	252623087							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77772	C=CC(=O)N1CCOCc2nn(-c3ccc(C(C)C)cc3C)c3c2C(C1)N(C(=O)c1ccc(Br)c(O)c1)CC3	InChI=1S/C21H17N3O5/c1-3-28-21(27)19-16(17(26)14-9-10-15(25)12(2)18(14)29-19)20-23-22-11-24(20)13-7-5-4-6-8-13/h4-11,25H,3H2,1-2H3	CMKBGPWAWMYNPK-UHFFFAOYSA-N	42387	1-(5-(4-bromo-3- hydroxybenzoyl)-2-(4- isopropyl-2- methylphenyl)- 2,4,5,5a,6,8,9,11- octahydro-10-oxa- 1,2,5,7- tetraazacyclonona[cd] inden-7(3H)-yl)prop-2-en- 1-one::US20250346600, Compound 36	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42387&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5649178	252623088							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77773	C=CC(=O)N1CCn2nc(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c(O)c1)CC3	InChI=1S/C21H22ClN5O3/c1-3-29-20(28)26-9-7-21(8-10-26)16(12-23)18(24)30-19-17(21)13(2)25-27(19)15-6-4-5-14(22)11-15/h4-6,11,16,24H,3,7-10H2,1-2H3	UCLBLMBJMLGDCA-UHFFFAOYSA-N	42389	1-(5-(4-bromo-3- hydroxybenzoyl)-2-(4- isopropylphenyl)- 4,5,5a,6,8,9-hexahydro- 1,5,7,9a- tetraazabenzo[cd]azulen- 7(3H)-yl)prop-2-en-1- one::US20250346600, Compound 37	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42389&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896534	252623090							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77774	C=CC(=O)N1CCc2nc(-c3ccc(C(C)C)cc3)n3c2C(C1)N(C(=O)c1ccc(Br)c2nc[nH]c12)CC3	InChI=1S/C13H15NO3/c1-8-3-9(2)5-11(4-8)14-7-10(13(16)17)6-12(14)15/h3-5,10H,6-7H2,1-2H3,(H,16,17)	ZVYUEYJQRCOJDI-UHFFFAOYSA-N	42390	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 4,5,5a,6,8,9-hexahydro- 1,2a,5,7- tetraazabenzo[cd]azulen- 7(3H)-yl)prop-2-en-1- one::US20250346600, Compound 38	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42390&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2741834	252623091							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77775	C=CC(=O)N1CCc2nc(-c3ccc(C(C)C)cc3)n3c2C(C1)N(C(=O)c1ccc(Br)c2nc[nH]c12)CC3	InChI=1S/C13H15NO3/c1-8-3-9(2)5-11(4-8)14-7-10(13(16)17)6-12(14)15/h3-5,10H,6-7H2,1-2H3,(H,16,17)	ZVYUEYJQRCOJDI-UHFFFAOYSA-N	42390	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 4,5,5a,6,8,9-hexahydro- 1,2a,5,7- tetraazabenzo[cd]azulen- 7(3H)-yl)prop-2-en-1- one::US20250346600, Compound 38	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42390&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2741834	252623091							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77776	C=CC(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C20H26ClN5O2S/c1-2-26-17(11-12-22-19(28)14-7-9-15(21)10-8-14)24-25-20(26)29-13-18(27)23-16-5-3-4-6-16/h7-10,16H,2-6,11-13H2,1H3,(H,22,28)(H,23,27)	RYVQRYUXUQZUPT-UHFFFAOYSA-N	42391	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 39	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42391&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2959770	252623092							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77777	C=CC(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C20H26ClN5O2S/c1-2-26-17(11-12-22-19(28)14-7-9-15(21)10-8-14)24-25-20(26)29-13-18(27)23-16-5-3-4-6-16/h7-10,16H,2-6,11-13H2,1H3,(H,22,28)(H,23,27)	RYVQRYUXUQZUPT-UHFFFAOYSA-N	42391	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 39	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42391&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2959770	252623092							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77778	C=CC(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)C1=CC2=NN=C(Br)C2=CC1)CC3	InChI=1S/C15H11NO3S/c1-19-15(18)11-9-16(12-6-3-2-5-10(11)12)14(17)13-7-4-8-20-13/h2-9H,1H3	MUEWTXJMZDEHDX-UHFFFAOYSA-N	42392	1-(5-(3-bromo-1H- indazole-6-carbonyl)-2- (4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 40	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42392&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			702931	252623093							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77779	C=CC(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)C1=CC2=NN=C(Br)C2=CC1)CC3	InChI=1S/C15H11NO3S/c1-19-15(18)11-9-16(12-6-3-2-5-10(11)12)14(17)13-7-4-8-20-13/h2-9H,1H3	MUEWTXJMZDEHDX-UHFFFAOYSA-N	42392	1-(5-(3-bromo-1H- indazole-6-carbonyl)-2- (4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 40	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42392&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			702931	252623093							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77780	C=CC(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C12H15NO3S/c1-9(15)10-2-4-11(5-3-10)13-12(16)8-17-7-6-14/h2-5,14H,6-8H2,1H3,(H,13,16)	PXGXPOMBCLKALX-UHFFFAOYSA-N	42393	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 41	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42393&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2190575	252623094							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77781	C=CC(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C12H15NO3S/c1-9(15)10-2-4-11(5-3-10)13-12(16)8-17-7-6-14/h2-5,14H,6-8H2,1H3,(H,13,16)	PXGXPOMBCLKALX-UHFFFAOYSA-N	42393	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 41	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42393	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42393&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2190575	252623094							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77782	C=CC(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2n[nH]cc12)CC3	InChI=1S/C17H21NO5/c1-6-22-17(20)15-10(2)18(4)14-8-7-12(9-13(14)15)23-11(3)16(19)21-5/h7-9,11H,6H2,1-5H3	XRVSJLSOULINGX-UHFFFAOYSA-N	42394	1-(5-(7-bromo-1H- indazole-4-carbonyl)-2- (4-cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd] inden-7-yl)prop-2-en-1-one::US20250346600, Compound 42	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42394&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2892134	252623095							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77783	C=CC(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2n[nH]cc12)CC3	InChI=1S/C17H21NO5/c1-6-22-17(20)15-10(2)18(4)14-8-7-12(9-13(14)15)23-11(3)16(19)21-5/h7-9,11H,6H2,1-5H3	XRVSJLSOULINGX-UHFFFAOYSA-N	42394	1-(5-(7-bromo-1H- indazole-4-carbonyl)-2- (4-cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd] inden-7-yl)prop-2-en-1-one::US20250346600, Compound 42	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42394	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42394&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2892134	252623095							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77784	C=CC(=O)N1CCOc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C22H25N5O2S/c1-26-20(15-17-7-3-2-4-8-17)24-25-22(26)30-16-21(28)23-18-9-5-6-10-19(18)27-11-13-29-14-12-27/h2-10H,11-16H2,1H3,(H,23,28)	PUFRVAXJGCICDW-UHFFFAOYSA-N	42395	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)-5-(7-bromo- 1H-benzo[d]imidazole- 4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 43	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42395&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1088664	252623096							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77785	C=CC(=O)N1CCOc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C22H25N5O2S/c1-26-20(15-17-7-3-2-4-8-17)24-25-22(26)30-16-21(28)23-18-9-5-6-10-19(18)27-11-13-29-14-12-27/h2-10H,11-16H2,1H3,(H,23,28)	PUFRVAXJGCICDW-UHFFFAOYSA-N	42395	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)-5-(7-bromo- 1H-benzo[d]imidazole- 4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 43	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42395	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42395&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1088664	252623096							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77786	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C19H24FN3O5S2/c1-4-22(5-2)30(27,28)18-11-9-16(10-12-18)21-19(24)14-23(29(3,25)26)17-8-6-7-15(20)13-17/h6-13H,4-5,14H2,1-3H3,(H,21,24)	NXUPZMKZPIKYFD-UHFFFAOYSA-N	42396	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 44	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42396&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1295669	252623097							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77787	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C19H24FN3O5S2/c1-4-22(5-2)30(27,28)18-11-9-16(10-12-18)21-19(24)14-23(29(3,25)26)17-8-6-7-15(20)13-17/h6-13H,4-5,14H2,1-3H3,(H,21,24)	NXUPZMKZPIKYFD-UHFFFAOYSA-N	42396	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 44	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42396	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42396&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1295669	252623097							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77788	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C19H17NO4/c1-13-14(12-23-17-5-3-2-4-6-17)11-18(24-13)19(22)20-15-7-9-16(21)10-8-15/h2-11,21H,12H2,1H3,(H,20,22)	ZJFWEPODJBPURP-UHFFFAOYSA-N	42397	1-(2-(2-hydroxy-4- isopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 45	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42397&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			877453	252623098							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77789	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C19H17NO4/c1-13-14(12-23-17-5-3-2-4-6-17)11-18(24-13)19(22)20-15-7-9-16(21)10-8-15/h2-11,21H,12H2,1H3,(H,20,22)	ZJFWEPODJBPURP-UHFFFAOYSA-N	42397	1-(2-(2-hydroxy-4- isopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 45	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42397	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42397&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			877453	252623098							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77790	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H21N3O4S/c19-15(12-16-8-10-22-11-9-16)17-6-7-18(13-17)23(20,21)14-4-2-1-3-5-14/h1-5H,6-13H2	QAXBAVPFXQUSCT-UHFFFAOYSA-N	42398	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 46	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42398&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			747981	252623099							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77791	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C15H21N3O4S/c19-15(12-16-8-10-22-11-9-16)17-6-7-18(13-17)23(20,21)14-4-2-1-3-5-14/h1-5H,6-13H2	QAXBAVPFXQUSCT-UHFFFAOYSA-N	42398	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 46	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42398	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42398&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			747981	252623099							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77792	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C13H16N2OS/c1-3-4-9-17-13-15-14-12(16-13)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3	JPAWHIGGTVOTJC-UHFFFAOYSA-N	42399	1-(5-(5-hydroxy-6- (trifluoromethyl)nicotinoyl)- 2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 47	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42399&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2188596	252623100							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77793	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C13H16N2OS/c1-3-4-9-17-13-15-14-12(16-13)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3	JPAWHIGGTVOTJC-UHFFFAOYSA-N	42399	1-(5-(5-hydroxy-6- (trifluoromethyl)nicotinoyl)- 2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 47	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42399&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2188596	252623100							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77794	C=CC(=O)N1CCOc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c(O)c1)CC3	InChI=1S/C14H14F3N3O2S/c1-18-13-20(2)12(22)10(23-13)7-11(21)19-9-5-3-4-8(6-9)14(15,16)17/h3-6,10H,7H2,1-2H3,(H,19,21)	RQNSMEBTBJWQAR-UHFFFAOYSA-N	42400	1-(5-(4-bromo-3- hydroxybenzoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 48	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42400	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42400&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2939431	252623101							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77795	C=CC(=O)N1CCOc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C21H18N4O6S/c1-13-12-18(23-31-13)24-32(29,30)15-8-6-14(7-9-15)22-19(26)10-11-25-20(27)16-4-2-3-5-17(16)21(25)28/h2-9,12H,10-11H2,1H3,(H,22,26)(H,23,24)	LIQPVKLDLTXVJS-UHFFFAOYSA-N	42401	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 49	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42401&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2213836	252623102							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77796	C=CC(=O)N1CCOc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C21H18N4O6S/c1-13-12-18(23-31-13)24-32(29,30)15-8-6-14(7-9-15)22-19(26)10-11-25-20(27)16-4-2-3-5-17(16)21(25)28/h2-9,12H,10-11H2,1H3,(H,22,26)(H,23,24)	LIQPVKLDLTXVJS-UHFFFAOYSA-N	42401	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 49	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42401	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42401&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2213836	252623102							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77797	C=CC(=O)N1CCOc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2[nH]ncc12)CC3	InChI=1S/C17H18N2O/c1-11-2-3-15-14(10-11)17-13(6-9-20-17)16(19-15)12-4-7-18-8-5-12/h2-5,7-8,10,13,16-17,19H,6,9H2,1H3	YZFLWQYXBOQANK-UHFFFAOYSA-N	42402	1-(2-(4- cyclopropylphenyl)-5-(7- (trifluoromethyl)-1H- indazole-4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 50	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42402&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5308449	252623103							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77798	C=CC(=O)N1CCOc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2[nH]ncc12)CC3	InChI=1S/C17H18N2O/c1-11-2-3-15-14(10-11)17-13(6-9-20-17)16(19-15)12-4-7-18-8-5-12/h2-5,7-8,10,13,16-17,19H,6,9H2,1H3	YZFLWQYXBOQANK-UHFFFAOYSA-N	42402	1-(2-(4- cyclopropylphenyl)-5-(7- (trifluoromethyl)-1H- indazole-4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 50	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42402	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42402&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5308449	252623103							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77799	CN(C)C/C=C/C(=O)N1CCOc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C11H9NOS3/c1-2-4-15-11-12-9(10(13)16-11)6-8-3-5-14-7-8/h2-3,5-7H,1,4H2	SZTGXTIRCQBOKL-UHFFFAOYSA-N	42403	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)-4- (dimethylamino)but-2- en-1-one::US20250346600, Compound 51	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42403	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42403&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2299642	252623104							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77800	C=CC(=O)N1CC(C)Oc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C22H26N2O4/c1-15-5-4-6-18(13-15)23-21(25)16-9-11-24(12-10-16)22(26)17-7-8-19(27-2)20(14-17)28-3/h4-8,13-14,16H,9-12H2,1-3H3,(H,23,25)	DFMCOYJIVZURGA-UHFFFAOYSA-N	42404	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 52	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42404&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1327311	252623105							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77801	C=CC(=O)N1CC(C)Oc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C22H26N2O4/c1-15-5-4-6-18(13-15)23-21(25)16-9-11-24(12-10-16)22(26)17-7-8-19(27-2)20(14-17)28-3/h4-8,13-14,16H,9-12H2,1-3H3,(H,23,25)	DFMCOYJIVZURGA-UHFFFAOYSA-N	42404	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 52	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42404	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42404&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1327311	252623105							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77802	C=CC(=O)N1CC(C)Oc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C16H13N3O2/c1-21-16(20)14-11-19(13-7-3-2-4-8-13)18-15(14)12-6-5-9-17-10-12/h2-11H,1H3	FHRFYYRLSIONME-UHFFFAOYSA-N	42406	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 53	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42406&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			752167	252623107							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77803	C=CC(=O)N1CC(C)Oc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C16H13N3O2/c1-21-16(20)14-11-19(13-7-3-2-4-8-13)18-15(14)12-6-5-9-17-10-12/h2-11H,1H3	FHRFYYRLSIONME-UHFFFAOYSA-N	42406	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 53	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42406	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42406&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			752167	252623107							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77804	C=CC(=O)N1CC(F)Oc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C26H34N6O3/c1-33-21-13-11-19(12-14-21)30-15-17-31(18-16-30)24(22-9-6-10-23(34-2)25(22)35-3)26-27-28-29-32(26)20-7-4-5-8-20/h6,9-14,20,24H,4-5,7-8,15-18H2,1-3H3	WENHBUMRGCQHJF-UHFFFAOYSA-N	42407	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-9-fluoro-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 54	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42407&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			645108	252623108							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77805	C=CC(=O)N1CC(F)Oc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C26H34N6O3/c1-33-21-13-11-19(12-14-21)30-15-17-31(18-16-30)24(22-9-6-10-23(34-2)25(22)35-3)26-27-28-29-32(26)20-7-4-5-8-20/h6,9-14,20,24H,4-5,7-8,15-18H2,1-3H3	WENHBUMRGCQHJF-UHFFFAOYSA-N	42407	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-9-fluoro-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 54	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42407&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			645108	252623108							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77806	C=CC(=O)N1CC(F)Oc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C26H26N6O3/c1-18-9-10-23-20(12-18)13-21(26(33)27-23)15-31(14-19-6-3-4-8-24(19)34-2)17-25-28-29-30-32(25)16-22-7-5-11-35-22/h3-13H,14-17H2,1-2H3,(H,27,33)	BMDSAZDIDMDPRU-UHFFFAOYSA-N	42408	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-9-fluoro-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 55	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42408&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			647823	252623109							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77807	C=CC(=O)N1CC(F)Oc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C26H26N6O3/c1-18-9-10-23-20(12-18)13-21(26(33)27-23)15-31(14-19-6-3-4-8-24(19)34-2)17-25-28-29-30-32(25)16-22-7-5-11-35-22/h3-13H,14-17H2,1-2H3,(H,27,33)	BMDSAZDIDMDPRU-UHFFFAOYSA-N	42408	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-9-fluoro-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd]inden- 7-yl)prop-2-en-1-one::US20250346600, Compound 55	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42408	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42408&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			647823	252623109							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77808	C=CC(=O)N1CCN(C)c2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C21H31FN6/c1-16(2)15-20(21-23-24-25-28(21)17-7-3-4-8-17)27-13-11-26(12-14-27)19-10-6-5-9-18(19)22/h5-6,9-10,16-17,20H,3-4,7-8,11-15H2,1-2H3	IJJTXVLTYBRQSS-UHFFFAOYSA-N	42409	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- isopropylphenyl)-10- methyl-2,4,5,5a,6,8,9,10- octahydro-1,2,5,7,10- pentaazacycloocta[cd] inden-7(3H)-yl)prop-2-en- 1-one::US20250346600, Compound 56	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42409	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42409&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			652510	252623110							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77809	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)c(F)c3N)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C17H26N2/c1-2-3-4-5-12-19-15-10-6-8-13(15)17(18)14-9-7-11-16(14)19/h18H,2-12H2,1H3	WKLIILWHYTVQKO-UHFFFAOYSA-N	42411	1-(2-(2-amino-3-fluoro- 4-isopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 57	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42411&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			659248	252623111							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77810	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)c(F)c3N)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C17H26N2/c1-2-3-4-5-12-19-15-10-6-8-13(15)17(18)14-9-7-11-16(14)19/h18H,2-12H2,1H3	WKLIILWHYTVQKO-UHFFFAOYSA-N	42411	1-(2-(2-amino-3-fluoro- 4-isopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 57	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42411	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42411&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			659248	252623111							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77811	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c(=O)[nH]1)CC3	InChI=1S/C16H14N2O4/c1-21-11-3-2-4-12(8-11)22-15-9-17-18-16(15)13-6-5-10(19)7-14(13)20/h2-9,19-20H,1H3,(H,17,18)	ILZQDBWJWMOSJD-UHFFFAOYSA-N	42412	6-(7-acryloyl-2-(4- isopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-3- (trifluoromethyl)pyridin- 2(1H)-one::US20250346600, Compound 58	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42412&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5389780	252623112							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77812	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c(=O)[nH]1)CC3	InChI=1S/C16H14N2O4/c1-21-11-3-2-4-12(8-11)22-15-9-17-18-16(15)13-6-5-10(19)7-14(13)20/h2-9,19-20H,1H3,(H,17,18)	ILZQDBWJWMOSJD-UHFFFAOYSA-N	42412	6-(7-acryloyl-2-(4- isopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-3- (trifluoromethyl)pyridin- 2(1H)-one::US20250346600, Compound 58	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42412	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42412&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5389780	252623112							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77813	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(OCC(N)=O)c1)CC3	InChI=1S/C16H14N2O4/c1-21-11-3-5-12(6-4-11)22-15-9-17-18-16(15)13-7-2-10(19)8-14(13)20/h2-9,19-20H,1H3,(H,17,18)	KVIYGPDOJYMQLE-UHFFFAOYSA-N	42413	2-((5-(7-acryloyl-2-(4- isopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-2- (trifluoromethyl)pyridin- 3-yl)oxy)acetamide::US20250346600, Compound 59	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42413&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5389842	252623113							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77814	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(OCC(N)=O)c1)CC3	InChI=1S/C16H14N2O4/c1-21-11-3-5-12(6-4-11)22-15-9-17-18-16(15)13-7-2-10(19)8-14(13)20/h2-9,19-20H,1H3,(H,17,18)	KVIYGPDOJYMQLE-UHFFFAOYSA-N	42413	2-((5-(7-acryloyl-2-(4- isopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-2- (trifluoromethyl)pyridin- 3-yl)oxy)acetamide::US20250346600, Compound 59	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42413	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42413&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5389842	252623113							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77815	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(OC2CNC2)c1)CC3	InChI=1S/C17H16N2O4/c1-10-17(23-13-6-4-12(22-2)5-7-13)16(19-18-10)14-8-3-11(20)9-15(14)21/h3-9,20-21H,1-2H3,(H,18,19)	AZSKFDMVCSRCDG-UHFFFAOYSA-N	42414	1-(5-(5-(azetidin-3- yloxy)-6- (trifluoromethyl) nicotinoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 60	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42414&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5390025	252623114							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77816	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(OC2CNC2)c1)CC3	InChI=1S/C17H16N2O4/c1-10-17(23-13-6-4-12(22-2)5-7-13)16(19-18-10)14-8-3-11(20)9-15(14)21/h3-9,20-21H,1-2H3,(H,18,19)	AZSKFDMVCSRCDG-UHFFFAOYSA-N	42414	1-(5-(5-(azetidin-3- yloxy)-6- (trifluoromethyl) nicotinoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 60	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42414	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42414&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5390025	252623114							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77817	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)cc1C(N)=O)CC3	InChI=1S/C20H28N2O5S2/c1-5-21(6-2)28(23,24)19-13-9-17(10-14-19)27-18-11-15-20(16-12-18)29(25,26)22(7-3)8-4/h9-16H,5-8H2,1-4H3	NKYSCFSNEBARFK-UHFFFAOYSA-N	42416	2-(7-acryloyl-2-(4- isopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-5- bromobenzamide::US20250346600, Compound 61	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42416&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1099239	252623116							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77818	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)cc1C(N)=O)CC3	InChI=1S/C20H28N2O5S2/c1-5-21(6-2)28(23,24)19-13-9-17(10-14-19)27-18-11-15-20(16-12-18)29(25,26)22(7-3)8-4/h9-16H,5-8H2,1-4H3	NKYSCFSNEBARFK-UHFFFAOYSA-N	42416	2-(7-acryloyl-2-(4- isopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-5- bromobenzamide::US20250346600, Compound 61	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42416	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42416&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1099239	252623116							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77819	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)c(OC(F)(F)F)c1)CC3	InChI=1S/C24H25N5O4S/c30-23(27-18-4-2-1-3-5-18)22(17-8-10-25-11-9-17)29(24(31)19-13-26-34-28-19)14-16-6-7-20-21(12-16)33-15-32-20/h6-13,18,22H,1-5,14-15H2,(H,27,30)	BGSVSADZEMUBIT-UHFFFAOYSA-N	42417	1-(5-(6-bromo-5- (trifluoromethoxy) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 62	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42417&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3200707	252623117							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77820	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)c(OC(F)(F)F)c1)CC3	InChI=1S/C24H25N5O4S/c30-23(27-18-4-2-1-3-5-18)22(17-8-10-25-11-9-17)29(24(31)19-13-26-34-28-19)14-16-6-7-20-21(12-16)33-15-32-20/h6-13,18,22H,1-5,14-15H2,(H,27,30)	BGSVSADZEMUBIT-UHFFFAOYSA-N	42417	1-(5-(6-bromo-5- (trifluoromethoxy) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 62	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42417	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42417&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3200707	252623117							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77821	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3OC)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C25H26F3N5O/c1-24(2,3)33-23(29-30-31-33)22(19-11-13-20(14-12-19)25(26,27)28)32(17-21-10-7-15-34-21)16-18-8-5-4-6-9-18/h4-15,22H,16-17H2,1-3H3	GJCKFQOJOGUGHY-UHFFFAOYSA-N	42418	1-(2-(4-cyclopropyl-3- fluoro-2- methoxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 63	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42418&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3229320	252623118							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77822	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3OC)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C25H26F3N5O/c1-24(2,3)33-23(29-30-31-33)22(19-11-13-20(14-12-19)25(26,27)28)32(17-21-10-7-15-34-21)16-18-8-5-4-6-9-18/h4-15,22H,16-17H2,1-3H3	GJCKFQOJOGUGHY-UHFFFAOYSA-N	42418	1-(2-(4-cyclopropyl-3- fluoro-2- methoxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 63	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42418	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42418&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3229320	252623118							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77823	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C19H15NO2/c21-19(22)15-11-13-18(14-12-15)20(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-14H,(H,21,22)	XUDQSFMBCQRHAX-UHFFFAOYSA-N	42419	1-(2-(3-fluoro-2- hydroxy-4- isopropylphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 64	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42419	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42419&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			826220	252623119							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77824	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1CCO2)CC3	InChI=1S/C19H12Cl2F4N2O2/c1-10-17(29-9-12-13(20)3-2-4-15(12)22)16(28)5-6-27(10)18-14(21)7-11(8-26-18)19(23,24)25/h2-8H,9H2,1H3	MQXBEGVGQLPUGF-UHFFFAOYSA-N	42420	1-(5-(7-bromo-2,3- dihydrobenzofuran-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 65	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42420&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1490113	252623120							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77825	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1CCO2)CC3	InChI=1S/C19H12Cl2F4N2O2/c1-10-17(29-9-12-13(20)3-2-4-15(12)22)16(28)5-6-27(10)18-14(21)7-11(8-26-18)19(23,24)25/h2-8H,9H2,1H3	MQXBEGVGQLPUGF-UHFFFAOYSA-N	42420	1-(5-(7-bromo-2,3- dihydrobenzofuran-4- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 65	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42420	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42420&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1490113	252623120							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77826	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(F)c3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C18H20ClN3O4/c1-4-25-17(23)15(18(24)26-5-2)11-20-16-10-12(3)21-22(16)14-8-6-13(19)7-9-14/h6-11,15H,4-5H2,1-3H3	NVARRWMJOCLJGV-UHFFFAOYSA-N	42421	1-(2-(4-cyclobutyl-3- fluorophenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 66	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42421&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896535	252623121							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77827	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(F)c3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C18H20ClN3O4/c1-4-25-17(23)15(18(24)26-5-2)11-20-16-10-12(3)21-22(16)14-8-6-13(19)7-9-14/h6-11,15H,4-5H2,1-3H3	NVARRWMJOCLJGV-UHFFFAOYSA-N	42421	1-(2-(4-cyclobutyl-3- fluorophenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 66	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42421	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42421&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896535	252623121							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77828	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1N)CC3	InChI=1S/C21H28N2O3S/c1-3-21(2,20(25)22-16-8-4-5-9-16)23(15-17-10-6-12-26-17)19(24)14-18-11-7-13-27-18/h6-7,10-13,16H,3-5,8-9,14-15H2,1-2H3,(H,22,25)	HLOBYLGUYYVXFV-UHFFFAOYSA-N	42422	1-(5-(2-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 67	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42422&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3249852	252623122							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77829	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1N)CC3	InChI=1S/C21H28N2O3S/c1-3-21(2,20(25)22-16-8-4-5-9-16)23(15-17-10-6-12-26-17)19(24)14-18-11-7-13-27-18/h6-7,10-13,16H,3-5,8-9,14-15H2,1-2H3,(H,22,25)	HLOBYLGUYYVXFV-UHFFFAOYSA-N	42422	1-(5-(2-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 67	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42422	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42422&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3249852	252623122							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77830	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccn(CC(F)(F)F)c(=O)c1)CC3	InChI=1S/C20H14ClNO2/c21-15-9-7-14(8-10-15)12-22-13-17(16-4-1-2-5-18(16)22)20(23)19-6-3-11-24-19/h1-11,13H,12H2	IKRFCLVDCGHBLJ-UHFFFAOYSA-N	42423	4-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-1-(2,2,2- trifluoroethyl)pyridin- 2(1H)-one::US20250346600, Compound 68	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42423&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			955150	252623123							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77831	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccn(CC(F)(F)F)c(=O)c1)CC3	InChI=1S/C20H14ClNO2/c21-15-9-7-14(8-10-15)12-22-13-17(16-4-1-2-5-18(16)22)20(23)19-6-3-11-24-19/h1-11,13H,12H2	IKRFCLVDCGHBLJ-UHFFFAOYSA-N	42423	4-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-1-(2,2,2- trifluoroethyl)pyridin- 2(1H)-one::US20250346600, Compound 68	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42423	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42423&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			955150	252623123							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77832	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(OC(F)F)nc1)CC3	InChI=1S/C22H30N2O3S/c1-3-22(2,21(26)23-17-9-5-4-6-10-17)24(16-18-11-7-13-27-18)20(25)15-19-12-8-14-28-19/h7-8,11-14,17H,3-6,9-10,15-16H2,1-2H3,(H,23,26)	MKLKKCFIJALGBZ-UHFFFAOYSA-N	42424	1-(2-(4- cyclopropylphenyl)-5-(6- (difluoromethoxy)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 69	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42424&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5140222	252623124							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77833	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(OC(F)F)nc1)CC3	InChI=1S/C22H30N2O3S/c1-3-22(2,21(26)23-17-9-5-4-6-10-17)24(16-18-11-7-13-27-18)20(25)15-19-12-8-14-28-19/h7-8,11-14,17H,3-6,9-10,15-16H2,1-2H3,(H,23,26)	MKLKKCFIJALGBZ-UHFFFAOYSA-N	42424	1-(2-(4- cyclopropylphenyl)-5-(6- (difluoromethoxy)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 69	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42424	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42424&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5140222	252623124							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77834	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc2c(c1)[nH]c(=O)n2C)CC3	InChI=1S/C19H22N2O5S/c1-11-5-6-12(2)15(8-11)27-10-14-16(19(23)24)17(26-21-14)18(22)20-9-13-4-3-7-25-13/h5-6,8,13H,3-4,7,9-10H2,1-2H3,(H,20,22)(H,23,24)	KYEAKVQAEYTNDI-UHFFFAOYSA-N	42427	5-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-1-methyl- 1,3-dihydro-2H- benzo[d]imidazol-2-one::US20250346600, Compound 70	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42427&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			11958496	252623127							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77835	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc2c(c1)[nH]c(=O)n2C)CC3	InChI=1S/C19H22N2O5S/c1-11-5-6-12(2)15(8-11)27-10-14-16(19(23)24)17(26-21-14)18(22)20-9-13-4-3-7-25-13/h5-6,8,13H,3-4,7,9-10H2,1-2H3,(H,20,22)(H,23,24)	KYEAKVQAEYTNDI-UHFFFAOYSA-N	42427	5-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-1-methyl- 1,3-dihydro-2H- benzo[d]imidazol-2-one::US20250346600, Compound 70	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42427	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42427&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			11958496	252623127							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77836	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(F)c3N)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C16H17ClN2O4S/c1-2-3-8-18-15(20)14-13(16(21)22)12(19-23-14)9-24-11-6-4-10(17)5-7-11/h4-7H,2-3,8-9H2,1H3,(H,18,20)(H,21,22)	GVCDGCCXYOZNCQ-UHFFFAOYSA-N	42428	1-(2-(2-amino-4- cyclobutyl-3- fluorophenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 71	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42428	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42428&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			11958550	252623128							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77837	C=CC(=O)N1CC(OC)c2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C23H25N2O/c1-18-11-13-20(14-12-18)22(26)17-24-16-21(19-8-4-2-5-9-19)25-15-7-3-6-10-23(24)25/h2,4-5,8-9,11-14,16H,3,6-7,10,15,17H2,1H3/q+1	VIRLFYAIXYKOCM-UHFFFAOYSA-N	42429	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)-9- methoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 72	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42429&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			876519	252623129							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77838	C=CC(=O)N1CC(OC)c2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C23H25N2O/c1-18-11-13-20(14-12-18)22(26)17-24-16-21(19-8-4-2-5-9-19)25-15-7-3-6-10-23(24)25/h2,4-5,8-9,11-14,16H,3,6-7,10,15,17H2,1H3/q+1	VIRLFYAIXYKOCM-UHFFFAOYSA-N	42429	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)-9- methoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 72	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42429	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42429&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			876519	252623129							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77839	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2ncn(CCOC)c12)CC3	InChI=1S/C24H35N3O6S/c1-18(2)14-25(15-19(3)4)16-21(28)17-26(34(31,32)22-9-7-6-8-10-22)23-13-20(27(29)30)11-12-24(23)33-5/h6-13,18-19,21,28H,14-17H2,1-5H3	SZICYTQLNSXHIM-UHFFFAOYSA-N	42430	1-(5-(4-bromo-1-(2- methoxyethyl)-1H- benzo[d]imidazole-7- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 73	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42430&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2884390	252623130							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77840	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2ncn(CCOC)c12)CC3	InChI=1S/C24H35N3O6S/c1-18(2)14-25(15-19(3)4)16-21(28)17-26(34(31,32)22-9-7-6-8-10-22)23-13-20(27(29)30)11-12-24(23)33-5/h6-13,18-19,21,28H,14-17H2,1-5H3	SZICYTQLNSXHIM-UHFFFAOYSA-N	42430	1-(5-(4-bromo-1-(2- methoxyethyl)-1H- benzo[d]imidazole-7- carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 73	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42430	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42430&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2884390	252623130							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77841	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(OC(F)F)nc1)CC3	InChI=1S/C18H28N2O4/c1-4-6-13-18(23,14-7-5-2)16(21)19-20(17(22)24-3)15-11-9-8-10-12-15/h8-12,23H,4-7,13-14H2,1-3H3,(H,19,21)	ZTTHCWMHGCGJEJ-UHFFFAOYSA-N	42431	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(6- (difluoromethoxy) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 74	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42431&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1899455	252623131							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77842	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(OC(F)F)nc1)CC3	InChI=1S/C18H28N2O4/c1-4-6-13-18(23,14-7-5-2)16(21)19-20(17(22)24-3)15-11-9-8-10-12-15/h8-12,23H,4-7,13-14H2,1-3H3,(H,19,21)	ZTTHCWMHGCGJEJ-UHFFFAOYSA-N	42431	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(6- (difluoromethoxy) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 74	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42431	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42431&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1899455	252623131							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77843	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2[nH]c(CO)nc12)CC3	InChI=1S/C22H24N2O3S2/c1-3-16-12-8-13-17(4-2)20(16)23-22(25)21(18-10-6-5-7-11-18)24-29(26,27)19-14-9-15-28-19/h5-15,21,24H,3-4H2,1-2H3,(H,23,25)	AYDCGXFUTQPEON-UHFFFAOYSA-N	42432	1-(5-(7-bromo-2- (hydroxymethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 75	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42432&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			12005500	252623132							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77844	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2[nH]c(CO)nc12)CC3	InChI=1S/C22H24N2O3S2/c1-3-16-12-8-13-17(4-2)20(16)23-22(25)21(18-10-6-5-7-11-18)24-29(26,27)19-14-9-15-28-19/h5-15,21,24H,3-4H2,1-2H3,(H,23,25)	AYDCGXFUTQPEON-UHFFFAOYSA-N	42432	1-(5-(7-bromo-2- (hydroxymethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 75	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42432	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42432&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			12005500	252623132							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77845	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1N)CC3	InChI=1S/C20H21NO3/c1-20(2,3)21-19(22)18-16(13-23-14-9-5-4-6-10-14)15-11-7-8-12-17(15)24-18/h4-12H,13H2,1-3H3,(H,21,22)	GFYJFCLWQQKBHO-UHFFFAOYSA-N	42433	1-(5-(2-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 76	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42433	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42433&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2669460	252623133							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77846	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2ncn(CC4CCO4)c12)CC3	InChI=1S/C37H34F4N4O4/c1-49-35(48)36(19-23-9-12-27(38)13-10-23)32-26(22-45(36)33(46)25-7-3-2-4-8-25)17-29-28(32)18-30(34(47)43-15-5-6-16-43)44(29)21-24-11-14-31(42-20-24)37(39,40)41/h2-4,7-14,18,20,26,32H,5-6,15-17,19,21-22H2,1H3	XCKMVXFUJNWDRX-UHFFFAOYSA-N	42434	1-(5-(4-bromo-1- ((oxetan-2-yl)methyl)- 1H-benzo[d]imidazole- 7-carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 82	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42434&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3247244	242053022							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77847	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2ncn(CC4CCO4)c12)CC3	InChI=1S/C37H34F4N4O4/c1-49-35(48)36(19-23-9-12-27(38)13-10-23)32-26(22-45(36)33(46)25-7-3-2-4-8-25)17-29-28(32)18-30(34(47)43-15-5-6-16-43)44(29)21-24-11-14-31(42-20-24)37(39,40)41/h2-4,7-14,18,20,26,32H,5-6,15-17,19,21-22H2,1H3	XCKMVXFUJNWDRX-UHFFFAOYSA-N	42434	1-(5-(4-bromo-1- ((oxetan-2-yl)methyl)- 1H-benzo[d]imidazole- 7-carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 82	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42434	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42434&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3247244	242053022							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77848	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2ncn(CC4CCO4)c12)CC3	InChI=1S/C21H21F3N4OS/c1-12-16-18(28-10-6-3-7-11-28)25-13(2)26-20(16)30-17(12)19(29)27-15-9-5-4-8-14(15)21(22,23)24/h4-5,8-9H,3,6-7,10-11H2,1-2H3,(H,27,29)	CUQOPNSQEJYQLQ-UHFFFAOYSA-N	42436	1-(5-(4-bromo-1- ((oxetan-2-yl)methyl)- 1H-benzo[d]imidazole- 7-carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 83	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42436&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4557532	252623135							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77849	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2ncn(CC4CCO4)c12)CC3	InChI=1S/C21H21F3N4OS/c1-12-16-18(28-10-6-3-7-11-28)25-13(2)26-20(16)30-17(12)19(29)27-15-9-5-4-8-14(15)21(22,23)24/h4-5,8-9H,3,6-7,10-11H2,1-2H3,(H,27,29)	CUQOPNSQEJYQLQ-UHFFFAOYSA-N	42436	1-(5-(4-bromo-1- ((oxetan-2-yl)methyl)- 1H-benzo[d]imidazole- 7-carbonyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 83	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42436	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42436&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4557532	252623135							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77850	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)c(F)c3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C20H21ClN4O3/c1-13(26)19-22-24(17-9-7-16(21)8-10-17)20(25(14(2)27)23(19)3)15-5-11-18(28-4)12-6-15/h5-12,20H,1-4H3	ULDWTJZDCNMQOG-UHFFFAOYSA-N	42437	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)-3-fluorophenyl)-5-(7- bromo-1H- benzo[d]imidazole-4- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 84	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42437&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			539575	252623136							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77851	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)c(F)c3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C20H21ClN4O3/c1-13(26)19-22-24(17-9-7-16(21)8-10-17)20(25(14(2)27)23(19)3)15-5-11-18(28-4)12-6-15/h5-12,20H,1-4H3	ULDWTJZDCNMQOG-UHFFFAOYSA-N	42437	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)-3-fluorophenyl)-5-(7- bromo-1H- benzo[d]imidazole-4- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 84	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42437	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42437&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			539575	252623136							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77852	C=CC(=O)N1CCc2nc(-c3ccc(C4CCC4)cc3)n3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C21H21N2S2/c1-4-23-17-11-7-8-12-18(17)24-21(23)13-20-22(3)14-19(25-20)16-10-6-5-9-15(16)2/h5-14H,4H2,1-3H3/q+1	OKJGYJKUYOPDRF-UHFFFAOYSA-N	42438	1-(2-(4- cyclobutylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotino yl)-4,5,5a,6,8,9- hexahydro-1,2a,5,7- tetraazabenzo[cd]azulen- 7(3H)-yl)prop-2-en-1- one::US20250346600, Compound 86	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42438&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6140197	252623137							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77853	C=CC(=O)N1CCc2nc(-c3ccc(C4CCC4)cc3)n3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C21H21N2S2/c1-4-23-17-11-7-8-12-18(17)24-21(23)13-20-22(3)14-19(25-20)16-10-6-5-9-15(16)2/h5-14H,4H2,1-3H3/q+1	OKJGYJKUYOPDRF-UHFFFAOYSA-N	42438	1-(2-(4- cyclobutylphenyl)-5-(5- hydroxy-6- (trifluoromethyl)nicotino yl)-4,5,5a,6,8,9- hexahydro-1,2a,5,7- tetraazabenzo[cd]azulen- 7(3H)-yl)prop-2-en-1- one::US20250346600, Compound 86	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42438	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42438&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6140197	252623137							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77854	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2n[nH]cc12)CC3	InChI=1S/C23H24N2O4S/c1-29-20-14-12-19(13-15-20)25(23(26)18-7-3-2-4-8-18)30(27,28)21-11-5-9-17-10-6-16-24-22(17)21/h5-6,9-16,18H,2-4,7-8H2,1H3	IPIPZWUBIRRSHV-UHFFFAOYSA-N	42439	1-(5-(7-bromo-1H- indazole-4-carbonyl)-2- (4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 87	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42439&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			993437	252623138							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77855	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2n[nH]cc12)CC3	InChI=1S/C23H24N2O4S/c1-29-20-14-12-19(13-15-20)25(23(26)18-7-3-2-4-8-18)30(27,28)21-11-5-9-17-10-6-16-24-22(17)21/h5-6,9-16,18H,2-4,7-8H2,1H3	IPIPZWUBIRRSHV-UHFFFAOYSA-N	42439	1-(5-(7-bromo-1H- indazole-4-carbonyl)-2- (4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 87	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42439	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42439&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			993437	252623138							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77856	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(OC(F)F)N=2)CC3	InChI=1S/C12H18ClNO2/c1-8(2)16-12-9(7-14-3)5-10(13)6-11(12)15-4/h5-6,8,14H,7H2,1-4H3	LUMXGICJTFNECJ-UHFFFAOYSA-N	42442	1-(5-(7-bromo-2- (difluoromethoxy)-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 88	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42442&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			973094	252623141							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77857	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(SC)c1)CC3	InChI=1S/C21H30N2O/c1-15-10-11-18-16(2)13-21(3,4)23(19(18)12-15)20(24)14-22-17-8-6-5-7-9-17/h10-13,17,22H,5-9,14H2,1-4H3	SJDZSJFEYDEEBA-UHFFFAOYSA-N	42443	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(5- (methylthio)-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 89	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42443&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1460705	252623142							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77858	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(SC)c1)CC3	InChI=1S/C21H30N2O/c1-15-10-11-18-16(2)13-21(3,4)23(19(18)12-15)20(24)14-22-17-8-6-5-7-9-17/h10-13,17,22H,5-9,14H2,1-4H3	SJDZSJFEYDEEBA-UHFFFAOYSA-N	42443	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(5- (methylthio)-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 89	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42443&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1460705	252623142							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77859	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C16H24BrNO/c1-16(2,3)18-11-12-10-13(17)8-9-15(12)19-14-6-4-5-7-14/h8-10,14,18H,4-7,11H2,1-3H3	SGGCEVYDKLLYSK-UHFFFAOYSA-N	42444	1-(5-(4-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-7- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 90	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42444&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			972410	252623143							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77860	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C16H24BrNO/c1-16(2,3)18-11-12-10-13(17)8-9-15(12)19-14-6-4-5-7-14/h8-10,14,18H,4-7,11H2,1-3H3	SGGCEVYDKLLYSK-UHFFFAOYSA-N	42444	1-(5-(4-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-7- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 90	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42444&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			972410	252623143							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77861	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(O)c3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C24H32N2O4/c1-16-14-20(24(2,3)4)30-22(16)23(28)26(18-12-8-9-13-19(18)29-5)15-21(27)25-17-10-6-7-11-17/h8-9,12-14,17H,6-7,10-11,15H2,1-5H3,(H,25,27)	UMVIEUMWWMRESW-UHFFFAOYSA-N	42445	1-(2-(4-cyclobutyl-3- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 91	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42445&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1454987	252623144							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77862	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(O)c3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C24H32N2O4/c1-16-14-20(24(2,3)4)30-22(16)23(28)26(18-12-8-9-13-19(18)29-5)15-21(27)25-17-10-6-7-11-17/h8-9,12-14,17H,6-7,10-11,15H2,1-5H3,(H,25,27)	UMVIEUMWWMRESW-UHFFFAOYSA-N	42445	1-(2-(4-cyclobutyl-3- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 91	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42445&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1454987	252623144							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77863	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C19H23N5O2/c1-23-12-10-20-19(23)16-5-3-4-11-24(16)13-17-21-18(22-26-17)14-6-8-15(25-2)9-7-14/h6-10,12,16H,3-5,11,13H2,1-2H3	SHLZAWNZYJZEBD-UHFFFAOYSA-N	42446	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)-2-hydroxyphenyl)-5- (5-hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 92	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42446&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16190203	252623145							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77864	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C19H23N5O2/c1-23-12-10-20-19(23)16-5-3-4-11-24(16)13-17-21-18(22-26-17)14-6-8-15(25-2)9-7-14/h6-10,12,16H,3-5,11,13H2,1-2H3	SHLZAWNZYJZEBD-UHFFFAOYSA-N	42446	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)-2-hydroxyphenyl)-5- (5-hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 92	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42446&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16190203	252623145							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77865	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(OC(F)(F)F)nc1)CC3	InChI=1S/C24H26FN5/c1-17-4-10-23(11-5-17)30-16-21(24(28-30)20-6-8-22(25)9-7-20)15-26-12-13-29-19(3)14-18(2)27-29/h4-11,14,16,26H,12-13,15H2,1-3H3	SCKXXJKTIMSHFN-UHFFFAOYSA-N	42447	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(6- (trifluoromethoxy) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 93	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42447&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16192223	252623146							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77866	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(OC(F)(F)F)nc1)CC3	InChI=1S/C24H26FN5/c1-17-4-10-23(11-5-17)30-16-21(24(28-30)20-6-8-22(25)9-7-20)15-26-12-13-29-19(3)14-18(2)27-29/h4-11,14,16,26H,12-13,15H2,1-3H3	SCKXXJKTIMSHFN-UHFFFAOYSA-N	42447	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(6- (trifluoromethoxy) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 93	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42447	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42447&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16192223	252623146							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77867	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)c(OC(F)F)c1)CC3	InChI=1S/C22H33NO2S/c1-2-25-21(24)22(12-6-9-19-7-4-3-5-8-19)13-15-23(16-14-22)20-10-17-26-18-11-20/h3-5,7-8,20H,2,6,9-18H2,1H3	SIJWYCVGHMXNCT-UHFFFAOYSA-N	42448	1-(5-(6-bromo-5- (difluoromethoxy) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 94	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42448&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16192231	252623147							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77868	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ncc(Br)c2c1=NCN=2)CC3	InChI=1S/C21H22FN3O/c1-13-9-17-10-15(3)20(25-19(17)11-14(13)2)23-7-8-24-21(26)16-5-4-6-18(22)12-16/h4-6,9-12H,7-8H2,1-3H3,(H,23,25)(H,24,26)	DZVKSBHFEHSULL-UHFFFAOYSA-N	42449	1-(5-(7-bromo-1H- imidazo[4,5-c]pyridine- 4-carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 95	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42449&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3206677	252623148							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77869	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ncc(Br)c2c1=NCN=2)CC3	InChI=1S/C21H22FN3O/c1-13-9-17-10-15(3)20(25-19(17)11-14(13)2)23-7-8-24-21(26)16-5-4-6-18(22)12-16/h4-6,9-12H,7-8H2,1-3H3,(H,23,25)(H,24,26)	DZVKSBHFEHSULL-UHFFFAOYSA-N	42449	1-(5-(7-bromo-1H- imidazo[4,5-c]pyridine- 4-carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 95	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42449	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42449&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3206677	252623148							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77870	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1)CC3	InChI=1S/C20H28N4O2/c1-13(16-11-14-6-7-15(16)10-14)22-19(26)12-24-18-5-3-2-4-17(18)23-20(24)21-8-9-25/h2-5,13-16,25H,6-12H2,1H3,(H,21,23)(H,22,26)	IMMAGYGNFBATCG-UHFFFAOYSA-N	42453	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 96	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42453&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3983351	252623151							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77871	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1)CC3	InChI=1S/C20H28N4O2/c1-13(16-11-14-6-7-15(16)10-14)22-19(26)12-24-18-5-3-2-4-17(18)23-20(24)21-8-9-25/h2-5,13-16,25H,6-12H2,1H3,(H,21,23)(H,22,26)	IMMAGYGNFBATCG-UHFFFAOYSA-N	42453	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 96	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42453&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3983351	252623151							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77872	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2n[nH]cc12)CC3	InChI=1S/C14H14BrN3S/c15-12-5-3-11(4-6-12)13-9-19-14(17-13)16-10-18-7-1-2-8-18/h3-6,9-10H,1-2,7-8H2	SBXVPSPHKHXYDP-UHFFFAOYSA-N	42455	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(7- (trifluoromethyl)-1H- indazole-4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 97	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42455&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9660894	252623153							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77873	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2n[nH]cc12)CC3	InChI=1S/C14H14BrN3S/c15-12-5-3-11(4-6-12)13-9-19-14(17-13)16-10-18-7-1-2-8-18/h3-6,9-10H,1-2,7-8H2	SBXVPSPHKHXYDP-UHFFFAOYSA-N	42455	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(7- (trifluoromethyl)-1H- indazole-4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 97	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42455&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9660894	252623153							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77874	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(-n2cccn2)nc1)CC3	InChI=1S/C25H23N2/c1-18-12-14-22(19(2)16-18)27-24(20-8-4-3-5-9-20)17-26-23-11-7-6-10-21(23)13-15-25(26)27/h3-12,14,16-17H,13,15H2,1-2H3/q+1	FMGRGIOUUGFHJP-UHFFFAOYSA-N	42456	1-(5-(6-(1H-pyrazol-1- yl)nicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 98	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42456&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4287464	252623154							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77875	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C22H28N2O4S/c1-24(19-11-13-20(28-2)14-12-19)29(26,27)21-10-6-9-18(15-21)22(25)23-16-17-7-4-3-5-8-17/h6,9-15,17H,3-5,7-8,16H2,1-2H3,(H,23,25)	SNHFHXYCVKUGRY-UHFFFAOYSA-N	42460	1-(2-(4-cyclopropyl-3- fluoro-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 100	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42460&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2677285	252623158							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77876	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C22H28N2O4S/c1-24(19-11-13-20(28-2)14-12-19)29(26,27)21-10-6-9-18(15-21)22(25)23-16-17-7-4-3-5-8-17/h6,9-15,17H,3-5,7-8,16H2,1-2H3,(H,23,25)	SNHFHXYCVKUGRY-UHFFFAOYSA-N	42460	1-(2-(4-cyclopropyl-3- fluoro-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 100	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42460&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2677285	252623158							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
77877	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C22H28N2O4S/c1-16-7-9-18(10-8-16)23-22(25)17-5-4-6-21(15-17)29(26,27)24(2)19-11-13-20(28-3)14-12-19/h4-6,11-16,18H,7-10H2,1-3H3,(H,23,25)	XCCQZYTTXYSGOO-UHFFFAOYSA-N	42461	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)-3-fluoro-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 101	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42461&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16196679	252623159							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78243	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C22H28N2O4S/c1-16-7-9-18(10-8-16)23-22(25)17-5-4-6-21(15-17)29(26,27)24(2)19-11-13-20(28-3)14-12-19/h4-6,11-16,18H,7-10H2,1-3H3,(H,23,25)	XCCQZYTTXYSGOO-UHFFFAOYSA-N	42461	1-(2-(4- (bicyclo[1.1.1]pentan-1- yl)-3-fluoro-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 101	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42461&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16196679	252623159							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78244	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c(C(C)(C)O)c1)CC3	InChI=1S/C50H78O18/c1-24-34(55)39(67-41-36(57)38(65-26(3)53)30(22-62-41)64-25(2)52)37(58)42(63-24)68-40-35(56)29(54)21-61-43(40)66-33-13-14-46(6)31(47(33,7)23-51)12-15-49(9)32(46)11-10-27-28-20-45(4,5)16-18-50(28,44(59)60)19-17-48(27,49)8/h10,24,28-43,51,54-58H,11-23H2,1-9H3,(H,59,60)	YWTUZIXCNQDLDQ-UHFFFAOYSA-N	42462	1-(5-(4-bromo-3-(2- hydroxypropan-2- yl)benzoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 102	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42462&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16196966	242053023							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78245	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c(C(C)(C)O)c1)CC3	InChI=1S/C50H78O18/c1-24-34(55)39(67-41-36(57)38(65-26(3)53)30(22-62-41)64-25(2)52)37(58)42(63-24)68-40-35(56)29(54)21-61-43(40)66-33-13-14-46(6)31(47(33,7)23-51)12-15-49(9)32(46)11-10-27-28-20-45(4,5)16-18-50(28,44(59)60)19-17-48(27,49)8/h10,24,28-43,51,54-58H,11-23H2,1-9H3,(H,59,60)	YWTUZIXCNQDLDQ-UHFFFAOYSA-N	42462	1-(5-(4-bromo-3-(2- hydroxypropan-2- yl)benzoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 102	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42462&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16196966	242053023							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78246	C=CC(=O)N1CCOc2nn(-c3ccc(C4CC4)cc3C)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C18H17N5S/c1-12(2)13-7-9-14(10-8-13)18-20-22-23(21-18)11-17-19-15-5-3-4-6-16(15)24-17/h3-10,12H,11H2,1-2H3	HJBXRGQKQRQJET-UHFFFAOYSA-N	42464	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclopropyl-2- methylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd] inden-7-yl)prop-2-en-1-one::US20250346600, Compound 103	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42464&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			647568	252623160							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78247	C=CC(=O)N1CCOc2nn(-c3ccc(C4CC4)cc3C)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NCN=2)CC3	InChI=1S/C18H17N5S/c1-12(2)13-7-9-14(10-8-13)18-20-22-23(21-18)11-17-19-15-5-3-4-6-16(15)24-17/h3-10,12H,11H2,1-2H3	HJBXRGQKQRQJET-UHFFFAOYSA-N	42464	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclopropyl-2- methylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-10-oxa- 1,2,5,7- tetraazacycloocta[cd] inden-7-yl)prop-2-en-1-one::US20250346600, Compound 103	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42464&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			647568	252623160							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78248	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c(NCC(F)(F)F)c1)CC3	InChI=1S/C19H14ClN3O2S/c1-10-16(17(23-25-10)12-5-2-3-7-14(12)20)18(24)22-19-13(9-21)11-6-4-8-15(11)26-19/h2-3,5,7H,4,6,8H2,1H3,(H,22,24)	PPPHOQFSIXVYRL-UHFFFAOYSA-N	42465	1-(5-(4-bromo-3-((2,2,2- trifluoroethyl)amino) benzoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 104	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42465&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			649757	252623161							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78249	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c(NCC(F)(F)F)c1)CC3	InChI=1S/C19H14ClN3O2S/c1-10-16(17(23-25-10)12-5-2-3-7-14(12)20)18(24)22-19-13(9-21)11-6-4-8-15(11)26-19/h2-3,5,7H,4,6,8H2,1H3,(H,22,24)	PPPHOQFSIXVYRL-UHFFFAOYSA-N	42465	1-(5-(4-bromo-3-((2,2,2- trifluoroethyl)amino) benzoyl)-2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 104	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42465&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			649757	252623161							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78250	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c(C2=NN=CC2)c1)CC3	InChI=1S/C25H27N3O5S/c29-23(26-18-6-2-1-3-7-18)14-28(13-17-10-11-21-22(12-17)32-16-31-21)24(30)15-34-25-27-19-8-4-5-9-20(19)33-25/h4-5,8-12,18H,1-3,6-7,13-16H2,(H,26,29)	CHLRUDOYCKHJST-UHFFFAOYSA-N	42466	1-(5-(4-bromo-3-(1H- pyrazol-3-yl)benzoyl)-2- (4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 106	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42466&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			650606	252623162							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78251	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c(C2=NN=CC2)c1)CC3	InChI=1S/C25H27N3O5S/c29-23(26-18-6-2-1-3-7-18)14-28(13-17-10-11-21-22(12-17)32-16-31-21)24(30)15-34-25-27-19-8-4-5-9-20(19)33-25/h4-5,8-12,18H,1-3,6-7,13-16H2,(H,26,29)	CHLRUDOYCKHJST-UHFFFAOYSA-N	42466	1-(5-(4-bromo-3-(1H- pyrazol-3-yl)benzoyl)-2- (4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 106	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42466&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			650606	252623162							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78252	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(OC(F)(F)F)cc1)CC3	InChI=1S/C20H19N3O3/c1-13(14-7-5-4-6-8-14)22-20-16(12-21)23-19(26-20)15-9-10-17(24-2)18(11-15)25-3/h4-11,13,22H,1-3H3	JDTDMOCFMJYSRB-UHFFFAOYSA-N	42470	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(4- (trifluoromethoxy) benzoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 107	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42470&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			664816	252623166							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78253	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(OC(F)(F)F)cc1)CC3	InChI=1S/C20H19N3O3/c1-13(14-7-5-4-6-8-14)22-20-16(12-21)23-19(26-20)15-9-10-17(24-2)18(11-15)25-3/h4-11,13,22H,1-3H3	JDTDMOCFMJYSRB-UHFFFAOYSA-N	42470	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(4- (trifluoromethoxy) benzoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 107	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42470&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			664816	252623166							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78480	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)nn1)CC3	InChI=1S/C17H19N3O/c1-11-7-9-20(10-8-11)17-16-15(18-12(2)19-17)13-5-3-4-6-14(13)21-16/h3-6,11H,7-10H2,1-2H3	AEUVACXSTSXSIX-UHFFFAOYSA-N	42471	1-(5-(6- bromopyridazine-3- carbonyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 108	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42471&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			664856	252623167							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78481	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1O)CC3	InChI=1S/C21H33NO4/c1-15(2)13-24-18-9-7-16(8-10-18)20(23)26-19-11-21(3,4)25-14-17(19)12-22(5)6/h7-10,15,17,19H,11-14H2,1-6H3	SSALKHAQQLSWJX-UHFFFAOYSA-N	42472	1-(2-(4- cyclopropylphenyl)-5-(2- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 109	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42472&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			665164	252623168							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78482	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1O)CC3	InChI=1S/C21H33NO4/c1-15(2)13-24-18-9-7-16(8-10-18)20(23)26-19-11-21(3,4)25-14-17(19)12-22(5)6/h7-10,15,17,19H,11-14H2,1-6H3	SSALKHAQQLSWJX-UHFFFAOYSA-N	42472	1-(2-(4- cyclopropylphenyl)-5-(2- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 109	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42472&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			665164	252623168							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78483	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc2c(C)nn(C)c2c1)CC3	InChI=1S/C16H12Cl2N6S/c17-10-5-4-8(6-11(10)18)13-7-25-16-22-21-15(24(16)23-13)14-9-2-1-3-12(9)19-20-14/h4-6H,1-3,7H2,(H,19,20)	AKVGDCSDHQWUBP-UHFFFAOYSA-N	42473	1-(2-(4- cyclopropylphenyl)-5- (1,3-dimethyl-1H- pyrazolo[4,3-b]pyridine- 6-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 110	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42473&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			665910	252623169							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78484	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc2c(C)nn(C)c2c1)CC3	InChI=1S/C16H12Cl2N6S/c17-10-5-4-8(6-11(10)18)13-7-25-16-22-21-15(24(16)23-13)14-9-2-1-3-12(9)19-20-14/h4-6H,1-3,7H2,(H,19,20)	AKVGDCSDHQWUBP-UHFFFAOYSA-N	42473	1-(2-(4- cyclopropylphenyl)-5- (1,3-dimethyl-1H- pyrazolo[4,3-b]pyridine- 6-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 110	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42473&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			665910	252623169							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78485	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc2c(c1)c(C(F)(F)F)nn2C)CC3	InChI=1S/C18H18N2O4S2/c1-20-16(21)14-11-5-3-4-6-13(11)26-15(14)19-18(20)25-9-10-7-8-12(24-10)17(22)23-2/h7-8H,3-6,9H2,1-2H3	DDXJIWNRUUDOEA-UHFFFAOYSA-N	42474	1-(2-(4- cyclopropylphenyl)-5-(1- methyl-3- (trifluoromethyl)-1H- pyrazolo[3,4-b]pyridine- 5-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 111	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42474&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2577652	252623170							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78486	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(C#N)c1)CC3	InChI=1S/C15H10ClN5S/c16-11-7-5-10(6-8-11)15-18-20-21(19-15)9-14-17-12-3-1-2-4-13(12)22-14/h1-8H,9H2	OKWVBGQZABLBME-UHFFFAOYSA-N	42475	5-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-2- (trifluoromethyl)nicotino nitrile::US20250346600, Compound 112	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42475&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			860841	252623171							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78487	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(C#N)c1)CC3	InChI=1S/C15H10ClN5S/c16-11-7-5-10(6-8-11)15-18-20-21(19-15)9-14-17-12-3-1-2-4-13(12)22-14/h1-8H,9H2	OKWVBGQZABLBME-UHFFFAOYSA-N	42475	5-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-2- (trifluoromethyl)nicotino nitrile::US20250346600, Compound 112	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42475&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			860841	252623171							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78488	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Br)cc1C)CC3	InChI=1S/C16H11N3OS3/c1-2-5-11(6-3-1)15-17-12(9-22-15)10-23-16-19-18-14(20-16)13-7-4-8-21-13/h1-9H,10H2	KMFIACHVJUAGQB-UHFFFAOYSA-N	42476	1-(5-(6-bromo-4- methylnicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 113	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42476&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2085549	252623172							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78489	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)nc1C)CC3	InChI=1S/C23H17N3O5/c1-29-16-9-7-15(8-10-16)26-23(28)18-5-3-2-4-17(18)21(25-26)22(27)24-14-6-11-19-20(12-14)31-13-30-19/h2-12H,13H2,1H3,(H,24,27)	YHSSUFBBTYGHMU-UHFFFAOYSA-N	42477	1-(5-(6-bromo-2- methylnicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 114	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42477&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3235942	252623173							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78490	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)nc1C)CC3	InChI=1S/C23H17N3O5/c1-29-16-9-7-15(8-10-16)26-23(28)18-5-3-2-4-17(18)21(25-26)22(27)24-14-6-11-19-20(12-14)31-13-30-19/h2-12H,13H2,1H3,(H,24,27)	YHSSUFBBTYGHMU-UHFFFAOYSA-N	42477	1-(5-(6-bromo-2- methylnicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 114	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42477&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3235942	252623173							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78491	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nn1)CC3	InChI=1S/C17H13NO4S/c19-13(11-5-6-15-16(9-11)21-8-7-20-15)10-23-17-18-12-3-1-2-4-14(12)22-17/h1-6,9H,7-8,10H2	PJCMAJHHEQSHDR-UHFFFAOYSA-N	42479	1-(2-(4- cyclopropylphenyl)-5-(6- (trifluoromethyl) pyridazine- 3-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 115	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42479&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2948077	252623175							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78492	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cc2n(n1)CCN(C)S2(=O)=O)CC3	InChI=1S/C17H18ClN3O2/c18-13-5-7-14(8-6-13)22-12-16-20-15(11-19)17(23-16)21-9-3-1-2-4-10-21/h5-8H,1-4,9-10,12H2	MBTODARTXFFENS-UHFFFAOYSA-N	42480	1-(2-(4- cyclopropylphenyl)-5-(2- methyl-1,1-dioxido-3,4- dihydro-2H- pyrazolo[1,5- e][1,2,5]thiadiazine-7- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 116	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42480&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			714054	252623176							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78493	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)nc1N)CC3	InChI=1S/C17H15ClN2O3/c1-11-9-14(7-8-15(11)18)22-10-16-19-17(20-23-16)12-3-5-13(21-2)6-4-12/h3-9H,10H2,1-2H3	KZBRCQVQYZVOAM-UHFFFAOYSA-N	42481	1-(5-(2-amino-6- bromonicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 117	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42481&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			831603	252623177							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78494	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)nc1N)CC3	InChI=1S/C17H15ClN2O3/c1-11-9-14(7-8-15(11)18)22-10-16-19-17(20-23-16)12-3-5-13(21-2)6-4-12/h3-9H,10H2,1-2H3	KZBRCQVQYZVOAM-UHFFFAOYSA-N	42481	1-(5-(2-amino-6- bromonicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 117	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42481&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			831603	252623177							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78495	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(OCC(F)(F)F)nc1)CC3	InChI=1S/C16H15BrN2O2S/c1-11-3-2-4-12(9-11)10-22-16-18-7-8-19(16)15(20)13-5-6-14(17)21-13/h2-6,9H,7-8,10H2,1H3	FWGXAIFIZCHPCH-UHFFFAOYSA-N	42482	1-(2-(4- cyclopropylphenyl)-5-(6- (2,2,2- trifluoroethoxy)nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 118	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42482&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3361119	252623178							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78496	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C2(C#N)CC2)nc1)CC3	InChI=1S/C20H15N5O3S/c1-11(24-18(26)14-5-3-4-6-15(14)19(24)27)17-23-25-16(21-22-20(25)29-17)12-7-9-13(28-2)10-8-12/h3-11H,1-2H3	ABAGTJARVQFMJH-UHFFFAOYSA-N	42483	1-(5-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)pyridin-2- yl)cyclopropane-1- carbonitrile::US20250346600, Compound 119	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42483&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4246341	252623179							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78497	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc([N+](=O)[O-])c(O)c1)CC3	InChI=1S/C24H28N2O3/c1-18-6-3-4-7-22(18)26-13-11-25(12-14-26)10-5-15-28-20-8-9-21-19(2)16-24(27)29-23(21)17-20/h3-4,6-9,16-17H,5,10-15H2,1-2H3	PSQHWAJTQCRLGJ-UHFFFAOYSA-N	42485	1-(2-(4- cyclopropylphenyl)-5-(5- hydroxy-6- nitronicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 120	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42485&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1820316	252623181							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78498	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)C12CC(C(F)(F)F)(C1)C2)CC3	InChI=1S/C24H30N2O3/c1-5-25(6-2)15-20(28)16-29-21-12-13-23-22(14-21)24(18(4)27)17(3)26(23)19-10-8-7-9-11-19/h7-14,20,28H,5-6,15-16H2,1-4H3	XYEXGCQCDHETHC-UHFFFAOYSA-N	42486	1-(2-(4- cyclopropylphenyl)-5-(3- (trifluoromethyl)bicyclo [1.1.1]pentane-1- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 121	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42486&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2897425	252623182							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78499	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(OC(C)C)nc1)CC3	InChI=1S/C13H12N2OS/c1-3-17-13-10(8-14)6-9-7-11(16-2)4-5-12(9)15-13/h4-7H,3H2,1-2H3	NCOJTEWHCDVDKH-UHFFFAOYSA-N	42487	1-(2-(4- cyclopropylphenyl)-5-(6- isopropoxynicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 122	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42487&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			865459	252623183							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78500	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C#N)nc1)CC3	InChI=1S/C11H8N2O5S/c14-9(15)4-19-11-13-12-10(18-11)6-1-2-7-8(3-6)17-5-16-7/h1-3H,4-5H2,(H,14,15)	ANWYZYDPQJWUFS-UHFFFAOYSA-N	42488	5-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene-5- carbonyl)picolinonitrile::US20250346600, Compound 123	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42488&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1084438	252623184							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78501	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)C1=CN=C2N=C(C(F)(F)F)N=C2C1)CC3	InChI=1S/C25H25NO8S3/c1-11-9-8-10-12-13-19(24(2,3)26-15(11)12)35-16(21(28)32-5)14(20(27)31-4)25(13)36-17(22(29)33-6)18(37-25)23(30)34-7/h8-10,26H,1-7H3	UUSLHDXBBMNGHD-UHFFFAOYSA-N	42489	1-(2-(4- cyclopropylphenyl)-5-(2- (trifluoromethyl)-3H- imidazo[4,5-b]pyridine- 6-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 124	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42489&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2839884	252623185							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78502	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1csc(S(N)(=O)=O)c1)CC3	InChI=1S/C15H19ClN4OS/c16-12-6-8-14(9-7-12)21-10-11-22-15-17-18-19-20(15)13-4-2-1-3-5-13/h6-9,13H,1-5,10-11H2	MXMUCBOWNHPSIX-UHFFFAOYSA-N	42490	4-(7-acryloyl-2-(4- cyclopropylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)thiophene-2- sulfonamide::US20250346600, Compound 125	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42490&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1780041	252623186							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78503	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)F)nc1)CC3	InChI=1S/C25H20BrNO3/c26-21-13-11-18(12-14-21)17-29-23(28)16-15-22-27-24(19-7-3-1-4-8-19)25(30-22)20-9-5-2-6-10-20/h1-14H,15-17H2	GFQNWKJLSYSTGO-UHFFFAOYSA-N	42492	1-(2-(4- cyclopropylphenyl)-5-(6- (difluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 126	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42492&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2235311	252623188							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78504	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C15H18Cl2N4O2S/c1-4-22-14-18-13(21(2)3)19-15(20-14)24-8-7-23-12-6-5-10(16)9-11(12)17/h5-6,9H,4,7-8H2,1-3H3	AYTQUIGQFYRMRK-UHFFFAOYSA-N	42493	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 128	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42493&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1894428	252623189							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78505	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C15H18Cl2N4O2S/c1-4-22-14-18-13(21(2)3)19-15(20-14)24-8-7-23-12-6-5-10(16)9-11(12)17/h5-6,9H,4,7-8H2,1-3H3	AYTQUIGQFYRMRK-UHFFFAOYSA-N	42493	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 128	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42493&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1894428	252623189							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78506	C=CC(=O)N1CC(OC2CC2)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C22H21Cl2N3O2/c1-26-10-12-27(13-11-26)19-5-3-2-4-18(19)25-22(28)21-9-8-20(29-21)16-7-6-15(23)14-17(16)24/h2-9,14H,10-13H2,1H3,(H,25,28)	YHXAHURDOPRQCT-UHFFFAOYSA-N	42494	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclobutylphenyl)-9- cyclopropoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 129	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42494&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1249075	252623190							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78507	C=CC(=O)N1CC(OC2CC2)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C22H21Cl2N3O2/c1-26-10-12-27(13-11-26)19-5-3-2-4-18(19)25-22(28)21-9-8-20(29-21)16-7-6-15(23)14-17(16)24/h2-9,14H,10-13H2,1H3,(H,25,28)	YHXAHURDOPRQCT-UHFFFAOYSA-N	42494	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclobutylphenyl)-9- cyclopropoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 129	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42494	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42494&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1249075	252623190							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78508	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C22H22N2O2/c25-22(24-20-12-5-2-6-13-20)17-26-21-14-8-7-11-19(21)16-23-15-18-9-3-1-4-10-18/h1-14,23H,15-17H2,(H,24,25)	OQDSNEKQMIAGFC-UHFFFAOYSA-N	42495	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 130	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42495&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1302588	252623191							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78509	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C22H22N2O2/c25-22(24-20-12-5-2-6-13-20)17-26-21-14-8-7-11-19(21)16-23-15-18-9-3-1-4-10-18/h1-14,23H,15-17H2,(H,24,25)	OQDSNEKQMIAGFC-UHFFFAOYSA-N	42495	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 130	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42495	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42495&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1302588	252623191							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78510	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2n[nH]c(N)c12)CC3	InChI=1S/C16H18N4S2/c1-12-6-5-9-14(10-12)18-16(22)20-19-15(21)17-11-13-7-3-2-4-8-13/h2-10H,11H2,1H3,(H2,17,19,21)(H2,18,20,22)	FTNDDDBPZLMNHS-UHFFFAOYSA-N	42496	1-(5-(3-amino-7-bromo- 1H-indazole-4- carbonyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 131	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42496&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			971947	252623192							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78511	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2n[nH]c(N)c12)CC3	InChI=1S/C16H18N4S2/c1-12-6-5-9-14(10-12)18-16(22)20-19-15(21)17-11-13-7-3-2-4-8-13/h2-10H,11H2,1H3,(H2,17,19,21)(H2,18,20,22)	FTNDDDBPZLMNHS-UHFFFAOYSA-N	42496	1-(5-(3-amino-7-bromo- 1H-indazole-4- carbonyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 131	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42496	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42496&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			971947	252623192							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78512	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)cc1N)CC3	InChI=1S/C18H18N2O4S2/c1-3-24-13-6-9-15-16(10-13)25-18(19-15)20-17(21)11-26(22,23)14-7-4-12(2)5-8-14/h4-10H,3,11H2,1-2H3,(H,19,20,21)	QOUDOHCZMZWDMS-UHFFFAOYSA-N	42499	1-(5-(4-amino-6- bromonicotinoyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 132	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42499	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42499&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1248559	252623195							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78513	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C26H23ClN2O5/c1-4-34-19-10-8-18(9-11-19)29-15-22(25(30)28-17-7-5-6-16(27)12-17)20-13-23(32-2)24(33-3)14-21(20)26(29)31/h5-15H,4H2,1-3H3,(H,28,30)	FBRVUEJJXHFWTH-UHFFFAOYSA-N	42500	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 133	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42500&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5224712	252623196							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78514	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C26H23ClN2O5/c1-4-34-19-10-8-18(9-11-19)29-15-22(25(30)28-17-7-5-6-16(27)12-17)20-13-23(32-2)24(33-3)14-21(20)26(29)31/h5-15H,4H2,1-3H3,(H,28,30)	FBRVUEJJXHFWTH-UHFFFAOYSA-N	42500	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 133	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42500	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42500&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5224712	252623196							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78515	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C22H29NO2/c1-3-9-20(10-4-1)19-25-22-13-11-21(12-14-22)24-18-8-7-17-23-15-5-2-6-16-23/h1,3-4,9-14H,2,5-8,15-19H2	NUODQPIXBAZSKZ-UHFFFAOYSA-N	42503	1-(5-(4-amino-5-fluoro- 6- (trifluoromethyl)nicotino yl)-2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 134	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42503&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2297248	252623199							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78516	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C22H29NO2/c1-3-9-20(10-4-1)19-25-22-13-11-21(12-14-22)24-18-8-7-17-23-15-5-2-6-16-23/h1,3-4,9-14H,2,5-8,15-19H2	NUODQPIXBAZSKZ-UHFFFAOYSA-N	42503	1-(5-(4-amino-5-fluoro- 6- (trifluoromethyl)nicotino yl)-2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 134	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42503	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42503&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2297248	252623199							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78517	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C26H23N3O4/c1-31-19-12-9-16(10-13-19)23-22-24(28-27-23)26(30)29(18-7-5-4-6-8-18)25(22)17-11-14-20(32-2)21(15-17)33-3/h4-15,25H,1-3H3,(H,27,28)	VJDDYLRGUUCFEM-UHFFFAOYSA-N	42505	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 135	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42505&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2890146	252623201							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78518	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C26H23N3O4/c1-31-19-12-9-16(10-13-19)23-22-24(28-27-23)26(30)29(18-7-5-4-6-8-18)25(22)17-11-14-20(32-2)21(15-17)33-3/h4-15,25H,1-3H3,(H,27,28)	VJDDYLRGUUCFEM-UHFFFAOYSA-N	42505	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 135	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42505	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42505&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2890146	252623201							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78519	C=CC(=O)N1CCc2nn(-c3ccc(C(F)(F)F)nc3N)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C21H21N5O2/c27-21-17-7-3-4-8-18(17)23-20-16-6-2-1-5-15(16)19(24-26(20)21)22-9-10-25-11-13-28-14-12-25/h1-8H,9-14H2,(H,22,24)	YODBYNWPVLLQTK-UHFFFAOYSA-N	42506	1-(2-(2-amino-6- (trifluoromethyl)pyridin- 3-yl)-5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 136	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42506&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1186757	252623202							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78520	C=CC(=O)N1CCc2nn(-c3ccc(C(F)(F)F)nc3N)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C21H21N5O2/c27-21-17-7-3-4-8-18(17)23-20-16-6-2-1-5-15(16)19(24-26(20)21)22-9-10-25-11-13-28-14-12-25/h1-8H,9-14H2,(H,22,24)	YODBYNWPVLLQTK-UHFFFAOYSA-N	42506	1-(2-(2-amino-6- (trifluoromethyl)pyridin- 3-yl)-5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 136	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42506	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42506&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1186757	252623202							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78521	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)c2c1=NCN=2)CC3	InChI=1S/C20H23NO3/c1-13(2)23-19-10-8-17(9-11-19)20(22)24-21-16(5)18-7-6-14(3)15(4)12-18/h6-13H,1-5H3	XTOAXNCVFKLQHT-UHFFFAOYSA-N	42509	1-(5-(4-bromo-3H- imidazo[4,5-c]pyridine- 7-carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 137	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42509	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42509&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9563579	252623204							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78522	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C22H27N/c1-4-23(5-2)19-13-12-18-22(3,20-14-8-6-9-15-20)21-16-10-7-11-17-21/h6-11,14-17H,4-5,18-19H2,1-3H3	SMEHUBTZJNZVHX-UHFFFAOYSA-N	42512	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 138	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42512&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1896116	252623207							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78523	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C22H27N/c1-4-23(5-2)19-13-12-18-22(3,20-14-8-6-9-15-20)21-16-10-7-11-17-21/h6-11,14-17H,4-5,18-19H2,1-3H3	SMEHUBTZJNZVHX-UHFFFAOYSA-N	42512	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 138	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42512	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42512&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1896116	252623207							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78524	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C16H17FN2O4S/c1-2-3-8-18-15(20)14-13(16(21)22)11(19-23-14)9-24-12-7-5-4-6-10(12)17/h4-7H,2-3,8-9H2,1H3,(H,18,20)(H,21,22)	GVMMLMRNMLNYSB-UHFFFAOYSA-N	42514	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-3- fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 139	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42514&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			11958626	252623209							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78525	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C16H17FN2O4S/c1-2-3-8-18-15(20)14-13(16(21)22)11(19-23-14)9-24-12-7-5-4-6-10(12)17/h4-7H,2-3,8-9H2,1H3,(H,18,20)(H,21,22)	GVMMLMRNMLNYSB-UHFFFAOYSA-N	42514	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-3- fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 139	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42514	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42514&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			11958626	252623209							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78526	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Cl)c(O)c1)CC3	InChI=1S/C17H13ClN2O3/c18-15-9-5-4-8-14(15)16-10-13(20-23-16)11-22-17(21)19-12-6-2-1-3-7-12/h1-10H,11H2,(H,19,21)	UITGCCIJHSVLSQ-UHFFFAOYSA-N	42515	1-(5-(6-chloro-5- hydroxynicotinoyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 140	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42515	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42515&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1481087	252623210							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78560	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C18H14ClNOS2/c1-12-17(23-18(20-12)13-5-3-2-4-6-13)16(21)11-22-15-9-7-14(19)8-10-15/h2-10H,11H2,1H3	PHDRERHAUSRLEP-UHFFFAOYSA-N	42516	1-(2-(4-cyclobutyl-3- fluoro-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 141	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42516&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1477664	252623211							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78561	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C18H14ClNOS2/c1-12-17(23-18(20-12)13-5-3-2-4-6-13)16(21)11-22-15-9-7-14(19)8-10-15/h2-10H,11H2,1H3	PHDRERHAUSRLEP-UHFFFAOYSA-N	42516	1-(2-(4-cyclobutyl-3- fluoro-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 141	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42516	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42516&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1477664	252623211							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78562	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ncc(C(F)(F)F)cc1N)CC3	InChI=1S/C17H13ClN2OS/c18-15-9-5-4-8-14(15)12-22-17-20-19-16(21-17)11-10-13-6-2-1-3-7-13/h1-11H,12H2	NIDSYCJILKJDNL-UHFFFAOYSA-N	42517	1-(5-(3-amino-5- (trifluoromethyl) picolinoyl)-2- (4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 142	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42517&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5854588	252623212							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78563	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ncc(C(F)(F)F)cc1N)CC3	InChI=1S/C17H13ClN2OS/c18-15-9-5-4-8-14(15)12-22-17-20-19-16(21-17)11-10-13-6-2-1-3-7-13/h1-11H,12H2	NIDSYCJILKJDNL-UHFFFAOYSA-N	42517	1-(5-(3-amino-5- (trifluoromethyl) picolinoyl)-2- (4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 142	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42517	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42517&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5854588	252623212							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78564	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C19H14Cl2N2S/c20-16-8-5-12(9-17(16)21)11-24-18-10-14-7-6-13-3-1-2-4-15(13)19(14)23-22-18/h1-5,8-10H,6-7,11H2	CIFNQWVKJRAUOK-UHFFFAOYSA-N	42518	1-(5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 143	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42518&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6413289	252623213							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78565	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C19H14Cl2N2S/c20-16-8-5-12(9-17(16)21)11-24-18-10-14-7-6-13-3-1-2-4-15(13)19(14)23-22-18/h1-5,8-10H,6-7,11H2	CIFNQWVKJRAUOK-UHFFFAOYSA-N	42518	1-(5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 143	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42518	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42518&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6413289	252623213							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78566	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Cl)cc1N)CC3	InChI=1S/C24H27NO3/c1-26-22-11-7-6-10-21(22)14-15-25-17-20-12-13-23(27-2)24(16-20)28-18-19-8-4-3-5-9-19/h3-13,16,25H,14-15,17-18H2,1-2H3	UMJQMNYMVGJEGV-UHFFFAOYSA-N	42520	1-(5-(4-amino-6- chloronicotinoyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 144	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42520&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2169010	252623215							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78567	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Cl)cc1N)CC3	InChI=1S/C24H27NO3/c1-26-22-11-7-6-10-21(22)14-15-25-17-20-12-13-23(27-2)24(16-20)28-18-19-8-4-3-5-9-19/h3-13,16,25H,14-15,17-18H2,1-2H3	UMJQMNYMVGJEGV-UHFFFAOYSA-N	42520	1-(5-(4-amino-6- chloronicotinoyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 144	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42520	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42520&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2169010	252623215							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78568	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc2c(C)nn(C)c2c1)CC3	InChI=1S/C20H22ClNO4/c1-20(2,3)13-8-6-12(7-9-13)18(23)22-16-11-17(25-4)14(10-15(16)21)19(24)26-5/h6-11H,1-5H3,(H,22,23)	LFBPXCRWJWMIKV-UHFFFAOYSA-N	42521	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(1,3- dimethyl-1H- pyrazolo[4,3-b]pyridine- 6-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 145	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42521&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1183477	252623216							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78569	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc2c(C)nn(C)c2c1)CC3	InChI=1S/C20H22ClNO4/c1-20(2,3)13-8-6-12(7-9-13)18(23)22-16-11-17(25-4)14(10-15(16)21)19(24)26-5/h6-11H,1-5H3,(H,22,23)	LFBPXCRWJWMIKV-UHFFFAOYSA-N	42521	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(1,3- dimethyl-1H- pyrazolo[4,3-b]pyridine- 6-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 145	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42521	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42521&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1183477	252623216							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78570	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)F)nc1N)CC3	InChI=1S/C25H20N2O3/c1-16-6-8-17(9-7-16)22-15-20(19-4-2-3-5-21(19)27-22)25(28)26-18-10-11-23-24(14-18)30-13-12-29-23/h2-11,14-15H,12-13H2,1H3,(H,26,28)	AVBFGEPJASDZCA-UHFFFAOYSA-N	42522	1-(5-(2-amino-6- (difluoromethyl)nicotino yl)-2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 146	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42522&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1220296	252623217							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78574	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)F)nc1N)CC3	InChI=1S/C25H20N2O3/c1-16-6-8-17(9-7-16)22-15-20(19-4-2-3-5-21(19)27-22)25(28)26-18-10-11-23-24(14-18)30-13-12-29-23/h2-11,14-15H,12-13H2,1H3,(H,26,28)	AVBFGEPJASDZCA-UHFFFAOYSA-N	42522	1-(5-(2-amino-6- (difluoromethyl)nicotino yl)-2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 146	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42522	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42522&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1220296	252623217							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78575	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2[nH]nc(N)c12)CC3	InChI=1S/C21H18N2O2S2/c1-14-8-10-17(11-9-14)19(24)22-23-20(25)18(27-21(23)26)13-15(2)12-16-6-4-3-5-7-16/h3-13H,1-2H3,(H,22,24)	OALGZIWSNBLGKC-UHFFFAOYSA-N	42523	1-(5-(3-amino-7- (trifluoromethyl)-1H- indazole-4-carbonyl)-2- (4-cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 147	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42523	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42523&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2015090	252623218							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78576	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(CCO)N=2)CC3	InChI=1S/C27H23ClN2O3S/c1-18-12-13-19(2)25(16-18)30-34(32,33)26-17-21(14-15-23(26)28)27(31)29-24-11-7-6-10-22(24)20-8-4-3-5-9-20/h3-17,30H,1-2H3,(H,29,31)	ZQJTYJZLKBRKPC-UHFFFAOYSA-N	42525	1-(5-(4-bromo-2-(2- hydroxyethyl)-1H- benzo[d]imidazole-7- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 148	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42525&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2228302	252623220							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78577	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(CCO)N=2)CC3	InChI=1S/C27H23ClN2O3S/c1-18-12-13-19(2)25(16-18)30-34(32,33)26-17-21(14-15-23(26)28)27(31)29-24-11-7-6-10-22(24)20-8-4-3-5-9-20/h3-17,30H,1-2H3,(H,29,31)	ZQJTYJZLKBRKPC-UHFFFAOYSA-N	42525	1-(5-(4-bromo-2-(2- hydroxyethyl)-1H- benzo[d]imidazole-7- carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 148	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42525	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42525&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2228302	252623220							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78578	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1O)CC3	InChI=1S/C17H18N2O2S/c1-11-3-5-14(7-12(11)2)19-17(22)18-9-13-4-6-15-16(8-13)21-10-20-15/h3-8H,9-10H2,1-2H3,(H2,18,19,22)	JKNLGMFKGWOASH-UHFFFAOYSA-N	42526	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(4- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 149	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42526&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			972422	252623221							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78579	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1O)CC3	InChI=1S/C17H18N2O2S/c1-11-3-5-14(7-12(11)2)19-17(22)18-9-13-4-6-15-16(8-13)21-10-20-15/h3-8H,9-10H2,1-2H3,(H2,18,19,22)	JKNLGMFKGWOASH-UHFFFAOYSA-N	42526	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(4- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 149	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42526	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42526&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			972422	252623221							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78580	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C21H17Cl2NOS/c22-18-10-6-11-19(23)17(18)13-26-14-21(25)24-20-12-5-4-9-16(20)15-7-2-1-3-8-15/h1-12H,13-14H2,(H,24,25)	NVGDYEZKSPNREY-UHFFFAOYSA-N	42529	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 150	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42529&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2198291	252623224							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78581	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C21H17Cl2NOS/c22-18-10-6-11-19(23)17(18)13-26-14-21(25)24-20-12-5-4-9-16(20)15-7-2-1-3-8-15/h1-12H,13-14H2,(H,24,25)	NVGDYEZKSPNREY-UHFFFAOYSA-N	42529	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 150	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42529	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42529&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2198291	252623224							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78582	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c2n[nH]cc12)CC3	InChI=1S/C18H11Cl2N3S/c19-15-5-3-12(8-16(15)20)11-24-18-13(9-21)4-6-17(23-18)14-2-1-7-22-10-14/h1-8,10H,11H2	RGPKBTUJNWWAHD-UHFFFAOYSA-N	42530	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(7- (trifluoromethyl)-1H- pyrazolo[3,4-c]pyridine- 4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 151	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42530	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42530&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1543852	252623225							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78583	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1N)CC3	InChI=1S/C18H12Br2N2O3/c19-12-7-11(17(23)15(20)8-12)10-21-13-3-1-4-14(9-13)22-18(24)16-5-2-6-25-16/h1-10,23H,(H,22,24)	IFMBFHZZIVZGTG-UHFFFAOYSA-N	42531	1-(5-(2-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 152	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42531&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5447857	252623226							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78584	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C4)C5)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1N)CC3	InChI=1S/C18H12Br2N2O3/c19-12-7-11(17(23)15(20)8-12)10-21-13-3-1-4-14(9-13)22-18(24)16-5-2-6-25-16/h1-10,23H,(H,22,24)	IFMBFHZZIVZGTG-UHFFFAOYSA-N	42531	1-(5-(2-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- (bicyclo[1.1.1]pentan-1- yl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 152	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42531	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42531&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5447857	252623226							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78585	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cc(O)c2scnc2c1)CC3	InChI=1S/C18H23N3S/c1-21(2)12-7-13-22-18-15-10-6-11-16(15)19-17(20-18)14-8-4-3-5-9-14/h3-5,8-9H,6-7,10-13H2,1-2H3	AZYBPQSWPOOMFP-UHFFFAOYSA-N	42533	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(7- hydroxybenzo[d]thiazole- 5-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 153	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42533&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1998473	252623228							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78586	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cc(O)c2scnc2c1)CC3	InChI=1S/C18H23N3S/c1-21(2)12-7-13-22-18-15-10-6-11-16(15)19-17(20-18)14-8-4-3-5-9-14/h3-5,8-9H,6-7,10-13H2,1-2H3	AZYBPQSWPOOMFP-UHFFFAOYSA-N	42533	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(7- hydroxybenzo[d]thiazole- 5-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 153	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42533	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42533&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1998473	252623228							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78587	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ncc(C(F)(F)F)c2c1=NCN=2)CC3	InChI=1S/C18H19ClN2O3/c1-12-3-8-16(13(2)11-12)21-18(23)17(22)20-9-10-24-15-6-4-14(19)5-7-15/h3-8,11H,9-10H2,1-2H3,(H,20,22)(H,21,23)	SVWJCKBZAAIRLH-UHFFFAOYSA-N	42537	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(7- (trifluoromethyl)-1H- imidazo[4,5-c]pyridine- 4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 154	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42537	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42537&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2173045	252623232							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78588	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(C)(F)F)nc1N)CC3	InChI=1S/C27H24O6/c1-3-23(27(29)32-16-18-9-5-4-6-10-18)33-19-13-14-21-25(15-19)31-17-22(26(21)28)20-11-7-8-12-24(20)30-2/h4-15,17,23H,3,16H2,1-2H3	IVBLZCQYAWWDOW-UHFFFAOYSA-N	42538	1-(5-(2-amino-6-(1,1- difluoroethyl)nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 155	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42538&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2788869	252623233							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78589	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(C)(F)F)nc1N)CC3	InChI=1S/C27H24O6/c1-3-23(27(29)32-16-18-9-5-4-6-10-18)33-19-13-14-21-25(15-19)31-17-22(26(21)28)20-11-7-8-12-24(20)30-2/h4-15,17,23H,3,16H2,1-2H3	IVBLZCQYAWWDOW-UHFFFAOYSA-N	42538	1-(5-(2-amino-6-(1,1- difluoroethyl)nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 155	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42538	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42538&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2788869	252623233							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78590	C=CC(=O)N1CC(OC)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C24H30N4OS/c1-16-7-6-8-21(13-16)25-24(30)28(10-9-27(4)5)15-20-14-19-12-17(2)11-18(3)22(19)26-23(20)29/h6-8,11-14H,9-10,15H2,1-5H3,(H,25,30)(H,26,29)	ZADSNUOSVPGFAH-UHFFFAOYSA-N	42540	1-(2-(4- cyclobutylphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 9-methoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 156	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42540&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1141823	252623235							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78591	C=CC(=O)N1CC(OC)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C24H30N4OS/c1-16-7-6-8-21(13-16)25-24(30)28(10-9-27(4)5)15-20-14-19-12-17(2)11-18(3)22(19)26-23(20)29/h6-8,11-14H,9-10,15H2,1-5H3,(H,25,30)(H,26,29)	ZADSNUOSVPGFAH-UHFFFAOYSA-N	42540	1-(2-(4- cyclobutylphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 9-methoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 156	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42540	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42540&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1141823	252623235							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78592	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(SC(F)(F)F)nc1)CC3	InChI=1S/C22H27NO/c24-22(19-11-5-2-6-12-19)15-16-23(17-18-9-3-1-4-10-18)21-14-8-7-13-20(21)22/h1-6,9-12,20-21,24H,7-8,13-17H2	BIWOHGQOCMGKSL-UHFFFAOYSA-N	42541	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(6- ((trifluoromethyl)thio) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 157	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42541&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			563820	252623236							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78593	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(SC(F)(F)F)nc1)CC3	InChI=1S/C22H27NO/c24-22(19-11-5-2-6-12-19)15-16-23(17-18-9-3-1-4-10-18)21-14-8-7-13-20(21)22/h1-6,9-12,20-21,24H,7-8,13-17H2	BIWOHGQOCMGKSL-UHFFFAOYSA-N	42541	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(6- ((trifluoromethyl)thio) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 157	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42541	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42541&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			563820	252623236							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78594	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2n[nH]c(N)c12)CC3	InChI=1S/C16H13Cl3N2OS/c17-12-6-4-11(5-7-12)9-23-10-16(22)21-20-8-13-14(18)2-1-3-15(13)19/h1-8H,9-10H2,(H,21,22)	YFTSRVCVNUNVEV-UHFFFAOYSA-N	42542	1-(5-(3-amino-7-bromo- 1H-indazole-4- carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 158	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42542&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9590479	252623237							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78595	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2n[nH]c(N)c12)CC3	InChI=1S/C16H13Cl3N2OS/c17-12-6-4-11(5-7-12)9-23-10-16(22)21-20-8-13-14(18)2-1-3-15(13)19/h1-8H,9-10H2,(H,21,22)	YFTSRVCVNUNVEV-UHFFFAOYSA-N	42542	1-(5-(3-amino-7-bromo- 1H-indazole-4- carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 158	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42542	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42542&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9590479	252623237							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78596	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ncc(C(F)(F)F)c(N)n1)CC3	InChI=1S/C27H30N4O6S/c1-20(32)29-23-10-12-24(13-11-23)38(34,35)31(16-15-21-7-5-4-6-8-21)19-27(33)30-28-18-22-9-14-25(36-2)26(17-22)37-3/h4-14,17-18H,15-16,19H2,1-3H3,(H,29,32)(H,30,33)	XILHLSHWUOAQEQ-UHFFFAOYSA-N	42543	1-(5-(4-amino-5- (trifluoromethyl) pyrimidine- 2-carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 159	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42543&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9594209	252623238							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78597	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ncc(C(F)(F)F)c(N)n1)CC3	InChI=1S/C27H30N4O6S/c1-20(32)29-23-10-12-24(13-11-23)38(34,35)31(16-15-21-7-5-4-6-8-21)19-27(33)30-28-18-22-9-14-25(36-2)26(17-22)37-3/h4-14,17-18H,15-16,19H2,1-3H3,(H,29,32)(H,30,33)	XILHLSHWUOAQEQ-UHFFFAOYSA-N	42543	1-(5-(4-amino-5- (trifluoromethyl) pyrimidine- 2-carbonyl)-2-(4- cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 159	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42543	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42543&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9594209	252623238							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78598	C=CC(=O)N1CC(O)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C14H18N2O2/c1-2-3-10-18-12-6-4-11(5-7-12)13-8-9-14(17)16-15-13/h4-7H,2-3,8-10H2,1H3,(H,16,17)	UCBSDEIESXJXND-UHFFFAOYSA-N	42544	1-(5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)-9- hydroxy-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 160	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42544&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			12004848	252623239							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78599	C=CC(=O)N1CC(O)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C14H18N2O2/c1-2-3-10-18-12-6-4-11(5-7-12)13-8-9-14(17)16-15-13/h4-7H,2-3,8-10H2,1H3,(H,16,17)	UCBSDEIESXJXND-UHFFFAOYSA-N	42544	1-(5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)-9- hydroxy-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 160	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42544	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42544&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			12004848	252623239							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78600	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)nc1N)CC3	InChI=1S/C19H15BrN2O3/c20-15-9-7-14(8-10-15)13-25-18-6-2-1-5-17(18)19(23)22-21-12-16-4-3-11-24-16/h1-12H,13H2,(H,22,23)	PJIWVCXHHYRWTN-UHFFFAOYSA-N	42545	1-(5-(4-amino-2- (trifluoromethyl) pyrimidine- 5-carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 161	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42545&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			20846851	252623240							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78601	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)nc1N)CC3	InChI=1S/C19H15BrN2O3/c20-15-9-7-14(8-10-15)13-25-18-6-2-1-5-17(18)19(23)22-21-12-16-4-3-11-24-16/h1-12H,13H2,(H,22,23)	PJIWVCXHHYRWTN-UHFFFAOYSA-N	42545	1-(5-(4-amino-2- (trifluoromethyl) pyrimidine- 5-carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 161	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42545	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42545&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			20846851	252623240							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78602	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Br)cc1N)CC3	InChI=1S/C17H11Cl2FN2O/c1-9-13(7-10-6-11(20)2-5-16(10)21-9)17(23)22-12-3-4-14(18)15(19)8-12/h2-8H,1H3,(H,22,23)	IJFCDDDFCAPVGP-UHFFFAOYSA-N	42547	1-(5-(4-amino-6- chloronicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 162	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42547&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			943274	252623242							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78603	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Br)cc1N)CC3	InChI=1S/C17H11Cl2FN2O/c1-9-13(7-10-6-11(20)2-5-16(10)21-9)17(23)22-12-3-4-14(18)15(19)8-12/h2-8H,1H3,(H,22,23)	IJFCDDDFCAPVGP-UHFFFAOYSA-N	42547	1-(5-(4-amino-6- chloronicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 162	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42547	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42547&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			943274	252623242							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78604	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C26H24N2O3/c1-17(2)31-26(30)22(27-25(29)19-9-5-4-6-10-19)16-18-13-14-24-21(15-18)20-11-7-8-12-23(20)28(24)3/h4-17H,1-3H3,(H,27,29)	SDLQWKGKPVLOJF-UHFFFAOYSA-N	42548	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 163	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42548&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1915932	252623243							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78605	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C26H24N2O3/c1-17(2)31-26(30)22(27-25(29)19-9-5-4-6-10-19)16-18-13-14-24-21(15-18)20-11-7-8-12-23(20)28(24)3/h4-17H,1-3H3,(H,27,29)	SDLQWKGKPVLOJF-UHFFFAOYSA-N	42548	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 163	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42548	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42548&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1915932	252623243							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78606	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(OC(F)F)cc1N)CC3	InChI=1S/C24H10N3O3/c1-4-20(21-22(28)26(2)24(30)27(3)23(21)29)25-16-15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14H	COVOEZHJWGSFOL-UHFFFAOYSA-N	42549	1-(5-(4-amino-6- (difluoromethoxy) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 164	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42549	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42549&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5900266	252623244							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78607	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cc(F)c(C(F)(F)F)nc1N)CC3	InChI=1S/C23H20ClN3O2S/c1-29-20-4-2-3-17(13-20)21-10-7-18(14-25)23(27-21)30-15-22(28)26-12-11-16-5-8-19(24)9-6-16/h2-10,13H,11-12,15H2,1H3,(H,26,28)	QKLWDEKOCGMKJF-UHFFFAOYSA-N	42550	1-(5-(2-amino-5-fluoro- 6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 165	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42550	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42550&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1201829	252623245							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78608	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Br)cc1N)CC3	InChI=1S/C18H16Cl2N2O2S/c1-11-2-4-14(24-11)5-7-17(23)22-18-21-10-15(25-18)9-12-8-13(19)3-6-16(12)20/h2-4,6,8,10H,5,7,9H2,1H3,(H,21,22,23)	CLEYUUPWDKQMML-UHFFFAOYSA-N	42551	1-(5-(4-amino-6- bromonicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 166	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42551&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1183030	252623246							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78609	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Br)cc1N)CC3	InChI=1S/C18H16Cl2N2O2S/c1-11-2-4-14(24-11)5-7-17(23)22-18-21-10-15(25-18)9-12-8-13(19)3-6-16(12)20/h2-4,6,8,10H,5,7,9H2,1H3,(H,21,22,23)	CLEYUUPWDKQMML-UHFFFAOYSA-N	42551	1-(5-(4-amino-6- bromonicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 166	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42551	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42551&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1183030	252623246							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78610	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Cl)nc1N)CC3	InChI=1S/C22H23N3OS/c1-16-7-5-11-19(17(16)2)25-14-12-23-22(25)27-15-21(26)24-13-6-9-18-8-3-4-10-20(18)24/h3-5,7-8,10-12,14H,6,9,13,15H2,1-2H3	PNYNWXRDFAUTCI-UHFFFAOYSA-N	42553	1-(5-(2-amino-6- chloronicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 167	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42553&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4140078	252623248							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78611	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(Cl)nc1N)CC3	InChI=1S/C22H23N3OS/c1-16-7-5-11-19(17(16)2)25-14-12-23-22(25)27-15-21(26)24-13-6-9-18-8-3-4-10-20(18)24/h3-5,7-8,10-12,14H,6,9,13,15H2,1-2H3	PNYNWXRDFAUTCI-UHFFFAOYSA-N	42553	1-(5-(2-amino-6- chloronicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 167	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42553	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42553&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4140078	252623248							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78612	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1C)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C16H16ClN3S/c17-15-9-5-4-8-14(15)12-19-20-16(21)18-11-10-13-6-2-1-3-7-13/h1-9,12H,10-11H2,(H2,18,20,21)	QUKYFVRLDWWACA-UHFFFAOYSA-N	42554	1-(5-(4-amino-6- (trifluoromethyl)nicotinoyl)- 2-(4- isopropylphenyl)-6- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 168	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42554	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42554&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9566117	252623249							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78613	C=CC(=O)N1CC2c3c(nn(-c4ccc(C5CCC5)cc4)c3CCN2C(=O)c2ccc(Br)c3c2=NCN=3)C2(CC2)C1	InChI=1S/C21H22N4O3/c1-4-27-18-10-12-19(13-11-18)28-21-20(14-22-23-16(3)26)15(2)24-25(21)17-8-6-5-7-9-17/h5-14H,4H2,1-3H3,(H,23,26)	SXZZVEFPKRTJTP-UHFFFAOYSA-N	42555	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6-hexahydro- 1,2,5,7- tetraazaspiro[benzo[cd] azulene-9,1'- cyclopropan]-1(9a),2a- dien-7(8H)-yl)prop-2-en- 1-one::US20250346600, Compound 169	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42555&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6892993	252623250							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78614	C=CC(=O)N1CC2c3c(nn(-c4ccc(C5CCC5)cc4)c3CCN2C(=O)c2ccc(Br)c3c2=NCN=3)C2(CC2)C1	InChI=1S/C21H22N4O3/c1-4-27-18-10-12-19(13-11-18)28-21-20(14-22-23-16(3)26)15(2)24-25(21)17-8-6-5-7-9-17/h5-14H,4H2,1-3H3,(H,23,26)	SXZZVEFPKRTJTP-UHFFFAOYSA-N	42555	1-(5-(7-bromo-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6-hexahydro- 1,2,5,7- tetraazaspiro[benzo[cd] azulene-9,1'- cyclopropan]-1(9a),2a- dien-7(8H)-yl)prop-2-en- 1-one::US20250346600, Compound 169	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42555	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42555&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6892993	252623250							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78615	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3)c3c2C(C1)N(C(=O)C1CC1)CC3	InChI=1S/C20H16Cl2N4S/c21-17-9-4-10-18(22)16(17)12-27-20-25-24-19(26(20)23)11-14-7-3-6-13-5-1-2-8-15(13)14/h1-10H,11-12,23H2	MMTMHLFKQRYSQY-UHFFFAOYSA-N	42556	1-(5- (cyclopropanecarbonyl)- 2-(4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 170	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42556	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42556&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2376964	252623251							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78616	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3C#N)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C23H18ClNO3/c24-19-13-10-17(11-14-19)12-15-23(27)28-16-22(26)25-21-9-5-4-8-20(21)18-6-2-1-3-7-18/h1-15H,16H2,(H,25,26)	BMABHLCCGUBBJN-UHFFFAOYSA-N	42557	2-(7-acryloyl-5-(4- amino-6- (trifluoromethyl) nicotinoyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulen- 2-yl)-5- cyclobutylbenzonitrile::US20250346600, Compound 171	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42557	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42557&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2446403	252623252							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78617	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1N)CC3	InChI=1S/C19H15ClN2O4/c1-11-14(21-18(26-11)12-5-3-4-6-13(12)20)10-22-15-7-8-25-17(15)9-16(22)19(23)24-2/h3-9H,10H2,1-2H3	HRQAXGAOOLJKOG-UHFFFAOYSA-N	42558	1-(5-(2-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 172	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42558	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42558&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			15944687	252623253							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78618	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1N)CC3	InChI=1S/C17H22N2S/c18-16-11-7-3-1-2-4-9-13(11)19-17-15(16)12-8-5-6-10-14(12)20-17/h1-10H2,(H2,18,19)	SGIKZJPBBQPXKU-UHFFFAOYSA-N	42559	1-(5-(2-amino-6- (trifluoromethyl) nicotinoyl)- 2-(2-hydroxy-4- isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 173	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42559	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42559&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2330392	242053026							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78619	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C16H22N4O4/c1-2-3-4-16(21)18-17-12-13-5-6-14(15(11-13)20(22)23)19-7-9-24-10-8-19/h5-6,11-12H,2-4,7-10H2,1H3,(H,18,21)	OOEPNUKMLXNQBF-UHFFFAOYSA-N	42560	1-(5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 174	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42560&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9651051	252623254							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
78620	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)c2c1=NC(C(F)F)N=2)CC3	InChI=1S/C16H22N4O4/c1-2-3-4-16(21)18-17-12-13-5-6-14(15(11-13)20(22)23)19-7-9-24-10-8-19/h5-6,11-12H,2-4,7-10H2,1H3,(H,18,21)	OOEPNUKMLXNQBF-UHFFFAOYSA-N	42560	1-(5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(2-hydroxy- 4-isopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 174	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42560	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42560&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9651051	252623254							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79126	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(O)c1)CC3	InChI=1S/C30H34ClN3O/c31-28-13-11-24(12-14-28)23-32-17-15-27(16-18-32)30(35)34-21-19-33(20-22-34)29(25-7-3-1-4-8-25)26-9-5-2-6-10-26/h1-14,27,29H,15-23H2	GEVANJBQYBIITO-UHFFFAOYSA-N	42561	1-(2-(4-cyclopropyl-2- hydroxyphenyl)-5-(5- hydroxy-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 175	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42561	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42561&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2903812	252623255							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79127	C=CC(=O)N1CCc2nn(-c3ccc(C(C)C)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c2[nH]ncc12)CC3	InChI=1S/C26H24N2O3S/c1-3-17-10-9-11-18(4-2)24(17)28-23(29)16-31-26(30)20-13-6-5-12-19(20)25-27-21-14-7-8-15-22(21)32-25/h5-15H,3-4,16H2,1-2H3,(H,28,29)	SWMYCWBVTBITJA-UHFFFAOYSA-N	42563	1-(2-(2-hydroxy-4- isopropylphenyl)-5-(7- (trifluoromethyl)-1H- pyrazolo[3,4-c]pyridine- 4-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 176	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42563	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42563&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2385257	252623257							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79128	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(OC(F)F)cc1N)CC3	InChI=1S/C14H19BrN2OS/c1-3-4-5-6-13(18)17-14(19)16-12-8-7-11(15)9-10(12)2/h7-9H,3-6H2,1-2H3,(H2,16,17,18,19)	YNOAVDATUQSRBU-UHFFFAOYSA-N	42564	1-(5-(4-amino-6- (difluoromethoxy) nicotinoyl)- 2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 177	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42564	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42564&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1798157	252623258							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79129	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C19H24BrNO/c1-16-10-11-19(18(20)14-16)22-13-7-6-12-21(2)15-17-8-4-3-5-9-17/h3-5,8-11,14H,6-7,12-13,15H2,1-2H3	AEWAFEBQAPEWDL-UHFFFAOYSA-N	42565	1-(5-(4-amino-5-fluoro- 6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 178	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42565&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2182602	252623259							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79130	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C19H24BrNO/c1-16-10-11-19(18(20)14-16)22-13-7-6-12-21(2)15-17-8-4-3-5-9-17/h3-5,8-11,14H,6-7,12-13,15H2,1-2H3	AEWAFEBQAPEWDL-UHFFFAOYSA-N	42565	1-(5-(4-amino-5-fluoro- 6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 178	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42565	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42565&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2182602	252623259							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79131	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1NC)CC3	InChI=1S/C19H22N4O4/c1-12-4-6-15(8-13(12)2)22-18(24)11-27-16-7-5-14(9-17(16)26-3)10-21-23-19(20)25/h4-10H,11H2,1-3H3,(H,22,24)(H3,20,23,25)	REUXRILBJVRRKD-UHFFFAOYSA-N	42566	1-(2-(4- cyclopropylphenyl)-5-(4- (methylamino)-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 179	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42566	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42566&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6876206	252623260							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79132	C=CC(=O)N1CCc2nn(-c3ccc(CC(F)(F)F)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C18H18N2O2/c1-2-3-13-22-18-19-16-12-8-7-11-15(16)17(21)20(18)14-9-5-4-6-10-14/h4-12H,2-3,13H2,1H3	WPWUMAZTBQXSIV-UHFFFAOYSA-N	42567	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(2-hydroxy-4- (2,2,2- trifluoroethyl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 180	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42567	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42567&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1816029	252623261							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79133	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Cl)c(F)c1N)CC3	InChI=1S/C24H26O7/c1-7-13(3)22(26)30-20-18-16(11-9-15-10-12-17(25)29-19(15)18)28-21(20)24(5,6)31-23(27)14(4)8-2/h7-12,20-21H,1-6H3	RVGGCRQPGKFZDS-UHFFFAOYSA-N	42568	1-(5-(4-amino-6-chloro- 5-fluoronicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 181	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42568&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5281371	252623262					C09116		1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79134	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Cl)c(F)c1N)CC3	InChI=1S/C24H26O7/c1-7-13(3)22(26)30-20-18-16(11-9-15-10-12-17(25)29-19(15)18)28-21(20)24(5,6)31-23(27)14(4)8-2/h7-12,20-21H,1-6H3	RVGGCRQPGKFZDS-UHFFFAOYSA-N	42568	1-(5-(4-amino-6-chloro- 5-fluoronicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 181	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42568	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42568&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5281371	252623262					C09116		1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79135	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Br)c(F)c1N)CC3	InChI=1S/C27H21NO3/c29-26(28-25-14-8-7-13-24(25)22-11-5-2-6-12-22)19-31-27(30)23-17-15-21(16-18-23)20-9-3-1-4-10-20/h1-18H,19H2,(H,28,29)	MUGQFNDMWDZYLT-UHFFFAOYSA-N	42569	1-(5-(4-amino-6-bromo- 5-fluoronicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 182	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42569&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2450538	252623263							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79136	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(Br)c(F)c1N)CC3	InChI=1S/C27H21NO3/c29-26(28-25-14-8-7-13-24(25)22-11-5-2-6-12-22)19-31-27(30)23-17-15-21(16-18-23)20-9-3-1-4-10-20/h1-18H,19H2,(H,28,29)	MUGQFNDMWDZYLT-UHFFFAOYSA-N	42569	1-(5-(4-amino-6-bromo- 5-fluoronicotinoyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 182	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42569	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42569&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2450538	252623263							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79137	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(C)(F)F)cc1N)CC3	InChI=1S/C21H22N4O5S/c1-30-17-10-9-14(13-18(17)31(28,29)25-11-5-2-6-12-25)22-21(27)19-15-7-3-4-8-16(15)20(26)24-23-19/h3-4,7-10,13H,2,5-6,11-12H2,1H3,(H,22,27)(H,24,26)	CZXWEKRTGAVHJO-UHFFFAOYSA-N	42570	1-(5-(4-amino-6-(1,1- difluoroethyl)nicotinoyl)- 2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 183	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42570&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4876785	252623264							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79138	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(C)(F)F)cc1N)CC3	InChI=1S/C21H22N4O5S/c1-30-17-10-9-14(13-18(17)31(28,29)25-11-5-2-6-12-25)22-21(27)19-15-7-3-4-8-16(15)20(26)24-23-19/h3-4,7-10,13H,2,5-6,11-12H2,1H3,(H,22,27)(H,24,26)	CZXWEKRTGAVHJO-UHFFFAOYSA-N	42570	1-(5-(4-amino-6-(1,1- difluoroethyl)nicotinoyl)- 2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 183	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42570	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42570&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4876785	252623264							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79139	C=CC(=O)N1CC(O)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C19H19NS/c1-20(2)14-16-9-4-6-12-18(16)21-19-13-7-10-15-8-3-5-11-17(15)19/h3-13H,14H2,1-2H3	DGZUNQTZDDPLAE-UHFFFAOYSA-N	42571	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclopropylphenyl)-9- hydroxy-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 184	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42571&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			826626	252623265							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79140	C=CC(=O)N1CC(O)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C19H19NS/c1-20(2)14-16-9-4-6-12-18(16)21-19-13-7-10-15-8-3-5-11-17(15)19/h3-13H,14H2,1-2H3	DGZUNQTZDDPLAE-UHFFFAOYSA-N	42571	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclopropylphenyl)-9- hydroxy-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 184	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42571	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42571&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			826626	252623265							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79141	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc2c(C(F)(F)F)nn(C)c2c1)CC3	InChI=1S/C17H26N2O4S/c1-2-3-4-5-12-18-24(21,22)15-10-8-14(9-11-15)19-17(20)16-7-6-13-23-16/h8-11,16,18H,2-7,12-13H2,1H3,(H,19,20)	APXMICVTOJLGHL-UHFFFAOYSA-N	42572	1-(2-(4- cyclobutylphenyl)-5-(1- methyl-3- (trifluoromethyl)-1H- pyrazolo[4,3-b]pyridine- 6-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 185	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42572	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42572&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5132730	252623266							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79142	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1c(N)cc(C(F)(F)F)nc1N)CC3	InChI=1S/C18H21NOS/c1-19-13-11-15(12-14-19)20-17-9-5-6-10-18(17)21-16-7-3-2-4-8-16/h2-10,15H,11-14H2,1H3	CBYVLYPUADKSDZ-UHFFFAOYSA-N	42573	1-(2-(4- cyclopropylphenyl)-5- (2,4-diamino-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 186	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42573&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			667608	252623267							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79143	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1c(N)cc(C(F)(F)F)nc1N)CC3	InChI=1S/C18H21NOS/c1-19-13-11-15(12-14-19)20-17-9-5-6-10-18(17)21-16-7-3-2-4-8-16/h2-10,15H,11-14H2,1H3	CBYVLYPUADKSDZ-UHFFFAOYSA-N	42573	1-(2-(4- cyclopropylphenyl)-5- (2,4-diamino-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 186	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42573	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42573&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			667608	252623267							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79144	C=CC(=O)N1CC(OC)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C28H34N2O2/c1-31-26-16-8-9-17-27(26)32-23-11-10-18-29-19-21-30(22-20-29)28(24-12-4-2-5-13-24)25-14-6-3-7-15-25/h2-9,12-17,28H,10-11,18-23H2,1H3	LIVWJOWBAOASLL-UHFFFAOYSA-N	42575	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclopropylphenyl)-9- methoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 187	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42575&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2924100	252623269							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79145	C=CC(=O)N1CC(OC)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C28H34N2O2/c1-31-26-16-8-9-17-27(26)32-23-11-10-18-29-19-21-30(22-20-29)28(24-12-4-2-5-13-24)25-14-6-3-7-15-25/h2-9,12-17,28H,10-11,18-23H2,1H3	LIVWJOWBAOASLL-UHFFFAOYSA-N	42575	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclopropylphenyl)-9- methoxy- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 187	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=42575	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=42575&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2924100	252623269							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79146	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)C1=C2N=CN=C2C(Br)=CC1N)CC3	InChI=1S/C14H9N3O2/c18-17-13-7-6-11-10(14(13)16-19-17)8-12(15-11)9-4-2-1-3-5-9/h1-8,18H	AXSUDSRAJKDEFV-UHFFFAOYSA-N	43755	1-(5-(5-amino-7-bromo- 1H-benzo[d]imidazole- 4-carbonyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 188	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43755&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			690911	252624431							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79147	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C27H33N3O3S/c1-3-33-22-13-7-12-21(18-22)30(25(31)19-23-14-9-17-34-23)26(24-15-8-16-29(24)2)27(32)28-20-10-5-4-6-11-20/h7-9,12-18,20,26H,3-6,10-11,19H2,1-2H3,(H,28,32)	DHMLVPJKLCKZOH-UHFFFAOYSA-N	43756	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 189	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43756&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3191192	252624432							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79148	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C27H33N3O3S/c1-3-33-22-13-7-12-21(18-22)30(25(31)19-23-14-9-17-34-23)26(24-15-8-16-29(24)2)27(32)28-20-10-5-4-6-11-20/h7-9,12-18,20,26H,3-6,10-11,19H2,1-2H3,(H,28,32)	DHMLVPJKLCKZOH-UHFFFAOYSA-N	43756	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 189	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43756&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3191192	252624432							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79149	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)cc1N)CC3	InChI=1S/C12H9N3O2S/c1-8-4-2-6-14-10(8)13-12(18)15(14)11(16)9-5-3-7-17-9/h2-7H,1H3	WNIUKJQZBCDFAN-UHFFFAOYSA-N	43757	1-(5-(4-amino-6- bromonicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 190	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43757&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			705546	252624433							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79150	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)cc1N)CC3	InChI=1S/C17H21NO4/c1-21-15-6-3-13(4-7-15)5-8-16(19)18-11-9-14(10-12-18)17(20)22-2/h3-8,14H,9-12H2,1-2H3	WSFAXHLMQUUHQT-UHFFFAOYSA-N	43758	1-(5-(4-amino-6- bromonicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 191	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43758&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2162384	252624434							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79151	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(OC(F)F)cc1N)CC3	InChI=1S/C18H20N2O5S/c1-22-14-7-11(8-15(23-2)17(14)24-3)13-9-16(25-20-13)18(21)19-10-12-5-4-6-26-12/h4-8,16H,9-10H2,1-3H3,(H,19,21)	CKHXDQBENOJBPH-UHFFFAOYSA-N	43759	1-(5-(4-amino-6- (difluoromethoxy) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 192	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43759&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9551153	252624435							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79152	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(OC(F)F)cc1N)CC3	InChI=1S/C18H20N2O5S/c1-22-14-7-11(8-15(23-2)17(14)24-3)13-9-16(25-20-13)18(21)19-10-12-5-4-6-26-12/h4-8,16H,9-10H2,1-3H3,(H,19,21)	CKHXDQBENOJBPH-UHFFFAOYSA-N	43759	1-(5-(4-amino-6- (difluoromethoxy) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 192	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43759&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9551153	252624435							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79153	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)nc1N)CC3	InChI=1S/C19H13BrN4O2/c20-12-7-8-15-14(11-12)17(19(26)21-15)22-23-18(25)13-5-1-2-6-16(13)24-9-3-4-10-24/h1-11H,(H,23,25)(H,21,22,26)	RZDRDAZRRRXGPJ-UHFFFAOYSA-N	43760	1-(5-(2-amino-6- bromonicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 193	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43760&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6006008	252624436							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79154	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Br)nc1N)CC3	InChI=1S/C19H13BrN4O2/c20-12-7-8-15-14(11-12)17(19(26)21-15)22-23-18(25)13-5-1-2-6-16(13)24-9-3-4-10-24/h1-11H,(H,23,25)(H,21,22,26)	RZDRDAZRRRXGPJ-UHFFFAOYSA-N	43760	1-(5-(2-amino-6- bromonicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 193	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43760&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6006008	252624436							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79155	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C27H23N3O6S/c1-18(31)29-23-10-12-24(13-11-23)37(33,34)36-26-15-19(7-14-25(26)35-2)17-28-30-27(32)22-9-8-20-5-3-4-6-21(20)16-22/h3-17H,1-2H3,(H,29,31)(H,30,32)	ZNMWIEZYWYQUIH-UHFFFAOYSA-N	43761	1-(5-(4-amino-5-fluoro- 6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 194	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43761&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9660191	252624437							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79156	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C27H23N3O6S/c1-18(31)29-23-10-12-24(13-11-23)37(33,34)36-26-15-19(7-14-25(26)35-2)17-28-30-27(32)22-9-8-20-5-3-4-6-21(20)16-22/h3-17H,1-2H3,(H,29,31)(H,30,32)	ZNMWIEZYWYQUIH-UHFFFAOYSA-N	43761	1-(5-(4-amino-5-fluoro- 6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 194	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43761&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9660191	252624437							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79157	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C13H12ClN3S/c1-9-8-10(14)5-6-11(9)16-13(18)17-12-4-2-3-7-15-12/h2-8H,1H3,(H2,15,16,17,18)	BMYHYBZRMXACAK-UHFFFAOYSA-N	43762	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 195	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43762&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			667573	252624438							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79158	C=CC(=O)N1CC(C)c2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C13H12ClN3S/c1-9-8-10(14)5-6-11(9)16-13(18)17-12-4-2-3-7-15-12/h2-8H,1H3,(H2,15,16,17,18)	BMYHYBZRMXACAK-UHFFFAOYSA-N	43762	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)-9- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 195	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43762&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			667573	252624438							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79159	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Cl)cc1N)CC3	InChI=1S/C20H21N3O5/c1-25-16-7-5-6-12(18(16)27-3)11-21-23-20(24)15-10-13-14(22-15)8-9-17(26-2)19(13)28-4/h5-11,22H,1-4H3,(H,23,24)	RKSQGNNQXZLBHE-UHFFFAOYSA-N	43763	1-(5-(4-amino-6- chloronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 196	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43763&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6887243	252624439							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79160	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Cl)cc1N)CC3	InChI=1S/C20H21N3O5/c1-25-16-7-5-6-12(18(16)27-3)11-21-23-20(24)15-10-13-14(22-15)8-9-17(26-2)19(13)28-4/h5-11,22H,1-4H3,(H,23,24)	RKSQGNNQXZLBHE-UHFFFAOYSA-N	43763	1-(5-(4-amino-6- chloronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 196	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43763&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6887243	252624439							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79161	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)nc1N)CC3	InChI=1S/C22H17F2NO3/c23-18-7-1-15(2-8-18)13-25-21(26)14-28-20-11-5-17(6-12-20)22(27)16-3-9-19(24)10-4-16/h1-12H,13-14H2,(H,25,26)	RXJOOSRKNDQMBU-UHFFFAOYSA-N	43767	1-(5-(4-amino-2- (trifluoromethyl) pyrimidine- 5-carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 197	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43767&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2564901	252624443							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79162	C=CC(=O)N1CC(OC2CC(C#N)C2)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C14H10N2O2S/c17-12(13-6-3-7-19-13)8-11-14(18)16-10-5-2-1-4-9(10)15-11/h1-7H,8H2,(H,16,18)	QTHQCKXCYPEECX-UHFFFAOYSA-N	43770	3-((7-acryloyl-5-(4- amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclobutylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulen- 9-yl)oxy)cyclobutane-1- carbonitrile::US20250346600, Compound 198	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43770&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2517661	252624446							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79163	C=CC(=O)N1CC(OC2CC(C#N)C2)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C14H10N2O2S/c17-12(13-6-3-7-19-13)8-11-14(18)16-10-5-2-1-4-9(10)15-11/h1-7H,8H2,(H,16,18)	QTHQCKXCYPEECX-UHFFFAOYSA-N	43770	3-((7-acryloyl-5-(4- amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclobutylphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulen- 9-yl)oxy)cyclobutane-1- carbonitrile::US20250346600, Compound 198	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43770&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2517661	252624446							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79164	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Cl)nc1N)CC3	InChI=1S/C16H19N5O/c1-3-21(4-2)14-7-5-13(6-8-14)11-19-20-16(22)15-12-17-9-10-18-15/h5-12H,3-4H2,1-2H3,(H,20,22)	HZKMQOSQJCPWQD-UHFFFAOYSA-N	43771	1-(5-(2-amino-6- chloronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 199	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43771&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6883601	252624447							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79165	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(Cl)nc1N)CC3	InChI=1S/C16H19N5O/c1-3-21(4-2)14-7-5-13(6-8-14)11-19-20-16(22)15-12-17-9-10-18-15/h5-12H,3-4H2,1-2H3,(H,20,22)	HZKMQOSQJCPWQD-UHFFFAOYSA-N	43771	1-(5-(2-amino-6- chloronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 199	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43771&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6883601	252624447							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79166	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cc(F)c(C(F)(F)F)nc1N)CC3	InChI=1S/C18H15FN2OS/c1-22-17-9-5-3-7-14(17)16-10-11-18(21-20-16)23-12-13-6-2-4-8-15(13)19/h2-11H,12H2,1H3	WLNGNECPJIWIAF-UHFFFAOYSA-N	43772	1-(5-(2-amino-5-fluoro- 6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 200	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43772&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			7206036	252624448							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79167	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cc(F)c(C(F)(F)F)nc1N)CC3	InChI=1S/C18H15FN2OS/c1-22-17-9-5-3-7-14(17)16-10-11-18(21-20-16)23-12-13-6-2-4-8-15(13)19/h2-11H,12H2,1H3	WLNGNECPJIWIAF-UHFFFAOYSA-N	43772	1-(5-(2-amino-5-fluoro- 6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 200	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43772&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			7206036	252624448							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79168	C=CC(=O)N1CCc2nn(Cc3ccccc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C18H23N3O3S/c1-3-21(4-2)25(23,24)17-10-8-15(9-11-17)18(22)20-14-12-16-7-5-6-13-19-16/h5-11,13H,3-4,12,14H2,1-2H3,(H,20,22)	CTPCNZHBNPAZSS-UHFFFAOYSA-N	43773	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-benzyl- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 201	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43773&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2574266	252624449							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79169	C=CC(=O)N1CCc2nn(Cc3ccccc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C18H23N3O3S/c1-3-21(4-2)25(23,24)17-10-8-15(9-11-17)18(22)20-14-12-16-7-5-6-13-19-16/h5-11,13H,3-4,12,14H2,1-2H3,(H,20,22)	CTPCNZHBNPAZSS-UHFFFAOYSA-N	43773	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-benzyl- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 201	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43773&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2574266	252624449							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79170	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)c(F)c1N)CC3	InChI=1S/C16H14N4OS/c1-11(21)18-13-8-6-12(7-9-13)10-17-20-16-19-14-4-2-3-5-15(14)22-16/h2-9H,10H2,1H3,(H,18,21)	YHPDSGONSNFBIC-UHFFFAOYSA-N	43774	1-(5-(4-amino-6-bromo- 5-fluoronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 202	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43774&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896576	252624450							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79171	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Br)c(F)c1N)CC3	InChI=1S/C16H14N4OS/c1-11(21)18-13-8-6-12(7-9-13)10-17-20-16-19-14-4-2-3-5-15(14)22-16/h2-9H,10H2,1H3,(H,18,21)	YHPDSGONSNFBIC-UHFFFAOYSA-N	43774	1-(5-(4-amino-6-bromo- 5-fluoronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 202	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43774&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896576	252624450							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79172	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C15H14N2O3S/c1-10-2-4-12(21-10)9-16-17-15(18)11-3-5-13-14(8-11)20-7-6-19-13/h2-5,8-9H,6-7H2,1H3,(H,17,18)	IGIZYZMHUYYVJM-UHFFFAOYSA-N	43775	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-3- fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 203	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43775&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6883074	252624451							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79173	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(SC)nc1N)CC3	InChI=1S/C15H13N3OS/c1-18-9-5-8-12(18)10-13-14(19)17-15(20-13)16-11-6-3-2-4-7-11/h2-10H,1H3,(H,16,17,19)	LCISGORPEYFNGS-UHFFFAOYSA-N	43776	1-(5-(4-amino-2- (methylthio)pyrimidine- 5-carbonyl)-2-(4- cyclopropylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 204	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43776&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			941925	252624452							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79174	C=CC(=O)N1CC2c3c(nn(-c4ccc(C5CCC5)cc4)c3CCN2C(=O)c2ccc(C(F)(F)F)nc2)[C@@H](OC2CN(C(C)=O)C2)C1	InChI=1S/C18H15N3O3/c1-22-14-7-3-12(4-8-14)17-21-16(11-19)18(24-17)20-13-5-9-15(23-2)10-6-13/h3-10,20H,1-2H3	QZTRFKCNOMGWIX-UHFFFAOYSA-N	43777	1-(9-((1-acetylazetidin- 3-yl)oxy)-2-(4- cyclobutylphenyl)-5-(6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 205	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43777&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			950402	252624453							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79175	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(C)(F)F)c(F)c1N)CC3	InChI=1S/C21H19N3OS3/c1-13-11-26-20-18(13)14(2)19(28-20)16-8-9-22-21(24-16)27-12-17(25)23-10-15-6-4-3-5-7-15/h3-9,11H,10,12H2,1-2H3,(H,23,25)	BEPAWDAAQCAFBH-UHFFFAOYSA-N	43778	1-(5-(4-amino-6-(1,1- difluoroethyl)-5- fluoronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 206	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43778&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2820576	252624454							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79176	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(C)(F)F)c(F)c1N)CC3	InChI=1S/C21H19N3OS3/c1-13-11-26-20-18(13)14(2)19(28-20)16-8-9-22-21(24-16)27-12-17(25)23-10-15-6-4-3-5-7-15/h3-9,11H,10,12H2,1-2H3,(H,23,25)	BEPAWDAAQCAFBH-UHFFFAOYSA-N	43778	1-(5-(4-amino-6-(1,1- difluoroethyl)-5- fluoronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 206	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=43778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=43778&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2820576	252624454							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79177	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cc(C#N)c(C(F)(F)F)cc1N)CC3	InChI=1S/C17H24FN3O3/c1-2-24-17(23)21-11-7-15(8-12-21)19-9-10-20-16(22)13-3-5-14(18)6-4-13/h3-6,15,19H,2,7-12H2,1H3,(H,20,22)	XZDFHPRXDQKPOH-UHFFFAOYSA-N	44250	5-(7-acryloyl-2-(4- cyclopropyl-2- hydroxyphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulene- 5-carbonyl)-4-amino-2- (trifluoromethyl) benzonitrile::US20250346600, Compound 207	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44250	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44250&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3156884	252624876							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79178	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(C)c1N)CC3	InChI=1S/C17H24FN3O3/c1-2-24-17(23)21-10-6-15(7-11-21)19-8-9-20-16(22)13-4-3-5-14(18)12-13/h3-5,12,15,19H,2,6-11H2,1H3,(H,20,22)	VZWNZOWARCSQMF-UHFFFAOYSA-N	44251	1-(5-(4-amino-5-methyl- 6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 208	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44251	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44251&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			25010829	252624877							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79179	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(SC(F)(F)F)cc1N)CC3	InChI=1S/C17H23F2N3O3/c1-2-25-17(24)22-9-5-13(6-10-22)20-7-8-21-16(23)12-3-4-14(18)15(19)11-12/h3-4,11,13,20H,2,5-10H2,1H3,(H,21,23)	WBKCHECFGLABAB-UHFFFAOYSA-N	44252	1-(5-(4-amino-6- ((trifluoromethyl)thio) nicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 209	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44252	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44252&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			25010835	252624878							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79180	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(Cl)c(F)c1N)CC3	InChI=1S/C18H27N3O4/c1-3-25-18(23)21-11-7-15(8-12-21)19-9-10-20-17(22)14-5-4-6-16(13-14)24-2/h4-6,13,15,19H,3,7-12H2,1-2H3,(H,20,22)	WSJRIQQJGRDSQK-UHFFFAOYSA-N	44253	1-(5-(4-amino-6-chloro- 5-fluoronicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 210	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=44253	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=44253&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			25010851	252624879							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79181	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(SC)cc1N)CC3	InChI=1S/C8H15N5O/c1-6-7(9-4-5-13(2)3)10-8(14)12-11-6/h4-5H2,1-3H3,(H2,9,10,12,14)	PBMFJQHGZTXUDY-UHFFFAOYSA-N	46440	1-(5-(4-amino-6- (methylthio)nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 211	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46440	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46440&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			656005	252626997							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79182	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)C1=C2N=CN=C2C(Br)=CC1N)CC3	InChI=1S/C9H9NO3/c1-5(11)6-2-8-9(3-7(6)10)13-4-12-8/h2-3H,4,10H2,1H3	DWTHYSZSRJOMSC-UHFFFAOYSA-N	46441	1-(5-(6-amino-4-bromo- 1H-benzo[d]imidazole- 7-carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 212	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46441	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46441&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			120000	252626998							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79183	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1)CC3	InChI=1S/C13H19N/c1-8-5-6-12-9(2)7-10(3)14-13(12)11(8)4/h5-6,9-10,14H,7H2,1-4H3	WIDSWFNCHJKVGT-UHFFFAOYSA-N	46442	1-(2-(4-cyclopropyl-2- hydroxyphenyl)-5-(6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 213	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46442	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46442&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			661124	252626999							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79184	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(SC(F)(F)F)c(F)c1N)CC3	InChI=1S/C17H25NO5/c1-3-4-10-22-16(20)13-12-6-7-17(23-12)11-18(8-5-9-21-2)15(19)14(13)17/h6-7,12-14H,3-5,8-11H2,1-2H3	PLKDAZVAABCOJG-UHFFFAOYSA-N	46443	1-(5-(4-amino-5-fluoro- 6- ((trifluoromethyl)thio) nicotinoyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 214	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46443	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46443&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5389826	242053087							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79185	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(Br)cc1N)CC3	InChI=1S/C16H19NO5/c1-21-12-8-6-11(7-9-12)16(20)17-10-15(19)22-14-5-3-2-4-13(14)18/h6-9,14H,2-5,10H2,1H3,(H,17,20)	WMVMPQOOVMRGMW-UHFFFAOYSA-N	46444	1-(5-(4-amino-6- bromonicotinoyl)-2-(4- cyclopropyl-3-fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 215	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46444	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46444&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2998743	252627000							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79186	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(OC)c1N)CC3	InChI=1S/C10H13N3O2S2/c1-10(2,3)13-17(14,15)8-6-4-5-7-9(8)12-16-11-7/h4-6,13H,1-3H3	MWTKVTBMDVSPBB-UHFFFAOYSA-N	46445	1-(5-(4-amino-5- methoxy-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 216	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46445	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46445&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3236846	252627001							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79187	C=CC(=O)N1CCc2nn(-c3ccc(C4CCCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C15H21FN2O3S/c1-2-22(20,21)18-9-7-13(8-10-18)15(19)17-11-12-3-5-14(16)6-4-12/h3-6,13H,2,7-11H2,1H3,(H,17,19)	MAFDVQFXODFPNK-UHFFFAOYSA-N	46446	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopentyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 217	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46446	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46446&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3237090	252627002							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79188	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C15H17N3O4/c1-10-2-4-11(5-3-10)17-13(19)9-22-14(20)7-6-12-8-16-15(21)18-12/h2-5,8H,6-7,9H2,1H3,(H,17,19)(H2,16,18,21)	NJJZAYDQUWIFRJ-UHFFFAOYSA-N	46448	1-(5-(4-amino-5-fluoro- 6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-3- fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 218	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46448	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46448&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			753474	252627004							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79189	C=CC(=O)N1CCc2nn(-c3ccc(C45CC(C6CCCC6)(C4)C5)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C11H13N3O3S/c1-7-6-18-11-13-8(5-14(7)11)4-12-9(15)2-3-10(16)17/h5-6H,2-4H2,1H3,(H,12,15)(H,16,17)	SWXVHOMXUBDPGH-UHFFFAOYSA-N	46450	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(3- cyclopentylbicyclo[1.1.1] pentan-1-yl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 219	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46450	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46450&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			5310272	252627006							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79190	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1c(N)nc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C13H14FN3O2S/c1-15-13-17(2)12(19)10(20-13)7-11(18)16-9-6-4-3-5-8(9)14/h3-6,10H,7H2,1-2H3,(H,16,18)	YCSNRPBNJIJNDF-UHFFFAOYSA-N	46451	1-(2-(4- cyclopropylphenyl)-5- (2,4-diamino-5-fluoro-6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 220	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46451	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46451&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3441571	252627007							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79191	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1C)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C13H12N2O3/c1-8-5-9(2)15(14-8)13(16)10-3-4-11-12(6-10)18-7-17-11/h3-6H,7H2,1-2H3	IXCICYVXWKMZOL-UHFFFAOYSA-N	46453	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)-6- methyl-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 221	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46453	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46453&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			686254	252627009							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79192	C=CC(=O)N1CC(OC2CC(C#N)C2)c2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C11H10N2O3/c1-16-10(14)6-9-7-4-2-3-5-8(7)11(15)13-12-9/h2-5H,6H2,1H3,(H,13,15)	IXLXNBZGLAHSDI-UHFFFAOYSA-N	46454	3-((7-acryloyl-5-(4- amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulen- 9-yl)oxy)cyclobutane-1- carbonitrile::US20250346600, Compound 222	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46454	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46454&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			778234	252627010							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79193	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(SC)c(F)c1N)CC3	InChI=1S/C10H12BrNO3/c1-3-15-8-5-6(10(12)13)4-7(11)9(8)14-2/h4-5H,3H2,1-2H3,(H2,12,13)	AGMUJEZTMQRKPI-UHFFFAOYSA-N	46455	1-(5-(4-amino-5-fluoro- 6- (methylthio)nicotinoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 223	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46455	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46455&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			900806	252627011							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79194	C=CC(=O)N1CCc2nn(-c3cc(F)c(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C16H15N3O2S3/c1-10-7-23-16(17-10)24-9-14(20)19-15-18-13(8-22-15)11-3-5-12(21-2)6-4-11/h3-8H,9H2,1-2H3,(H,18,19,20)	MEDCWZMCXFJAHF-UHFFFAOYSA-N	46456	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-5- fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 224	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46456	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46456&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1235810	252627012							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79195	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3CO)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C11H13N3O/c1-2-5-10-13-9-7-4-3-6-8(9)11(15)14(10)12/h3-4,6-7H,2,5,12H2,1H3	CXGQPWUJPOEWIF-UHFFFAOYSA-N	46458	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- (hydroxymethyl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 225	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46458	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46458&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			805142	252627014							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79196	C=CC(=O)N1CCc2nn(-c3ccc(SC(F)(F)F)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C10H15N3OS2/c1-7-12-13-10(16-7)15-6-9(14)11-8-4-2-3-5-8/h8H,2-6H2,1H3,(H,11,14)	WOEWVUCFBKRTEM-UHFFFAOYSA-N	46459	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(2-hydroxy-4- ((trifluoromethyl)thio) phenyl)-2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 226	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46459	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46459&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			895382	252627015							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79197	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(C)(F)F)c(F)c1N)CC3	InChI=1S/C16H16N2O2S/c1-10-8-11(2)15(12(3)9-10)17-16-13-6-4-5-7-14(13)21(19,20)18-16/h4-9H,1-3H3,(H,17,18)	GGCVEYAQRYFNCA-UHFFFAOYSA-N	46460	1-(5-(4-amino-6-(1,1- difluoroethyl)-5- fluoronicotinoyl)-2-(4- cyclopropyl-3-fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 227	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46460	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46460&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			733262	252627016							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79198	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1nnc(Br)cc1N)CC3	InChI=1S/C15H23N3O/c1-13-7-2-3-8-14(13)17-15(19)16-9-6-12-18-10-4-5-11-18/h2-3,7-8H,4-6,9-12H2,1H3,(H2,16,17,19)	KKBKFZUVDXWFKD-UHFFFAOYSA-N	46461	1-(5-(4-amino-6- bromopyridazine-3- carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 228	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46461	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46461&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2967096	252627017							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79199	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C20H38N4O7/c1-21-3-9-28-15-16-29-10-4-22(2)20(26)24-6-12-27-11-5-23(19(21)25)7-13-30-17-18-31-14-8-24/h3-18H2,1-2H3	ULYSKSKJXOTZMX-UHFFFAOYSA-N	46462	1-(5-(4-amino-6-bromo- 5-fluoronicotinoyl)-2-(4- cyclopropyl-3-fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 229	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46462	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46462&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3619949	252627018							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79200	C=CC(=O)N1CC2c3c(nn(-c4ccc(C5CC5)cc4)c3CCN2C(=O)c2ccc(C(F)(F)F)cc2)C(n2ccccc2=O)C1	InChI=1S/C20H29N5O5/c1-20(2,3)30-19(28)24-8-5-13(6-9-24)15-11-16(26)25-17(23-15)14(12-22-25)18(27)21-7-10-29-4/h11-13,22H,5-10H2,1-4H3,(H,21,27)	BYTUOSHJRGSFFW-UHFFFAOYSA-N	46463	1-(7-acryloyl-2-(4- cyclopropylphenyl)-5-(4- (trifluoromethyl)benzoyl)- 3,4,5,5a,6,7,8,9- octahydro-2H-1,2,5,7- tetraazabenzo[cd]azulen- 9-yl)pyridin-2(1H)-one::US20250346600, Compound 231	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46463	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46463&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			9551340	252627019							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79201	C=CC(=O)N1CC(OC2CC2)c2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C12H12O4/c1-3-15-12(14)11-7(2)16-10-5-4-8(13)6-9(10)11/h4-6,13H,3H2,1-2H3	KSNVFCJUBJUTPF-UHFFFAOYSA-N	46464	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 9-cyclopropoxy-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 232	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46464	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46464&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			81704	252627020							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79202	C=CC(=O)N1CC2c3c(nn(-c4ccc(C5CC5)cc4)c3CCN2C(=O)c2cnc(C(F)(F)F)cc2N)C2(C1)CN(c1nnc(C)s1)C2			46465	1-(5'-(4-amino-6- (trifluoromethyl) nicotinoyl)-2'-(4- cyclopropylphenyl)-1-(5- methyl-1,3,4-thiadiazol- 2-yl)-2',3',4',5',5a',6'- hexahydro-1',2',5',7'- tetraazaspiro[azetidine- 3,9'-benzo[cd]azulen]- 1'(9a'),2a'-dien-7'(8'H)- yl)prop-2-en-1-one::US20250346600, Compound 233	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46465	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46465&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2930822	252627021							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79203	C=CC(=O)N1CC(OCc2cnc3sccn23)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1)CC3	InChI=1S/C18H18O6/c1-21-17(19)13-3-7-15(8-4-13)23-11-12-24-16-9-5-14(6-10-16)18(20)22-2/h3-10H,11-12H2,1-2H3	BBCJQHYOGQEOAA-UHFFFAOYSA-N	46466	1-(2-(4- cyclopropylphenyl)-9- (imidazo[2,1-b]thiazol-5- ylmethoxy)-5-(6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 234	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46466	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46466&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			77875	252627022							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79204	C=CC(=O)N1CC(OC2(COC)CC2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)nc1)CC3	InChI=1S/C19H29N5O/c1-14(2)19(25)20-15-5-6-17-16(13-15)21-18(23(17)4)7-8-24-11-9-22(3)10-12-24/h5-6,13-14H,7-12H2,1-4H3,(H,20,25)	QLKUILUSFPFJTO-UHFFFAOYSA-N	46467	1-(2-(4- cyclopropylphenyl)-9-(1- (methoxymethyl) cyclopropoxy)-5-(6- (trifluoromethyl) nicotinoyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 235	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46467	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46467&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			4888292	252627023							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79205	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)C1=CC=C2C(Cl)=NCN2C1)CC3	InChI=1S/C17H7F9N2O/c18-15(19,20)8-2-1-3-9(6-8)29-13-5-4-10-11(16(21,22)23)7-12(17(24,25)26)27-14(10)28-13/h1-7H	PADXYYGFOOEZSF-UHFFFAOYSA-N	46469	1-(5-(1- chloroimidazo[1,5- a]pyridine-6-carbonyl)- 2-(4-cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 236	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46469	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46469&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2768569	252627025							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79206	C=CC(=O)N1CCc2nc(-c3ccc(C4CCC4)cc3)n3c2C(C1)N(C(=O)c1ccc(Br)c2[nH]c(C(F)F)nc12)CC3	InChI=1S/C11H9N6O4/c18-9-4-2-1-3-8(9)5-13-14-10(19)6-16-7-12-11(15-16)17(20)21/h1-5,7H,6H2,(H,14,19)/q-1/p+1	HVWOAOZBFNHYKM-UHFFFAOYSA-O	46470	1-(5-(7-bromo-2- (difluoromethyl)-1H- benzo[d]imidazole-4- carbonyl)-2-(4- cyclobutylphenyl)- 4,5,5a,6,8,9-hexahydro- 1,2a,5,7- tetraazabenzo[cd]azulen- 7(3H)-yl)prop-2-en-1- one::US20250346600, Compound 237	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46470	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46470&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6537566	252627026							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79207	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C13H11N3O/c17-13(12-4-2-1-3-5-12)16-15-10-11-6-8-14-9-7-11/h1-10H,(H,16,17)	IDBRDJFOFNLZRV-UHFFFAOYSA-N	46471	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclobutylphenyl)- 4,5,5a,6,8,9-hexahydro- 1,2a,5,7- tetraazabenzo[cd]azulen- 7(3H)-yl)prop-2-en-1- one::US20250346600, Compound 238	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46471	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46471&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6862726	252627027							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79208	COC/C=C/C(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C10H10Cl2N4/c1-6(2)16-10(13-14-15-16)7-3-8(11)5-9(12)4-7/h3-6H,1-2H3	VRBPCAHAXLWUAZ-UHFFFAOYSA-N	46472	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)-4-methoxybut-2- en-1-one::US20250346600, Compound 239	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46472&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1490179	252627028							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79209	COC/C=C/C(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C10H10Cl2N4/c1-6(2)16-10(13-14-15-16)7-3-8(11)5-9(12)4-7/h3-6H,1-2H3	VRBPCAHAXLWUAZ-UHFFFAOYSA-N	46472	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)-4-methoxybut-2- en-1-one::US20250346600, Compound 239	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46472	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46472&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1490179	252627028							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79210	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3C)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C11H11N3OS/c15-10(7-5-6-7)13-14-11-12-8-3-1-2-4-9(8)16-11/h1-4,7H,5-6H2,(H,12,14)(H,13,15)	XGBXXXNEGNJDPP-UHFFFAOYSA-N	46473	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- methylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 240	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46473&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			872713	252627029							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79211	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3C)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C11H11N3OS/c15-10(7-5-6-7)13-14-11-12-8-3-1-2-4-9(8)16-11/h1-4,7H,5-6H2,(H,12,14)(H,13,15)	XGBXXXNEGNJDPP-UHFFFAOYSA-N	46473	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclobutyl-2- methylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 240	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46473	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46473&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			872713	252627029							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79212	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3Cl)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C13H15NO4/c1-9(13(16)17)14-12(15)8-5-10-3-6-11(18-2)7-4-10/h3-9H,1-2H3,(H,14,15)(H,16,17)	WUVZUPQRHXCIKE-UHFFFAOYSA-N	46474	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(2-chloro-4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 241	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46474&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			7909375	252627030							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79213	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3Cl)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C13H15NO4/c1-9(13(16)17)14-12(15)8-5-10-3-6-11(18-2)7-4-10/h3-9H,1-2H3,(H,14,15)(H,16,17)	WUVZUPQRHXCIKE-UHFFFAOYSA-N	46474	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(2-chloro-4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 241	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46474	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46474&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			7909375	252627030							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79214	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2ncncc12)CC3	InChI=1S/C18H14ClN5/c1-11-6-7-12-9-13(17(19)21-16(12)8-11)10-20-24-18-22-14-4-2-3-5-15(14)23-18/h2-9H,10H2,1H3,(H,22,23)	JUSARNASDBBMRA-UHFFFAOYSA-N	46475	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(8- (trifluoromethyl) quinazoline- 5-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 242	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46475&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896682	252627031							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79215	C=CC(=O)N1CCc2nn(-c3ccc(C4CCC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c2ncncc12)CC3	InChI=1S/C18H14ClN5/c1-11-6-7-12-9-13(17(19)21-16(12)8-11)10-20-24-18-22-14-4-2-3-5-15(14)23-18/h2-9H,10H2,1H3,(H,22,23)	JUSARNASDBBMRA-UHFFFAOYSA-N	46475	1-(2-(4-cyclobutyl-2- hydroxyphenyl)-5-(8- (trifluoromethyl) quinazoline- 5-carbonyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 242	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46475	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46475&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896682	252627031							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79216	Nc1cc(C(F)(F)F)ncc1C(=O)N1CCc2c3c(nn2-c2ccc(C4CCC4)cc2)CCN(C(=O)/C=C\Cl)CC31	InChI=1S/C21H23N3O4S/c1-4-28-17-11-13(5-10-16(17)25)19-18(12(2)22-21(29)24-19)20(26)23-14-6-8-15(27-3)9-7-14/h5-11,18-19,25H,4H2,1-3H3,(H,23,26)(H,24,29)	VJNFCBBHFDGNSX-UHFFFAOYSA-N	46476	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)-3-chloroprop-2-en- 1-one::US20250346600, Compound 243	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46476&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896683	252627032							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79217	Nc1cc(C(F)(F)F)ncc1C(=O)N1CCc2c3c(nn2-c2ccc(C4CCC4)cc2)CCN(C(=O)/C=C\Cl)CC31	InChI=1S/C21H23N3O4S/c1-4-28-17-11-13(5-10-16(17)25)19-18(12(2)22-21(29)24-19)20(26)23-14-6-8-15(27-3)9-7-14/h5-11,18-19,25H,4H2,1-3H3,(H,23,26)(H,24,29)	VJNFCBBHFDGNSX-UHFFFAOYSA-N	46476	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)-3-chloroprop-2-en- 1-one::US20250346600, Compound 243	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46476	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46476&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			91896683	252627032							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79218	C=CC(=O)N1CCc2nn(-c3cc(F)c(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C16H16O3/c1-18-15-9-8-13(11-16(15)19-2)14(17)10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3	PCHUBNOSEWYQAT-UHFFFAOYSA-N	46477	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-3,5- difluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 244	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46477&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			678663	252627033							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79219	C=CC(=O)N1CCc2nn(-c3cc(F)c(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C16H16O3/c1-18-15-9-8-13(11-16(15)19-2)14(17)10-12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3	PCHUBNOSEWYQAT-UHFFFAOYSA-N	46477	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-3,5- difluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 244	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46477	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46477&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			678663	252627033							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79220	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)cc1N)CC3	InChI=1S/C20H23N3O4S/c24-19(15-7-8-15)21-22-20(25)17-6-3-11-23(13-17)28(26,27)18-10-9-14-4-1-2-5-16(14)12-18/h1-2,4-5,9-10,12,15,17H,3,6-8,11,13H2,(H,21,24)(H,22,25)	HNNLXBNEBGDRSU-UHFFFAOYSA-N	46478	1-(5-(2-amino-4- (trifluoromethyl)benzoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 245	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46478&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3230758	252627034							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79221	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)cc1N)CC3	InChI=1S/C20H23N3O4S/c24-19(15-7-8-15)21-22-20(25)17-6-3-11-23(13-17)28(26,27)18-10-9-14-4-1-2-5-16(14)12-18/h1-2,4-5,9-10,12,15,17H,3,6-8,11,13H2,(H,21,24)(H,22,25)	HNNLXBNEBGDRSU-UHFFFAOYSA-N	46478	1-(5-(2-amino-4- (trifluoromethyl)benzoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 245	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46478	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46478&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			3230758	252627034							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79222	C=CC(=O)N1CC(OC2CC3(COC3)C2)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C18H17NO6/c1-10-3-4-11(2)15(5-10)25-9-16(20)19-14-7-12(17(21)22)6-13(8-14)18(23)24/h3-8H,9H2,1-2H3,(H,19,20)(H,21,22)(H,23,24)	GGOPAQBAMXZPPG-UHFFFAOYSA-N	46479	1-(9-((2- oxaspiro[3.3]heptan-6- yl)oxy)-5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H- benzo[cd]azulen-7- yl)prop-2-en-1-one::US20250346600, Compound 246	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46479&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			976437	252627035							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79223	C=CC(=O)N1CC(OC2CC3(COC3)C2)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C18H17NO6/c1-10-3-4-11(2)15(5-10)25-9-16(20)19-14-7-12(17(21)22)6-13(8-14)18(23)24/h3-8H,9H2,1-2H3,(H,19,20)(H,21,22)(H,23,24)	GGOPAQBAMXZPPG-UHFFFAOYSA-N	46479	1-(9-((2- oxaspiro[3.3]heptan-6- yl)oxy)-5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclobutylphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H- benzo[cd]azulen-7- yl)prop-2-en-1-one::US20250346600, Compound 246	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46479	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46479&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			976437	252627035							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79224	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(OC(F)(F)F)c(F)c1N)CC3	InChI=1S/C14H9BrN2O2S2/c15-9-3-1-8(2-4-9)10-5-20-13-12(10)14(17-7-16-13)21-6-11(18)19/h1-5,7H,6H2,(H,18,19)	OFSQPNMSDPKEQI-UHFFFAOYSA-N	46480	1-(5-(4-amino-5-fluoro- 6- (trifluoromethoxy) nicotinoyl)- 2-(4-cyclopropyl- 2-hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 247	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46480&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1191742	252627036							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79225	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(OC(F)(F)F)c(F)c1N)CC3	InChI=1S/C14H9BrN2O2S2/c15-9-3-1-8(2-4-9)10-5-20-13-12(10)14(17-7-16-13)21-6-11(18)19/h1-5,7H,6H2,(H,18,19)	OFSQPNMSDPKEQI-UHFFFAOYSA-N	46480	1-(5-(4-amino-5-fluoro- 6- (trifluoromethoxy) nicotinoyl)- 2-(4-cyclopropyl- 2-hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 247	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46480	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46480&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1191742	252627036							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79226	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1nnc(C(F)(F)F)cc1N)CC3	InChI=1S/C20H22N4O6S/c25-19(22-12-15-3-1-2-6-21-15)13-24-17-11-16(4-5-18(17)30-14-20(24)26)31(27,28)23-7-9-29-10-8-23/h1-6,11H,7-10,12-14H2,(H,22,25)	PGRRIXRCXBMOOT-UHFFFAOYSA-N	46481	1-(5-(4-amino-6- (trifluoromethyl) pyridazine- 3-carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 248	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46481&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16189325	252627037							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79227	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1nnc(C(F)(F)F)cc1N)CC3	InChI=1S/C20H22N4O6S/c25-19(22-12-15-3-1-2-6-21-15)13-24-17-11-16(4-5-18(17)30-14-20(24)26)31(27,28)23-7-9-29-10-8-23/h1-6,11H,7-10,12-14H2,(H,22,25)	PGRRIXRCXBMOOT-UHFFFAOYSA-N	46481	1-(5-(4-amino-6- (trifluoromethyl) pyridazine- 3-carbonyl)-2-(4- cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 248	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46481	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46481&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16189325	252627037							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79228	C=CC(=O)N1CC(OCc2nnc(C)s2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C17H18N2O3/c1-3-12-6-4-5-11(2)16(12)19-17(20)18-13-7-8-14-15(9-13)22-10-21-14/h4-9H,3,10H2,1-2H3,(H2,18,19,20)	KZTFIHDMQCCISF-UHFFFAOYSA-N	46482	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)-9- ((5-methyl-1,3,4- thiadiazol-2- yl)methoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 249	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46482&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6469647	252627038							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79229	C=CC(=O)N1CC(OCc2nnc(C)s2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C17H18N2O3/c1-3-12-6-4-5-11(2)16(12)19-17(20)18-13-7-8-14-15(9-13)22-10-21-14/h4-9H,3,10H2,1-2H3,(H2,18,19,20)	KZTFIHDMQCCISF-UHFFFAOYSA-N	46482	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)-9- ((5-methyl-1,3,4- thiadiazol-2- yl)methoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 249	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46482	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46482&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6469647	252627038							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79230	C=CC(=O)N1CC(OCc2ncco2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C10H10F2N2O/c1-2-5-13-10(15)14-9-4-3-7(11)6-8(9)12/h2-4,6H,1,5H2,(H2,13,14,15)	JDXPLWOPYBGOBC-UHFFFAOYSA-N	46483	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)-9- (oxazol-2-ylmethoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 250	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46483&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6470768	252627039							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79231	C=CC(=O)N1CC(OCc2ncco2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C10H10F2N2O/c1-2-5-13-10(15)14-9-4-3-7(11)6-8(9)12/h2-4,6H,1,5H2,(H2,13,14,15)	JDXPLWOPYBGOBC-UHFFFAOYSA-N	46483	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)-9- (oxazol-2-ylmethoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 250	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46483	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46483&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			6470768	252627039							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79232	C=CC(=O)N1CC(OCc2cccnc2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C18H19NO3/c1-3-14(13-8-5-4-6-9-13)17(20)19-16-11-7-10-15(12(16)2)18(21)22/h4-11,14H,3H2,1-2H3,(H,19,20)(H,21,22)	BNRCHWPFXNDZQS-UHFFFAOYSA-N	46484	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)-9- (pyridin-3-ylmethoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 251	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46484&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2966060	252627040							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79233	C=CC(=O)N1CC(OCc2cccnc2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C18H19NO3/c1-3-14(13-8-5-4-6-9-13)17(20)19-16-11-7-10-15(12(16)2)18(21)22/h4-11,14H,3H2,1-2H3,(H,19,20)(H,21,22)	BNRCHWPFXNDZQS-UHFFFAOYSA-N	46484	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)-9- (pyridin-3-ylmethoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 251	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46484	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46484&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2966060	252627040							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79234	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3OC(F)F)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C21H22FN5O3S/c1-27-18(11-12-19(28)23-15-8-4-3-7-14(15)22)25-26-21(27)31-13-20(29)24-16-9-5-6-10-17(16)30-2/h3-10H,11-13H2,1-2H3,(H,23,28)(H,24,29)	FOUSBIWHXJFEHP-UHFFFAOYSA-N	46485	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- (difluoromethoxy)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 252	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46485&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2971905	252627041							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79235	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3OC(F)F)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C21H22FN5O3S/c1-27-18(11-12-19(28)23-15-8-4-3-7-14(15)22)25-26-21(27)31-13-20(29)24-16-9-5-6-10-17(16)30-2/h3-10H,11-13H2,1-2H3,(H,23,28)(H,24,29)	FOUSBIWHXJFEHP-UHFFFAOYSA-N	46485	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- (difluoromethoxy)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 252	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46485	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46485&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2971905	252627041							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79236	C=CC(=O)N1CCc2nn(-c3cc(F)c(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(C)(F)F)c(F)c1N)CC3	InChI=1S/C12H13Cl3N2O2/c1-6-4-7(2)9(8(3)5-6)16-11(19)17-10(18)12(13,14)15/h4-5H,1-3H3,(H2,16,17,18,19)	IRGKVHGXRKWNMU-UHFFFAOYSA-N	46486	1-[7-[4-amino-6-(1,1- difluoroethyl)-5-fluoro- pyridine-3-carbonyl]-3- (4-cyclopropyl-5-fluoro- 2-hydroxy-phenyl)- 2,3,7,10- tetrazatricyclo[6.4.1.04,1 3]trideca-1,4(13)-dien- 10-yl]prop-2-en-1-one::US20250346600, Compound 253	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46486	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46486&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			888622	252627042							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79237	C=CC(=O)N1CCc2nn(-c3cc(F)c(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(OC(F)(F)F)c(F)c1N)CC3	InChI=1S/C11H7Cl2NO/c12-7-1-3-9(10(13)5-7)11-4-2-8(6-15)14-11/h1-6,14H	SFCHNSMCZGBOTP-UHFFFAOYSA-N	46487	1-(5-(4-amino-5-fluoro- 6- (trifluoromethoxy) nicotinoyl)- 2-(4-cyclopropyl- 5-fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 254	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46487	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46487&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			940965	252627043							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79238	C=CC(=O)N1CC(OCC2CCOCC2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C11H14N2O3S/c1-8(2)7-13-10-6-4-3-5-9(10)12-11(13)17(14,15)16/h3-6,8H,7H2,1-2H3,(H,14,15,16)	HAXCIDOKZMLZAV-UHFFFAOYSA-N	46488	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)-9- ((tetrahydro-2H-pyran-4- yl)methoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 255	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46488&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2908258	252627044							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79239	C=CC(=O)N1CC(OCC2CCOCC2)c2nn(-c3ccc(C4CC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C11H14N2O3S/c1-8(2)7-13-10-6-4-3-5-9(10)12-11(13)17(14,15)16/h3-6,8H,7H2,1-2H3,(H,14,15,16)	HAXCIDOKZMLZAV-UHFFFAOYSA-N	46488	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)-2-(4- cyclopropylphenyl)-9- ((tetrahydro-2H-pyran-4- yl)methoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 255	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46488	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46488&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			2908258	252627044							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79240	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3C(F)(F)F)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C20H14N2O2S/c23-20(24)15-10-8-14(9-11-15)19-21-17(13-5-2-1-3-6-13)18(22-19)16-7-4-12-25-16/h1-12H,(H,21,22)(H,23,24)	JPDDFHHRTBLTJP-UHFFFAOYSA-N	46489	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- (trifluoromethyl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 256	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46489&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			828883	252627045							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79241	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3C(F)(F)F)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C20H14N2O2S/c23-20(24)15-10-8-14(9-11-15)19-21-17(13-5-2-1-3-6-13)18(22-19)16-7-4-12-25-16/h1-12H,(H,21,22)(H,23,24)	JPDDFHHRTBLTJP-UHFFFAOYSA-N	46489	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4-cyclopropyl-2- (trifluoromethyl)phenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 256	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46489	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46489&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			828883	252627045							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79242	CS(=O)(=O)/C=C/CN1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C12H14N4O3/c1-7-11(17)14-12(16-15-7)13-9-5-4-8(18-2)6-10(9)19-3/h4-6H,1-3H3,(H2,13,14,16,17)	JQITULKPBZYIKU-UHFFFAOYSA-N	46490	(4-amino-6- (trifluoromethyl)pyridin- 3-yl)(2-(4-cyclopropyl- 2-hydroxyphenyl)-7-(3- (methylsulfonyl)allyl)- 3,4,6,7,8,9-hexahydro- 2H-1,2,5,7- tetraazabenzo[cd]azulen- 5(5aH)-yl)methanone::US20250346600, Compound 257	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46490&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			756464	252627046							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79243	CS(=O)(=O)/C=C/CN1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C12H14N4O3/c1-7-11(17)14-12(16-15-7)13-9-5-4-8(18-2)6-10(9)19-3/h4-6H,1-3H3,(H2,13,14,16,17)	JQITULKPBZYIKU-UHFFFAOYSA-N	46490	(4-amino-6- (trifluoromethyl)pyridin- 3-yl)(2-(4-cyclopropyl- 2-hydroxyphenyl)-7-(3- (methylsulfonyl)allyl)- 3,4,6,7,8,9-hexahydro- 2H-1,2,5,7- tetraazabenzo[cd]azulen- 5(5aH)-yl)methanone::US20250346600, Compound 257	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			>55							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46490	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46490&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			756464	252627046							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79244	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(OC(F)(F)F)c(F)c1N)CC3	InChI=1S/C15H20N2O3/c1-11(2)16(12(3)4)15(18)9-8-13-6-5-7-14(10-13)17(19)20/h5-12H,1-4H3	DIVHLQIHPPWRRY-UHFFFAOYSA-N	46491	1-(5-(4-amino-5-fluoro- 6- (trifluoromethoxy) nicotinoyl)- 2-(4-cyclopropyl- 3-fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 258	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 10							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46491&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			692302	252627047							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79245	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)c(F)c3O)c3c2C(C1)N(C(=O)c1cnc(OC(F)(F)F)c(F)c1N)CC3	InChI=1S/C15H20N2O3/c1-11(2)16(12(3)4)15(18)9-8-13-6-5-7-14(10-13)17(19)20/h5-12H,1-4H3	DIVHLQIHPPWRRY-UHFFFAOYSA-N	46491	1-(5-(4-amino-5-fluoro- 6- (trifluoromethoxy) nicotinoyl)- 2-(4-cyclopropyl- 3-fluoro-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 258	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46491	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46491&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			692302	252627047							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79246	C=CC(=O)N1CCc2nn(-c3ccc(C4CC4)cc3O)c3c2C(C1)N(C(=O)c1ccc(C(F)(F)F)c(F)c1N)CC3	InChI=1S/C25H34N6O2/c1-19-22-18-27-31(21-8-5-4-6-9-21)25(33)24(22)20(2)30(19)12-7-10-23(32)26-11-13-29-16-14-28(3)15-17-29/h4-6,8-9,18H,7,10-17H2,1-3H3,(H,26,32)	VMDOUAQBNLDUDU-UHFFFAOYSA-N	46492	1-(5-(2-amino-3-fluoro- 4- (trifluoromethyl)benzoyl)- 2-(4-cyclopropyl-2- hydroxyphenyl)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 259	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 35							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46492	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46492&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			16193820	252627048							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79247	C=CC(=O)N1CC(OCC2=CCOCC2)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C13H7ClN2O2/c14-8-2-1-3-9(6-8)16-12(17)10-4-5-15-7-11(10)13(16)18/h1-7H	ZKUMGVLUSYTOMC-UHFFFAOYSA-N	46493	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclobutylphenyl)-9- ((3,6-dihydro-2H-pyran- 4-yl)methoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 260	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			<1.5							US Patent				aid1795887	US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46493&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1512454	252627049							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
79248	C=CC(=O)N1CC(OCC2=CCOCC2)c2nn(-c3ccc(C4CCC4)cc3)c3c2C(C1)N(C(=O)c1cnc(C(F)(F)F)cc1N)CC3	InChI=1S/C13H7ClN2O2/c14-8-2-1-3-9(6-8)16-12(17)10-4-5-15-7-11(10)13(16)18/h1-7H	ZKUMGVLUSYTOMC-UHFFFAOYSA-N	46493	1-(5-(4-amino-6- (trifluoromethyl) nicotinoyl)- 2-(4- cyclobutylphenyl)-9- ((3,6-dihydro-2H-pyran- 4-yl)methoxy)- 2,3,4,5,5a,6,8,9- octahydro-7H-1,2,5,7- tetraazabenzo[cd]azulen- 7-yl)prop-2-en-1-one::US20250346600, Compound 260	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN [2-1432]			 3.25							US Patent					US10106501	Argiriadi, MA; Breinlinger, EC; Cusack, KP; Hobson, AD; Potin, D; Barth, M; Amaudrut, J; Poupardin, O; Mounier, L; Kort, ME	10/23/2018	2/24/2019	Abbvie	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=46493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1464&target=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=46493&enzyme=Bifunctional+3%27-5%27+exonuclease%2FATP-dependent+helicase+WRN+%5B2-1432%5D&column=ki&startPg=0&Increment=50&submit=Search			1512454	252627049							1	SEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS	9QBV,9QBU,9OWD,9OWC,9OWB,9OWA,9OW9,9MK1,9MK0,9MJZ,9MJY,9MJX,9MJW,9MJV,9MJU,9MJT,9MJS,8YLE,7GQU,7GQT,7GQS,9RUS,9RUR,9RTI,8PFP,9OG8,9OG3,2FC0,2FBY,2FBX,2FBV,2FBT,2AXL,2E1F,2E1E,6TYV	Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	WRN_HUMAN	Q14191	A1KYY9