BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 119901 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NC(C)c2ccc(nc2)N2CCNCC2)n1 InChI=1S/C25H32N6O2S/c1-17(18-5-10-22(27-15-18)31-13-11-26-12-14-31)28-23(32)30-24-29-21(16-34-24)25(2,3)19-6-8-20(33-4)9-7-19/h5-10,15-17,26H,11-14H2,1-4H3,(H2,28,29,30,32) JWNGYFWRZVKHOW-UHFFFAOYSA-N 662074 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(1- (6-(piperazin-1- yl)pyridin-3- yl)ethyl)urea::US20240109853, Compound A001::US20240226094, Compound A001::US20250241908, Compound A001::US20250381196, Compound A001 Alpha-protein kinase 1 Homo sapiens 58.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662074 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662074&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 164517040 496710538 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119902 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NC(C)c2cc(F)c(cc2F)N2CCNCC2)n1 InChI=1S/C26H31F2N5O2S/c1-16(19-13-21(28)22(14-20(19)27)33-11-9-29-10-12-33)30-24(34)32-25-31-23(15-36-25)26(2,3)17-5-7-18(35-4)8-6-17/h5-8,13-16,29H,9-12H2,1-4H3,(H2,30,31,32,34) VZTBUUYKXBQHGT-UHFFFAOYSA-N 662076 1-(1-(2,5-difluoro-4- (piperazin-1- yl)phenyl)ethyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A002::US20240226094, Compound A002::US20250241908, Compound A002::US20250381196, Compound A002 Alpha-protein kinase 1 Homo sapiens 63.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662076 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662076&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407619 496710540 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119903 CC(NC(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1)c1cc(F)c(N2CCNCC2)c(F)c1 InChI=1S/C25H28BrF2N5OS/c1-15(16-12-19(27)22(20(28)13-16)33-10-8-29-9-11-33)30-23(34)32-24-31-21(14-35-24)25(2,3)17-4-6-18(26)7-5-17/h4-7,12-15,29H,8-11H2,1-3H3,(H2,30,31,32,34) SAEDLTJRRIMMDU-UHFFFAOYSA-N 662086 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(1- (3,5-difluoro-4- (piperazin-1- yl)phenyl)ethyl)urea::US20240109853, Compound A003::US20240226094, Compound A003::US20250241908, Compound A003::US20250381196, Compound A003 Alpha-protein kinase 1 Homo sapiens 45.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662086 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662086&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407635 496710548 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119904 CC(C)(c1csc(NC(=O)NCc2cncnc2)n1)c1ccc(Br)cc1 InChI=1S/C18H18BrN5OS/c1-18(2,13-3-5-14(19)6-4-13)15-10-26-17(23-15)24-16(25)22-9-12-7-20-11-21-8-12/h3-8,10-11H,9H2,1-2H3,(H2,22,23,24,25) GJMZCDRLEIMSCR-UHFFFAOYSA-N 662087 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3- (pyrimidin-5- ylmethyl)urea::US20240109853, Compound A004::US20240226094, Compound A004::US20250241908, Compound A004::US20250381196, Compound A004 Alpha-protein kinase 1 Homo sapiens 240 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662087 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662087&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407494 496710549 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119905 CC(C)(c1csc(NC(=O)NCc2cccc(c2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C24H28BrN5OS/c1-24(2,18-6-8-19(25)9-7-18)21-16-32-23(28-21)29-22(31)27-15-17-4-3-5-20(14-17)30-12-10-26-11-13-30/h3-9,14,16,26H,10-13,15H2,1-2H3,(H2,27,28,29,31) RKKMWADCUNGMGH-UHFFFAOYSA-N 662090 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A005::US20240226094, Compound A005::US20250241908, Compound A005::US20250381196, Compound A005 Alpha-protein kinase 1 Homo sapiens 97.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662090 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662090&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407691 496710552 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119906 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCC(CC2)C(N)=O)n1)c1ccc(Br)cc1 InChI=1S/C26H30BrN5O2S/c1-26(2,19-5-7-20(27)8-6-19)22-16-35-25(30-22)31-24(34)29-15-17-3-9-21(10-4-17)32-13-11-18(12-14-32)23(28)33/h3-10,16,18H,11-15H2,1-2H3,(H2,28,33)(H2,29,30,31,34) CBFHPNFFQSMFDO-UHFFFAOYSA-N 662093 1-(4-((3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2- yl)ureido)methyl)phenyl) piperidine-4- carboxamide::US20240109853, Compound A006::US20240226094, Compound A006::US20250241908, Compound A006::US20250381196, Compound A006 Alpha-protein kinase 1 Homo sapiens 104 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662093 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662093&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407703 496710555 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119907 COc3ccc(C(C)(C)c2csc(NC(=O)NCc1cncnc1)n2)cc3 InChI=1S/C19H21N5O2S/c1-19(2,14-4-6-15(26-3)7-5-14)16-11-27-18(23-16)24-17(25)22-10-13-8-20-12-21-9-13/h4-9,11-12H,10H2,1-3H3,(H2,22,23,24,25) BUEVYMRQCVJPJU-UHFFFAOYSA-N 662191 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3- (pyrimidin-5- ylmethyl)urea::US20240109853, Compound A104::US20250241908, Compound A104::US20250381196, Compound A104 Alpha-protein kinase 1 Homo sapiens 91.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662191&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119908 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)C(N)=O)n1)c1ccc(Br)cc1 InChI=1S/C21H21BrN4O2S/c1-21(2,15-7-9-16(22)10-8-15)17-12-29-20(25-17)26-19(28)24-11-13-3-5-14(6-4-13)18(23)27/h3-10,12H,11H2,1-2H3,(H2,23,27)(H2,24,25,26,28) IERFKBNCXQSTCV-UHFFFAOYSA-N 662095 4-((3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2- yl)ureido)methyl)benz- mide::US20240109853, Compound A008::US20240226094, Compound A008::US20250241908, Compound A008::US20250381196, Compound A008 Alpha-protein kinase 1 Homo sapiens 8.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662095 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662095&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407513 496710557 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119909 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCC(O)C2)n1)c1ccc(Br)cc1 InChI=1S/C24H27BrN4O2S/c1-24(2,17-5-7-18(25)8-6-17)21-15-32-23(27-21)28-22(31)26-13-16-3-9-19(10-4-16)29-12-11-20(30)14-29/h3-10,15,20,30H,11-14H2,1-2H3,(H2,26,27,28,31) NPORVNHMRRJHIQ-UHFFFAOYSA-N 662096 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-(3- hydroxypyrrolidin-1- yl)benzyl)urea::US20240109853, Compound A009::US20240226094, Compound A009::US20250241908, Compound A009::US20250381196, Compound A009 Alpha-protein kinase 1 Homo sapiens 154 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662096 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662096&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407614 496710558 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119910 CC(C)(c1csc(NC(=O)NCc2ccc(nc2)N2CCN(CCO)CC2)n1)c1ccc(Br)cc1 InChI=1S/C25H31BrN6O2S/c1-25(2,19-4-6-20(26)7-5-19)21-17-35-24(29-21)30-23(34)28-16-18-3-8-22(27-15-18)32-11-9-31(10-12-32)13-14-33/h3-8,15,17,33H,9-14,16H2,1-2H3,(H2,28,29,30,34) QLAUSAVSXWUZOC-UHFFFAOYSA-N 662097 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((6-(4- (2- hydroxyethyl)piperazin- 1-yl)pyridin-3- yl)methyl)urea::US20240109853, Compound A010::US20240226094, Compound A010::US20250241908, Compound A010::US20250381196, Compound A010 Alpha-protein kinase 1 Homo sapiens 200 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662097 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662097&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407572 496710559 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119911 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(nc2)N2CCC(C2)N(C)C)n1 InChI=1S/C26H34N6O2S/c1-26(2,19-7-9-21(34-5)10-8-19)22-17-35-25(29-22)30-24(33)28-15-18-6-11-23(27-14-18)32-13-12-20(16-32)31(3)4/h6-11,14,17,20H,12-13,15-16H2,1-5H3,(H2,28,29,30,33) DCPFLYNDRJZLCM-UHFFFAOYSA-N 662098 1-((6-(3- (dimethylamino)pyrrolidin- 1-yl)pyridin-3- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A011::US20240226094, Compound A011::US20250241908, Compound A011::US20250381196, Compound A011 Alpha-protein kinase 1 Homo sapiens 49.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662098 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662098&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407720 496710560 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119912 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2)N2CCC(C2)N(C)C)n1 InChI=1S/C25H33N7O2S/c1-25(2,18-6-8-20(34-5)9-7-18)21-16-35-24(29-21)30-23(33)28-14-17-12-26-22(27-13-17)32-11-10-19(15-32)31(3)4/h6-9,12-13,16,19H,10-11,14-15H2,1-5H3,(H2,28,29,30,33) CRWRVRHBWXWLHQ-UHFFFAOYSA-N 662099 1-((2-(3- (dimethylamino)pyrrolidin- 1-yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A012::US20240226094, Compound A012::US20250241908, Compound A012::US20250381196, Compound A012 Alpha-protein kinase 1 Homo sapiens 40.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662099 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662099&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407856 496710561 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119913 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCS(C)(=O)=O)n1 InChI=1S/C17H23N3O4S2/c1-17(2,12-5-7-13(24-3)8-6-12)14-11-25-16(19-14)20-15(21)18-9-10-26(4,22)23/h5-8,11H,9-10H2,1-4H3,(H2,18,19,20,21) UCXTVBUSEDEFRK-UHFFFAOYSA-N 662100 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(2- (methylsulfonyl)ethyl)urea::US20240109853, Compound A013::US20240226094, Compound A013::US20250241908, Compound A013::US20250381196, Compound A013 Alpha-protein kinase 1 Homo sapiens 316 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662100 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662100&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407561 496710562 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119914 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(NCCO)nc2)n1 InChI=1S/C22H27N5O3S/c1-22(2,16-5-7-17(30-3)8-6-16)18-14-31-21(26-18)27-20(29)25-13-15-4-9-19(24-12-15)23-10-11-28/h4-9,12,14,28H,10-11,13H2,1-3H3,(H,23,24)(H2,25,26,27,29) MNDYDDWPFWYQID-UHFFFAOYSA-N 662101 US20240109853, Compound A022::1-((6-((2- hydroxyethyl)amino)pyri- din-3-yl)methyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A014::US20240226094, Compound A022::US20250241908, Compound A022::US20250381196, Compound A022 Alpha-protein kinase 1 Homo sapiens 160 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662101&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169096279 496710563 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119915 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(nc2)C(=O)NC2CCN(C)CC2)n1 InChI=1S/C27H34N6O3S/c1-27(2,19-6-8-21(36-4)9-7-19)23-17-37-26(31-23)32-25(35)29-16-18-5-10-22(28-15-18)24(34)30-20-11-13-33(3)14-12-20/h5-10,15,17,20H,11-14,16H2,1-4H3,(H,30,34)(H2,29,31,32,35) AGXSEIODEVDACW-UHFFFAOYSA-N 662102 US20240109853, Compound A120::5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N-(1- methylpiperidin-4- yl)picolinamide::US20240109853, Compound A015::US20240226094, Compound A120::US20250241908, Compound A120::US20250381196, Compound A120 Alpha-protein kinase 1 Homo sapiens 24.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662102&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407600 496710564 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119916 CN1CCN(Cc2ccc(CNC(=O)Nc3nc(cs3)C(C)(C)c3ccc(Br)cc3)cc2)CC1 InChI=1S/C26H32BrN5OS/c1-26(2,21-8-10-22(27)11-9-21)23-18-34-25(29-23)30-24(33)28-16-19-4-6-20(7-5-19)17-32-14-12-31(3)13-15-32/h4-11,18H,12-17H2,1-3H3,(H2,28,29,30,33) FKTIJFPZBMPNOE-UHFFFAOYSA-N 662103 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-((4- methylpiperazin-1- yl)methyl)benzyl)urea::US20240109853, Compound A016::US20240226094, Compound A118::US20250241908, Compound A016::US20250381196, Compound A016 Alpha-protein kinase 1 Homo sapiens 27.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662103 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662103&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407730 496710565 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119917 CC(C)(c1csc(NC(=O)NCc2ccc(F)c(Cl)c2)n1)c1ccc(Br)cc1 InChI=1S/C20H18BrClFN3OS/c1-20(2,13-4-6-14(21)7-5-13)17-11-28-19(25-17)26-18(27)24-10-12-3-8-16(23)15(22)9-12/h3-9,11H,10H2,1-2H3,(H2,24,25,26,27) RWSSJADOSLXLPJ-UHFFFAOYSA-N 662104 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- chloro-4- fluorobenzyl)urea::US20240109853, Compound A017::US20240226094, Compound A017::US20250241908, Compound A017::US20250381196, Compound A017 Alpha-protein kinase 1 Homo sapiens 204 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662104 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662104&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407829 496710566 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119918 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)C(=O)NC2CCN(C)CC2)n1 InChI=1S/C28H35N5O3S/c1-28(2,21-9-11-23(36-4)12-10-21)24-18-37-27(31-24)32-26(35)29-17-19-5-7-20(8-6-19)25(34)30-22-13-15-33(3)16-14-22/h5-12,18,22H,13-17H2,1-4H3,(H,30,34)(H2,29,31,32,35) YWUUYNPJOQLWOM-UHFFFAOYSA-N 662105 4-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N-(1- methylpiperidin-4- yl)benzamide::US20240109853, Compound A018::US20240226094, Compound A018::US20250241908, Compound A018::US20250381196, Compound A018 Alpha-protein kinase 1 Homo sapiens 29.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662105 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662105&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407650 496710567 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119919 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(NC3CCN(C)CC3)nc2)n1 InChI=1S/C26H34N6O2S/c1-26(2,19-6-8-21(34-4)9-7-19)22-17-35-25(30-22)31-24(33)28-16-18-5-10-23(27-15-18)29-20-11-13-32(3)14-12-20/h5-10,15,17,20H,11-14,16H2,1-4H3,(H,27,29)(H2,28,30,31,33) AHSBYNQZDLYVHL-UHFFFAOYSA-N 662106 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-((6- ((1-methylpiperidin-4- yl)amino)pyridin-3- yl)methyl)urea::US20240109853, Compound A019::US20240226094, Compound A019::US20250241908, Compound A019::US20250381196, Compound A019 Alpha-protein kinase 1 Homo sapiens 32.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662106 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662106&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407430 496710568 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119920 CC(C)(c1csc(NC(=O)NCCF)n1)c1ccc(Br)cc1 InChI=1S/C15H17BrFN3OS/c1-15(2,10-3-5-11(16)6-4-10)12-9-22-14(19-12)20-13(21)18-8-7-17/h3-6,9H,7-8H2,1-2H3,(H2,18,19,20,21) LEYOSLMQYOMTAQ-UHFFFAOYSA-N 662107 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(2- fluoroethyl)urea::US20240109853, Compound A020::US20240226094, Compound A020::US20250241908, Compound A020::US20250381196, Compound A020 Alpha-protein kinase 1 Homo sapiens 144 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662107 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662107&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407375 496710569 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119921 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCF)n1 InChI=1S/C16H20FN3O2S/c1-16(2,11-4-6-12(22-3)7-5-11)13-10-23-15(19-13)20-14(21)18-9-8-17/h4-7,10H,8-9H2,1-3H3,(H2,18,19,20,21) PTVUATSWCUXATG-UHFFFAOYSA-N 662108 1-(2-fluoroethyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A021::US20240226094, Compound A021::US20250241908, Compound A021::US20250381196, Compound A021 Alpha-protein kinase 1 Homo sapiens 104 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662108 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662108&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407778 496710570 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119922 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(NCCO)nc2)n1 InChI=1S/C22H27N5O3S/c1-22(2,16-5-7-17(30-3)8-6-16)18-14-31-21(26-18)27-20(29)25-13-15-4-9-19(24-12-15)23-10-11-28/h4-9,12,14,28H,10-11,13H2,1-3H3,(H,23,24)(H2,25,26,27,29) MNDYDDWPFWYQID-UHFFFAOYSA-N 662101 US20240109853, Compound A022::1-((6-((2- hydroxyethyl)amino)pyri- din-3-yl)methyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A014::US20240226094, Compound A022::US20250241908, Compound A022::US20250381196, Compound A022 Alpha-protein kinase 1 Homo sapiens 232 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662101 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662101&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169096279 496710563 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119923 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(nc2)N(C)CCO)n1 InChI=1S/C23H29N5O3S/c1-23(2,17-6-8-18(31-4)9-7-17)19-15-32-22(26-19)27-21(30)25-14-16-5-10-20(24-13-16)28(3)11-12-29/h5-10,13,15,29H,11-12,14H2,1-4H3,(H2,25,26,27,30) GXBSMRGZLJBEOL-UHFFFAOYSA-N 662110 1-((6-((2- hydroxyethyl)(methyl)a- mino)pyridin-3- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A023::US20240226094, Compound A023::US20250241908, Compound A023::US20250381196, Compound A023 Alpha-protein kinase 1 Homo sapiens 229 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662110 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662110&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407684 496710571 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119924 CC(C#C)(c1csc(NC(=O)NCCC#N)n1)c1ccc(Cl)cc1 InChI=1S/C17H15ClN4OS/c1-3-17(2,12-5-7-13(18)8-6-12)14-11-24-16(21-14)22-15(23)20-10-4-9-19/h1,5-8,11H,4,10H2,2H3,(H2,20,21,22,23) VKBREIDYVCEFMR-UHFFFAOYSA-N 662111 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- cyanoethyl)urea::US20240109853, Compound A024::US20240226094, Compound A024::US20250241908, Compound A024::US20250381196, Compound A024 Alpha-protein kinase 1 Homo sapiens 13.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662111 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662111&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407859 496710572 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119925 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1)c1ccc(cc1)C1CC1 InChI=1S/C27H33N5OS/c1-27(2,22-9-7-21(8-10-22)20-5-6-20)24-18-34-26(30-24)31-25(33)29-17-19-3-11-23(12-4-19)32-15-13-28-14-16-32/h3-4,7-12,18,20,28H,5-6,13-17H2,1-2H3,(H2,29,30,31,33) ZUWMPJKJDOSAKN-UHFFFAOYSA-N 662112 1-(4-(2-(4- cyclopropylphenyl)propan- 2-yl)thiazol-2-yl)-3- (4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A025::US20240226094, Compound A025::US20250241908, Compound A025::US20250381196, Compound A025 Alpha-protein kinase 1 Homo sapiens 334 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662112 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662112&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221893 496710573 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119926 CC(C)(c1csc(NC(=O)NCc2ccc(CN3CCNCC3)cc2)n1)c1ccc(Br)cc1 InChI=1S/C25H30BrN5OS/c1-25(2,20-7-9-21(26)10-8-20)22-17-33-24(29-22)30-23(32)28-15-18-3-5-19(6-4-18)16-31-13-11-27-12-14-31/h3-10,17,27H,11-16H2,1-2H3,(H2,28,29,30,32) ZEMLUZKEMFDZEK-UHFFFAOYSA-N 684607 1-(4-(2-(4- bromophenyl)propan- 2-yl)thiazol-2-yl)-3- (4-(piperazin-1- ylmethyl)benzyl)urea::US20240226094, Compound A026::US20250241908, Compound A026::US20250381196, Compound A026 Alpha-protein kinase 1 Homo sapiens 117 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=684607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=684607&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407733 503273980 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119927 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C24H28BrN5OS/c1-24(2,18-5-7-19(25)8-6-18)21-16-32-23(28-21)29-22(31)27-15-17-3-9-20(10-4-17)30-13-11-26-12-14-30/h3-10,16,26H,11-15H2,1-2H3,(H2,27,28,29,31) JJHJLCZSVXMILF-UHFFFAOYSA-N 662114 1-(4-(2-(4- bromophenyl)propan--2 yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A027::US20240226094, Compound A027::US20250241908, Compound A027::US20250381196, Compound A027 Alpha-protein kinase 1 Homo sapiens 46.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662114 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662114&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407862 496710575 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119928 CC(C)(c1csc(NC(=O)NCCCCN)n1)c1ccc(Br)cc1 InChI=1S/C17H23BrN4OS/c1-17(2,12-5-7-13(18)8-6-12)14-11-24-16(21-14)22-15(23)20-10-4-3-9-19/h5-8,11H,3-4,9-10,19H2,1-2H3,(H2,20,21,22,23) UDANQLAXERUDGJ-UHFFFAOYSA-N 662115 1-(4-aminobutyl)-3-(4- (2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A028::US20240226094, Compound A028::US20250241908, Compound A028::US20250381196, Compound A028 Alpha-protein kinase 1 Homo sapiens 53.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662115 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662115&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407542 496710576 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119929 CC1CNCCN1c1ccc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)cc1 InChI=1S/C25H30BrN5OS/c1-17-14-27-12-13-31(17)21-10-4-18(5-11-21)15-28-23(32)30-24-29-22(16-33-24)25(2,3)19-6-8-20(26)9-7-19/h4-11,16-17,27H,12-15H2,1-3H3,(H2,28,29,30,32) ISKPWFSKVJWZTL-UHFFFAOYSA-N 662116 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-(2- methylpiperazin-1- yl)benzyl)urea::US20240109853, Compound A029::US20240226094, Compound A029::US20250241908, Compound A029::US20250381196, Compound A029 Alpha-protein kinase 1 Homo sapiens 73.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662116 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662116&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407662 496710577 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119930 Cc1sc(NC(=O)NCc2ccc(cc2)N2CCNCC2)nc1C(C)(C)c1ccc(Br)cc1 InChI=1S/C25H30BrN5OS/c1-17-22(25(2,3)19-6-8-20(26)9-7-19)29-24(33-17)30-23(32)28-16-18-4-10-21(11-5-18)31-14-12-27-13-15-31/h4-11,27H,12-16H2,1-3H3,(H2,28,29,30,32) BIUQYTPIXZBIEH-UHFFFAOYSA-N 662117 1-(4-(2-(4- bromophenyl)propan-2- yl)-5-methylthiazol-2- yl)-3-(4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A030::US20240226094, Compound A030::US20250241908, Compound A030::US20250381196, Compound A030 Alpha-protein kinase 1 Homo sapiens 232 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662117 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662117&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407391 496710578 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119931 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)c(F)c1 InChI=1S/C24H27ClFN5OS/c1-24(2,17-5-8-19(25)20(26)13-17)21-15-33-23(29-21)30-22(32)28-14-16-3-6-18(7-4-16)31-11-9-27-10-12-31/h3-8,13,15,27H,9-12,14H2,1-2H3,(H2,28,29,30,32) KMJRVGZUJLQBBL-UHFFFAOYSA-N 662118 1-(4-(2-(4-chloro-3- fluorophenyl)propan-2- yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A031::US20240226094, Compound A031::US20250241908, Compound A031::US20250381196, Compound A031 Alpha-protein kinase 1 Homo sapiens 345 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662118 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662118&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407774 496710579 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119932 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCC(N)C2)n1)c1ccc(Br)cc1 InChI=1S/C24H28BrN5OS/c1-24(2,17-5-7-18(25)8-6-17)21-15-32-23(28-21)29-22(31)27-13-16-3-9-20(10-4-16)30-12-11-19(26)14-30/h3-10,15,19H,11-14,26H2,1-2H3,(H2,27,28,29,31) WXLUQYIQUKIZKU-UHFFFAOYSA-N 662119 1-(4-(3- aminopyrrolidin-1- yl)benzyl)-3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A032::US20240226094, Compound A032::US20250241908, Compound A032::US20250381196, Compound A032 Alpha-protein kinase 1 Homo sapiens 291 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662119 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662119&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407702 496710580 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119933 CC(C)(c1csc(NC(=O)NCc2ccc(OCC(=O)N3CCNCC3)cc2)n1)c1ccc(Br)cc1 InChI=1S/C26H30BrN5O3S/c1-26(2,19-5-7-20(27)8-6-19)22-17-36-25(30-22)31-24(34)29-15-18-3-9-21(10-4-18)35-16-23(33)32-13-11-28-12-14-32/h3-10,17,28H,11-16H2,1-2H3,(H2,29,30,31,34) RZYMUZAXHHGSJS-UHFFFAOYSA-N 662120 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-(2- oxo-2-(piperazin-1- yl)ethoxy)benzyl)urea::US20240109853, Compound A033::US20240226094, Compound A033::US20250241908, Compound A033::US20250381196, Compound A033 Alpha-protein kinase 1 Homo sapiens 80.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662120 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662120&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407390 496710581 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119934 CC(C)(c1csc(NC(=O)NCc2ccc(OCCN3CCNCC3)cc2)n1)c1ccc(Br)cc1 InChI=1S/C26H32BrN5O2S/c1-26(2,20-5-7-21(27)8-6-20)23-18-35-25(30-23)31-24(33)29-17-19-3-9-22(10-4-19)34-16-15-32-13-11-28-12-14-32/h3-10,18,28H,11-17H2,1-2H3,(H2,29,30,31,33) WKAWNUBPQLBKIT-UHFFFAOYSA-N 662121 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-(2- (piperazin-1- yl)ethoxy)benzyl)urea::US20240109853, Compound A034::US20240226094, Compound A034::US20250241908, Compound A034::US20250381196, Compound A034 Alpha-protein kinase 1 Homo sapiens 114 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662121&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407793 496710582 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119935 CC(C)(c1csc(NC(=O)NCc2ccc(OCCCN3CCNCC3)cc2)n1)c1ccc(Br)cc1 InChI=1S/C27H34BrN5O2S/c1-27(2,21-6-8-22(28)9-7-21)24-19-36-26(31-24)32-25(34)30-18-20-4-10-23(11-5-20)35-17-3-14-33-15-12-29-13-16-33/h4-11,19,29H,3,12-18H2,1-2H3,(H2,30,31,32,34) COLHJMXFXXUIOT-UHFFFAOYSA-N 662122 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-(3- (piperazin-1- yl)propoxy)benzyl)urea::US20240109853, Compound A035::US20240226094, Compound A035::US20250241908, Compound A035::US20250381196, Compound A035 Alpha-protein kinase 1 Homo sapiens 52.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662122 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662122&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407567 496710583 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119936 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(N3CCNCC3)c(F)c2)n1 InChI=1S/C24H29FN6O2S/c1-24(2,17-4-6-18(33-3)7-5-17)20-15-34-23(29-20)30-22(32)28-14-16-12-19(25)21(27-13-16)31-10-8-26-9-11-31/h4-7,12-13,15,26H,8-11,14H2,1-3H3,(H2,28,29,30,32) CHLCVEKSBRKROL-UHFFFAOYSA-N 662123 1-((5-fluoro-6- (piperazin-1-yl)pyridin- 3-yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A036::US20240226094, Compound A036::US20250241908, Compound A036::US20250381196, Compound A036 Alpha-protein kinase 1 Homo sapiens 24.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662123 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662123&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407860 496710584 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119937 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(CN3CCNCC3)c(F)c2)n1 InChI=1S/C26H32FN5O2S/c1-26(2,20-6-8-21(34-3)9-7-20)23-17-35-25(30-23)31-24(33)29-15-18-4-5-19(22(27)14-18)16-32-12-10-28-11-13-32/h4-9,14,17,28H,10-13,15-16H2,1-3H3,(H2,29,30,31,33) BEQXASWRJSDZGJ-UHFFFAOYSA-N 662124 1-(3-fluoro-4- (piperazin-1- ylmethyl)benzyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A037::US20240226094, Compound A037::US20250241908, Compound A037::US20250381196, Compound A037 Alpha-protein kinase 1 Homo sapiens 57.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662124 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662124&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407580 496710585 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119938 CC(C)(c1csc(NC(=O)NCc2cnc(N3CCNCC3)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C23H26BrFN6OS/c1-23(2,16-3-5-17(24)6-4-16)19-14-33-22(29-19)30-21(32)28-13-15-11-18(25)20(27-12-15)31-9-7-26-8-10-31/h3-6,11-12,14,26H,7-10,13H2,1-2H3,(H2,28,29,30,32) URYBPDZOPMFRCC-UHFFFAOYSA-N 662125 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((5- fluoro-6-(piperazin-1- yl)pyridin-3- yl)methyl)urea::US20240109853, Compound A038::US20240226094, Compound A038::US20250241908, Compound A038::US20250381196, Compound A038 Alpha-protein kinase 1 Homo sapiens 30.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662125 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662125&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407692 496710586 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119939 CCC(C)(c1ccc(OC)cc1)c1csc(NC(=O)NCc2ccc(N3CCNCC3)cc2)n1 InChI=1S/C26H33N5O2S/c1-4-26(2,20-7-11-22(33-3)12-8-20)23-18-34-25(29-23)30-24(32)28-17-19-5-9-21(10-6-19)31-15-13-27-14-16-31/h5-12,18,27H,4,13-17H2,1-3H3,(H2,28,29,30,32) VCHUNUKGJKNIBI-UHFFFAOYSA-N 75450 1-(4-(2-(4- bromophenyl)butan-2- yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20250381196, Compound A039 Alpha-protein kinase 1 Homo sapiens 189 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75450 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75450&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 665657 252652658 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119940 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cc(F)c(N3CCNCC3)c(F)c2)n1 InChI=1S/C25H29F2N5O2S/c1-25(2,17-4-6-18(34-3)7-5-17)21-15-35-24(30-21)31-23(33)29-14-16-12-19(26)22(20(27)13-16)32-10-8-28-9-11-32/h4-7,12-13,15,28H,8-11,14H2,1-3H3,(H2,29,30,31,33) RHCBARHDKBBVLT-UHFFFAOYSA-N 662127 1-(3,5-difluoro-4- (piperazin-1-yl)benzyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A040::US20240226094, Compound A040::US20250241908, Compound A040::US20250381196, Compound A040 Alpha-protein kinase 1 Homo sapiens 45.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662127 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662127&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407830 496710588 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119941 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(NC3CCNCC3)cc2)n1 InChI=1S/C26H33N5O2S/c1-26(2,19-6-10-22(33-3)11-7-19)23-17-34-25(30-23)31-24(32)28-16-18-4-8-20(9-5-18)29-21-12-14-27-15-13-21/h4-11,17,21,27,29H,12-16H2,1-3H3,(H2,28,30,31,32) GYMXNXYAUSTLFZ-UHFFFAOYSA-N 662128 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(4- (piperidin-4- ylamino)benzyl)urea::US20240109853, Compound A041::US20240226094, Compound A041::US20250241908, Compound A041::US20250381196, Compound A041 Alpha-protein kinase 1 Homo sapiens 23.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662128 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662128&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407543 496710589 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119942 COc4ccc(C(C)(C)c3csc(NC(=O)NCc2ccc(C(=O)NC1CCNCC1)cc2)n3)cc4 InChI=1S/C27H33N5O3S/c1-27(2,20-8-10-22(35-3)11-9-20)23-17-36-26(31-23)32-25(34)29-16-18-4-6-19(7-5-18)24(33)30-21-12-14-28-15-13-21/h4-11,17,21,28H,12-16H2,1-3H3,(H,30,33)(H2,29,31,32,34) DQBGDZNKUIERDE-UHFFFAOYSA-N 761061 4-((3-(4-(2-(4-methoxy- phenyl)propan-2-yl)thiazol- 2-yl)ureido)methyl)-N- (piperidin-4-yl)benzamide::US20250241908, Compound A042::US20250381196, Compound A042 Alpha-protein kinase 1 Homo sapiens 15.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=761061 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=761061&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407451 520671328 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119943 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cccc(n2)N2CCNCC2)n1 InChI=1S/C24H30N6O2S/c1-24(2,17-7-9-19(32-3)10-8-17)20-16-33-23(28-20)29-22(31)26-15-18-5-4-6-21(27-18)30-13-11-25-12-14-30/h4-10,16,25H,11-15H2,1-3H3,(H2,26,28,29,31) GROIMMHGFBRVFJ-UHFFFAOYSA-N 662130 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-((6- (piperazin-1-yl)pyridin- 2-yl)methyl)urea::US20240109853, Compound A043::US20240226094, Compound A043::US20250241908, Compound A043::US20250381196, Compound A043 Alpha-protein kinase 1 Homo sapiens 165 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662130 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662130&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407715 496710591 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119944 CC(c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C23H26BrN5OS/c1-16(18-4-6-19(24)7-5-18)21-15-31-23(27-21)28-22(30)26-14-17-2-8-20(9-3-17)29-12-10-25-11-13-29/h2-9,15-16,25H,10-14H2,1H3,(H2,26,27,28,30) GSQYRVOFROMDQO-UHFFFAOYSA-N 662131 1-(4-(1-(4- bromophenyl)ethyl)thiazol- 2-yl)-3-(4-(piperazin- 1-yl)benzyl)urea::US20240109853, Compound A044::US20240226094, Compound A044::US20250241908, Compound A044::US20250381196, Compound A044 Alpha-protein kinase 1 Homo sapiens 147 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662131 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662131&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407780 496710592 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119945 Brc1ccc(cc1)C1(CCCC1)c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1 InChI=1S/C26H30BrN5OS/c27-21-7-5-20(6-8-21)26(11-1-2-12-26)23-18-34-25(30-23)31-24(33)29-17-19-3-9-22(10-4-19)32-15-13-28-14-16-32/h3-10,18,28H,1-2,11-17H2,(H2,29,30,31,33) UBTPPMWNCTUGGR-UHFFFAOYSA-N 662132 1-(4-(1-(4- bromophenyl)cyclopentyl) thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A045::US20240226094, Compound A045::US20250241908, Compound A045::US20250381196, Compound A045 Alpha-protein kinase 1 Homo sapiens 24.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662132 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662132&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407846 496710593 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119946 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C24H28ClN5OS/c1-24(2,18-5-7-19(25)8-6-18)21-16-32-23(28-21)29-22(31)27-15-17-3-9-20(10-4-17)30-13-11-26-12-14-30/h3-10,16,26H,11-15H2,1-2H3,(H2,27,28,29,31) PTNOBHRJTPOSJV-UHFFFAOYSA-N 662133 1-(4-(2-(4- chlorophenyl)propan-2- yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A046::US20240226094, Compound A046::US20250241908, Compound A046::US20250381196, Compound A046 Alpha-protein kinase 1 Homo sapiens 79.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662133 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662133&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407570 496710594 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119947 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1)c1ccc(F)cc1 InChI=1S/C24H28FN5OS/c1-24(2,18-5-7-19(25)8-6-18)21-16-32-23(28-21)29-22(31)27-15-17-3-9-20(10-4-17)30-13-11-26-12-14-30/h3-10,16,26H,11-15H2,1-2H3,(H2,27,28,29,31) QIZFQFXFFAJPJQ-UHFFFAOYSA-N 662134 1-(4-(2-(4- fluorophenyl)propan-2- yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A047::US20240226094, Compound A047::US20250241908, Compound A047::US20250381196, Compound A047 Alpha-protein kinase 1 Homo sapiens 167 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662134 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662134&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407616 496710595 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119948 CC(C)(c1csc(NC(=O)NCc2ccc(cc2Cl)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C24H27BrClN5OS/c1-24(2,17-4-6-18(25)7-5-17)21-15-33-23(29-21)30-22(32)28-14-16-3-8-19(13-20(16)26)31-11-9-27-10-12-31/h3-8,13,15,27H,9-12,14H2,1-2H3,(H2,28,29,30,32) NRSHNUCUHVSOLH-UHFFFAOYSA-N 662135 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(2- chloro-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A048::US20240226094, Compound A048::US20250241908, Compound A048::US20250381196, Compound A048 Alpha-protein kinase 1 Homo sapiens 138 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662135 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662135&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407664 496710596 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119949 CC(C)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(c2)C(F)(F)F)n1)c1ccc(Br)cc1 InChI=1S/C25H27BrF3N5OS/c1-24(2,17-4-6-18(26)7-5-17)21-15-36-23(32-21)33-22(35)31-14-16-3-8-20(19(13-16)25(27,28)29)34-11-9-30-10-12-34/h3-8,13,15,30H,9-12,14H2,1-2H3,(H2,31,32,33,35) AMZPRGNUXHECKM-UHFFFAOYSA-N 662136 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4- (piperazin-1-yl)-3- (trifluoromethyl)benzyl) urea::US20240109853, Compound A049::US20250241908, Compound A049::US20250381196, Compound A049 Alpha-protein kinase 1 Homo sapiens 119 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662136 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662136&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407562 496710597 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119950 CC(C)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C24H27BrFN5OS/c1-24(2,17-4-6-18(25)7-5-17)21-15-33-23(29-21)30-22(32)28-14-16-3-8-20(19(26)13-16)31-11-9-27-10-12-31/h3-8,13,15,27H,9-12,14H2,1-2H3,(H2,28,29,30,32) WMVZQLICNYAJPT-UHFFFAOYSA-N 662137 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- fluoro-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A050::US20240226094, Compound A050::US20250241908, Compound A050::US20250381196, Compound A050 Alpha-protein kinase 1 Homo sapiens 26.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662137 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662137&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407539 496710598 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119951 Cc1cc(ccc1CNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1)N1CCNCC1 InChI=1S/C25H30BrN5OS/c1-17-14-21(31-12-10-27-11-13-31)9-4-18(17)15-28-23(32)30-24-29-22(16-33-24)25(2,3)19-5-7-20(26)8-6-19/h4-9,14,16,27H,10-13,15H2,1-3H3,(H2,28,29,30,32) PXHJKNNQJCEWFW-UHFFFAOYSA-N 662138 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(2- methyl-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A051::US20240226094, Compound A051::US20250241908, Compound A051::US20250381196, Compound A051 Alpha-protein kinase 1 Homo sapiens 125 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662138 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662138&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407748 496710599 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119952 CC(C)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(c2)C(N)=O)n1)c1ccc(Br)cc1 InChI=1S/C25H29BrN6O2S/c1-25(2,17-4-6-18(26)7-5-17)21-15-35-24(30-21)31-23(34)29-14-16-3-8-20(19(13-16)22(27)33)32-11-9-28-10-12-32/h3-8,13,15,28H,9-12,14H2,1-2H3,(H2,27,33)(H2,29,30,31,34) YGDWAIVDRWUKGH-UHFFFAOYSA-N 662139 5-((3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2- yl)ureido)methyl)-2- (piperazin-1- yl)benzamide::US20240109853, Compound A052::US20240226094, Compound A052::US20250241908, Compound A052::US20250381196, Compound A052 Alpha-protein kinase 1 Homo sapiens 24.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662139 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662139&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407455 496710600 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119953 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1 InChI=1S/C25H31N5O2S/c1-25(2,19-6-10-21(32-3)11-7-19)22-17-33-24(28-22)29-23(31)27-16-18-4-8-20(9-5-18)30-14-12-26-13-15-30/h4-11,17,26H,12-16H2,1-3H3,(H2,27,28,29,31) YSBZRHSSFCZBFW-UHFFFAOYSA-N 662140 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A053::US20250241908, Compound A053::US20250381196, Compound A053 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662140 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662140&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407817 496710601 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119954 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(F)c2)n1 InChI=1S/C25H30FN5O2S/c1-25(2,18-5-7-19(33-3)8-6-18)22-16-34-24(29-22)30-23(32)28-15-17-4-9-21(20(26)14-17)31-12-10-27-11-13-31/h4-9,14,16,27H,10-13,15H2,1-3H3,(H2,28,29,30,32) XMPOFGLVOCOQSF-UHFFFAOYSA-N 662141 US20240109853, Compound A054::1-(3-fluoro-4- (piperazin-1-yl)benzyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::BDBM684638::US20250241908, Compound A054::US20250381196, Compound A054 Alpha-protein kinase 1 Homo sapiens 30.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662141 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662141&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407467 496710602 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119955 COCCOc1cc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)ccc1N1CCNCC1 InChI=1S/C27H34BrN5O3S/c1-27(2,20-5-7-21(28)8-6-20)24-18-37-26(31-24)32-25(34)30-17-19-4-9-22(33-12-10-29-11-13-33)23(16-19)36-15-14-35-3/h4-9,16,18,29H,10-15,17H2,1-3H3,(H2,30,31,32,34) NVBMOMQAFRQHSS-UHFFFAOYSA-N 662142 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3-(2- methoxyethoxy)-4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A055::US20240226094, Compound A055::US20250241908, Compound A055::US20250381196, Compound A055 Alpha-protein kinase 1 Homo sapiens 182 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662142 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662142&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407444 496710603 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119956 CC(O)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C23H25BrFN5O2S/c1-23(32,16-3-5-17(24)6-4-16)20-14-33-22(28-20)29-21(31)27-13-15-2-7-19(18(25)12-15)30-10-8-26-9-11-30/h2-7,12,14,26,32H,8-11,13H2,1H3,(H2,27,28,29,31) OZBGJQQOQSXANG-UHFFFAOYSA-N 662143 1-(4-(1-(4- bromophenyl)-1- hydroxyethyl)thiazol-2- yl)-3-(3-fluoro-4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A056::US20240226094, Compound A056::US20250241908, Compound A056::US20250381196, Compound A056 Alpha-protein kinase 1 Homo sapiens 176 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662143&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407410 496710604 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119957 CC(C)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(F)c2)n1)c1ccc(Br)cn1 InChI=1S/C23H26BrFN6OS/c1-23(2,19-6-4-16(24)13-27-19)20-14-33-22(29-20)30-21(32)28-12-15-3-5-18(17(25)11-15)31-9-7-26-8-10-31/h3-6,11,13-14,26H,7-10,12H2,1-2H3,(H2,28,29,30,32) UUTBYATVGGWWLW-UHFFFAOYSA-N 662144 1-(4-(2-(5- bromopyridin-2- yl)propan-2-yl)thiazol- 2-yl)-3-(3-fluoro-4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A057::US20240226094, Compound A057::US20250241908, Compound A057::US20250381196, Compound A057 Alpha-protein kinase 1 Homo sapiens 246 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662144&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407732 496710605 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119958 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(CO)c2)n1 InChI=1S/C26H33N5O3S/c1-26(2,20-5-7-21(34-3)8-6-20)23-17-35-25(29-23)30-24(33)28-15-18-4-9-22(19(14-18)16-32)31-12-10-27-11-13-31/h4-9,14,17,27,32H,10-13,15-16H2,1-3H3,(H2,28,29,30,33) WDEBKWPPCWWFLI-UHFFFAOYSA-N 662145 1-(3-(hydroxymethyl)-4- (piperazin-1-yl)benzyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A058::US20240226094, Compound A058::US20250241908, Compound A058::US20250381196, Compound A058 Alpha-protein kinase 1 Homo sapiens 130 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662145&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407751 496710606 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119959 CCOc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1 InChI=1S/C26H33N5O2S/c1-4-33-22-11-7-20(8-12-22)26(2,3)23-18-34-25(29-23)30-24(32)28-17-19-5-9-21(10-6-19)31-15-13-27-14-16-31/h5-12,18,27H,4,13-17H2,1-3H3,(H2,28,29,30,32) HXDPLIPGZJQLRH-UHFFFAOYSA-N 662146 1-(4-(2-(4- ethoxyphenyl)propan-2- yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A059::US20240226094, Compound A059::US20250241908, Compound A059::US20250381196, Compound A059 Alpha-protein kinase 1 Homo sapiens 269 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662146&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407781 496710607 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119960 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(c2)C(N)=O)n1 InChI=1S/C26H32N6O3S/c1-26(2,18-5-7-19(35-3)8-6-18)22-16-36-25(30-22)31-24(34)29-15-17-4-9-21(20(14-17)23(27)33)32-12-10-28-11-13-32/h4-9,14,16,28H,10-13,15H2,1-3H3,(H2,27,33)(H2,29,30,31,34) DAEJIHRHHVLUOF-UHFFFAOYSA-N 662147 5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-2- (piperazin-1- yl)benzamide::US20240109853, Compound A060::US20240226094, Compound A060::US20250241908, Compound A060::US20250381196, Compound A060 Alpha-protein kinase 1 Homo sapiens 8.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662147&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407550 496710608 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119961 CC(C)(c1csc(NC(=O)NCCCN)n1)c1ccc(Br)cc1 InChI=1S/C16H21BrN4OS/c1-16(2,11-4-6-12(17)7-5-11)13-10-23-15(20-13)21-14(22)19-9-3-8-18/h4-7,10H,3,8-9,18H2,1-2H3,(H2,19,20,21,22) WUTFXLKKPRRJLT-UHFFFAOYSA-N 662148 1-(3-aminopropyl)-3-(4- (2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A061::US20240226094, Compound A061::US20250241908, Compound A061::US20250381196, Compound A061 Alpha-protein kinase 1 Homo sapiens 195 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662148&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407472 496710609 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119962 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)N2CC3CC2CN3)n1 InChI=1S/C26H31N5O2S/c1-26(2,18-6-10-22(33-3)11-7-18)23-16-34-25(29-23)30-24(32)28-13-17-4-8-20(9-5-17)31-15-19-12-21(31)14-27-19/h4-11,16,19,21,27H,12-15H2,1-3H3,(H2,28,29,30,32) TXXHNHMNZPQKRR-UHFFFAOYSA-N 662149 1-(4-(2,5- diazabicyclo[2.2.1]heptan- 2-yl)benzyl)-3-(4-(2- (4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A062::US20240226094, Compound A062::US20250241908, Compound A062::US20250381196, Compound A062 Alpha-protein kinase 1 Homo sapiens 60.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662149&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407804 496710610 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119963 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(N3CCNC(C)C3)c(c2)C(N)=O)n1 InChI=1S/C27H34N6O3S/c1-17-15-33(12-11-29-17)22-10-5-18(13-21(22)24(28)34)14-30-25(35)32-26-31-23(16-37-26)27(2,3)19-6-8-20(36-4)9-7-19/h5-10,13,16-17,29H,11-12,14-15H2,1-4H3,(H2,28,34)(H2,30,31,32,35) KFLNYNOWBXWCBJ-UHFFFAOYSA-N 662150 5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-2-(3- methylpiperazin-1- yl)benzamide::US20240109853, Compound A063::US20240226094, Compound A063::US20250241908, Compound A063::US20250381196, Compound A063 Alpha-protein kinase 1 Homo sapiens 29.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662150 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662150&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221905 496710611 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119964 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(N3CC4CC3CN4)c(c2)C(N)=O)n1 InChI=1S/C27H32N6O3S/c1-27(2,17-5-7-20(36-3)8-6-17)23-15-37-26(31-23)32-25(35)30-12-16-4-9-22(21(10-16)24(28)34)33-14-18-11-19(33)13-29-18/h4-10,15,18-19,29H,11-14H2,1-3H3,(H2,28,34)(H2,30,31,32,35) ATFCCSXXVGNOFB-UHFFFAOYSA-N 662151 2-(2,5- diazabicyclo[2.2.1]heptan- 2-yl)-5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)benza- mide::US20240109853, Compound A064::US20240226094, Compound A064::US20250241908, Compound A064::US20250381196, Compound A064 Alpha-protein kinase 1 Homo sapiens 41.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662151&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407835 496710612 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119965 CNC(=O)c1cc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(OC)cc2)ccc1N1CCNCC1 InChI=1S/C27H34N6O3S/c1-27(2,19-6-8-20(36-4)9-7-19)23-17-37-26(31-23)32-25(35)30-16-18-5-10-22(21(15-18)24(34)28-3)33-13-11-29-12-14-33/h5-10,15,17,29H,11-14,16H2,1-4H3,(H,28,34)(H2,30,31,32,35) BUQDEDSLJVQECZ-UHFFFAOYSA-N 662152 5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N- methyl-2-(piperazin-1- yl)benzamide::US20240109853, Compound A065::US20240226094, Compound A065::US20250241908, Compound A065::US20250381196, Compound A065 Alpha-protein kinase 1 Homo sapiens 30.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662152&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407819 496710613 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119966 CC(C)(c1csc(NC(=O)NCCS(C)(=O)=O)n1)c1ccc(Br)cc1 InChI=1S/C16H20BrN3O3S2/c1-16(2,11-4-6-12(17)7-5-11)13-10-24-15(19-13)20-14(21)18-8-9-25(3,22)23/h4-7,10H,8-9H2,1-3H3,(H2,18,19,20,21) PQLHWAVSLVVJHG-UHFFFAOYSA-N 662153 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(2- (methylsulfonyl)ethyl)urea::US20240109853, Compound A066::US20240226094, Compound A066::US20250241908, Compound A066::US20250381196, Compound A066 Alpha-protein kinase 1 Homo sapiens 126 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662153&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407828 496710614 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119967 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1)c1ccc(I)cc1 InChI=1S/C24H28IN5OS/c1-24(2,18-5-7-19(25)8-6-18)21-16-32-23(28-21)29-22(31)27-15-17-3-9-20(10-4-17)30-13-11-26-12-14-30/h3-10,16,26H,11-15H2,1-2H3,(H2,27,28,29,31) KHGJWAOJTPKDDM-UHFFFAOYSA-N 662154 1-(4-(2-(4- iodophenyl)propan-2- yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A067::US20250241908, Compound A067::US20250381196, Compound A067 Alpha-protein kinase 1 Homo sapiens 28.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662154&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407695 496710615 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119968 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCC(N)C2)n1)c1ccc(Cl)cc1 InChI=1S/C22H26ClN7OS/c1-22(2,15-3-5-16(23)6-4-15)18-13-32-21(28-18)29-20(31)27-11-14-9-25-19(26-10-14)30-8-7-17(24)12-30/h3-6,9-10,13,17H,7-8,11-12,24H2,1-2H3,(H2,27,28,29,31) XCZLUHYWOMMGMG-UHFFFAOYSA-N 662155 1-((2-(3- aminopyrrolidin-1- yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- chlorophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A068::US20240226094, Compound A068::US20250241908, Compound A068::US20250381196, Compound A068 Alpha-protein kinase 1 Homo sapiens 269 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662155&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407676 496710616 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119969 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)N2CCC(O)C2)n1 InChI=1S/C25H30N4O3S/c1-25(2,18-6-10-21(32-3)11-7-18)22-16-33-24(27-22)28-23(31)26-14-17-4-8-19(9-5-17)29-13-12-20(30)15-29/h4-11,16,20,30H,12-15H2,1-3H3,(H2,26,27,28,31) OWBYSBADHBIWRB-UHFFFAOYSA-N 662156 1-(4-(3- hydroxypyrrolidin-1- yl)benzyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A069::US20240226094, Compound A069::US20250241908, Compound A069::US20250381196, Compound A069 Alpha-protein kinase 1 Homo sapiens 269 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662156&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407368 496710617 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119970 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCC(=O)NC2CCN(C)CC2)n1 InChI=1S/C24H35N5O3S/c1-24(2,17-7-9-19(32-4)10-8-17)20-16-33-23(27-20)28-22(31)25-13-5-6-21(30)26-18-11-14-29(3)15-12-18/h7-10,16,18H,5-6,11-15H2,1-4H3,(H,26,30)(H2,25,27,28,31) DFOCKZAPRQKWIB-UHFFFAOYSA-N 662157 4-(3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)-N-(1- methylpiperidin-4- yl)butanamide::US20240109853, Compound A070::US20240226094, Compound A070::US20250241908, Compound A070::US20250381196, Compound A070 Alpha-protein kinase 1 Homo sapiens 140 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662157&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407765 496710618 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119971 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCC(=O)NC2CCNCC2)n1 InChI=1S/C23H33N5O3S/c1-23(2,16-6-8-18(31-3)9-7-16)19-15-32-22(27-19)28-21(30)25-12-4-5-20(29)26-17-10-13-24-14-11-17/h6-9,15,17,24H,4-5,10-14H2,1-3H3,(H,26,29)(H2,25,27,28,30) RRRIICHYYFYRME-UHFFFAOYSA-N 662158 4-(3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)-N-(piperidin- 4-yl)butanamide::US20240109853, Compound A071::US20240226094, Compound A071::US20250241908, Compound A071::US20250381196, Compound A071 Alpha-protein kinase 1 Homo sapiens 64.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662158 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662158&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407786 496710619 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119972 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCOCCN2CCC(N)C2)n1 InChI=1S/C22H33N5O3S/c1-22(2,16-4-6-18(29-3)7-5-16)19-15-31-21(25-19)26-20(28)24-9-12-30-13-11-27-10-8-17(23)14-27/h4-7,15,17H,8-14,23H2,1-3H3,(H2,24,25,26,28) XZQTYEMTKKQBAF-UHFFFAOYSA-N 662159 1-(2-(2-(3- aminopyrrolidin-1- yl)ethoxy)ethyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A072::US20240226094, Compound A072::US20250241908, Compound A072::US20250381196, Compound A072 Alpha-protein kinase 1 Homo sapiens 143 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662159&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407438 496710620 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119973 CC(NC(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1)c1ccc(cc1)N1CCNCC1 InChI=1S/C25H30BrN5OS/c1-17(18-4-10-21(11-5-18)31-14-12-27-13-15-31)28-23(32)30-24-29-22(16-33-24)25(2,3)19-6-8-20(26)9-7-19/h4-11,16-17,27H,12-15H2,1-3H3,(H2,28,29,30,32) RVTGHWVTLXHFLL-UHFFFAOYSA-N 662160 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(1-(4- (piperazin-1- yl)phenyl)ethyl)urea::US20240109853, Compound A073::US20240226094, Compound A073::US20250241908, Compound A073::US20250381196, Compound A073 Alpha-protein kinase 1 Homo sapiens 85.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662160 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662160&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407623 496710621 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119974 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCC(=O)CO)n1 InChI=1S/C17H21N3O4S/c1-17(2,11-4-6-13(24-3)7-5-11)14-10-25-16(19-14)20-15(23)18-8-12(22)9-21/h4-7,10,21H,8-9H2,1-3H3,(H2,18,19,20,23) YHVYGHMECUVQOG-UHFFFAOYSA-N 662161 1-(3-hydroxy-2- oxopropyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A074::US20240226094, Compound A074::US20250241908, Compound A074::US20250381196, Compound A074 Alpha-protein kinase 1 Homo sapiens 61.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662161 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662161&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407611 496710622 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119975 Cc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)N2CCNCC2)n1 InChI=1S/C25H31N5OS/c1-18-4-8-20(9-5-18)25(2,3)22-17-32-24(28-22)29-23(31)27-16-19-6-10-21(11-7-19)30-14-12-26-13-15-30/h4-11,17,26H,12-16H2,1-3H3,(H2,27,28,29,31) NXNVOZQPZBQZQY-UHFFFAOYSA-N 662162 1-(4-(piperazin-1- yl)benzyl)-3-(4-(2-(p- tolyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A075::US20240226094, Compound A075::US20250241908, Compound A075::US20250381196, Compound A075 Alpha-protein kinase 1 Homo sapiens 25.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662162 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662162&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407737 496710623 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119976 CCC(C)(c1csc(NC(=O)NC(C)c2ccc(cc2)N2CCNCC2)n1)c1ccc(OC)cc1 InChI=1S/C27H35N5O2S/c1-5-27(3,21-8-12-23(34-4)13-9-21)24-18-35-26(30-24)31-25(33)29-19(2)20-6-10-22(11-7-20)32-16-14-28-15-17-32/h6-13,18-19,28H,5,14-17H2,1-4H3,(H2,29,30,31,33) JQUDVTYQWYFFKO-UHFFFAOYSA-N 662163 1-(4-(2-(4- methoxyphenyl)butan-2- yl)thiazol-2-yl)-3-(1-(4- (piperazin-1- yl)phenyl)ethyl)urea::US20240109853, Compound A076::US20240226094, Compound A076::US20250241908, Compound A076::US20250381196, Compound A076 Alpha-protein kinase 1 Homo sapiens 147 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662163&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407450 496710624 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119977 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCCN2CCC(N)C2)n1 InChI=1S/C22H33N5O2S/c1-22(2,16-6-8-18(29-3)9-7-16)19-15-30-21(25-19)26-20(28)24-11-4-5-12-27-13-10-17(23)14-27/h6-9,15,17H,4-5,10-14,23H2,1-3H3,(H2,24,25,26,28) QSEIQAJRKINDBF-UHFFFAOYSA-N 662164 1-(4-(3- aminopyrrolidin-1- yl)butyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A077::US20240226094, Compound A077::US20250241908, Compound A077::US20250381196, Compound A077 Alpha-protein kinase 1 Homo sapiens 180 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662164&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407469 496710625 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119978 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCC(N)C2)n1)c1ccc(Br)cc1 InChI=1S/C22H26BrN7OS/c1-22(2,15-3-5-16(23)6-4-15)18-13-32-21(28-18)29-20(31)27-11-14-9-25-19(26-10-14)30-8-7-17(24)12-30/h3-6,9-10,13,17H,7-8,11-12,24H2,1-2H3,(H2,27,28,29,31) HSCKZUDKQFNMFK-UHFFFAOYSA-N 662165 1-((2-(3- aminopyrrolidin-1- yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A078::US20240226094, Compound A078::US20250241908, Compound A078::US20250381196, Compound A078 Alpha-protein kinase 1 Homo sapiens 8.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662165&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407618 496710626 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119979 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCC(O)C2)n1)c1ccc(Br)cc1 InChI=1S/C22H25BrN6O2S/c1-22(2,15-3-5-16(23)6-4-15)18-13-32-21(27-18)28-20(31)26-11-14-9-24-19(25-10-14)29-8-7-17(30)12-29/h3-6,9-10,13,17,30H,7-8,11-12H2,1-2H3,(H2,26,27,28,31) IRSVNELEONHRLE-UHFFFAOYSA-N 662166 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2-(3- hydroxypyrrolidin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A079::US20240226094, Compound A079::US20250241908, Compound A079::US20250381196, Compound A079 Alpha-protein kinase 1 Homo sapiens 170 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662166 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662166&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407605 496710627 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119980 COc1ncc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)cn1 InChI=1S/C19H20BrN5O2S/c1-19(2,13-4-6-14(20)7-5-13)15-11-28-18(24-15)25-16(26)21-8-12-9-22-17(27-3)23-10-12/h4-7,9-11H,8H2,1-3H3,(H2,21,24,25,26) NIEXEWKOIZDAPY-UHFFFAOYSA-N 662167 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2- methoxypyrimidin-5- yl)methyl)urea::US20240109853, Compound A080::US20240226094, Compound A080::US20250241908, Compound A080::US20250381196, Compound A080 Alpha-protein kinase 1 Homo sapiens 172 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662167&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407777 496710628 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119981 CC(C)(c1csc(NC(=O)NCc2cnc(NCCN)nc2)n1)c1ccc(Br)cc1 InChI=1S/C20H24BrN7OS/c1-20(2,14-3-5-15(21)6-4-14)16-12-30-19(27-16)28-18(29)26-11-13-9-24-17(25-10-13)23-8-7-22/h3-6,9-10,12H,7-8,11,22H2,1-2H3,(H,23,24,25)(H2,26,27,28,29) QLCJIVVCLCJYBD-UHFFFAOYSA-N 662168 1-((2-((2- aminoethyl)amino)pyri- midin-5-yl)methyl)-3- (4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A081::US20240226094, Compound A081::US20250241908, Compound A081::US20250381196, Compound A081 Alpha-protein kinase 1 Homo sapiens 17.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662168&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407734 496710629 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119982 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCC(O)CC2)n1)c1ccc(Br)cc1 InChI=1S/C23H27BrN6O2S/c1-23(2,16-3-5-17(24)6-4-16)19-14-33-22(28-19)29-21(32)27-13-15-11-25-20(26-12-15)30-9-7-18(31)8-10-30/h3-6,11-12,14,18,31H,7-10,13H2,1-2H3,(H2,27,28,29,32) BREWHBPCNXNKDM-UHFFFAOYSA-N 662169 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2-(4- hydroxypiperidin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A082::US20240226094, Compound A082::US20250241908, Compound A082::US20250381196, Compound A082 Alpha-protein kinase 1 Homo sapiens 125 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662169&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407408 496710630 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119983 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2)N2CCC(O)C2)n1 InChI=1S/C23H28N6O3S/c1-23(2,16-4-6-18(32-3)7-5-16)19-14-33-22(27-19)28-21(31)26-12-15-10-24-20(25-11-15)29-9-8-17(30)13-29/h4-7,10-11,14,17,30H,8-9,12-13H2,1-3H3,(H2,26,27,28,31) FZPCJKOQWDBIGI-UHFFFAOYSA-N 662170 1-((2-(3- hydroxypyrrolidin-1- yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A083::US20240226094, Compound A083::US20250241908, Compound A083::US20250381196, Compound A083 Alpha-protein kinase 1 Homo sapiens 111 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662170 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662170&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407510 496710631 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119984 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C22H26ClN7OS/c1-22(2,16-3-5-17(23)6-4-16)18-14-32-21(28-18)29-20(31)27-13-15-11-25-19(26-12-15)30-9-7-24-8-10-30/h3-6,11-12,14,24H,7-10,13H2,1-2H3,(H2,27,28,29,31) OREAKSDKSZRUCP-UHFFFAOYSA-N 662171 1-(4-(2-(4- chlorophenyl)propan-2- yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A084::US20240226094, Compound A084::US20250241908, Compound A084::US20250381196, Compound A084 Alpha-protein kinase 1 Homo sapiens 22.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662171 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662171&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407574 496710632 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119985 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1)c1ccc(F)cc1 InChI=1S/C22H26FN7OS/c1-22(2,16-3-5-17(23)6-4-16)18-14-32-21(28-18)29-20(31)27-13-15-11-25-19(26-12-15)30-9-7-24-8-10-30/h3-6,11-12,14,24H,7-10,13H2,1-2H3,(H2,27,28,29,31) CRYYDQBSHUFRBM-UHFFFAOYSA-N 662172 1-(4-(2-(4- fluorophenyl)propan-2- yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A085::US20240226094, Compound A085::US20250241908, Compound A085::US20250381196, Compound A085 Alpha-protein kinase 1 Homo sapiens 85.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662172&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407386 496710633 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119986 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1 InChI=1S/C23H29N7O2S/c1-23(2,17-4-6-18(32-3)7-5-17)19-15-33-22(28-19)29-21(31)27-14-16-12-25-20(26-13-16)30-10-8-24-9-11-30/h4-7,12-13,15,24H,8-11,14H2,1-3H3,(H2,27,28,29,31) SZHIRHSOPPHZEC-UHFFFAOYSA-N 662173 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A086::US20240226094, Compound A086::US20250241908, Compound A086::US20250381196, Compound A086 Alpha-protein kinase 1 Homo sapiens 16.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662173 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662173&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407805 496710634 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119987 CCOc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1 InChI=1S/C24H31N7O2S/c1-4-33-19-7-5-18(6-8-19)24(2,3)20-16-34-23(29-20)30-22(32)28-15-17-13-26-21(27-14-17)31-11-9-25-10-12-31/h5-8,13-14,16,25H,4,9-12,15H2,1-3H3,(H2,28,29,30,32) TYBGOYUAVBIHQZ-UHFFFAOYSA-N 662174 1-(4-(2-(4- ethoxyphenyl)propan-2- yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A087::US20240226094, Compound A087::US20250241908, Compound A087::US20250381196, Compound A087 Alpha-protein kinase 1 Homo sapiens 89.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662174&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407466 496710635 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119988 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C22H26BrN7OS/c1-22(2,16-3-5-17(23)6-4-16)18-14-32-21(28-18)29-20(31)27-13-15-11-25-19(26-12-15)30-9-7-24-8-10-30/h3-6,11-12,14,24H,7-10,13H2,1-2H3,(H2,27,28,29,31) FBNRYGBJQFIVNW-UHFFFAOYSA-N 662175 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea compound with methane (1:1)::US20240109853, Compound A088::US20240226094, Compound A088::US20250241908, Compound A088::US20250381196, Compound A088 Alpha-protein kinase 1 Homo sapiens 13.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662175 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662175&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407416 496710636 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119989 Cc1nc(ncc1CNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1)N1CCNCC1 InChI=1S/C23H28BrN7OS/c1-15-16(12-26-20(28-15)31-10-8-25-9-11-31)13-27-21(32)30-22-29-19(14-33-22)23(2,3)17-4-6-18(24)7-5-17/h4-7,12,14,25H,8-11,13H2,1-3H3,(H2,27,29,30,32) MSTQOGDEUHGSFB-UHFFFAOYSA-N 662176 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((4- methyl-2-(piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A089::US20240226094, Compound A089::US20250241908, Compound A089::US20250381196, Compound A089 Alpha-protein kinase 1 Homo sapiens 26.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662176&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407607 496710637 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119990 CC(C)(c1csc(NC(=O)NCc2ccnc(n2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C22H26BrN7OS/c1-22(2,15-3-5-16(23)6-4-15)18-14-32-21(28-18)29-20(31)26-13-17-7-8-25-19(27-17)30-11-9-24-10-12-30/h3-8,14,24H,9-13H2,1-2H3,(H2,26,28,29,31) QOSVBQMSBVHYRI-UHFFFAOYSA-N 684674 1-(4-(2-(4- bromophenyl)propan- 2-yl)thiazol-2-yl)-3- ((2-(piperazin-1- yl)pyrimidin-4- yl)methyl)urea::US20240226094, Compound A090::US20250241908, Compound A090::US20250381196, Compound A090 Alpha-protein kinase 1 Homo sapiens 178 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=684674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=684674&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407847 503274041 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119991 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C23H28BrN7OS/c1-23(2,17-4-6-18(24)7-5-17)19-15-33-22(29-19)30-21(32)28-14-16-12-26-20(27-13-16)31-10-3-8-25-9-11-31/h4-7,12-13,15,25H,3,8-11,14H2,1-2H3,(H2,28,29,30,32) LXHBKVLEQHRPHE-UHFFFAOYSA-N 662178 1-((2-(1,4-diazepan-1- yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A091::US20240226094, Compound A091::US20250241908, Compound A091::US20250381196, Compound A091 Alpha-protein kinase 1 Homo sapiens 135 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662178&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407675 496710639 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119992 CC(C)(c1csc(NC(=O)NCc2ccc(nc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C23H27BrN6OS/c1-23(2,17-4-6-18(24)7-5-17)19-15-32-22(28-19)29-21(31)27-14-16-3-8-20(26-13-16)30-11-9-25-10-12-30/h3-8,13,15,25H,9-12,14H2,1-2H3,(H2,27,28,29,31) KEDDALKEZYEJKX-UHFFFAOYSA-N 662179 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((6- (piperazin-1-yl)pyridin- 3-yl)methyl)urea::US20240109853, Compound A092::US20240226094, Compound A092::US20250241908, Compound A092::US20250381196, Compound A092 Alpha-protein kinase 1 Homo sapiens 20.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662179 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662179&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221904 496710640 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119993 CC(C)(c1csc(NC(=O)NCc2cnc(cn2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C22H26BrN7OS/c1-22(2,15-3-5-16(23)6-4-15)18-14-32-21(28-18)29-20(31)27-12-17-11-26-19(13-25-17)30-9-7-24-8-10-30/h3-6,11,13-14,24H,7-10,12H2,1-2H3,(H2,27,28,29,31) JGOUBPIMFUTONQ-UHFFFAOYSA-N 662180 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((5- (piperazin-1-yl)pyrazin- 2-yl)methyl)urea::US20240109853, Compound A093::US20240226094, Compound A093::US20250241908, Compound A093::US20250381196, Compound A093 Alpha-protein kinase 1 Homo sapiens 0.000 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662180&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407415 496710641 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119994 CC(C)(c1csc(NC(=O)NCc2cc(ncn2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C22H26BrN7OS/c1-22(2,15-3-5-16(23)6-4-15)18-13-32-21(28-18)29-20(31)25-12-17-11-19(27-14-26-17)30-9-7-24-8-10-30/h3-6,11,13-14,24H,7-10,12H2,1-2H3,(H2,25,28,29,31) REQHAIUEXNICFQ-UHFFFAOYSA-N 662181 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((6- (piperazin-1- yl)pyrimidin-4- yl)methyl)urea::US20240109853, Compound A094::US20250241908, Compound A094::US20250381196, Compound A094 Alpha-protein kinase 1 Homo sapiens 73.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662181&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407432 496710642 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119995 Cc1nc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)cc(n1)N1CCNCC1 InChI=1S/C23H28BrN7OS/c1-15-27-18(12-20(28-15)31-10-8-25-9-11-31)13-26-21(32)30-22-29-19(14-33-22)23(2,3)16-4-6-17(24)7-5-16/h4-7,12,14,25H,8-11,13H2,1-3H3,(H2,26,29,30,32) QLWNUWPAVIQIQO-UHFFFAOYSA-N 662182 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2- methyl-6-(piperazin-1- yl)pyrimidin-4- yl)methyl)urea::US20240109853, Compound A095::US20240226094, Compound A095::US20250241908, Compound A095::US20250381196, Compound A095 Alpha-protein kinase 1 Homo sapiens 32.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662182&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407687 496710643 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119996 Cc1cc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)ccc1N1CCNCC1 InChI=1S/C25H30BrN5OS/c1-17-14-18(4-9-21(17)31-12-10-27-11-13-31)15-28-23(32)30-24-29-22(16-33-24)25(2,3)19-5-7-20(26)8-6-19/h4-9,14,16,27H,10-13,15H2,1-3H3,(H2,28,29,30,32) AYFBXNJAUYFETL-UHFFFAOYSA-N 662183 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- methyl-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A096::US20240226094, Compound A096::US20250241908, Compound A096::US20250381196, Compound A096 Alpha-protein kinase 1 Homo sapiens 69.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662183&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407783 496710644 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119997 CC(C)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(Br)c2)n1)c1ccc(Br)cc1 InChI=1S/C24H27Br2N5OS/c1-24(2,17-4-6-18(25)7-5-17)21-15-33-23(29-21)30-22(32)28-14-16-3-8-20(19(26)13-16)31-11-9-27-10-12-31/h3-8,13,15,27H,9-12,14H2,1-2H3,(H2,28,29,30,32) CMEBKDAKOVLQBT-UHFFFAOYSA-N 662184 1-(3-bromo-4- (piperazin-1-yl)benzyl)- 3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A097::US20240226094, Compound A097::US20250241908, Compound A097::US20250381196, Compound A097 Alpha-protein kinase 1 Homo sapiens 87.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662184&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407491 496710645 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119998 CC(C)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(N)c2)n1)c1ccc(Br)cc1 InChI=1S/C24H29BrN6OS/c1-24(2,17-4-6-18(25)7-5-17)21-15-33-23(29-21)30-22(32)28-14-16-3-8-20(19(26)13-16)31-11-9-27-10-12-31/h3-8,13,15,27H,9-12,14,26H2,1-2H3,(H2,28,29,30,32) UVLWTTVJBCLSAQ-UHFFFAOYSA-N 662185 1-(3-amino-4- (piperazin-1-yl)benzyl)- 3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A098::US20240226094, Compound A098::US20250241908, Compound A098::US20250381196, Compound A098 Alpha-protein kinase 1 Homo sapiens 31.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662185&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407668 496710646 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 119999 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCC(N)CC2)n1)c1ccc(Br)cc1 InChI=1S/C23H28BrN7OS/c1-23(2,16-3-5-17(24)6-4-16)19-14-33-22(29-19)30-21(32)28-13-15-11-26-20(27-12-15)31-9-7-18(25)8-10-31/h3-6,11-12,14,18H,7-10,13,25H2,1-2H3,(H2,28,29,30,32) ILSSPVWEMHAJPH-UHFFFAOYSA-N 662186 1-((2-(4-aminopiperidin- 1-yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A099::US20240226094, Compound A099::US20250241908, Compound A099::US20250381196, Compound A099 Alpha-protein kinase 1 Homo sapiens 13.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662186&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407792 496710647 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120000 CN1CCC(CC1)NC(=O)C1CCC(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)CC1 |(-12.88,-5.19,;-11.55,-4.42,;-11.55,-2.88,;-10.21,-2.11,;-8.88,-2.88,;-8.88,-4.42,;-10.21,-5.19,;-7.54,-2.11,;-6.21,-2.88,;-6.21,-4.42,;-4.88,-2.11,;-3.54,-2.88,;-2.21,-2.11,;-2.21,-.57,;-.88,.2,;.46,-.57,;1.79,.2,;1.79,1.74,;3.13,-.57,;4.46,.2,;4.62,1.73,;6.13,2.05,;6.9,.72,;5.87,-.43,;6.75,3.46,;7.15,4.95,;5.27,3.86,;8.28,3.62,;9.19,2.37,;10.72,2.54,;11.35,3.94,;12.88,4.1,;10.44,5.19,;8.91,5.03,;-3.54,.2,;-4.88,-.57,)| InChI=1S/C27H38BrN5O2S/c1-27(2,20-8-10-21(28)11-9-20)23-17-36-26(31-23)32-25(35)29-16-18-4-6-19(7-5-18)24(34)30-22-12-14-33(3)15-13-22/h8-11,17-19,22H,4-7,12-16H2,1-3H3,(H,30,34)(H2,29,31,32,35) YDRKDLPZHLVBDB-UHFFFAOYSA-N 662187 4-((3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2- yl)ureido)methyl)-N-(1- methylpiperidin-4- yl)cyclohexane-1- carboxamide::US20240109853, Compound A100::US20240226094, Compound A100::US20250241908, Compound A100::US20250381196, Compound A100 Alpha-protein kinase 1 Homo sapiens 72.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662187&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407601 496710648 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120001 CC(C)(c1csc(NC(=O)NC(CO)c2ccc(cc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C25H30BrN5O2S/c1-25(2,18-5-7-19(26)8-6-18)22-16-34-24(29-22)30-23(33)28-21(15-32)17-3-9-20(10-4-17)31-13-11-27-12-14-31/h3-10,16,21,27,32H,11-15H2,1-2H3,(H2,28,29,30,33) AXMHXKGAOMRTIQ-UHFFFAOYSA-N 662188 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(2- hydroxy-1-(4- (piperazin-1- yl)phenyl)ethyl)urea::US20240109853, Compound A101::US20240226094, Compound A101::US20250241908, Compound A101::US20250381196, Compound A101 Alpha-protein kinase 1 Homo sapiens 50.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662188&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407400 496710649 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120002 CC(C)(c1csc(NC(=O)NCCCN2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C20H28BrN5OS/c1-20(2,15-4-6-16(21)7-5-15)17-14-28-19(24-17)25-18(27)23-8-3-11-26-12-9-22-10-13-26/h4-7,14,22H,3,8-13H2,1-2H3,(H2,23,24,25,27) VCLPVOSQCSAOIZ-UHFFFAOYSA-N 662189 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- (piperazin-1- yl)propyl)urea::US20240109853, Compound A102::US20240226094, Compound A102::US20250241908, Compound A102::US20250381196, Compound A102 Alpha-protein kinase 1 Homo sapiens 90.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662189&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407801 496710650 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120003 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCN(CCO)CC2)n1)c1ccc(Br)cc1 InChI=1S/C24H30BrN7O2S/c1-24(2,18-3-5-19(25)6-4-18)20-16-35-23(29-20)30-22(34)28-15-17-13-26-21(27-14-17)32-9-7-31(8-10-32)11-12-33/h3-6,13-14,16,33H,7-12,15H2,1-2H3,(H2,28,29,30,34) AIXIFUSYZPVZIN-UHFFFAOYSA-N 662190 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2-(4- (2- hydroxyethyl)piperazin- 1-yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A103::US20240226094, Compound A103::US20250241908, Compound A103::US20250381196, Compound A103 Alpha-protein kinase 1 Homo sapiens 97.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662190&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407863 496710651 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120004 COc3ccc(C(C)(C)c2csc(NC(=O)NCc1cncnc1)n2)cc3 InChI=1S/C19H21N5O2S/c1-19(2,14-4-6-15(26-3)7-5-14)16-11-27-18(23-16)24-17(25)22-10-13-8-20-12-21-9-13/h4-9,11-12H,10H2,1-3H3,(H2,22,23,24,25) BUEVYMRQCVJPJU-UHFFFAOYSA-N 662191 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3- (pyrimidin-5- ylmethyl)urea::US20240109853, Compound A104::US20250241908, Compound A104::US20250381196, Compound A104 Alpha-protein kinase 1 Homo sapiens 223 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662191&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120005 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(NCCO)c(F)c2)n1 InChI=1S/C22H26FN5O3S/c1-22(2,15-4-6-16(31-3)7-5-15)18-13-32-21(27-18)28-20(30)26-12-14-10-17(23)19(25-11-14)24-8-9-29/h4-7,10-11,13,29H,8-9,12H2,1-3H3,(H,24,25)(H2,26,27,28,30) IGPGYGVCSXAPOB-UHFFFAOYSA-N 662192 1-((5-fluoro-6-((2- hydroxyethyl)amino)pyri- din-3-yl)methyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A105::US20240226094, Compound A105::US20250241908, Compound A105::US20250381196, Compound A105 Alpha-protein kinase 1 Homo sapiens 144 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662192&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407423 496710652 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120006 CN(C)C1CCN(C1)c1ccc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)cn1 InChI=1S/C25H31BrN6OS/c1-25(2,18-6-8-19(26)9-7-18)21-16-34-24(29-21)30-23(33)28-14-17-5-10-22(27-13-17)32-12-11-20(15-32)31(3)4/h5-10,13,16,20H,11-12,14-15H2,1-4H3,(H2,28,29,30,33) LKXASIORPKANBC-UHFFFAOYSA-N 662193 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((6-(3- (dimethylamino)pyrrolidin- 1-yl)pyridin-3- yl)methyl)urea::US20240109853, Compound A106::US20240226094, Compound A106::US20250241908, Compound A106::US20250381196, Compound A106 Alpha-protein kinase 1 Homo sapiens 48.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662193&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407514 496710653 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120007 COc1ccc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)cc1F InChI=1S/C21H21BrFN3O2S/c1-21(2,14-5-7-15(22)8-6-14)18-12-29-20(25-18)26-19(27)24-11-13-4-9-17(28-3)16(23)10-13/h4-10,12H,11H2,1-3H3,(H2,24,25,26,27) FYQXINOLSIXTEG-UHFFFAOYSA-N 662194 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- fluoro-4- methoxybenzyl)urea::US20240109853, Compound A107::US20240226094, Compound A107::US20250381196, Compound A107 Alpha-protein kinase 1 Homo sapiens 216 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662194&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407442 496710654 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120008 CC(C)(c1csc(NC(=O)NCc2ccc(NCCO)cc2)n1)c1ccc(Br)cc1 InChI=1S/C22H25BrN4O2S/c1-22(2,16-5-7-17(23)8-6-16)19-14-30-21(26-19)27-20(29)25-13-15-3-9-18(10-4-15)24-11-12-28/h3-10,14,24,28H,11-13H2,1-2H3,(H2,25,26,27,29) LVEZXZLCUOPYBQ-UHFFFAOYSA-N 662195 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-((2- hydroxyethyl)amino)ben- zyl)urea::US20240109853, Compound A108::US20240226094, Compound A108::US20250241908, Compound A108::US20250381196, Compound A108 Alpha-protein kinase 1 Homo sapiens 244 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662195 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662195&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407372 496710655 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120009 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(NCCO)cc2)n1 InChI=1S/C23H28N4O3S/c1-23(2,17-6-10-19(30-3)11-7-17)20-15-31-22(26-20)27-21(29)25-14-16-4-8-18(9-5-16)24-12-13-28/h4-11,15,24,28H,12-14H2,1-3H3,(H2,25,26,27,29) OFYVQSYAHKWERN-UHFFFAOYSA-N 662196 1-(4-((2- hydroxyethyl)amino)ben- zyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A109::US20240226094, Compound A109::US20250241908, Compound A109::US20250381196, Compound A109 Alpha-protein kinase 1 Homo sapiens 146 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662196&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407520 496710656 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120010 COCCNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(OC)cc1 InChI=1S/C17H23N3O3S/c1-17(2,12-5-7-13(23-4)8-6-12)14-11-24-16(19-14)20-15(21)18-9-10-22-3/h5-8,11H,9-10H2,1-4H3,(H2,18,19,20,21) NOTFFOSACWTQND-UHFFFAOYSA-N 662197 1-(2-methoxyethyl)-3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A110::US20240226094, Compound A110::US20250241908, Compound A110::US20250381196, Compound A110 Alpha-protein kinase 1 Homo sapiens 193 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662197 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662197&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407743 496710657 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120011 COCCCNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(OC)cc1 InChI=1S/C18H25N3O3S/c1-18(2,13-6-8-14(24-4)9-7-13)15-12-25-17(20-15)21-16(22)19-10-5-11-23-3/h6-9,12H,5,10-11H2,1-4H3,(H2,19,20,21,22) FCFMAQKVALVQRM-UHFFFAOYSA-N 662198 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(3- methoxypropyl)urea::US20240109853, Compound A111::US20240226094, Compound A111::US20250241908, Compound A111::US20250381196, Compound A111 Alpha-protein kinase 1 Homo sapiens 127 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662198&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407598 496710658 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120012 CC(C)(c1csc(NC(=O)NCc2cnc(N3CCNC(=O)C3)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C23H24BrFN6O2S/c1-23(2,15-3-5-16(24)6-4-15)18-13-34-22(29-18)30-21(33)28-11-14-9-17(25)20(27-10-14)31-8-7-26-19(32)12-31/h3-6,9-10,13H,7-8,11-12H2,1-2H3,(H,26,32)(H2,28,29,30,33) CFSXIFFXAXFXSF-UHFFFAOYSA-N 662199 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((5- fluoro-6-(3- oxopiperazin-1- yl)pyridin-3- yl)methyl)urea::US20240109853, Compound A112::US20240226094, Compound A112::US20250241908, Compound A112::US20250381196, Compound A112 Alpha-protein kinase 1 Homo sapiens 334 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662199 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662199&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407723 496710659 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120013 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCNC(=O)C2)n1)c1ccc(Br)cc1 InChI=1S/C22H24BrN7O2S/c1-22(2,15-3-5-16(23)6-4-15)17-13-33-21(28-17)29-20(32)27-11-14-9-25-19(26-10-14)30-8-7-24-18(31)12-30/h3-6,9-10,13H,7-8,11-12H2,1-2H3,(H,24,31)(H2,27,28,29,32) OPWZDSNRCLSSCJ-UHFFFAOYSA-N 662200 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2-(3- oxopiperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A113::US20240226094, Compound A113::US20250241908, Compound A113::US20250381196, Compound A113 Alpha-protein kinase 1 Homo sapiens 126 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662200 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662200&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407493 496710660 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120014 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCC(N)=O)n1 InChI=1S/C18H24N4O3S/c1-18(2,12-6-8-13(25-3)9-7-12)14-11-26-17(21-14)22-16(24)20-10-4-5-15(19)23/h6-9,11H,4-5,10H2,1-3H3,(H2,19,23)(H2,20,21,22,24) CVJNGVJWGSPVSM-UHFFFAOYSA-N 662201 4-(3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)butanamide::US20240109853, Compound A114::US20240226094, Compound A114::US20250241908, Compound A114::US20250381196, Compound A114 Alpha-protein kinase 1 Homo sapiens 260 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662201&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407818 496710661 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120015 CCCN1CCC(CC1)NC(=O)c1ccc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(OC)cc2)cn1 InChI=1S/C29H38N6O3S/c1-5-14-35-15-12-22(13-16-35)32-26(36)24-11-6-20(17-30-24)18-31-27(37)34-28-33-25(19-39-28)29(2,3)21-7-9-23(38-4)10-8-21/h6-11,17,19,22H,5,12-16,18H2,1-4H3,(H,32,36)(H2,31,33,34,37) ZEMOPPAGSWXSDA-UHFFFAOYSA-N 662202 5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N-(1- propylpiperidin-4- yl)picolinamide::US20240109853, Compound A115::US20240226094, Compound A115::US20250241908, Compound A115::US20250381196, Compound A115 Alpha-protein kinase 1 Homo sapiens 19.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662202 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662202&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407700 496710662 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120016 CCCN1CCN(CC1)c1ccc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(OC)cc2)cc1C(N)=O InChI=1S/C29H38N6O3S/c1-5-12-34-13-15-35(16-14-34)24-11-6-20(17-23(24)26(30)36)18-31-27(37)33-28-32-25(19-39-28)29(2,3)21-7-9-22(38-4)10-8-21/h6-11,17,19H,5,12-16,18H2,1-4H3,(H2,30,36)(H2,31,32,33,37) RQHUGJHORZSSLQ-UHFFFAOYSA-N 662203 5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-2-(4- propylpiperazin-1- yl)benzamide::US20240109853, Compound A116::US20240226094, Compound A116::US20250241908, Compound A116::US20250381196, Compound A116 Alpha-protein kinase 1 Homo sapiens 72.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662203&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407612 496710663 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120017 CN1CCN(Cc2c(F)cc(CNC(=O)Nc3nc(cs3)C(C)(C)c3ccc(Br)cc3)cc2F)CC1 InChI=1S/C26H30BrF2N5OS/c1-26(2,18-4-6-19(27)7-5-18)23-16-36-25(31-23)32-24(35)30-14-17-12-21(28)20(22(29)13-17)15-34-10-8-33(3)9-11-34/h4-7,12-13,16H,8-11,14-15H2,1-3H3,(H2,30,31,32,35) MVGCHFSNTBYNJT-UHFFFAOYSA-N 662204 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3,5- difluoro-4-((4- methylpiperazin-1- yl)methyl)benzyl)urea::US20240109853, Compound A117::US20240226094, Compound A117::US20250241908, Compound A117::US20250381196, Compound A117 Alpha-protein kinase 1 Homo sapiens 67.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662204&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407677 496710664 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120018 CC(NC(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1)c1ccc(CN2CCN(C)CC2)cc1 InChI=1S/C27H34BrN5OS/c1-19(21-7-5-20(6-8-21)17-33-15-13-32(4)14-16-33)29-25(34)31-26-30-24(18-35-26)27(2,3)22-9-11-23(28)12-10-22/h5-12,18-19H,13-17H2,1-4H3,(H2,29,30,31,34) PLUGQKYFDYWJCX-UHFFFAOYSA-N 662205 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(1-(4- ((4-methylpiperazin-1- yl)methyl)phenyl)ethyl) urea::US20240109853, Compound A118::US20250241908, Compound A118::US20250381196, Compound A118 Alpha-protein kinase 1 Homo sapiens 227 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662205 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662205&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407536 496710665 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120019 CC(C)(c1csc(NC(=O)NCc2cnc(NCCO)nc2)n1)c1ccc(Br)cc1 InChI=1S/C20H23BrN6O2S/c1-20(2,14-3-5-15(21)6-4-14)16-12-30-19(26-16)27-18(29)25-11-13-9-23-17(24-10-13)22-7-8-28/h3-6,9-10,12,28H,7-8,11H2,1-2H3,(H,22,23,24)(H2,25,26,27,29) BDWRFRVZZVWKNI-UHFFFAOYSA-N 662206 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2- ((2- hydroxyethyl)amino)pyri- midin-5-yl)methyl)urea::US20240109853, Compound A119::US20240226094, Compound A119::US20250241908, Compound A119::US20250381196, Compound A119 Alpha-protein kinase 1 Homo sapiens 36.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662206 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662206&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407568 496710666 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120020 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(nc2)C(=O)NC2CCN(C)CC2)n1 InChI=1S/C27H34N6O3S/c1-27(2,19-6-8-21(36-4)9-7-19)23-17-37-26(31-23)32-25(35)29-16-18-5-10-22(28-15-18)24(34)30-20-11-13-33(3)14-12-20/h5-10,15,17,20H,11-14,16H2,1-4H3,(H,30,34)(H2,29,31,32,35) AGXSEIODEVDACW-UHFFFAOYSA-N 662102 US20240109853, Compound A120::5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N-(1- methylpiperidin-4- yl)picolinamide::US20240109853, Compound A015::US20240226094, Compound A120::US20250241908, Compound A120::US20250381196, Compound A120 Alpha-protein kinase 1 Homo sapiens 53.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662102 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662102&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407600 496710564 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120021 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(N3CCNC(=O)C3)c(F)c2)n1 InChI=1S/C24H27FN6O3S/c1-24(2,16-4-6-17(34-3)7-5-16)19-14-35-23(29-19)30-22(33)28-12-15-10-18(25)21(27-11-15)31-9-8-26-20(32)13-31/h4-7,10-11,14H,8-9,12-13H2,1-3H3,(H,26,32)(H2,28,29,30,33) IMYUDOURMJGZDM-UHFFFAOYSA-N 662208 1-((5-fluoro-6-(3- oxopiperaizn-1- yl)pyridin-3-yl)methyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A121::US20240226094, Compound A121::US20250241908, Compound A121::US20250381196, Compound A121 Alpha-protein kinase 1 Homo sapiens 209 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662208&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407876 496710667 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120022 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NC2CCC(O)CC2)n1 |(9.25,3.05,;8.62,1.64,;7.09,1.48,;6.41,.06,;4.88,-.1,;3.97,1.15,;4.6,2.56,;6.13,2.72,;2.44,.99,;1.1,1.76,;2.44,2.53,;1.81,-.42,;2.58,-1.75,;1.55,-2.9,;.14,-2.27,;-1.19,-3.04,;-2.52,-2.27,;-2.52,-.73,;-3.86,-3.04,;-5.19,-2.27,;-5.19,-.73,;-6.52,.04,;-7.86,-.73,;-9.19,.04,;-7.86,-2.27,;-6.52,-3.04,;.31,-.74,)| InChI=1S/C20H27N3O3S/c1-20(2,13-4-10-16(26-3)11-5-13)17-12-27-19(22-17)23-18(25)21-14-6-8-15(24)9-7-14/h4-5,10-12,14-15,24H,6-9H2,1-3H3,(H2,21,22,23,25) UANGELLMYGCNIQ-UHFFFAOYSA-N 662209 1-(4- hydroxycyclohexyl)-3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A122::US20240226094, Compound A122::US20250241908, Compound A122::US20250381196, Compound A122 Alpha-protein kinase 1 Homo sapiens 219 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662209 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662209&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407465 496710668 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120023 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NC2CCCC(O)C2)n1 InChI=1S/C20H27N3O3S/c1-20(2,13-7-9-16(26-3)10-8-13)17-12-27-19(22-17)23-18(25)21-14-5-4-6-15(24)11-14/h7-10,12,14-15,24H,4-6,11H2,1-3H3,(H2,21,22,23,25) ZSLYPNSEPAYUBM-UHFFFAOYSA-N 662210 1-(3- hydroxycyclohexyl)-3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A123::US20240226094, Compound A123::US20250241908, Compound A123::US20250381196, Compound A123 Alpha-protein kinase 1 Homo sapiens 354 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662210 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662210&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407820 496710669 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120024 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCc2ccncc2)n1 InChI=1S/C21H24N4O2S/c1-21(2,16-4-6-17(27-3)7-5-16)18-14-28-20(24-18)25-19(26)23-13-10-15-8-11-22-12-9-15/h4-9,11-12,14H,10,13H2,1-3H3,(H2,23,24,25,26) XODBUBYGCGDKFZ-UHFFFAOYSA-N 662211 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(2- (pyridin-4-yl)ethyl)urea::US20240109853, Compound A124::US20240226094, Compound A124::US20250241908, Compound A124::US20250381196, Compound A124 Alpha-protein kinase 1 Homo sapiens 165 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662211&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407815 496710670 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120025 CC(C)NC(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1 InChI=1S/C16H20BrN3OS/c1-10(2)18-14(21)20-15-19-13(9-22-15)16(3,4)11-5-7-12(17)8-6-11/h5-10H,1-4H3,(H2,18,19,20,21) KTQKSQWCYWUVOQ-UHFFFAOYSA-N 662212 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3- isopropylurea::US20240109853, Compound A125::US20240226094, Compound A125::US20250241908, Compound A125::US20250381196, Compound A125 Alpha-protein kinase 1 Homo sapiens 28.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662212 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662212&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407535 496710671 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120026 CC(C)(c1csc(NC(=O)NCCCO)n1)c1ccc(Br)cc1 InChI=1S/C16H20BrN3O2S/c1-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-3-9-21/h4-7,10,21H,3,8-9H2,1-2H3,(H2,18,19,20,22) CQYYFZWDDLVTEV-UHFFFAOYSA-N 662213 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- hydroxypropyl)urea::US20240109853, Compound A126::US20240226094, Compound A126::US20250241908, Compound A126::US20250381196, Compound A126 Alpha-protein kinase 1 Homo sapiens 88.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662213&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407516 496710672 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120027 CC(C)(c1csc(NC(=O)NCCCN2CCOCC2)n1)c1ccc(Br)cc1 InChI=1S/C20H27BrN4O2S/c1-20(2,15-4-6-16(21)7-5-15)17-14-28-19(23-17)24-18(26)22-8-3-9-25-10-12-27-13-11-25/h4-7,14H,3,8-13H2,1-2H3,(H2,22,23,24,26) HOGHZYUTVMAISU-UHFFFAOYSA-N 662214 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- morpholinopropyl)urea::US20240109853, Compound A127::US20240226094, Compound A127::US20250241908, Compound A127::US20250381196, Compound A127 Alpha-protein kinase 1 Homo sapiens 113 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662214&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407528 496710673 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120028 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCCO)n1 InChI=1S/C18H25N3O3S/c1-18(2,13-6-8-14(24-3)9-7-13)15-12-25-17(20-15)21-16(23)19-10-4-5-11-22/h6-9,12,22H,4-5,10-11H2,1-3H3,(H2,19,20,21,23) QZUOLRPXBOKTAD-UHFFFAOYSA-N 662215 1-(4-hydroxybutyl)-3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A128::US20240226094, Compound A128::US20250241908, Compound A128::US20250381196, Compound A128 Alpha-protein kinase 1 Homo sapiens 146 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662215&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407499 496710674 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120029 CC(C)(c1csc(NC(=O)NCCCN2CCC(O)C2)n1)c1ccc(Br)cc1 InChI=1S/C20H27BrN4O2S/c1-20(2,14-4-6-15(21)7-5-14)17-13-28-19(23-17)24-18(27)22-9-3-10-25-11-8-16(26)12-25/h4-7,13,16,26H,3,8-12H2,1-2H3,(H2,22,23,24,27) CCCUMMPZLFQTQN-UHFFFAOYSA-N 662216 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3-(3- hydroxypyrrolidin-1- yl)propyl)urea::US20240109853, Compound A129::US20240226094, Compound A129::US20250241908, Compound A129::US20250381196, Compound A129 Alpha-protein kinase 1 Homo sapiens 40.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662216&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407383 496710675 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120030 CC(C)(c1csc(NC(=O)NCCCS(C)(=O)=O)n1)c1ccc(Br)cc1 InChI=1S/C17H22BrN3O3S2/c1-17(2,12-5-7-13(18)8-6-12)14-11-25-16(20-14)21-15(22)19-9-4-10-26(3,23)24/h5-8,11H,4,9-10H2,1-3H3,(H2,19,20,21,22) BVPLKADPQGYIRU-UHFFFAOYSA-N 662217 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- (methylsulfonyl)propyl) urea::US20240109853, Compound A130::US20240226094, Compound A130::US20250241908, Compound A130::US20250381196, Compound A130 Alpha-protein kinase 1 Homo sapiens 293 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662217&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407388 496710676 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120031 CC(C)(c1csc(NC(=O)NCCS(N)(=O)=O)n1)c1ccc(Br)cc1 InChI=1S/C15H19BrN4O3S2/c1-15(2,10-3-5-11(16)6-4-10)12-9-24-14(19-12)20-13(21)18-7-8-25(17,22)23/h3-6,9H,7-8H2,1-2H3,(H2,17,22,23)(H2,18,19,20,21) XBCHTMDIELDCLQ-UHFFFAOYSA-N 662218 2-(3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2- yl)ureido)ethanesulfona- mide::US20240109853, Compound A131::US20240226094, Compound A131::US20250241908, Compound A131::US20250381196, Compound A131 Alpha-protein kinase 1 Homo sapiens 219 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662218&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407707 496710677 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120032 CC(C)(c1csc(NC(=O)NCCCS(N)(=O)=O)n1)c1ccc(Br)cc1 InChI=1S/C16H21BrN4O3S2/c1-16(2,11-4-6-12(17)7-5-11)13-10-25-15(20-13)21-14(22)19-8-3-9-26(18,23)24/h4-7,10H,3,8-9H2,1-2H3,(H2,18,23,24)(H2,19,20,21,22) ZWJKJEQXPKTAND-UHFFFAOYSA-N 662219 3-(3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2- yl)ureido)propane-1- sulfonamide::US20240109853, Compound A132::US20240226094, Compound A132::US20250241908, Compound A132::US20250381196, Compound A132 Alpha-protein kinase 1 Homo sapiens 80.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662219&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407431 496710678 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120033 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCO)n1 InChI=1S/C17H23N3O3S/c1-17(2,12-5-7-13(23-3)8-6-12)14-11-24-16(19-14)20-15(22)18-9-4-10-21/h5-8,11,21H,4,9-10H2,1-3H3,(H2,18,19,20,22) UTQQAXOAJZUEAG-UHFFFAOYSA-N 662220 1-(3-hydroxypropyl)-3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A133::US20240226094, Compound A133::US20250241908, Compound A133::US20250381196, Compound A133 Alpha-protein kinase 1 Homo sapiens 57.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662220&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407784 496710679 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120034 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCN2CCOCC2)n1 InChI=1S/C21H30N4O3S/c1-21(2,16-5-7-17(27-3)8-6-16)18-15-29-20(23-18)24-19(26)22-9-4-10-25-11-13-28-14-12-25/h5-8,15H,4,9-14H2,1-3H3,(H2,22,23,24,26) VRDPTHAVVSQZAB-UHFFFAOYSA-N 662221 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(3- morpholinopropyl)urea::US20240109853, Compound A134::US20240226094, Compound A134::US20250241908, Compound A134::US20250381196, Compound A134 Alpha-protein kinase 1 Homo sapiens 152 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662221 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662221&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407812 496710680 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120035 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCN2CCC(O)C2)n1 InChI=1S/C21H30N4O3S/c1-21(2,15-5-7-17(28-3)8-6-15)18-14-29-20(23-18)24-19(27)22-10-4-11-25-12-9-16(26)13-25/h5-8,14,16,26H,4,9-13H2,1-3H3,(H2,22,23,24,27) YFYBRSHTZFDLCJ-UHFFFAOYSA-N 662222 1-(3-(3- hydroxypyrrolidin-1- yl)propyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A135::US20240226094, Compound A135::US20250241908, Compound A135::US20250381196, Compound A135 Alpha-protein kinase 1 Homo sapiens 112 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662222&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407867 496710681 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120036 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCS(C)(=O)=O)n1 InChI=1S/C18H25N3O4S2/c1-18(2,13-6-8-14(25-3)9-7-13)15-12-26-17(20-15)21-16(22)19-10-5-11-27(4,23)24/h6-9,12H,5,10-11H2,1-4H3,(H2,19,20,21,22) JDYKMMHGOVNJBW-UHFFFAOYSA-N 662223 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(3- (methylsulfonyl)propyl) urea::US20240109853, Compound A136::US20240226094, Compound A136::US20250241908, Compound A136::US20250381196, Compound A136 Alpha-protein kinase 1 Homo sapiens 209 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662223&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407791 496710682 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120037 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCS(N)(=O)=O)n1 InChI=1S/C16H22N4O4S2/c1-16(2,11-4-6-12(24-3)7-5-11)13-10-25-15(19-13)20-14(21)18-8-9-26(17,22)23/h4-7,10H,8-9H2,1-3H3,(H2,17,22,23)(H2,18,19,20,21) WYEGXEWNUWATIA-UHFFFAOYSA-N 662224 2-(3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)ethanesulfona- mide::US20240109853, Compound A137::US20240226094, Compound A137::US20250241908, Compound A137::US20250381196, Compound A137 Alpha-protein kinase 1 Homo sapiens 42.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662224&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407708 496710683 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120038 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCS(N)(=O)=O)n1 InChI=1S/C17H24N4O4S2/c1-17(2,12-5-7-13(25-3)8-6-12)14-11-26-16(20-14)21-15(22)19-9-4-10-27(18,23)24/h5-8,11H,4,9-10H2,1-3H3,(H2,18,23,24)(H2,19,20,21,22) DBPKBIHMZMNIKK-UHFFFAOYSA-N 662225 3-(3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)propane-1- sulfonamide::US20240109853, Compound A138::US20240226094, Compound A138::US20250241908, Compound A138::US20250381196, Compound A138 Alpha-protein kinase 1 Homo sapiens 97.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662225&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407579 496710684 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120039 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)N2CCC(O)CC2)n1 InChI=1S/C26H32N4O3S/c1-26(2,19-6-10-22(33-3)11-7-19)23-17-34-25(28-23)29-24(32)27-16-18-4-8-20(9-5-18)30-14-12-21(31)13-15-30/h4-11,17,21,31H,12-16H2,1-3H3,(H2,27,28,29,32) AKVJIJTTZXBZOH-UHFFFAOYSA-N 662226 1-(4-(4- hydroxypiperidin-1- yl)benzyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A139::US20240226094, Compound A139::US20250241908, Compound A139::US20250381196, Compound A139 Alpha-protein kinase 1 Homo sapiens 261 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662226&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407770 496710685 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120040 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(CO)cc2)n1 InChI=1S/C22H25N3O3S/c1-22(2,17-8-10-18(28-3)11-9-17)19-14-29-21(24-19)25-20(27)23-12-15-4-6-16(13-26)7-5-15/h4-11,14,26H,12-13H2,1-3H3,(H2,23,24,25,27) GTUXEHIKBZJMEE-UHFFFAOYSA-N 662227 1-(4- (hydroxymethyl)benzyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A140::US20240226094, Compound A140::US20250241908, Compound A140::US20250381196, Compound A140 Alpha-protein kinase 1 Homo sapiens 131 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662227 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662227&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407854 496710686 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120041 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCN2CCC(C2)N(C)C)n1 InChI=1S/C23H35N5O2S/c1-23(2,17-7-9-19(30-5)10-8-17)20-16-31-22(25-20)26-21(29)24-12-6-13-28-14-11-18(15-28)27(3)4/h7-10,16,18H,6,11-15H2,1-5H3,(H2,24,25,26,29) RJLFTJUWQSDCCQ-UHFFFAOYSA-N 662228 1-(3-(3- (dimethylamino)pyrrolidin- 1-yl)propyl)-3-(4-(2- (4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A141::US20240226094, Compound A141::US20250241908, Compound A141::US20250381196, Compound A141 Alpha-protein kinase 1 Homo sapiens 228 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662228 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662228&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407577 496710687 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120042 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCN2CCN(C)CC2)n1 InChI=1S/C22H33N5O2S/c1-22(2,17-6-8-18(29-4)9-7-17)19-16-30-21(24-19)25-20(28)23-10-5-11-27-14-12-26(3)13-15-27/h6-9,16H,5,10-15H2,1-4H3,(H2,23,24,25,28) XNKFLXHQVDYBPQ-UHFFFAOYSA-N 662229 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(3- (4-methylpiperazin-1- yl)propyl)urea::US20240109853, Compound A142::US20240226094, Compound A142::US20250241908, Compound A142::US20250381196, Compound A142 Alpha-protein kinase 1 Homo sapiens 180 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662229&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407644 496710688 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120043 CNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(OC)cc1 InChI=1S/C15H19N3O2S/c1-15(2,10-5-7-11(20-4)8-6-10)12-9-21-14(17-12)18-13(19)16-3/h5-9H,1-4H3,(H2,16,17,18,19) CINJBGIUFPFHMC-UHFFFAOYSA-N 662230 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3- methylurea::US20240109853, Compound A143::US20240226094, Compound A143::US20250241908, Compound A143::US20250381196, Compound A143 Alpha-protein kinase 1 Homo sapiens 53.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662230 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662230&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407704 496710689 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120044 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NO)n1 InChI=1S/C14H17N3O3S/c1-14(2,9-4-6-10(20-3)7-5-9)11-8-21-13(15-11)16-12(18)17-19/h4-8,19H,1-3H3,(H2,15,16,17,18) DZUXIFCUANZBPQ-UHFFFAOYSA-N 662231 1-hydroxy-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A144::US20250241908, Compound A144::US20250381196, Compound A144 Alpha-protein kinase 1 Homo sapiens 154 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662231 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662231&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407458 496710690 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120045 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCN(C)C)n1 InChI=1S/C19H28N4O2S/c1-19(2,14-7-9-15(25-5)10-8-14)16-13-26-18(21-16)22-17(24)20-11-6-12-23(3)4/h7-10,13H,6,11-12H2,1-5H3,(H2,20,21,22,24) QEKIFMIFDVOTON-UHFFFAOYSA-N 662232 1-(3- (dimethylamino)propyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A145::US20240226094, Compound A145::US20250241908, Compound A145::US20250381196, Compound A145 Alpha-protein kinase 1 Homo sapiens 216 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662232&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407868 496710691 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120046 CCN(CC)CCCNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(OC)cc1 InChI=1S/C21H32N4O2S/c1-6-25(7-2)14-8-13-22-19(26)24-20-23-18(15-28-20)21(3,4)16-9-11-17(27-5)12-10-16/h9-12,15H,6-8,13-14H2,1-5H3,(H2,22,23,24,26) KGORJLVUXJIZSF-UHFFFAOYSA-N 662233 1-(3- (diethylamino)propyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A146::US20240226094, Compound A146::US20250241908, Compound A146::US20250381196, Compound A146 Alpha-protein kinase 1 Homo sapiens 124 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662233 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662233&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407560 496710692 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120047 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCCNc2ccccc2)n1 InChI=1S/C24H30N4O2S/c1-24(2,18-11-13-20(30-3)14-12-18)21-17-31-23(27-21)28-22(29)26-16-8-7-15-25-19-9-5-4-6-10-19/h4-6,9-14,17,25H,7-8,15-16H2,1-3H3,(H2,26,27,28,29) XGKNWNHOSXWKAF-UHFFFAOYSA-N 662234 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(4- (phenylamino)butyl)urea::US20240109853, Compound A147::US20240226094, Compound A147::US20250241908, Compound A147::US20250381196, Compound A147 Alpha-protein kinase 1 Homo sapiens 235 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662234 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662234&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407874 496710693 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120048 CNS(=O)(=O)CCCNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(OC)cc1 InChI=1S/C18H26N4O4S2/c1-18(2,13-6-8-14(26-4)9-7-13)15-12-27-17(21-15)22-16(23)20-10-5-11-28(24,25)19-3/h6-9,12,19H,5,10-11H2,1-4H3,(H2,20,21,22,23) PKHPWUSMEIFCNA-UHFFFAOYSA-N 662235 3-(3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)-N- methylpropane-1- sulfonamide::US20240109853, Compound A148::US20240226094, Compound A148::US20250241908, Compound A148::US20250381196, Compound A148 Alpha-protein kinase 1 Homo sapiens 45.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662235&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407545 496710694 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120049 CNS(=O)(=O)[C@@H]1C[C@H](CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(OC)cc2)C1 |r,wD:5.4,7.7,(-10.65,.39,;-9.17,.79,;-8.77,2.28,;-10.25,1.88,;-8.37,3.77,;-7.68,1.19,;-6.14,1.19,;-6.14,-.35,;-5.05,-1.44,;-3.56,-.86,;-2.07,-1.26,;-2.07,-2.8,;-.99,-.17,;.5,-.57,;1.7,.4,;2.99,-.44,;2.59,-1.93,;1.05,-2.01,;4.43,.11,;4.67,1.63,;5.87,.66,;5.63,-.86,;5.38,-2.38,;6.58,-3.35,;8.02,-2.8,;9.22,-3.77,;10.65,-3.21,;8.26,-1.28,;7.06,-.31,;-7.68,-.35,)| InChI=1S/C20H28N4O4S2/c1-20(2,14-5-7-15(28-4)8-6-14)17-12-29-19(23-17)24-18(25)22-11-13-9-16(10-13)30(26,27)21-3/h5-8,12-13,16,21H,9-11H2,1-4H3,(H2,22,23,24,25) HKOXPHIJPBOBIL-UHFFFAOYSA-N 662236 rac-(1s,3s)-3-((3-(4-(2- (4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N- methylcyclobutane-1- sulfonamide::US20240109853, Compound A149::US20240226094, Compound A149::US20250241908, Compound A149::US20250381196, Compound A149 Alpha-protein kinase 1 Homo sapiens 155 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662236 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662236&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171665625 496710695 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120050 CNS(=O)(=O)[C@H]1C[C@H](CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(OC)cc2)C1 |r,wU:5.4,wD:7.7,(-10.65,.39,;-9.17,.79,;-8.77,2.28,;-10.25,1.88,;-8.37,3.77,;-7.68,1.19,;-6.14,1.19,;-6.14,-.35,;-5.05,-1.44,;-3.56,-.86,;-2.07,-1.26,;-2.07,-2.8,;-.99,-.17,;.5,-.57,;1.7,.4,;2.99,-.44,;2.59,-1.93,;1.05,-2.01,;4.43,.11,;4.67,1.63,;5.87,.66,;5.63,-.86,;5.38,-2.38,;6.58,-3.35,;8.02,-2.8,;9.22,-3.77,;10.65,-3.21,;8.26,-1.28,;7.06,-.31,;-7.68,-.35,)| InChI=1S/C20H28N4O4S2/c1-20(2,14-5-7-15(28-4)8-6-14)17-12-29-19(23-17)24-18(25)22-11-13-9-16(10-13)30(26,27)21-3/h5-8,12-13,16,21H,9-11H2,1-4H3,(H2,22,23,24,25) HKOXPHIJPBOBIL-UHFFFAOYSA-N 662237 rac-(1r,3r)-3-((3-(4-(2- (4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N- methylcyclobutane-1- sulfonamide::US20240109853, Compound A150::US20240226094, Compound A150::US20250241908, Compound A150::US20250381196, Compound A150 Alpha-protein kinase 1 Homo sapiens 25.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662237 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662237&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171665625 496710696 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120051 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cc(F)c(C3CCNCC3)c(F)c2)n1 InChI=1S/C26H30F2N4O2S/c1-26(2,18-4-6-19(34-3)7-5-18)22-15-35-25(31-22)32-24(33)30-14-16-12-20(27)23(21(28)13-16)17-8-10-29-11-9-17/h4-7,12-13,15,17,29H,8-11,14H2,1-3H3,(H2,30,31,32,33) CJLRJEAQOMVPAD-UHFFFAOYSA-N 662238 1-(3,5-difluoro-4- (piperidin-4-yl)benzyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea hydrochloride::US20240109853, Compound A151::US20240226094, Compound A151::US20250241908, Compound A151::US20250381196, Compound A151 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662238 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662238&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407399 496710697 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120052 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NC(C)c2cc(F)c(N3CCNCC3)c(F)c2)n1 InChI=1S/C26H31F2N5O2S/c1-16(17-13-20(27)23(21(28)14-17)33-11-9-29-10-12-33)30-24(34)32-25-31-22(15-36-25)26(2,3)18-5-7-19(35-4)8-6-18/h5-8,13-16,29H,9-12H2,1-4H3,(H2,30,31,32,34) HHGMENXMRRPEGY-UHFFFAOYSA-N 662239 1-(1-(3,5-difluoro-4- (piperazin-1- yl)phenyl)ethyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A152::US20240226094, Compound A152::US20250241908, Compound A152::US20250381196, Compound A152 Alpha-protein kinase 1 Homo sapiens 55.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662239&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407534 496710698 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120053 CC(C#C)(c1csc(NC(=O)N2CC(O)C2)n1)c1ccc(Br)cc1 InChI=1S/C17H16BrN3O2S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-24-15(19-14)20-16(23)21-8-13(22)9-21/h1,4-7,10,13,22H,8-9H2,2H3,(H,19,20,23) PSFSJWRVARBXBN-UHFFFAOYSA-N 662240 N-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- hydroxyazetidine-1- carboxamide::US20240109853, Compound A153::US20240226094, Compound A153::US20250241908, Compound A153::US20250381196, Compound A153 Alpha-protein kinase 1 Homo sapiens 76.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662240&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407810 496710699 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120054 CC(C#C)(c1csc(NC(=O)NCCCO)n1)c1ccc(Br)cc1 InChI=1S/C17H18BrN3O2S/c1-3-17(2,12-5-7-13(18)8-6-12)14-11-24-16(20-14)21-15(23)19-9-4-10-22/h1,5-8,11,22H,4,9-10H2,2H3,(H2,19,20,21,23) OCVXPRSDRLUIDC-UHFFFAOYSA-N 662241 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(3- hydroxypropyl)urea::US20240109853, Compound A154::US20240226094, Compound A154::US20250241908, Compound A154::US20250381196, Compound A154 Alpha-protein kinase 1 Homo sapiens 21.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662241&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407441 496710700 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120055 CC(C#C)(c1csc(NC(=O)NCCN2CCOCC2)n1)c1ccc(Br)cc1 InChI=1S/C20H23BrN4O2S/c1-3-20(2,15-4-6-16(21)7-5-15)17-14-28-19(23-17)24-18(26)22-8-9-25-10-12-27-13-11-25/h1,4-7,14H,8-13H2,2H3,(H2,22,23,24,26) IJDQHEAZVLYXSB-UHFFFAOYSA-N 662242 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- morpholinoethyl)urea::US20240109853, Compound A155::US20240226094, Compound A155::US20250241908, Compound A155::US20250381196, Compound A155 Alpha-protein kinase 1 Homo sapiens 30.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662242&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407719 496710701 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120056 CC(C#C)(c1csc(NC(=O)NCC(O)CO)n1)c1ccc(Br)cc1 InChI=1S/C17H18BrN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-8-13(23)9-22/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) NMJJFJMQVZYOLO-UHFFFAOYSA-N 662243 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (2,3- dihydroxypropyl)urea::US20240109853, Compound A156::US20240226094, Compound A156::US20250241908, Compound A156::US20250381196, Compound A156 Alpha-protein kinase 1 Homo sapiens 22.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662243&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407806 496710702 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120057 CCC(C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(Br)cc1 InChI=1S/C17H18BrN3O2S/c1-3-17(4-2,12-5-7-13(18)8-6-12)14-11-24-16(20-14)21-15(23)19-9-10-22/h1,5-8,11,22H,4,9-10H2,2H3,(H2,19,20,21,23) FJXWXMCIEJJPCW-UHFFFAOYSA-N 662244 1-(4-(3-(4- bromophenyl)pent-1-yn- 3-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A157::US20240226094, Compound A157::US20250241908, Compound A157::US20250381196, Compound A157 Alpha-protein kinase 1 Homo sapiens 22.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662244&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407602 496710703 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120058 OCCNC(=O)Nc1nc(cs1)C1(CCC1)c1ccc(Br)cc1 InChI=1S/C16H18BrN3O2S/c17-12-4-2-11(3-5-12)16(6-1-7-16)13-10-23-15(19-13)20-14(22)18-8-9-21/h2-5,10,21H,1,6-9H2,(H2,18,19,20,22) MTVGSSBTFNAJPX-UHFFFAOYSA-N 662245 1-(4-(1-(4- bromophenyl)cyclobutyl) thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A158::US20240226094, Compound A158::US20250241908, Compound A158::US20250381196, Compound A158 Alpha-protein kinase 1 Homo sapiens 67.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662245&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407583 496710704 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120059 CC(C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(Br)cc1 InChI=1S/C16H16BrN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22) VKXUGYUEQJOCJY-UHFFFAOYSA-N 662246 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(4- hydroxyethyl)urea::US20240109853, Compound A159::US20240226094, Compound A159::US20250241908, Compound A159::US20250381196, Compound A159 Alpha-protein kinase 1 Homo sapiens 48.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662246&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407502 496710705 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120060 C[C@@](C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(Br)cc1 |r| InChI=1S/C16H16BrN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22) VKXUGYUEQJOCJY-UHFFFAOYSA-N 662247 (S)-1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A160::US20240226094, Compound A160::US20250381196, Compound A160 Alpha-protein kinase 1 Homo sapiens 10.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662247&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407475 496710706 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120061 C[C@](C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(Br)cc1 |r| InChI=1S/C16H16BrN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22) VKXUGYUEQJOCJY-UHFFFAOYSA-N 662248 (R)-1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A161::US20240226094, Compound A161::US20250241908, Compound A161::US20250381196, Compound A161 Alpha-protein kinase 1 Homo sapiens 68.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662248 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662248&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407537 496710707 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120062 CC(C#C)(c1csc(NC(N)=O)n1)c1ccc(Br)cc1 InChI=1S/C14H12BrN3OS/c1-3-14(2,9-4-6-10(15)7-5-9)11-8-20-13(17-11)18-12(16)19/h1,4-8H,2H3,(H3,16,17,18,19) DOSZECKMPIEVMN-UHFFFAOYSA-N 662249 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A162::US20240226094, Compound A162::US20250241908, Compound A162::US20250381196, Compound A162 Alpha-protein kinase 1 Homo sapiens 38.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662249&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407714 496710708 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120063 C[C@](C#C)(c1csc(NC(N)=O)n1)c1ccc(Br)cc1 |r| InChI=1S/C14H12BrN3OS/c1-3-14(2,9-4-6-10(15)7-5-9)11-8-20-13(17-11)18-12(16)19/h1,4-8H,2H3,(H3,16,17,18,19) DOSZECKMPIEVMN-UHFFFAOYSA-N 662250 (S)-1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A163::US20240226094, Compound A163::US20250241908, Compound A163::US20250381196, Compound A163 Alpha-protein kinase 1 Homo sapiens 4.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662250 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662250&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407632 496710709 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120064 C[C@@](C#C)(c1csc(NC(N)=O)n1)c1ccc(Br)cc1 |r| InChI=1S/C14H12BrN3OS/c1-3-14(2,9-4-6-10(15)7-5-9)11-8-20-13(17-11)18-12(16)19/h1,4-8H,2H3,(H3,16,17,18,19) DOSZECKMPIEVMN-UHFFFAOYSA-N 662251 (R)-1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A164::US20240226094, Compound A164::US20250241908, Compound A164::US20250381196, Compound A164 Alpha-protein kinase 1 Homo sapiens 17.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662251 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662251&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407496 496710710 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120065 CC(C#C)(c1csc(NC(=O)N2CC(CO)C2)n1)c1ccc(Br)cc1 InChI=1S/C18H18BrN3O2S/c1-3-18(2,13-4-6-14(19)7-5-13)15-11-25-16(20-15)21-17(24)22-8-12(9-22)10-23/h1,4-7,11-12,23H,8-10H2,2H3,(H,20,21,24) AUBUCWFNYBWRNW-UHFFFAOYSA-N 662252 N-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (hydroxymethyl)azetidine- 1-carboxamide::US20240109853, Compound A165::US20240226094, Compound A165::US20250241908, Compound A165::US20250381196, Compound A165 Alpha-protein kinase 1 Homo sapiens 138 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662252 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662252&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407814 496710711 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120066 C[C@](C#C)(c1csc(NC(=O)N2CC(CO)C2)n1)c1ccc(Br)cc1 |r| InChI=1S/C18H18BrN3O2S/c1-3-18(2,13-4-6-14(19)7-5-13)15-11-25-16(20-15)21-17(24)22-8-12(9-22)10-23/h1,4-7,11-12,23H,8-10H2,2H3,(H,20,21,24) AUBUCWFNYBWRNW-UHFFFAOYSA-N 662253 (R)-N-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (hydroxymethyl)azetidine- 1-carboxamide::US20240109853, Compound A166::US20240226094, Compound A166::US20250241908, Compound A166::US20250381196, Compound A166 Alpha-protein kinase 1 Homo sapiens 25.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662253&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407429 496710712 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120067 C[C@@](C#C)(c1csc(NC(=O)N2CC(CO)C2)n1)c1ccc(Br)cc1 |r| InChI=1S/C18H18BrN3O2S/c1-3-18(2,13-4-6-14(19)7-5-13)15-11-25-16(20-15)21-17(24)22-8-12(9-22)10-23/h1,4-7,11-12,23H,8-10H2,2H3,(H,20,21,24) AUBUCWFNYBWRNW-UHFFFAOYSA-N 662254 (S)-N-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (hydroxymethyl)azetidine- 1-carboxamide::US20240109853, Compound A167::US20240226094, Compound A167::US20250241908, Compound A167::US20250381196, Compound A167 Alpha-protein kinase 1 Homo sapiens 7.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662254 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662254&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407557 496710713 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120068 COc1ccc(cc1)C(C)(C#C)c1csc(NC(=O)NCCO)n1 InChI=1S/C17H19N3O3S/c1-4-17(2,12-5-7-13(23-3)8-6-12)14-11-24-16(19-14)20-15(22)18-9-10-21/h1,5-8,11,21H,9-10H2,2-3H3,(H2,18,19,20,22) MIZPFGQQPZZFJB-UHFFFAOYSA-N 662255 1-(2-hydroxyethyl)-3- (4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)urea::US20240109853, Compound A168::US20240226094, Compound A168::US20250241908, Compound A168::US20250381196, Compound A168 Alpha-protein kinase 1 Homo sapiens 27.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662255&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407643 496710714 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120069 COc1ccc(cc1)[C@@](C)(C#C)c1csc(NC(=O)NCCO)n1 |r| InChI=1S/C17H19N3O3S/c1-4-17(2,12-5-7-13(23-3)8-6-12)14-11-24-16(19-14)20-15(22)18-9-10-21/h1,5-8,11,21H,9-10H2,2-3H3,(H2,18,19,20,22) MIZPFGQQPZZFJB-UHFFFAOYSA-N 662256 (R)-1-(2-hydroxyethyl)- 3-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)urea::US20240109853, Compound A169::US20240226094, Compound A169::US20250241908, Compound A169::US20250381196, Compound A169 Alpha-protein kinase 1 Homo sapiens 23.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662256&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407588 496710715 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120070 COc1ccc(cc1)[C@](C)(C#C)c1csc(NC(=O)NCCO)n1 |r| InChI=1S/C17H19N3O3S/c1-4-17(2,12-5-7-13(23-3)8-6-12)14-11-24-16(19-14)20-15(22)18-9-10-21/h1,5-8,11,21H,9-10H2,2-3H3,(H2,18,19,20,22) MIZPFGQQPZZFJB-UHFFFAOYSA-N 662257 (S)-1-(2-hydroxyethyl)- 3-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)urea::US20240109853, Compound A170::US20240226094, Compound A170::US20250241908, Compound A170::US20250381196, Compound A170 Alpha-protein kinase 1 Homo sapiens 8.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662257&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407392 496710716 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120071 COc1ccc(cc1)C(C)(C#C)c1csc(NC(N)=O)n1 InChI=1S/C15H15N3O2S/c1-4-15(2,10-5-7-11(20-3)8-6-10)12-9-21-14(17-12)18-13(16)19/h1,5-9H,2-3H3,(H3,16,17,18,19) WWLSVGXVGZGYSA-UHFFFAOYSA-N 662258 1-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)urea::US20240109853, Compound A171::US20240226094, Compound A171::US20250241908, Compound A171::US20250381196, Compound A171 Alpha-protein kinase 1 Homo sapiens 16.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662258 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662258&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407757 496710717 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120072 COc1ccc(cc1)[C@@](C)(C#C)c1csc(NC(N)=O)n1 |r| InChI=1S/C15H15N3O2S/c1-4-15(2,10-5-7-11(20-3)8-6-10)12-9-21-14(17-12)18-13(16)19/h1,5-9H,2-3H3,(H3,16,17,18,19) WWLSVGXVGZGYSA-UHFFFAOYSA-N 662259 (R)-1-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)urea::US20240109853, Compound A172::US20240226094, Compound A172::US20250241908, Compound A172::US20250381196, Compound A172 Alpha-protein kinase 1 Homo sapiens 36.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662259 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662259&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407637 496710718 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120073 COc1ccc(cc1)[C@](C)(C#C)c1csc(NC(N)=O)n1 |r| InChI=1S/C15H15N3O2S/c1-4-15(2,10-5-7-11(20-3)8-6-10)12-9-21-14(17-12)18-13(16)19/h1,5-9H,2-3H3,(H3,16,17,18,19) WWLSVGXVGZGYSA-UHFFFAOYSA-N 662260 (S)-1-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)urea::US20240109853, Compound A173::US20240226094, Compound A173::US20250241908, Compound A173::US20250381196, Compound A173 Alpha-protein kinase 1 Homo sapiens 8.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662260&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407626 496710719 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120074 CC(C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(Cl)cc1 InChI=1S/C16H16ClN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22) IQPXNEQCZAHNPG-UHFFFAOYSA-N 662261 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A174::US20240226094, Compound A174::US20250241908, Compound A174::US20250381196, Compound A174 Alpha-protein kinase 1 Homo sapiens 34.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662261 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662261&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407596 496710720 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120075 C[C@](C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C16H16ClN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22) IQPXNEQCZAHNPG-UHFFFAOYSA-N 662262 US20240109853, Compound A320::US20240109853, Compound A300::(R)-1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A175::US20240226094, Compound A325::US20250241908, Compound A175::US20250381196, Compound A175 Alpha-protein kinase 1 Homo sapiens 32.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662262 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662262&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407741 496710721 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120076 C[C@@](C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C16H16ClN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22) IQPXNEQCZAHNPG-UHFFFAOYSA-N 662263 US20240109853, Compound A299::US20240109853, Compound A321::(S)-1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A176::US20240226094, Compound A326::US20250381196, Compound A176 Alpha-protein kinase 1 Homo sapiens 5.40 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662263 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662263&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407788 496710722 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120077 CC(C)(c1csc(NC(=O)NCCN2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C19H26BrN5OS/c1-19(2,14-3-5-15(20)6-4-14)16-13-27-18(23-16)24-17(26)22-9-12-25-10-7-21-8-11-25/h3-6,13,21H,7-12H2,1-2H3,(H2,22,23,24,26) PVXRYUWHJPZKPP-UHFFFAOYSA-N 662264 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(2- (piperazin-1- yl)ethyl)urea::US20240109853, Compound A177::US20240226094, Compound A177::US20250241908, Compound A177::US20250381196, Compound A177 Alpha-protein kinase 1 Homo sapiens 249 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662264&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407651 496710723 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120078 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1)c1ccc(I)cc1 InChI=1S/C22H26IN7OS/c1-22(2,16-3-5-17(23)6-4-16)18-14-32-21(28-18)29-20(31)27-13-15-11-25-19(26-12-15)30-9-7-24-8-10-30/h3-6,11-12,14,24H,7-10,13H2,1-2H3,(H2,27,28,29,31) OCEFQLVHEMRZLT-UHFFFAOYSA-N 662265 1-(4-(2-(4- iodophenyl)propan-2- yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A178::US20240226094, Compound A178::US20250241908, Compound A178::US20250381196, Compound A178 Alpha-protein kinase 1 Homo sapiens 42.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662265 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662265&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407552 496710724 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120079 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1)c1ccc(Cl)c(F)c1 InChI=1S/C22H25ClFN7OS/c1-22(2,15-3-4-16(23)17(24)9-15)18-13-33-21(29-18)30-20(32)28-12-14-10-26-19(27-11-14)31-7-5-25-6-8-31/h3-4,9-11,13,25H,5-8,12H2,1-2H3,(H2,28,29,30,32) HMEOMUAWZPYYIQ-UHFFFAOYSA-N 662266 1-(4-(2-(4-chloro-3- fluorophenyl)propan-2- yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A179::US20240226094, Compound A179::US20250241908, Compound A179::US20250381196, Compound A179 Alpha-protein kinase 1 Homo sapiens 95.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662266 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662266&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407461 496710725 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120080 Brc1ccc(cc1)C1(CCCC1)c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1 InChI=1S/C24H28BrN7OS/c25-19-5-3-18(4-6-19)24(7-1-2-8-24)20-16-34-23(30-20)31-22(33)29-15-17-13-27-21(28-14-17)32-11-9-26-10-12-32/h3-6,13-14,16,26H,1-2,7-12,15H2,(H2,29,30,31,33) RGDUNKQEWHVAPO-UHFFFAOYSA-N 662267 1-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A180::US20240226094, Compound A180::US20250241908, Compound A180::US20250381196, Compound A180 Alpha-protein kinase 1 Homo sapiens 45.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662267 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662267&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407480 496710726 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120081 CC(C)(c1csc(NC(=O)NCc2ccnc(c2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C23H27BrN6OS/c1-23(2,17-3-5-18(24)6-4-17)19-15-32-22(28-19)29-21(31)27-14-16-7-8-26-20(13-16)30-11-9-25-10-12-30/h3-8,13,15,25H,9-12,14H2,1-2H3,(H2,27,28,29,31) QMZNWYAWKFYHQX-UHFFFAOYSA-N 662268 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2- (piperazin-1-yl)pyridin- 4-yl)methyl)urea::US20240109853, Compound A181::US20240226094, Compound A181::US20250241908, Compound A181::US20250381196, Compound A181 Alpha-protein kinase 1 Homo sapiens 131 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662268&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407559 496710727 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120082 CC(C)(c1csc(NC(=O)NCc2cccc(n2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C23H27BrN6OS/c1-23(2,16-6-8-17(24)9-7-16)19-15-32-22(28-19)29-21(31)26-14-18-4-3-5-20(27-18)30-12-10-25-11-13-30/h3-9,15,25H,10-14H2,1-2H3,(H2,26,28,29,31) KLGVWBPKMLUYGS-UHFFFAOYSA-N 662269 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((6- (piperazin-1-yl)pyridin- 2-yl)methyl)urea::US20240109853, Compound A182::US20240226094, Compound A182::US20250241908, Compound A182::US20250381196, Compound A182 Alpha-protein kinase 1 Homo sapiens 163 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662269 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662269&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407822 496710728 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120083 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(NCCN)cc2)n1 InChI=1S/C23H29N5O2S/c1-23(2,17-6-10-19(30-3)11-7-17)20-15-31-22(27-20)28-21(29)26-14-16-4-8-18(9-5-16)25-13-12-24/h4-11,15,25H,12-14,24H2,1-3H3,(H2,26,27,28,29) VYWOMYMQYCAEGB-UHFFFAOYSA-N 662270 1-(4-((2- aminoethyl)amino)ben- yzl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A183::US20240226094, Compound A183::US20250241908, Compound A183::US20250381196, Compound A183 Alpha-protein kinase 1 Homo sapiens 52.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662270&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407394 496710729 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120084 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)N2CCC(N)C2)n1 InChI=1S/C25H31N5O2S/c1-25(2,18-6-10-21(32-3)11-7-18)22-16-33-24(28-22)29-23(31)27-14-17-4-8-20(9-5-17)30-13-12-19(26)15-30/h4-11,16,19H,12-15,26H2,1-3H3,(H2,27,28,29,31) ZGZBOPDZVJYCKO-UHFFFAOYSA-N 662271 1-(4-(3- aminopyrrolidin-1- yl)benzyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A184::US20240226094, Compound A184::US20250241908, Compound A184::US20250381196, Compound A184 Alpha-protein kinase 1 Homo sapiens 242 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662271 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662271&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407795 496710730 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120085 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(c2)C(=O)N(C)C)n1 InChI=1S/C28H36N6O3S/c1-28(2,20-7-9-21(37-5)10-8-20)24-18-38-27(31-24)32-26(36)30-17-19-6-11-23(34-14-12-29-13-15-34)22(16-19)25(35)33(3)4/h6-11,16,18,29H,12-15,17H2,1-5H3,(H2,30,31,32,36) AMLCJZITFKRZGI-UHFFFAOYSA-N 662272 5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-N,N- dimethyl-2-(piperazin-1- yl)benzamide::US20240109853, Compound A185::US20240226094, Compound A185::US20250241908, Compound A185::US20250381196, Compound A185 Alpha-protein kinase 1 Homo sapiens 56.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662272 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662272&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407698 496710731 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120086 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(nc2)N2CCC(N)C2)n1 InChI=1S/C24H30N6O2S/c1-24(2,17-5-7-19(32-3)8-6-17)20-15-33-23(28-20)29-22(31)27-13-16-4-9-21(26-12-16)30-11-10-18(25)14-30/h4-9,12,15,18H,10-11,13-14,25H2,1-3H3,(H2,27,28,29,31) KHJDOQFZFBYJBK-UHFFFAOYSA-N 662273 US20240109853, Compound A199::1-((6-(3- aminopyrrolidin-1- yl)pyridin-3-yl)methyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A186::US20240226094, Compound A199::US20250241908, Compound A199::US20250381196, Compound A199 Alpha-protein kinase 1 Homo sapiens 19.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662273&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407385 496710732 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120087 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2)N2CCC(N)C2)n1 InChI=1S/C23H29N7O2S/c1-23(2,16-4-6-18(32-3)7-5-16)19-14-33-22(28-19)29-21(31)27-12-15-10-25-20(26-11-15)30-9-8-17(24)13-30/h4-7,10-11,14,17H,8-9,12-13,24H2,1-3H3,(H2,27,28,29,31) ALAAHADSWNOBDC-UHFFFAOYSA-N 662274 1-((2-(3- aminopyrrolidin-1- yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A187::US20240226094, Compound A187::US20250241908, Compound A187::US20250381196, Compound A187 Alpha-protein kinase 1 Homo sapiens 7.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662274 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662274&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407802 496710733 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120088 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCCN)c1 InChI=1S/C19H27N3O2S/c1-19(2,14-6-8-16(24-3)9-7-14)15-12-17(25-13-15)22-18(23)21-11-5-4-10-20/h6-9,12-13H,4-5,10-11,20H2,1-3H3,(H2,21,22,23) VTDSCCQLHMCLDV-UHFFFAOYSA-N 662275 1-(4-aminobutyl)-3-(4- (2-(4- methoxyphenyl)propan- 2-yl)thiophen-2-yl)urea::US20240109853, Compound A188::US20240226094, Compound A188::US20250241908, Compound A188::US20250381196, Compound A188 Alpha-protein kinase 1 Homo sapiens 59.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662275 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662275&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407670 496710734 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120089 CC(C)(c1csc(NC(=O)NCc2ccc(nc2)N2CCC(N)C2)n1)c1ccc(Br)cc1 InChI=1S/C23H27BrN6OS/c1-23(2,16-4-6-17(24)7-5-16)19-14-32-22(28-19)29-21(31)27-12-15-3-8-20(26-11-15)30-10-9-18(25)13-30/h3-8,11,14,18H,9-10,12-13,25H2,1-2H3,(H2,27,28,29,31) ADEFZXYCPRZPOG-UHFFFAOYSA-N 662276 1-((6-(3- aminopyrrolidin-1- yl)pyridin-3-yl)methyl)- 3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A189::US20240226094, Compound A189::US20250241908, Compound A189::US20250381196, Compound A189 Alpha-protein kinase 1 Homo sapiens 41.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662276&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407547 496710735 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120090 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCC2CC(N)C2)n1 |(9.52,3.97,;8.9,2.57,;7.36,2.41,;6.68,.99,;5.15,.83,;4.25,2.08,;4.87,3.49,;6.4,3.65,;2.71,1.92,;2.71,3.46,;1.38,2.69,;2.09,.51,;2.86,-.82,;1.83,-1.97,;.42,-1.34,;-.91,-2.11,;-2.25,-1.34,;-2.25,.2,;-3.58,-2.11,;-4.91,-1.34,;-6.25,-2.11,;-7.73,-1.71,;-8.13,-3.2,;-9.47,-3.97,;-6.65,-3.6,;.58,.19,)| InChI=1S/C19H26N4O2S/c1-19(2,13-4-6-15(25-3)7-5-13)16-11-26-18(22-16)23-17(24)21-10-12-8-14(20)9-12/h4-7,11-12,14H,8-10,20H2,1-3H3,(H2,21,22,23,24) JIFTYWYBYITTDL-UHFFFAOYSA-N 662277 1-((3- aminocyclobutyl)methyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A190::US20240226094, Compound A190::US20250241908, Compound A190::US20250381196, Compound A190 Alpha-protein kinase 1 Homo sapiens 458 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662277 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662277&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407839 496710736 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120091 NC1CCN(CC1)c1ccc(CNC(=O)Nc2nc(cs2)C2(CCCC2)c2ccc(Br)cc2)cc1 InChI=1S/C27H32BrN5OS/c28-21-7-5-20(6-8-21)27(13-1-2-14-27)24-18-35-26(31-24)32-25(34)30-17-19-3-9-23(10-4-19)33-15-11-22(29)12-16-33/h3-10,18,22H,1-2,11-17,29H2,(H2,30,31,32,34) LTHPAEJBGMXSKV-UHFFFAOYSA-N 662278 1-(4-(4-aminopiperidin- 1-yl)benzyl)-3-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl)urea::US20240109853, Compound A191::US20240226094, Compound A191::US20250241908, Compound A191::US20250381196, Compound A191 Alpha-protein kinase 1 Homo sapiens 80.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662278&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407436 496710737 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120092 Fc1cc(CNC(=O)Nc2nc(cs2)C2(CCCC2)c2ccc(Br)cc2)cc(F)c1N1CCNCC1 InChI=1S/C26H28BrF2N5OS/c27-19-5-3-18(4-6-19)26(7-1-2-8-26)22-16-36-25(32-22)33-24(35)31-15-17-13-20(28)23(21(29)14-17)34-11-9-30-10-12-34/h3-6,13-14,16,30H,1-2,7-12,15H2,(H2,31,32,33,35) AQRXPRVCAKJLGS-UHFFFAOYSA-N 662279 1-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl)-3-(3,5- difluoro-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A192::US20240226094, Compound A192::US20250241908, Compound A192::US20250381196, Compound A192 Alpha-protein kinase 1 Homo sapiens 106 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662279 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662279&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407517 496710738 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120093 NC1CCN(CC1)c1ncc(CNC(=O)Nc2nc(cs2)C2(CCCC2)c2ccc(Br)cc2)cn1 InChI=1S/C25H30BrN7OS/c26-19-5-3-18(4-6-19)25(9-1-2-10-25)21-16-35-24(31-21)32-23(34)30-15-17-13-28-22(29-14-17)33-11-7-20(27)8-12-33/h3-6,13-14,16,20H,1-2,7-12,15,27H2,(H2,30,31,32,34) NIKPHIOEUWMKKT-UHFFFAOYSA-N 662280 1-(4-(4-aminopiperidin- 1-yl)benzyl)-3-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl)urea::US20240109853, Compound A193::US20240226094, Compound A193::US20250241908, Compound A193::US20250381196, Compound A193 Alpha-protein kinase 1 Homo sapiens 15.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662280&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407594 496710739 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120094 CC1CN(CCN1)c1ccc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)cc1 InChI=1S/C25H30BrN5OS/c1-17-15-31(13-12-27-17)21-10-4-18(5-11-21)14-28-23(32)30-24-29-22(16-33-24)25(2,3)19-6-8-20(26)9-7-19/h4-11,16-17,27H,12-15H2,1-3H3,(H2,28,29,30,32) HXIGRNGOCSWDNA-UHFFFAOYSA-N 662281 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-(3- methylpiperazin-1- yl)benzyl)urea::US20240109853, Compound A194::US20240226094, Compound A194::US20250241908, Compound A194::US20250381196, Compound A194 Alpha-protein kinase 1 Homo sapiens 172 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662281&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407797 496710740 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120095 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCNC(=O)C2)n1)c1ccc(Br)cc1 InChI=1S/C24H26BrN5O2S/c1-24(2,17-5-7-18(25)8-6-17)20-15-33-23(28-20)29-22(32)27-13-16-3-9-19(10-4-16)30-12-11-26-21(31)14-30/h3-10,15H,11-14H2,1-2H3,(H,26,31)(H2,27,28,29,32) CIDFJYMOOSENTN-UHFFFAOYSA-N 662282 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4-(3- oxopiperazin-1- yl)benzyl)urea::US20240109853, Compound A195::US20240226094, Compound A195::US20250241908, Compound A195::US20250381196, Compound A195 Alpha-protein kinase 1 Homo sapiens 132 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662282 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662282&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407473 496710741 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120096 CC(C)(c1csc(NC(=O)NCc2cnc(nc2)N2CCNCC2)n1)c1ccc(Br)c(F)c1 InChI=1S/C22H25BrFN7OS/c1-22(2,15-3-4-16(23)17(24)9-15)18-13-33-21(29-18)30-20(32)28-12-14-10-26-19(27-11-14)31-7-5-25-6-8-31/h3-4,9-11,13,25H,5-8,12H2,1-2H3,(H2,28,29,30,32) XEWZNIRTFJGCFO-UHFFFAOYSA-N 662283 1-(4-(2-(4-bromo-3- fluorophenyl)propan-2- yl)thiazol-2-yl)-3-((2- (piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A196::US20240226094, Compound A196::US20250241908, Compound A196::US20250381196, Compound A196 Alpha-protein kinase 1 Homo sapiens 76.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662283&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407381 496710742 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120097 CC(C)(c1csc(NC(=O)NCc2ccc(N3CCCNCC3)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C25H29BrFN5OS/c1-25(2,18-5-7-19(26)8-6-18)22-16-34-24(30-22)31-23(33)29-15-17-4-9-21(20(27)14-17)32-12-3-10-28-11-13-32/h4-9,14,16,28H,3,10-13,15H2,1-2H3,(H2,29,30,31,33) YHTDUJZYCUXTJA-UHFFFAOYSA-N 662284 1-(4-(1,4-diazepan-1- yl)-3-fluorobenzyl)-3- (4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A197::US20240226094, Compound A197::US20250241908, Compound A197::US20250381196, Compound A197 Alpha-protein kinase 1 Homo sapiens 67.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662284 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662284&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407531 496710743 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120098 CC(C)(c1csc(NC(=O)NCc2ccc(NCCN)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C22H25BrFN5OS/c1-22(2,15-4-6-16(23)7-5-15)19-13-31-21(28-19)29-20(30)27-12-14-3-8-18(17(24)11-14)26-10-9-25/h3-8,11,13,26H,9-10,12,25H2,1-2H3,(H2,27,28,29,30) GGVBJUWLYPRMLK-UHFFFAOYSA-N 662285 1-(4-((2- aminoethyl)amino)-3- fluorobenzyl)-3-(4-(2- (4-bromophenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A198::US20250241908, Compound A198::US20250381196, Compound A198 Alpha-protein kinase 1 Homo sapiens 18.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662285 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662285&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407563 496710744 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120099 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(nc2)N2CCC(N)C2)n1 InChI=1S/C24H30N6O2S/c1-24(2,17-5-7-19(32-3)8-6-17)20-15-33-23(28-20)29-22(31)27-13-16-4-9-21(26-12-16)30-11-10-18(25)14-30/h4-9,12,15,18H,10-11,13-14,25H2,1-3H3,(H2,27,28,29,31) KHJDOQFZFBYJBK-UHFFFAOYSA-N 662273 US20240109853, Compound A199::1-((6-(3- aminopyrrolidin-1- yl)pyridin-3-yl)methyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A186::US20240226094, Compound A199::US20250241908, Compound A199::US20250381196, Compound A199 Alpha-protein kinase 1 Homo sapiens 34.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662273&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407385 496710732 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120100 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cn2)N2CCC(N)C2)n1 InChI=1S/C24H30N6O2S/c1-24(2,16-4-8-20(32-3)9-5-16)21-15-33-23(28-21)29-22(31)27-12-18-6-7-19(13-26-18)30-11-10-17(25)14-30/h4-9,13,15,17H,10-12,14,25H2,1-3H3,(H2,27,28,29,31) WQTNBMWBPKSMQE-UHFFFAOYSA-N 662287 1-((5-(3- aminopyrrolidin-1- yl)pyridin-2-yl)methyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A200::US20240226094, Compound A200::US20250241908, Compound A200::US20250381196, Compound A200 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662287 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662287&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407844 496710745 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120101 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cc(F)c(N3CCC(N)C3)c(F)c2)n1 InChI=1S/C25H29F2N5O2S/c1-25(2,16-4-6-18(34-3)7-5-16)21-14-35-24(30-21)31-23(33)29-12-15-10-19(26)22(20(27)11-15)32-9-8-17(28)13-32/h4-7,10-11,14,17H,8-9,12-13,28H2,1-3H3,(H2,29,30,31,33) OVTZYMDNDAGUMV-UHFFFAOYSA-N 662288 1-(4-(3- aminopyrrolidin-1-yl)- 3,5-difluorobenzyl)-3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A201::US20240226094, Compound A201::US20250241908, Compound A201::US20250381196, Compound A201 Alpha-protein kinase 1 Homo sapiens 25.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662288&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407634 496710746 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120102 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(NCCN)nc2)n1 InChI=1S/C22H28N6O2S/c1-22(2,16-5-7-17(30-3)8-6-16)18-14-31-21(27-18)28-20(29)26-13-15-4-9-19(25-12-15)24-11-10-23/h4-9,12,14H,10-11,13,23H2,1-3H3,(H,24,25)(H2,26,27,28,29) QJBOZOZGCAJOKY-UHFFFAOYSA-N 662289 1-((6-((2- aminoethyl)amino)pyridin- 3-yl)methyl)-3-(4-(2- (4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A202::US20240226094, Compound A202::US20250241908, Compound A202::US20250381196, Compound A202 Alpha-protein kinase 1 Homo sapiens 34.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662289 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662289&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407660 496710747 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120103 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(nc2)C(=O)NCCN)n1 InChI=1S/C23H28N6O3S/c1-23(2,16-5-7-17(32-3)8-6-16)19-14-33-22(28-19)29-21(31)27-13-15-4-9-18(26-12-15)20(30)25-11-10-24/h4-9,12,14H,10-11,13,24H2,1-3H3,(H,25,30)(H2,27,28,29,31) FAIGQVMZLHZXKQ-UHFFFAOYSA-N 662290 N-(2-aminoethyl)-5-((3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)picolin- amide::US20240109853, Compound A203::US20240226094, Compound A203::US20250241908, Compound A203::US20250381196, Compound A203 Alpha-protein kinase 1 Homo sapiens 94.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662290&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407398 496710748 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120104 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCC(N)CC2)n1)c1ccc(Br)cc1 InChI=1S/C25H30BrN5OS/c1-25(2,18-5-7-19(26)8-6-18)22-16-33-24(29-22)30-23(32)28-15-17-3-9-21(10-4-17)31-13-11-20(27)12-14-31/h3-10,16,20H,11-15,27H2,1-2H3,(H2,28,29,30,32) CMCOKFJMRNGPPY-UHFFFAOYSA-N 662291 1-(4-(4-aminopiperidin- 1-yl)benzyl)-3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A204::US20240226094, Compound A204::US20250241908, Compound A204::US20250381196, Compound A204 Alpha-protein kinase 1 Homo sapiens 9.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662291 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662291&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407453 496710749 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120105 CC(C)(c1csc(NC(=O)NCc2ccc(NCCN)cc2)n1)c1ccc(Br)cc1 InChI=1S/C22H26BrN5OS/c1-22(2,16-5-7-17(23)8-6-16)19-14-30-21(27-19)28-20(29)26-13-15-3-9-18(10-4-15)25-12-11-24/h3-10,14,25H,11-13,24H2,1-2H3,(H2,26,27,28,29) UEVVKHGYRQBWEX-UHFFFAOYSA-N 662292 1-(4-((2- aminoethyl)amino)ben- zyl)-3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A205::US20240226094, Compound A205::US20250241908, Compound A205::US20250381196, Compound A205 Alpha-protein kinase 1 Homo sapiens 59.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662292 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662292&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407640 496710750 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120106 CC(C)(c1csc(NC(=O)NCc2cnc(NCCN3CCNCC3)nc2)n1)c1ccc(Br)cc1 InChI=1S/C24H31BrN8OS/c1-24(2,18-3-5-19(25)6-4-18)20-16-35-23(31-20)32-22(34)30-15-17-13-28-21(29-14-17)27-9-12-33-10-7-26-8-11-33/h3-6,13-14,16,26H,7-12,15H2,1-2H3,(H,27,28,29)(H2,30,31,32,34) AAUKPMSSZDGEJQ-UHFFFAOYSA-N 662293 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((2- ((2-(piperazin-1- yl)ethyl)amino)pyrimidin- 5-yl)methyl)urea::US20240109853, Compound A206::US20240226094, Compound A206::US20250241908, Compound A206::US20250381196, Compound A206 Alpha-protein kinase 1 Homo sapiens 68.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662293&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407487 496710751 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120107 CC(C)(c1csc(NC(=O)NCc2ccnc(N3CCNCC3)c2F)n1)c1ccc(Br)cc1 InChI=1S/C23H26BrFN6OS/c1-23(2,16-3-5-17(24)6-4-16)18-14-33-22(29-18)30-21(32)28-13-15-7-8-27-20(19(15)25)31-11-9-26-10-12-31/h3-8,14,26H,9-13H2,1-2H3,(H2,28,29,30,32) DOZCBXUXHHLFPT-UHFFFAOYSA-N 662294 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-((3- fluoro-2-(piperazin-1- yl)pyridin-4- yl)methyl)urea::US20240109853, Compound A207::US20240226094, Compound A207::US20250241908, Compound A207::US20250381196, Compound A207 Alpha-protein kinase 1 Homo sapiens 99.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662294&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407853 496710752 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120108 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2)N2CCN(CCO)CC2)n1 InChI=1S/C25H33N7O3S/c1-25(2,19-4-6-20(35-3)7-5-19)21-17-36-24(29-21)30-23(34)28-16-18-14-26-22(27-15-18)32-10-8-31(9-11-32)12-13-33/h4-7,14-15,17,33H,8-13,16H2,1-3H3,(H2,28,29,30,34) DXCKHLIJBNJKJP-UHFFFAOYSA-N 662295 1-((2-(4-(2- hydroxyethyl)piperazin- 1-yl)pyrimidin-5- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A208::US20240226094, Compound A208::US20250241908, Compound A208::US20250381196, Compound A208 Alpha-protein kinase 1 Homo sapiens 78.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662295&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407403 496710753 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120109 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(N3CCNCC3)c(c2)C(N)=O)n1 InChI=1S/C25H31N7O3S/c1-25(2,17-4-6-18(35-3)7-5-17)20-15-36-24(30-20)31-23(34)29-14-16-12-19(21(26)33)22(28-13-16)32-10-8-27-9-11-32/h4-7,12-13,15,27H,8-11,14H2,1-3H3,(H2,26,33)(H2,29,30,31,34) PXTILERPDWYFON-UHFFFAOYSA-N 662296 5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)-2- (piperazin-1- yl)nicotinamide::US20240109853, Compound A209::US20250241908, Compound A209::US20250381196, Compound A209 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662296 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662296&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407460 496710754 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120110 CC(C)(c1csc(NC(=O)NCCN)n1)c1ccc(Br)cc1 InChI=1S/C15H19BrN4OS/c1-15(2,10-3-5-11(16)6-4-10)12-9-22-14(19-12)20-13(21)18-8-7-17/h3-6,9H,7-8,17H2,1-2H3,(H2,18,19,20,21) CYRDENFXODIHJK-UHFFFAOYSA-N 662297 1-(2-aminoethyl)-3-(4- (2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A210::US20240226094, Compound A210::US20250241908, Compound A210::US20250381196, Compound A210 Alpha-protein kinase 1 Homo sapiens 95.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662297&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407546 496710755 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120111 CC(C)(c1csc(NC(=O)NCc2ccc(cc2)N2CCC(CN)CC2)n1)c1ccc(Br)cc1 InChI=1S/C26H32BrN5OS/c1-26(2,20-5-7-21(27)8-6-20)23-17-34-25(30-23)31-24(33)29-16-19-3-9-22(10-4-19)32-13-11-18(15-28)12-14-32/h3-10,17-18H,11-16,28H2,1-2H3,(H2,29,30,31,33) HFAPVKYKGIMCBM-UHFFFAOYSA-N 662298 1-(4-(4- (aminomethyl)piperidin- 1-yl)benzyl)-3-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A211::US20240226094, Compound A211::US20250241908, Compound A211::US20250381196, Compound A211 Alpha-protein kinase 1 Homo sapiens 94.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662298 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662298&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407657 496710756 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120112 CC(C)(c1csc(NC(=O)NCc2ccc(OCCN)cc2)n1)c1ccc(Br)cc1 InChI=1S/C22H25BrN4O2S/c1-22(2,16-5-7-17(23)8-6-16)19-14-30-21(26-19)27-20(28)25-13-15-3-9-18(10-4-15)29-12-11-24/h3-10,14H,11-13,24H2,1-2H3,(H2,25,26,27,28) NVPPCCJMHKNTCG-UHFFFAOYSA-N 662299 1-(4-(2- aminoethoxy)benzyl)-3- (4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)urea::US20240109853, Compound A212::US20240226094, Compound A212::US20250241908, Compound A212::US20250381196, Compound A212 Alpha-protein kinase 1 Homo sapiens 289 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662299 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662299&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407490 496710757 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120113 CC1CN(CC(C)N1)c1ccc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)cc1 InChI=1S/C26H32BrN5OS/c1-17-14-32(15-18(2)29-17)22-11-5-19(6-12-22)13-28-24(33)31-25-30-23(16-34-25)26(3,4)20-7-9-21(27)10-8-20/h5-12,16-18,29H,13-15H2,1-4H3,(H2,28,30,31,33) ARNHZDBPMUAGDD-UHFFFAOYSA-N 662300 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(4- (3,5-dimethylpiperazin- 1-yl)benzyl)urea::US20240109853, Compound A213::US20240226094, Compound A213::US20250241908, Compound A213::US20250381196, Compound A213 Alpha-protein kinase 1 Homo sapiens 9.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662300 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662300&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407509 496710758 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120114 CC(C)(c1csc(NC(=O)NCc2ccc(CN3CCNCC3)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C25H29BrFN5OS/c1-25(2,19-5-7-20(26)8-6-19)22-16-34-24(30-22)31-23(33)29-14-17-3-4-18(21(27)13-17)15-32-11-9-28-10-12-32/h3-8,13,16,28H,9-12,14-15H2,1-2H3,(H2,29,30,31,33) XRDAOARSPBWOGK-UHFFFAOYSA-N 662301 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- fluoro-4-(piperazin-1- ylmethyl)benzyl)urea::US20240109853, Compound A214::US20240226094, Compound A214::US20250241908, Compound A214::US20250381196, Compound A214 Alpha-protein kinase 1 Homo sapiens 40.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662301 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662301&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407378 496710759 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120115 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2)N2CCC(CC2)C(N)=O)n1 InChI=1S/C25H31N7O3S/c1-25(2,18-4-6-19(35-3)7-5-18)20-15-36-24(30-20)31-23(34)29-14-16-12-27-22(28-13-16)32-10-8-17(9-11-32)21(26)33/h4-7,12-13,15,17H,8-11,14H2,1-3H3,(H2,26,33)(H2,29,30,31,34) WDGAFKVQYXOTDC-UHFFFAOYSA-N 662302 1-(5-((3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)pyrimi- din-2-yl)piperidine-4- carboxamide::US20240109853, Compound A215::US20240226094, Compound A215::US20250241908, Compound A215::US20250381196, Compound A215 Alpha-protein kinase 1 Homo sapiens 150 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662302 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662302&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407624 496710760 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120116 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(N3CCN(CCO)CC3)c(F)c2)n1 InChI=1S/C26H33FN6O3S/c1-26(2,19-4-6-20(36-3)7-5-19)22-17-37-25(30-22)31-24(35)29-16-18-14-21(27)23(28-15-18)33-10-8-32(9-11-33)12-13-34/h4-7,14-15,17,34H,8-13,16H2,1-3H3,(H2,29,30,31,35) HMVNRSUFPDSCJW-UHFFFAOYSA-N 662303 1-((5-fluoro-6-(4-(2- hydroxyethyl)piperazin- 1-yl)pyridin-3- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A216::US20240226094, Compound A216::US20250241908, Compound A216::US20250381196, Compound A216 Alpha-protein kinase 1 Homo sapiens 61.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662303 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662303&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407464 496710761 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120117 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(nc2)C(=O)N2CCC(N)C2)n1 InChI=1S/C25H30N6O3S/c1-25(2,17-5-7-19(34-3)8-6-17)21-15-35-24(29-21)30-23(33)28-13-16-4-9-20(27-12-16)22(32)31-11-10-18(26)14-31/h4-9,12,15,18H,10-11,13-14,26H2,1-3H3,(H2,28,29,30,33) AUQWTFUVQCRMJB-UHFFFAOYSA-N 662304 1-((6-(3- aminopyrrolidine-1- carbonyl)pyridin-3- yl)methyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A217::US20240226094, Compound A217::US20250241908, Compound A217::US20250381196, Compound A217 Alpha-protein kinase 1 Homo sapiens 56.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662304 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662304&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407694 496710762 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120118 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(cc2)C(=O)NCCN)n1 InChI=1S/C24H29N5O3S/c1-24(2,18-8-10-19(32-3)11-9-18)20-15-33-23(28-20)29-22(31)27-14-16-4-6-17(7-5-16)21(30)26-13-12-25/h4-11,15H,12-14,25H2,1-3H3,(H,26,30)(H2,27,28,29,31) TYTPOGMHGUVXHH-UHFFFAOYSA-N 662305 N-(2-aminoethyl)-4-((3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2- yl)ureido)methyl)benza- mide::US20240109853, Compound A218::US20240226094, Compound A218::US20250241908, Compound A218::US20250381196, Compound A218 Alpha-protein kinase 1 Homo sapiens 29.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662305 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662305&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171665626 496710763 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120119 CC(C)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(Cl)c2)n1)c1ccc(Br)cc1 InChI=1S/C24H27BrClN5OS/c1-24(2,17-4-6-18(25)7-5-17)21-15-33-23(29-21)30-22(32)28-14-16-3-8-20(19(26)13-16)31-11-9-27-10-12-31/h3-8,13,15,27H,9-12,14H2,1-2H3,(H2,28,29,30,32) OCDKXODUMMWVQO-UHFFFAOYSA-N 662306 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- chloro-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A219::US20240226094, Compound A219::US20250241908, Compound A219::US20250381196, Compound A219 Alpha-protein kinase 1 Homo sapiens 46.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662306 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662306&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407548 496710764 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120120 COc1cc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)ccc1N1CCNCC1 InChI=1S/C25H30BrN5O2S/c1-25(2,18-5-7-19(26)8-6-18)22-16-34-24(29-22)30-23(32)28-15-17-4-9-20(21(14-17)33-3)31-12-10-27-11-13-31/h4-9,14,16,27H,10-13,15H2,1-3H3,(H2,28,29,30,32) CYZORXWJIWPIDC-UHFFFAOYSA-N 662307 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- methoxy-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A220::US20240226094, Compound A220::US20250241908, Compound A220::US20250381196, Compound A220 Alpha-protein kinase 1 Homo sapiens 44.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662307 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662307&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407740 496710765 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120121 CC(C)Oc1cc(CNC(=O)Nc2nc(cs2)C(C)(C)c2ccc(Br)cc2)ccc1N1CCNCC1 InChI=1S/C27H34BrN5O2S/c1-18(2)35-23-15-19(5-10-22(23)33-13-11-29-12-14-33)16-30-25(34)32-26-31-24(17-36-26)27(3,4)20-6-8-21(28)9-7-20/h5-10,15,17-18,29H,11-14,16H2,1-4H3,(H2,30,31,32,34) YEEHPNMDKUHPKM-UHFFFAOYSA-N 662308 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- isopropoxy-4- (piperazin-1- yl)benzyl)urea::US20240109853, Compound A221::US20240226094, Compound A221::US20250241908, Compound A221::US20250381196, Compound A221 Alpha-protein kinase 1 Homo sapiens 144 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662308 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662308&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407599 496710766 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120122 CC(C)(c1csc(NC(=O)NCc2ccc(C3CCNCC3)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C25H28BrFN4OS/c1-25(2,18-4-6-19(26)7-5-18)22-15-33-24(30-22)31-23(32)29-14-16-3-8-20(21(27)13-16)17-9-11-28-12-10-17/h3-8,13,15,17,28H,9-12,14H2,1-2H3,(H2,29,30,31,32) PUDLYKZMRJPOFH-UHFFFAOYSA-N 662309 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3- fluoro-4-(piperidin-4- yl)benzyl)urea::US20240109853, Compound A222::US20240226094, Compound A222::US20250241908, Compound A222::US20250381196, Compound A222 Alpha-protein kinase 1 Homo sapiens 56.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662309 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662309&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407766 496710767 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120123 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cnc(nc2C)N2CCNCC2)n1 InChI=1S/C24H31N7O2S/c1-16-17(13-26-21(28-16)31-11-9-25-10-12-31)14-27-22(32)30-23-29-20(15-34-23)24(2,3)18-5-7-19(33-4)8-6-18/h5-8,13,15,25H,9-12,14H2,1-4H3,(H2,27,29,30,32) BDCBXOJGIZTAHM-UHFFFAOYSA-N 662310 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-((4- methyl-2-(piperazin-1- yl)pyrimidin-5- yl)methyl)urea::US20240109853, Compound A223::US20240226094, Compound A223::US20250241908, Compound A223::US20250381196, Compound A223 Alpha-protein kinase 1 Homo sapiens 49.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662310 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662310&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407501 496710768 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120124 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(C3CCNCC3)c(F)c2)n1 InChI=1S/C26H31FN4O2S/c1-26(2,19-5-7-20(33-3)8-6-19)23-16-34-25(30-23)31-24(32)29-15-17-4-9-21(22(27)14-17)18-10-12-28-13-11-18/h4-9,14,16,18,28H,10-13,15H2,1-3H3,(H2,29,30,31,32) CZDKBIUJTXNLHI-UHFFFAOYSA-N 662311 1-(3-fluoro-4-(piperidin- 4-yl)benzyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A224::US20240226094, Compound A224::US20250241908, Compound A224::US20250381196, Compound A224 Alpha-protein kinase 1 Homo sapiens 21.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662311 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662311&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407681 496710769 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120125 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(OC(C)C)c2)n1 InChI=1S/C28H37N5O3S/c1-19(2)36-24-16-20(6-11-23(24)33-14-12-29-13-15-33)17-30-26(34)32-27-31-25(18-37-27)28(3,4)21-7-9-22(35-5)10-8-21/h6-11,16,18-19,29H,12-15,17H2,1-5H3,(H2,30,31,32,34) DWOSDEBTZQLZTI-UHFFFAOYSA-N 662312 1-(3-isopropoxy-4- (piperazin-1-yl)benzyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A225::US20240226094, Compound A225::US20250241908, Compound A225::US20250381196, Compound A225 Alpha-protein kinase 1 Homo sapiens 108 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662312 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662312&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407407 496710770 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120126 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCN2CCC(N)C2)n1 InChI=1S/C21H31N5O2S/c1-21(2,15-5-7-17(28-3)8-6-15)18-14-29-20(24-18)25-19(27)23-10-4-11-26-12-9-16(22)13-26/h5-8,14,16H,4,9-13,22H2,1-3H3,(H2,23,24,25,27) KKVJRBRNCFKHDX-UHFFFAOYSA-N 662313 1-(3-(3- aminopyrrolidin-1- yl)propyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A226::US20240226094, Compound A226::US20250241908, Compound A226::US20250381196, Compound A226 Alpha-protein kinase 1 Homo sapiens 100.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662313&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407825 496710771 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120127 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCN2CCC(N)C2)n1 InChI=1S/C20H29N5O2S/c1-20(2,14-4-6-16(27-3)7-5-14)17-13-28-19(23-17)24-18(26)22-9-11-25-10-8-15(21)12-25/h4-7,13,15H,8-12,21H2,1-3H3,(H2,22,23,24,26) WTSRCZYYIHCEKK-UHFFFAOYSA-N 662314 1-(2-(3- aminopyrrolidin-1- yl)ethyl)-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A227::US20240226094, Compound A227::US20250241908, Compound A227::US20250381196, Compound A227 Alpha-protein kinase 1 Homo sapiens 138 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662314&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407836 496710772 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120128 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCN2CCNC(C)C2)n1 InChI=1S/C22H33N5O2S/c1-16-14-27(13-11-23-16)12-5-10-24-20(28)26-21-25-19(15-30-21)22(2,3)17-6-8-18(29-4)9-7-17/h6-9,15-16,23H,5,10-14H2,1-4H3,(H2,24,25,26,28) HFLBIMINPFURLH-UHFFFAOYSA-N 662315 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(3- (3-methylpiperazin-1- yl)propyl)urea::US20240109853, Compound A228::US20240226094, Compound A228::US20250241908, Compound A228::US20250381196, Compound A228 Alpha-protein kinase 1 Homo sapiens 100.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662315&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407840 496710773 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120129 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCS(=O)(=O)N2CCC(N)C2)n1 InChI=1S/C21H31N5O4S2/c1-21(2,15-5-7-17(30-3)8-6-15)18-14-31-20(24-18)25-19(27)23-10-4-12-32(28,29)26-11-9-16(22)13-26/h5-8,14,16H,4,9-13,22H2,1-3H3,(H2,23,24,25,27) BQVVLMUMFDHEHS-UHFFFAOYSA-N 662316 1-(3-((3- aminopyrrolidin-1- yl)sulfonyl)propyl)-3- (4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A229::US20240226094, Compound A229::US20250241908, Compound A229::US20250381196, Compound A229 Alpha-protein kinase 1 Homo sapiens 169 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662316 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662316&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407526 496710774 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120130 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCCCS(=O)(=O)N2CCNCC2)n1 InChI=1S/C21H31N5O4S2/c1-21(2,16-5-7-17(30-3)8-6-16)18-15-31-20(24-18)25-19(27)23-9-4-14-32(28,29)26-12-10-22-11-13-26/h5-8,15,22H,4,9-14H2,1-3H3,(H2,23,24,25,27) KFNUIPZKZUCXCH-UHFFFAOYSA-N 662317 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(3- (piperazin-1- ylsulfonyl)propyl)urea::US20240109853, Compound A230::US20240226094, Compound A230::US20250241908, Compound A230::US20250381196, Compound A230 Alpha-protein kinase 1 Homo sapiens 127 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662317 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662317&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407722 496710775 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120131 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cc(F)c(cc2F)N2CCNCC2)n1 InChI=1S/C25H29F2N5O2S/c1-25(2,17-4-6-18(34-3)7-5-17)22-15-35-24(30-22)31-23(33)29-14-16-12-20(27)21(13-19(16)26)32-10-8-28-9-11-32/h4-7,12-13,15,28H,8-11,14H2,1-3H3,(H2,29,30,31,33) JLVXBINKWSNMNA-UHFFFAOYSA-N 662318 1-(2,5-difluoro-4- (piperazin-1-yl)benzyl)- 3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea hydrochloride::US20240109853, Compound A231::US20240226094, Compound A231::US20250241908, Compound A231::US20250381196, Compound A231 Alpha-protein kinase 1 Homo sapiens 27.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662318 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662318&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407525 496710776 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120132 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NCc2cc(F)c(N3CC4CC(C3)N4)c(F)c2)n1 InChI=1S/C26H29F2N5O2S/c1-26(2,16-4-6-19(35-3)7-5-16)22-14-36-25(31-22)32-24(34)29-11-15-8-20(27)23(21(28)9-15)33-12-17-10-18(13-33)30-17/h4-9,14,17-18,30H,10-13H2,1-3H3,(H2,29,31,32,34) LUVCNPREZUEDHP-UHFFFAOYSA-N 662319 1-4-(3,6- diazabicyclo[3.1.1]heptan- 3-yl)-3,5- difluorobenzyl)-3-(4-(2- (4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A232::US20240226094, Compound A232::US20250241908, Compound A232::US20250381196, Compound A232 Alpha-protein kinase 1 Homo sapiens 88.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662319 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662319&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407500 496710777 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120133 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)N2CC(C2)c2ccc(cc2)N2CCNCC2)n1 InChI=1S/C27H33N5O2S/c1-27(2,21-6-10-23(34-3)11-7-21)24-18-35-25(29-24)30-26(33)32-16-20(17-32)19-4-8-22(9-5-19)31-14-12-28-13-15-31/h4-11,18,20,28H,12-17H2,1-3H3,(H,29,30,33) YFVWZBOVAVVAJZ-UHFFFAOYSA-N 662320 N-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)phenyl)azetidine-1- carboxamide::US20240109853, Compound A233::US20240226094, Compound A233::US20250241908, Compound A233::US20250381196, Compound A233 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662320 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662320&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407823 496710778 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120134 COc1ccc(cc1)C(C)(C#C)c1csc(NC(=O)NC(C)c2ccc(cc2)N2CCNCC2)n1 InChI=1S/C27H31N5O2S/c1-5-27(3,21-8-12-23(34-4)13-9-21)24-18-35-26(30-24)31-25(33)29-19(2)20-6-10-22(11-7-20)32-16-14-28-15-17-32/h1,6-13,18-19,28H,14-17H2,2-4H3,(H2,29,30,31,33) QLAVOXWIRSDWNN-UHFFFAOYSA-N 662321 1-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2-yl)-3- (1-(4-(piperazin-1- yl)phenyl)ethyl)urea::US20240109853, Compound A234::US20240226094, Compound A234::US20250241908, Compound A234::US20250381196, Compound A234 Alpha-protein kinase 1 Homo sapiens 36.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662321 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662321&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221917 496710779 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120135 COc1ccc(cc1)C(C)(CO)c1csc(NC(=O)NC(C)c2ccc(cc2)N2CCNCC2)n1 InChI=1S/C26H33N5O3S/c1-18(19-4-8-21(9-5-19)31-14-12-27-13-15-31)28-24(33)30-25-29-23(16-35-25)26(2,17-32)20-6-10-22(34-3)11-7-20/h4-11,16,18,27,32H,12-15,17H2,1-3H3,(H2,28,29,30,33) XWWSHTZYVXVMIL-UHFFFAOYSA-N 662322 1-(4-(1-hydroxy-2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(1- (4-(piperazin-1- yl)phenyl)ethyl)urea::US20240109853, Compound A235::US20240226094, Compound A235::US20250241908, Compound A235::US20250381196, Compound A235 Alpha-protein kinase 1 Homo sapiens 61.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662322 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662322&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221921 496710780 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120136 Fc1cc(ccc1N1CCNCC1)C1CN(C1)C(=O)Nc1nc(cs1)C1(CCCC1)c1ccc(Br)cc1 InChI=1S/C28H31BrFN5OS/c29-22-6-4-21(5-7-22)28(9-1-2-10-28)25-18-37-26(32-25)33-27(36)35-16-20(17-35)19-3-8-24(23(30)15-19)34-13-11-31-12-14-34/h3-8,15,18,20,31H,1-2,9-14,16-17H2,(H,32,33,36) QFCBQYKBEOKLJH-UHFFFAOYSA-N 662323 N-(4-(1-(4- bromophenyl)cyclopent- yl)thiazol-2-yl)-3-(3- fluoro-4-(piperazin-1- yl)phenyl)azetidine-1- carboxamide::US20240109853, Compound A236::US20240226094, Compound A236::US20250241908, Compound A236::US20250381196, Compound A236 Alpha-protein kinase 1 Homo sapiens 13.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662323 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662323&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407848 496710781 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120137 CC(C#C)(c1csc(NC(=O)N2CC(C2)c2ccc(cc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C27H28BrN5OS/c1-3-27(2,21-6-8-22(28)9-7-21)24-18-35-25(30-24)31-26(34)33-16-20(17-33)19-4-10-23(11-5-19)32-14-12-29-13-15-32/h1,4-11,18,20,29H,12-17H2,2H3,(H,30,31,34) OATDIDMBBFFGOO-UHFFFAOYSA-N 662324 N-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)phenyl)azetidine-1- carboxamide::US20240109853, Compound A237::US20240226094, Compound A237::US20250241908, Compound A237::US20250381196, Compound A237 Alpha-protein kinase 1 Homo sapiens 7.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662324 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662324&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407758 496710782 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120138 CC(C#C)(c1csc(NC(=O)NCC2(O)CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C20H23BrN4O2S/c1-3-19(2,14-4-6-15(21)7-5-14)16-12-28-18(24-16)25-17(26)23-13-20(27)8-10-22-11-9-20/h1,4-7,12,22,27H,8-11,13H2,2H3,(H2,23,24,25,26) CSIMPSIHVFWDCH-UHFFFAOYSA-N 662325 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-((4- hydroxypiperidin-4- yl)methyl)urea::US20240109853, Compound A238::US20240226094, Compound A238::US20250241908, Compound A238::US20250381196, Compound A238 Alpha-protein kinase 1 Homo sapiens 19.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662325 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662325&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407452 496710783 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120139 CC(C#C)(c1csc(NC(=O)NCCN2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C20H24BrN5OS/c1-3-20(2,15-4-6-16(21)7-5-15)17-14-28-19(24-17)25-18(27)23-10-13-26-11-8-22-9-12-26/h1,4-7,14,22H,8-13H2,2H3,(H2,23,24,25,27) MDJKZUHGHQXLPV-UHFFFAOYSA-N 662326 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- (piperazin-1- yl)ethyl)urea::US20240109853, Compound A239::US20240226094, Compound A239::US20250241908, Compound A239::US20250381196, Compound A239 Alpha-protein kinase 1 Homo sapiens 20.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662326 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662326&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407482 496710784 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120140 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)NC2(CC2)c2ccc(cc2)N2CCNCC2)n1 InChI=1S/C27H33N5O2S/c1-26(2,19-6-10-22(34-3)11-7-19)23-18-35-25(29-23)30-24(33)31-27(12-13-27)20-4-8-21(9-5-20)32-16-14-28-15-17-32/h4-11,18,28H,12-17H2,1-3H3,(H2,29,30,31,33) QGHIQHKRLWJRMG-UHFFFAOYSA-N 662327 1-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-3-(1- (4-(piperazin-1- yl)phenyl)cyclopropyl)u- rea::US20240109853, Compound A240::US20240226094, Compound A240::US20250241908, Compound A240::US20250381196, Compound A240 Alpha-protein kinase 1 Homo sapiens 97.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662327 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662327&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407595 496710785 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120141 CCNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1 InChI=1S/C15H18BrN3OS/c1-4-17-13(20)19-14-18-12(9-21-14)15(2,3)10-5-7-11(16)8-6-10/h5-9H,4H2,1-3H3,(H2,17,18,19,20) MNJMZXMSTXYODS-UHFFFAOYSA-N 662328 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3- ethylurea::US20240109853, Compound A241::US20240226094, Compound A241::US20250241908, Compound A241::US20250381196, Compound A241 Alpha-protein kinase 1 Homo sapiens 98.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662328 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662328&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407523 496710786 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120142 CCNC(=O)Nc1nc(cs1)C(C)(C)c1ccc(OC)cc1 InChI=1S/C16H21N3O2S/c1-5-17-14(20)19-15-18-13(10-22-15)16(2,3)11-6-8-12(21-4)9-7-11/h6-10H,5H2,1-4H3,(H2,17,18,19,20) LJAZFFJDENAXSB-UHFFFAOYSA-N 662329 1-ethyl-3-(4-(2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A242::US20240226094, Compound A242::US20250241908, Compound A242::US20250381196, Compound A242 Alpha-protein kinase 1 Homo sapiens 42.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662329 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662329&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169096270 496710787 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120143 CC(C#C)(c1csc(NC(=O)NCCS(N)(=O)=O)n1)c1ccc(Cl)cc1 InChI=1S/C16H17ClN4O3S2/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-25-15(20-13)21-14(22)19-8-9-26(18,23)24/h1,4-7,10H,8-9H2,2H3,(H2,18,23,24)(H2,19,20,21,22) IWQSVWOJUIJSGQ-UHFFFAOYSA-N 662330 2-(3-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)ureido)ethane-1- sulfonamide::US20240109853, Compound A243::US20240226094, Compound A243::US20250241908, Compound A243::US20250381196, Compound A243 Alpha-protein kinase 1 Homo sapiens 23.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662330&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407593 496710788 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120144 CC(C#C)(c1csc(NC(=O)NCC(O)CO)n1)c1ccc(Cl)cc1 InChI=1S/C17H18ClN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-8-13(23)9-22/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) RIWKXPKOFLBNNF-UHFFFAOYSA-N 662331 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (2,3- dihydroxypropyl)urea::US20240109853, Compound A244::US20240226094, Compound A244::US20250241908, Compound A244::US20250381196, Compound A244 Alpha-protein kinase 1 Homo sapiens 72.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662331&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407767 496710789 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120145 C[C@@](C#C)(c1csc(NC(=O)N2CC(C2)c2ccc(N3CCNCC3)c(F)c2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C27H27ClFN5OS/c1-3-27(2,20-5-7-21(28)8-6-20)24-17-36-25(31-24)32-26(35)34-15-19(16-34)18-4-9-23(22(29)14-18)33-12-10-30-11-13-33/h1,4-9,14,17,19,30H,10-13,15-16H2,2H3,(H,31,32,35) FRNQWCMLTKXOGB-UHFFFAOYSA-N 662332 S)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(3- fluoro-4-(piperazin-1- yl)phenyl)azetidine-1- carboxamide::US20240109853, Compound A245::US20240226094, Compound A245::US20250241908, Compound A245::US20250381196, Compound A245 Alpha-protein kinase 1 Homo sapiens 16.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662332&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407604 496710790 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120146 C[C@](C#C)(c1csc(NC(=O)N2CC(C2)c2ccc(N3CCNCC3)c(F)c2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C27H27ClFN5OS/c1-3-27(2,20-5-7-21(28)8-6-20)24-17-36-25(31-24)32-26(35)34-15-19(16-34)18-4-9-23(22(29)14-18)33-12-10-30-11-13-33/h1,4-9,14,17,19,30H,10-13,15-16H2,2H3,(H,31,32,35) FRNQWCMLTKXOGB-UHFFFAOYSA-N 662333 (R)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(3- fluoro-4-(piperazin-1- yl)phenyl)azetidine-1- carboxamide::US20240109853, Compound A246::US20240226094, Compound A246::US20250241908, Compound A246::US20250381196, Compound A246 Alpha-protein kinase 1 Homo sapiens 29.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662333 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662333&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407709 496710791 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120147 C[C@@](C#C)(c1nc(NC(=O)NCCO)sc1Cl)c1ccc(Cl)cc1 |r| InChI=1S/C16H15Cl2N3O2S/c1-3-16(2,10-4-6-11(17)7-5-10)12-13(18)24-15(20-12)21-14(23)19-8-9-22/h1,4-7,22H,8-9H2,2H3,(H2,19,20,21,23) XTYLMGDADIAJEG-UHFFFAOYSA-N 662334 (S)-1-(5-chloro-4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A247::US20240226094, Compound A247::US20250241908, Compound A247::US20250381196, Compound A247 Alpha-protein kinase 1 Homo sapiens 408 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662334 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662334&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407826 496710792 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120148 C[C@](C#C)(c1nc(NC(=O)NCCO)sc1Cl)c1ccc(Cl)cc1 |r| InChI=1S/C16H15Cl2N3O2S/c1-3-16(2,10-4-6-11(17)7-5-10)12-13(18)24-15(20-12)21-14(23)19-8-9-22/h1,4-7,22H,8-9H2,2H3,(H2,19,20,21,23) XTYLMGDADIAJEG-UHFFFAOYSA-N 662335 (R)-1-(5-chloro-4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A248::US20240226094, Compound A248::US20250241908, Compound A248::US20250381196, Compound A248 Alpha-protein kinase 1 Homo sapiens 1294 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662335 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662335&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407591 496710793 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120149 CC(C)(O)CCNC(=O)Nc1nc(C(C)(C)c2ccc(Cl)cc2)cs1 InChI=1S/C18H24ClN3O2S/c1-17(2,24)9-10-20-15(23)22-16-21-14(11-25-16)18(3,4)12-5-7-13(19)8-6-12/h5-8,11,24H,9-10H2,1-4H3,(H2,20,21,22,23) JSPQXWVWBPBOND-UHFFFAOYSA-N 75936 (S)-1-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 3-(3-hydroxy-3- methylbutyl)urea::US20250381196, Compound A249 Alpha-protein kinase 1 Homo sapiens 128 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75936 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75936&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 46846321 252653129 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120150 CC(C)(O)CCNC(=O)Nc1nc(cs1)[C@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C19H22ClN3O2S/c1-5-19(4,13-6-8-14(20)9-7-13)15-12-26-17(22-15)23-16(24)21-11-10-18(2,3)25/h1,6-9,12,25H,10-11H2,2-4H3,(H2,21,22,23,24) GGMASPYPWGCACZ-UHFFFAOYSA-N 662337 (R)-1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(3- hydroxy-3- methylbutyl)urea::US20240109853, Compound A250::US20240226094, Compound A250::US20250241908, Compound A250::US20250381196, Compound A250 Alpha-protein kinase 1 Homo sapiens 417 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662337&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407533 496710795 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120151 C[C@](C#C)(c1csc(NC(N)=O)n1)c1ccc(Cl)cc1 |r| InChI=1S/C14H12ClN3OS/c1-3-14(2,9-4-6-10(15)7-5-9)11-8-20-13(17-11)18-12(16)19/h1,4-8H,2H3,(H3,16,17,18,19) QNRVIEZGHCAXLQ-UHFFFAOYSA-N 662338 (R)-1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A251::US20240226094, Compound A251::US20250241908, Compound A251::US20250381196, Compound A251 Alpha-protein kinase 1 Homo sapiens 81.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662338&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407851 496710796 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120152 C[C@@](C#C)(c1csc(NC(N)=O)n1)c1ccc(Cl)cc1 |r| InChI=1S/C14H12ClN3OS/c1-3-14(2,9-4-6-10(15)7-5-9)11-8-20-13(17-11)18-12(16)19/h1,4-8H,2H3,(H3,16,17,18,19) QNRVIEZGHCAXLQ-UHFFFAOYSA-N 662339 (S)-1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)urea::US20240109853, Compound A252::US20240226094, Compound A252::US20250241908, Compound A252::US20250381196, Compound A252 Alpha-protein kinase 1 Homo sapiens 30.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662339 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662339&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407752 496710797 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120153 C#CC(C)(c1ccc(Cl)cc1)c2csc(NC(=O)N(CCO)CCO)n2 InChI=1S/C18H20ClN3O3S/c1-3-18(2,13-4-6-14(19)7-5-13)15-12-26-16(20-15)21-17(25)22(8-10-23)9-11-24/h1,4-7,12,23-24H,8-11H2,2H3,(H,20,21,25) FBJZLSGLSKTRIR-UHFFFAOYSA-N 662354 3-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-1,1- bis(2-hydroxyethyl)urea::US20240109853, Compound A267::US20250241908, Compound A267::US20250381196, Compound A267 Alpha-protein kinase 1 Homo sapiens 172 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662354&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120154 CN(CCO)C(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Cl)cc1 InChI=1S/C17H18ClN3O2S/c1-4-17(2,12-5-7-13(18)8-6-12)14-11-24-15(19-14)20-16(23)21(3)9-10-22/h1,5-8,11,22H,9-10H2,2-3H3,(H,19,20,23) HQPWGIPOGIXKHS-UHFFFAOYSA-N 662341 3-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-1-(2- hydroxyethyl)-1- methylurea::US20240109853, Compound A266::US20240109853, Compound A254::US20240226094, Compound A266::US20250241908, Compound A266::US20250381196, Compound A266 Alpha-protein kinase 1 Homo sapiens 548 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662341 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662341&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407824 496710799 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120155 COc1ccc(cc1)[C@@](C)(C#C)c1csc(NC(=O)N2CC(CO)C2)n1 |r| InChI=1S/C19H21N3O3S/c1-4-19(2,14-5-7-15(25-3)8-6-14)16-12-26-17(20-16)21-18(24)22-9-13(10-22)11-23/h1,5-8,12-13,23H,9-11H2,2-3H3,(H,20,21,24) PIOYJTYCBNCZAR-UHFFFAOYSA-N 662342 (R)-3-(hydroxymethyl)- N-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)azetidine-1- carboxamide::US20240109853, Compound A255::US20240226094, Compound A255::US20250241908, Compound A255::US20250381196, Compound A255 Alpha-protein kinase 1 Homo sapiens 109 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662342 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662342&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407447 496710800 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120156 COc1ccc(cc1)[C@](C)(C#C)c1csc(NC(=O)N2CC(CO)C2)n1 |r| InChI=1S/C19H21N3O3S/c1-4-19(2,14-5-7-15(25-3)8-6-14)16-12-26-17(20-16)21-18(24)22-9-13(10-22)11-23/h1,5-8,12-13,23H,9-11H2,2-3H3,(H,20,21,24) PIOYJTYCBNCZAR-UHFFFAOYSA-N 662343 (S)-3-(hydroxymethyl)- N-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)azetidine-1- carboxamide::US20240109853, Compound A256::US20240226094, Compound A256::US20250241908, Compound A256::US20250381196, Compound A256 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662343 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662343&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407858 496710801 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120157 C[C@](C#C)(c1csc(NC(=O)N2CC(CO)C2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C18H18ClN3O2S/c1-3-18(2,13-4-6-14(19)7-5-13)15-11-25-16(20-15)21-17(24)22-8-12(9-22)10-23/h1,4-7,11-12,23H,8-10H2,2H3,(H,20,21,24) MQAZWMBCKPVOID-UHFFFAOYSA-N 662344 (R)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (hydroxymethyl)azetidine- 1-carboxamide::US20240109853, Compound A257::US20240226094, Compound A257::US20250241908, Compound A257::US20250381196, Compound A257 Alpha-protein kinase 1 Homo sapiens 246 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662344 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662344&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407756 496710802 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120158 C[C@@](C#C)(c1csc(NC(=O)N2CC(CO)C2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C18H18ClN3O2S/c1-3-18(2,13-4-6-14(19)7-5-13)15-11-25-16(20-15)21-17(24)22-8-12(9-22)10-23/h1,4-7,11-12,23H,8-10H2,2H3,(H,20,21,24) MQAZWMBCKPVOID-UHFFFAOYSA-N 662345 (S)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (hydroxymethyl)azetidine- 1-carboxamide::US20240109853, Compound A258::US20240226094, Compound A258::US20250241908, Compound A258::US20250381196, Compound A258 Alpha-protein kinase 1 Homo sapiens 57.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662345 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662345&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407755 496710803 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120159 CC(C#C)(c1csc(NC(=O)N2CC(CN3CCNCC3)C2)n1)c1ccc(Cl)cc1 InChI=1S/C22H26ClN5OS/c1-3-22(2,17-4-6-18(23)7-5-17)19-15-30-20(25-19)26-21(29)28-13-16(14-28)12-27-10-8-24-9-11-27/h1,4-7,15-16,24H,8-14H2,2H3,(H,25,26,29) ZJVYFTYLEAYANA-UHFFFAOYSA-N 662346 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (piperazin-1- ylmethyl)azetidine-1- carboxamide::US20240109853, Compound A259::US20240226094, Compound A259::US20250241908, Compound A259::US20250381196, Compound A259 Alpha-protein kinase 1 Homo sapiens 48.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662346 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662346&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407434 496710804 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120160 C[C@@](C#C)(c1csc(NC(=O)N2CCc3cc(ccc3C2)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C27H28ClN5OS/c1-3-27(2,21-5-7-22(28)8-6-21)24-18-35-25(30-24)31-26(34)33-13-10-19-16-23(9-4-20(19)17-33)32-14-11-29-12-15-32/h1,4-9,16,18,29H,10-15,17H2,2H3,(H,30,31,34) MJXDVZNJCSACDC-UHFFFAOYSA-N 662347 (S)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-6- (piperazin-1-yl)-3,4- dihydroisoquinoline- 2(1H)-carboxamide::US20240109853, Compound A281::US20240109853, Compound A260::US20240226094, Compound A260::US20250381196, Compound A281 Alpha-protein kinase 1 Homo sapiens 74.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662347&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407739 496710805 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120161 CC(C#C)(c1csc(NC(=O)N2CC(C2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C21H24ClN5OS/c1-3-21(2,15-4-6-16(22)7-5-15)18-14-29-19(24-18)25-20(28)27-12-17(13-27)26-10-8-23-9-11-26/h1,4-7,14,17,23H,8-13H2,2H3,(H,24,25,28) YRZRJYJTGQOKCA-UHFFFAOYSA-N 662348 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (piperazin-1- yl)azetidine-1- carboxamide::US20240109853, Compound A261::US20240226094, Compound A261::US20250241908, Compound A261::US20250381196, Compound A261 Alpha-protein kinase 1 Homo sapiens 83.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662348 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662348&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407661 496710806 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120162 CC(C#C)(c1csc(NC(=O)NCc2ccc(N3CCNCC3)c(F)c2)n1)c1ccc(Cl)cc1 InChI=1S/C25H25ClFN5OS/c1-3-25(2,18-5-7-19(26)8-6-18)22-16-34-24(30-22)31-23(33)29-15-17-4-9-21(20(27)14-17)32-12-10-28-11-13-32/h1,4-9,14,16,28H,10-13,15H2,2H3,(H2,29,30,31,33) PPQHVXQGFJLDRG-UHFFFAOYSA-N 662349 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(3- fluoro-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound A262::US20240226094, Compound A262::US20250241908, Compound A262::US20250381196, Compound A262 Alpha-protein kinase 1 Homo sapiens 13.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662349 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662349&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407564 496710807 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120163 CC(C#C)(c1csc(NC(=O)N2CC(CN3CCC(N)CC3)C2)n1)c1ccc(Cl)cc1 InChI=1S/C23H28ClN5OS/c1-3-23(2,17-4-6-18(24)7-5-17)20-15-31-21(26-20)27-22(30)29-13-16(14-29)12-28-10-8-19(25)9-11-28/h1,4-7,15-16,19H,8-14,25H2,2H3,(H,26,27,30) BPFUGXSHPOBFLC-UHFFFAOYSA-N 662350 3-((4-aminopiperidin-1- yl)methyl)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)azetidine-1- carboxamide::US20240109853, Compound A263::US20240226094, Compound A263::US20250241908, Compound A263::US20250381196, Compound A263 Alpha-protein kinase 1 Homo sapiens 39.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662350 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662350&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407488 496710808 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120164 CC(C#C)(c1csc(NC(=O)N2CCC(CO)CC2)n1)c1ccc(Cl)cc1 InChI=1S/C20H22ClN3O2S/c1-3-20(2,15-4-6-16(21)7-5-15)17-13-27-18(22-17)23-19(26)24-10-8-14(12-25)9-11-24/h1,4-7,13-14,25H,8-12H2,2H3,(H,22,23,26) HWPBVIUUEGUTSR-UHFFFAOYSA-N 662351 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-4- (hydroxymethyl)piperidine- 1-carboxamide::US20240109853, Compound A264::US20240226094, Compound A264::US20250241908, Compound A264::US20250381196, Compound A264 Alpha-protein kinase 1 Homo sapiens 1374 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662351 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662351&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407864 496710809 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120165 CC(C#C)(c1csc(NC(=O)N2CCC(N)CC2)n1)c1ccc(Cl)cc1 InChI=1S/C19H21ClN4OS/c1-3-19(2,13-4-6-14(20)7-5-13)16-12-26-17(22-16)23-18(25)24-10-8-15(21)9-11-24/h1,4-7,12,15H,8-11,21H2,2H3,(H,22,23,25) SYSKETOZAYHALM-UHFFFAOYSA-N 662352 4-amino-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)piperidine-1- carboxamide::US20240109853, Compound A265::US20240226094, Compound A265::US20250241908, Compound A265::US20250381196, Compound A265 Alpha-protein kinase 1 Homo sapiens 4974 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662352 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662352&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407376 496710810 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120166 CN(CCO)C(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Cl)cc1 InChI=1S/C17H18ClN3O2S/c1-4-17(2,12-5-7-13(18)8-6-12)14-11-24-15(19-14)20-16(23)21(3)9-10-22/h1,5-8,11,22H,9-10H2,2-3H3,(H,19,20,23) HQPWGIPOGIXKHS-UHFFFAOYSA-N 662341 3-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-1-(2- hydroxyethyl)-1- methylurea::US20240109853, Compound A266::US20240109853, Compound A254::US20240226094, Compound A266::US20250241908, Compound A266::US20250381196, Compound A266 Alpha-protein kinase 1 Homo sapiens 546 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662341 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662341&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407824 496710799 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120167 C#CC(C)(c1ccc(Cl)cc1)c2csc(NC(=O)N(CCO)CCO)n2 InChI=1S/C18H20ClN3O3S/c1-3-18(2,13-4-6-14(19)7-5-13)15-12-26-16(20-15)21-17(25)22(8-10-23)9-11-24/h1,4-7,12,23-24H,8-11H2,2H3,(H,20,21,25) FBJZLSGLSKTRIR-UHFFFAOYSA-N 662354 3-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-1,1- bis(2-hydroxyethyl)urea::US20240109853, Compound A267::US20250241908, Compound A267::US20250381196, Compound A267 Alpha-protein kinase 1 Homo sapiens 171 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662354&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120168 CC(C)(O)CNC(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Cl)cc1 InChI=1S/C18H20ClN3O2S/c1-5-18(4,12-6-8-13(19)9-7-12)14-10-25-16(21-14)22-15(23)20-11-17(2,3)24/h1,6-10,24H,11H2,2-4H3,(H2,20,21,22,23) UPXBSRQVYSSCDI-UHFFFAOYSA-N 662355 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxy-2- methylpropyl)urea::US20240109853, Compound A268::US20240226094, Compound A268::US20250241908, Compound A268::US20250381196, Compound A268 Alpha-protein kinase 1 Homo sapiens 218 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662355 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662355&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407440 496710811 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120169 CC(C#C)(c1csc(NC(=O)N2CCC(O)C2)n1)c1ccc(Cl)cc1 InChI=1S/C18H18ClN3O2S/c1-3-18(2,12-4-6-13(19)7-5-12)15-11-25-16(20-15)21-17(24)22-9-8-14(23)10-22/h1,4-7,11,14,23H,8-10H2,2H3,(H,20,21,24) PRPYUMPBVVHFOP-UHFFFAOYSA-N 662356 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- hydroxypyrrolidine-1- carboxamide::US20240109853, Compound A269::US20250241908, Compound A269::US20250381196, Compound A269 Alpha-protein kinase 1 Homo sapiens 881 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662356 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662356&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407717 496710812 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120170 CC(C#C)(c1csc(NC(=O)N2CCC(CO)C2)n1)c1ccc(Cl)cc1 InChI=1S/C19H20ClN3O2S/c1-3-19(2,14-4-6-15(20)7-5-14)16-12-26-17(21-16)22-18(25)23-9-8-13(10-23)11-24/h1,4-7,12-13,24H,8-11H2,2H3,(H,21,22,25) AQYDJQOSCOLCDO-UHFFFAOYSA-N 662357 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (hydroxymethyl)pyrroli- dine-1-carboxamide::US20240109853, Compound A270::US20240226094, Compound A270::US20250241908, Compound A270::US20250381196, Compound A270 Alpha-protein kinase 1 Homo sapiens 904 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662357 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662357&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407678 496710813 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120171 CC(C#C)(c1csc(NC(=O)NO)n1)c1ccc(Cl)cc1 InChI=1S/C14H12ClN3O2S/c1-3-14(2,9-4-6-10(15)7-5-9)11-8-21-13(16-11)17-12(19)18-20/h1,4-8,20H,2H3,(H2,16,17,18,19) VZJNLXAUQBXGFO-UHFFFAOYSA-N 662358 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- hydroxyurea::US20240109853, Compound A271::US20240226094, Compound A271::US20250241908, Compound A271::US20250381196, Compound A271 Alpha-protein kinase 1 Homo sapiens 493 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662358 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662358&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407794 496710814 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120172 CC(C#C)(c1csc(NC(=O)NCCc2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C26H28ClN5OS/c1-3-26(2,20-6-8-21(27)9-7-20)23-18-34-25(30-23)31-24(33)29-13-12-19-4-10-22(11-5-19)32-16-14-28-15-17-32/h1,4-11,18,28H,12-17H2,2H3,(H2,29,30,31,33) KDECPHCTBJSWGI-UHFFFAOYSA-N 662359 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)phenethyl)urea::US20240109853, Compound A272::US20240226094, Compound A272::US20250241908, Compound A272::US20250381196, Compound A272 Alpha-protein kinase 1 Homo sapiens 135 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662359 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662359&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407498 496710815 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120173 CC(C#C)(c1csc(NC(=O)Cc2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C25H25ClN4OS/c1-3-25(2,19-6-8-20(26)9-7-19)22-17-32-24(28-22)29-23(31)16-18-4-10-21(11-5-18)30-14-12-27-13-15-30/h1,4-11,17,27H,12-16H2,2H3,(H,28,29,31) BLVJXTWFPMAICD-UHFFFAOYSA-N 662360 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-2-(4- (piperazin-1- yl)phenyl)acetamide::US20240109853, Compound A273::US20240226094, Compound A273::US20250241908, Compound A273::US20250381196, Compound A273 Alpha-protein kinase 1 Homo sapiens 60.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662360 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662360&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407782 496710816 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120174 CC(NC(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Cl)cc1)C1CCNCC1 InChI=1S/C21H25ClN4OS/c1-4-21(3,16-5-7-17(22)8-6-16)18-13-28-20(25-18)26-19(27)24-14(2)15-9-11-23-12-10-15/h1,5-8,13-15,23H,9-12H2,2-3H3,(H2,24,25,26,27) NQDBBXYQEICOHO-UHFFFAOYSA-N 662361 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(1- (piperidin-4- yl)ethyl)urea::US20240109853, Compound A274::US20240226094, Compound A274::US20250241908, Compound A274::US20250381196, Compound A274 Alpha-protein kinase 1 Homo sapiens 467 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662361 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662361&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407571 496710817 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120175 CC(C#C)(c1csc(NC(=O)N2CC(N)C2)n1)c1ccc(Cl)cc1 InChI=1S/C17H17ClN4OS/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-24-15(20-14)21-16(23)22-8-13(19)9-22/h1,4-7,10,13H,8-9,19H2,2H3,(H,20,21,23) HFAWEIXZDHVLNX-UHFFFAOYSA-N 662362 3-amino-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)azetidine-1- carboxamide::US20240109853, Compound A275::US20240226094, Compound A275::US20250241908, Compound A275::US20250381196, Compound A275 Alpha-protein kinase 1 Homo sapiens 503 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662362&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407705 496710818 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120176 CC(C#C)(c1csc(NC(N)=N)n1)c1ccc(Cl)cc1 InChI=1S/C14H13ClN4S/c1-3-14(2,9-4-6-10(15)7-5-9)11-8-20-13(18-11)19-12(16)17/h1,4-8H,2H3,(H4,16,17,18,19) MMQXIMSHUHHVQT-UHFFFAOYSA-N 662363 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)guanidine::US20240109853, Compound A276::US20240226094, Compound A276::US20250241908, Compound A276::US20250381196, Compound A276 Alpha-protein kinase 1 Homo sapiens 475 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662363&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407401 496710819 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120177 CC(C#C)(c1csc(NC(=O)NCCc2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C26H28ClN5OS/c1-3-26(2,20-6-8-21(27)9-7-20)23-18-34-25(30-23)31-24(33)29-13-12-19-4-10-22(11-5-19)32-16-14-28-15-17-32/h1,4-11,18,28H,12-17H2,2H3,(H2,29,30,31,33) KDECPHCTBJSWGI-UHFFFAOYSA-N 662359 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)phenethyl)urea::US20240109853, Compound A272::US20240226094, Compound A272::US20250241908, Compound A272::US20250381196, Compound A272 Alpha-protein kinase 1 Homo sapiens 666 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662359 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662359&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407498 496710815 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120178 CC(C#C)(c1csc(NC(=O)Cc2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C25H25ClN4OS/c1-3-25(2,19-6-8-20(26)9-7-19)22-17-32-24(28-22)29-23(31)16-18-4-10-21(11-5-18)30-14-12-27-13-15-30/h1,4-11,17,27H,12-16H2,2H3,(H,28,29,31) BLVJXTWFPMAICD-UHFFFAOYSA-N 662360 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-2-(4- (piperazin-1- yl)phenyl)acetamide::US20240109853, Compound A273::US20240226094, Compound A273::US20250241908, Compound A273::US20250381196, Compound A273 Alpha-protein kinase 1 Homo sapiens 237 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662360 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662360&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407782 496710816 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120179 CC(NC(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Cl)cc1)C1CCNCC1 InChI=1S/C21H25ClN4OS/c1-4-21(3,16-5-7-17(22)8-6-16)18-13-28-20(25-18)26-19(27)24-14(2)15-9-11-23-12-10-15/h1,5-8,13-15,23H,9-12H2,2-3H3,(H2,24,25,26,27) NQDBBXYQEICOHO-UHFFFAOYSA-N 662361 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(1- (piperidin-4- yl)ethyl)urea::US20240109853, Compound A274::US20240226094, Compound A274::US20250241908, Compound A274::US20250381196, Compound A274 Alpha-protein kinase 1 Homo sapiens 327 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662361 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662361&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407571 496710817 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120180 CC(C#C)(c1csc(NC(=O)N2CC(N)C2)n1)c1ccc(Cl)cc1 InChI=1S/C17H17ClN4OS/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-24-15(20-14)21-16(23)22-8-13(19)9-22/h1,4-7,10,13H,8-9,19H2,2H3,(H,20,21,23) HFAWEIXZDHVLNX-UHFFFAOYSA-N 662362 3-amino-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)azetidine-1- carboxamide::US20240109853, Compound A275::US20240226094, Compound A275::US20250241908, Compound A275::US20250381196, Compound A275 Alpha-protein kinase 1 Homo sapiens 246 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662362 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662362&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407705 496710818 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120181 CC(C#C)(c1csc(NC(N)=N)n1)c1ccc(Cl)cc1 InChI=1S/C14H13ClN4S/c1-3-14(2,9-4-6-10(15)7-5-9)11-8-20-13(18-11)19-12(16)17/h1,4-8H,2H3,(H4,16,17,18,19) MMQXIMSHUHHVQT-UHFFFAOYSA-N 662363 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)guanidine::US20240109853, Compound A276::US20240226094, Compound A276::US20250241908, Compound A276::US20250381196, Compound A276 Alpha-protein kinase 1 Homo sapiens 345 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662363&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407401 496710819 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120182 C[C@](C#C)(c1csc(NC(=O)NCC(O)CO)n1)c1ccc(Br)cc1 |r| InChI=1S/C17H18BrN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-8-13(23)9-22/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) NMJJFJMQVZYOLO-UHFFFAOYSA-N 662364 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (2,3- dihydroxypropyl)urea::US20240109853, Compound A277::US20240226094, Compound A282::US20250241908, Compound A277::US20250381196, Compound A277 Alpha-protein kinase 1 Homo sapiens 2667 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662364&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407798 496710820 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120183 C[C@@](C#C)(c1csc(NC(=O)NCC(O)CO)n1)c1ccc(Br)cc1 |r| InChI=1S/C17H18BrN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-8-13(23)9-22/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) NMJJFJMQVZYOLO-UHFFFAOYSA-N 662365 1-(4-(2-(4- bromophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (2,3- dihydroxypropyl)urea::US20240109853, Compound A278::US20240226094, Compound A283::US20250241908, Compound A278::US20250381196, Compound A278 Alpha-protein kinase 1 Homo sapiens 624 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662365 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662365&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407581 496710821 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120184 CC(C#C)(c1nc(NC(=O)NCCO)sc1F)c1ccc(Cl)cc1 InChI=1S/C16H15ClFN3O2S/c1-3-16(2,10-4-6-11(17)7-5-10)12-13(18)24-15(20-12)21-14(23)19-8-9-22/h1,4-7,22H,8-9H2,2H3,(H2,19,20,21,23) PRHRRPYKGGCEKQ-UHFFFAOYSA-N 662366 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)-5-fluorothiazol-2- yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A290::US20240109853, Compound A279::US20240226094, Compound A295::US20250241908, Compound A290::US20250381196, Compound A290 Alpha-protein kinase 1 Homo sapiens 222 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662366&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407713 496710822 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120185 C[C@](C#C)(c1csc(NC(=O)N2CCc3cc(ccc3C2)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C27H28ClN5OS/c1-3-27(2,21-5-7-22(28)8-6-21)24-18-35-25(30-24)31-26(34)33-13-10-19-16-23(9-4-20(19)17-33)32-14-11-29-12-15-32/h1,4-9,16,18,29H,10-15,17H2,2H3,(H,30,31,34) MJXDVZNJCSACDC-UHFFFAOYSA-N 662367 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-6- (piperazin-1-yl)-3,4- dihydroisoquinoline- 2(1H)-carboxamide::US20240109853, Compound A280::US20240226094, Compound A285::US20250241908, Compound A280::US20250381196, Compound A280 Alpha-protein kinase 1 Homo sapiens 21.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662367&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407850 496710823 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120186 C[C@@](C#C)(c1csc(NC(=O)N2CCc3cc(ccc3C2)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C27H28ClN5OS/c1-3-27(2,21-5-7-22(28)8-6-21)24-18-35-25(30-24)31-26(34)33-13-10-19-16-23(9-4-20(19)17-33)32-14-11-29-12-15-32/h1,4-9,16,18,29H,10-15,17H2,2H3,(H,30,31,34) MJXDVZNJCSACDC-UHFFFAOYSA-N 662347 (S)-N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-6- (piperazin-1-yl)-3,4- dihydroisoquinoline- 2(1H)-carboxamide::US20240109853, Compound A281::US20240109853, Compound A260::US20240226094, Compound A260::US20250381196, Compound A281 Alpha-protein kinase 1 Homo sapiens 38.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662347&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407739 496710805 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120187 C[C@](C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(F)cc1 |r| InChI=1S/C16H16FN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22) PDOYDUUIGIZLIE-UHFFFAOYSA-N 662369 1-(4-(2-(4- fluorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A282::US20240226094, Compound A287::US20250241908, Compound A282::US20250381196, Compound A282 Alpha-protein kinase 1 Homo sapiens 2153 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662369&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407870 496710824 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120188 C[C@@](C#C)(c1csc(NC(=O)NCCO)n1)c1ccc(F)cc1 |r| InChI=1S/C16H16FN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22) PDOYDUUIGIZLIE-UHFFFAOYSA-N 684872 1-(4-(2-(4- fluorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 3-(2- hydroxyethyl)urea::US20240226094, Compound A288::US20250241908, Compound A283::US20250381196, Compound A283 Alpha-protein kinase 1 Homo sapiens 550 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=684872 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=684872&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171753813 503274234 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120189 C[C@](C#C)(c1csc(NC(=O)NCCS(N)(=O)=O)n1)c1ccc(F)cc1 |r| InChI=1S/C16H17FN4O3S2/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-25-15(20-13)21-14(22)19-8-9-26(18,23)24/h1,4-7,10H,8-9H2,2H3,(H2,18,23,24)(H2,19,20,21,22) QLPRVRAQDJYXSP-UHFFFAOYSA-N 662371 2-(3-(4-(2-(4- fluorophenyl)but-3-yn- 2-yl)thiazol-2- yl)ureido)ethanesulfona- mide::US20240109853, Compound A284::US20240226094, Compound A289::US20250241908, Compound A284::US20250381196, Compound A284 Alpha-protein kinase 1 Homo sapiens 666 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662371 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662371&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407750 496710826 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120190 C[C@@](C#C)(c1csc(NC(=O)NCCS(N)(=O)=O)n1)c1ccc(F)cc1 |r| InChI=1S/C16H17FN4O3S2/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-25-15(20-13)21-14(22)19-8-9-26(18,23)24/h1,4-7,10H,8-9H2,2H3,(H2,18,23,24)(H2,19,20,21,22) QLPRVRAQDJYXSP-UHFFFAOYSA-N 662372 2-(3-(4-(2-(4- fluorophenyl)but-3-yn- 2-yl)thiazol-2- yl)ureido)ethanesulfona- mide::US20240109853, Compound A285::US20240226094, Compound A290::US20250241908, Compound A285::US20250381196, Compound A285 Alpha-protein kinase 1 Homo sapiens 350 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662372 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662372&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407379 496710827 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120191 C[C@](C#C)(c1csc(NC(=O)NCC2(O)CNC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C18H19ClN4O2S/c1-3-17(2,12-4-6-13(19)7-5-12)14-8-26-16(22-14)23-15(24)21-11-18(25)9-20-10-18/h1,4-8,20,25H,9-11H2,2H3,(H2,21,22,23,24) CFMHAZZFZNORGH-UHFFFAOYSA-N 662373 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-((3- hydroxyazetidin-3- yl)methyl)urea::US20240109853, Compound A286::US20240226094, Compound A291::US20250241908, Compound A286::US20250381196, Compound A286 Alpha-protein kinase 1 Homo sapiens 495 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662373&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171665627 496710828 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120192 C[C@@](C#C)(c1csc(NC(=O)NCC2(O)CNC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C18H19ClN4O2S/c1-3-17(2,12-4-6-13(19)7-5-12)14-8-26-16(22-14)23-15(24)21-11-18(25)9-20-10-18/h1,4-8,20,25H,9-11H2,2H3,(H2,21,22,23,24) CFMHAZZFZNORGH-UHFFFAOYSA-N 662374 1-(4-(2-(4- chlorophenyl)but-3-yn-2- yl)thiazol-2-yl)-3-((3- hydroxyazetidin-3- yl)methyl)urea::US20240109853, Compound A287::US20240226094, Compound A292::US20250241908, Compound A287::US20250381196, Compound A287 Alpha-protein kinase 1 Homo sapiens 130 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662374&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171665628 496710829 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120193 C[C@](C#C)(c1csc(NC(=O)NCCS(N)(=O)=O)n1)c1ccc(Cl)cc1 |r| InChI=1S/C16H17ClN4O3S2/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-25-15(20-13)21-14(22)19-8-9-26(18,23)24/h1,4-7,10H,8-9H2,2H3,(H2,18,23,24)(H2,19,20,21,22) IWQSVWOJUIJSGQ-UHFFFAOYSA-N 662375 2-(3-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)ureido)ethanesulfona- mide::US20240109853, Compound A288::US20240226094, Compound A293::US20250241908, Compound A288::US20250381196, Compound A288 Alpha-protein kinase 1 Homo sapiens 270 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662375&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407463 496710830 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120194 C[C@@](C#C)(c1csc(NC(=O)NCCS(N)(=O)=O)n1)c1ccc(Cl)cc1 |r| InChI=1S/C16H17ClN4O3S2/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-25-15(20-13)21-14(22)19-8-9-26(18,23)24/h1,4-7,10H,8-9H2,2H3,(H2,18,23,24)(H2,19,20,21,22) IWQSVWOJUIJSGQ-UHFFFAOYSA-N 662376 2-(3-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)ureido)ethanesulfona- mide::US20240109853, Compound A289::US20240226094, Compound A294::US20250241908, Compound A289::US20250381196, Compound A289 Alpha-protein kinase 1 Homo sapiens 54.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662376&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407833 496710831 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120195 CC(C#C)(c1nc(NC(=O)NCCO)sc1F)c1ccc(Cl)cc1 InChI=1S/C16H15ClFN3O2S/c1-3-16(2,10-4-6-11(17)7-5-10)12-13(18)24-15(20-12)21-14(23)19-8-9-22/h1,4-7,22H,8-9H2,2H3,(H2,19,20,21,23) PRHRRPYKGGCEKQ-UHFFFAOYSA-N 662366 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)-5-fluorothiazol-2- yl)-3-(2- hydroxyethyl)urea::US20240109853, Compound A290::US20240109853, Compound A279::US20240226094, Compound A295::US20250241908, Compound A290::US20250381196, Compound A290 Alpha-protein kinase 1 Homo sapiens 222 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662366&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407713 496710822 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120196 C[C@](C#C)(c1csc(NC(=O)N2CC(CN3CCNCC3)C2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C22H26ClN5OS/c1-3-22(2,17-4-6-18(23)7-5-17)19-15-30-20(25-19)26-21(29)28-13-16(14-28)12-27-10-8-24-9-11-27/h1,4-7,15-16,24H,8-14H2,2H3,(H,25,26,29) ZJVYFTYLEAYANA-UHFFFAOYSA-N 662378 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (piperazin-1- ylmethyl)azetidine-1- carboxamide::US20240109853, Compound A291::US20240226094, Compound A296::US20250241908, Compound A291::US20250381196, Compound A291 Alpha-protein kinase 1 Homo sapiens 109 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662378&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407764 496710832 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120197 C[C@@](C#C)(c1csc(NC(=O)N2CC(CN3CCNCC3)C2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C22H26ClN5OS/c1-3-22(2,17-4-6-18(23)7-5-17)19-15-30-20(25-19)26-21(29)28-13-16(14-28)12-27-10-8-24-9-11-27/h1,4-7,15-16,24H,8-14H2,2H3,(H,25,26,29) ZJVYFTYLEAYANA-UHFFFAOYSA-N 662379 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (piperazin-1- ylmethyl)azetidine-1- carboxamide::US20240109853, Compound A292::US20240226094, Compound A297::US20250241908, Compound A292::US20250381196, Compound A292 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662379&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407608 496710833 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120198 CC(C)(CO)NC(=O)Nc1nc(cs1)[C@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C18H20ClN3O2S/c1-5-18(4,12-6-8-13(19)9-7-12)14-10-25-16(20-14)21-15(24)22-17(2,3)11-23/h1,6-10,23H,11H2,2-4H3,(H2,20,21,22,24) IZJOCNUWIULENZ-UHFFFAOYSA-N 662380 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(1- hydroxy-2- methylpropan-2-yl)urea::US20240109853, Compound A293::US20240226094, Compound A298::US20250241908, Compound A293::US20250381196, Compound A293 Alpha-protein kinase 1 Homo sapiens 9361 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662380&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407393 496710834 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120199 CC(C)(CO)NC(=O)Nc1nc(cs1)[C@@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C18H20ClN3O2S/c1-5-18(4,12-6-8-13(19)9-7-12)14-10-25-16(20-14)21-15(24)22-17(2,3)11-23/h1,6-10,23H,11H2,2-4H3,(H2,20,21,22,24) IZJOCNUWIULENZ-UHFFFAOYSA-N 662381 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(1- hydroxy-2- methylpropan-2-yl)urea::US20240109853, Compound A294::US20240226094, Compound A299::US20250241908, Compound A294::US20250381196, Compound A294 Alpha-protein kinase 1 Homo sapiens 285 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662381&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407842 496710835 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120200 C[C@@](C#C)(c1csc(NC(=O)NC2(CO)CC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C18H18ClN3O2S/c1-3-17(2,12-4-6-13(19)7-5-12)14-10-25-16(20-14)21-15(24)22-18(11-23)8-9-18/h1,4-7,10,23H,8-9,11H2,2H3,(H2,20,21,22,24) FWIUUCYWFKEYEK-UHFFFAOYSA-N 662382 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(1- (hydroxymethyl)cyclopro- pyl)urea::US20240109853, Compound A295::US20240226094, Compound A300::US20250241908, Compound A295::US20250381196, Compound A295 Alpha-protein kinase 1 Homo sapiens 522 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662382&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407443 496710836 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120201 C[C@](C#C)(c1csc(NC(=O)NC2(CO)CC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C18H18ClN3O2S/c1-3-17(2,12-4-6-13(19)7-5-12)14-10-25-16(20-14)21-15(24)22-18(11-23)8-9-18/h1,4-7,10,23H,8-9,11H2,2H3,(H2,20,21,22,24) FWIUUCYWFKEYEK-UHFFFAOYSA-N 662383 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(1- hydroxymethyl)cyclopro- pyl)urea::US20240109853, Compound A296::US20240226094, Compound A301::US20250241908, Compound A296::US20250381196, Compound A296 Alpha-protein kinase 1 Homo sapiens 114 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662383&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407779 496710837 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120202 C[C@](C#C)(c1csc(NC(=O)NC(CO)CO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-13(8-22)9-23/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) FSNCZSWGQGQTFL-UHFFFAOYSA-N 662384 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (1,3-dihydroxypropan-2- yl)urea::US20240109853, Compound A297::US20240226094, Compound A302::US20250241908, Compound A297::US20250381196, Compound A297 Alpha-protein kinase 1 Homo sapiens 935 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662384&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407775 496710838 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120203 C[C@@](C#C)(c1csc(NC(=O)NC(CO)CO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-13(8-22)9-23/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) FSNCZSWGQGQTFL-UHFFFAOYSA-N 662385 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- (1,3-dihydroxypropan-2- yl)urea::US20240109853, Compound A298::US20240226094, Compound A303::US20250241908, Compound A298::US20250381196, Compound A298 Alpha-protein kinase 1 Homo sapiens 246 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662385&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407576 496710839 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120204 [2H]c1sc(NC(=O)NCCO)nc1[C@@](C)(C#C)c1ccc(Cl)cc1 InChI=1S/C16H16ClN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22)/i10D IQPXNEQCZAHNPG-MMIHMFRQSA-N 761318 1-(4-(2-(4-chlorophenyl)- but-3-yn-2-yl)thiazol-2- yl)-3-(2-hydroxyethyl)- urea::US20250241908, Compound A299::US20250381196, Compound A299 Alpha-protein kinase 1 Homo sapiens 58.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=761318 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=761318&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407569 520671585 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120205 [2H]c1sc(NC(=O)NCCO)nc1[C@](C)(C#C)c1ccc(Cl)cc1 InChI=1S/C16H16ClN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22)/i10D IQPXNEQCZAHNPG-MMIHMFRQSA-N 761319 1-(4-(2-(4-chlorophenyl)- but-3-yn-2-yl)thiazol-2- yl)-3-(2-hydroxyethyl)- urea::US20250241908, Compound A300::US20250381196, Compound A300 Alpha-protein kinase 1 Homo sapiens 341 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=761319 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=761319&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407768 520671586 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120206 C[C@](C#C)(c1csc(NC(=O)NC[C@@H](O)CO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-8-13(23)9-22/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) RIWKXPKOFLBNNF-UHFFFAOYSA-N 662388 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- ((R)-2,3- dihydroxypropyl)urea::US20240109853, Compound A301::US20240226094, Compound A306::US20250241908, Compound A301::US20250381196, Compound A301 Alpha-protein kinase 1 Homo sapiens 354 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662388&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407763 496710840 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120207 C[C@](C#C)(c1csc(NC(=O)NC[C@H](O)CO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-8-13(23)9-22/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) RIWKXPKOFLBNNF-UHFFFAOYSA-N 662389 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- ((S)-2,3- dihydroxypropyl)urea::US20240109853, Compound A302::US20240226094, Compound A307::US20250241908, Compound A302::US20250381196, Compound A302 Alpha-protein kinase 1 Homo sapiens 417 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662389&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407578 496710841 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120208 C[C@@](C#C)(c1csc(NC(=O)NC[C@@H](O)CO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-8-13(23)9-22/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) RIWKXPKOFLBNNF-UHFFFAOYSA-N 662390 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- ((R)-2,3- dihydroxypropyl)urea::US20240109853, Compound A303::US20240226094, Compound A308::US20250241908, Compound A303::US20250381196, Compound A303 Alpha-protein kinase 1 Homo sapiens 101 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662390&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407762 496710842 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120209 C[C@@](C#C)(c1csc(NC(=O)NC[C@H](O)CO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O3S/c1-3-17(2,11-4-6-12(18)7-5-11)14-10-25-16(20-14)21-15(24)19-8-13(23)9-22/h1,4-7,10,13,22-23H,8-9H2,2H3,(H2,19,20,21,24) RIWKXPKOFLBNNF-UHFFFAOYSA-N 662391 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3- ((S)-2,3- dihydroxypropyl)urea::US20240109853, Compound A304::US20240226094, Compound A309::US20250241908, Compound A304::US20250381196, Compound A304 Alpha-protein kinase 1 Homo sapiens 90.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662391&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407621 496710843 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120210 CC(C)(O)CNC(=O)Nc1nc(cs1)[C@](C)(C#C)c1ccc(Br)cc1 |r| InChI=1S/C18H20BrN3O2S/c1-5-18(4,12-6-8-13(19)9-7-12)14-10-25-16(21-14)22-15(23)20-11-17(2,3)24/h1,6-10,24H,11H2,2-4H3,(H2,20,21,22,23) AJADYJUMNQUBKP-UHFFFAOYSA-N 662392 1-[4-[1-(4- bromophenyl)-1-methyl- prop-2-ynyl]thiazol-2- yl]-3-(2-hydroxy-2- methyl-propyl)urea::US20240109853, Compound A305::US20240226094, Compound A310::US20250241908, Compound A305::US20250381196, Compound A305 Alpha-protein kinase 1 Homo sapiens 167 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662392&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407746 496710844 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120211 CC(C)(O)CNC(=O)Nc1nc(cs1)[C@@](C)(C#C)c1ccc(Br)cc1 |r| InChI=1S/C18H20BrN3O2S/c1-5-18(4,12-6-8-13(19)9-7-12)14-10-25-16(21-14)22-15(23)20-11-17(2,3)24/h1,6-10,24H,11H2,2-4H3,(H2,20,21,22,23) AJADYJUMNQUBKP-UHFFFAOYSA-N 662393 1-[4-[1-(4- bromophenyl)-1-methyl- prop-2-ynyl]thiazol-2- yl]-3-(2-hydroxy-2- methyl-propyl)urea::US20240109853, Compound A306::US20240226094, Compound A311::US20250241908, Compound A306::US20250381196, Compound A306 Alpha-protein kinase 1 Homo sapiens 56.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662393&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407754 496710845 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120212 CC(C#C)(c1csc(NC(=O)N2CCC(O)CC2)n1)c1ccc(Cl)cc1 InChI=1S/C19H20ClN3O2S/c1-3-19(2,13-4-6-14(20)7-5-13)16-12-26-17(21-16)22-18(25)23-10-8-15(24)9-11-23/h1,4-7,12,15,24H,8-11H2,2H3,(H,21,22,25) OOCIHNCMVIVIRV-UHFFFAOYSA-N 662394 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-4- hydroxypiperidine-1- carboxamide::US20240109853, Compound A307::US20240226094, Compound A312::US20250241908, Compound A307::US20250381196, Compound A307 Alpha-protein kinase 1 Homo sapiens 2058 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662394&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407419 496710846 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120213 CC(C#C)(c1csc(NC(=O)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C18H19ClN4OS/c1-3-18(2,13-4-6-14(19)7-5-13)15-12-25-16(21-15)22-17(24)23-10-8-20-9-11-23/h1,4-7,12,20H,8-11H2,2H3,(H,21,22,24) ZACYNSIMWBYGFR-UHFFFAOYSA-N 662395 N-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2- yl)piperazine-1- carboxamide::US20240109853, Compound A308::US20240226094, Compound A313::US20250241908, Compound A308::US20250381196, Compound A308 Alpha-protein kinase 1 Homo sapiens 1535 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662395 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662395&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407776 496710847 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120214 Cc1ccc(CN2CCC(C2)NC(=O)Nc2nc(cs2)C(C)(C#C)c2ccc(Cl)cc2)cc1 InChI=1S/C26H27ClN4OS/c1-4-26(3,20-9-11-21(27)12-10-20)23-17-33-25(29-23)30-24(32)28-22-13-14-31(16-22)15-19-7-5-18(2)6-8-19/h1,5-12,17,22H,13-16H2,2-3H3,(H2,28,29,30,32) USCQMAMPKQOMDO-UHFFFAOYSA-N 662396 1-(4-(2-(4- chlorophenyl)but-3-yn- 2-yl)thiazol-2-yl)-3-(1- (4- methylbenzyl)pyrrolidin- 3-yl)urea::US20240109853, Compound A309::US20240226094, Compound A314::US20250241908, Compound A309::US20250381196, Compound A309 Alpha-protein kinase 1 Homo sapiens 1414 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662396&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407796 496703669 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120215 COc1ccc(cc1)[C@@](C)(C#C)c1csc(NC(=O)NCCS(N)(=O)=O)n1 |r| InChI=1S/C17H20N4O4S2/c1-4-17(2,12-5-7-13(25-3)8-6-12)14-11-26-16(20-14)21-15(22)19-9-10-27(18,23)24/h1,5-8,11H,9-10H2,2-3H3,(H2,18,23,24)(H2,19,20,21,22) BMMAQCCMZIGYEC-UHFFFAOYSA-N 662397 2-(3-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)ureido)ethanesulfona- mide::US20240109853, Compound A310::US20240226094, Compound A315::US20250241908, Compound A310::US20250381196, Compound A310 Alpha-protein kinase 1 Homo sapiens 223 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662397&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407439 496703670 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120216 COc1ccc(cc1)[C@](C)(C#C)c1csc(NC(=O)NCCS(N)(=O)=O)n1 |r| InChI=1S/C17H20N4O4S2/c1-4-17(2,12-5-7-13(25-3)8-6-12)14-11-26-16(20-14)21-15(22)19-9-10-27(18,23)24/h1,5-8,11H,9-10H2,2-3H3,(H2,18,23,24)(H2,19,20,21,22) BMMAQCCMZIGYEC-UHFFFAOYSA-N 662398 2-(3-(4-(2-(4- methoxyphenyl)but-3- yn-2-yl)thiazol-2- yl)ureido)ethanesulfona- mide::US20240109853, Compound A311::US20240226094, Compound A316::US20250241908, Compound A311::US20250381196, Compound A311 Alpha-protein kinase 1 Homo sapiens 95.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662398 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662398&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407866 496703671 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120217 CC(CO)NC(=O)Nc1nc(cs1)[C@@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O2S/c1-4-17(3,12-5-7-13(18)8-6-12)14-10-24-16(20-14)21-15(23)19-11(2)9-22/h1,5-8,10-11,22H,9H2,2-3H3,(H2,19,20,21,23) YZORPNPHOCDTPW-UHFFFAOYSA-N 662399 US20240109853, Compound A312::US20240109853, Compound A313::1-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 3-(1-hydroxypropan- 2-yl)urea::US20240226094, Compound A318::US20250241908, Compound A313::US20250381196, Compound A313 Alpha-protein kinase 1 Homo sapiens 545 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662399 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662399&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407837 496703672 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120218 CC(CO)NC(=O)Nc1nc(cs1)[C@@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O2S/c1-4-17(3,12-5-7-13(18)8-6-12)14-10-24-16(20-14)21-15(23)19-11(2)9-22/h1,5-8,10-11,22H,9H2,2-3H3,(H2,19,20,21,23) YZORPNPHOCDTPW-UHFFFAOYSA-N 662399 US20240109853, Compound A312::US20240109853, Compound A313::1-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 3-(1-hydroxypropan- 2-yl)urea::US20240226094, Compound A318::US20250241908, Compound A313::US20250381196, Compound A313 Alpha-protein kinase 1 Homo sapiens 614 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662399 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662399&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407837 496703672 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120219 CC(CO)NC(=O)Nc1nc(cs1)[C@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O2S/c1-4-17(3,12-5-7-13(18)8-6-12)14-10-24-16(20-14)21-15(23)19-11(2)9-22/h1,5-8,10-11,22H,9H2,2-3H3,(H2,19,20,21,23) YZORPNPHOCDTPW-UHFFFAOYSA-N 662401 US20240109853, Compound A314::US20240109853, Compound A315::1-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 3-(1-hydroxypropan- 2-yl)urea::US20240226094, Compound A320::US20250241908, Compound A315::US20250381196, Compound A315 Alpha-protein kinase 1 Homo sapiens 261 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662401 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662401&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407518 496703673 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120220 CC(CO)NC(=O)Nc1nc(cs1)[C@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O2S/c1-4-17(3,12-5-7-13(18)8-6-12)14-10-24-16(20-14)21-15(23)19-11(2)9-22/h1,5-8,10-11,22H,9H2,2-3H3,(H2,19,20,21,23) YZORPNPHOCDTPW-UHFFFAOYSA-N 662401 US20240109853, Compound A314::US20240109853, Compound A315::1-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 3-(1-hydroxypropan- 2-yl)urea::US20240226094, Compound A320::US20250241908, Compound A315::US20250381196, Compound A315 Alpha-protein kinase 1 Homo sapiens 81.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662401 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662401&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407518 496703673 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120222 CC(O)CNC(=O)Nc1nc(cs1)[C@@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O2S/c1-4-17(3,12-5-7-13(18)8-6-12)14-10-24-16(20-14)21-15(23)19-9-11(2)22/h1,5-8,10-11,22H,9H2,2-3H3,(H2,19,20,21,23) RLVZJFYZWJNGGP-UHFFFAOYSA-N 662404 US20240109853, Compound A317::1-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 3-(2- hydroxypropyl)urea::US20240109853, Compound A319::US20240226094, Compound A324::US20250381196, Compound A319 Alpha-protein kinase 1 Homo sapiens 85.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662404&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407389 496703675 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120224 CC(O)CNC(=O)Nc1nc(cs1)[C@@](C)(C#C)c1ccc(Cl)cc1 |r| InChI=1S/C17H18ClN3O2S/c1-4-17(3,12-5-7-13(18)8-6-12)14-10-24-16(20-14)21-15(23)19-9-11(2)22/h1,5-8,10-11,22H,9H2,2-3H3,(H2,19,20,21,23) RLVZJFYZWJNGGP-UHFFFAOYSA-N 662404 US20240109853, Compound A317::1-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 3-(2- hydroxypropyl)urea::US20240109853, Compound A319::US20240226094, Compound A324::US20250381196, Compound A319 Alpha-protein kinase 1 Homo sapiens 156 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662404&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407389 496703675 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120225 [2H]C([2H])(O)CNC(=O)Nc1nc([C@](C)(C#C)c2ccc(Cl)cc2)cs1 InChI=1S/C16H16ClN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22)/i9D2 IQPXNEQCZAHNPG-KNXIQCGSSA-N 761339 1-[4-[1-(4-chlorophenyl)- 1-methyl-prop-2-nyl] thiazol-2-yl]-3-(2,2- dideuterio-2-hydroxy- ethyl)urea::US20250241908, Compound A320::US20250381196, Compound A320 Alpha-protein kinase 1 Homo sapiens 44.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=761339 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=761339&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407679 520671606 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120226 [2H]C([2H])(O)CNC(=O)Nc1nc([C@@](C)(C#C)c2ccc(Cl)cc2)cs1 InChI=1S/C16H16ClN3O2S/c1-3-16(2,11-4-6-12(17)7-5-11)13-10-23-15(19-13)20-14(22)18-8-9-21/h1,4-7,10,21H,8-9H2,2H3,(H2,18,19,20,22)/i9D2 IQPXNEQCZAHNPG-KNXIQCGSSA-N 761340 1-[4-[1-(4-chlorophenyl)- 1-methyl-prop-2-ynyl] thiazol-2-yl]-3-(2,2- dideuterio-2-hydroxy- ethyl)urea::US20250241908, Compound A321::US20250381196, Compound A321 Alpha-protein kinase 1 Homo sapiens 28.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=761340 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=761340&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407380 520671607 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120227 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1 InChI=1S/C24H28N4O2S/c1-24(2,18-6-10-20(30-3)11-7-18)21-16-31-23(26-21)27-22(29)17-4-8-19(9-5-17)28-14-12-25-13-15-28/h4-11,16,25H,12-15H2,1-3H3,(H,26,27,29) LNYLHMVYDHUVPP-UHFFFAOYSA-N 662409 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- yl)benzamide::US20240109853, Compound B001::US20240226094, Compound B001::US20250241908, Compound B044::US20250381196, Compound B047 Alpha-protein kinase 1 Homo sapiens 123 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662409&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407633 496703676 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120228 CC(C)(c1csc(NC(=O)c2ccc3[nH]ccc3c2)n1)c1ccc(Br)cc1 InChI=1S/C21H18BrN3OS/c1-21(2,15-4-6-16(22)7-5-15)18-12-27-20(24-18)25-19(26)14-3-8-17-13(11-14)9-10-23-17/h3-12,23H,1-2H3,(H,24,25,26) JXZPALJTTNJVQZ-UHFFFAOYSA-N 662410 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-1H-indole-5- carboxamide::US20240109853, Compound B002::US20240226094, Compound B002::US20250241908, Compound B002::US20250381196, Compound B002 Alpha-protein kinase 1 Homo sapiens 206 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662410 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662410&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407540 496703677 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120229 CC(C)(c1csc(NC(=O)c2ccc(cc2)C(N)=O)n1)c1ccc(Br)cc1 InChI=1S/C20H18BrN3O2S/c1-20(2,14-7-9-15(21)10-8-14)16-11-27-19(23-16)24-18(26)13-5-3-12(4-6-13)17(22)25/h3-11H,1-2H3,(H2,22,25)(H,23,24,26) IXTPVUGMSKFHSZ-UHFFFAOYSA-N 662411 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2- yl)terephthalamide::US20240109853, Compound B003::US20240226094, Compound B003::US20250241908, Compound B003::US20250381196, Compound B003 Alpha-protein kinase 1 Homo sapiens 192 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662411 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662411&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407387 496703678 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120230 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cccc(c2)N2CCNCC2)n1 InChI=1S/C24H28N4O2S/c1-24(2,18-7-9-20(30-3)10-8-18)21-16-31-23(26-21)27-22(29)17-5-4-6-19(15-17)28-13-11-25-12-14-28/h4-10,15-16,25H,11-14H2,1-3H3,(H,26,27,29) AOKHSBFBADQAMH-UHFFFAOYSA-N 662412 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-3-(piperazin-1- yl)benzamide::US20240109853, Compound B004::US20240226094, Compound B004::US20250241908, Compound B004::US20250381196, Compound B004 Alpha-protein kinase 1 Homo sapiens 211 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662412 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662412&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407620 496703679 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120231 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cccc(CN3CCNCC3)c2)n1 InChI=1S/C25H30N4O2S/c1-25(2,20-7-9-21(31-3)10-8-20)22-17-32-24(27-22)28-23(30)19-6-4-5-18(15-19)16-29-13-11-26-12-14-29/h4-10,15,17,26H,11-14,16H2,1-3H3,(H,27,28,30) PXTGAWVPSCKVMJ-UHFFFAOYSA-N 662413 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-3-(piperazin-1- ylmethyl)benzamide::US20240109853, Compound B005::US20240226094, Compound B005::US20250241908, Compound B005::US20250381196, Compound B005 Alpha-protein kinase 1 Homo sapiens 215 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662413 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662413&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407689 496703680 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120232 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCN(CCO)CC2)n1 InChI=1S/C26H32N4O3S/c1-26(2,20-6-10-22(33-3)11-7-20)23-18-34-25(27-23)28-24(32)19-4-8-21(9-5-19)30-14-12-29(13-15-30)16-17-31/h4-11,18,31H,12-17H2,1-3H3,(H,27,28,32) JQPHNIZQLXXUIT-UHFFFAOYSA-N 662414 4-(4-(2- hydroxyethyl)piperazin-1-yl)- N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B006::US20240226094, Compound B006::US20250241908, Compound B006::US20250381196, Compound B006 Alpha-protein kinase 1 Homo sapiens 595 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662414&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407409 496703681 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120233 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cccc(c2)N2CCN(CCO)CC2)n1 InChI=1S/C26H32N4O3S/c1-26(2,20-7-9-22(33-3)10-8-20)23-18-34-25(27-23)28-24(32)19-5-4-6-21(17-19)30-13-11-29(12-14-30)15-16-31/h4-10,17-18,31H,11-16H2,1-3H3,(H,27,28,32) IMWFUUXOHKFOBE-UHFFFAOYSA-N 662415 3-(4-(2- hydroxyethyl)piperazin-1-yl)- N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B007::US20240226094, Compound B007::US20250241908, Compound B007::US20250381196, Compound B007 Alpha-protein kinase 1 Homo sapiens 230 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662415&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407680 496703682 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120234 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2Cl)N2CCNCC2)n1 InChI=1S/C24H27ClN4O2S/c1-24(2,16-4-7-18(31-3)8-5-16)21-15-32-23(27-21)28-22(30)19-9-6-17(14-20(19)25)29-12-10-26-11-13-29/h4-9,14-15,26H,10-13H2,1-3H3,(H,27,28,30) XBAHWCROZCHEOG-UHFFFAOYSA-N 662416 2-chloro-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- yl)benzamide::US20240109853, Compound B008::US20240226094, Compound B008::US20250241908, Compound B008::US20250381196, Compound B008 Alpha-protein kinase 1 Homo sapiens 37.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662416&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407725 496703683 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120235 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCC(O)C2)n1 InChI=1S/C24H27N3O3S/c1-24(2,17-6-10-20(30-3)11-7-17)21-15-31-23(25-21)26-22(29)16-4-8-18(9-5-16)27-13-12-19(28)14-27/h4-11,15,19,28H,12-14H2,1-3H3,(H,25,26,29) PYIUQAKJZGVMKW-UHFFFAOYSA-N 662417 4-(3-hydroxypyrrolidin-1-yl)- N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B009::US20240226094, Compound B009::US20250241908, Compound B009::US20250381196, Compound B009 Alpha-protein kinase 1 Homo sapiens 95.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662417&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407728 496703684 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120236 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(nc2)N2CCC(C2)N(C)C)n1 InChI=1S/C25H31N5O2S/c1-25(2,18-7-9-20(32-5)10-8-18)21-16-33-24(27-21)28-23(31)17-6-11-22(26-14-17)30-13-12-19(15-30)29(3)4/h6-11,14,16,19H,12-13,15H2,1-5H3,(H,27,28,31) LDVLVECPKXIROG-UHFFFAOYSA-N 662418 6-(3- (dimethylamino)pyrrolidin-1- yl)-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)nicotinamide::US20240109853, Compound B010::US20240226094, Compound B010::US20250241908, Compound B010::US20250381196, Compound B010 Alpha-protein kinase 1 Homo sapiens 187 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662418&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407445 496703685 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120237 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cccc(OCCCCN3CCNCC3)c2)n1 InChI=1S/C28H36N4O3S/c1-28(2,22-9-11-23(34-3)12-10-22)25-20-36-27(30-25)31-26(33)21-7-6-8-24(19-21)35-18-5-4-15-32-16-13-29-14-17-32/h6-12,19-20,29H,4-5,13-18H2,1-3H3,(H,30,31,33) XQVYVTZYBBBSDS-UHFFFAOYSA-N 662419 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-3-(4- (piperazin-1- yl)butoxy)benzamide::US20240109853, Compound B011::US20250241908, Compound B011::US20250381196, Compound B011 Alpha-protein kinase 1 Homo sapiens 230 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662419&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407551 496703686 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120238 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCNC(C)C2)n1 InChI=1S/C25H30N4O2S/c1-17-15-29(14-13-26-17)20-9-5-18(6-10-20)23(30)28-24-27-22(16-32-24)25(2,3)19-7-11-21(31-4)12-8-19/h5-12,16-17,26H,13-15H2,1-4H3,(H,27,28,30) AWXSOTCHDFZQIM-UHFFFAOYSA-N 662420 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(3- methylpiperazin-1- yl)benzamide::US20240109853, Compound B012::US20240226094, Compound B012::US20250241908, Compound B012::US20250381196, Compound B012 Alpha-protein kinase 1 Homo sapiens 118 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662420&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407669 496703687 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120239 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(CN3CCNCC3)cc2F)n1 InChI=1S/C25H29FN4O2S/c1-25(2,18-5-7-19(32-3)8-6-18)22-16-33-24(28-22)29-23(31)20-9-4-17(14-21(20)26)15-30-12-10-27-11-13-30/h4-9,14,16,27H,10-13,15H2,1-3H3,(H,28,29,31) SXUZQKPPKOCPRI-UHFFFAOYSA-N 662421 2-fluoro-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- ylmethyl)benzamide::US20240109853, Compound B013::US20240226094, Compound B013::US20250241908, Compound B013::US20250381196, Compound B013 Alpha-protein kinase 1 Homo sapiens 111 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662421&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407871 496703688 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120240 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCNCC2C)n1 InChI=1S/C25H30N4O2S/c1-17-15-26-13-14-29(17)20-9-5-18(6-10-20)23(30)28-24-27-22(16-32-24)25(2,3)19-7-11-21(31-4)12-8-19/h5-12,16-17,26H,13-15H2,1-4H3,(H,27,28,30) ZUZOXQSUIVJSAL-UHFFFAOYSA-N 662422 tert-butyl 4-(4-((4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2- yl)carbamoyl)phenyl)-3- methylpiperazine-1- carboxylate::US20240109853, Compound B014::US20240226094, Compound B014::US20250241908, Compound B014::US20250381196, Compound B014 Alpha-protein kinase 1 Homo sapiens 300 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662422&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407371 496703689 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120241 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cnc(nc2)N2CCNCC2)n1 InChI=1S/C22H26N6O2S/c1-22(2,16-4-6-17(30-3)7-5-16)18-14-31-21(26-18)27-19(29)15-12-24-20(25-13-15)28-10-8-23-9-11-28/h4-7,12-14,23H,8-11H2,1-3H3,(H,26,27,29) JAZMABMJVLRGJB-UHFFFAOYSA-N 662423 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-2-(piperazin-1- yl)pyrimidine-5-carboxamide::US20240109853, Compound B015::US20240226094, Compound B015::US20250241908, Compound B015::US20250381196, Compound B015 Alpha-protein kinase 1 Homo sapiens 161 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662423&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407587 496703690 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120242 CC(C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C23H25BrN4OS/c1-23(2,17-5-7-18(24)8-6-17)20-15-30-22(26-20)27-21(29)16-3-9-19(10-4-16)28-13-11-25-12-14-28/h3-10,15,25H,11-14H2,1-2H3,(H,26,27,29) SPMNRSVSPZETEL-UHFFFAOYSA-N 662424 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- yl)benzamide::US20240109853, Compound B016::US20240226094, Compound B016::US20250241908, Compound B016::US20250381196, Compound B016 Alpha-protein kinase 1 Homo sapiens 60.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662424&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407504 496703691 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120243 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(CN3CCN(C)CC3)cc2)n1 InChI=1S/C26H32N4O2S/c1-26(2,21-9-11-22(32-4)12-10-21)23-18-33-25(27-23)28-24(31)20-7-5-19(6-8-20)17-30-15-13-29(3)14-16-30/h5-12,18H,13-17H2,1-4H3,(H,27,28,31) HXWQKVFTKYUSRH-UHFFFAOYSA-N 662425 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-((4- methylpiperazin-1- yl)methyl)benzamide::US20240109853, Compound B017::US20240226094, Compound B017::US20250241908, Compound B017::US20250381196, Compound B017 Alpha-protein kinase 1 Homo sapiens 148 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662425&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407727 496703692 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120244 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cccc(CN3CCN(CCO)CC3)c2)n1 InChI=1S/C27H34N4O3S/c1-27(2,22-7-9-23(34-3)10-8-22)24-19-35-26(28-24)29-25(33)21-6-4-5-20(17-21)18-31-13-11-30(12-14-31)15-16-32/h4-10,17,19,32H,11-16,18H2,1-3H3,(H,28,29,33) ZHEBRMKTYJTASG-UHFFFAOYSA-N 662426 3-((4-(2- hydroxyethyl)piperazin-1- yl)methyl)-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B018::US20240226094, Compound B018::US20250241908, Compound B018::US20250381196, Compound B018 Alpha-protein kinase 1 Homo sapiens 187 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662426 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662426&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407414 496703693 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120245 CC(N1CCNCC1)c1ccc(cc1)C(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1 InChI=1S/C25H29BrN4OS/c1-17(30-14-12-27-13-15-30)18-4-6-19(7-5-18)23(31)29-24-28-22(16-32-24)25(2,3)20-8-10-21(26)11-9-20/h4-11,16-17,27H,12-15H2,1-3H3,(H,28,29,31) QLNSGNQNASQXSQ-UHFFFAOYSA-N 662427 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-4-(1- (piperazin-1- yl)ethyl)benzamide::US20240109853, Compound B019::US20240226094, Compound B019::US20250241908, Compound B019::US20250381196, Compound B019 Alpha-protein kinase 1 Homo sapiens 98.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662427&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407638 496703694 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120246 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(OC3CCN(CCO)CC3)cc2)n1 InChI=1S/C27H33N3O4S/c1-27(2,20-6-10-21(33-3)11-7-20)24-18-35-26(28-24)29-25(32)19-4-8-22(9-5-19)34-23-12-14-30(15-13-23)16-17-31/h4-11,18,23,31H,12-17H2,1-3H3,(H,28,29,32) UZIFZXLJVYAWPI-UHFFFAOYSA-N 662428 4-((1-(2- hydroxyethyl)piperidin-4- yl)oxy)-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B020::US20240226094, Compound B020::US20250241908, Compound B020::US20250381196, Compound B020 Alpha-protein kinase 1 Homo sapiens 170 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662428&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407556 496703695 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120247 COc3ccc(C(C)(C)c2csc(NC(=O)c1ccc(OCCN(C)C)cc1)n2)cc3 InChI=1S/C24H29N3O3S/c1-24(2,18-8-12-19(29-5)13-9-18)21-16-31-23(25-21)26-22(28)17-6-10-20(11-7-17)30-15-14-27(3)4/h6-13,16H,14-15H2,1-5H3,(H,25,26,28) RFYIYXRUEHWUJQ-UHFFFAOYSA-N 662437 4-(2-(dimethylamino)ethoxy)- N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B029::US20250241908, Compound B029::US20250381196, Compound B029 Alpha-protein kinase 1 Homo sapiens 83.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662437&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120248 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(OCCCN3CCNCC3)cc2)n1 InChI=1S/C27H34N4O3S/c1-27(2,21-7-11-22(33-3)12-8-21)24-19-35-26(29-24)30-25(32)20-5-9-23(10-6-20)34-18-4-15-31-16-13-28-14-17-31/h5-12,19,28H,4,13-18H2,1-3H3,(H,29,30,32) GAIPTJWDUCWSOM-UHFFFAOYSA-N 662430 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(3- (piperazin-1- yl)propoxy)benzamide::US20240109853, Compound B022::US20240226094, Compound B022::US20250241908, Compound B022::US20250381196, Compound B022 Alpha-protein kinase 1 Homo sapiens 294 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662430 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662430&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407404 496703697 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120249 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cccc(OCCCN3CCNCC3)c2)n1 InChI=1S/C27H34N4O3S/c1-27(2,21-8-10-22(33-3)11-9-21)24-19-35-26(29-24)30-25(32)20-6-4-7-23(18-20)34-17-5-14-31-15-12-28-13-16-31/h4,6-11,18-19,28H,5,12-17H2,1-3H3,(H,29,30,32) NCURZOOFHCSQTR-UHFFFAOYSA-N 662431 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-3-(3- (piperazin-1- yl)propoxy)benzamide::US20240109853, Compound B023::US20240226094, Compound B023::US20250241908, Compound B023::US20250381196, Compound B023 Alpha-protein kinase 1 Homo sapiens 150 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662431 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662431&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407799 496703698 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120250 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(OCCN3CCNCC3)cc2)n1 InChI=1S/C26H32N4O3S/c1-26(2,20-6-10-21(32-3)11-7-20)23-18-34-25(28-23)29-24(31)19-4-8-22(9-5-19)33-17-16-30-14-12-27-13-15-30/h4-11,18,27H,12-17H2,1-3H3,(H,28,29,31) QTEZLTNWVTZKDT-UHFFFAOYSA-N 662432 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(2- (piperazin-1- yl)ethoxy)benzamide::US20240109853, Compound B024::US20240226094, Compound B024::US20250241908, Compound B024::US20250381196, Compound B024 Alpha-protein kinase 1 Homo sapiens 116 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662432&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407813 496703699 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120251 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cnc(cn2)N2CCNCC2)n1 InChI=1S/C22H26N6O2S/c1-22(2,15-4-6-16(30-3)7-5-15)18-14-31-21(26-18)27-20(29)17-12-25-19(13-24-17)28-10-8-23-9-11-28/h4-7,12-14,23H,8-11H2,1-3H3,(H,26,27,29) PSPUHWGBUNGGTC-UHFFFAOYSA-N 662433 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-5-(piperazin-1- yl)pyrazine-2-carboxamide::US20240109853, Compound B025::US20240226094, Compound B025::US20250241908, Compound B025::US20250381196, Compound B025 Alpha-protein kinase 1 Homo sapiens 298 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662433 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662433&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407666 496703700 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120252 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(CN3CCNCC3C)cc2)n1 InChI=1S/C26H32N4O2S/c1-18-15-27-13-14-30(18)16-19-5-7-20(8-6-19)24(31)29-25-28-23(17-33-25)26(2,3)21-9-11-22(32-4)12-10-21/h5-12,17-18,27H,13-16H2,1-4H3,(H,28,29,31) GSHGABGVGQPWDP-UHFFFAOYSA-N 662434 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-((2- methylpiperazin-1- yl)methyl)benzamide::US20240109853, Compound B026::US20240226094, Compound B026::US20250241908, Compound B026::US20250381196, Compound B026 Alpha-protein kinase 1 Homo sapiens 127 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662434&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407649 496703701 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120253 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCC(C2)N(C)C)n1 InChI=1S/C26H32N4O2S/c1-26(2,19-8-12-22(32-5)13-9-19)23-17-33-25(27-23)28-24(31)18-6-10-20(11-7-18)30-15-14-21(16-30)29(3)4/h6-13,17,21H,14-16H2,1-5H3,(H,27,28,31) XUAFISJQFSRXEJ-UHFFFAOYSA-N 662435 4-(3- (dimethylamino)pyrrolidin-1- yl)-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B027::US20250241908, Compound B027::US20250381196, Compound B027 Alpha-protein kinase 1 Homo sapiens 219 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662435 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662435&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407622 496703702 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120254 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(NC3CCN(C)CC3)cc2)n1 InChI=1S/C26H32N4O2S/c1-26(2,19-7-11-22(32-4)12-8-19)23-17-33-25(28-23)29-24(31)18-5-9-20(10-6-18)27-21-13-15-30(3)16-14-21/h5-12,17,21,27H,13-16H2,1-4H3,(H,28,29,31) HMRGKYJBPSIRCJ-UHFFFAOYSA-N 662436 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-((1- methylpiperidin-4- yl)amino)benzamide::US20240109853, Compound B028::US20240226094, Compound B028::US20250241908, Compound B028::US20250381196, Compound B028 Alpha-protein kinase 1 Homo sapiens 271 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662436&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407841 496703703 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120255 COc3ccc(C(C)(C)c2csc(NC(=O)c1ccc(OCCN(C)C)cc1)n2)cc3 InChI=1S/C24H29N3O3S/c1-24(2,18-8-12-19(29-5)13-9-18)21-16-31-23(25-21)26-22(28)17-6-10-20(11-7-17)30-15-14-27(3)4/h6-13,16H,14-15H2,1-5H3,(H,25,26,28) RFYIYXRUEHWUJQ-UHFFFAOYSA-N 662437 4-(2-(dimethylamino)ethoxy)- N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B029::US20250241908, Compound B029::US20250381196, Compound B029 Alpha-protein kinase 1 Homo sapiens 83.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662437&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120256 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)C(=O)NC2CCN(C)CC2)n1 InChI=1S/C27H32N4O3S/c1-27(2,20-9-11-22(34-4)12-10-20)23-17-35-26(29-23)30-25(33)19-7-5-18(6-8-19)24(32)28-21-13-15-31(3)16-14-21/h5-12,17,21H,13-16H2,1-4H3,(H,28,32)(H,29,30,33) UBUOHNBWOHDXSU-UHFFFAOYSA-N 662438 N1-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-N4-(1- methylpiperidin-4- yl)terephthalamide::US20240109853, Compound B030::US20240226094, Compound B030::US20250381196, Compound B030 Alpha-protein kinase 1 Homo sapiens 155 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662438&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407665 496703704 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120257 Cc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1 InChI=1S/C24H28N4OS/c1-17-4-8-19(9-5-17)24(2,3)21-16-30-23(26-21)27-22(29)18-6-10-20(11-7-18)28-14-12-25-13-15-28/h4-11,16,25H,12-15H2,1-3H3,(H,26,27,29) GCXIPPBIGKRPEQ-UHFFFAOYSA-N 662439 4-(piperazin-1-yl)-N-(4-(2-(p- tolyl)propan-2-yl)thiazol-2- yl)benzamide::US20240109853, Compound B031::US20240226094, Compound B031::US20250241908, Compound B031::US20250381196, Compound B031 Alpha-protein kinase 1 Homo sapiens 37.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662439&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407693 496703705 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120258 COc3ccc(C(C)(C)c2csc(NC(=O)c1ccc(NCCO)cc1)n2)cc3 InChI=1S/C22H25N3O3S/c1-22(2,16-6-10-18(28-3)11-7-16)19-14-29-21(24-19)25-20(27)15-4-8-17(9-5-15)23-12-13-26/h4-11,14,23,26H,12-13H2,1-3H3,(H,24,25,27) FGGNZCBVWNHSRZ-UHFFFAOYSA-N 662468 4-((2-hydroxyethyl)amino)-N- (4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B060::US20250241908, Compound B060::US20250381196, Compound B060 Alpha-protein kinase 1 Homo sapiens 280 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662468 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662468&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120259 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(NCCN)cc2)n1 InChI=1S/C22H26N4O2S/c1-22(2,16-6-10-18(28-3)11-7-16)19-14-29-21(25-19)26-20(27)15-4-8-17(9-5-15)24-13-12-23/h4-11,14,24H,12-13,23H2,1-3H3,(H,25,26,27) UDMVXQXHEPGBFX-UHFFFAOYSA-N 662441 4-((2-aminoethyl)amino)-N- (4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B033::US20240226094, Compound B033::US20250241908, Compound B033::US20250381196, Compound B033 Alpha-protein kinase 1 Homo sapiens 247 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662441 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662441&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407427 496703707 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120260 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(CN3CCN(CCO)CC3)cc2)n1 InChI=1S/C27H34N4O3S/c1-27(2,22-8-10-23(34-3)11-9-22)24-19-35-26(28-24)29-25(33)21-6-4-20(5-7-21)18-31-14-12-30(13-15-31)16-17-32/h4-11,19,32H,12-18H2,1-3H3,(H,28,29,33) BQMDJFXDFQRSMC-UHFFFAOYSA-N 662442 4-((4-(2- hydroxyethyl)piperazin-1- yl)methyl)-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B034::US20240226094, Compound B034::US20250241908, Compound B034::US20250381196, Compound B034 Alpha-protein kinase 1 Homo sapiens 44.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662442 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662442&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221896 496703708 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120261 CC(C)(c1csc(NC(=O)c2ccc(nc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C22H24BrN5OS/c1-22(2,16-4-6-17(23)7-5-16)18-14-30-21(26-18)27-20(29)15-3-8-19(25-13-15)28-11-9-24-10-12-28/h3-8,13-14,24H,9-12H2,1-2H3,(H,26,27,29) VOOSOCWCDDHSOD-UHFFFAOYSA-N 662443 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-6-(piperazin-1- yl)nicotinamide::US20240109853, Compound B035::US20240226094, Compound B035::US20250241908, Compound B035::US20250381196, Compound B035 Alpha-protein kinase 1 Homo sapiens 75.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662443 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662443&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407582 496703709 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120262 CC(C)(c1csc(NC(=O)c2cnc(nc2)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C21H23BrN6OS/c1-21(2,15-3-5-16(22)6-4-15)17-13-30-20(26-17)27-18(29)14-11-24-19(25-12-14)28-9-7-23-8-10-28/h3-6,11-13,23H,7-10H2,1-2H3,(H,26,27,29) KNTLFMPVAUGFRP-UHFFFAOYSA-N 662444 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-2-(piperazin-1- yl)pyrimidine-5-carboxamide::US20240109853, Compound B036::US20240226094, Compound B036::US20250241908, Compound B036::US20250381196, Compound B036 Alpha-protein kinase 1 Homo sapiens 110 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662444&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407521 496703710 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120263 CC(C)(c1csc(NC(=O)NCc2cc(F)c(N3CCNCC3)c(F)c2)n1)c1ccc(Br)cc1 InChI=1S/C24H26BrF2N5OS/c1-24(2,16-3-5-17(25)6-4-16)20-14-34-23(30-20)31-22(33)29-13-15-11-18(26)21(19(27)12-15)32-9-7-28-8-10-32/h3-6,11-12,14,28H,7-10,13H2,1-2H3,(H2,29,30,31,33) GPUCDMDGRMFTLX-UHFFFAOYSA-N 662445 1-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-3-(3,5- difluoro-4-(piperazin-1- yl)benzyl)urea::US20240109853, Compound B037::US20240226094, Compound B037::US20250241908, Compound B037::US20250381196, Compound B037 Alpha-protein kinase 1 Homo sapiens 23.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662445 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662445&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407413 496703711 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120264 COc1ccc(cc1)C(C)(C)c1cnc(NC(=O)c2ccc(N3CCNCC3)c(F)c2)s1 InChI=1S/C24H27FN4O2S/c1-24(2,17-5-7-18(31-3)8-6-17)21-15-27-23(32-21)28-22(30)16-4-9-20(19(25)14-16)29-12-10-26-11-13-29/h4-9,14-15,26H,10-13H2,1-3H3,(H,27,28,30) HAIQDXNIOFXSPT-UHFFFAOYSA-N 662446 3-fluoro-N-(5-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- yl)benzamide::US20240109853, Compound B038::US20250241908, Compound B038::US20250381196, Compound B038 Alpha-protein kinase 1 Homo sapiens 216 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662446 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662446&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407590 496703712 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120265 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(N3CCNCC3)c(OC)c2)n1 InChI=1S/C25H30N4O3S/c1-25(2,18-6-8-19(31-3)9-7-18)22-16-33-24(27-22)28-23(30)17-5-10-20(21(15-17)32-4)29-13-11-26-12-14-29/h5-10,15-16,26H,11-14H2,1-4H3,(H,27,28,30) OYGDYCZCUCSTJH-UHFFFAOYSA-N 662447 3-methoxy-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- yl)benzamide::US20240109853, Compound B039::US20240226094, Compound B039::US20250241908, Compound B039::US20250381196, Compound B039 Alpha-protein kinase 1 Homo sapiens 123 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662447 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662447&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407645 496703713 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120266 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(CN3CCNCC3)cc2)n1 InChI=1S/C25H30N4O2S/c1-25(2,20-8-10-21(31-3)11-9-20)22-17-32-24(27-22)28-23(30)19-6-4-18(5-7-19)16-29-14-12-26-13-15-29/h4-11,17,26H,12-16H2,1-3H3,(H,27,28,30) HWXNPHHQXACFJL-UHFFFAOYSA-N 662448 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- ylmethyl)benzamide::US20240109853, Compound B040::US20240226094, Compound B040::US20250241908, Compound B040::US20250381196, Compound B040 Alpha-protein kinase 1 Homo sapiens 93.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662448 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662448&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407712 496703714 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120267 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCC(N)C2)n1 InChI=1S/C24H28N4O2S/c1-24(2,17-6-10-20(30-3)11-7-17)21-15-31-23(26-21)27-22(29)16-4-8-19(9-5-16)28-13-12-18(25)14-28/h4-11,15,18H,12-14,25H2,1-3H3,(H,26,27,29) NQFRFNHDPIUKDN-UHFFFAOYSA-N 662449 4-(3-aminopyrrolidin-1-yl)-N- (4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B041::US20240226094, Compound B041::US20250241908, Compound B043::US20250381196, Compound B041 Alpha-protein kinase 1 Homo sapiens 80.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662449 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662449&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407483 496703715 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120268 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(nc2)N2CCNCC2)n1 InChI=1S/C23H27N5O2S/c1-23(2,17-5-7-18(30-3)8-6-17)19-15-31-22(26-19)27-21(29)16-4-9-20(25-14-16)28-12-10-24-11-13-28/h4-9,14-15,24H,10-13H2,1-3H3,(H,26,27,29) XJKKSACEAKWNLN-UHFFFAOYSA-N 662450 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-6-(piperazin-1- yl)nicotinamide::US20240109853, Compound B042::US20240226094, Compound B042::US20250241908, Compound B042::US20250381196, Compound B042 Alpha-protein kinase 1 Homo sapiens 86.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662450 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662450&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407753 496703716 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120269 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(nc2)N2CCC(N)C2)n1 InChI=1S/C23H27N5O2S/c1-23(2,16-5-7-18(30-3)8-6-16)19-14-31-22(26-19)27-21(29)15-4-9-20(25-12-15)28-11-10-17(24)13-28/h4-9,12,14,17H,10-11,13,24H2,1-3H3,(H,26,27,29) WNAZCXSPCIDPSW-UHFFFAOYSA-N 662451 6-(3-aminopyrrolidin-1-yl)-N- (4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)nicotinamide::US20240109853, Compound B043::US20240226094, Compound B043::US20250381196, Compound B043 Alpha-protein kinase 1 Homo sapiens 140 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662451 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662451&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407609 496703717 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120270 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cn2)N2CCNCC2)n1 InChI=1S/C23H27N5O2S/c1-23(2,16-4-7-18(30-3)8-5-16)20-15-31-22(26-20)27-21(29)19-9-6-17(14-25-19)28-12-10-24-11-13-28/h4-9,14-15,24H,10-13H2,1-3H3,(H,26,27,29) MYFHEGYLRWQMIL-UHFFFAOYSA-N 662452 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-5-(piperazin-1- yl)picolinamide::US20240109853, Compound B044::US20240226094, Compound B044::US20250381196, Compound B044 Alpha-protein kinase 1 Homo sapiens 213 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662452&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407706 496703718 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120271 Cc1ccc(C(C)(C)c2csc(NC(=O)NCc3ccc(N4CCNCC4)nc3)n2)cc1 InChI=1S/C24H30N6OS/c1-17-4-7-19(8-5-17)24(2,3)20-16-32-23(28-20)29-22(31)27-15-18-6-9-21(26-14-18)30-12-10-25-11-13-30/h4-9,14,16,25H,10-13,15H2,1-3H3,(H2,27,28,29,31) KNOLJPLCCWNJRC-UHFFFAOYSA-N 79464 6-(piperazin-1- yl)-N-(4-(2-(p- tolyl)propan-2- yl)thiazol-2-yl)- nicotinamide::US20250381196, Compound B045 Alpha-protein kinase 1 Homo sapiens 30.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79464 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79464&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 3536865 252656118 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120272 CN1CCN(Cc2ccc(cc2)C(=O)Nc2nc(cs2)C(C)(C)c2ccc(C)cc2)CC1 InChI=1S/C26H32N4OS/c1-19-5-11-22(12-6-19)26(2,3)23-18-32-25(27-23)28-24(31)21-9-7-20(8-10-21)17-30-15-13-29(4)14-16-30/h5-12,18H,13-17H2,1-4H3,(H,27,28,31) HIEJMDUAYKWHKR-UHFFFAOYSA-N 662454 4-((4-methylpiperazin-1- yl)methyl)-N-(4-(2-(p- tolyl)propan-2-yl)thiazol-2- yl)benzamide::US20240109853, Compound B046::US20240226094, Compound B046::US20250241908, Compound B046::US20250381196, Compound B046 Alpha-protein kinase 1 Homo sapiens 28.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662454 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662454&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407485 496703720 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120273 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1 InChI=1S/C24H28N4O2S/c1-24(2,18-6-10-20(30-3)11-7-18)21-16-31-23(26-21)27-22(29)17-4-8-19(9-5-17)28-14-12-25-13-15-28/h4-11,16,25H,12-15H2,1-3H3,(H,26,27,29) LNYLHMVYDHUVPP-UHFFFAOYSA-N 662409 N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- yl)benzamide::US20240109853, Compound B001::US20240226094, Compound B001::US20250241908, Compound B044::US20250381196, Compound B047 Alpha-protein kinase 1 Homo sapiens 128 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662409&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407633 496703676 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120274 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)N2CC3CC(C2)N3)n1 InChI=1S/C25H28N4O2S/c1-25(2,17-6-10-21(31-3)11-7-17)22-15-32-24(27-22)28-23(30)16-4-8-20(9-5-16)29-13-18-12-19(14-29)26-18/h4-11,15,18-19,26H,12-14H2,1-3H3,(H,27,28,30) OSRJCDKHFIOGRA-UHFFFAOYSA-N 662456 4-(3,6- diazabicyclo[3.1.1]heptan-3- yl)-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B048::US20240226094, Compound B048::US20250241908, Compound B048::US20250381196, Compound B048 Alpha-protein kinase 1 Homo sapiens 73.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662456&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407736 496703722 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120275 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(cc2)C2(O)CCNCC2)n1 InChI=1S/C25H29N3O3S/c1-24(2,18-8-10-20(31-3)11-9-18)21-16-32-23(27-21)28-22(29)17-4-6-19(7-5-17)25(30)12-14-26-15-13-25/h4-11,16,26,30H,12-15H2,1-3H3,(H,27,28,29) DQRSZGFHDURVOG-UHFFFAOYSA-N 662457 4-(4-hydroxypiperidin-4-yl)- N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide hydrochloride::US20240109853, Compound B049::US20240226094, Compound B049::US20250381196, Compound B049 Alpha-protein kinase 1 Homo sapiens 459 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662457 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662457&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407565 496703723 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120276 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2cc(I)cc(I)c2O)n1 InChI=1S/C20H18I2N2O3S/c1-20(2,11-4-6-13(27-3)7-5-11)16-10-28-19(23-16)24-18(26)14-8-12(21)9-15(22)17(14)25/h4-10,25H,1-3H3,(H,23,24,26) MAXFISIUAXYGKY-UHFFFAOYSA-N 662458 2-hydroxy-3,5-diiodo-N-(4-(2- (4-methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B050::US20240226094, Compound B050::US20250241908, Compound B050::US20250381196, Compound B050 Alpha-protein kinase 1 Homo sapiens 77.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662458 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662458&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407420 496703724 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120277 CC(C)(c1csc(NC(=O)c2ccc(CN3CCN(CCO)CC3)nc2)n1)c1ccc(Br)cc1 InChI=1S/C25H30BrN5O2S/c1-25(2,19-4-6-20(26)7-5-19)22-17-34-24(28-22)29-23(33)18-3-8-21(27-15-18)16-31-11-9-30(10-12-31)13-14-32/h3-8,15,17,32H,9-14,16H2,1-2H3,(H,28,29,33) WGIBMUCWXCXVMR-UHFFFAOYSA-N 662459 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-6-((4-(2- hydroxyethyl)piperazin-1- yl)methyl)nicotinamide::US20240109853, Compound B051::US20240226094, Compound B051::US20250241908, Compound B051::US20250381196, Compound B051 Alpha-protein kinase 1 Homo sapiens 61.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662459&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407831 496703725 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120278 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(CN3CCN(CCO)CC3)nc2)n1 InChI=1S/C26H33N5O3S/c1-26(2,20-5-8-22(34-3)9-6-20)23-18-35-25(28-23)29-24(33)19-4-7-21(27-16-19)17-31-12-10-30(11-13-31)14-15-32/h4-9,16,18,32H,10-15,17H2,1-3H3,(H,28,29,33) RHPSNILROFBFED-UHFFFAOYSA-N 662460 6-((4-(2- hydroxyethyl)piperazin-1- yl)methyl)-N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)nicotinamide::US20240109853, Compound B052::US20240226094, Compound B052::US20250241908, Compound B052::US20250381196, Compound B052 Alpha-protein kinase 1 Homo sapiens 111 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662460&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407529 496703726 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120279 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(nc2)N2CCN(CCO)CC2)n1 InChI=1S/C25H31N5O3S/c1-25(2,19-5-7-20(33-3)8-6-19)21-17-34-24(27-21)28-23(32)18-4-9-22(26-16-18)30-12-10-29(11-13-30)14-15-31/h4-9,16-17,31H,10-15H2,1-3H3,(H,27,28,32) DQIFTHKSBAQJSE-UHFFFAOYSA-N 662461 6-(4-(2- hydroxyethyl)piperazin-1-yl)- N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)nicotinamide::US20240109853, Compound B053::US20240226094, Compound B053::US20250241908, Compound B053::US20250381196, Compound B053 Alpha-protein kinase 1 Homo sapiens 104 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662461&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407428 496703727 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120280 CC(C)(c1csc(NC(=O)c2ccc(nc2)N2CCN(CCO)CC2)n1)c1ccc(Br)cc1 InChI=1S/C24H28BrN5O2S/c1-24(2,18-4-6-19(25)7-5-18)20-16-33-23(27-20)28-22(32)17-3-8-21(26-15-17)30-11-9-29(10-12-30)13-14-31/h3-8,15-16,31H,9-14H2,1-2H3,(H,27,28,32) RLQQVEKQELTGRZ-UHFFFAOYSA-N 662462 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-6-(4-(2- hydroxyethyl)piperazin-1- yl)nicotinamide::US20240109853, Compound B054::US20240226094, Compound B054::US20250241908, Compound B054::US20250381196, Compound B054 Alpha-protein kinase 1 Homo sapiens 269 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662462&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407710 496703728 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120281 CN(C)CCNc1ccc(cn1)C(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1 InChI=1S/C22H26BrN5OS/c1-22(2,16-6-8-17(23)9-7-16)18-14-30-21(26-18)27-20(29)15-5-10-19(25-13-15)24-11-12-28(3)4/h5-10,13-14H,11-12H2,1-4H3,(H,24,25)(H,26,27,29) WEIKSDMSMNSOQF-UHFFFAOYSA-N 662463 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)-6-((2- (dimethylamino)ethyl)amino) nicotinamide::US20240109853, Compound B055::US20240226094, Compound B055::US20250241908, Compound B055::US20250381196, Compound B055 Alpha-protein kinase 1 Homo sapiens 125 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662463&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407816 496703729 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120282 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(NCCN(C)C)nc2)n1 InChI=1S/C23H29N5O2S/c1-23(2,17-7-9-18(30-5)10-8-17)19-15-31-22(26-19)27-21(29)16-6-11-20(25-14-16)24-12-13-28(3)4/h6-11,14-15H,12-13H2,1-5H3,(H,24,25)(H,26,27,29) JSORJIVXLAOIQL-UHFFFAOYSA-N 662464 6-((2- (dimethylamino)ethyl)amino)- N-(4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)nicotinamide::US20240109853, Compound B056::US20240226094, Compound B056::US20250241908, Compound B056::US20250381196, Compound B056 Alpha-protein kinase 1 Homo sapiens 120 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662464 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662464&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221914 496703730 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120283 COCCOc1cc(ccc1N1CCNCC1)C(=O)Nc1nc(cs1)C(C)(C)c1ccc(OC)cc1 InChI=1S/C27H34N4O4S/c1-27(2,20-6-8-21(34-4)9-7-20)24-18-36-26(29-24)30-25(32)19-5-10-22(31-13-11-28-12-14-31)23(17-19)35-16-15-33-3/h5-10,17-18,28H,11-16H2,1-4H3,(H,29,30,32) INRHLNNBGVKEOX-UHFFFAOYSA-N 662465 3-(2-methoxyethoxy)-N-(4-(2- (4-methoxyphenyl)propan-2- yl)thiazol-2-yl)-4-(piperazin-1- yl)benzamide hydrochloride::US20240109853, Compound B057::US20240226094, Compound B057::US20250241908, Compound B057::US20250381196, Compound B057 Alpha-protein kinase 1 Homo sapiens 103 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662465 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662465&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407422 496703731 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120284 Cc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(CN3CCN(CCO)CC3)cc2)n1 InChI=1S/C27H34N4O2S/c1-20-4-10-23(11-5-20)27(2,3)24-19-34-26(28-24)29-25(33)22-8-6-21(7-9-22)18-31-14-12-30(13-15-31)16-17-32/h4-11,19,32H,12-18H2,1-3H3,(H,28,29,33) KJWGVKDFGIRWJJ-UHFFFAOYSA-N 662466 4-((4-(2- hydroxyethyl)piperazin-1- yl)methyl)-N-(4-(2-(p- tolyl)propan-2-yl)thiazol-2- yl)benzamide::US20240109853, Compound B058::US20240226094, Compound B058::US20250241908, Compound B058::US20250381196, Compound B058 Alpha-protein kinase 1 Homo sapiens 68.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662466 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662466&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407448 496703732 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120285 Cc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(CN3CCN(CCO)CC3)nc2)n1 InChI=1S/C26H33N5O2S/c1-19-4-7-21(8-5-19)26(2,3)23-18-34-25(28-23)29-24(33)20-6-9-22(27-16-20)17-31-12-10-30(11-13-31)14-15-32/h4-9,16,18,32H,10-15,17H2,1-3H3,(H,28,29,33) DPXVBELTKYEGRJ-UHFFFAOYSA-N 662467 6-((4-(2- hydroxyethyl)piperazin-1- yl)methyl)-N-(4-(2-(p- tolyl)propan-2-yl)thiazol-2- yl)nicotinamide::US20240109853, Compound B059::US20240226094, Compound B059::US20250241908, Compound B059::US20250381196, Compound B059 Alpha-protein kinase 1 Homo sapiens 159 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662467 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662467&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221903 496703733 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120286 COc3ccc(C(C)(C)c2csc(NC(=O)c1ccc(NCCO)cc1)n2)cc3 InChI=1S/C22H25N3O3S/c1-22(2,16-6-10-18(28-3)11-7-16)19-14-29-21(24-19)25-20(27)15-4-8-17(9-5-15)23-12-13-26/h4-11,14,23,26H,12-13H2,1-3H3,(H,24,25,27) FGGNZCBVWNHSRZ-UHFFFAOYSA-N 662468 4-((2-hydroxyethyl)amino)-N- (4-(2-(4- methoxyphenyl)propan-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B060::US20250241908, Compound B060::US20250381196, Compound B060 Alpha-protein kinase 1 Homo sapiens 280 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662468 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662468&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120287 CC(C#C)(c1csc(NC(=O)c2ccc(nc2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C23H22ClN5OS/c1-3-23(2,17-5-7-18(24)8-6-17)19-15-31-22(27-19)28-21(30)16-4-9-20(26-14-16)29-12-10-25-11-13-29/h1,4-9,14-15,25H,10-13H2,2H3,(H,27,28,30) BPSVZRAWOOJEII-UHFFFAOYSA-N 662469 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-6- (piperazin-1-yl)nicotinamide::US20240109853, Compound B061::US20240226094, Compound B061::US20250241908, Compound B061::US20250381196, Compound B061 Alpha-protein kinase 1 Homo sapiens 167 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662469 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662469&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407506 496703734 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120288 CC(C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C24H23ClN4OS/c1-3-24(2,18-6-8-19(25)9-7-18)21-16-31-23(27-21)28-22(30)17-4-10-20(11-5-17)29-14-12-26-13-15-29/h1,4-11,16,26H,12-15H2,2H3,(H,27,28,30) ATVVIHZPIRPXCV-UHFFFAOYSA-N 662470 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-4- (piperazin-1-yl)benzamide::US20240109853, Compound B062::US20240226094, Compound B062::US20250241908, Compound B062::US20250381196, Compound B062 Alpha-protein kinase 1 Homo sapiens 12.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662470 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662470&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407468 496703735 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120289 COc1ccc(cc1)C(C)(C)c1csc(NC(=O)c2ccc(OCC(C)O)cc2)n1 InChI=1S/C23H26N2O4S/c1-15(26)13-29-19-9-5-16(6-10-19)21(27)25-22-24-20(14-30-22)23(2,3)17-7-11-18(28-4)12-8-17/h5-12,14-15,26H,13H2,1-4H3,(H,24,25,27) KHHITKRDPQNPNW-UHFFFAOYSA-N 662471 4-(2-hydroxypropoxy)-N-(4- (2-(4-methoxyphenyl)propan- 2-yl)thiazol-2-yl)benzamide::US20240109853, Compound B063::US20240226094, Compound B063::US20250241908, Compound B063::US20250381196, Compound B063 Alpha-protein kinase 1 Homo sapiens 245 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662471 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662471&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407726 496703736 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120290 COc1ccc(F)c(C(=O)Nc2nc(cs2)C(C)(C#C)c2ccc(Cl)cc2)c1F InChI=1S/C21H15ClF2N2O2S/c1-4-21(2,12-5-7-13(22)8-6-12)16-11-29-20(25-16)26-19(27)17-14(23)9-10-15(28-3)18(17)24/h1,5-11H,2-3H3,(H,25,26,27) ILQPPRFXRWRQMJ-UHFFFAOYSA-N 662472 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-2,6- difluoro-3-methoxybenzamide::US20240109853, Compound B064::US20240226094, Compound B064::US20250241908, Compound B064::US20250381196, Compound B064 Alpha-protein kinase 1 Homo sapiens 54.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662472 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662472&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407454 496703737 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120291 CC(C#C)(c1csc(NC(=O)c2ccc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C24H22ClFN4OS/c1-3-24(2,16-4-6-17(25)7-5-16)21-15-32-23(28-21)29-22(31)19-9-8-18(14-20(19)26)30-12-10-27-11-13-30/h1,4-9,14-15,27H,10-13H2,2H3,(H,28,29,31) MLKYVNMKRXEEIO-UHFFFAOYSA-N 662473 US20240109853, Compound B065::N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-2- fluoro-4-(piperazin-1- yl)benzamide::US20240109853, Compound B094::US20240226094, Compound B065::US20250381196, Compound B094 Alpha-protein kinase 1 Homo sapiens 34.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662473 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662473&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407685 496703738 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120292 COc1cc(ccc1N1CCNCC1)C(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Cl)cc1 InChI=1S/C25H25ClN4O2S/c1-4-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(31)17-5-10-20(21(15-17)32-3)30-13-11-27-12-14-30/h1,5-10,15-16,27H,11-14H2,2-3H3,(H,28,29,31) UVKBWHCFWCEXSZ-UHFFFAOYSA-N 662474 US20240109853, Compound B066::N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-3- methoxy-4-(piperazin-1- yl)benzamide::US20240109853, Compound B095::US20240226094, Compound B095::US20250241908, Compound B095::US20250381196, Compound B095 Alpha-protein kinase 1 Homo sapiens 29.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662474 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662474&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407648 496703739 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120293 C[C@@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H23ClN4OS/c1-3-24(2,18-6-8-19(25)9-7-18)21-16-31-23(27-21)28-22(30)17-4-10-20(11-5-17)29-14-12-26-13-15-29/h1,4-11,16,26H,12-15H2,2H3,(H,27,28,30) ATVVIHZPIRPXCV-UHFFFAOYSA-N 662475 US20240109853, Compound B067::N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-4- (piperazin-1-yl)benzamide::US20240109853, Compound B093::US20240226094, Compound B093::US20250241908, Compound B093::US20250381196, Compound B093 Alpha-protein kinase 1 Homo sapiens 90.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662475&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407412 496703740 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120294 C[C@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H23ClN4OS/c1-3-24(2,18-6-8-19(25)9-7-18)21-16-31-23(27-21)28-22(30)17-4-10-20(11-5-17)29-14-12-26-13-15-29/h1,4-11,16,26H,12-15H2,2H3,(H,27,28,30) ATVVIHZPIRPXCV-UHFFFAOYSA-N 662476 US20240109853, Compound B068::N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-4- (piperazin-1-yl)benzamide::US20240109853, Compound B092::US20240226094, Compound B092::US20250381196, Compound B092 Alpha-protein kinase 1 Homo sapiens 530 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662476 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662476&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407527 496703741 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120295 C[C@@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2CO)n1)c1ccc(F)cc1 |r| InChI=1S/C25H25FN4O2S/c1-3-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(32)17-4-10-20(11-5-17)30-13-12-27-14-21(30)15-31/h1,4-11,16,21,27,31H,12-15H2,2H3,(H,28,29,32) OIWGOIUEDIIJFF-UHFFFAOYSA-N 662477 US20240109853, Compound B069::US20240109853, Compound B071::N-[4-[1-(4-fluorophenyl)-1- methyl-prop-2-ynyl]thiazol-2- yl]-4-[2- (hydroxymethyl)piperazin-1- yl]benzamide::US20240226094, Compound B071::US20250241908, Compound B071::US20250381196, Compound B071 Alpha-protein kinase 1 Homo sapiens 20.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662477&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407573 496703742 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120296 C[C@@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2CO)n1)c1ccc(F)cc1 |r| InChI=1S/C25H25FN4O2S/c1-3-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(32)17-4-10-20(11-5-17)30-13-12-27-14-21(30)15-31/h1,4-11,16,21,27,31H,12-15H2,2H3,(H,28,29,32) OIWGOIUEDIIJFF-UHFFFAOYSA-N 662477 US20240109853, Compound B069::US20240109853, Compound B071::N-[4-[1-(4-fluorophenyl)-1- methyl-prop-2-ynyl]thiazol-2- yl]-4-[2- (hydroxymethyl)piperazin-1- yl]benzamide::US20240226094, Compound B071::US20250241908, Compound B071::US20250381196, Compound B071 Alpha-protein kinase 1 Homo sapiens 169 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662477&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407573 496703742 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120297 C[C@@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2CO)n1)c1ccc(F)cc1 |r| InChI=1S/C25H25FN4O2S/c1-3-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(32)17-4-10-20(11-5-17)30-13-12-27-14-21(30)15-31/h1,4-11,16,21,27,31H,12-15H2,2H3,(H,28,29,32) OIWGOIUEDIIJFF-UHFFFAOYSA-N 662477 US20240109853, Compound B069::US20240109853, Compound B071::N-[4-[1-(4-fluorophenyl)-1- methyl-prop-2-ynyl]thiazol-2- yl]-4-[2- (hydroxymethyl)piperazin-1- yl]benzamide::US20240226094, Compound B071::US20250241908, Compound B071::US20250381196, Compound B071 Alpha-protein kinase 1 Homo sapiens 60.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662477 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662477&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407573 496703742 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120298 C#C[C@](C)(c1ccc(F)cc1)c4csc(NC(=O)c3ccc(N2CCNCC2CO)cc3)n4 InChI=1S/C25H25FN4O2S/c1-3-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(32)17-4-10-20(11-5-17)30-13-12-27-14-21(30)15-31/h1,4-11,16,21,27,31H,12-15H2,2H3,(H,28,29,32) OIWGOIUEDIIJFF-UHFFFAOYSA-N 662480 N-[4-[1-(4-fluorophenyl)-1- methyl-prop-2-ynyl]thiazol-2- yl]-4-[2- (hydroxymethyl)piperazin-1- yl]benzamide::US20240109853, Compound B072::US20250381196, Compound B072 Alpha-protein kinase 1 Homo sapiens 260 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662480 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662480&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120299 C[C@](C#C)(c1csc(NC(=O)c2c(F)ccc(N3CCNCC3)c2F)n1)c1ccc(F)cc1 |r| InChI=1S/C24H21F3N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)19-14-33-23(29-19)30-22(32)20-17(26)8-9-18(21(20)27)31-12-10-28-11-13-31/h1,4-9,14,28H,10-13H2,2H3,(H,29,30,32) GWGRMQSQSZUARA-UHFFFAOYSA-N 662481 2,6-difluoro-N-(4-(2-(4- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)-3-(piperazin-1- yl)benzamide::US20240109853, Compound B073::US20240226094, Compound B073::US20250241908, Compound B074::US20250381196, Compound B073 Alpha-protein kinase 1 Homo sapiens 85.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662481 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662481&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407639 496703744 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120300 C[C@@](C#C)(c1csc(NC(=O)c2c(F)ccc(N3CCNCC3)c2F)n1)c1ccc(F)cc1 |r| InChI=1S/C24H21F3N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)19-14-33-23(29-19)30-22(32)20-17(26)8-9-18(21(20)27)31-12-10-28-11-13-31/h1,4-9,14,28H,10-13H2,2H3,(H,29,30,32) GWGRMQSQSZUARA-UHFFFAOYSA-N 662482 2,6-difluoro-N-(4-(2-(4- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)-3-(piperazin-1- yl)benzamide::US20240109853, Compound B074::US20240226094, Compound B074::US20250381196, Compound B074 Alpha-protein kinase 1 Homo sapiens 96.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662482 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662482&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407696 496703745 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120301 C[C@](C#C)(c1csc(NC(=O)c2c(F)ccc(N3CCNCC3)c2F)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H21ClF2N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)19-14-33-23(29-19)30-22(32)20-17(26)8-9-18(21(20)27)31-12-10-28-11-13-31/h1,4-9,14,28H,10-13H2,2H3,(H,29,30,32) SRKUODGOQJCRMM-UHFFFAOYSA-N 662483 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-2,6- difluoro-3-(piperazin-1- yl)benzamide::US20240109853, Compound B075::US20240226094, Compound B075::US20250241908, Compound B075::US20250381196, Compound B075 Alpha-protein kinase 1 Homo sapiens 308 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662483 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662483&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407508 496703746 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120302 C[C@@](C#C)(c1csc(NC(=O)c2c(F)ccc(N3CCNCC3)c2F)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H21ClF2N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)19-14-33-23(29-19)30-22(32)20-17(26)8-9-18(21(20)27)31-12-10-28-11-13-31/h1,4-9,14,28H,10-13H2,2H3,(H,29,30,32) SRKUODGOQJCRMM-UHFFFAOYSA-N 662484 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-2,6- difluoro-3-(piperazin-1- yl)benzamide::US20240109853, Compound B076::US20240226094, Compound B076::US20250241908, Compound B076::US20250381196, Compound B076 Alpha-protein kinase 1 Homo sapiens 85.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662484 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662484&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407586 496703747 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120303 C[C@@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNC(CO)C2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C25H25ClN4O2S/c1-3-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(32)17-4-10-21(11-5-17)30-13-12-27-20(14-30)15-31/h1,4-11,16,20,27,31H,12-15H2,2H3,(H,28,29,32) MJZOZYQXCCNFRN-UHFFFAOYSA-N 662485 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-4-(3- (hydroxymethyl)piperazin-1- yl)benzamide::US20240109853, Compound B077::US20240226094, Compound B077::US20250241908, Compound B077::US20250381196, Compound B077 Alpha-protein kinase 1 Homo sapiens 90.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662485 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662485&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407519 496703748 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120304 C[C@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNC(CO)C2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C25H25ClN4O2S/c1-3-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(32)17-4-10-21(11-5-17)30-13-12-27-20(14-30)15-31/h1,4-11,16,20,27,31H,12-15H2,2H3,(H,28,29,32) MJZOZYQXCCNFRN-UHFFFAOYSA-N 662486 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-y1)-4-(3- (hydroxymethyl)piperazin-1- yl)benzamide::US20240109853, Compound B078::US20240226094, Compound B078::US20250241908, Compound B078::US20250381196, Compound B078 Alpha-protein kinase 1 Homo sapiens 169 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662486 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662486&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407471 496703749 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120305 C[C@@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNC(CO)C2)n1)c1ccc(F)cc1 |r| InChI=1S/C25H25FN4O2S/c1-3-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(32)17-4-10-21(11-5-17)30-13-12-27-20(14-30)15-31/h1,4-11,16,20,27,31H,12-15H2,2H3,(H,28,29,32) QKRPMQVZBSLIPL-UHFFFAOYSA-N 662487 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-4-(3- (hydroxymethyl)piperazin-1- yl)benzamide::US20240109853, Compound B079::US20240226094, Compound B079::US20250241908, Compound B079::US20250381196, Compound B079 Alpha-protein kinase 1 Homo sapiens 174 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662487 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662487&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407845 496703750 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120306 C[C@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNC(CO)C2)n1)c1ccc(F)cc1 |r| InChI=1S/C25H25FN4O2S/c1-3-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(32)17-4-10-21(11-5-17)30-13-12-27-20(14-30)15-31/h1,4-11,16,20,27,31H,12-15H2,2H3,(H,28,29,32) QKRPMQVZBSLIPL-UHFFFAOYSA-N 662488 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-4-(3- (hydroxymethyl)piperazin-1- yl)benzamide::US20240109853, Compound B080::US20240226094, Compound B080::US20250241908, Compound B080::US20250381196, Compound B080 Alpha-protein kinase 1 Homo sapiens 286 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662488 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662488&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407425 496703751 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120307 CC(C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNC(CO)C2)n1)c1ccc(F)cc1 InChI=1S/C25H23F3N4O2S/c1-3-25(2,15-4-6-16(26)7-5-15)21-14-35-24(30-21)31-23(34)22-19(27)10-18(11-20(22)28)32-9-8-29-17(12-32)13-33/h1,4-7,10-11,14,17,29,33H,8-9,12-13H2,2H3,(H,30,31,34) OLACJCDTJGQQEV-UHFFFAOYSA-N 662490 2,6-difluoro-N-(4-(2-(4- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)-4-(3- (hydroxymethyl)piperazin-1- yl)benzamide::US20240109853, Compound B082::US20240226094, Compound B082::US20250241908, Compound B082::US20250381196, Compound B082 Alpha-protein kinase 1 Homo sapiens 25.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662490 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662490&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407370 496703753 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120308 CC(C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNC(CO)C2)n1)c1ccc(Cl)cc1 InChI=1S/C25H23ClF2N4O2S/c1-3-25(2,15-4-6-16(26)7-5-15)21-14-35-24(30-21)31-23(34)22-19(27)10-18(11-20(22)28)32-9-8-29-17(12-32)13-33/h1,4-7,10-11,14,17,29,33H,8-9,12-13H2,2H3,(H,30,31,34) QRTYPPGIHCKVDH-UHFFFAOYSA-N 662491 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-2,6- difluoro-4-(3- (hydroxymethyl)piperazin-1- yl)benzamide::US20240109853, Compound B083::US20240226094, Compound B083::US20250241908, Compound B083::US20250381196, Compound B083 Alpha-protein kinase 1 Homo sapiens 78.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662491 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662491&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407477 496703754 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120309 COc1ccc(cc1)C(C)(C#C)c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNC(CO)C2)n1 InChI=1S/C26H26F2N4O3S/c1-4-26(2,16-5-7-19(35-3)8-6-16)22-15-36-25(30-22)31-24(34)23-20(27)11-18(12-21(23)28)32-10-9-29-17(13-32)14-33/h1,5-8,11-12,15,17,29,33H,9-10,13-14H2,2-3H3,(H,30,31,34) SGEYCAVSQMNUCX-UHFFFAOYSA-N 662492 2,6-difluoro-4-(3- (hydroxymethyl)piperazin-1- yl)-N-(4-(2-(4- methoxyphenyl)but-3-yn-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B084::US20240226094, Compound B084::US20250241908, Compound B084::US20250381196, Compound B084 Alpha-protein kinase 1 Homo sapiens 28.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662492 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662492&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407395 496703755 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120310 C#C[C@](C)(c1ccc(Cl)cc1)c4csc(NC(=O)c3c(F)cc(N2CCC(N)C2)cc3F)n4 InChI=1S/C24H21ClF2N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-13-33-23(29-20)30-22(32)21-18(26)10-17(11-19(21)27)31-9-8-16(28)12-31/h1,4-7,10-11,13,16H,8-9,12,28H2,2H3,(H,29,30,32) WCPSZMXIYFSOIK-UHFFFAOYSA-N 662494 4-(3-aminopyrrolidin-1-y])-N- (4-(2-(4-chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)-2,6- difluorobenzamide::US20240109853, Compound B086::US20250381196, Compound B086 Alpha-protein kinase 1 Homo sapiens 395 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662494&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120311 C#C[C@](C)(c1ccc(Cl)cc1)c4csc(NC(=O)c3c(F)cc(N2CCC(N)C2)cc3F)n4 InChI=1S/C24H21ClF2N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-13-33-23(29-20)30-22(32)21-18(26)10-17(11-19(21)27)31-9-8-16(28)12-31/h1,4-7,10-11,13,16H,8-9,12,28H2,2H3,(H,29,30,32) WCPSZMXIYFSOIK-UHFFFAOYSA-N 662494 4-(3-aminopyrrolidin-1-y])-N- (4-(2-(4-chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)-2,6- difluorobenzamide::US20240109853, Compound B086::US20250381196, Compound B086 Alpha-protein kinase 1 Homo sapiens 286 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662494&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120312 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCC(N)C2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H21ClF2N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-13-33-23(29-20)30-22(32)21-18(26)10-17(11-19(21)27)31-9-8-16(28)12-31/h1,4-7,10-11,13,16H,8-9,12,28H2,2H3,(H,29,30,32) WCPSZMXIYFSOIK-UHFFFAOYSA-N 662495 US20240109853, Compound B087::US20240109853, Compound B088::4-(3-aminopyrrolidin-1-yl)-N- (4-(2-(4-chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)-2,6- difluorobenzamide::US20240226094, Compound B088::US20250381196, Compound B088 Alpha-protein kinase 1 Homo sapiens 38.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662495&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407629 496703757 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120313 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCC(N)C2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H21ClF2N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-13-33-23(29-20)30-22(32)21-18(26)10-17(11-19(21)27)31-9-8-16(28)12-31/h1,4-7,10-11,13,16H,8-9,12,28H2,2H3,(H,29,30,32) WCPSZMXIYFSOIK-UHFFFAOYSA-N 662495 US20240109853, Compound B087::US20240109853, Compound B088::4-(3-aminopyrrolidin-1-yl)-N- (4-(2-(4-chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)-2,6- difluorobenzamide::US20240226094, Compound B088::US20250381196, Compound B088 Alpha-protein kinase 1 Homo sapiens 42.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662495&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407629 496703757 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120314 C[C@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCC(N)C2)n1)c1ccc(F)cc1 |r| InChI=1S/C24H21F3N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-13-33-23(29-20)30-22(32)21-18(26)10-17(11-19(21)27)31-9-8-16(28)12-31/h1,4-7,10-11,13,16H,8-9,12,28H2,2H3,(H,29,30,32) AIWBHAOWGAJELF-UHFFFAOYSA-N 662497 4-(3-aminopyrrolidin-1-yl)- 2,6-difluoro-N-(4-(2-(4- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B089::US20240226094, Compound B089::US20250241908, Compound B089::US20250381196, Compound B089 Alpha-protein kinase 1 Homo sapiens 681 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662497 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662497&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407821 496703758 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120315 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCC(N)C2)n1)c1ccc(F)cc1 |r| InChI=1S/C24H21F3N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-13-33-23(29-20)30-22(32)21-18(26)10-17(11-19(21)27)31-9-8-16(28)12-31/h1,4-7,10-11,13,16H,8-9,12,28H2,2H3,(H,29,30,32) AIWBHAOWGAJELF-UHFFFAOYSA-N 662498 US20240109853, Compound B090::US20240109853, Compound B091::4-(3-aminopyrrolidin-1-yl)- 2,6-difluoro-N-(4-(2-(4- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)benzamide::US20240226094, Compound B091::US20250241908, Compound B091::US20250381196, Compound B091 Alpha-protein kinase 1 Homo sapiens 107 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662498&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407411 496703759 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120316 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCC(N)C2)n1)c1ccc(F)cc1 |r| InChI=1S/C24H21F3N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-13-33-23(29-20)30-22(32)21-18(26)10-17(11-19(21)27)31-9-8-16(28)12-31/h1,4-7,10-11,13,16H,8-9,12,28H2,2H3,(H,29,30,32) AIWBHAOWGAJELF-UHFFFAOYSA-N 662498 US20240109853, Compound B090::US20240109853, Compound B091::4-(3-aminopyrrolidin-1-yl)- 2,6-difluoro-N-(4-(2-(4- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)benzamide::US20240226094, Compound B091::US20250241908, Compound B091::US20250381196, Compound B091 Alpha-protein kinase 1 Homo sapiens 65.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662498 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662498&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407411 496703759 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120317 C[C@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H23ClN4OS/c1-3-24(2,18-6-8-19(25)9-7-18)21-16-31-23(27-21)28-22(30)17-4-10-20(11-5-17)29-14-12-26-13-15-29/h1,4-11,16,26H,12-15H2,2H3,(H,27,28,30) ATVVIHZPIRPXCV-UHFFFAOYSA-N 662476 US20240109853, Compound B068::N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-4- (piperazin-1-yl)benzamide::US20240109853, Compound B092::US20240226094, Compound B092::US20250381196, Compound B092 Alpha-protein kinase 1 Homo sapiens 219 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662476 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662476&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407527 496703741 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120318 C[C@@](C#C)(c1csc(NC(=O)c2ccc(cc2)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H23ClN4OS/c1-3-24(2,18-6-8-19(25)9-7-18)21-16-31-23(27-21)28-22(30)17-4-10-20(11-5-17)29-14-12-26-13-15-29/h1,4-11,16,26H,12-15H2,2H3,(H,27,28,30) ATVVIHZPIRPXCV-UHFFFAOYSA-N 662475 US20240109853, Compound B067::N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-4- (piperazin-1-yl)benzamide::US20240109853, Compound B093::US20240226094, Compound B093::US20250241908, Compound B093::US20250381196, Compound B093 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662475 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662475&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407412 496703740 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120319 CC(C#C)(c1csc(NC(=O)c2ccc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C24H22ClFN4OS/c1-3-24(2,16-4-6-17(25)7-5-16)21-15-32-23(28-21)29-22(31)19-9-8-18(14-20(19)26)30-12-10-27-11-13-30/h1,4-9,14-15,27H,10-13H2,2H3,(H,28,29,31) MLKYVNMKRXEEIO-UHFFFAOYSA-N 662473 US20240109853, Compound B065::N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-2- fluoro-4-(piperazin-1- yl)benzamide::US20240109853, Compound B094::US20240226094, Compound B065::US20250381196, Compound B094 Alpha-protein kinase 1 Homo sapiens 151 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662473 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662473&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407685 496703738 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120320 COc1cc(ccc1N1CCNCC1)C(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Cl)cc1 InChI=1S/C25H25ClN4O2S/c1-4-25(2,18-6-8-19(26)9-7-18)22-16-33-24(28-22)29-23(31)17-5-10-20(21(15-17)32-3)30-13-11-27-12-14-30/h1,5-10,15-16,27H,11-14H2,2-3H3,(H,28,29,31) UVKBWHCFWCEXSZ-UHFFFAOYSA-N 662474 US20240109853, Compound B066::N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2-yl)-3- methoxy-4-(piperazin-1- yl)benzamide::US20240109853, Compound B095::US20240226094, Compound B095::US20250241908, Compound B095::US20250381196, Compound B095 Alpha-protein kinase 1 Homo sapiens 184 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662474 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662474&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407648 496703739 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120321 CC(C#C)(c1csc(NC(=O)c2c(Cl)cc(cc2Cl)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C24H21Cl3N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)20-14-33-23(29-20)30-22(32)21-18(26)12-17(13-19(21)27)31-10-8-28-9-11-31/h1,4-7,12-14,28H,8-11H2,2H3,(H,29,30,32) LQNKPKZAAXYFNP-UHFFFAOYSA-N 662504 2,6-dichloro-N-(4-(2-(4- chlorophenyl)but-3-yn-2- yl)thiazol-2-yl)-4-(piperazin-1- yl)benzamide::US20240109853, Compound B096::US20240226094, Compound B096::US20250241908, Compound B096::US20250381196, Compound B096 Alpha-protein kinase 1 Homo sapiens 312 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662504 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662504&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407575 496703760 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120322 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2CO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C25H23ClF2N4O2S/c1-3-25(2,15-4-6-16(26)7-5-15)21-14-35-24(30-21)31-23(34)22-19(27)10-17(11-20(22)28)32-9-8-29-12-18(32)13-33/h1,4-7,10-11,14,18,29,33H,8-9,12-13H2,2H3,(H,30,31,34) OSVYIUSJBSNYHH-UHFFFAOYSA-N 662505 N-[4-[1-(4-chlorophenyl)-1- methyl-prop-2-ynyl]thiazol-2- yl]-2,6-difluoro-4-[2- (hydroxymethyl)piperazin-1- yl]benzamide::US20240109853, Compound B097::US20240226094, Compound B097::US20250241908, Compound B097::US20250381196, Compound B097 Alpha-protein kinase 1 Homo sapiens 119 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662505 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662505&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407382 496703761 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120323 C[C@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2CO)n1)c1ccc(Cl)cc1 |r| InChI=1S/C25H23ClF2N4O2S/c1-3-25(2,15-4-6-16(26)7-5-15)21-14-35-24(30-21)31-23(34)22-19(27)10-17(11-20(22)28)32-9-8-29-12-18(32)13-33/h1,4-7,10-11,14,18,29,33H,8-9,12-13H2,2H3,(H,30,31,34) OSVYIUSJBSNYHH-UHFFFAOYSA-N 662506 N-[4-[1-(4-chlorophenyl)-1- methyl-prop-2-ynyl]thiazol-2- yl]-2,6-difluoro-4-[2- (hydroxymethyl)piperazin-1- yl]benzamide::US20240109853, Compound B098::US20240226094, Compound B098::US20250241908, Compound B098::US20250381196, Compound B098 Alpha-protein kinase 1 Homo sapiens 20.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662506 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662506&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407744 496703762 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120324 CC(C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2CO)n1)c1ccc(F)cc1 InChI=1S/C25H23F3N4O2S/c1-3-25(2,15-4-6-16(26)7-5-15)21-14-35-24(30-21)31-23(34)22-19(27)10-17(11-20(22)28)32-9-8-29-12-18(32)13-33/h1,4-7,10-11,14,18,29,33H,8-9,12-13H2,2H3,(H,30,31,34) CUEFUKYQFIFQKD-UHFFFAOYSA-N 662507 2,6-difluoro-N-[4-[1-(4- fluorophenyl)-1-methyl-prop- 2-ynyl]thiazol-2-yl]-4-[2- (hydroxymethyl)piperazin-1- yl]benzamide::US20240109853, Compound B099::US20240226094, Compound B099::US20250381196, Compound B099 Alpha-protein kinase 1 Homo sapiens 30.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662507 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662507&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407747 496703763 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120325 C#CC(C)(c1ccc(OC)cc1)c4csc(NC(=O)c3c(F)cc(N2CCNCC2CO)cc3F)n4 InChI=1S/C26H26F2N4O3S/c1-4-26(2,16-5-7-19(35-3)8-6-16)22-15-36-25(30-22)31-24(34)23-20(27)11-17(12-21(23)28)32-10-9-29-13-18(32)14-33/h1,5-8,11-12,15,18,29,33H,9-10,13-14H2,2-3H3,(H,30,31,34) DZTMFMAJTQKOLK-UHFFFAOYSA-N 761440 2,6-difluoro-4-[2- (hydroxymethyl) piperazin-1-yl]- N-[4-[1-(4- methoxyphenyl)- 1-methyl-prop- 2-ynyl]thiazol- 2-yl]benzamide::US20250241908, Compound B100::US20250381196, Compound B100 Alpha-protein kinase 1 Homo sapiens 21.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=761440 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=761440&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407373 520671707 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120326 CCC1CNCCN1c1cc(F)c(C(=O)Nc2nc(cs2)C(C)(C#C)c2ccc(Cl)cc2)c(F)c1 InChI=1S/C26H25ClF2N4OS/c1-4-18-14-30-10-11-33(18)19-12-20(28)23(21(29)13-19)24(34)32-25-31-22(15-35-25)26(3,5-2)16-6-8-17(27)9-7-16/h2,6-9,12-13,15,18,30H,4,10-11,14H2,1,3H3,(H,31,32,34) MBOPCMUWUSAJIC-UHFFFAOYSA-N 662509 N-(4-(2-(4- chlorophenyl)but-3-yn-2- yl)thiazol-2-yl)-4-(2- ethylpiperazin-1-yl)-2,6- difluorobenzamide::US20240109853, Compound B101::US20250241908, Compound B101::US20250381196, Compound B101 Alpha-protein kinase 1 Homo sapiens 70.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662509 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662509&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407731 496703765 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120327 Cn1ncc(c1N)-c1cc(F)c(C(=O)Nc2nc(cs2)C(C)(C#C)c2ccc(F)cc2)c(F)c1 InChI=1S/C24H18F3N5OS/c1-4-24(2,14-5-7-15(25)8-6-14)19-12-34-23(30-19)31-22(33)20-17(26)9-13(10-18(20)27)16-11-29-32(3)21(16)28/h1,5-12H,28H2,2-3H3,(H,30,31,33) BNCGXAAYJPLQRJ-UHFFFAOYSA-N 662510 4-(5-amino-1-methyl-1H- pyrazol-4-yl)-2,6-difluoro-N- (4-(2-(4-fluorophenyl)but-3- yn-2-yl)thiazol-2- yl)benzamide::US20240109853, Compound B102::US20240226094, Compound B102::US20250241908, Compound B102::US20250381196, Compound B102 Alpha-protein kinase 1 Homo sapiens 1269 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662510 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662510&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407365 496703766 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120328 Cn1[nH]cc(-c2cc(F)c(C(=O)Nc3nc(cs3)C(C)(C#C)c3ccc(F)cc3)c(F)c2)c1=O InChI=1S/C24H17F3N4O2S/c1-4-24(2,14-5-7-15(25)8-6-14)19-12-34-23(29-19)30-21(32)20-17(26)9-13(10-18(20)27)16-11-28-31(3)22(16)33/h1,5-12,28H,2-3H3,(H,29,30,32) JZNZBIABBUPXTI-UHFFFAOYSA-N 662511 2,6-difluoro-N-(4-(2-(4- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)-4-(2-methyl-3- oxo-2,3-dihydro-1H-pyrazol- 4-yl)benzamide::US20240109853, Compound B103::US20240226094, Compound B103::US20250241908, Compound B103::US20250381196, Compound B103 Alpha-protein kinase 1 Homo sapiens 5139 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662511 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662511&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407683 496703767 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120329 CC(C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)-c2cnc(CN)cn2)n1)c1ccc(F)cc1 InChI=1S/C25H18F3N5OS/c1-3-25(2,15-4-6-16(26)7-5-15)21-13-35-24(32-21)33-23(34)22-18(27)8-14(9-19(22)28)20-12-30-17(10-29)11-31-20/h1,4-9,11-13H,10,29H2,2H3,(H,32,33,34) DJIZWTGAFHIKSS-UHFFFAOYSA-N 662512 4-(5-(aminomethyl)pyrazin-2- yl)-2,6-difluoro-N-(4-(2-(4- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)benzamide::US20240109853, Compound B104::US20240226094, Compound B104::US20250241908, Compound B104::US20250381196, Compound B104 Alpha-protein kinase 1 Homo sapiens 1474 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662512 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662512&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407417 496703768 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120330 CC(C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C24H21ClF2N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)20-14-33-23(29-20)30-22(32)21-18(26)12-17(13-19(21)27)31-10-8-28-9-11-31/h1,4-7,12-14,28H,8-11H2,2H3,(H,29,30,32) ANRFSQHHAOCNIN-UHFFFAOYSA-N 662513 N-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C001::US20240226094, Compound C001::US20250241908, Compound C001::US20250381196, Compound C001 Alpha-protein kinase 1 Homo sapiens 3.70 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662513 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662513&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407646 496703769 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120331 CC(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccccc1 InChI=1S/C22H22F2N4OS/c1-14(15-5-3-2-4-6-15)19-13-30-22(26-19)27-21(29)20-17(23)11-16(12-18(20)24)28-9-7-25-8-10-28/h2-6,11-14,25H,7-10H2,1H3,(H,26,27,29) VIHOXNKPWWCMMI-UHFFFAOYSA-N 662514 2,6-difluoro-N-(4-(1- phenylethyl)thiazol-2- yl)-4-(piperazin-1- yl)benzamide::US20240109853, Compound C002::US20240226094, Compound C002::US20250241908, Compound C002::US20250381196, Compound C002 Alpha-protein kinase 1 Homo sapiens 47.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662514 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662514&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407652 496703770 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120332 CC(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C22H21ClF2N4OS/c1-13(14-2-4-15(23)5-3-14)19-12-31-22(27-19)28-21(30)20-17(24)10-16(11-18(20)25)29-8-6-26-7-9-29/h2-5,10-13,26H,6-9H2,1H3,(H,27,28,30) XUULFLXWICKUQF-UHFFFAOYSA-N 662515 N-(4-(1-(4- chlorophenyl)ethyl)thi- azol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240109853, Compound C003::US20240226094, Compound C003::US20250241908, Compound C003::US20250381196, Compound C003 Alpha-protein kinase 1 Homo sapiens 11.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662515 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662515&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407507 496703771 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120333 COCC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccccc1 InChI=1S/C24H26F2N4O2S/c1-24(15-32-2,16-6-4-3-5-7-16)20-14-33-23(28-20)29-22(31)21-18(25)12-17(13-19(21)26)30-10-8-27-9-11-30/h3-7,12-14,27H,8-11,15H2,1-2H3,(H,28,29,31) BAZBRTKNHCXOFM-UHFFFAOYSA-N 662516 2,6-difluoro-N-(4-(1- methoxy-2- phenylpropan-2- yl)thiazol-2-yl)-4- (piperazin-1- yl)benzamide::US20240109853, Compound C004::US20240226094, Compound C004::US20250241908, Compound C004::US20250381196, Compound C004 Alpha-protein kinase 1 Homo sapiens 22.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662516 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662516&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407374 496703772 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120334 CC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(F)cc1 InChI=1S/C23H23F3N4OS/c1-23(2,14-3-5-15(24)6-4-14)19-13-32-22(28-19)29-21(31)20-17(25)11-16(12-18(20)26)30-9-7-27-8-10-30/h3-6,11-13,27H,7-10H2,1-2H3,(H,28,29,31) NBHSGCZUAZTHGE-UHFFFAOYSA-N 662517 2,6-difluoro-N-(4-(2- (4- fluorophenyl)propan- 2-yl)thiazol-2-yl)-4- (piperazin-1- yl)benzamide::US20240109853, Compound C005::US20240226094, Compound C005::US20250241908, Compound C005::US20250381196, Compound C005 Alpha-protein kinase 1 Homo sapiens 6.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662517 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662517&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407512 496703773 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120335 Fc1cc(cc(F)c1C(=O)Nc1nc(cs1)C1(CCCC1)c1ccc(Br)cc1)N1CCNCC1 InChI=1S/C25H25BrF2N4OS/c26-17-5-3-16(4-6-17)25(7-1-2-8-25)21-15-34-24(30-21)31-23(33)22-19(27)13-18(14-20(22)28)32-11-9-29-10-12-32/h3-6,13-15,29H,1-2,7-12H2,(H,30,31,33) WSNAGWONSLNPGR-UHFFFAOYSA-N 662518 US20240109853, Compound C006::US20240109853, Compound C026::N-(4-(1-(4- bromophenyl)cyclopen- tyl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240226094, Compound C026::US20250381196, Compound C026 Alpha-protein kinase 1 Homo sapiens 43.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662518 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662518&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407808 496703774 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120336 C[C@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H21ClF2N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)20-14-33-23(29-20)30-22(32)21-18(26)12-17(13-19(21)27)31-10-8-28-9-11-31/h1,4-7,12-14,28H,8-11H2,2H3,(H,29,30,32) ANRFSQHHAOCNIN-UHFFFAOYSA-N 662519 (R)-N-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C007::US20240226094, Compound C007::US20250241908, Compound C007::US20250381196, Compound C007 Alpha-protein kinase 1 Homo sapiens 10.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662519 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662519&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407446 496703775 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120337 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H21ClF2N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)20-14-33-23(29-20)30-22(32)21-18(26)12-17(13-19(21)27)31-10-8-28-9-11-31/h1,4-7,12-14,28H,8-11H2,2H3,(H,29,30,32) ANRFSQHHAOCNIN-UHFFFAOYSA-N 662520 (S)-N-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C008::US20240226094, Compound C008::US20250241908, Compound C008::US20250381196, Compound C008 Alpha-protein kinase 1 Homo sapiens 5.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662520 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662520&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407492 496703776 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120338 CN1CCN(CC1)c1cc(F)c(C(=O)Nc2nc(cs2)[C@](C)(C#C)c2ccc(Cl)cc2)c(F)c1 |r| InChI=1S/C25H23ClF2N4OS/c1-4-25(2,16-5-7-17(26)8-6-16)21-15-34-24(29-21)30-23(33)22-19(27)13-18(14-20(22)28)32-11-9-31(3)10-12-32/h1,5-8,13-15H,9-12H2,2-3H3,(H,29,30,33) MODDWYBHGYHQPD-UHFFFAOYSA-N 662522 (R)-N-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4-(4- methylpiperazin-1- yl)benzamide::US20240109853, Compound C010::US20240226094, Compound C010::US20250241908, Compound C010::US20250381196, Compound C010 Alpha-protein kinase 1 Homo sapiens 7.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662522&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407655 496703778 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120339 CN1CCN(CC1)c1cc(F)c(C(=O)Nc2nc(cs2)[C@](C)(C#C)c2ccc(Cl)cc2)c(F)c1 |r| InChI=1S/C25H23ClF2N4OS/c1-4-25(2,16-5-7-17(26)8-6-16)21-15-34-24(29-21)30-23(33)22-19(27)13-18(14-20(22)28)32-11-9-31(3)10-12-32/h1,5-8,13-15H,9-12H2,2-3H3,(H,29,30,33) MODDWYBHGYHQPD-UHFFFAOYSA-N 662522 (R)-N-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4-(4- methylpiperazin-1- yl)benzamide::US20240109853, Compound C010::US20240226094, Compound C010::US20250241908, Compound C010::US20250381196, Compound C010 Alpha-protein kinase 1 Homo sapiens 56.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662522 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662522&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407655 496703778 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120340 CN1CCN(CC1)c1cc(F)c(C(=O)Nc2nc(cs2)[C@@](C)(C#C)c2ccc(Cl)cc2)c(F)c1 |r| InChI=1S/C25H23ClF2N4OS/c1-4-25(2,16-5-7-17(26)8-6-16)21-15-34-24(29-21)30-23(33)22-19(27)13-18(14-20(22)28)32-11-9-31(3)10-12-32/h1,5-8,13-15H,9-12H2,2-3H3,(H,29,30,33) MODDWYBHGYHQPD-UHFFFAOYSA-N 662523 (S)-N-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4-(4- methylpiperazin-1- yl)benzamide::US20240109853, Compound C011::US20240226094, Compound C011::US20250241908, Compound C011::US20250381196, Compound C011 Alpha-protein kinase 1 Homo sapiens 18.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662523 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662523&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407474 496703779 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120341 CCOCC(C)(c1ccccc1)c4csc(NC(=O)c3c(F)cc(N2CCNCC2)cc3F)n4 InChI=1S/C25H28F2N4O2S/c1-3-33-16-25(2,17-7-5-4-6-8-17)21-15-34-24(29-21)30-23(32)22-19(26)13-18(14-20(22)27)31-11-9-28-10-12-31/h4-8,13-15,28H,3,9-12,16H2,1-2H3,(H,29,30,32) RUBHVTBVIQGKRT-UHFFFAOYSA-N 662542 N-(4-(1-ethoxy-2- phenylpropan-2- yl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240109853, Compound C031::US20250381196, Compound C031 Alpha-protein kinase 1 Homo sapiens 78.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662542&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120342 COCC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCN(C)CC2)n1)c1ccccc1 InChI=1S/C25H28F2N4O2S/c1-25(16-33-3,17-7-5-4-6-8-17)21-15-34-24(28-21)29-23(32)22-19(26)13-18(14-20(22)27)31-11-9-30(2)10-12-31/h4-8,13-15H,9-12,16H2,1-3H3,(H,28,29,32) KNAKUIWYDUWJAF-UHFFFAOYSA-N 662525 US20240109853, Compound C013::US20240109853, Compound C032::N-(4-(1-ethoxy-2- phenylpropan-2- yl)thiazol-2-yl)-2,6- difluoro-4-(4- methylpiperazin-1- yl)benzamide::US20240226094, Compound C013::US20250381196, Compound C032 Alpha-protein kinase 1 Homo sapiens 91.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662525 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662525&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407789 496703781 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120343 COCC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C24H25BrF2N4O2S/c1-24(14-33-2,15-3-5-16(25)6-4-15)20-13-34-23(29-20)30-22(32)21-18(26)11-17(12-19(21)27)31-9-7-28-8-10-31/h3-6,11-13,28H,7-10,14H2,1-2H3,(H,29,30,32) PVIRDZUJCCQSKY-UHFFFAOYSA-N 662526 US20240109853, Compound C014::N-(4-(2-(4- bromophenyl)-1- methoxypropan-2- yl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240109853, Compound C027::US20240226094, Compound C027::US20250241908, Compound C027::US20250381196, Compound C027 Alpha-protein kinase 1 Homo sapiens 13.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662526 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662526&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407827 496703782 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120344 CN1CCN(CC1)c1cc(F)c(C(=O)Nc2nc(cs2)C2(CCCC2)c2ccc(Br)cc2)c(F)c1 InChI=1S/C26H27BrF2N4OS/c1-32-10-12-33(13-11-32)19-14-20(28)23(21(29)15-19)24(34)31-25-30-22(16-35-25)26(8-2-3-9-26)17-4-6-18(27)7-5-17/h4-7,14-16H,2-3,8-13H2,1H3,(H,30,31,34) ZENDKNWZNNTGMS-UHFFFAOYSA-N 662527 US20240109853, Compound C015::N-(4-(1-(4- bromophenyl)cyclopen- tyl)thiazol-2-yl)-2,6- difluoro-4-(4- methylpiperazin-1- yl)benzamide::US20240109853, Compound C030::US20240226094, Compound C015::US20250241908, Compound C030::US20250381196, Compound C030 Alpha-protein kinase 1 Homo sapiens 266 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662527&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407749 496703783 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120345 COCC(C)(c1ccc(Cl)cc1)c4csc(NC(=O)c3c(F)cc(N2CCNCC2)cc3F)n4 InChI=1S/C24H25ClF2N4O2S/c1-24(14-33-2,15-3-5-16(25)6-4-15)20-13-34-23(29-20)30-22(32)21-18(26)11-17(12-19(21)27)31-9-7-28-8-10-31/h3-6,11-13,28H,7-10,14H2,1-2H3,(H,29,30,32) IEPJRSOJGFFOHQ-UHFFFAOYSA-N 761472 N-(4-(2-(4- chlorophenyl)- 1- methoxypropan- 2-yl)thiazol-2- yl)-2,6- difluoro-4- (piperazin-1-::US20250241908, Compound C029::US20250381196, Compound C029 Alpha-protein kinase 1 Homo sapiens 16.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=761472 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=761472&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407603 520671739 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120346 COC[C@@](C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccccc1 |r| InChI=1S/C24H26F2N4O2S/c1-24(15-32-2,16-6-4-3-5-7-16)20-14-33-23(28-20)29-22(31)21-18(25)12-17(13-19(21)26)30-10-8-27-9-11-30/h3-7,12-14,27H,8-11,15H2,1-2H3,(H,28,29,31) BAZBRTKNHCXOFM-UHFFFAOYSA-N 662529 (R)-2,6-difluoro-N-(4- (1-methoxy-2- phenylpropan-2- yl)thiazol-2-yl)-4- (piperazin-1- yl)benzamide::US20240109853, Compound C017::US20240226094, Compound C017::US20250241908, Compound C017::US20250381196, Compound C017 Alpha-protein kinase 1 Homo sapiens 67.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662529 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662529&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407861 496703785 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120347 COC[C@](C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccccc1 |r| InChI=1S/C24H26F2N4O2S/c1-24(15-32-2,16-6-4-3-5-7-16)20-14-33-23(28-20)29-22(31)21-18(25)12-17(13-19(21)26)30-10-8-27-9-11-30/h3-7,12-14,27H,8-11,15H2,1-2H3,(H,28,29,31) BAZBRTKNHCXOFM-UHFFFAOYSA-N 662530 (S)-2,6-difluoro-N-(4- (1-methoxy-2- phenylpropan-2- yl)thiazol-2-yl)-4- (piperazin-1- yl)benzamide::US20240109853, Compound C018::US20240226094, Compound C018::US20250241908, Compound C018::US20250381196, Compound C018 Alpha-protein kinase 1 Homo sapiens 36.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662530 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662530&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407406 496703786 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120348 C#C[C@@](C)(c1ccc(Cl)cc1)c4nc(NC(=O)c3c(F)cc(N2CCNCC2)cc3F)sc4Cl InChI=1S/C24H20Cl2F2N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-21(26)34-23(30-20)31-22(33)19-17(27)12-16(13-18(19)28)32-10-8-29-9-11-32/h1,4-7,12-13,29H,8-11H2,2H3,(H,30,31,33) FSVCKSNEGJPVJZ-UHFFFAOYSA-N 662561 N-(5-chloro-4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C050::US20250381196, Compound C020 Alpha-protein kinase 1 Homo sapiens 88.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662561 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662561&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120349 COCC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(OC)cc1 InChI=1S/C25H28F2N4O3S/c1-25(15-33-2,16-4-6-18(34-3)7-5-16)21-14-35-24(29-21)30-23(32)22-19(26)12-17(13-20(22)27)31-10-8-28-9-11-31/h4-7,12-14,28H,8-11,15H2,1-3H3,(H,29,30,32) RBQMMYIZIJIXJW-UHFFFAOYSA-N 662532 US20240109853, Compound C021::2,6-difluoro-N-(4-(1- methoxy-2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-4- (piperazin-1- yl)benzamide::US20240109853, Compound C028::US20240226094, Compound C028::US20250381196, Compound C028 Alpha-protein kinase 1 Homo sapiens 44.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662532 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662532&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407809 496703788 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120350 C[C@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCN(CCO)CC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C26H25ClF2N4O2S/c1-3-26(2,17-4-6-18(27)7-5-17)22-16-36-25(30-22)31-24(35)23-20(28)14-19(15-21(23)29)33-10-8-32(9-11-33)12-13-34/h1,4-7,14-16,34H,8-13H2,2H3,(H,30,31,35) WONWOMGIRSFQRL-UHFFFAOYSA-N 662533 (R)-N-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4-(4-(2- hydroxyethyl)piperazin- 1-yl)benzamide::US20240109853, Compound C022::US20240226094, Compound C022::US20250241908, Compound C022::US20250381196, Compound C022 Alpha-protein kinase 1 Homo sapiens 188 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662533 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662533&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407674 496703789 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120351 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCN(CCO)CC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C26H25ClF2N4O2S/c1-3-26(2,17-4-6-18(27)7-5-17)22-16-36-25(30-22)31-24(35)23-20(28)14-19(15-21(23)29)33-10-8-32(9-11-33)12-13-34/h1,4-7,14-16,34H,8-13H2,2H3,(H,30,31,35) WONWOMGIRSFQRL-UHFFFAOYSA-N 662534 (S)-N-(4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4-(4-(2- hydroxyethyl)piperazin- 1-yl)benzamide::US20240109853, Compound C023::US20240226094, Compound C023::US20250241908, Compound C023::US20250381196, Compound C023 Alpha-protein kinase 1 Homo sapiens 60.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662534 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662534&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407505 496703790 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120352 COC[C@@](C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H25ClF2N4O2S/c1-24(14-33-2,15-3-5-16(25)6-4-15)20-13-34-23(29-20)30-22(32)21-18(26)11-17(12-19(21)27)31-9-7-28-8-10-31/h3-6,11-13,28H,7-10,14H2,1-2H3,(H,29,30,32) IEPJRSOJGFFOHQ-UHFFFAOYSA-N 662535 (R)-N-(4-(2-(4- chlorophenyl)-1- methoxypropan-2- yl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240109853, Compound C024::US20240226094, Compound C024::US20250241908, Compound C024::US20250381196, Compound C024 Alpha-protein kinase 1 Homo sapiens 130 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662535 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662535&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407790 496703791 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120353 COC[C@](C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 |r| InChI=1S/C24H25ClF2N4O2S/c1-24(14-33-2,15-3-5-16(25)6-4-15)20-13-34-23(29-20)30-22(32)21-18(26)11-17(12-19(21)27)31-9-7-28-8-10-31/h3-6,11-13,28H,7-10,14H2,1-2H3,(H,29,30,32) IEPJRSOJGFFOHQ-UHFFFAOYSA-N 662536 (S)-N-(4-(2-(4- chlorophenyl)-1- methoxypropan-2- yl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240109853, Compound C025::US20240226094, Compound C025::US20250241908, Compound C025::US20250381196, Compound C025 Alpha-protein kinase 1 Homo sapiens 8.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662536 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662536&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407384 496703792 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120354 Fc1cc(cc(F)c1C(=O)Nc1nc(cs1)C1(CCCC1)c1ccc(Br)cc1)N1CCNCC1 InChI=1S/C25H25BrF2N4OS/c26-17-5-3-16(4-6-17)25(7-1-2-8-25)21-15-34-24(30-21)31-23(33)22-19(27)13-18(14-20(22)28)32-11-9-29-10-12-32/h3-6,13-15,29H,1-2,7-12H2,(H,30,31,33) WSNAGWONSLNPGR-UHFFFAOYSA-N 662518 US20240109853, Compound C006::US20240109853, Compound C026::N-(4-(1-(4- bromophenyl)cyclopen- tyl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240226094, Compound C026::US20250381196, Compound C026 Alpha-protein kinase 1 Homo sapiens 437 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662518 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662518&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407808 496703774 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120355 COCC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Br)cc1 InChI=1S/C24H25BrF2N4O2S/c1-24(14-33-2,15-3-5-16(25)6-4-15)20-13-34-23(29-20)30-22(32)21-18(26)11-17(12-19(21)27)31-9-7-28-8-10-31/h3-6,11-13,28H,7-10,14H2,1-2H3,(H,29,30,32) PVIRDZUJCCQSKY-UHFFFAOYSA-N 662526 US20240109853, Compound C014::N-(4-(2-(4- bromophenyl)-1- methoxypropan-2- yl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240109853, Compound C027::US20240226094, Compound C027::US20250241908, Compound C027::US20250381196, Compound C027 Alpha-protein kinase 1 Homo sapiens 100.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662526 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662526&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407827 496703782 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120356 COCC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(OC)cc1 InChI=1S/C25H28F2N4O3S/c1-25(15-33-2,16-4-6-18(34-3)7-5-16)21-14-35-24(29-21)30-23(32)22-19(26)12-17(13-20(22)27)31-10-8-28-9-11-31/h4-7,12-14,28H,8-11,15H2,1-3H3,(H,29,30,32) RBQMMYIZIJIXJW-UHFFFAOYSA-N 662532 US20240109853, Compound C021::2,6-difluoro-N-(4-(1- methoxy-2-(4- methoxyphenyl)propan- 2-yl)thiazol-2-yl)-4- (piperazin-1- yl)benzamide::US20240109853, Compound C028::US20240226094, Compound C028::US20250381196, Compound C028 Alpha-protein kinase 1 Homo sapiens 288 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662532 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662532&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407809 496703788 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120357 COCC(C)(c1ccc(Cl)cc1)c4csc(NC(=O)c3c(F)cc(N2CCNCC2)cc3F)n4 InChI=1S/C24H25ClF2N4O2S/c1-24(14-33-2,15-3-5-16(25)6-4-15)20-13-34-23(29-20)30-22(32)21-18(26)11-17(12-19(21)27)31-9-7-28-8-10-31/h3-6,11-13,28H,7-10,14H2,1-2H3,(H,29,30,32) IEPJRSOJGFFOHQ-UHFFFAOYSA-N 761472 N-(4-(2-(4- chlorophenyl)- 1- methoxypropan- 2-yl)thiazol-2- yl)-2,6- difluoro-4- (piperazin-1-::US20250241908, Compound C029::US20250381196, Compound C029 Alpha-protein kinase 1 Homo sapiens 128 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=761472 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=761472&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407603 520671739 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120358 CN1CCN(CC1)c1cc(F)c(C(=O)Nc2nc(cs2)C2(CCCC2)c2ccc(Br)cc2)c(F)c1 InChI=1S/C26H27BrF2N4OS/c1-32-10-12-33(13-11-32)19-14-20(28)23(21(29)15-19)24(34)31-25-30-22(16-35-25)26(8-2-3-9-26)17-4-6-18(27)7-5-17/h4-7,14-16H,2-3,8-13H2,1H3,(H,30,31,34) ZENDKNWZNNTGMS-UHFFFAOYSA-N 662527 US20240109853, Compound C015::N-(4-(1-(4- bromophenyl)cyclopen- tyl)thiazol-2-yl)-2,6- difluoro-4-(4- methylpiperazin-1- yl)benzamide::US20240109853, Compound C030::US20240226094, Compound C015::US20250241908, Compound C030::US20250381196, Compound C030 Alpha-protein kinase 1 Homo sapiens 1770 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662527 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662527&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407749 496703783 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120359 CCOCC(C)(c1ccccc1)c4csc(NC(=O)c3c(F)cc(N2CCNCC2)cc3F)n4 InChI=1S/C25H28F2N4O2S/c1-3-33-16-25(2,17-7-5-4-6-8-17)21-15-34-24(29-21)30-23(32)22-19(26)13-18(14-20(22)27)31-11-9-28-10-12-31/h4-8,13-15,28H,3,9-12,16H2,1-2H3,(H,29,30,32) RUBHVTBVIQGKRT-UHFFFAOYSA-N 662542 N-(4-(1-ethoxy-2- phenylpropan-2- yl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240109853, Compound C031::US20250381196, Compound C031 Alpha-protein kinase 1 Homo sapiens 642 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662542 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662542&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120360 COCC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCN(C)CC2)n1)c1ccccc1 InChI=1S/C25H28F2N4O2S/c1-25(16-33-3,17-7-5-4-6-8-17)21-15-34-24(28-21)29-23(32)22-19(26)13-18(14-20(22)27)31-11-9-30(2)10-12-31/h4-8,13-15H,9-12,16H2,1-3H3,(H,28,29,32) KNAKUIWYDUWJAF-UHFFFAOYSA-N 662525 US20240109853, Compound C013::US20240109853, Compound C032::N-(4-(1-ethoxy-2- phenylpropan-2- yl)thiazol-2-yl)-2,6- difluoro-4-(4- methylpiperazin-1- yl)benzamide::US20240226094, Compound C013::US20250381196, Compound C032 Alpha-protein kinase 1 Homo sapiens 593 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662525 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662525&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407789 496703781 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120361 CC(C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(OC(F)F)cc1 InChI=1S/C25H22F4N4O2S/c1-3-25(2,15-4-6-17(7-5-15)35-23(28)29)20-14-36-24(31-20)32-22(34)21-18(26)12-16(13-19(21)27)33-10-8-30-9-11-33/h1,4-7,12-14,23,30H,8-11H2,2H3,(H,31,32,34) JKGSBZVIMVUEMS-UHFFFAOYSA-N 662544 N-(4-(2-(4- (difluoromethoxy)phe- nyl)but-3-yn-2- yl)thiazol-2-yl)-2,6- difluoro-4-(piperazin- 1-yl)benzamide::US20240109853, Compound C033::US20250241908, Compound C033::US20250381196, Compound C033 Alpha-protein kinase 1 Homo sapiens 73.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662544 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662544&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407721 496703793 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120362 C[C@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(F)cc1 |r| InChI=1S/C24H21F3N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)20-14-33-23(29-20)30-22(32)21-18(26)12-17(13-19(21)27)31-10-8-28-9-11-31/h1,4-7,12-14,28H,8-11H2,2H3,(H,29,30,32) GCHKYKTYBGOZEG-UHFFFAOYSA-N 662545 2,6-difluoro-N-(4-(2- (4-fluorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 4-(piperazin-1- yl)benzamide::US20240109853, Compound C034::US20240226094, Compound C034::US20250241908, Compound C034::US20250381196, Compound C034 Alpha-protein kinase 1 Homo sapiens 40.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662545 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662545&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407479 496703794 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120363 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(F)cc1 |r| InChI=1S/C24H21F3N4OS/c1-3-24(2,15-4-6-16(25)7-5-15)20-14-33-23(29-20)30-22(32)21-18(26)12-17(13-19(21)27)31-10-8-28-9-11-31/h1,4-7,12-14,28H,8-11H2,2H3,(H,29,30,32) GCHKYKTYBGOZEG-UHFFFAOYSA-N 662546 2,6-difluoro-N-(4-(2- (4-fluorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 4-(piperazin-1- yl)benzamide::US20240109853, Compound C035::US20240226094, Compound C035::US20250241908, Compound C035::US20250381196, Compound C035 Alpha-protein kinase 1 Homo sapiens 19.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662546 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662546&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407433 496703795 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120364 COc1ccc(cc1)[C@](C)(C#C)c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1 |r| InChI=1S/C25H24F2N4O2S/c1-4-25(2,16-5-7-18(33-3)8-6-16)21-15-34-24(29-21)30-23(32)22-19(26)13-17(14-20(22)27)31-11-9-28-10-12-31/h1,5-8,13-15,28H,9-12H2,2-3H3,(H,29,30,32) NWVLNCVDYNKJJY-UHFFFAOYSA-N 662547 US20240109853, Compound C036::2,6-difluoro-N-[4-[1- (4-methoxyphenyl)-1- methyl-prop-2- ynyl]thiazol-2-yl]-4- piperazin-1-yl- benzamide::US20240109853, Compound C048::US20240226094, Compound C048::US20250381196, Compound C048 Alpha-protein kinase 1 Homo sapiens 67.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662547&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407697 496703796 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120365 C[C@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)c(F)c1 |r| InChI=1S/C24H20ClF3N4OS/c1-3-24(2,14-4-5-16(25)17(26)10-14)20-13-34-23(30-20)31-22(33)21-18(27)11-15(12-19(21)28)32-8-6-29-7-9-32/h1,4-5,10-13,29H,6-9H2,2H3,(H,30,31,33) VWSGCXVHOOCLFY-UHFFFAOYSA-N 662548 N-(4-(2-(4-chloro-3- fluorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C037::US20240226094, Compound C037::US20250241908, Compound C037::US20250381196, Compound C037 Alpha-protein kinase 1 Homo sapiens 151 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662548 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662548&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407628 496703797 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120366 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)c(F)c1 |r| InChI=1S/C24H20ClF3N4OS/c1-3-24(2,14-4-5-16(25)17(26)10-14)20-13-34-23(30-20)31-22(33)21-18(27)11-15(12-19(21)28)32-8-6-29-7-9-32/h1,4-5,10-13,29H,6-9H2,2H3,(H,30,31,33) VWSGCXVHOOCLFY-UHFFFAOYSA-N 662549 N-(4-(2-(4-chloro-3- fluorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C038::US20240226094, Compound C038::US20250241908, Compound C038::US20250381196, Compound C038 Alpha-protein kinase 1 Homo sapiens 17.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662549 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662549&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407366 496703798 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120367 CC#CC(C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C25H23ClF2N4OS/c1-3-8-25(2,16-4-6-17(26)7-5-16)21-15-34-24(30-21)31-23(33)22-19(27)13-18(14-20(22)28)32-11-9-29-10-12-32/h4-7,13-15,29H,9-12H2,1-2H3,(H,30,31,33) JHKBTVWCNWGNIH-UHFFFAOYSA-N 662550 N-(4-(2-(4- chlorophenyl)pent-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C039::US20240226094, Compound C039::US20250241908, Compound C039::US20250381196, Compound C039 Alpha-protein kinase 1 Homo sapiens 36.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662550 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662550&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407544 496703799 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120368 Cc1ccc(cc1)[C@@](C)(C#C)c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1 |r| InChI=1S/C25H24F2N4OS/c1-4-25(3,17-7-5-16(2)6-8-17)21-15-33-24(29-21)30-23(32)22-19(26)13-18(14-20(22)27)31-11-9-28-10-12-31/h1,5-8,13-15,28H,9-12H2,2-3H3,(H,29,30,32) YBBHLKIMRXSQIB-UHFFFAOYSA-N 662551 2,6-difluoro-N-[4-[1- methyl-1-(p- tolyl)prop-2- ynyl]thiazol-2-yl]-4- piperazin-1-yl- benzamide::US20240109853, Compound C040::US20240226094, Compound C040::US20250241908, Compound C040::US20250381196, Compound C040 Alpha-protein kinase 1 Homo sapiens 29.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662551 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662551&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407610 496703800 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120369 Cc1ccc(cc1)[C@](C)(C#C)c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1 |r| InChI=1S/C25H24F2N4OS/c1-4-25(3,17-7-5-16(2)6-8-17)21-15-33-24(29-21)30-23(32)22-19(26)13-18(14-20(22)27)31-11-9-28-10-12-31/h1,5-8,13-15,28H,9-12H2,2-3H3,(H,29,30,32) YBBHLKIMRXSQIB-UHFFFAOYSA-N 662552 2,6-difluoro-N-[4-[1- methyl-1-(p- tolyl)prop-2- ynyl]thiazol-2-yl]-4- piperazin-1-yl- benzamide::US20240109853, Compound C041::US20240226094, Compound C041::US20250241908, Compound C041::US20250381196, Compound C041 Alpha-protein kinase 1 Homo sapiens 7.00 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662552 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662552&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407701 496703801 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120370 CC(C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(cc1)C#C InChI=1S/C26H22F2N4OS/c1-4-17-6-8-18(9-7-17)26(3,5-2)22-16-34-25(30-22)31-24(33)23-20(27)14-19(15-21(23)28)32-12-10-29-11-13-32/h1-2,6-9,14-16,29H,10-13H2,3H3,(H,30,31,33) CKRYPVKDCSMDER-UHFFFAOYSA-N 662553 N-[4-[1-(4- ethynylphenyl)-1- methyl-prop-2- ynyl]thiazol-2-yl]-2,6- difluoro-4-piperazin- 1-yl-benzamide::US20240109853, Compound C042::US20240226094, Compound C042::US20250241908, Compound C042::US20250381196, Compound C042 Alpha-protein kinase 1 Homo sapiens 101 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662553 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662553&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407811 496703802 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120371 C[C@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1F |r| InChI=1S/C24H20ClF3N4OS/c1-3-24(2,16-5-4-14(25)10-17(16)26)20-13-34-23(30-20)31-22(33)21-18(27)11-15(12-19(21)28)32-8-6-29-7-9-32/h1,4-5,10-13,29H,6-9H2,2H3,(H,30,31,33) WMODPZSBRQFWFS-UHFFFAOYSA-N 662554 N-(4-(2-(4-chloro-2- fluorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C043::US20240226094, Compound C043::US20250241908, Compound C043::US20250381196, Compound C043 Alpha-protein kinase 1 Homo sapiens 285 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662554 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662554&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407834 496703803 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120372 C[C@@](C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1F |r| InChI=1S/C24H20ClF3N4OS/c1-3-24(2,16-5-4-14(25)10-17(16)26)20-13-34-23(30-20)31-22(33)21-18(27)11-15(12-19(21)28)32-8-6-29-7-9-32/h1,4-5,10-13,29H,6-9H2,2H3,(H,30,31,33) WMODPZSBRQFWFS-UHFFFAOYSA-N 662555 N-(4-(2-(4-chloro-2- fluorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C044::US20240226094, Compound C044::US20250241908, Compound C044::US20250381196, Compound C044 Alpha-protein kinase 1 Homo sapiens 25.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662555 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662555&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407377 496703804 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120373 CC(C1CC1)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C25H25ClF2N4OS/c1-25(15-2-3-15,16-4-6-17(26)7-5-16)21-14-34-24(30-21)31-23(33)22-19(27)12-18(13-20(22)28)32-10-8-29-9-11-32/h4-7,12-15,29H,2-3,8-11H2,1H3,(H,30,31,33) ZTLBDTWHNUHJQE-UHFFFAOYSA-N 662556 N-(4-(1-(4- chlorophenyl)-1- cyclopropylethyl)thia- zol-2-yl)-2,6-difluoro- 4-(piperazin-1- yl)benzamide::US20240109853, Compound C045::US20240226094, Compound C045::US20250241908, Compound C045::US20250381196, Compound C045 Alpha-protein kinase 1 Homo sapiens 25.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662556 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662556&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407869 496703805 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120374 CC(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)(c1ccccc1)c1ccc(Cl)cc1 InChI=1S/C28H25ClF2N4OS/c1-28(18-5-3-2-4-6-18,19-7-9-20(29)10-8-19)24-17-37-27(33-24)34-26(36)25-22(30)15-21(16-23(25)31)35-13-11-32-12-14-35/h2-10,15-17,32H,11-14H2,1H3,(H,33,34,36) FAVNFDCVRGYBRV-UHFFFAOYSA-N 662557 N-(4-(1-(4- chlorophenyl)-1- phenylethyl)thiazol-2- yl)-2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C046::US20240226094, Compound C046::US20250241908, Compound C046::US20250381196, Compound C046 Alpha-protein kinase 1 Homo sapiens 377 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662557 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662557&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407656 496703806 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120375 CCC(C#C)(c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1)c1ccc(Cl)cc1 InChI=1S/C25H23ClF2N4OS/c1-3-25(4-2,16-5-7-17(26)8-6-16)21-15-34-24(30-21)31-23(33)22-19(27)13-18(14-20(22)28)32-11-9-29-10-12-32/h1,5-8,13-15,29H,4,9-12H2,2H3,(H,30,31,33) QEVPQRCEIHXDCI-UHFFFAOYSA-N 662558 N-(4-(3-(4- chlorophenyl)pent-1- yn-3-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C047::US20240226094, Compound C047::US20250241908, Compound C047::US20250381196, Compound C047 Alpha-protein kinase 1 Homo sapiens 131 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662558&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407630 496703807 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120376 COc1ccc(cc1)[C@](C)(C#C)c1csc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)n1 |r| InChI=1S/C25H24F2N4O2S/c1-4-25(2,16-5-7-18(33-3)8-6-16)21-15-34-24(29-21)30-23(32)22-19(26)13-17(14-20(22)27)31-11-9-28-10-12-31/h1,5-8,13-15,28H,9-12H2,2-3H3,(H,29,30,32) NWVLNCVDYNKJJY-UHFFFAOYSA-N 662547 US20240109853, Compound C036::2,6-difluoro-N-[4-[1- (4-methoxyphenyl)-1- methyl-prop-2- ynyl]thiazol-2-yl]-4- piperazin-1-yl- benzamide::US20240109853, Compound C048::US20240226094, Compound C048::US20250381196, Compound C048 Alpha-protein kinase 1 Homo sapiens 16.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662547 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662547&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407697 496703796 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120377 C[C@](C#C)(c1nc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)sc1Cl)c1ccc(Cl)cc1 |r| InChI=1S/C24H20Cl2F2N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-21(26)34-23(30-20)31-22(33)19-17(27)12-16(13-18(19)28)32-10-8-29-9-11-32/h1,4-7,12-13,29H,8-11H2,2H3,(H,30,31,33) FSVCKSNEGJPVJZ-UHFFFAOYSA-N 662560 N-(5-chloro-4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C049::US20240226094, Compound C049::US20250241908, Compound C049::US20250381196, Compound C050 Alpha-protein kinase 1 Homo sapiens 4524 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662560 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662560&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407541 496703808 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120378 C[C@](C#C)(c1nc(NC(=O)c2c(F)cc(cc2F)N2CCNCC2)sc1Cl)c1ccc(Cl)cc1 |r| InChI=1S/C24H20Cl2F2N4OS/c1-3-24(2,14-4-6-15(25)7-5-14)20-21(26)34-23(30-20)31-22(33)19-17(27)12-16(13-18(19)28)32-10-8-29-9-11-32/h1,4-7,12-13,29H,8-11H2,2H3,(H,30,31,33) FSVCKSNEGJPVJZ-UHFFFAOYSA-N 662560 N-(5-chloro-4-(2-(4- chlorophenyl)but-3- yn-2-yl)thiazol-2-yl)- 2,6-difluoro-4- (piperazin-1- yl)benzamide::US20240109853, Compound C049::US20240226094, Compound C049::US20250241908, Compound C049::US20250381196, Compound C050 Alpha-protein kinase 1 Homo sapiens 923 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662560 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662560&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407541 496703808 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120379 CC(=O)Nc1nc(cs1)C(C)(C)c1ccc(Br)cc1 InChI=1S/C14H15BrN2OS/c1-9(18)16-13-17-12(8-19-13)14(2,3)10-4-6-11(15)7-5-10/h4-8H,1-3H3,(H,16,17,18) LBZMYIUVRRQGMJ-UHFFFAOYSA-N 662564 N-(4-(2-(4- bromophenyl)propan-2- yl)thiazol-2-yl)acetamide::US20240109853, Compound D001::US20240226094, Compound D001::US20250241908, Compound D001::US20250381196, Compound D001 Alpha-protein kinase 1 Homo sapiens 100.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662564 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662564&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407489 496703811 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120380 COc1ccc(cc1)C(C)(C#C)c1csc(NC(C)=O)n1 InChI=1S/C16H16N2O2S/c1-5-16(3,12-6-8-13(20-4)9-7-12)14-10-21-15(18-14)17-11(2)19/h1,6-10H,2-4H3,(H,17,18,19) FQAVQCZRVFKFJA-UHFFFAOYSA-N 662565 N-(4-(2-(4- methoxyphenyl)but-3-yn-2- yl)thiazol-2-yl)acetamide::US20240109853, Compound D002::US20240226094, Compound D002::US20250241908, Compound D002::US20250381196, Compound D002 Alpha-protein kinase 1 Homo sapiens 196 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662565&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407699 496703812 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120381 CC(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Br)cc1F InChI=1S/C15H12BrFN2OS/c1-4-15(3,11-6-5-10(16)7-12(11)17)13-8-21-14(19-13)18-9(2)20/h1,5-8H,2-3H3,(H,18,19,20) BWMQHLBIDCMCIA-UHFFFAOYSA-N 662566 N-(4-(2-(4-bromo-2- fluorophenyl)but-3-yn-2- yl)thiazol-2-yl)acetamide::US20240109853, Compound D003::US20240226094, Compound D003::US20250241908, Compound D003::US20250381196, Compound D003 Alpha-protein kinase 1 Homo sapiens 183 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662566&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407631 496703813 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120382 CC(=O)Nc1nc(cs1)C(C)(C#C)c1ccc(Cl)cc1 InChI=1S/C15H13ClN2OS/c1-4-15(3,11-5-7-12(16)8-6-11)13-9-20-14(18-13)17-10(2)19/h1,5-9H,2-3H3,(H,17,18,19) PTACHOHDVUVNSJ-UHFFFAOYSA-N 685067 N-(4-(2-(4-chlorophenyl)but- 3-yn-2-yl)thiazol-2- yl)acetamide::US20240226094, Compound D004::US20250241908, Compound D004::US20250381196, Compound D004 Alpha-protein kinase 1 Homo sapiens 18.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=685067 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=685067&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169096271 503274429 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120383 CC(C#C)(c1csc(NC(=O)[C@H]2C[C@H](CO)C2)n1)c1ccc(Br)cc1 |r,wU:13.13,wD:11.10,(4,3.4,;4.77,2.07,;6.26,2.46,;7.75,2.86,;3.24,2.23,;2.47,3.56,;.97,3.24,;.81,1.71,;-.53,.94,;-1.86,1.71,;-1.86,3.25,;-3.2,.94,;-4.68,1.34,;-5.08,-.15,;-6.42,-.92,;-7.75,-.15,;-3.59,-.55,;2.21,1.08,;5.4,.66,;4.5,-.59,;5.12,-1.99,;6.65,-2.15,;7.28,-3.56,;7.56,-.91,;6.93,.5,)| InChI=1S/C19H19BrN2O2S/c1-3-19(2,14-4-6-15(20)7-5-14)16-11-25-18(21-16)22-17(24)13-8-12(9-13)10-23/h1,4-7,11-13,23H,8-10H2,2H3,(H,21,22,24) FMKOLDKMWVAHDD-UHFFFAOYSA-N 662568 rac-(1r,3r)-N-(4-(2-(4- bromophenyl)but-3-yn-2- yl)thiazol-2-yl)-3- (hydroxymethyl)cyclobutane- carboxamide::US20240109853, Compound D005::US20240226094, Compound D005::US20250241908, Compound D005::US20250381196, Compound D005 Alpha-protein kinase 1 Homo sapiens 98.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662568&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221909 496703815 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120384 CC(C#C)(c1csc(NC(=O)[C@@H]2C[C@H](CO)C2)n1)c1ccc(Br)cc1 |r,wU:13.13,11.10,(4,3.4,;4.77,2.07,;6.26,2.46,;7.75,2.86,;3.24,2.23,;2.47,3.56,;.97,3.24,;.81,1.71,;-.53,.94,;-1.86,1.71,;-1.86,3.25,;-3.2,.94,;-4.68,1.34,;-5.08,-.15,;-6.42,-.92,;-7.75,-.15,;-3.59,-.55,;2.21,1.08,;5.4,.66,;4.5,-.59,;5.12,-1.99,;6.65,-2.15,;7.28,-3.56,;7.56,-.91,;6.93,.5,)| InChI=1S/C19H19BrN2O2S/c1-3-19(2,14-4-6-15(20)7-5-14)16-11-25-18(21-16)22-17(24)13-8-12(9-13)10-23/h1,4-7,11-13,23H,8-10H2,2H3,(H,21,22,24) FMKOLDKMWVAHDD-UHFFFAOYSA-N 662569 rac-(1s,3s)-N-(4-(2-(4- bromophenyl)but-3-yn-2- yl)thiazol-2-yl)-3- (hydroxymethyl)cyclobutane- carboxamide::US20240109853, Compound D006::US20240226094, Compound D006::US20250241908, Compound D006::US20250381196, Compound D006 Alpha-protein kinase 1 Homo sapiens 40.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662569&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169221909 496703816 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120385 CC(C#C)(c1csc(NC(=O)C2CC(O)C2)n1)c1ccc(Br)cc1 |(5.4,1.33,;3.86,1.33,;4.63,2.66,;5.4,4,;2.32,1.33,;1.41,2.57,;-.05,2.09,;-.05,.55,;-1.29,-.35,;-2.7,.27,;-2.87,1.8,;-3.95,-.64,;-4.18,-2.16,;-5.71,-1.92,;-6.95,-2.83,;-5.47,-.4,;1.42,.08,;4.63,-0,;3.86,-1.34,;4.64,-2.67,;6.18,-2.67,;6.95,-4,;6.94,-1.33,;6.17,0,)| InChI=1S/C18H17BrN2O2S/c1-3-18(2,12-4-6-13(19)7-5-12)15-10-24-17(20-15)21-16(23)11-8-14(22)9-11/h1,4-7,10-11,14,22H,8-9H2,2H3,(H,20,21,23) UADHUYNTKRKEQV-UHFFFAOYSA-N 662570 N-(4-(2-(4-bromophenyl)but- 3-yn-2-yl)thiazol-2-yl)-3- hydroxycyclobutanecarboxamide::US20240109853, Compound D007::US20240226094, Compound D007::US20250241908, Compound D007::US20250381196, Compound D007 Alpha-protein kinase 1 Homo sapiens 55.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662570&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407642 496703817 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120386 CCC(C#C)(c1csc(NC(C)=O)n1)c1ccc(Br)cc1 InChI=1S/C16H15BrN2OS/c1-4-16(5-2,12-6-8-13(17)9-7-12)14-10-21-15(19-14)18-11(3)20/h1,6-10H,5H2,2-3H3,(H,18,19,20) MECAHGQKPHQJSJ-UHFFFAOYSA-N 662571 N-(4-(3-(4-bromophenyl)pent- 1-yn-3-yl)thiazol-2- yl)acetamide::US20240109853, Compound D008::US20240226094, Compound D008::US20250241908, Compound D008::US20250381196, Compound D008 Alpha-protein kinase 1 Homo sapiens 143 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662571&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 171407760 496703818 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120387 C#CC(C)(c1ccc(Br)cc1)c2csc(NC(C)=O)n2 InChI=1S/C15H13BrN2OS/c1-4-15(3,11-5-7-12(16)8-6-11)13-9-20-14(18-13)17-10(2)19/h1,5-9H,2-3H3,(H,17,18,19) IMJYGHWMHBLITB-UHFFFAOYSA-N 662574 (S)-N-(4-(2-(4- bromophenyl)but-3-yn-2- yl)thiazol-2-yl)acetamide::US20240109853, Compound D011::US20250241908, Compound D011::US20250381196, Compound D011 Alpha-protein kinase 1 Homo sapiens 16.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662574&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120388 C#CC(C)(c1ccc(Br)cc1)c2csc(NC(C)=O)n2 InChI=1S/C15H13BrN2OS/c1-4-15(3,11-5-7-12(16)8-6-11)13-9-20-14(18-13)17-10(2)19/h1,5-9H,2-3H3,(H,17,18,19) IMJYGHWMHBLITB-UHFFFAOYSA-N 662574 (S)-N-(4-(2-(4- bromophenyl)but-3-yn-2- yl)thiazol-2-yl)acetamide::US20240109853, Compound D011::US20250241908, Compound D011::US20250381196, Compound D011 Alpha-protein kinase 1 Homo sapiens 102 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662574&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201 120389 C#CC(C)(c1ccc(Br)cc1)c2csc(NC(C)=O)n2 InChI=1S/C15H13BrN2OS/c1-4-15(3,11-5-7-12(16)8-6-11)13-9-20-14(18-13)17-10(2)19/h1,5-9H,2-3H3,(H,17,18,19) IMJYGHWMHBLITB-UHFFFAOYSA-N 662574 (S)-N-(4-(2-(4- bromophenyl)but-3-yn-2- yl)thiazol-2-yl)acetamide::US20240109853, Compound D011::US20250241908, Compound D011::US20250381196, Compound D011 Alpha-protein kinase 1 Homo sapiens 14.0 US Patent 10.7270/Q2DV1QQF US20250381196 LIU, D; DANG, H; XU, C; MELVIN, LS; FAN, J; WEI, Y; WEI, X; PAN, Y; LICHENSTEIN, H; XU, T 12/18/2025 4/29/2026 Shanghai Yao Yuan Biotechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=662574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1397&target=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=662574&enzyme=Alpha-protein+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 1 MNNQKVVAVLLQECKQVLDQLLLEAPDVSEEDKSEDQRCRALLPSELRTLIQEAKEMKWPFVPEKWQYKQAVGPEDKTNLKDVIGAGLQQLLASLRASILARDCAAAAAIVFLVDRFLYGLDVSGKLLQVAKGLHKLQPATPIAPQVVIRQARISVNSGKLLKAEYILSSLISNNGATGTWLYRNESDKVLVQSVCIQIRGQILQKLGMWYEAAELIWASIVGYLALPQPDKKGLSTSLGILADIFVSMSKNDYEKFKNNPQINLSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPELKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVMSVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKNIDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGFSSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNTPGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEISERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLDSMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWSYLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLTVKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCISVEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFNNQHVECNEICHRLSLTRPSMEKPCT 8ZD3,9J4P,5Z2C Alpha-protein kinase 1 ALPK1_HUMAN Q96QP1 B4E3G1 F5H138 Q68CI9 Q6P9F9 Q6ZNK4 Q9P201