BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 121174 Cc1cc(O)nc2ccc(NC(=O)c3cccnc3N3CCOCC3)cc12 InChI=1S/C20H20N4O3/c1-13-11-18(25)23-17-5-4-14(12-16(13)17)22-20(26)15-3-2-6-21-19(15)24-7-9-27-10-8-24/h2-6,11-12H,7-10H2,1H3,(H,22,26)(H,23,25) OSFZBGUNRGOXKG-UHFFFAOYSA-N 75590 WO2016016316, Compound 128 Bromodomain-containing protein 4 [58-164] Homo sapiens 15.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75590&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 44620890 252652793 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121175 Cc1cc(O)nc2ccc(NC(=O)c3cccnc3N3CCOCC3)cc12 InChI=1S/C20H20N4O3/c1-13-11-18(25)23-17-5-4-14(12-16(13)17)22-20(26)15-3-2-6-21-19(15)24-7-9-27-10-8-24/h2-6,11-12H,7-10H2,1H3,(H,22,26)(H,23,25) OSFZBGUNRGOXKG-UHFFFAOYSA-N 75590 WO2016016316, Compound 128 Bromodomain-containing protein 4 [353-454] Homo sapiens 2500 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75590&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 44620890 252652793 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121176 Cc1cc(O)nc2ccc(NC(=O)c3cccnc3N3CCOCC3)cc12 InChI=1S/C20H20N4O3/c1-13-11-18(25)23-17-5-4-14(12-16(13)17)22-20(26)15-3-2-6-21-19(15)24-7-9-27-10-8-24/h2-6,11-12H,7-10H2,1H3,(H,22,26)(H,23,25) OSFZBGUNRGOXKG-UHFFFAOYSA-N 75590 WO2016016316, Compound 128 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens 441 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75590&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 44620890 252652793 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121177 Cc1cc2nc(O)cc(C)c2cc1NC(=O)c1cc(S(=O)(=O)N(C)C)cnc1N1CCOCC1 InChI=1S/C23H27N5O5S/c1-14-10-21(29)25-20-9-15(2)19(12-17(14)20)26-23(30)18-11-16(34(31,32)27(3)4)13-24-22(18)28-5-7-33-8-6-28/h9-13H,5-8H2,1-4H3,(H,25,29)(H,26,30) MNBFAEGLCXTISD-UHFFFAOYSA-N 75605 WO2016016316, Compound 99 Bromodomain-containing protein 4 [58-164] Homo sapiens 12.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75605&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 44620893 252652808 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121178 Cc1cc2nc(O)cc(C)c2cc1NC(=O)c1cc(S(=O)(=O)N(C)C)cnc1N1CCOCC1 InChI=1S/C23H27N5O5S/c1-14-10-21(29)25-20-9-15(2)19(12-17(14)20)26-23(30)18-11-16(34(31,32)27(3)4)13-24-22(18)28-5-7-33-8-6-28/h9-13H,5-8H2,1-4H3,(H,25,29)(H,26,30) MNBFAEGLCXTISD-UHFFFAOYSA-N 75605 WO2016016316, Compound 99 Bromodomain-containing protein 4 [353-454] Homo sapiens 5600 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75605&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 44620893 252652808 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121179 Cc1cc2nc(O)cc(C)c2cc1NC(=O)c1cc(S(=O)(=O)N(C)C)cnc1N1CCOCC1 InChI=1S/C23H27N5O5S/c1-14-10-21(29)25-20-9-15(2)19(12-17(14)20)26-23(30)18-11-16(34(31,32)27(3)4)13-24-22(18)28-5-7-33-8-6-28/h9-13H,5-8H2,1-4H3,(H,25,29)(H,26,30) MNBFAEGLCXTISD-UHFFFAOYSA-N 75605 WO2016016316, Compound 99 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens 3740 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75605&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 44620893 252652808 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121180 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CNC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H25N5O4/c1-13-7-20(29)27-21-16(13)9-15(10-19(21)31-2)25-23(30)17-8-14-11-24-12-18(14)26-22(17)28-3-5-32-6-4-28/h7-10,24H,3-6,11-12H2,1-2H3,(H,25,30)(H,27,29) PSSRYGPOOAMMPC-UHFFFAOYSA-N 75710 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 1 Bromodomain-containing protein 4 [58-164] Homo sapiens 8.00 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75710&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2026526 252652912 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121181 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CNC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H25N5O4/c1-13-7-20(29)27-21-16(13)9-15(10-19(21)31-2)25-23(30)17-8-14-11-24-12-18(14)26-22(17)28-3-5-32-6-4-28/h7-10,24H,3-6,11-12H2,1-2H3,(H,25,30)(H,27,29) PSSRYGPOOAMMPC-UHFFFAOYSA-N 75710 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 1 Bromodomain-containing protein 4 [353-454] Homo sapiens 600 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75710&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2026526 252652912 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121182 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CNC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H25N5O4/c1-13-7-20(29)27-21-16(13)9-15(10-19(21)31-2)25-23(30)17-8-14-11-24-12-18(14)26-22(17)28-3-5-32-6-4-28/h7-10,24H,3-6,11-12H2,1-2H3,(H,25,30)(H,27,29) PSSRYGPOOAMMPC-UHFFFAOYSA-N 75710 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 1 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75710 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75710&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 2026526 252652912 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121183 COc1cc(NC(=O)c2cc3c(nc2C2=CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H23N3O5/c1-13-7-21(28)27-23-17(13)9-16(10-20(23)30-2)25-24(29)18-8-15-11-32-12-19(15)26-22(18)14-3-5-31-6-4-14/h3,7-10H,4-6,11-12H2,1-2H3,(H,25,29)(H,27,28) BUGDXSVNEKTWMQ-UHFFFAOYSA-N 75805 2-(3,6-dihydro-2H-pyran-4-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 2 Bromodomain-containing protein 4 [58-164] Homo sapiens 64.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75805&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 12006241 252653001 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121184 COc1cc(NC(=O)c2cc3c(nc2C2=CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H23N3O5/c1-13-7-21(28)27-23-17(13)9-16(10-20(23)30-2)25-24(29)18-8-15-11-32-12-19(15)26-22(18)14-3-5-31-6-4-14/h3,7-10H,4-6,11-12H2,1-2H3,(H,25,29)(H,27,28) BUGDXSVNEKTWMQ-UHFFFAOYSA-N 75805 2-(3,6-dihydro-2H-pyran-4-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 2 Bromodomain-containing protein 4 [353-454] Homo sapiens 2600 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75805&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 12006241 252653001 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121185 COc1cc(NC(=O)c2cc3c(nc2C2=CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H23N3O5/c1-13-7-21(28)27-23-17(13)9-16(10-20(23)30-2)25-24(29)18-8-15-11-32-12-19(15)26-22(18)14-3-5-31-6-4-14/h3,7-10H,4-6,11-12H2,1-2H3,(H,25,29)(H,27,28) BUGDXSVNEKTWMQ-UHFFFAOYSA-N 75805 2-(3,6-dihydro-2H-pyran-4-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 2 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75805&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 12006241 252653001 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121186 COc1cc(NC(=O)c2cc3c(nc2C2=CCCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H23N3O4/c1-13-7-21(28)27-23-17(13)9-16(10-20(23)30-2)25-24(29)18-8-15-11-31-12-19(15)26-22(18)14-5-3-4-6-14/h5,7-10H,3-4,6,11-12H2,1-2H3,(H,25,29)(H,27,28) FPVRDOKEJYCCIL-UHFFFAOYSA-N 75806 2-(cyclopenten-1-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 3 Bromodomain-containing protein 4 [58-164] Homo sapiens 13.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75806&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 5602439 252653002 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121187 COc1cc(NC(=O)c2cc3c(nc2C2=CCCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H23N3O4/c1-13-7-21(28)27-23-17(13)9-16(10-20(23)30-2)25-24(29)18-8-15-11-31-12-19(15)26-22(18)14-5-3-4-6-14/h5,7-10H,3-4,6,11-12H2,1-2H3,(H,25,29)(H,27,28) FPVRDOKEJYCCIL-UHFFFAOYSA-N 75806 2-(cyclopenten-1-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 3 Bromodomain-containing protein 4 [353-454] Homo sapiens 800 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75806&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 5602439 252653002 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121188 COc1cc(NC(=O)c2cc3c(nc2N2CC4CC2(C)C4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O4/c1-13-4-21(30)28-22-17(13)6-16(7-20(22)32-3)26-24(31)18-5-15-11-33-12-19(15)27-23(18)29-10-14-8-25(29,2)9-14/h4-7,14H,8-12H2,1-3H3,(H,26,31)(H,28,30) JIFQHMFJMSSSEA-UHFFFAOYSA-N 75809 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-(1-methyl-2-azabicyclo[2.1.1]hexan-2-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 4 Bromodomain-containing protein 4 [58-164] Homo sapiens 29.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75809&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2339127 252653005 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121189 COc1cc(NC(=O)c2cc3c(nc2N2CC4CC2(C)C4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O4/c1-13-4-21(30)28-22-17(13)6-16(7-20(22)32-3)26-24(31)18-5-15-11-33-12-19(15)27-23(18)29-10-14-8-25(29,2)9-14/h4-7,14H,8-12H2,1-3H3,(H,26,31)(H,28,30) JIFQHMFJMSSSEA-UHFFFAOYSA-N 75809 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-(1-methyl-2-azabicyclo[2.1.1]hexan-2-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 4 Bromodomain-containing protein 4 [353-454] Homo sapiens >5000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75809&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2339127 252653005 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121190 COc1cc(NC(=O)c2cc3c(nc2N2CC4C(C2)C4(F)F)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H22F2N4O4/c1-11-3-20(31)29-21-14(11)5-13(6-19(21)33-2)27-23(32)15-4-12-9-34-10-18(12)28-22(15)30-7-16-17(8-30)24(16,25)26/h3-6,16-17H,7-10H2,1-2H3,(H,27,32)(H,29,31) HWWRCAOCUIHREP-UHFFFAOYSA-N 75810 2-(6,6-difluoro-3-azabicyclo[3.1.0]hexan-3-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 5 Bromodomain-containing protein 4 [58-164] Homo sapiens 17.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75810 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75810&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2466937 252653006 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121191 COc1cc(NC(=O)c2cc3c(nc2N2CC4C(C2)C4(F)F)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H22F2N4O4/c1-11-3-20(31)29-21-14(11)5-13(6-19(21)33-2)27-23(32)15-4-12-9-34-10-18(12)28-22(15)30-7-16-17(8-30)24(16,25)26/h3-6,16-17H,7-10H2,1-2H3,(H,27,32)(H,29,31) HWWRCAOCUIHREP-UHFFFAOYSA-N 75810 2-(6,6-difluoro-3-azabicyclo[3.1.0]hexan-3-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 5 Bromodomain-containing protein 4 [353-454] Homo sapiens 200 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75810 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75810&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2466937 252653006 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121192 COc1cc(NC(=O)c2cc3c(nc2N(C)C)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C21H22N4O4/c1-11-5-18(26)24-19-14(11)7-13(8-17(19)28-4)22-21(27)15-6-12-9-29-10-16(12)23-20(15)25(2)3/h5-8H,9-10H2,1-4H3,(H,22,27)(H,24,26) MWOCMBCJLSVRRV-UHFFFAOYSA-N 75811 2-(dimethylamino)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 6 Bromodomain-containing protein 4 [58-164] Homo sapiens 120 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75811&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 1211193 252653007 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121193 COc1cc(NC(=O)c2cc3c(nc2N(C)C)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C21H22N4O4/c1-11-5-18(26)24-19-14(11)7-13(8-17(19)28-4)22-21(27)15-6-12-9-29-10-16(12)23-20(15)25(2)3/h5-8H,9-10H2,1-4H3,(H,22,27)(H,24,26) MWOCMBCJLSVRRV-UHFFFAOYSA-N 75811 2-(dimethylamino)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 6 Bromodomain-containing protein 4 [353-454] Homo sapiens 1300 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75811&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 1211193 252653007 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121194 COc1cc(NC(=O)c2cc3c(nc2N(C)C)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C21H22N4O4/c1-11-5-18(26)24-19-14(11)7-13(8-17(19)28-4)22-21(27)15-6-12-9-29-10-16(12)23-20(15)25(2)3/h5-8H,9-10H2,1-4H3,(H,22,27)(H,24,26) MWOCMBCJLSVRRV-UHFFFAOYSA-N 75811 2-(dimethylamino)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 6 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75811&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 1211193 252653007 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121195 Cc1cc(=O)[nH]c2c(C)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C23H24N4O4/c1-13-8-20(28)26-21-14(2)7-16(10-17(13)21)24-23(29)18-9-15-11-31-12-19(15)25-22(18)27-3-5-30-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,29)(H,26,28) XOAXIABELQUDNI-UHFFFAOYSA-N 75813 N-(4,8-dimethyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 7 Bromodomain-containing protein 4 [58-164] Homo sapiens 40.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75813&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2275963 252653009 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121196 Cc1cc(=O)[nH]c2c(C)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C23H24N4O4/c1-13-8-20(28)26-21-14(2)7-16(10-17(13)21)24-23(29)18-9-15-11-31-12-19(15)25-22(18)27-3-5-30-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,29)(H,26,28) XOAXIABELQUDNI-UHFFFAOYSA-N 75813 N-(4,8-dimethyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 7 Bromodomain-containing protein 4 [353-454] Homo sapiens 7100 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75813&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2275963 252653009 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121197 Cc1cc(=O)[nH]c2c(C)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C23H24N4O4/c1-13-8-20(28)26-21-14(2)7-16(10-17(13)21)24-23(29)18-9-15-11-31-12-19(15)25-22(18)27-3-5-30-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,29)(H,26,28) XOAXIABELQUDNI-UHFFFAOYSA-N 75813 N-(4,8-dimethyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 7 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75813&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 2275963 252653009 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121198 Cc1cc(=O)[nH]c2c3c(c(NC(=O)c4cc5c(nc4N4CCOCC4)COC5)cc12)CCO3 InChI=1S/C24H24N4O5/c1-13-8-20(29)27-21-16(13)10-18(15-2-5-33-22(15)21)26-24(30)17-9-14-11-32-12-19(14)25-23(17)28-3-6-31-7-4-28/h8-10H,2-7,11-12H2,1H3,(H,26,30)(H,27,29) CGHMRPSTUMFXSA-UHFFFAOYSA-N 75814 N-(6-methyl-8-oxo-3,9-dihydro-2H-furo[3,2-h]quinolin-4-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 8 Bromodomain-containing protein 4 [58-164] Homo sapiens 56.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75814&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 91898152 252653010 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121199 Cc1cc(=O)[nH]c2c3c(c(NC(=O)c4cc5c(nc4N4CCOCC4)COC5)cc12)CCO3 InChI=1S/C24H24N4O5/c1-13-8-20(29)27-21-16(13)10-18(15-2-5-33-22(15)21)26-24(30)17-9-14-11-32-12-19(14)25-23(17)28-3-6-31-7-4-28/h8-10H,2-7,11-12H2,1H3,(H,26,30)(H,27,29) CGHMRPSTUMFXSA-UHFFFAOYSA-N 75814 N-(6-methyl-8-oxo-3,9-dihydro-2H-furo[3,2-h]quinolin-4-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 8 Bromodomain-containing protein 4 [353-454] Homo sapiens >2500 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75814&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 91898152 252653010 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121200 COc1c(F)c(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H23FN4O5/c1-12-7-18(29)27-20-14(12)9-16(19(24)21(20)31-2)26-23(30)15-8-13-10-33-11-17(13)25-22(15)28-3-5-32-6-4-28/h7-9H,3-6,10-11H2,1-2H3,(H,26,30)(H,27,29) MVNUWAWZDTUMMO-UHFFFAOYSA-N 75815 N-(7-fluoro-8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 9 Bromodomain-containing protein 4 [58-164] Homo sapiens 440 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75815&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 6393134 252653011 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121201 COc1c(F)c(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H23FN4O5/c1-12-7-18(29)27-20-14(12)9-16(19(24)21(20)31-2)26-23(30)15-8-13-10-33-11-17(13)25-22(15)28-3-5-32-6-4-28/h7-9H,3-6,10-11H2,1-2H3,(H,26,30)(H,27,29) MVNUWAWZDTUMMO-UHFFFAOYSA-N 75815 N-(7-fluoro-8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 9 Bromodomain-containing protein 4 [353-454] Homo sapiens 7400 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75815&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 6393134 252653011 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121202 Cc1cc(=O)[nH]c2c3c(c(NC(=O)c4cc5c(nc4N4CCOCC4)COC5)cc12)OCCO3 InChI=1S/C24H24N4O6/c1-13-8-19(29)27-20-15(13)10-17(21-22(20)34-7-6-33-21)26-24(30)16-9-14-11-32-12-18(14)25-23(16)28-2-4-31-5-3-28/h8-10H,2-7,11-12H2,1H3,(H,26,30)(H,27,29) IDZTWYLXDHWRIN-UHFFFAOYSA-N 75816 N-(7-methyl-9-oxo-3,10-dihydro-2H-[1,4]dioxino[2,3-h]quinolin-5-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 10 Bromodomain-containing protein 4 [58-164] Homo sapiens 43.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75816 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75816&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2823713 252653012 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121203 Cc1cc(=O)[nH]c2c3c(c(NC(=O)c4cc5c(nc4N4CCOCC4)COC5)cc12)OCCO3 InChI=1S/C24H24N4O6/c1-13-8-19(29)27-20-15(13)10-17(21-22(20)34-7-6-33-21)26-24(30)16-9-14-11-32-12-18(14)25-23(16)28-2-4-31-5-3-28/h8-10H,2-7,11-12H2,1H3,(H,26,30)(H,27,29) IDZTWYLXDHWRIN-UHFFFAOYSA-N 75816 N-(7-methyl-9-oxo-3,10-dihydro-2H-[1,4]dioxino[2,3-h]quinolin-5-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 10 Bromodomain-containing protein 4 [353-454] Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75816 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75816&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2823713 252653012 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121204 Cc1cc2[nH]c(=O)cc(C)c2cc1NC(=O)c1cc2c(nc1N1CCOCC1)COC2 InChI=1S/C23H24N4O4/c1-13-8-21(28)24-19-7-14(2)18(10-16(13)19)26-23(29)17-9-15-11-31-12-20(15)25-22(17)27-3-5-30-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,28)(H,26,29) NQVDCNPOYIICFA-UHFFFAOYSA-N 75817 N-(4,7-dimethyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 11 Bromodomain-containing protein 4 [58-164] Homo sapiens 90.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75817&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 1360981 252653013 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121205 Cc1cc2[nH]c(=O)cc(C)c2cc1NC(=O)c1cc2c(nc1N1CCOCC1)COC2 InChI=1S/C23H24N4O4/c1-13-8-21(28)24-19-7-14(2)18(10-16(13)19)26-23(29)17-9-15-11-31-12-20(15)25-22(17)27-3-5-30-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,28)(H,26,29) NQVDCNPOYIICFA-UHFFFAOYSA-N 75817 N-(4,7-dimethyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 11 Bromodomain-containing protein 4 [353-454] Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75817&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 1360981 252653013 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121206 Cc1cc2[nH]c(=O)cc(C)c2cc1NC(=O)c1cc2c(nc1N1CCOCC1)COC2 InChI=1S/C23H24N4O4/c1-13-8-21(28)24-19-7-14(2)18(10-16(13)19)26-23(29)17-9-15-11-31-12-20(15)25-22(17)27-3-5-30-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,28)(H,26,29) NQVDCNPOYIICFA-UHFFFAOYSA-N 75817 N-(4,7-dimethyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 11 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens 7000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75817 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75817&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 1360981 252653013 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121207 CCOc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O5/c1-3-33-20-11-16(10-17-14(2)8-21(29)27-22(17)20)25-24(30)18-9-15-12-32-13-19(15)26-23(18)28-4-6-31-7-5-28/h8-11H,3-7,12-13H2,1-2H3,(H,25,30)(H,27,29) KMHBGHLJEDCWCC-UHFFFAOYSA-N 75818 N-(8-ethoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 12 Bromodomain-containing protein 4 [58-164] Homo sapiens 87.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75818&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 5344735 252653014 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121208 CCOc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O5/c1-3-33-20-11-16(10-17-14(2)8-21(29)27-22(17)20)25-24(30)18-9-15-12-32-13-19(15)26-23(18)28-4-6-31-7-5-28/h8-11H,3-7,12-13H2,1-2H3,(H,25,30)(H,27,29) KMHBGHLJEDCWCC-UHFFFAOYSA-N 75818 N-(8-ethoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 12 Bromodomain-containing protein 4 [353-454] Homo sapiens 8100 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75818&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 5344735 252653014 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121209 CCOc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O5/c1-3-33-20-11-16(10-17-14(2)8-21(29)27-22(17)20)25-24(30)18-9-15-12-32-13-19(15)26-23(18)28-4-6-31-7-5-28/h8-11H,3-7,12-13H2,1-2H3,(H,25,30)(H,27,29) KMHBGHLJEDCWCC-UHFFFAOYSA-N 75818 N-(8-ethoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 12 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75818 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75818&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 5344735 252653014 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121210 Cc1c(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c2c1C InChI=1S/C24H26N4O4/c1-13-8-21(29)27-22-15(3)14(2)19(10-17(13)22)26-24(30)18-9-16-11-32-12-20(16)25-23(18)28-4-6-31-7-5-28/h8-10H,4-7,11-12H2,1-3H3,(H,26,30)(H,27,29) RXCUEHNKPPLWFD-UHFFFAOYSA-N 75819 2-morpholino-N-(4,7,8-trimethyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 13 Bromodomain-containing protein 4 [58-164] Homo sapiens 280 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75819&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 5749163 252653015 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121211 Cc1c(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c2c1C InChI=1S/C24H26N4O4/c1-13-8-21(29)27-22-15(3)14(2)19(10-17(13)22)26-24(30)18-9-16-11-32-12-20(16)25-23(18)28-4-6-31-7-5-28/h8-10H,4-7,11-12H2,1-3H3,(H,26,30)(H,27,29) RXCUEHNKPPLWFD-UHFFFAOYSA-N 75819 2-morpholino-N-(4,7,8-trimethyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 13 Bromodomain-containing protein 4 [353-454] Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75819&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 5749163 252653015 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121212 Cc1c(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c2c1C InChI=1S/C24H26N4O4/c1-13-8-21(29)27-22-15(3)14(2)19(10-17(13)22)26-24(30)18-9-16-11-32-12-20(16)25-23(18)28-4-6-31-7-5-28/h8-10H,4-7,11-12H2,1-3H3,(H,26,30)(H,27,29) RXCUEHNKPPLWFD-UHFFFAOYSA-N 75819 2-morpholino-N-(4,7,8-trimethyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 13 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75819 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75819&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 5749163 252653015 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121213 COc1cc2[nH]c(=O)cc(C)c2cc1NC(=O)c1cc2c(nc1N1CCOCC1)COC2 InChI=1S/C23H24N4O5/c1-13-7-21(28)24-17-10-20(30-2)18(9-15(13)17)26-23(29)16-8-14-11-32-12-19(14)25-22(16)27-3-5-31-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,28)(H,26,29) GOSHIWGHDJFXOM-UHFFFAOYSA-N 75823 N-(7-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 14 Bromodomain-containing protein 4 [58-164] Homo sapiens 26.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75823&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 1477556 252653019 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121214 COc1cc2[nH]c(=O)cc(C)c2cc1NC(=O)c1cc2c(nc1N1CCOCC1)COC2 InChI=1S/C23H24N4O5/c1-13-7-21(28)24-17-10-20(30-2)18(9-15(13)17)26-23(29)16-8-14-11-32-12-19(14)25-22(16)27-3-5-31-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,28)(H,26,29) GOSHIWGHDJFXOM-UHFFFAOYSA-N 75823 N-(7-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 14 Bromodomain-containing protein 4 [353-454] Homo sapiens 400 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75823 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75823&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 1477556 252653019 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121215 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H24N4O5/c1-13-7-20(28)26-21-16(13)9-15(10-19(21)30-2)24-23(29)17-8-14-11-32-12-18(14)25-22(17)27-3-5-31-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,29)(H,26,28) FSVYXEINDOJHNL-UHFFFAOYSA-N 75824 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 15 Bromodomain-containing protein 4 [58-164] Homo sapiens 14.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75824&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 4303517 252653020 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121216 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H24N4O5/c1-13-7-20(28)26-21-16(13)9-15(10-19(21)30-2)24-23(29)17-8-14-11-32-12-18(14)25-22(17)27-3-5-31-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,29)(H,26,28) FSVYXEINDOJHNL-UHFFFAOYSA-N 75824 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 15 Bromodomain-containing protein 4 [353-454] Homo sapiens 2200 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75824&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 4303517 252653020 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121217 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H24N4O5/c1-13-7-20(28)26-21-16(13)9-15(10-19(21)30-2)24-23(29)17-8-14-11-32-12-18(14)25-22(17)27-3-5-31-6-4-27/h7-10H,3-6,11-12H2,1-2H3,(H,24,29)(H,26,28) FSVYXEINDOJHNL-UHFFFAOYSA-N 75824 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 15 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75824&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 4303517 252653020 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121218 COc1cc(NC(=O)c2cc3c(nc2N2CCC(F)(F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H22F2N4O4/c1-12-5-19(30)28-20-15(12)7-14(8-18(20)32-2)26-22(31)16-6-13-9-33-10-17(13)27-21(16)29-4-3-23(24,25)11-29/h5-8H,3-4,9-11H2,1-2H3,(H,26,31)(H,28,30) QACBRLMLAGXUHM-UHFFFAOYSA-N 75826 2-(3,3-difluoropyrrolidin-1-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 16 Bromodomain-containing protein 4 [58-164] Homo sapiens 21.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75826&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2421297 252653022 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121219 COc1cc(NC(=O)c2cc3c(nc2N2CCC(F)(F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H22F2N4O4/c1-12-5-19(30)28-20-15(12)7-14(8-18(20)32-2)26-22(31)16-6-13-9-33-10-17(13)27-21(16)29-4-3-23(24,25)11-29/h5-8H,3-4,9-11H2,1-2H3,(H,26,31)(H,28,30) QACBRLMLAGXUHM-UHFFFAOYSA-N 75826 2-(3,3-difluoropyrrolidin-1-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 16 Bromodomain-containing protein 4 [353-454] Homo sapiens 900 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75826&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2421297 252653022 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121220 COc1cc(NC(=O)c2cc3c(nc2N2C4CCC2COC4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-5-22(30)28-23-18(13)7-15(8-21(23)32-2)26-25(31)19-6-14-9-33-12-20(14)27-24(19)29-16-3-4-17(29)11-34-10-16/h5-8,16-17H,3-4,9-12H2,1-2H3,(H,26,31)(H,28,30) RHIHJAKNEGMBLE-UHFFFAOYSA-N 75827 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 17 Bromodomain-containing protein 4 [58-164] Homo sapiens 25.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75827&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 4878098 252653023 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121221 COc1cc(NC(=O)c2cc3c(nc2N2C4CCC2COC4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-5-22(30)28-23-18(13)7-15(8-21(23)32-2)26-25(31)19-6-14-9-33-12-20(14)27-24(19)29-16-3-4-17(29)11-34-10-16/h5-8,16-17H,3-4,9-12H2,1-2H3,(H,26,31)(H,28,30) RHIHJAKNEGMBLE-UHFFFAOYSA-N 75827 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 17 Bromodomain-containing protein 4 [353-454] Homo sapiens 1100 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75827&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 4878098 252653023 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121222 COc1cc(NC(=O)c2cc3c(nc2N2C4CCC2COC4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-5-22(30)28-23-18(13)7-15(8-21(23)32-2)26-25(31)19-6-14-9-33-12-20(14)27-24(19)29-16-3-4-17(29)11-34-10-16/h5-8,16-17H,3-4,9-12H2,1-2H3,(H,26,31)(H,28,30) RHIHJAKNEGMBLE-UHFFFAOYSA-N 75827 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 17 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75827&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 4878098 252653023 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121223 COc1cc(NC(=O)c2cc3c(nc2N2CCC[C@H]2C)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-13-7-21(29)27-22-17(13)9-16(10-20(22)31-3)25-24(30)18-8-15-11-32-12-19(15)26-23(18)28-6-4-5-14(28)2/h7-10,14H,4-6,11-12H2,1-3H3,(H,25,30)(H,27,29) NNILHNCBNHPDLZ-UHFFFAOYSA-N 75828 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(2R)-2-methylpyrrolidin-1-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 18 Bromodomain-containing protein 4 [58-164] Homo sapiens 12.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75828&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2089384 252653024 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121224 COc1cc(NC(=O)c2cc3c(nc2N2CCC[C@H]2C)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-13-7-21(29)27-22-17(13)9-16(10-20(22)31-3)25-24(30)18-8-15-11-32-12-19(15)26-23(18)28-6-4-5-14(28)2/h7-10,14H,4-6,11-12H2,1-3H3,(H,25,30)(H,27,29) NNILHNCBNHPDLZ-UHFFFAOYSA-N 75828 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(2R)-2-methylpyrrolidin-1-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 18 Bromodomain-containing protein 4 [353-454] Homo sapiens 200 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75828&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2089384 252653024 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121225 COc1cc(NC(=O)c2cc3c(nc2N2CC4CCOC4C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-5-22(30)28-23-17(13)7-16(8-20(23)32-2)26-25(31)18-6-15-11-33-12-19(15)27-24(18)29-9-14-3-4-34-21(14)10-29/h5-8,14,21H,3-4,9-12H2,1-2H3,(H,26,31)(H,28,30) RRQUPGQMFPDMDK-UHFFFAOYSA-N 75829 2-(2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 19 Bromodomain-containing protein 4 [58-164] Homo sapiens 180 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75829&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 3996045 252653025 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121226 COc1cc(NC(=O)c2cc3c(nc2N2CC4CCOC4C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-5-22(30)28-23-17(13)7-16(8-20(23)32-2)26-25(31)18-6-15-11-33-12-19(15)27-24(18)29-9-14-3-4-34-21(14)10-29/h5-8,14,21H,3-4,9-12H2,1-2H3,(H,26,31)(H,28,30) RRQUPGQMFPDMDK-UHFFFAOYSA-N 75829 2-(2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 19 Bromodomain-containing protein 4 [353-454] Homo sapiens 5600 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75829&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 3996045 252653025 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121227 COc1cc(NC(=O)c2cc3c(nc2N2CC4COCC4C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-3-22(30)28-23-18(13)5-17(6-21(23)32-2)26-25(31)19-4-14-9-34-12-20(14)27-24(19)29-7-15-10-33-11-16(15)8-29/h3-6,15-16H,7-12H2,1-2H3,(H,26,31)(H,28,30) MIRZQCIHFKKWLN-UHFFFAOYSA-N 75830 2-(1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrol-5-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 20 Bromodomain-containing protein 4 [58-164] Homo sapiens 70.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75830&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 4970052 252653026 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121228 COc1cc(NC(=O)c2cc3c(nc2N2CC4COCC4C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-3-22(30)28-23-18(13)5-17(6-21(23)32-2)26-25(31)19-4-14-9-34-12-20(14)27-24(19)29-7-15-10-33-11-16(15)8-29/h3-6,15-16H,7-12H2,1-2H3,(H,26,31)(H,28,30) MIRZQCIHFKKWLN-UHFFFAOYSA-N 75830 2-(1,3,3a,4,6,6a-hexahydrofuro[3,4-c]pyrrol-5-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 20 Bromodomain-containing protein 4 [353-454] Homo sapiens 3400 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75830 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75830&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 4970052 252653026 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121229 COc1cc(NC(=O)c2cc3c(nc2N2C4CCCC2CC4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C26H28N4O4/c1-14-8-23(31)29-24-19(14)10-16(11-22(24)33-2)27-26(32)20-9-15-12-34-13-21(15)28-25(20)30-17-4-3-5-18(30)7-6-17/h8-11,17-18H,3-7,12-13H2,1-2H3,(H,27,32)(H,29,31) WIMJBMDGQAVIBL-UHFFFAOYSA-N 75831 2-(8-azabicyclo[3.2.1]octan-8-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 21 Bromodomain-containing protein 4 [58-164] Homo sapiens 6.00 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75831&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 9557161 252653027 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121230 COc1cc(NC(=O)c2cc3c(nc2N2C4CCCC2CC4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C26H28N4O4/c1-14-8-23(31)29-24-19(14)10-16(11-22(24)33-2)27-26(32)20-9-15-12-34-13-21(15)28-25(20)30-17-4-3-5-18(30)7-6-17/h8-11,17-18H,3-7,12-13H2,1-2H3,(H,27,32)(H,29,31) WIMJBMDGQAVIBL-UHFFFAOYSA-N 75831 2-(8-azabicyclo[3.2.1]octan-8-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 21 Bromodomain-containing protein 4 [353-454] Homo sapiens 1400 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75831&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 9557161 252653027 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121231 COc1cc(NC(=O)c2cc3c(nc2N2C[C@H]4CCO[C@H]4C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-5-22(30)28-23-17(13)7-16(8-20(23)32-2)26-25(31)18-6-15-11-33-12-19(15)27-24(18)29-9-14-3-4-34-21(14)10-29/h5-8,14,21H,3-4,9-12H2,1-2H3,(H,26,31)(H,28,30) RRQUPGQMFPDMDK-UHFFFAOYSA-N 75832 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[rac-(3aR,6aR)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 22 Bromodomain-containing protein 4 [58-164] Homo sapiens 170 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75832&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 1916821 252653028 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121232 COc1cc(NC(=O)c2cc3c(nc2N2C[C@H]4CCO[C@H]4C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O5/c1-13-5-22(30)28-23-17(13)7-16(8-20(23)32-2)26-25(31)18-6-15-11-33-12-19(15)27-24(18)29-9-14-3-4-34-21(14)10-29/h5-8,14,21H,3-4,9-12H2,1-2H3,(H,26,31)(H,28,30) RRQUPGQMFPDMDK-UHFFFAOYSA-N 75832 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[rac-(3aR,6aR)-2,3,3a,4,6,6a-hexahydrofuro[2,3-c]pyrrol-5-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 22 Bromodomain-containing protein 4 [353-454] Homo sapiens 3800 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75832 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75832&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 1916821 252653028 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121233 COc1cc(NC(=O)c2cc3c(nc2N2C[C@@H]4C[C@H]2CO4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H24N4O5/c1-12-3-21(29)27-22-17(12)5-14(6-20(22)31-2)25-24(30)18-4-13-9-32-11-19(13)26-23(18)28-8-16-7-15(28)10-33-16/h3-6,15-16H,7-11H2,1-2H3,(H,25,30)(H,27,29) LEUIJVKZBSZFIC-UHFFFAOYSA-N 75833 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 23 Bromodomain-containing protein 4 [58-164] Homo sapiens 190 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75833 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75833&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 1924960 252653029 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121234 COc1cc(NC(=O)c2cc3c(nc2N2C[C@@H]4C[C@H]2CO4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H24N4O5/c1-12-3-21(29)27-22-17(12)5-14(6-20(22)31-2)25-24(30)18-4-13-9-32-11-19(13)26-23(18)28-8-16-7-15(28)10-33-16/h3-6,15-16H,7-11H2,1-2H3,(H,25,30)(H,27,29) LEUIJVKZBSZFIC-UHFFFAOYSA-N 75833 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 23 Bromodomain-containing protein 4 [353-454] Homo sapiens 3200 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75833 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75833&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 1924960 252653029 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121235 COc1cc(NC(=O)c2cc3c(nc2N2C[C@H]4C[C@@H]2CO4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H24N4O5/c1-12-3-21(29)27-22-17(12)5-14(6-20(22)31-2)25-24(30)18-4-13-9-32-11-19(13)26-23(18)28-8-16-7-15(28)10-33-16/h3-6,15-16H,7-11H2,1-2H3,(H,25,30)(H,27,29) LEUIJVKZBSZFIC-UHFFFAOYSA-N 75834 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 24 Bromodomain-containing protein 4 [58-164] Homo sapiens 28.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75834&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 5953071 252653030 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121236 COc1cc(NC(=O)c2cc3c(nc2N2C[C@H]4C[C@@H]2CO4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H24N4O5/c1-12-3-21(29)27-22-17(12)5-14(6-20(22)31-2)25-24(30)18-4-13-9-32-11-19(13)26-23(18)28-8-16-7-15(28)10-33-16/h3-6,15-16H,7-11H2,1-2H3,(H,25,30)(H,27,29) LEUIJVKZBSZFIC-UHFFFAOYSA-N 75834 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 24 Bromodomain-containing protein 4 [353-454] Homo sapiens 700 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75834&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 5953071 252653030 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121237 COc1cc(NC(=O)c2cc3c(nc2N2C[C@H]4C[C@@H]2CO4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H24N4O5/c1-12-3-21(29)27-22-17(12)5-14(6-20(22)31-2)25-24(30)18-4-13-9-32-11-19(13)26-23(18)28-8-16-7-15(28)10-33-16/h3-6,15-16H,7-11H2,1-2H3,(H,25,30)(H,27,29) LEUIJVKZBSZFIC-UHFFFAOYSA-N 75834 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 24 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75834 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75834&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 5953071 252653030 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121238 COc1cc(NC(=O)c2cc3c(nc2N2CCC[C@@H]2C)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-13-7-21(29)27-22-17(13)9-16(10-20(22)31-3)25-24(30)18-8-15-11-32-12-19(15)26-23(18)28-6-4-5-14(28)2/h7-10,14H,4-6,11-12H2,1-3H3,(H,25,30)(H,27,29) NNILHNCBNHPDLZ-UHFFFAOYSA-N 75836 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(2S)-2-methylpyrrolidin-1-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 25 Bromodomain-containing protein 4 [58-164] Homo sapiens 150 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75836&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 16446044 252653032 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121239 COc1cc(NC(=O)c2cc3c(nc2N2CCC[C@@H]2C)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-13-7-21(29)27-22-17(13)9-16(10-20(22)31-3)25-24(30)18-8-15-11-32-12-19(15)26-23(18)28-6-4-5-14(28)2/h7-10,14H,4-6,11-12H2,1-3H3,(H,25,30)(H,27,29) NNILHNCBNHPDLZ-UHFFFAOYSA-N 75836 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[(2S)-2-methylpyrrolidin-1-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 25 Bromodomain-containing protein 4 [353-454] Homo sapiens 4500 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75836&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 16446044 252653032 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121240 COc1cc(NC(=O)c2cc3c(nc2N(C)CC2CC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-13-6-21(29)27-22-17(13)8-16(9-20(22)31-3)25-24(30)18-7-15-11-32-12-19(15)26-23(18)28(2)10-14-4-5-14/h6-9,14H,4-5,10-12H2,1-3H3,(H,25,30)(H,27,29) XQFPSLBAQQONQX-UHFFFAOYSA-N 75837 2-[cyclopropylmethyl(methyl)amino]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 26 Bromodomain-containing protein 4 [58-164] Homo sapiens 51.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75837&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2823686 252653033 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121241 COc1cc(NC(=O)c2cc3c(nc2N(C)CC2CC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-13-6-21(29)27-22-17(13)8-16(9-20(22)31-3)25-24(30)18-7-15-11-32-12-19(15)26-23(18)28(2)10-14-4-5-14/h6-9,14H,4-5,10-12H2,1-3H3,(H,25,30)(H,27,29) XQFPSLBAQQONQX-UHFFFAOYSA-N 75837 2-[cyclopropylmethyl(methyl)amino]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 26 Bromodomain-containing protein 4 [353-454] Homo sapiens 3100 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75837&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2823686 252653033 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121242 COc1cc(NC(=O)c2cc3c(nc2N(C)CC2CC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-13-6-21(29)27-22-17(13)8-16(9-20(22)31-3)25-24(30)18-7-15-11-32-12-19(15)26-23(18)28(2)10-14-4-5-14/h6-9,14H,4-5,10-12H2,1-3H3,(H,25,30)(H,27,29) XQFPSLBAQQONQX-UHFFFAOYSA-N 75837 2-[cyclopropylmethyl(methyl)amino]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 26 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75837&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 2823686 252653033 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121243 CCN(CC)c1nc2c(cc1C(=O)Nc1cc(OC)c3[nH]c(=O)cc(C)c3c1)COC2 InChI=1S/C23H26N4O4/c1-5-27(6-2)22-17(8-14-11-31-12-18(14)25-22)23(29)24-15-9-16-13(3)7-20(28)26-21(16)19(10-15)30-4/h7-10H,5-6,11-12H2,1-4H3,(H,24,29)(H,26,28) YZOXVOPKMFEDFF-UHFFFAOYSA-N 75838 2-(diethylamino)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 27 Bromodomain-containing protein 4 [58-164] Homo sapiens 25.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75838&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 6473691 252653034 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121244 CCN(CC)c1nc2c(cc1C(=O)Nc1cc(OC)c3[nH]c(=O)cc(C)c3c1)COC2 InChI=1S/C23H26N4O4/c1-5-27(6-2)22-17(8-14-11-31-12-18(14)25-22)23(29)24-15-9-16-13(3)7-20(28)26-21(16)19(10-15)30-4/h7-10H,5-6,11-12H2,1-4H3,(H,24,29)(H,26,28) YZOXVOPKMFEDFF-UHFFFAOYSA-N 75838 2-(diethylamino)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 27 Bromodomain-containing protein 4 [353-454] Homo sapiens 600 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75838&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 6473691 252653034 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121245 CCN(CC)c1nc2c(cc1C(=O)Nc1cc(OC)c3[nH]c(=O)cc(C)c3c1)COC2 InChI=1S/C23H26N4O4/c1-5-27(6-2)22-17(8-14-11-31-12-18(14)25-22)23(29)24-15-9-16-13(3)7-20(28)26-21(16)19(10-15)30-4/h7-10H,5-6,11-12H2,1-4H3,(H,24,29)(H,26,28) YZOXVOPKMFEDFF-UHFFFAOYSA-N 75838 2-(diethylamino)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 27 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75838 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75838&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 6473691 252653034 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121246 CCN(c1nc2c(cc1C(=O)Nc1cc(OC)c3[nH]c(=O)cc(C)c3c1)COC2)C(C)C InChI=1S/C24H28N4O4/c1-6-28(13(2)3)23-18(8-15-11-32-12-19(15)26-23)24(30)25-16-9-17-14(4)7-21(29)27-22(17)20(10-16)31-5/h7-10,13H,6,11-12H2,1-5H3,(H,25,30)(H,27,29) UDBYQLZEJSXLGC-UHFFFAOYSA-N 75841 2-[ethyl(isopropyl)amino]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 28 Bromodomain-containing protein 4 [58-164] Homo sapiens 33.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75841&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 16664653 252653037 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121247 CCN(c1nc2c(cc1C(=O)Nc1cc(OC)c3[nH]c(=O)cc(C)c3c1)COC2)C(C)C InChI=1S/C24H28N4O4/c1-6-28(13(2)3)23-18(8-15-11-32-12-19(15)26-23)24(30)25-16-9-17-14(4)7-21(29)27-22(17)20(10-16)31-5/h7-10,13H,6,11-12H2,1-5H3,(H,25,30)(H,27,29) UDBYQLZEJSXLGC-UHFFFAOYSA-N 75841 2-[ethyl(isopropyl)amino]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 28 Bromodomain-containing protein 4 [353-454] Homo sapiens 1000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75841&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 16664653 252653037 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121248 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CCC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-14-10-21(29)27-22-17(14)12-16(13-20(22)31-2)25-24(30)18-11-15-4-3-5-19(15)26-23(18)28-6-8-32-9-7-28/h10-13H,3-9H2,1-2H3,(H,25,30)(H,27,29) ZJWIFSSCSITXCS-UHFFFAOYSA-N 75842 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamide::US20250382308, Example 29 Bromodomain-containing protein 4 [58-164] Homo sapiens 18.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75842&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2921884 252653038 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121249 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CCC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-14-10-21(29)27-22-17(14)12-16(13-20(22)31-2)25-24(30)18-11-15-4-3-5-19(15)26-23(18)28-6-8-32-9-7-28/h10-13H,3-9H2,1-2H3,(H,25,30)(H,27,29) ZJWIFSSCSITXCS-UHFFFAOYSA-N 75842 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamide::US20250382308, Example 29 Bromodomain-containing protein 4 [353-454] Homo sapiens 1900 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75842&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2921884 252653038 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121250 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CCC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O4/c1-14-10-21(29)27-22-17(14)12-16(13-20(22)31-2)25-24(30)18-11-15-4-3-5-19(15)26-23(18)28-6-8-32-9-7-28/h10-13H,3-9H2,1-2H3,(H,25,30)(H,27,29) ZJWIFSSCSITXCS-UHFFFAOYSA-N 75842 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carboxamide::US20250382308, Example 29 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75842&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 2921884 252653038 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121251 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CO[C@@H]3C)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O5/c1-13-8-21(29)27-22-16(13)9-15(10-20(22)31-3)25-24(30)18-11-17-14(2)33-12-19(17)26-23(18)28-4-6-32-7-5-28/h8-11,14H,4-7,12H2,1-3H3,(H,25,30)(H,27,29) JDEHHZPDRHILFL-UHFFFAOYSA-N 75843 (5R)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5-methyl-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 30 Bromodomain-containing protein 4 [58-164] Homo sapiens 14.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75843&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 7783431 252653039 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121252 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CO[C@@H]3C)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O5/c1-13-8-21(29)27-22-16(13)9-15(10-20(22)31-3)25-24(30)18-11-17-14(2)33-12-19(17)26-23(18)28-4-6-32-7-5-28/h8-11,14H,4-7,12H2,1-3H3,(H,25,30)(H,27,29) JDEHHZPDRHILFL-UHFFFAOYSA-N 75843 (5R)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5-methyl-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 30 Bromodomain-containing protein 4 [353-454] Homo sapiens 1200 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75843&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 7783431 252653039 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121253 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3C)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O5/c1-13-8-21(29)27-22-16(13)9-15(10-20(22)31-3)25-24(30)18-11-17-14(2)33-12-19(17)26-23(18)28-4-6-32-7-5-28/h8-11,14H,4-7,12H2,1-3H3,(H,25,30)(H,27,29) JDEHHZPDRHILFL-UHFFFAOYSA-N 75844 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5-methyl-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 31 Bromodomain-containing protein 4 [58-164] Homo sapiens 22.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75844 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75844&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 2389630 252653040 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121254 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3C)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H26N4O5/c1-13-8-21(29)27-22-16(13)9-15(10-20(22)31-3)25-24(30)18-11-17-14(2)33-12-19(17)26-23(18)28-4-6-32-7-5-28/h8-11,14H,4-7,12H2,1-3H3,(H,25,30)(H,27,29) JDEHHZPDRHILFL-UHFFFAOYSA-N 75844 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5-methyl-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 31 Bromodomain-containing protein 4 [353-454] Homo sapiens 1000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75844 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75844&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 2389630 252653040 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121255 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CN(C)C3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H27N5O4/c1-14-8-21(30)27-22-17(14)10-16(11-20(22)32-3)25-24(31)18-9-15-12-28(2)13-19(15)26-23(18)29-4-6-33-7-5-29/h8-11H,4-7,12-13H2,1-3H3,(H,25,31)(H,27,30) BNWDKUKDABQINT-UHFFFAOYSA-N 75845 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-6-methyl-2-morpholino-5,7-dihydropyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 32 Bromodomain-containing protein 4 [58-164] Homo sapiens 17.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75845 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75845&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 24789424 252653041 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121256 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CN(C)C3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C24H27N5O4/c1-14-8-21(30)27-22-17(14)10-16(11-20(22)32-3)25-24(31)18-9-15-12-28(2)13-19(15)26-23(18)29-4-6-33-7-5-29/h8-11H,4-7,12-13H2,1-3H3,(H,25,31)(H,27,30) BNWDKUKDABQINT-UHFFFAOYSA-N 75845 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-6-methyl-2-morpholino-5,7-dihydropyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 32 Bromodomain-containing protein 4 [353-454] Homo sapiens 300 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75845 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75845&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 24789424 252653041 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121257 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CN(C2COC2)C3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C26H29N5O5/c1-15-7-23(32)29-24-19(15)9-17(10-22(24)34-2)27-26(33)20-8-16-11-31(18-13-36-14-18)12-21(16)28-25(20)30-3-5-35-6-4-30/h7-10,18H,3-6,11-14H2,1-2H3,(H,27,33)(H,29,32) PYGXDQJXLXLNBL-UHFFFAOYSA-N 75846 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-6-(oxetan-3-yl)-5,7-dihydropyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 33 Bromodomain-containing protein 4 [58-164] Homo sapiens 13.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75846 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75846&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 4327876 242053603 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121258 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CN(C2COC2)C3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C26H29N5O5/c1-15-7-23(32)29-24-19(15)9-17(10-22(24)34-2)27-26(33)20-8-16-11-31(18-13-36-14-18)12-21(16)28-25(20)30-3-5-35-6-4-30/h7-10,18H,3-6,11-14H2,1-2H3,(H,27,33)(H,29,32) PYGXDQJXLXLNBL-UHFFFAOYSA-N 75846 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-6-(oxetan-3-yl)-5,7-dihydropyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 33 Bromodomain-containing protein 4 [353-454] Homo sapiens 300 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75846 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75846&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 4327876 242053603 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121259 CCN1Cc2cc(C(=O)Nc3cc(OC)c4[nH]c(=O)cc(C)c4c3)c(N3CCOCC3)nc2C1 InChI=1S/C25H29N5O4/c1-4-29-13-16-10-19(24(27-20(16)14-29)30-5-7-34-8-6-30)25(32)26-17-11-18-15(2)9-22(31)28-23(18)21(12-17)33-3/h9-12H,4-8,13-14H2,1-3H3,(H,26,32)(H,28,31) OTJBHNJXONUVEU-UHFFFAOYSA-N 75847 6-ethyl-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydropyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 34 Bromodomain-containing protein 4 [58-164] Homo sapiens 25.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75847 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75847&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 4910088 252653042 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121260 CCN1Cc2cc(C(=O)Nc3cc(OC)c4[nH]c(=O)cc(C)c4c3)c(N3CCOCC3)nc2C1 InChI=1S/C25H29N5O4/c1-4-29-13-16-10-19(24(27-20(16)14-29)30-5-7-34-8-6-30)25(32)26-17-11-18-15(2)9-22(31)28-23(18)21(12-17)33-3/h9-12H,4-8,13-14H2,1-3H3,(H,26,32)(H,28,31) OTJBHNJXONUVEU-UHFFFAOYSA-N 75847 6-ethyl-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydropyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 34 Bromodomain-containing protein 4 [353-454] Homo sapiens 800 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75847 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75847&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 4910088 252653042 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121261 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CN(C(C)C)C3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C26H31N5O4/c1-15(2)31-13-17-10-20(25(28-21(17)14-31)30-5-7-35-8-6-30)26(33)27-18-11-19-16(3)9-23(32)29-24(19)22(12-18)34-4/h9-12,15H,5-8,13-14H2,1-4H3,(H,27,33)(H,29,32) GQWOUZSKLMOQDX-UHFFFAOYSA-N 75848 6-isopropyl-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydropyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 35 Bromodomain-containing protein 4 [58-164] Homo sapiens 20.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75848&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 4869155 252653043 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121262 COc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)CN(C(C)C)C3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C26H31N5O4/c1-15(2)31-13-17-10-20(25(28-21(17)14-31)30-5-7-35-8-6-30)26(33)27-18-11-19-16(3)9-23(32)29-24(19)22(12-18)34-4/h9-12,15H,5-8,13-14H2,1-4H3,(H,27,33)(H,29,32) GQWOUZSKLMOQDX-UHFFFAOYSA-N 75848 6-isopropyl-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-morpholino-5,7-dihydropyrrolo[3,4-b]pyridine-3-carboxamide::US20250382308, Example 35 Bromodomain-containing protein 4 [353-454] Homo sapiens 600 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75848&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 4869155 252653043 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121263 Cc1cc(=O)[nH]c2c(OCCO)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C24H26N4O6/c1-14-8-21(30)27-22-17(14)10-16(11-20(22)34-7-4-29)25-24(31)18-9-15-12-33-13-19(15)26-23(18)28-2-5-32-6-3-28/h8-11,29H,2-7,12-13H2,1H3,(H,25,31)(H,27,30) MXPMTLSQGSBWTK-UHFFFAOYSA-N 75849 N-[8-(2-hydroxyethoxy)-4-methyl-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 36 Bromodomain-containing protein 4 [58-164] Homo sapiens 27.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75849&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 4973506 252653044 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121264 Cc1cc(=O)[nH]c2c(OCCO)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C24H26N4O6/c1-14-8-21(30)27-22-17(14)10-16(11-20(22)34-7-4-29)25-24(31)18-9-15-12-33-13-19(15)26-23(18)28-2-5-32-6-3-28/h8-11,29H,2-7,12-13H2,1H3,(H,25,31)(H,27,30) MXPMTLSQGSBWTK-UHFFFAOYSA-N 75849 N-[8-(2-hydroxyethoxy)-4-methyl-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 36 Bromodomain-containing protein 4 [353-454] Homo sapiens 400 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75849&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 4973506 252653044 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121265 Cc1cc(=O)[nH]c2c(OCCO)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C24H26N4O6/c1-14-8-21(30)27-22-17(14)10-16(11-20(22)34-7-4-29)25-24(31)18-9-15-12-33-13-19(15)26-23(18)28-2-5-32-6-3-28/h8-11,29H,2-7,12-13H2,1H3,(H,25,31)(H,27,30) MXPMTLSQGSBWTK-UHFFFAOYSA-N 75849 N-[8-(2-hydroxyethoxy)-4-methyl-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 36 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75849&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 4973506 252653044 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 121266 Cc1cc(=O)[nH]c2c(OC3CNC3)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C25H27N5O5/c1-14-6-22(31)29-23-18(14)8-16(9-21(23)35-17-10-26-11-17)27-25(32)19-7-15-12-34-13-20(15)28-24(19)30-2-4-33-5-3-30/h6-9,17,26H,2-5,10-13H2,1H3,(H,27,32)(H,29,31) OZTDBPLHNCLZCC-UHFFFAOYSA-N 75850 N-[8-(azetidin-3-yloxy)-4-methyl-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 37 Bromodomain-containing protein 4 [58-164] Homo sapiens 35.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75850&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 24981522 252653045 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121267 Cc1cc(=O)[nH]c2c(OC3CNC3)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C25H27N5O5/c1-14-6-22(31)29-23-18(14)8-16(9-21(23)35-17-10-26-11-17)27-25(32)19-7-15-12-34-13-20(15)28-24(19)30-2-4-33-5-3-30/h6-9,17,26H,2-5,10-13H2,1H3,(H,27,32)(H,29,31) OZTDBPLHNCLZCC-UHFFFAOYSA-N 75850 N-[8-(azetidin-3-yloxy)-4-methyl-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 37 Bromodomain-containing protein 4 [353-454] Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75850&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 24981522 252653045 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 121268 Cc1cc(=O)[nH]c2c(OC3CNC3)cc(NC(=O)c3cc4c(nc3N3CCOCC3)COC4)cc12 InChI=1S/C25H27N5O5/c1-14-6-22(31)29-23-18(14)8-16(9-21(23)35-17-10-26-11-17)27-25(32)19-7-15-12-34-13-20(15)28-24(19)30-2-4-33-5-3-30/h6-9,17,26H,2-5,10-13H2,1H3,(H,27,32)(H,29,31) OZTDBPLHNCLZCC-UHFFFAOYSA-N 75850 N-[8-(azetidin-3-yloxy)-4-methyl-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 37 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75850&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 24981522 252653045 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 122150 CNCCOc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H29N5O5/c1-15-9-22(31)29-23-18(15)11-17(12-21(23)35-6-3-26-2)27-25(32)19-10-16-13-34-14-20(16)28-24(19)30-4-7-33-8-5-30/h9-12,26H,3-8,13-14H2,1-2H3,(H,27,32)(H,29,31) VYMBOBPTKPPPKQ-UHFFFAOYSA-N 75851 N-[4-methyl-8-[2-(methylamino)ethoxy]-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 38 Bromodomain-containing protein 4 [58-164] Homo sapiens 20.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75851&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 16284831 252653046 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122151 CNCCOc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H29N5O5/c1-15-9-22(31)29-23-18(15)11-17(12-21(23)35-6-3-26-2)27-25(32)19-10-16-13-34-14-20(16)28-24(19)30-4-7-33-8-5-30/h9-12,26H,3-8,13-14H2,1-2H3,(H,27,32)(H,29,31) VYMBOBPTKPPPKQ-UHFFFAOYSA-N 75851 N-[4-methyl-8-[2-(methylamino)ethoxy]-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 38 Bromodomain-containing protein 4 [353-454] Homo sapiens >5000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75851&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 16284831 252653046 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122152 CNCCOc1cc(NC(=O)c2cc3c(nc2N2CCOCC2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H29N5O5/c1-15-9-22(31)29-23-18(15)11-17(12-21(23)35-6-3-26-2)27-25(32)19-10-16-13-34-14-20(16)28-24(19)30-4-7-33-8-5-30/h9-12,26H,3-8,13-14H2,1-2H3,(H,27,32)(H,29,31) VYMBOBPTKPPPKQ-UHFFFAOYSA-N 75851 N-[4-methyl-8-[2-(methylamino)ethoxy]-2-oxo-1H-quinolin-6-yl]-2-morpholino-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 38 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75851&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 16284831 252653046 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 122153 COc1cc(NC(=O)c2cc3c(nc2N2C4CCC2CC4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O4/c1-13-7-22(30)28-23-18(13)9-15(10-21(23)32-2)26-25(31)19-8-14-11-33-12-20(14)27-24(19)29-16-3-4-17(29)6-5-16/h7-10,16-17H,3-6,11-12H2,1-2H3,(H,26,31)(H,28,30) MFWWKWDPVGXYAL-UHFFFAOYSA-N 75852 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 39 Bromodomain-containing protein 4 [58-164] Homo sapiens 7.00 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75852&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 9508973 252653047 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122154 COc1cc(NC(=O)c2cc3c(nc2N2C4CCC2CC4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O4/c1-13-7-22(30)28-23-18(13)9-15(10-21(23)32-2)26-25(31)19-8-14-11-33-12-20(14)27-24(19)29-16-3-4-17(29)6-5-16/h7-10,16-17H,3-6,11-12H2,1-2H3,(H,26,31)(H,28,30) MFWWKWDPVGXYAL-UHFFFAOYSA-N 75852 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 39 Bromodomain-containing protein 4 [353-454] Homo sapiens 300 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75852&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 9508973 252653047 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122155 COc1cc(NC(=O)c2cc3c(nc2N2C4CCC2CC4)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C25H26N4O4/c1-13-7-22(30)28-23-18(13)9-15(10-21(23)32-2)26-25(31)19-8-14-11-33-12-20(14)27-24(19)29-16-3-4-17(29)6-5-16/h7-10,16-17H,3-6,11-12H2,1-2H3,(H,26,31)(H,28,30) MFWWKWDPVGXYAL-UHFFFAOYSA-N 75852 2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 39 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75852&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 9508973 252653047 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 122162 COc1cc(NC(=O)c2cc3c(nc2N2CC[C@@H](F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H23FN4O4/c1-12-5-20(29)27-21-16(12)7-15(8-19(21)31-2)25-23(30)17-6-13-10-32-11-18(13)26-22(17)28-4-3-14(24)9-28/h5-8,14H,3-4,9-11H2,1-2H3,(H,25,30)(H,27,29) RAJXJAFRLMAYSD-UHFFFAOYSA-N 75853 2-[(3R)-3-fluoropyrrolidin-1-yl]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 40 Bromodomain-containing protein 4 [58-164] Homo sapiens 11.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75853&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 7779508 252653048 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122163 COc1cc(NC(=O)c2cc3c(nc2N2CC[C@@H](F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H23FN4O4/c1-12-5-20(29)27-21-16(12)7-15(8-19(21)31-2)25-23(30)17-6-13-10-32-11-18(13)26-22(17)28-4-3-14(24)9-28/h5-8,14H,3-4,9-11H2,1-2H3,(H,25,30)(H,27,29) RAJXJAFRLMAYSD-UHFFFAOYSA-N 75853 2-[(3R)-3-fluoropyrrolidin-1-yl]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 40 Bromodomain-containing protein 4 [353-454] Homo sapiens 150 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75853&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 7779508 252653048 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122164 COc1cc(NC(=O)c2cc3c(nc2N2CC[C@H](F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H23FN4O4/c1-12-5-20(29)27-21-16(12)7-15(8-19(21)31-2)25-23(30)17-6-13-10-32-11-18(13)26-22(17)28-4-3-14(24)9-28/h5-8,14H,3-4,9-11H2,1-2H3,(H,25,30)(H,27,29) RAJXJAFRLMAYSD-UHFFFAOYSA-N 75854 2-[(3S)-3-fluoropyrrolidin-1-yl]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 41 Bromodomain-containing protein 4 [58-164] Homo sapiens 92.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75854&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 6219814 252653049 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122165 COc1cc(NC(=O)c2cc3c(nc2N2CC[C@H](F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H23FN4O4/c1-12-5-20(29)27-21-16(12)7-15(8-19(21)31-2)25-23(30)17-6-13-10-32-11-18(13)26-22(17)28-4-3-14(24)9-28/h5-8,14H,3-4,9-11H2,1-2H3,(H,25,30)(H,27,29) RAJXJAFRLMAYSD-UHFFFAOYSA-N 75854 2-[(3S)-3-fluoropyrrolidin-1-yl]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 41 Bromodomain-containing protein 4 [353-454] Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75854&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 6219814 252653049 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122166 COc1cc(NC(=O)c2cc3c(nc2N2CC[C@H](F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H23FN4O4/c1-12-5-20(29)27-21-16(12)7-15(8-19(21)31-2)25-23(30)17-6-13-10-32-11-18(13)26-22(17)28-4-3-14(24)9-28/h5-8,14H,3-4,9-11H2,1-2H3,(H,25,30)(H,27,29) RAJXJAFRLMAYSD-UHFFFAOYSA-N 75854 2-[(3S)-3-fluoropyrrolidin-1-yl]-N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 41 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75854&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 6219814 252653049 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1 122167 COc1cc(NC(=O)c2cc3c(nc2N2C[C@@H](F)[C@@H](F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H22F2N4O4/c1-11-3-20(30)28-21-14(11)5-13(6-19(21)32-2)26-23(31)15-4-12-9-33-10-18(12)27-22(15)29-7-16(24)17(25)8-29/h3-6,16-17H,7-10H2,1-2H3,(H,26,31)(H,28,30) FCZDUHXOHJIXIR-UHFFFAOYSA-N 75855 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[rac-(3R,4S)-3,4-difluoropyrrolidin-1-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 42 Bromodomain-containing protein 4 [58-164] Homo sapiens 26.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75855&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 44144203 252653050 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122168 COc1cc(NC(=O)c2cc3c(nc2N2C[C@@H](F)[C@@H](F)C2)COC3)cc2c(C)cc(=O)[nH]c12 InChI=1S/C23H22F2N4O4/c1-11-3-20(30)28-21-14(11)5-13(6-19(21)32-2)26-23(31)15-4-12-9-33-10-18(12)27-22(15)29-7-16(24)17(25)8-29/h3-6,16-17H,7-10H2,1-2H3,(H,26,31)(H,28,30) FCZDUHXOHJIXIR-UHFFFAOYSA-N 75855 N-(8-methoxy-4-methyl-2-oxo-1H-quinolin-6-yl)-2-[rac-(3R,4S)-3,4-difluoropyrrolidin-1-yl]-5,7-dihydrofuro[3,4-b]pyridine-3-carboxamide::US20250382308, Example 42 Bromodomain-containing protein 4 [353-454] Homo sapiens 400 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75855&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 44144203 252653050 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122169 COC1C=C(NC(=O)C2C=C3COCC3=NC2N2C[C@H](F)[C@@H](F)C2)C=C2C(C)=CC(=O)NC21 InChI=1S/C23H26F2N4O4/c1-11-3-20(30)28-21-14(11)5-13(6-19(21)32-2)26-23(31)15-4-12-9-33-10-18(12)27-22(15)29-7-16(24)17(25)8-29/h3-6,15-17,19,21-22H,7-10H2,1-2H3,(H,26,31)(H,28,30) HSKOBVPWCCDGEI-UHFFFAOYSA-N 75856 US20250382308, Example 43 Bromodomain-containing protein 4 [58-164] Homo sapiens 18.0 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1168&target=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75856&enzyme=Bromodomain-containing+protein+4+%5B58-164%5D&column=ki&startPg=0&Increment=50&submit=Search 7834111 252653051 1 RQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL 4BJX,4UYD,9C5V,7FH2,6IN1,6AJZ,6AJY,6AJX,6AJW,6AJV,5YQX,7KHL,7KHH,5VOM,6ZCI,5Y8C,9NN5,8ZMB,8ZM8,8WY7,8WY3,8WXY,8K14,7YL2,7WL4,7WKY,7WJS,7V2J,7V1U,7DHS,5Z1T,5Z1S,5Z1R,5Y94,5Y93,5Y8Z,5Y8Y,5Y8W,5D0C,5CY9,5CTL,5CS8,5CRZ,5CRM,5CQT,5CPE,5CP5,5COI,6VIZ,6VIW,9MPI,6DNE,7TV0,7TUQ,5U2F,5U2E,4KV1,9NNT,9MXK,6MAU,6E4A,6CZV,6CZU,5DW2,4YH4,4YH3,5U28,8Q34,6X7C,6X7B,6ULV,6ULS,6U8M,6U8G,6U74,6U72,6U6K,9RSD,9RSC,6DJC,6X7D,6WW8,4ZW1,5KU3,5I88,5I80,4DON,5HM0,5HLS,4LRG,4LR6,4Z1Q,6DL2,4Z1S,4X2I,3MUL,3MUK,3JVK,3JVJ,6CD4,5WA5,5W55,7WWZ,6VUJ,6VUF,6VUC,6VUB,6PSB,6PS9,6PRT,9ZG4,6CJ2,6CJ1,6CIS,5HQ6,4QR5,4QR4,4QR3,8YMI,8YMH,8YMG,8YMF,8YME,6WVX,8OV6,4C66,9SAI,9SAF,9R5N,9QW8,9QNV,9IV5,9HT2,9HT1,9HT0,9FXP,9FWX,9FBY,9F1N,9F1M,9F1L,9F1K,8V9F,8V92,8QAR,8QAP,8QAN,8QAL,8PXN,8PXM,8PXA,8PIQ,8P9L,8P9K,8P9J,8P9I,8P9H,8P9G,8P9F,8FVK,8EWV,8EAD,8E3W,8E17,8DYR,8BEB,8BDS,8B98,8B96,7UTY,7UGF,7RXT,7RXS,7RXR,7RN2,7RMD,7RJR,7RJQ,7RJP,7RJO,7REM,7REL,7R9C,7R5B,7QDL,7Q3F,7P6Y,7P6W,7P6V,7O18,7MRB,7MRA,7MR9,7MR8,7MR7,7MR6,7MR5,7MLS,7MLR,7MLQ,7M16,7LH8,7L9M,7K6H,7K6G,7B1T,7AXR,7AJN,7A9U,6ZF9,6ZEL,6ZED,6ZB3,6Z7M,6Z7L,6Z7G,6YQZ,6YQP,6YQO,6YQN,6YIN,6XVC,6XV7,6XV3,6XUZ,6WGX,6V1U,6V1L,6V1K,6V0U,6UWX,6UWU,6UVM,6UVJ,6U0D,6TPZ,6TPY,6TPX,6SWQ,6SWN,6SE4,6SB8,6SAJ,6SAH,6SA3,6SA2,6S6K,6S4B,6S25,6RWJ,6Q3Z,6Q3Y,6MH7,6MH1,6KEG,6KEF,6KEE,6KED,6I7Y,6I7X,6HOV,6HDQ,6G0S,6G0R,6G0Q,6G0P,6G0O,6G0H,6G0G,6G0F,6G0E,6G0D,6FT4,6FT3,6FSY,6FO5,6FNX,6DML,6DMJ,6CIY,6CD5,6BOY,6BNB,6BN9,6BN7,6AFR,5Z9K,5Z90,5Z8Z,5Z8R,5Z8G,5YOV,5YOU,5WMA,5VBP,5VBO,5V67,5ULA,5TI7,5TI6,5TI5,5TI4,5TI3,5TI2,5OWW,5OWM,5OVB,5O97,5NNG,5NNF,5NNE,5NND,5NNC,5N2M,5MLI,5MKZ,5M3A,5M39,5LUU,5LJ2,5LJ1,5KJ0,5KHM,5KDH,5IGK,5HQ5,5HCL,5FBX,5F63,5F62,5F61,5F60,5F5Z,5EIS,5EI4,5EGU,5E0R,5DLZ,5DLX,5D3T,5D3R,5D3P,5D3L,5D26,5CFW,5BT4,5AD3,5AD2,5ACY,5A85,4ZC9,4XYA,4XY9,4WIV,4WHW,4UIZ,4UIY,4QZS,4QB3,4PS5,4PCI,4PCE,4OGJ,4OGI,4O7F,4O7E,4O7C,4O7B,4O7A,4O78,4O77,4O76,4O75,4O74 Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122170 COC1C=C(NC(=O)C2C=C3COCC3=NC2N2C[C@H](F)[C@@H](F)C2)C=C2C(C)=CC(=O)NC21 InChI=1S/C23H26F2N4O4/c1-11-3-20(30)28-21-14(11)5-13(6-19(21)32-2)26-23(31)15-4-12-9-33-10-18(12)27-22(15)29-7-16(24)17(25)8-29/h3-6,15-17,19,21-22H,7-10H2,1-2H3,(H,26,31)(H,28,30) HSKOBVPWCCDGEI-UHFFFAOYSA-N 75856 US20250382308, Example 43 Bromodomain-containing protein 4 [353-454] Homo sapiens 400 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1169&target=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75856&enzyme=Bromodomain-containing+protein+4+%5B353-454%5D&column=ki&startPg=0&Increment=50&submit=Search 7834111 252653051 1 QLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRF 6C7Q,5UOO,6DUV,8RWZ,8RQ9,7ZNT,7RUH,7JKZ,6SIS,5T35,5JWM,2YEM,2OUO,7OEO,6FFD,8YMB,6MNL,2MJV,2LSP,8IDH,7KO0,4Z93,8G46,8BDX,8BDT,7C6P,5UVZ,5UVY,5UVX,5UVV,5UVU,5UVT,5UVS,5UF0,5UEZ,5UEY,5UEX,5UEV,5UEU,5UET,5UES,5UER,5UEQ,5UEP,5UEO,8RX0,6VIX,5U2C,2I8N,9MPD,6U8I,6U6L,4KV4,8CV6,8CV4,6KO2,7USK,7USJ,7AQT,2DWW,8ZMQ,3JVM,3JVL,8OV6,6DNE Bromodomain-containing protein 4 BRD4_HUMAN O60885 O60433 Q4G0X8 Q86YS8 Q96PD3 122171 COC1C=C(NC(=O)C2C=C3COCC3=NC2N2C[C@H](F)[C@@H](F)C2)C=C2C(C)=CC(=O)NC21 InChI=1S/C23H26F2N4O4/c1-11-3-20(30)28-21-14(11)5-13(6-19(21)32-2)26-23(31)15-4-12-9-33-10-18(12)27-22(15)29-7-16(24)17(25)8-29/h3-6,15-17,19,21-22H,7-10H2,1-2H3,(H,26,31)(H,28,30) HSKOBVPWCCDGEI-UHFFFAOYSA-N 75856 US20250382308, Example 43 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A Homo sapiens >10000 US Patent 10.7270/Q2S18792 US20250382308 SMITH, GP; RAST, S; STASI, LP; PEIRO CADAHIA, J; POLJAK, V 12/18/2025 4/29/2026 Nuevolution http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75856 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1570&target=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75856&enzyme=cGMP-inhibited+3%27%2C5%27-cyclic+phosphodiesterase+3A&column=ki&startPg=0&Increment=50&submit=Search 7834111 252653051 1 MAVPGDAARVRDKPVHSGVSQAPTAGRDCHHRADPASPRDSGCRGCWGDLVLQPLRSSRKLSSALCAGSLSFLLALLVRLVRGEVGCDLEQCKEAAAAEEEEAAPGAEGGVFPGPRGGAPGGGARLSPWLQPSALLFSLLCAFFWMGLYLLRAGVRLPLAVALLAACCGGEALVQIGLGVGEDHLLSLPAAGVVLSCLAAATWLVLRLRLGVLMIALTSAVRTVSLISLERFKVAWRPYLAYLAGVLGILLARYVEQILPQSAEAAPREHLGSQLIAGTKEDIPVFKRRRRSSSVVSAEMSGCSSKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRGEEIPTQKPDQ 7LRD,7LRC,7EG4,7EG1,7EG0 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A PDE3A_HUMAN Q14432 O60865 Q13348 Q17RD1