BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 123556 O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31) NYNZQNWKBKUAII-UHFFFAOYSA-N 136597 US8865698, 14::US10047097, 14::US9676783, 14::US10005783, 14::US10774085, Example 14::US11098046, Compound LOXO-101::US11453672, Example L-7::US11267818, Example 14::US12129258, Example LOXO-101::US20250387388, Compound LOXO101(Positive Control) High affinity nerve growth factor receptor Homo sapiens 0.420 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=136597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=136597&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 46188928 249812923 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123557 O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31) NYNZQNWKBKUAII-UHFFFAOYSA-N 136597 US8865698, 14::US10047097, 14::US9676783, 14::US10005783, 14::US10774085, Example 14::US11098046, Compound LOXO-101::US11453672, Example L-7::US11267818, Example 14::US12129258, Example LOXO-101::US20250387388, Compound LOXO101(Positive Control) BDNF/NT-3 growth factors receptor Homo sapiens 1.16 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=136597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=136597&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 46188928 249812923 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123558 O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31) NYNZQNWKBKUAII-UHFFFAOYSA-N 136597 US8865698, 14::US10047097, 14::US9676783, 14::US10005783, 14::US10774085, Example 14::US11098046, Compound LOXO-101::US11453672, Example L-7::US11267818, Example 14::US12129258, Example LOXO-101::US20250387388, Compound LOXO101(Positive Control) NT-3 growth factor receptor Homo sapiens 0.480 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=136597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=136597&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 46188928 249812923 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123559 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(c3nc(N5CCOCC5)cnc3C(=O)c3ncc(N5CCOCC5)nc3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C57H52F2N16O5/c1-3-29-19-45(76)37(58)21-35(29)31-5-7-33-39(17-31)68-70-49(33)54-62-41-25-74(26-42(41)63-54)56-51(60-23-47(66-56)72-9-13-79-14-10-72)53(78)52-57(67-48(24-61-52)73-11-15-80-16-12-73)75-27-43-44(28-75)65-55(64-43)50-34-8-6-32(18-40(34)69-71-50)36-22-38(59)46(77)20-30(36)4-2/h5-8,17-24,76-77H,3-4,9-16,25-28H2,1-2H3,(H,62,63)(H,64,65)(H,68,70)(H,69,71) JCTLYCOOAGBUOU-UHFFFAOYSA-N 75881 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(5-morpholinylpyrazin-2-yl)ketone::US20250387388, Compound MDI-201 High affinity nerve growth factor receptor Homo sapiens 5.76 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75881&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 46172927 252653074 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123560 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(c3nc(N5CCOCC5)cnc3C(=O)c3ncc(N5CCOCC5)nc3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C57H52F2N16O5/c1-3-29-19-45(76)37(58)21-35(29)31-5-7-33-39(17-31)68-70-49(33)54-62-41-25-74(26-42(41)63-54)56-51(60-23-47(66-56)72-9-13-79-14-10-72)53(78)52-57(67-48(24-61-52)73-11-15-80-16-12-73)75-27-43-44(28-75)65-55(64-43)50-34-8-6-32(18-40(34)69-71-50)36-22-38(59)46(77)20-30(36)4-2/h5-8,17-24,76-77H,3-4,9-16,25-28H2,1-2H3,(H,62,63)(H,64,65)(H,68,70)(H,69,71) JCTLYCOOAGBUOU-UHFFFAOYSA-N 75881 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(5-morpholinylpyrazin-2-yl)ketone::US20250387388, Compound MDI-201 BDNF/NT-3 growth factors receptor Homo sapiens 6.14 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75881&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 46172927 252653074 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123561 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(c3nc(N5CCOCC5)cnc3C(=O)c3ncc(N5CCOCC5)nc3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C57H52F2N16O5/c1-3-29-19-45(76)37(58)21-35(29)31-5-7-33-39(17-31)68-70-49(33)54-62-41-25-74(26-42(41)63-54)56-51(60-23-47(66-56)72-9-13-79-14-10-72)53(78)52-57(67-48(24-61-52)73-11-15-80-16-12-73)75-27-43-44(28-75)65-55(64-43)50-34-8-6-32(18-40(34)69-71-50)36-22-38(59)46(77)20-30(36)4-2/h5-8,17-24,76-77H,3-4,9-16,25-28H2,1-2H3,(H,62,63)(H,64,65)(H,68,70)(H,69,71) JCTLYCOOAGBUOU-UHFFFAOYSA-N 75881 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(5-morpholinylpyrazin-2-yl)ketone::US20250387388, Compound MDI-201 NT-3 growth factor receptor Homo sapiens 2.20 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=75881 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=75881&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 46172927 252653074 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123562 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(S(=O)(=O)C3CC3)C4)n[nH]c2c1 InChI=1S/C23H22FN5O3S/c1-2-12-8-21(30)17(24)9-16(12)13-3-6-15-18(7-13)27-28-22(15)23-25-19-10-29(11-20(19)26-23)33(31,32)14-4-5-14/h3,6-9,14,30H,2,4-5,10-11H2,1H3,(H,25,26)(H,27,28) JBBVWBMILLUBTG-UHFFFAOYSA-N 77563 4-(3-(5-(cyclopropanesulfonyl)-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl)-1H-indazol-6-yl)-5-ethyl-2-fluorophenol::US20250387388, Compound MDI-218 High affinity nerve growth factor receptor Homo sapiens 9.97 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77563&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 9635825 252654594 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123563 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(S(=O)(=O)C3CC3)C4)n[nH]c2c1 InChI=1S/C23H22FN5O3S/c1-2-12-8-21(30)17(24)9-16(12)13-3-6-15-18(7-13)27-28-22(15)23-25-19-10-29(11-20(19)26-23)33(31,32)14-4-5-14/h3,6-9,14,30H,2,4-5,10-11H2,1H3,(H,25,26)(H,27,28) JBBVWBMILLUBTG-UHFFFAOYSA-N 77563 4-(3-(5-(cyclopropanesulfonyl)-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl)-1H-indazol-6-yl)-5-ethyl-2-fluorophenol::US20250387388, Compound MDI-218 BDNF/NT-3 growth factors receptor Homo sapiens 32.3 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77563&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 9635825 252654594 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123564 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(S(=O)(=O)C3CC3)C4)n[nH]c2c1 InChI=1S/C23H22FN5O3S/c1-2-12-8-21(30)17(24)9-16(12)13-3-6-15-18(7-13)27-28-22(15)23-25-19-10-29(11-20(19)26-23)33(31,32)14-4-5-14/h3,6-9,14,30H,2,4-5,10-11H2,1H3,(H,25,26)(H,27,28) JBBVWBMILLUBTG-UHFFFAOYSA-N 77563 4-(3-(5-(cyclopropanesulfonyl)-1,4,5,6-tetrahydropyrrolo[3,4-d]imidazol-2-yl)-1H-indazol-6-yl)-5-ethyl-2-fluorophenol::US20250387388, Compound MDI-218 NT-3 growth factor receptor Homo sapiens 5.10 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77563&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 9635825 252654594 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123565 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(C)CCN3C(=O)N3CCN(C)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H54F2N14O3/c1-5-27-17-43(68)35(52)19-33(27)29-7-9-31-37(15-29)58-60-47(31)49-54-39-21-64(22-40(39)55-49)45-25-62(3)11-13-66(45)51(70)67-14-12-63(4)26-46(67)65-23-41-42(24-65)57-50(56-41)48-32-10-8-30(16-38(32)59-61-48)34-20-36(53)44(69)18-28(34)6-2/h7-10,15-20,45-46,68-69H,5-6,11-14,21-26H2,1-4H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) DQQXGBLWMGYGAL-UHFFFAOYSA-N 77565 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-methylpiperazin-1-yl)ketone::US20250387388, Compound MDI-235 High affinity nerve growth factor receptor Homo sapiens 0.570 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77565&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898205 252654596 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123566 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(C)CCN3C(=O)N3CCN(C)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H54F2N14O3/c1-5-27-17-43(68)35(52)19-33(27)29-7-9-31-37(15-29)58-60-47(31)49-54-39-21-64(22-40(39)55-49)45-25-62(3)11-13-66(45)51(70)67-14-12-63(4)26-46(67)65-23-41-42(24-65)57-50(56-41)48-32-10-8-30(16-38(32)59-61-48)34-20-36(53)44(69)18-28(34)6-2/h7-10,15-20,45-46,68-69H,5-6,11-14,21-26H2,1-4H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) DQQXGBLWMGYGAL-UHFFFAOYSA-N 77565 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-methylpiperazin-1-yl)ketone::US20250387388, Compound MDI-235 BDNF/NT-3 growth factors receptor Homo sapiens 1.39 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77565&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898205 252654596 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123567 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(C)CCN3C(=O)N3CCN(C)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H54F2N14O3/c1-5-27-17-43(68)35(52)19-33(27)29-7-9-31-37(15-29)58-60-47(31)49-54-39-21-64(22-40(39)55-49)45-25-62(3)11-13-66(45)51(70)67-14-12-63(4)26-46(67)65-23-41-42(24-65)57-50(56-41)48-32-10-8-30(16-38(32)59-61-48)34-20-36(53)44(69)18-28(34)6-2/h7-10,15-20,45-46,68-69H,5-6,11-14,21-26H2,1-4H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) DQQXGBLWMGYGAL-UHFFFAOYSA-N 77565 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-methylpiperazin-1-yl)ketone::US20250387388, Compound MDI-235 NT-3 growth factor receptor Homo sapiens 0.270 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77565&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898205 252654596 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123568 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CC(O)CCN3C(=O)N3CCC(O)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H52F2N12O5/c1-3-25-15-43(68)35(52)19-33(25)27-5-7-31-37(13-27)58-60-47(31)49-54-39-21-62(22-40(39)55-49)45-17-29(66)9-11-64(45)51(70)65-12-10-30(67)18-46(65)63-23-41-42(24-63)57-50(56-41)48-32-8-6-28(14-38(32)59-61-48)34-20-36(53)44(69)16-26(34)4-2/h5-8,13-16,19-20,29-30,45-46,66-69H,3-4,9-12,17-18,21-24H2,1-2H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) KWXFTQMTNSFIML-UHFFFAOYSA-N 77566 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-hydroxylpiperidin-1-yl)ketone::US20250387388, Compound MDI-245 High affinity nerve growth factor receptor Homo sapiens 0.830 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77566&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898206 252654597 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123569 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CC(O)CCN3C(=O)N3CCC(O)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H52F2N12O5/c1-3-25-15-43(68)35(52)19-33(25)27-5-7-31-37(13-27)58-60-47(31)49-54-39-21-62(22-40(39)55-49)45-17-29(66)9-11-64(45)51(70)65-12-10-30(67)18-46(65)63-23-41-42(24-63)57-50(56-41)48-32-8-6-28(14-38(32)59-61-48)34-20-36(53)44(69)16-26(34)4-2/h5-8,13-16,19-20,29-30,45-46,66-69H,3-4,9-12,17-18,21-24H2,1-2H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) KWXFTQMTNSFIML-UHFFFAOYSA-N 77566 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-hydroxylpiperidin-1-yl)ketone::US20250387388, Compound MDI-245 BDNF/NT-3 growth factors receptor Homo sapiens 3.37 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77566&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898206 252654597 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123570 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CC(O)CCN3C(=O)N3CCC(O)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H52F2N12O5/c1-3-25-15-43(68)35(52)19-33(25)27-5-7-31-37(13-27)58-60-47(31)49-54-39-21-62(22-40(39)55-49)45-17-29(66)9-11-64(45)51(70)65-12-10-30(67)18-46(65)63-23-41-42(24-63)57-50(56-41)48-32-8-6-28(14-38(32)59-61-48)34-20-36(53)44(69)16-26(34)4-2/h5-8,13-16,19-20,29-30,45-46,66-69H,3-4,9-12,17-18,21-24H2,1-2H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) KWXFTQMTNSFIML-UHFFFAOYSA-N 77566 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-hydroxylpiperidin-1-yl)ketone::US20250387388, Compound MDI-245 NT-3 growth factor receptor Homo sapiens 0.570 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77566&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898206 252654597 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123571 CCOC(=O)N1Cc2nc(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC)ccc34)[nH]c2C1 InChI=1S/C23H22FN5O3/c1-3-12-8-20(30)16(24)9-15(12)13-5-6-14-17(7-13)27-28-21(14)22-25-18-10-29(11-19(18)26-22)23(31)32-4-2/h5-9,30H,3-4,10-11H2,1-2H3,(H,25,26)(H,27,28) PKEKBQNIURZGAO-UHFFFAOYSA-N 77568 Ethyl 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazole-5(1H)-carboxylate::US20250387388, Compound MDI-253 High affinity nerve growth factor receptor Homo sapiens 11.4 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77568&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 16745860 252654599 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123572 CCOC(=O)N1Cc2nc(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC)ccc34)[nH]c2C1 InChI=1S/C23H22FN5O3/c1-3-12-8-20(30)16(24)9-15(12)13-5-6-14-17(7-13)27-28-21(14)22-25-18-10-29(11-19(18)26-22)23(31)32-4-2/h5-9,30H,3-4,10-11H2,1-2H3,(H,25,26)(H,27,28) PKEKBQNIURZGAO-UHFFFAOYSA-N 77568 Ethyl 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazole-5(1H)-carboxylate::US20250387388, Compound MDI-253 BDNF/NT-3 growth factors receptor Homo sapiens 98.8 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77568&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 16745860 252654599 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123573 CCOC(=O)N1Cc2nc(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC)ccc34)[nH]c2C1 InChI=1S/C23H22FN5O3/c1-3-12-8-20(30)16(24)9-15(12)13-5-6-14-17(7-13)27-28-21(14)22-25-18-10-29(11-19(18)26-22)23(31)32-4-2/h5-9,30H,3-4,10-11H2,1-2H3,(H,25,26)(H,27,28) PKEKBQNIURZGAO-UHFFFAOYSA-N 77568 Ethyl 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazole-5(1H)-carboxylate::US20250387388, Compound MDI-253 NT-3 growth factor receptor Homo sapiens 13.1 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77568&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 16745860 252654599 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123574 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(C(=O)N5CCOC(N6Cc7nc(-c8n[nH]c9cc(-c%10cc(F)c(O)cc%10CC)ccc89)[nH]c7C6)C5)CCO3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O5/c1-3-25-15-41(64)33(50)17-31(25)27-5-7-29-35(13-27)56-58-45(29)47-52-37-19-62(20-38(37)53-47)43-23-60(9-11-67-43)49(66)61-10-12-68-44(24-61)63-21-39-40(22-63)55-48(54-39)46-30-8-6-28(14-36(30)57-59-46)32-18-34(51)42(65)16-26(32)4-2/h5-8,13-18,43-44,64-65H,3-4,9-12,19-24H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) AIWLPFCVLACCDJ-UHFFFAOYSA-N 77571 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(morpholino)ketone::US20250387388, Compound MDI-234 High affinity nerve growth factor receptor Homo sapiens 1.07 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77571&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2729976 252654602 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123575 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(C(=O)N5CCOC(N6Cc7nc(-c8n[nH]c9cc(-c%10cc(F)c(O)cc%10CC)ccc89)[nH]c7C6)C5)CCO3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O5/c1-3-25-15-41(64)33(50)17-31(25)27-5-7-29-35(13-27)56-58-45(29)47-52-37-19-62(20-38(37)53-47)43-23-60(9-11-67-43)49(66)61-10-12-68-44(24-61)63-21-39-40(22-63)55-48(54-39)46-30-8-6-28(14-36(30)57-59-46)32-18-34(51)42(65)16-26(32)4-2/h5-8,13-18,43-44,64-65H,3-4,9-12,19-24H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) AIWLPFCVLACCDJ-UHFFFAOYSA-N 77571 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(morpholino)ketone::US20250387388, Compound MDI-234 BDNF/NT-3 growth factors receptor Homo sapiens 1.27 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77571&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 2729976 252654602 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123576 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(C(=O)N5CCOC(N6Cc7nc(-c8n[nH]c9cc(-c%10cc(F)c(O)cc%10CC)ccc89)[nH]c7C6)C5)CCO3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O5/c1-3-25-15-41(64)33(50)17-31(25)27-5-7-29-35(13-27)56-58-45(29)47-52-37-19-62(20-38(37)53-47)43-23-60(9-11-67-43)49(66)61-10-12-68-44(24-61)63-21-39-40(22-63)55-48(54-39)46-30-8-6-28(14-36(30)57-59-46)32-18-34(51)42(65)16-26(32)4-2/h5-8,13-18,43-44,64-65H,3-4,9-12,19-24H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) AIWLPFCVLACCDJ-UHFFFAOYSA-N 77571 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(morpholino)ketone::US20250387388, Compound MDI-234 NT-3 growth factor receptor Homo sapiens 0.650 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77571&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2729976 252654602 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123577 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)NCCO)C4)n[nH]c2c1 InChI=1S/C23H23FN6O3/c1-2-12-8-20(32)16(24)9-15(12)13-3-4-14-17(7-13)28-29-21(14)22-26-18-10-30(11-19(18)27-22)23(33)25-5-6-31/h3-4,7-9,31-32H,2,5-6,10-11H2,1H3,(H,25,33)(H,26,27)(H,28,29) PSFVDMGGPAYWHU-UHFFFAOYSA-N 77572 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N-(2-hydroxylethyl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-248 High affinity nerve growth factor receptor Homo sapiens 12.0 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77572&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 5844273 252654603 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123578 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)NCCO)C4)n[nH]c2c1 InChI=1S/C23H23FN6O3/c1-2-12-8-20(32)16(24)9-15(12)13-3-4-14-17(7-13)28-29-21(14)22-26-18-10-30(11-19(18)27-22)23(33)25-5-6-31/h3-4,7-9,31-32H,2,5-6,10-11H2,1H3,(H,25,33)(H,26,27)(H,28,29) PSFVDMGGPAYWHU-UHFFFAOYSA-N 77572 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N-(2-hydroxylethyl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-248 BDNF/NT-3 growth factors receptor Homo sapiens 3.58 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77572&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 5844273 252654603 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123579 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)NCCO)C4)n[nH]c2c1 InChI=1S/C23H23FN6O3/c1-2-12-8-20(32)16(24)9-15(12)13-3-4-14-17(7-13)28-29-21(14)22-26-18-10-30(11-19(18)27-22)23(33)25-5-6-31/h3-4,7-9,31-32H,2,5-6,10-11H2,1H3,(H,25,33)(H,26,27)(H,28,29) PSFVDMGGPAYWHU-UHFFFAOYSA-N 77572 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N-(2-hydroxylethyl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-248 NT-3 growth factor receptor Homo sapiens 3.77 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77572&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 5844273 252654603 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123580 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)C3CC3)C4)n[nH]c2c1 InChI=1S/C24H22FN5O2/c1-2-12-8-21(31)17(25)9-16(12)14-5-6-15-18(7-14)28-29-22(15)23-26-19-10-30(11-20(19)27-23)24(32)13-3-4-13/h5-9,13,31H,2-4,10-11H2,1H3,(H,26,27)(H,28,29) BLJRGXUVDWQVBK-UHFFFAOYSA-N 77573 cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)pyrrolo[3,4-d]imidazol-5(1H, 4H,6H)-yl)ketone::US20250387388, Compound MDI-1233 High affinity nerve growth factor receptor Homo sapiens 12.2 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77573&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 5703897 252654604 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123581 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)C3CC3)C4)n[nH]c2c1 InChI=1S/C24H22FN5O2/c1-2-12-8-21(31)17(25)9-16(12)14-5-6-15-18(7-14)28-29-22(15)23-26-19-10-30(11-20(19)27-23)24(32)13-3-4-13/h5-9,13,31H,2-4,10-11H2,1H3,(H,26,27)(H,28,29) BLJRGXUVDWQVBK-UHFFFAOYSA-N 77573 cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)pyrrolo[3,4-d]imidazol-5(1H, 4H,6H)-yl)ketone::US20250387388, Compound MDI-1233 BDNF/NT-3 growth factors receptor Homo sapiens 4.16 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77573&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 5703897 252654604 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123582 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)C3CC3)C4)n[nH]c2c1 InChI=1S/C24H22FN5O2/c1-2-12-8-21(31)17(25)9-16(12)14-5-6-15-18(7-14)28-29-22(15)23-26-19-10-30(11-20(19)27-23)24(32)13-3-4-13/h5-9,13,31H,2-4,10-11H2,1H3,(H,26,27)(H,28,29) BLJRGXUVDWQVBK-UHFFFAOYSA-N 77573 cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)pyrrolo[3,4-d]imidazol-5(1H, 4H,6H)-yl)ketone::US20250387388, Compound MDI-1233 NT-3 growth factor receptor Homo sapiens 5.91 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77573&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 5703897 252654604 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123583 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN([C@@H]3C(O)CCN3C(=O)N3CCC(O)[C@H]3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O5/c1-3-23-15-41(66)31(50)17-29(23)25-5-7-27-33(13-25)56-58-43(27)45-52-35-19-60(20-36(35)53-45)47-39(64)9-11-62(47)49(68)63-12-10-40(65)48(63)61-21-37-38(22-61)55-46(54-37)44-28-8-6-26(14-34(28)57-59-44)30-18-32(51)42(67)16-24(30)4-2/h5-8,13-18,39-40,47-48,64-67H,3-4,9-12,19-22H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) RZQHIFIUWXAUDG-UHFFFAOYSA-N 77574 (S)-(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(3-hydroxylpyrrolidin-1-yl)ketone::US20250387388, Compound MDI-1228 High affinity nerve growth factor receptor Homo sapiens 1.82 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77574&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898207 252654605 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123584 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN([C@@H]3C(O)CCN3C(=O)N3CCC(O)[C@H]3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O5/c1-3-23-15-41(66)31(50)17-29(23)25-5-7-27-33(13-25)56-58-43(27)45-52-35-19-60(20-36(35)53-45)47-39(64)9-11-62(47)49(68)63-12-10-40(65)48(63)61-21-37-38(22-61)55-46(54-37)44-28-8-6-26(14-34(28)57-59-44)30-18-32(51)42(67)16-24(30)4-2/h5-8,13-18,39-40,47-48,64-67H,3-4,9-12,19-22H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) RZQHIFIUWXAUDG-UHFFFAOYSA-N 77574 (S)-(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(3-hydroxylpyrrolidin-1-yl)ketone::US20250387388, Compound MDI-1228 BDNF/NT-3 growth factors receptor Homo sapiens 1.77 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77574&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898207 252654605 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123585 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN([C@@H]3C(O)CCN3C(=O)N3CCC(O)[C@H]3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O5/c1-3-23-15-41(66)31(50)17-29(23)25-5-7-27-33(13-25)56-58-43(27)45-52-35-19-60(20-36(35)53-45)47-39(64)9-11-62(47)49(68)63-12-10-40(65)48(63)61-21-37-38(22-61)55-46(54-37)44-28-8-6-26(14-34(28)57-59-44)30-18-32(51)42(67)16-24(30)4-2/h5-8,13-18,39-40,47-48,64-67H,3-4,9-12,19-22H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) RZQHIFIUWXAUDG-UHFFFAOYSA-N 77574 (S)-(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(3-hydroxylpyrrolidin-1-yl)ketone::US20250387388, Compound MDI-1228 NT-3 growth factor receptor Homo sapiens 0.600 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77574&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 91898207 252654605 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123586 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CCCN3C(=O)N3CCCC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O3/c1-3-25-17-41(64)33(50)19-31(25)27-9-11-29-35(15-27)56-58-45(29)47-52-37-21-60(22-38(37)53-47)43-7-5-13-62(43)49(66)63-14-6-8-44(63)61-23-39-40(24-61)55-48(54-39)46-30-12-10-28(16-36(30)57-59-46)32-20-34(51)42(65)18-26(32)4-2/h9-12,15-20,43-44,64-65H,3-8,13-14,21-24H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) LIMOPICTXIKSLM-UHFFFAOYSA-N 77575 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(pyrrolidin-1-yl)ketone::US20250387388, Compound MDI-231 High affinity nerve growth factor receptor Homo sapiens 2.82 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77575&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 5703896 252654606 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123587 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CCCN3C(=O)N3CCCC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O3/c1-3-25-17-41(64)33(50)19-31(25)27-9-11-29-35(15-27)56-58-45(29)47-52-37-21-60(22-38(37)53-47)43-7-5-13-62(43)49(66)63-14-6-8-44(63)61-23-39-40(24-61)55-48(54-39)46-30-12-10-28(16-36(30)57-59-46)32-20-34(51)42(65)18-26(32)4-2/h9-12,15-20,43-44,64-65H,3-8,13-14,21-24H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) LIMOPICTXIKSLM-UHFFFAOYSA-N 77575 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(pyrrolidin-1-yl)ketone::US20250387388, Compound MDI-231 BDNF/NT-3 growth factors receptor Homo sapiens 5.86 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77575&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 5703896 252654606 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123588 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CCCN3C(=O)N3CCCC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O3/c1-3-25-17-41(64)33(50)19-31(25)27-9-11-29-35(15-27)56-58-45(29)47-52-37-21-60(22-38(37)53-47)43-7-5-13-62(43)49(66)63-14-6-8-44(63)61-23-39-40(24-61)55-48(54-39)46-30-12-10-28(16-36(30)57-59-46)32-20-34(51)42(65)18-26(32)4-2/h9-12,15-20,43-44,64-65H,3-8,13-14,21-24H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) LIMOPICTXIKSLM-UHFFFAOYSA-N 77575 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(pyrrolidin-1-yl)ketone::US20250387388, Compound MDI-231 NT-3 growth factor receptor Homo sapiens 1.49 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77575&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 5703896 252654606 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123589 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CCCCN3C(=O)N3CCCCC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H52F2N12O3/c1-3-27-19-43(66)35(52)21-33(27)29-11-13-31-37(17-29)58-60-47(31)49-54-39-23-62(24-40(39)55-49)45-9-5-7-15-64(45)51(68)65-16-8-6-10-46(65)63-25-41-42(26-63)57-50(56-41)48-32-14-12-30(18-38(32)59-61-48)34-22-36(53)44(67)20-28(34)4-2/h11-14,17-22,45-46,66-67H,3-10,15-16,23-26H2,1-2H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) CNBLRXWIUSVNQC-UHFFFAOYSA-N 77577 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(piperidin-1-yl)ketone::US20250387388, Compound MDI-233 High affinity nerve growth factor receptor Homo sapiens 9.01 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77577&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2872439 252654608 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123590 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CCCCN3C(=O)N3CCCCC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H52F2N12O3/c1-3-27-19-43(66)35(52)21-33(27)29-11-13-31-37(17-29)58-60-47(31)49-54-39-23-62(24-40(39)55-49)45-9-5-7-15-64(45)51(68)65-16-8-6-10-46(65)63-25-41-42(26-63)57-50(56-41)48-32-14-12-30(18-38(32)59-61-48)34-22-36(53)44(67)20-28(34)4-2/h11-14,17-22,45-46,66-67H,3-10,15-16,23-26H2,1-2H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) CNBLRXWIUSVNQC-UHFFFAOYSA-N 77577 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(piperidin-1-yl)ketone::US20250387388, Compound MDI-233 BDNF/NT-3 growth factors receptor Homo sapiens 30.4 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77577&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 2872439 252654608 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123591 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CCCCN3C(=O)N3CCCCC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H52F2N12O3/c1-3-27-19-43(66)35(52)21-33(27)29-11-13-31-37(17-29)58-60-47(31)49-54-39-23-62(24-40(39)55-49)45-9-5-7-15-64(45)51(68)65-16-8-6-10-46(65)63-25-41-42(26-63)57-50(56-41)48-32-14-12-30(18-38(32)59-61-48)34-22-36(53)44(67)20-28(34)4-2/h11-14,17-22,45-46,66-67H,3-10,15-16,23-26H2,1-2H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) CNBLRXWIUSVNQC-UHFFFAOYSA-N 77577 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(piperidin-1-yl)ketone::US20250387388, Compound MDI-233 NT-3 growth factor receptor Homo sapiens 6.32 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77577&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2872439 252654608 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123592 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(CC)CCN3C(=O)N3CCN(CC)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C53H58F2N14O3/c1-5-29-19-45(70)37(54)21-35(29)31-9-11-33-39(17-31)60-62-49(33)51-56-41-23-66(24-42(41)57-51)47-27-64(7-3)13-15-68(47)53(72)69-16-14-65(8-4)28-48(69)67-25-43-44(26-67)59-52(58-43)50-34-12-10-32(18-40(34)61-63-50)36-22-38(55)46(71)20-30(36)6-2/h9-12,17-22,47-48,70-71H,5-8,13-16,23-28H2,1-4H3,(H,56,57)(H,58,59)(H,60,62)(H,61,63) WAULMQHQMKQAJI-UHFFFAOYSA-N 77578 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-ethylpiperazin-1-yl)ketone::US20250387388, Compound MDI-236 High affinity nerve growth factor receptor Homo sapiens 0.230 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77578&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2921215 252654609 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123593 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(CC)CCN3C(=O)N3CCN(CC)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C53H58F2N14O3/c1-5-29-19-45(70)37(54)21-35(29)31-9-11-33-39(17-31)60-62-49(33)51-56-41-23-66(24-42(41)57-51)47-27-64(7-3)13-15-68(47)53(72)69-16-14-65(8-4)28-48(69)67-25-43-44(26-67)59-52(58-43)50-34-12-10-32(18-40(34)61-63-50)36-22-38(55)46(71)20-30(36)6-2/h9-12,17-22,47-48,70-71H,5-8,13-16,23-28H2,1-4H3,(H,56,57)(H,58,59)(H,60,62)(H,61,63) WAULMQHQMKQAJI-UHFFFAOYSA-N 77578 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-ethylpiperazin-1-yl)ketone::US20250387388, Compound MDI-236 BDNF/NT-3 growth factors receptor Homo sapiens 1.06 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77578&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 2921215 252654609 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123594 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(CC)CCN3C(=O)N3CCN(CC)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C53H58F2N14O3/c1-5-29-19-45(70)37(54)21-35(29)31-9-11-33-39(17-31)60-62-49(33)51-56-41-23-66(24-42(41)57-51)47-27-64(7-3)13-15-68(47)53(72)69-16-14-65(8-4)28-48(69)67-25-43-44(26-67)59-52(58-43)50-34-12-10-32(18-40(34)61-63-50)36-22-38(55)46(71)20-30(36)6-2/h9-12,17-22,47-48,70-71H,5-8,13-16,23-28H2,1-4H3,(H,56,57)(H,58,59)(H,60,62)(H,61,63) WAULMQHQMKQAJI-UHFFFAOYSA-N 77578 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-ethylpiperazin-1-yl)ketone::US20250387388, Compound MDI-236 NT-3 growth factor receptor Homo sapiens 0.200 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77578&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2921215 252654609 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123595 CCNC(=O)N1Cc2nc(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC)ccc34)[nH]c2C1 InChI=1S/C23H23FN6O2/c1-3-12-8-20(31)16(24)9-15(12)13-5-6-14-17(7-13)28-29-21(14)22-26-18-10-30(11-19(18)27-22)23(32)25-4-2/h5-9,31H,3-4,10-11H2,1-2H3,(H,25,32)(H,26,27)(H,28,29) HBGCWGAFPWCNBZ-UHFFFAOYSA-N 77579 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N-ethyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-247 High affinity nerve growth factor receptor Homo sapiens 10.3 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77579&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2921404 252654610 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123596 CCNC(=O)N1Cc2nc(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC)ccc34)[nH]c2C1 InChI=1S/C23H23FN6O2/c1-3-12-8-20(31)16(24)9-15(12)13-5-6-14-17(7-13)28-29-21(14)22-26-18-10-30(11-19(18)27-22)23(32)25-4-2/h5-9,31H,3-4,10-11H2,1-2H3,(H,25,32)(H,26,27)(H,28,29) HBGCWGAFPWCNBZ-UHFFFAOYSA-N 77579 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N-ethyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-247 BDNF/NT-3 growth factors receptor Homo sapiens 34.2 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77579&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 2921404 252654610 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123597 CCNC(=O)N1Cc2nc(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC)ccc34)[nH]c2C1 InChI=1S/C23H23FN6O2/c1-3-12-8-20(31)16(24)9-15(12)13-5-6-14-17(7-13)28-29-21(14)22-26-18-10-30(11-19(18)27-22)23(32)25-4-2/h5-9,31H,3-4,10-11H2,1-2H3,(H,25,32)(H,26,27)(H,28,29) HBGCWGAFPWCNBZ-UHFFFAOYSA-N 77579 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N-ethyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-247 NT-3 growth factor receptor Homo sapiens 3.73 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77579&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2921404 252654610 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123598 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N(C)C)C4)n[nH]c2c1 InChI=1S/C23H23FN6O2/c1-4-12-8-20(31)16(24)9-15(12)13-5-6-14-17(7-13)27-28-21(14)22-25-18-10-30(11-19(18)26-22)23(32)29(2)3/h5-9,31H,4,10-11H2,1-3H3,(H,25,26)(H,27,28) GSKNEMZIKIGZJJ-UHFFFAOYSA-N 77580 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N,N-dimethyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-257 High affinity nerve growth factor receptor Homo sapiens 2.21 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77580&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2920814 252654611 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123599 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N(C)C)C4)n[nH]c2c1 InChI=1S/C23H23FN6O2/c1-4-12-8-20(31)16(24)9-15(12)13-5-6-14-17(7-13)27-28-21(14)22-25-18-10-30(11-19(18)26-22)23(32)29(2)3/h5-9,31H,4,10-11H2,1-3H3,(H,25,26)(H,27,28) GSKNEMZIKIGZJJ-UHFFFAOYSA-N 77580 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N,N-dimethyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-257 BDNF/NT-3 growth factors receptor Homo sapiens 2.93 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77580&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 2920814 252654611 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123600 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N(C)C)C4)n[nH]c2c1 InChI=1S/C23H23FN6O2/c1-4-12-8-20(31)16(24)9-15(12)13-5-6-14-17(7-13)27-28-21(14)22-25-18-10-30(11-19(18)26-22)23(32)29(2)3/h5-9,31H,4,10-11H2,1-3H3,(H,25,26)(H,27,28) GSKNEMZIKIGZJJ-UHFFFAOYSA-N 77580 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N,N-dimethyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-257 NT-3 growth factor receptor Homo sapiens 0.720 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77580&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2920814 252654611 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123601 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N3CC(O)C3)C4)n[nH]c2c1 InChI=1S/C24H23FN6O3/c1-2-12-6-21(33)17(25)7-16(12)13-3-4-15-18(5-13)28-29-22(15)23-26-19-10-31(11-20(19)27-23)24(34)30-8-14(32)9-30/h3-7,14,32-33H,2,8-11H2,1H3,(H,26,27)(H,28,29) JLQSWGFHOKZCMG-UHFFFAOYSA-N 77581 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl) (3-hydroxyazetidin-1-yl)ketone::US20250387388, Compound MDI-1288 High affinity nerve growth factor receptor Homo sapiens 0.890 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=3688&target=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77581&enzyme=High+affinity+nerve+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2876744 252654612 1 MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG 2IFG,5H3Q,4AOJ,5KMO,5KMN,5KMM,5KML,5KMK,5KMJ,5KMI,9DAI,6DKI,6DKG,6DKB,6D20,6D1Z,6D1Y,7XBI,6PME,6PMC,6PMB,6PMA,6PL4,6PL3,6PL2,6PL1,6NSS,6NPT,5WR7,8J63,8J61,7XAF,4F0I,6NSP,6IQN,7VKO,6J5L,4YPS,4YNE,6DKW,6D22,5JFX,5JFW,5JFV,5JFS,5I8A,5KVT,4PMT,4PMS,4PMP,4PMM,1HE7,1WWA,8YTE,8YTD,1WWW High affinity nerve growth factor receptor NTRK1_HUMAN P04629 B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7 123602 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N3CC(O)C3)C4)n[nH]c2c1 InChI=1S/C24H23FN6O3/c1-2-12-6-21(33)17(25)7-16(12)13-3-4-15-18(5-13)28-29-22(15)23-26-19-10-31(11-20(19)27-23)24(34)30-8-14(32)9-30/h3-7,14,32-33H,2,8-11H2,1H3,(H,26,27)(H,28,29) JLQSWGFHOKZCMG-UHFFFAOYSA-N 77581 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl) (3-hydroxyazetidin-1-yl)ketone::US20250387388, Compound MDI-1288 BDNF/NT-3 growth factors receptor Homo sapiens 1.04 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6476&target=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77581&enzyme=BDNF%2FNT-3+growth+factors+receptor&column=ki&startPg=0&Increment=50&submit=Search 2876744 252654612 1 MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG 4AT5,4AT4,4AT3,4ASZ,5MO9,1WWB BDNF/NT-3 growth factors receptor NTRK2_HUMAN Q16620 B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7 123603 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N3CC(O)C3)C4)n[nH]c2c1 InChI=1S/C24H23FN6O3/c1-2-12-6-21(33)17(25)7-16(12)13-3-4-15-18(5-13)28-29-22(15)23-26-19-10-31(11-20(19)27-23)24(34)30-8-14(32)9-30/h3-7,14,32-33H,2,8-11H2,1H3,(H,26,27)(H,28,29) JLQSWGFHOKZCMG-UHFFFAOYSA-N 77581 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl) (3-hydroxyazetidin-1-yl)ketone::US20250387388, Compound MDI-1288 NT-3 growth factor receptor Homo sapiens 0.590 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6477&target=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77581&enzyme=NT-3+growth+factor+receptor&column=ki&startPg=0&Increment=50&submit=Search 2876744 252654612 1 MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG 6KZD,6KZC,3V5Q NT-3 growth factor receptor NTRK3_HUMAN Q16288 B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289 123604 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CN(C)CCN3C(=O)N3CCN(C)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H54F2N14O3/c1-5-27-17-43(68)35(52)19-33(27)29-7-9-31-37(15-29)58-60-47(31)49-54-39-21-64(22-40(39)55-49)45-25-62(3)11-13-66(45)51(70)67-14-12-63(4)26-46(67)65-23-41-42(24-65)57-50(56-41)48-32-10-8-30(16-38(32)59-61-48)34-20-36(53)44(69)18-28(34)6-2/h7-10,15-20,45-46,68-69H,5-6,11-14,21-26H2,1-4H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) DQQXGBLWMGYGAL-UHFFFAOYSA-N 77565 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-methylpiperazin-1-yl)ketone::US20250387388, Compound MDI-235 Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens 0.100 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5974&target=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77565&enzyme=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search 91898205 252654596 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 6GL7,6Q2S,6Q2R,6Q2O,6Q2N,6Q2J,5FM3,5FM2,7RUN,6VHG Proto-oncogene tyrosine-protein kinase receptor Ret RET_HUMAN P07949 A8K6Z2 Q15250 Q9BTB0 Q9H4A2 123605 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CC(O)CCN3C(=O)N3CCC(O)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C51H52F2N12O5/c1-3-25-15-43(68)35(52)19-33(25)27-5-7-31-37(13-27)58-60-47(31)49-54-39-21-62(22-40(39)55-49)45-17-29(66)9-11-64(45)51(70)65-12-10-30(67)18-46(65)63-23-41-42(24-63)57-50(56-41)48-32-8-6-28(14-38(32)59-61-48)34-20-36(53)44(69)16-26(34)4-2/h5-8,13-16,19-20,29-30,45-46,66-69H,3-4,9-12,17-18,21-24H2,1-2H3,(H,54,55)(H,56,57)(H,58,60)(H,59,61) KWXFTQMTNSFIML-UHFFFAOYSA-N 77566 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(4-hydroxylpiperidin-1-yl)ketone::US20250387388, Compound MDI-245 Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens 0.990 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5974&target=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77566&enzyme=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search 91898206 252654597 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 6GL7,6Q2S,6Q2R,6Q2O,6Q2N,6Q2J,5FM3,5FM2,7RUN,6VHG Proto-oncogene tyrosine-protein kinase receptor Ret RET_HUMAN P07949 A8K6Z2 Q15250 Q9BTB0 Q9H4A2 123606 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)C3CC3)C4)n[nH]c2c1 InChI=1S/C24H22FN5O2/c1-2-12-8-21(31)17(25)9-16(12)14-5-6-15-18(7-14)28-29-22(15)23-26-19-10-30(11-20(19)27-23)24(32)13-3-4-13/h5-9,13,31H,2-4,10-11H2,1H3,(H,26,27)(H,28,29) BLJRGXUVDWQVBK-UHFFFAOYSA-N 77573 cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)pyrrolo[3,4-d]imidazol-5(1H, 4H,6H)-yl)ketone::US20250387388, Compound MDI-1233 Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens 4.21 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5974&target=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77573&enzyme=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search 5703897 252654604 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 6GL7,6Q2S,6Q2R,6Q2O,6Q2N,6Q2J,5FM3,5FM2,7RUN,6VHG Proto-oncogene tyrosine-protein kinase receptor Ret RET_HUMAN P07949 A8K6Z2 Q15250 Q9BTB0 Q9H4A2 123607 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN([C@@H]3C(O)CCN3C(=O)N3CCC(O)[C@H]3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1 InChI=1S/C49H48F2N12O5/c1-3-23-15-41(66)31(50)17-29(23)25-5-7-27-33(13-25)56-58-43(27)45-52-35-19-60(20-36(35)53-45)47-39(64)9-11-62(47)49(68)63-12-10-40(65)48(63)61-21-37-38(22-61)55-46(54-37)44-28-8-6-26(14-34(28)57-59-44)30-18-32(51)42(67)16-24(30)4-2/h5-8,13-18,39-40,47-48,64-67H,3-4,9-12,19-22H2,1-2H3,(H,52,53)(H,54,55)(H,56,58)(H,57,59) RZQHIFIUWXAUDG-UHFFFAOYSA-N 77574 (S)-(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl)(3-hydroxylpyrrolidin-1-yl)ketone::US20250387388, Compound MDI-1228 Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens 0.620 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5974&target=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77574&enzyme=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search 91898207 252654605 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 6GL7,6Q2S,6Q2R,6Q2O,6Q2N,6Q2J,5FM3,5FM2,7RUN,6VHG Proto-oncogene tyrosine-protein kinase receptor Ret RET_HUMAN P07949 A8K6Z2 Q15250 Q9BTB0 Q9H4A2 123608 CCNC(=O)N1Cc2nc(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC)ccc34)[nH]c2C1 InChI=1S/C23H23FN6O2/c1-3-12-8-20(31)16(24)9-15(12)13-5-6-14-17(7-13)28-29-21(14)22-26-18-10-30(11-19(18)27-22)23(32)25-4-2/h5-9,31H,3-4,10-11H2,1-2H3,(H,25,32)(H,26,27)(H,28,29) HBGCWGAFPWCNBZ-UHFFFAOYSA-N 77579 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-N-ethyl-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-carboxamide::US20250387388, Compound MDI-247 Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens 8.36 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5974&target=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77579&enzyme=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search 2921404 252654610 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 6GL7,6Q2S,6Q2R,6Q2O,6Q2N,6Q2J,5FM3,5FM2,7RUN,6VHG Proto-oncogene tyrosine-protein kinase receptor Ret RET_HUMAN P07949 A8K6Z2 Q15250 Q9BTB0 Q9H4A2 123609 CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N3CC(O)C3)C4)n[nH]c2c1 InChI=1S/C24H23FN6O3/c1-2-12-6-21(33)17(25)7-16(12)13-3-4-15-18(5-13)28-29-22(15)23-26-19-10-31(11-20(19)27-23)24(34)30-8-14(32)9-30/h3-7,14,32-33H,2,8-11H2,1H3,(H,26,27)(H,28,29) JLQSWGFHOKZCMG-UHFFFAOYSA-N 77581 (2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl)-4,6-dihydropyrrolo[3,4-d]imidazol-5(1H)-yl) (3-hydroxyazetidin-1-yl)ketone::US20250387388, Compound MDI-1288 Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens 3.43 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=77581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5974&target=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=77581&enzyme=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search 2876744 252654612 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 6GL7,6Q2S,6Q2R,6Q2O,6Q2N,6Q2J,5FM3,5FM2,7RUN,6VHG Proto-oncogene tyrosine-protein kinase receptor Ret RET_HUMAN P07949 A8K6Z2 Q15250 Q9BTB0 Q9H4A2 123610 COC1(CCC(CC1)c1nc(C)cc(Nc2cc(C)[nH]n2)n1)C(=O)N[C@@H](C)c1ccc(nc1)-n1cc(F)cn1 |r| InChI=1S/C27H32FN9O2/c1-16-11-22(33-23-12-17(2)35-36-23)34-25(31-16)19-7-9-27(39-4,10-8-19)26(38)32-18(3)20-5-6-24(29-13-20)37-15-21(28)14-30-37/h5-6,11-15,18-19H,7-10H2,1-4H3,(H,32,38)(H2,31,33,34,35,36) GBLBJPZSROAGMF-UHFFFAOYSA-N 50601766 CHEMBL5171764::US20250387388, Compound Pralsetinib(Positive control) Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens 0.140 US Patent 10.7270/Q2833XT6 US20250387388 LU, L; HUANG, H; ZHANG, L; ZHAO, S; ZHANG, J 12/25/2025 5/6/2026 Medinno Pharmaceutical Technology (Zhuhai) Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50601766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5974&target=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50601766&enzyme=Proto-oncogene+tyrosine-protein+kinase+receptor+Ret&column=ki&startPg=0&Increment=50&submit=Search 129073603 482612617 1 MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCSTLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLCDELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDTFDS 6GL7,6Q2S,6Q2R,6Q2O,6Q2N,6Q2J,5FM3,5FM2,7RUN,6VHG Proto-oncogene tyrosine-protein kinase receptor Ret RET_HUMAN P07949 A8K6Z2 Q15250 Q9BTB0 Q9H4A2