BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
123673	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC(C)(C)O)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H22F3N5O4/c1-9-4-5-10(18(31,16(24)29)19(20,21)22)6-11(9)12-7-25-14(23)13(27-12)15(28)26-8-17(2,3)30/h4-7,30-31H,8H2,1-3H3,(H2,23,25)(H2,24,29)(H,26,28)	DVRSFYPTVOWAFS-UHFFFAOYSA-N	506846	US11046658, Example 1::US20250388553, Example 1	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506846&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150103226	459091985							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123674	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC(C)(C)O)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H22F3N5O4/c1-9-4-5-10(18(31,16(24)29)19(20,21)22)6-11(9)12-7-25-14(23)13(27-12)15(28)26-8-17(2,3)30/h4-7,30-31H,8H2,1-3H3,(H2,23,25)(H2,24,29)(H,26,28)	DVRSFYPTVOWAFS-UHFFFAOYSA-N	506846	US11046658, Example 1::US20250388553, Example 1	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506846&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150103226	459091985							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123675	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCOCC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H22F3N5O4/c1-10-2-3-11(19(31,18(25)30)20(21,22)23)8-13(10)14-9-26-16(24)15(28-14)17(29)27-12-4-6-32-7-5-12/h2-3,8-9,12,31H,4-7H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	RTPBQTKGQYJBLB-UHFFFAOYSA-N	506847	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N- (tetrahydro-2H-pyran-4- yl)pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 2::US20250388553, Example 2	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506847&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151776008	459091986							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123676	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCOCC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H22F3N5O4/c1-10-2-3-11(19(31,18(25)30)20(21,22)23)8-13(10)14-9-26-16(24)15(28-14)17(29)27-12-4-6-32-7-5-12/h2-3,8-9,12,31H,4-7H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	RTPBQTKGQYJBLB-UHFFFAOYSA-N	506847	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N- (tetrahydro-2H-pyran-4- yl)pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 2::US20250388553, Example 2	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506847&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151776008	459091986							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123677	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CCC(O)CC2)n1	InChI=1S/C21H24F3N5O4/c1-10-2-3-11(20(33,19(26)32)21(22,23)24)8-14(10)15-9-27-17(25)16(29-15)18(31)28-12-4-6-13(30)7-5-12/h2-3,8-9,12-13,30,33H,4-7H2,1H3,(H2,25,27)(H2,26,32)(H,28,31)	DYRDFUVSEUEBSH-UHFFFAOYSA-N	79493	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4- hydroxycyclohexyl)pyrazine- 2-carboxamide trifluoroacetate::US20250388553, Example 3	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79493&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			4817555	252656144							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123678	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CCC(O)CC2)n1	InChI=1S/C21H24F3N5O4/c1-10-2-3-11(20(33,19(26)32)21(22,23)24)8-14(10)15-9-27-17(25)16(29-15)18(31)28-12-4-6-13(30)7-5-12/h2-3,8-9,12-13,30,33H,4-7H2,1H3,(H2,25,27)(H2,26,32)(H,28,31)	DYRDFUVSEUEBSH-UHFFFAOYSA-N	79493	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4- hydroxycyclohexyl)pyrazine- 2-carboxamide trifluoroacetate::US20250388553, Example 3	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79493	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79493&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			4817555	252656144							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123679	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC1(CC1)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H19F3N6O3/c1-10-2-3-11(19(32,17(26)31)20(21,22)23)6-12(10)13-7-27-15(25)14(29-13)16(30)28-9-18(8-24)4-5-18/h2-3,6-7,32H,4-5,9H2,1H3,(H2,25,27)(H2,26,31)(H,28,30)	NFEKXMDXUCRDLQ-UHFFFAOYSA-N	506849	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1- cyanocyclopropyl)methyl) pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 4::US20250388553, Example 4	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506849&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151185360	459091988							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123680	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC1(CC1)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H19F3N6O3/c1-10-2-3-11(19(32,17(26)31)20(21,22)23)6-12(10)13-7-27-15(25)14(29-13)16(30)28-9-18(8-24)4-5-18/h2-3,6-7,32H,4-5,9H2,1H3,(H2,25,27)(H2,26,31)(H,28,30)	NFEKXMDXUCRDLQ-UHFFFAOYSA-N	506849	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1- cyanocyclopropyl)methyl) pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 4::US20250388553, Example 4	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506849&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151185360	459091988							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123681	CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H20F3N5O3/c1-8(2)25-15(27)13-14(22)24-7-12(26-13)11-6-10(5-4-9(11)3)17(29,16(23)28)18(19,20)21/h4-8,29H,1-3H3,(H2,22,24)(H2,23,28)(H,25,27)	VVLVYJCIPGFBIU-UHFFFAOYSA-N	506850	US11046658, Example 5::US20250388553, Example 5	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506850&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152201987	459091989							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123682	CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H20F3N5O3/c1-8(2)25-15(27)13-14(22)24-7-12(26-13)11-6-10(5-4-9(11)3)17(29,16(23)28)18(19,20)21/h4-8,29H,1-3H3,(H2,22,24)(H2,23,28)(H,25,27)	VVLVYJCIPGFBIU-UHFFFAOYSA-N	506850	US11046658, Example 5::US20250388553, Example 5	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506850&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152201987	459091989							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123683	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCC(F)(F)CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H22F5N5O3/c1-10-2-3-11(20(34,18(28)33)21(24,25)26)8-13(10)14-9-29-16(27)15(31-14)17(32)30-12-4-6-19(22,23)7-5-12/h2-3,8-9,12,34H,4-7H2,1H3,(H2,27,29)(H2,28,33)(H,30,32)	ZSHMEUPLOJLJKP-UHFFFAOYSA-N	506851	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(4,4- difluorocyclohexyl) pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 6::US20250388553, Example 6	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506851&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152704595	459091990							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123684	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCC(F)(F)CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H22F5N5O3/c1-10-2-3-11(20(34,18(28)33)21(24,25)26)8-13(10)14-9-29-16(27)15(31-14)17(32)30-12-4-6-19(22,23)7-5-12/h2-3,8-9,12,34H,4-7H2,1H3,(H2,27,29)(H2,28,33)(H,30,32)	ZSHMEUPLOJLJKP-UHFFFAOYSA-N	506851	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(4,4- difluorocyclohexyl) pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 6::US20250388553, Example 6	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506851&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152704595	459091990							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123685	CCNC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H18F3N5O3/c1-3-23-14(26)12-13(21)24-7-11(25-12)10-6-9(5-4-8(10)2)16(28,15(22)27)17(18,19)20/h4-7,28H,3H2,1-2H3,(H2,21,24)(H2,22,27)(H,23,26)	YLOQCCWGCSSSCB-UHFFFAOYSA-N	506852	US11046658, Example 7::US20250388553, Example 7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506852&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149380624	459091991							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123686	CCNC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H18F3N5O3/c1-3-23-14(26)12-13(21)24-7-11(25-12)10-6-9(5-4-8(10)2)16(28,15(22)27)17(18,19)20/h4-7,28H,3H2,1-2H3,(H2,21,24)(H2,22,27)(H,23,26)	YLOQCCWGCSSSCB-UHFFFAOYSA-N	506852	US11046658, Example 7::US20250388553, Example 7	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506852&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149380624	459091991							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123687	C[C@@H](CC#N)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C19H19F3N6O3/c1-9-3-4-11(18(31,17(25)30)19(20,21)22)7-12(9)13-8-26-15(24)14(28-13)16(29)27-10(2)5-6-23/h3-4,7-8,10,31H,5H2,1-2H3,(H2,24,26)(H2,25,30)(H,27,29)	VGFDXPUTCGTXEL-UHFFFAOYSA-N	506853	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)-1- cyanopropan-2-yl)pyrazine- 2-carboxamide trifluoroacetate::US11046658, Example 8::US20250388553, Example 8	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506853&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152125993	459091992							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123688	C[C@@H](CC#N)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C19H19F3N6O3/c1-9-3-4-11(18(31,17(25)30)19(20,21)22)7-12(9)13-8-26-15(24)14(28-13)16(29)27-10(2)5-6-23/h3-4,7-8,10,31H,5H2,1-2H3,(H2,24,26)(H2,25,30)(H,27,29)	VGFDXPUTCGTXEL-UHFFFAOYSA-N	506853	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)-1- cyanopropan-2-yl)pyrazine- 2-carboxamide trifluoroacetate::US11046658, Example 8::US20250388553, Example 8	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506853&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152125993	459091992							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123689	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@@H]1CCCOC1)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C20H22F3N5O4/c1-10-4-5-11(19(31,18(25)30)20(21,22)23)7-13(10)14-8-26-16(24)15(28-14)17(29)27-12-3-2-6-32-9-12/h4-5,7-8,12,31H,2-3,6,9H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	PZDSRBUHORVDBX-UHFFFAOYSA-N	506854	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((R)- tetrahydro-2H-pyran-3- yl)pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 9::US20250388553, Example 9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506854&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151544457	459091993							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123690	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@@H]1CCCOC1)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C20H22F3N5O4/c1-10-4-5-11(19(31,18(25)30)20(21,22)23)7-13(10)14-8-26-16(24)15(28-14)17(29)27-12-3-2-6-32-9-12/h4-5,7-8,12,31H,2-3,6,9H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	PZDSRBUHORVDBX-UHFFFAOYSA-N	506854	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((R)- tetrahydro-2H-pyran-3- yl)pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 9::US20250388553, Example 9	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506854&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151544457	459091993							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123691	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@H]1CCCOC1)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C20H22F3N5O4/c1-10-4-5-11(19(31,18(25)30)20(21,22)23)7-13(10)14-8-26-16(24)15(28-14)17(29)27-12-3-2-6-32-9-12/h4-5,7-8,12,31H,2-3,6,9H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	PZDSRBUHORVDBX-UHFFFAOYSA-N	506855	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)- tetrahydro-2H-pyran-3- yl)pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 10::US20250388553, Example 10	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506855&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151544456	459091994							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123692	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@H]1CCCOC1)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C20H22F3N5O4/c1-10-4-5-11(19(31,18(25)30)20(21,22)23)7-13(10)14-8-26-16(24)15(28-14)17(29)27-12-3-2-6-32-9-12/h4-5,7-8,12,31H,2-3,6,9H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	PZDSRBUHORVDBX-UHFFFAOYSA-N	506855	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)- tetrahydro-2H-pyran-3- yl)pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 10::US20250388553, Example 10	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506855&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151544456	459091994							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123693	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@H]1CCOC1)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C19H20F3N5O4/c1-9-2-3-10(18(30,17(24)29)19(20,21)22)6-12(9)13-7-25-15(23)14(27-13)16(28)26-11-4-5-31-8-11/h2-3,6-7,11,30H,4-5,8H2,1H3,(H2,23,25)(H2,24,29)(H,26,28)	VCOIUVJITHFGNP-UHFFFAOYSA-N	506856	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)- tetrahydrofuran-3- yl)pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 11::US20250388553, Example 11	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506856&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152107714	459091995							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123694	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@H]1CCOC1)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C19H20F3N5O4/c1-9-2-3-10(18(30,17(24)29)19(20,21)22)6-12(9)13-7-25-15(23)14(27-13)16(28)26-11-4-5-31-8-11/h2-3,6-7,11,30H,4-5,8H2,1H3,(H2,23,25)(H2,24,29)(H,26,28)	VCOIUVJITHFGNP-UHFFFAOYSA-N	506856	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)- tetrahydrofuran-3- yl)pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 11::US20250388553, Example 11	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506856&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152107714	459091995							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123695	C[C@@H](CO)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C18H20F3N5O4/c1-8-3-4-10(17(30,16(23)29)18(19,20)21)5-11(8)12-6-24-14(22)13(26-12)15(28)25-9(2)7-27/h3-6,9,27,30H,7H2,1-2H3,(H2,22,24)(H2,23,29)(H,25,28)	NRQCZBMMSUNIJX-UHFFFAOYSA-N	506857	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)-1- hydroxypropan-2- yl)pyrazine-2-carboxamide::US11046658, Example 12::US20250388553, Example 12	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506857&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151247586	459091996							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123696	C[C@@H](CO)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C18H20F3N5O4/c1-8-3-4-10(17(30,16(23)29)18(19,20)21)5-11(8)12-6-24-14(22)13(26-12)15(28)25-9(2)7-27/h3-6,9,27,30H,7H2,1-2H3,(H2,22,24)(H2,23,29)(H,25,28)	NRQCZBMMSUNIJX-UHFFFAOYSA-N	506857	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)-1- hydroxypropan-2- yl)pyrazine-2-carboxamide::US11046658, Example 12::US20250388553, Example 12	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506857&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151247586	459091996							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123697	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC(C)(C)CO)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H22F3N5O4/c1-9-4-5-10(18(31,16(24)30)19(20,21)22)6-11(9)12-7-25-14(23)13(26-12)15(29)27-17(2,3)8-28/h4-7,28,31H,8H2,1-3H3,(H2,23,25)(H2,24,30)(H,27,29)	GMZKQLWONGKMEI-UHFFFAOYSA-N	506858	US11046658, Example 13::US20250388553, Example 13	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506858&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150317870	459091997							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123698	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC(C)(C)CO)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H22F3N5O4/c1-9-4-5-10(18(31,16(24)30)19(20,21)22)6-11(9)12-7-25-14(23)13(26-12)15(29)27-17(2,3)8-28/h4-7,28,31H,8H2,1-3H3,(H2,23,25)(H2,24,30)(H,27,29)	GMZKQLWONGKMEI-UHFFFAOYSA-N	506858	US11046658, Example 13::US20250388553, Example 13	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506858&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150317870	459091997							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123699	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCCC#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H17F3N6O3/c1-9-3-4-10(17(30,16(24)29)18(19,20)21)7-11(9)12-8-26-14(23)13(27-12)15(28)25-6-2-5-22/h3-4,7-8,30H,2,6H2,1H3,(H2,23,26)(H2,24,29)(H,25,28)	LMCDBWSEVFBNFT-UHFFFAOYSA-N	506859	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(2- cyanoethyl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 14::US20250388553, Example 14	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506859&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150961051	459091998							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123700	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCCC#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H17F3N6O3/c1-9-3-4-10(17(30,16(24)29)18(19,20)21)7-11(9)12-8-26-14(23)13(27-12)15(28)25-6-2-5-22/h3-4,7-8,30H,2,6H2,1H3,(H2,23,26)(H2,24,29)(H,25,28)	LMCDBWSEVFBNFT-UHFFFAOYSA-N	506859	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(2- cyanoethyl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 14::US20250388553, Example 14	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506859&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150961051	459091998							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123701	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC(C)(C)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H21F3N6O3/c1-10-4-5-11(19(32,17(26)31)20(21,22)23)6-12(10)13-7-27-15(25)14(29-13)16(30)28-9-18(2,3)8-24/h4-7,32H,9H2,1-3H3,(H2,25,27)(H2,26,31)(H,28,30)	UXSMSJFTJORPRE-UHFFFAOYSA-N	506860	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(2-cyano- 2-methylpropyl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 15::US20250388553, Example 15	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506860&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152086123	459091999							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123702	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC(C)(C)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H21F3N6O3/c1-10-4-5-11(19(32,17(26)31)20(21,22)23)6-12(10)13-7-27-15(25)14(29-13)16(30)28-9-18(2,3)8-24/h4-7,32H,9H2,1-3H3,(H2,25,27)(H2,26,31)(H,28,30)	UXSMSJFTJORPRE-UHFFFAOYSA-N	506860	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(2-cyano- 2-methylpropyl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 15::US20250388553, Example 15	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506860&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152086123	459091999							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123703	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC1(CCC1)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H21F3N6O3/c1-11-3-4-12(20(33,18(27)32)21(22,23)24)7-13(11)14-8-28-16(26)15(30-14)17(31)29-10-19(9-25)5-2-6-19/h3-4,7-8,33H,2,5-6,10H2,1H3,(H2,26,28)(H2,27,32)(H,29,31)	CLSJGMHHAFCOAQ-UHFFFAOYSA-N	506861	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1- cyanocyclobutyl)methyl) pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 16::US20250388553, Example 16	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506861&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149923505	459092000							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123704	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC1(CCC1)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H21F3N6O3/c1-11-3-4-12(20(33,18(27)32)21(22,23)24)7-13(11)14-8-28-16(26)15(30-14)17(31)29-10-19(9-25)5-2-6-19/h3-4,7-8,33H,2,5-6,10H2,1H3,(H2,26,28)(H2,27,32)(H,29,31)	CLSJGMHHAFCOAQ-UHFFFAOYSA-N	506861	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1- cyanocyclobutyl)methyl) pyrazine-2-carboxamide trifluoroacetate::US11046658, Example 16::US20250388553, Example 16	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506861&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149923505	459092000							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123705	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CCC(C)(O)CC2)n1	InChI=1S/C22H26F3N5O4/c1-11-3-4-12(21(34,19(27)32)22(23,24)25)9-14(11)15-10-28-17(26)16(30-15)18(31)29-13-5-7-20(2,33)8-6-13/h3-4,9-10,13,33-34H,5-8H2,1-2H3,(H2,26,28)(H2,27,32)(H,29,31)	DAOPBEFIGQZOLK-UHFFFAOYSA-N	79805	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4-hydroxy-4- methylcyclohexyl)pyrazine- 2-carboxamide trifluoroacetate::US20250388553, Example 17	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79805&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			78488905	252656450							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123706	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CCC(C)(O)CC2)n1	InChI=1S/C22H26F3N5O4/c1-11-3-4-12(21(34,19(27)32)22(23,24)25)9-14(11)15-10-28-17(26)16(30-15)18(31)29-13-5-7-20(2,33)8-6-13/h3-4,9-10,13,33-34H,5-8H2,1-2H3,(H2,26,28)(H2,27,32)(H,29,31)	DAOPBEFIGQZOLK-UHFFFAOYSA-N	79805	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4-hydroxy-4- methylcyclohexyl)pyrazine- 2-carboxamide trifluoroacetate::US20250388553, Example 17	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79805&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			78488905	252656450							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123707	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CCC(O)(C(F)(F)F)CC2)n1	InChI=1S/C22H23F6N5O4/c1-10-2-3-11(20(37,18(30)35)22(26,27)28)8-13(10)14-9-31-16(29)15(33-14)17(34)32-12-4-6-19(36,7-5-12)21(23,24)25/h2-3,8-9,12,36-37H,4-7H2,1H3,(H2,29,31)(H2,30,35)(H,32,34)	DGPIRWITQSIDCP-UHFFFAOYSA-N	79806	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4-hydroxy-4- (trifluoromethyl)cyclohexyl) pyrazine-2-carboxamide trifluoroacetate::US20250388553, Example 18	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79806&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			3239546	252656451							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123708	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CCC(O)(C(F)(F)F)CC2)n1	InChI=1S/C22H23F6N5O4/c1-10-2-3-11(20(37,18(30)35)22(26,27)28)8-13(10)14-9-31-16(29)15(33-14)17(34)32-12-4-6-19(36,7-5-12)21(23,24)25/h2-3,8-9,12,36-37H,4-7H2,1H3,(H2,29,31)(H2,30,35)(H,32,34)	DGPIRWITQSIDCP-UHFFFAOYSA-N	79806	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4-hydroxy-4- (trifluoromethyl)cyclohexyl) pyrazine-2-carboxamide trifluoroacetate::US20250388553, Example 18	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79806&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			3239546	252656451							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123709	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CCC(C(C)(C)O)CC2)n1	InChI=1S/C24H30F3N5O4/c1-12-4-5-14(23(36,21(29)34)24(25,26)27)10-16(12)17-11-30-19(28)18(32-17)20(33)31-15-8-6-13(7-9-15)22(2,3)35/h4-5,10-11,13,15,35-36H,6-9H2,1-3H3,(H2,28,30)(H2,29,34)(H,31,33)	XGDKJUGJTDIFRS-UHFFFAOYSA-N	79807	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4-(2-hydroxypropan-2- yl)cyclohexyl)pyrazine-2- carboxamide trifluoroacetate::US20250388553, Example 19	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79807&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			3244597	252656452							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123710	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CCC(C(C)(C)O)CC2)n1	InChI=1S/C24H30F3N5O4/c1-12-4-5-14(23(36,21(29)34)24(25,26)27)10-16(12)17-11-30-19(28)18(32-17)20(33)31-15-8-6-13(7-9-15)22(2,3)35/h4-5,10-11,13,15,35-36H,6-9H2,1-3H3,(H2,28,30)(H2,29,34)(H,31,33)	XGDKJUGJTDIFRS-UHFFFAOYSA-N	79807	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4-(2-hydroxypropan-2- yl)cyclohexyl)pyrazine-2- carboxamide trifluoroacetate::US20250388553, Example 19	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79807&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			3244597	252656452							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123711	CC[C@@H](CC#N)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C20H21F3N6O3/c1-3-12(6-7-24)28-17(30)15-16(25)27-9-14(29-15)13-8-11(5-4-10(13)2)19(32,18(26)31)20(21,22)23/h4-5,8-9,12,32H,3,6H2,1-2H3,(H2,25,27)(H2,26,31)(H,28,30)	OMXUPFQHXVNNFO-UHFFFAOYSA-N	506865	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)-1- cyanobutan-2-yl)pyrazine- 2-carboxamide trifluoroacetate::US11046658, Example 20::US20250388553, Example 20	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506865&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151353255	459092004							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123712	CC[C@@H](CC#N)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C20H21F3N6O3/c1-3-12(6-7-24)28-17(30)15-16(25)27-9-14(29-15)13-8-11(5-4-10(13)2)19(32,18(26)31)20(21,22)23/h4-5,8-9,12,32H,3,6H2,1-2H3,(H2,25,27)(H2,26,31)(H,28,30)	OMXUPFQHXVNNFO-UHFFFAOYSA-N	506865	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((S)-1- cyanobutan-2-yl)pyrazine- 2-carboxamide trifluoroacetate::US11046658, Example 20::US20250388553, Example 20	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506865&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151353255	459092004							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123713	COC(C)(C)CNC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H24F3N5O4/c1-10-5-6-11(19(31,17(25)30)20(21,22)23)7-12(10)13-8-26-15(24)14(28-13)16(29)27-9-18(2,3)32-4/h5-8,31H,9H2,1-4H3,(H2,24,26)(H2,25,30)(H,27,29)	WVPVYRMYPCUALS-UHFFFAOYSA-N	506866	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(2- methoxy-2- methylpropyl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 21::US20250388553, Example 21	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506866&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152332025	459092005							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123714	COC(C)(C)CNC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H24F3N5O4/c1-10-5-6-11(19(31,17(25)30)20(21,22)23)7-12(10)13-8-26-15(24)14(28-13)16(29)27-9-18(2,3)32-4/h5-8,31H,9H2,1-4H3,(H2,24,26)(H2,25,30)(H,27,29)	WVPVYRMYPCUALS-UHFFFAOYSA-N	506866	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(2- methoxy-2- methylpropyl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 21::US20250388553, Example 21	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506866&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152332025	459092005							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123715	COC1CCC(NC(=O)c2nc(-c3cc(C(O)(C(N)=O)C(F)(F)F)ccc3C)cnc2N)CC1	InChI=1S/C22H26F3N5O4/c1-11-3-4-12(21(33,20(27)32)22(23,24)25)9-15(11)16-10-28-18(26)17(30-16)19(31)29-13-5-7-14(34-2)8-6-13/h3-4,9-10,13-14,33H,5-8H2,1-2H3,(H2,26,28)(H2,27,32)(H,29,31)	XXRUTDXAMYPXSP-UHFFFAOYSA-N	79810	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4- methoxycyclohexyl)pyrazine- 2-carboxamide trifluoroacetate::US20250388553, Example 22	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79810&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			952835	252656455							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123716	COC1CCC(NC(=O)c2nc(-c3cc(C(O)(C(N)=O)C(F)(F)F)ccc3C)cnc2N)CC1	InChI=1S/C22H26F3N5O4/c1-11-3-4-12(21(33,20(27)32)22(23,24)25)9-15(11)16-10-28-18(26)17(30-16)19(31)29-13-5-7-14(34-2)8-6-13/h3-4,9-10,13-14,33H,5-8H2,1-2H3,(H2,26,28)(H2,27,32)(H,29,31)	XXRUTDXAMYPXSP-UHFFFAOYSA-N	79810	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-((1r,4r)- 4- methoxycyclohexyl)pyrazine- 2-carboxamide trifluoroacetate::US20250388553, Example 22	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79810&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			952835	252656455							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123717	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CC(C1)(C2)C#N)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C21H19F3N6O3/c1-10-2-3-11(20(33,17(27)32)21(22,23)24)4-12(10)13-5-28-15(26)14(29-13)16(31)30-19-6-18(7-19,8-19)9-25/h2-5,33H,6-8H2,1H3,(H2,26,28)(H2,27,32)(H,30,31)	IQVYKXSCWZQHTN-UHFFFAOYSA-N	506868	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(3- cyanobicyclo[1.1.1]pentan- 1-yl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 23::US20250388553, Example 23	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506868&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150595972	459092007							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123718	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CC(C1)(C2)C#N)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C21H19F3N6O3/c1-10-2-3-11(20(33,17(27)32)21(22,23)24)4-12(10)13-5-28-15(26)14(29-13)16(31)30-19-6-18(7-19,8-19)9-25/h2-5,33H,6-8H2,1H3,(H2,26,28)(H2,27,32)(H,30,31)	IQVYKXSCWZQHTN-UHFFFAOYSA-N	506868	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(3- cyanobicyclo[1.1.1]pentan- 1-yl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 23::US20250388553, Example 23	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506868&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150595972	459092007							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123719	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CC(C1)(CC2)C#N)C(O)(C(N)=O)C(F)(F)F |r,wU:17.18,(6.58,6.83,;6.58,5.29,;7.91,4.52,;7.91,2.98,;6.58,2.21,;5.25,2.98,;5.25,4.52,;3.91,5.29,;3.91,6.83,;2.58,7.6,;1.24,6.83,;-.09,7.6,;1.24,5.29,;2.58,4.52,;-.09,4.52,;-.09,2.98,;-1.42,5.29,;-2.76,4.52,;-4.16,5.15,;-5.19,4,;-3.86,3.23,;-4.42,2.67,;-2.92,2.99,;-6.73,4.17,;-8.26,4.33,;6.58,.67,;8.12,.67,;6.58,-.87,;5.25,-1.64,;7.91,-1.64,;5.04,.67,;3.5,.67,;5.04,-.87,;5.04,2.21,)|	InChI=1S/C22H21F3N6O3/c1-11-2-3-12(21(34,18(28)33)22(23,24)25)6-13(11)14-7-29-16(27)15(30-14)17(32)31-20-5-4-19(8-20,9-20)10-26/h2-3,6-7,34H,4-5,8-9H2,1H3,(H2,27,29)(H2,28,33)(H,31,32)	BYHJDRWMCCHMJG-UHFFFAOYSA-N	506869	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(4- cyanobicyclo[2.1.1]hexan- 1-yl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 24::US20250388553, Example 24	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506869&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149856691	459092008							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123720	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CC(C1)(CC2)C#N)C(O)(C(N)=O)C(F)(F)F |r,wU:17.18,(6.58,6.83,;6.58,5.29,;7.91,4.52,;7.91,2.98,;6.58,2.21,;5.25,2.98,;5.25,4.52,;3.91,5.29,;3.91,6.83,;2.58,7.6,;1.24,6.83,;-.09,7.6,;1.24,5.29,;2.58,4.52,;-.09,4.52,;-.09,2.98,;-1.42,5.29,;-2.76,4.52,;-4.16,5.15,;-5.19,4,;-3.86,3.23,;-4.42,2.67,;-2.92,2.99,;-6.73,4.17,;-8.26,4.33,;6.58,.67,;8.12,.67,;6.58,-.87,;5.25,-1.64,;7.91,-1.64,;5.04,.67,;3.5,.67,;5.04,-.87,;5.04,2.21,)|	InChI=1S/C22H21F3N6O3/c1-11-2-3-12(21(34,18(28)33)22(23,24)25)6-13(11)14-7-29-16(27)15(30-14)17(32)31-20-5-4-19(8-20,9-20)10-26/h2-3,6-7,34H,4-5,8-9H2,1H3,(H2,27,29)(H2,28,33)(H,31,32)	BYHJDRWMCCHMJG-UHFFFAOYSA-N	506869	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(4- cyanobicyclo[2.1.1]hexan- 1-yl)pyrazine-2- carboxamide trifluoroacetate::US11046658, Example 24::US20250388553, Example 24	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506869&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149856691	459092008							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123721	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC23CCC(C#N)(CC2)CC3)n1	InChI=1S/C24H25F3N6O3/c1-13-2-3-14(23(36,20(30)35)24(25,26)27)10-15(13)16-11-31-18(29)17(32-16)19(34)33-22-7-4-21(12-28,5-8-22)6-9-22/h2-3,10-11,36H,4-9H2,1H3,(H2,29,31)(H2,30,35)(H,33,34)	LUXQNJGKODXYFO-UHFFFAOYSA-N	79813	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(4- cyanobicyclo[2.2.2]octan- 1-yl)pyrazine-2- carboxamide trifluoroacetate::US20250388553, Example 25	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79813&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			5308655	252656458							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123722	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC23CCC(C#N)(CC2)CC3)n1	InChI=1S/C24H25F3N6O3/c1-13-2-3-14(23(36,20(30)35)24(25,26)27)10-15(13)16-11-31-18(29)17(32-16)19(34)33-22-7-4-21(12-28,5-8-22)6-9-22/h2-3,10-11,36H,4-9H2,1H3,(H2,29,31)(H2,30,35)(H,33,34)	LUXQNJGKODXYFO-UHFFFAOYSA-N	79813	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(4- cyanobicyclo[2.2.2]octan- 1-yl)pyrazine-2- carboxamide trifluoroacetate::US20250388553, Example 25	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79813&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			5308655	252656458							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123723	COC[C@H]1CCN1C(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C20H22F3N5O4/c1-10-3-4-11(19(31,18(25)30)20(21,22)23)7-13(10)14-8-26-16(24)15(27-14)17(29)28-6-5-12(28)9-32-2/h3-4,7-8,12,31H,5-6,9H2,1-2H3,(H2,24,26)(H2,25,30)	LPDDCCDIECYMKZ-UHFFFAOYSA-N	506871	2-(3-(5-amino-6-((R)-2- (methoxymethyl)azetidine- 1-carbonyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 26::US20250388553, Example 26	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506871&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150976132	459092010							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123724	COC[C@H]1CCN1C(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C20H22F3N5O4/c1-10-3-4-11(19(31,18(25)30)20(21,22)23)7-13(10)14-8-26-16(24)15(27-14)17(29)28-6-5-12(28)9-32-2/h3-4,7-8,12,31H,5-6,9H2,1-2H3,(H2,24,26)(H2,25,30)	LPDDCCDIECYMKZ-UHFFFAOYSA-N	506871	2-(3-(5-amino-6-((R)-2- (methoxymethyl)azetidine- 1-carbonyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 26::US20250388553, Example 26	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506871&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150976132	459092010							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123725	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N1CCC1(C)C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H22F3N5O3/c1-10-4-5-11(19(31,17(25)30)20(21,22)23)8-12(10)13-9-26-15(24)14(27-13)16(29)28-7-6-18(28,2)3/h4-5,8-9,31H,6-7H2,1-3H3,(H2,24,26)(H2,25,30)	JWAKZHZAARAAPB-UHFFFAOYSA-N	506872	2-(3-(5-amino-6-(2,2- dimethylazetidine-1- carbonyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 27::US20250388553, Example 27	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506872&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150751838	459092011							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123726	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N1CCC1(C)C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H22F3N5O3/c1-10-4-5-11(19(31,17(25)30)20(21,22)23)8-12(10)13-9-26-15(24)14(27-13)16(29)28-7-6-18(28,2)3/h4-5,8-9,31H,6-7H2,1-3H3,(H2,24,26)(H2,25,30)	JWAKZHZAARAAPB-UHFFFAOYSA-N	506872	2-(3-(5-amino-6-(2,2- dimethylazetidine-1- carbonyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 27::US20250388553, Example 27	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506872&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150751838	459092011							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123727	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N1CCc2cccnc12)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H19F3N6O3/c1-11-4-5-13(21(34,20(27)33)22(23,24)25)9-14(11)15-10-29-17(26)16(30-15)19(32)31-8-6-12-3-2-7-28-18(12)31/h2-5,7,9-10,34H,6,8H2,1H3,(H2,26,29)(H2,27,33)	ZAVFYOMTOZJUHA-UHFFFAOYSA-N	506873	2-(3-(5-amino-6-(2,3- dihydro-1H-pyrrolo [2,3-b]pyridine-1- carbonyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 28::US20250388553, Example 28	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506873&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152617534	459092012							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123728	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N1CCc2cccnc12)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H19F3N6O3/c1-11-4-5-13(21(34,20(27)33)22(23,24)25)9-14(11)15-10-29-17(26)16(30-15)19(32)31-8-6-12-3-2-7-28-18(12)31/h2-5,7,9-10,34H,6,8H2,1H3,(H2,26,29)(H2,27,33)	ZAVFYOMTOZJUHA-UHFFFAOYSA-N	506873	2-(3-(5-amino-6-(2,3- dihydro-1H-pyrrolo [2,3-b]pyridine-1- carbonyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 28::US20250388553, Example 28	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506873&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152617534	459092012							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123729	Cc1ccc([C@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CC3CCC2O3)n1	InChI=1S/C21H22F3N5O4/c1-9-2-3-10(20(32,19(26)31)21(22,23)24)6-12(9)14-8-27-17(25)16(28-14)18(30)29-13-7-11-4-5-15(13)33-11/h2-3,6,8,11,13,15,32H,4-5,7H2,1H3,(H2,25,27)(H2,26,31)(H,29,30)	KSTRURISHRYPDX-UHFFFAOYSA-N	79818	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(7- oxabicyclo[2.2.1]heptan-2- yl)pyrazine-2-carboxamide (Peak 1)::US20250388553, Example 29	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79818&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			684860	252656463							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123730	Cc1ccc([C@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CC3CCC2O3)n1	InChI=1S/C21H22F3N5O4/c1-9-2-3-10(20(32,19(26)31)21(22,23)24)6-12(9)14-8-27-17(25)16(28-14)18(30)29-13-7-11-4-5-15(13)33-11/h2-3,6,8,11,13,15,32H,4-5,7H2,1H3,(H2,25,27)(H2,26,31)(H,29,30)	KSTRURISHRYPDX-UHFFFAOYSA-N	79818	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(7- oxabicyclo[2.2.1]heptan-2- yl)pyrazine-2-carboxamide (Peak 1)::US20250388553, Example 29	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79818&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			684860	252656463							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123731	Cc1ccc([C@@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CC3CCC2O3)n1	InChI=1S/C21H22F3N5O4/c1-9-2-3-10(20(32,19(26)31)21(22,23)24)6-12(9)14-8-27-17(25)16(28-14)18(30)29-13-7-11-4-5-15(13)33-11/h2-3,6,8,11,13,15,32H,4-5,7H2,1H3,(H2,25,27)(H2,26,31)(H,29,30)	KSTRURISHRYPDX-UHFFFAOYSA-N	79819	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(7- oxabicyclo[2.2.1]heptan-2- yl)pyrazine-2-carboxamide (Peak 2)::US20250388553, Example 30	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79819&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			3210705	252656464							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123732	Cc1ccc([C@@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NC2CC3CCC2O3)n1	InChI=1S/C21H22F3N5O4/c1-9-2-3-10(20(32,19(26)31)21(22,23)24)6-12(9)14-8-27-17(25)16(28-14)18(30)29-13-7-11-4-5-15(13)33-11/h2-3,6,8,11,13,15,32H,4-5,7H2,1H3,(H2,25,27)(H2,26,31)(H,29,30)	KSTRURISHRYPDX-UHFFFAOYSA-N	79819	3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)-N-(7- oxabicyclo[2.2.1]heptan-2- yl)pyrazine-2-carboxamide (Peak 2)::US20250388553, Example 30	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79819&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			3210705	252656464							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123733	CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(F)F)C(N)=O	InChI=1S/C18H21F2N5O3/c1-8(2)24-15(26)13-14(21)23-7-12(25-13)11-6-10(5-4-9(11)3)18(28,16(19)20)17(22)27/h4-8,16,28H,1-3H3,(H2,21,23)(H2,22,27)(H,24,26)	PPNVJSLGBVLSOL-UHFFFAOYSA-N	506876	US11046658, Example 31::US20250388553, Example 31	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506876&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153389236	459092015							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123734	CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(F)F)C(N)=O	InChI=1S/C18H21F2N5O3/c1-8(2)24-15(26)13-14(21)23-7-12(25-13)11-6-10(5-4-9(11)3)18(28,16(19)20)17(22)27/h4-8,16,28H,1-3H3,(H2,21,23)(H2,22,27)(H,24,26)	PPNVJSLGBVLSOL-UHFFFAOYSA-N	506876	US11046658, Example 31::US20250388553, Example 31	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506876&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153389236	459092015							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123735	CCNC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(F)F)C(N)=O	InChI=1S/C17H19F2N5O3/c1-3-22-14(25)12-13(20)23-7-11(24-12)10-6-9(5-4-8(10)2)17(27,15(18)19)16(21)26/h4-7,15,27H,3H2,1-2H3,(H2,20,23)(H2,21,26)(H,22,25)	ZBQNTVSCYLLZFZ-UHFFFAOYSA-N	506877	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- ethylpyrazine-2- carboxamide::US11046658, Example 32::US20250388553, Example 32	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506877&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152621648	459092016							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123736	CCNC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(F)F)C(N)=O	InChI=1S/C17H19F2N5O3/c1-3-22-14(25)12-13(20)23-7-11(24-12)10-6-9(5-4-8(10)2)17(27,15(18)19)16(21)26/h4-7,15,27H,3H2,1-2H3,(H2,20,23)(H2,21,26)(H,22,25)	ZBQNTVSCYLLZFZ-UHFFFAOYSA-N	506877	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- ethylpyrazine-2- carboxamide::US11046658, Example 32::US20250388553, Example 32	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506877&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152621648	459092016							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123737	Cc1ccc(C(O)(C(N)=O)C(F)F)cc1-c1cnc(N)c(C(=O)NCC2(C#N)CC2)n1	InChI=1S/C20H20F2N6O3/c1-10-2-3-11(20(31,17(21)22)18(25)30)6-12(10)13-7-26-15(24)14(28-13)16(29)27-9-19(8-23)4-5-19/h2-3,6-7,17,31H,4-5,9H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	VQWAKGCKBGPJOE-UHFFFAOYSA-N	79823	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- ((1- cyanocyclopropyl) methyl)pyrazine-2- carboxamide::US20250388553, Example 33	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79823&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			5376739	252656468							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123738	Cc1ccc(C(O)(C(N)=O)C(F)F)cc1-c1cnc(N)c(C(=O)NCC2(C#N)CC2)n1	InChI=1S/C20H20F2N6O3/c1-10-2-3-11(20(31,17(21)22)18(25)30)6-12(10)13-7-26-15(24)14(28-13)16(29)27-9-19(8-23)4-5-19/h2-3,6-7,17,31H,4-5,9H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	VQWAKGCKBGPJOE-UHFFFAOYSA-N	79823	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- ((1- cyanocyclopropyl) methyl)pyrazine-2- carboxamide::US20250388553, Example 33	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79823&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			5376739	252656468							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123739	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCC(F)(F)CC1)C(O)(C(F)F)C(N)=O	InChI=1S/C21H23F4N5O3/c1-10-2-3-11(21(33,18(22)23)19(27)32)8-13(10)14-9-28-16(26)15(30-14)17(31)29-12-4-6-20(24,25)7-5-12/h2-3,8-9,12,18,33H,4-7H2,1H3,(H2,26,28)(H2,27,32)(H,29,31)	GWGDNIAVMRSNCK-UHFFFAOYSA-N	506879	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- (4,4- difluorocyclohexyl) pyrazine-2- carboxamide::US11046658, Example 34::US20250388553, Example 34	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506879&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150363709	459092018							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123740	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCC(F)(F)CC1)C(O)(C(F)F)C(N)=O	InChI=1S/C21H23F4N5O3/c1-10-2-3-11(21(33,18(22)23)19(27)32)8-13(10)14-9-28-16(26)15(30-14)17(31)29-12-4-6-20(24,25)7-5-12/h2-3,8-9,12,18,33H,4-7H2,1H3,(H2,26,28)(H2,27,32)(H,29,31)	GWGDNIAVMRSNCK-UHFFFAOYSA-N	506879	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- (4,4- difluorocyclohexyl) pyrazine-2- carboxamide::US11046658, Example 34::US20250388553, Example 34	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506879&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150363709	459092018							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123741	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC(C)(C)CO)C(O)(C(F)F)C(N)=O	InChI=1S/C19H23F2N5O4/c1-9-4-5-10(19(30,16(20)21)17(23)29)6-11(9)12-7-24-14(22)13(25-12)15(28)26-18(2,3)8-27/h4-7,16,27,30H,8H2,1-3H3,(H2,22,24)(H2,23,29)(H,26,28)	JPKQIIWDCFMPRV-UHFFFAOYSA-N	506880	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- (1-hydroxy-2- methylpropan-2- yl)pyrazine-2- carboxamide::US11046658, Example 35::US20250388553, Example 35	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506880&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150718753	459092019							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123742	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC(C)(C)CO)C(O)(C(F)F)C(N)=O	InChI=1S/C19H23F2N5O4/c1-9-4-5-10(19(30,16(20)21)17(23)29)6-11(9)12-7-24-14(22)13(25-12)15(28)26-18(2,3)8-27/h4-7,16,27,30H,8H2,1-3H3,(H2,22,24)(H2,23,29)(H,26,28)	JPKQIIWDCFMPRV-UHFFFAOYSA-N	506880	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- (1-hydroxy-2- methylpropan-2- yl)pyrazine-2- carboxamide::US11046658, Example 35::US20250388553, Example 35	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506880&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150718753	459092019							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123743	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCOCC1)C(O)(C(F)F)C(N)=O	InChI=1S/C20H23F2N5O4/c1-10-2-3-11(20(30,18(21)22)19(24)29)8-13(10)14-9-25-16(23)15(27-14)17(28)26-12-4-6-31-7-5-12/h2-3,8-9,12,18,30H,4-7H2,1H3,(H2,23,25)(H2,24,29)(H,26,28)	ZHIOBPICEXESTC-UHFFFAOYSA-N	506881	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- (tetrahydro-2H- pyran-4- yl)pyrazine-2- carboxamide::US11046658, Example 36::US20250388553, Example 36	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506881&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152649898	459092020							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123744	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC1CCOCC1)C(O)(C(F)F)C(N)=O	InChI=1S/C20H23F2N5O4/c1-10-2-3-11(20(30,18(21)22)19(24)29)8-13(10)14-9-25-16(23)15(27-14)17(28)26-12-4-6-31-7-5-12/h2-3,8-9,12,18,30H,4-7H2,1H3,(H2,23,25)(H2,24,29)(H,26,28)	ZHIOBPICEXESTC-UHFFFAOYSA-N	506881	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- (tetrahydro-2H- pyran-4- yl)pyrazine-2- carboxamide::US11046658, Example 36::US20250388553, Example 36	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506881&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152649898	459092020							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123745	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCCC1CCOC1)C(O)(C(F)F)C(N)=O	InChI=1S/C21H25F2N5O4/c1-11-2-3-13(21(31,19(22)23)20(25)30)8-14(11)15-9-27-17(24)16(28-15)18(29)26-6-4-12-5-7-32-10-12/h2-3,8-9,12,19,31H,4-7,10H2,1H3,(H2,24,27)(H2,25,30)(H,26,29)	YKFOCYCITABTFH-UHFFFAOYSA-N	506882	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- (2-(tetrahydrofuran- 3-yl)ethyl)pyrazine- 2-carboxamide::US11046658, Example 37::US20250388553, Example 37	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506882&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152534487	459092021							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123746	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCCC1CCOC1)C(O)(C(F)F)C(N)=O	InChI=1S/C21H25F2N5O4/c1-11-2-3-13(21(31,19(22)23)20(25)30)8-14(11)15-9-27-17(24)16(28-15)18(29)26-6-4-12-5-7-32-10-12/h2-3,8-9,12,19,31H,4-7,10H2,1H3,(H2,24,27)(H2,25,30)(H,26,29)	YKFOCYCITABTFH-UHFFFAOYSA-N	506882	3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- oxopropan-2-yl)-2- methylphenyl)-N- (2-(tetrahydrofuran- 3-yl)ethyl)pyrazine- 2-carboxamide::US11046658, Example 37::US20250388553, Example 37	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506882&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152534487	459092021							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123747	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1c2cnc(N)c(C(=O)NCC(F)(F)F)n2	InChI=1S/C17H15F6N5O3/c1-7-2-3-8(16(31,14(25)30)17(21,22)23)4-9(7)10-5-26-12(24)11(28-10)13(29)27-6-15(18,19)20/h2-5,31H,6H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	KEOXILFBGBQPLF-UHFFFAOYSA-N	95662	US20250388553, Example 38	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95662&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			122723	164036906							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123748	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1c2cnc(N)c(C(=O)NCC(F)(F)F)n2	InChI=1S/C17H15F6N5O3/c1-7-2-3-8(16(31,14(25)30)17(21,22)23)4-9(7)10-5-26-12(24)11(28-10)13(29)27-6-15(18,19)20/h2-5,31H,6H2,1H3,(H2,24,26)(H2,25,30)(H,27,29)	KEOXILFBGBQPLF-UHFFFAOYSA-N	95662	US20250388553, Example 38	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95662	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95662&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			122723	164036906							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123749	CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(CNC(C)=O)C(F)(F)F	InChI=1S/C20H24F3N5O3/c1-10(2)27-18(30)16-17(24)25-8-15(28-16)14-7-13(6-5-11(14)3)19(31,20(21,22)23)9-26-12(4)29/h5-8,10,31H,9H2,1-4H3,(H2,24,25)(H,26,29)(H,27,30)	GNSVXIGOWREOGQ-UHFFFAOYSA-N	506884	US11046658, Example 39::US20250388553, Example 39	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506884&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150321545	459092023							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123750	CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(CNC(C)=O)C(F)(F)F	InChI=1S/C20H24F3N5O3/c1-10(2)27-18(30)16-17(24)25-8-15(28-16)14-7-13(6-5-11(14)3)19(31,20(21,22)23)9-26-12(4)29/h5-8,10,31H,9H2,1-4H3,(H2,24,25)(H,26,29)(H,27,30)	GNSVXIGOWREOGQ-UHFFFAOYSA-N	506884	US11046658, Example 39::US20250388553, Example 39	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506884&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150321545	459092023							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123751	N#CCC(=O)NCC(O)(c1ccc(C)c(-c2cnc(N)c(C(=O)NC(C)C)n2)c1)C(F)(F)F	InChI=1S/C21H23F3N6O3/c1-11(2)29-19(32)17-18(26)27-9-15(30-17)14-8-13(5-4-12(14)3)20(33,21(22,23)24)10-28-16(31)6-7-25/h4-5,8-9,11,33H,6,10H2,1-3H3,(H2,26,27)(H,28,31)(H,29,32)	UFSRTDMMLDLPLU-UHFFFAOYSA-N	79830	US20250388553, Example 40	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79830&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			3493951	252656475							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123752	N#CCC(=O)NCC(O)(c1ccc(C)c(-c2cnc(N)c(C(=O)NC(C)C)n2)c1)C(F)(F)F	InChI=1S/C21H23F3N6O3/c1-11(2)29-19(32)17-18(26)27-9-15(30-17)14-8-13(5-4-12(14)3)20(33,21(22,23)24)10-28-16(31)6-7-25/h4-5,8-9,11,33H,6,10H2,1-3H3,(H2,26,27)(H,28,31)(H,29,32)	UFSRTDMMLDLPLU-UHFFFAOYSA-N	79830	US20250388553, Example 40	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79830	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79830&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			3493951	252656475							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123753	CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(CNC(=O)C(C)(C)O)C(F)(F)F	InChI=1S/C22H28F3N5O4/c1-11(2)29-18(31)16-17(26)27-9-15(30-16)14-8-13(7-6-12(14)3)21(34,22(23,24)25)10-28-19(32)20(4,5)33/h6-9,11,33-34H,10H2,1-5H3,(H2,26,27)(H,28,32)(H,29,31)	YWEXURQOKDKMKE-UHFFFAOYSA-N	506886	US11046658, Example 41::US20250388553, Example 41	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506886&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152594642	459092025							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123754	CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(CNC(=O)C(C)(C)O)C(F)(F)F	InChI=1S/C22H28F3N5O4/c1-11(2)29-18(31)16-17(26)27-9-15(30-16)14-8-13(7-6-12(14)3)21(34,22(23,24)25)10-28-19(32)20(4,5)33/h6-9,11,33-34H,10H2,1-5H3,(H2,26,27)(H,28,32)(H,29,31)	YWEXURQOKDKMKE-UHFFFAOYSA-N	506886	US11046658, Example 41::US20250388553, Example 41	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506886&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152594642	459092025							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123755	N#CCC(=O)NCC(O)(c1ccc(C)c(-c2cnc(N)c(C(=O)NC(C)C)n2)c1)C(F)(F)F	InChI=1S/C21H23F3N6O3/c1-11(2)29-19(32)17-18(26)27-9-15(30-17)14-8-13(5-4-12(14)3)20(33,21(22,23)24)10-28-16(31)6-7-25/h4-5,8-9,11,33H,6,10H2,1-3H3,(H2,26,27)(H,28,31)(H,29,32)	UFSRTDMMLDLPLU-UHFFFAOYSA-N	79832	US20250388553, Example 42	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79832&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			2121796	252656477							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123756	N#CCC(=O)NCC(O)(c1ccc(C)c(-c2cnc(N)c(C(=O)NC(C)C)n2)c1)C(F)(F)F	InChI=1S/C21H23F3N6O3/c1-11(2)29-19(32)17-18(26)27-9-15(30-17)14-8-13(5-4-12(14)3)20(33,21(22,23)24)10-28-16(31)6-7-25/h4-5,8-9,11,33H,6,10H2,1-3H3,(H2,26,27)(H,28,31)(H,29,32)	UFSRTDMMLDLPLU-UHFFFAOYSA-N	79832	US20250388553, Example 42	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79832&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			2121796	252656477							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123757	Cc1ccc([C@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NCC(O)C(F)(F)F)n1	InChI=1S/C18H17F6N5O4/c1-7-2-3-8(16(33,15(26)32)18(22,23)24)4-9(7)10-5-27-13(25)12(29-10)14(31)28-6-11(30)17(19,20)21/h2-5,11,30,33H,6H2,1H3,(H2,25,27)(H2,26,32)(H,28,31)	WFPRGQZILLAXQE-UHFFFAOYSA-N	79833	3-amino-6-(5-(3-amino-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl)-2-methylphenyl)-N-(3,3,3-trifluoro-2-hydroxypropyl)pyrazine-2-carboxamide::US20250388553, Example 43A	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79833&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			4877213	252656478							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123758	Cc1ccc([C@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NCC(O)C(F)(F)F)n1	InChI=1S/C18H17F6N5O4/c1-7-2-3-8(16(33,15(26)32)18(22,23)24)4-9(7)10-5-27-13(25)12(29-10)14(31)28-6-11(30)17(19,20)21/h2-5,11,30,33H,6H2,1H3,(H2,25,27)(H2,26,32)(H,28,31)	WFPRGQZILLAXQE-UHFFFAOYSA-N	79833	3-amino-6-(5-(3-amino-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl)-2-methylphenyl)-N-(3,3,3-trifluoro-2-hydroxypropyl)pyrazine-2-carboxamide::US20250388553, Example 43A	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79833&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			4877213	252656478							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123759	Cc1ccc([C@@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NCC(O)C(F)(F)F)n1	InChI=1S/C18H17F6N5O4/c1-7-2-3-8(16(33,15(26)32)18(22,23)24)4-9(7)10-5-27-13(25)12(29-10)14(31)28-6-11(30)17(19,20)21/h2-5,11,30,33H,6H2,1H3,(H2,25,27)(H2,26,32)(H,28,31)	WFPRGQZILLAXQE-UHFFFAOYSA-N	79834	US20250388553, Example 43B	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79834&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			1012499	252656479							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123760	Cc1ccc([C@@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C(=O)NCC(O)C(F)(F)F)n1	InChI=1S/C18H17F6N5O4/c1-7-2-3-8(16(33,15(26)32)18(22,23)24)4-9(7)10-5-27-13(25)12(29-10)14(31)28-6-11(30)17(19,20)21/h2-5,11,30,33H,6H2,1H3,(H2,25,27)(H2,26,32)(H,28,31)	WFPRGQZILLAXQE-UHFFFAOYSA-N	79834	US20250388553, Example 43B	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79834&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			1012499	252656479							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123761	C\C=C/c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H17F3N4O2/c1-3-4-12-14(21)23-8-13(24-12)11-7-10(6-5-9(11)2)16(26,15(22)25)17(18,19)20/h3-8,26H,1-2H3,(H2,21,23)(H2,22,25)	XNQXJDDKFKVLNA-UHFFFAOYSA-N	506890	US11046658, Example 44::US20250388553, Example 44	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506890&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152421996	459092028							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123762	C\C=C/c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H17F3N4O2/c1-3-4-12-14(21)23-8-13(24-12)11-7-10(6-5-9(11)2)16(26,15(22)25)17(18,19)20/h3-8,26H,1-2H3,(H2,21,23)(H2,22,25)	XNQXJDDKFKVLNA-UHFFFAOYSA-N	506890	US11046658, Example 44::US20250388553, Example 44	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506890&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152421996	459092028							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123763	CCCc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H19F3N4O2/c1-3-4-12-14(21)23-8-13(24-12)11-7-10(6-5-9(11)2)16(26,15(22)25)17(18,19)20/h5-8,26H,3-4H2,1-2H3,(H2,21,23)(H2,22,25)	NNQPDRGEWIIUBT-UHFFFAOYSA-N	506891	US11046658, Example 45::US20250388553, Example 45	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506891&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151227882	459092029							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123764	CCCc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H19F3N4O2/c1-3-4-12-14(21)23-8-13(24-12)11-7-10(6-5-9(11)2)16(26,15(22)25)17(18,19)20/h5-8,26H,3-4H2,1-2H3,(H2,21,23)(H2,22,25)	NNQPDRGEWIIUBT-UHFFFAOYSA-N	506891	US11046658, Example 45::US20250388553, Example 45	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506891&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151227882	459092029							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123765	Cc1ccc(cc1-c1cnc(N)c(n1)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C15H12F6N4O2/c1-6-2-3-7(13(27,12(23)26)15(19,20)21)4-8(6)9-5-24-11(22)10(25-9)14(16,17)18/h2-5,27H,1H3,(H2,22,24)(H2,23,26)	JVLWRUDKSWJRKT-UHFFFAOYSA-N	506892	US11046658, Example 46::US20250388553, Example 46	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506892&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150749070	459092030							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123766	Cc1ccc(cc1-c1cnc(N)c(n1)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C15H12F6N4O2/c1-6-2-3-7(13(27,12(23)26)15(19,20)21)4-8(6)9-5-24-11(22)10(25-9)14(16,17)18/h2-5,27H,1H3,(H2,22,24)(H2,23,26)	JVLWRUDKSWJRKT-UHFFFAOYSA-N	506892	US11046658, Example 46::US20250388553, Example 46	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506892&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150749070	459092030							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123767	COCC#Cc2nc(c1cc(C(O)(C(N)=O)C(F)(F)F)ccc1C)cnc2N	InChI=1S/C18H17F3N4O3/c1-10-5-6-11(17(27,16(23)26)18(19,20)21)8-12(10)14-9-24-15(22)13(25-14)4-3-7-28-2/h5-6,8-9,27H,7H2,1-2H3,(H2,22,24)(H2,23,26)	YCWHKVNGDYMUKS-UHFFFAOYSA-N	79838	US20250388553, Example 47	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79838&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			5765374	252656483							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123768	COCC#Cc2nc(c1cc(C(O)(C(N)=O)C(F)(F)F)ccc1C)cnc2N	InChI=1S/C18H17F3N4O3/c1-10-5-6-11(17(27,16(23)26)18(19,20)21)8-12(10)14-9-24-15(22)13(25-14)4-3-7-28-2/h5-6,8-9,27H,7H2,1-2H3,(H2,22,24)(H2,23,26)	YCWHKVNGDYMUKS-UHFFFAOYSA-N	79838	US20250388553, Example 47	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79838&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			5765374	252656483							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123769	Cc1ccc(cc1-c1cnc(N)c(n1)C#CC1CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H17F3N4O2/c1-10-2-6-12(18(28,17(24)27)19(20,21)22)8-13(10)15-9-25-16(23)14(26-15)7-5-11-3-4-11/h2,6,8-9,11,28H,3-4H2,1H3,(H2,23,25)(H2,24,27)	XBSOUSPSUYHAGX-UHFFFAOYSA-N	506894	2-(3-(5-amino-6- (cyclopropylethynyl)pyrazin- 2-yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 48::US20250388553, Example 48	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506894&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152362534	459092032							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123770	Cc1ccc(cc1-c1cnc(N)c(n1)C#CC1CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H17F3N4O2/c1-10-2-6-12(18(28,17(24)27)19(20,21)22)8-13(10)15-9-25-16(23)14(26-15)7-5-11-3-4-11/h2,6,8-9,11,28H,3-4H2,1H3,(H2,23,25)(H2,24,27)	XBSOUSPSUYHAGX-UHFFFAOYSA-N	506894	2-(3-(5-amino-6- (cyclopropylethynyl)pyrazin- 2-yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 48::US20250388553, Example 48	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506894&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152362534	459092032							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123771	CC(C)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H19F3N4O2/c1-10(2)4-7-14-16(23)25-9-15(26-14)13-8-12(6-5-11(13)3)18(28,17(24)27)19(20,21)22/h5-6,8-10,28H,1-3H3,(H2,23,25)(H2,24,27)	QTBGVZHXINBLDN-UHFFFAOYSA-N	506895	2-(3-(5-amino-6-(3-methylbut- 1-ynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 49::US20250388553, Example 49	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506895&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151643678	459092033							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123772	CC(C)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H19F3N4O2/c1-10(2)4-7-14-16(23)25-9-15(26-14)13-8-12(6-5-11(13)3)18(28,17(24)27)19(20,21)22/h5-6,8-10,28H,1-3H3,(H2,23,25)(H2,24,27)	QTBGVZHXINBLDN-UHFFFAOYSA-N	506895	2-(3-(5-amino-6-(3-methylbut- 1-ynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 49::US20250388553, Example 49	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506895&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151643678	459092033							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123773	Cc1ccc(cc1-c1cnc(N)c(n1)C#CC(C)(C)O)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H19F3N4O3/c1-10-4-5-11(18(29,16(24)27)19(20,21)22)8-12(10)14-9-25-15(23)13(26-14)6-7-17(2,3)28/h4-5,8-9,28-29H,1-3H3,(H2,23,25)(H2,24,27)	OYIHKVMTYRPIET-UHFFFAOYSA-N	506896	2-(3-(5-amino-6-(3-hydroxy-3- methylbut-1-ynyl)pyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 50::US20250388553, Example 50	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506896&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151410112	459092034							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123774	Cc1ccc(cc1-c1cnc(N)c(n1)C#CC(C)(C)O)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H19F3N4O3/c1-10-4-5-11(18(29,16(24)27)19(20,21)22)8-12(10)14-9-25-15(23)13(26-14)6-7-17(2,3)28/h4-5,8-9,28-29H,1-3H3,(H2,23,25)(H2,24,27)	OYIHKVMTYRPIET-UHFFFAOYSA-N	506896	2-(3-(5-amino-6-(3-hydroxy-3- methylbut-1-ynyl)pyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 50::US20250388553, Example 50	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506896&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151410112	459092034							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123775	CC(O)CC#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H19F3N4O3/c1-10-6-7-12(18(29,17(24)28)19(20,21)22)8-13(10)15-9-25-16(23)14(26-15)5-3-4-11(2)27/h6-9,11,27,29H,4H2,1-2H3,(H2,23,25)(H2,24,28)	SFTOUDPUOPTXDM-UHFFFAOYSA-N	506897	2-(3-(5-amino-6-(4- hydroxypent-1-ynyl)pyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 51::US20250388553, Example 51	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506897&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151836507	459092035							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123776	CC(O)CC#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H19F3N4O3/c1-10-6-7-12(18(29,17(24)28)19(20,21)22)8-13(10)15-9-25-16(23)14(26-15)5-3-4-11(2)27/h6-9,11,27,29H,4H2,1-2H3,(H2,23,25)(H2,24,28)	SFTOUDPUOPTXDM-UHFFFAOYSA-N	506897	2-(3-(5-amino-6-(4- hydroxypent-1-ynyl)pyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 51::US20250388553, Example 51	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506897&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151836507	459092035							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123777	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccn[nH]1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H15F3N6O2/c1-10-2-3-11(18(30,17(24)29)19(20,21)22)8-13(10)15-9-25-16(23)14(27-15)5-4-12-6-7-26-28-12/h2-3,6-9,30H,1H3,(H2,23,25)(H2,24,29)(H,26,28)	NVMDHIBEHQCVNE-UHFFFAOYSA-N	506898	2-(3-(6-((1H-pyrazol-5- yl)ethynyl)-5-aminopyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 52::US20250388553, Example 52	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506898&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305419	459092036							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123778	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccn[nH]1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H15F3N6O2/c1-10-2-3-11(18(30,17(24)29)19(20,21)22)8-13(10)15-9-25-16(23)14(27-15)5-4-12-6-7-26-28-12/h2-3,6-9,30H,1H3,(H2,23,25)(H2,24,29)(H,26,28)	NVMDHIBEHQCVNE-UHFFFAOYSA-N	506898	2-(3-(6-((1H-pyrazol-5- yl)ethynyl)-5-aminopyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 52::US20250388553, Example 52	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506898&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305419	459092036							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123779	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cncn1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H17F3N6O2/c1-11-3-4-12(19(31,18(25)30)20(21,22)23)7-14(11)16-9-27-17(24)15(28-16)6-5-13-8-26-10-29(13)2/h3-4,7-10,31H,1-2H3,(H2,24,27)(H2,25,30)	TVTCHCPTITYJOZ-UHFFFAOYSA-N	506899	2-(3-(5-amino-6-((1-methyl- 1H-imidazol-5- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 53::US20250388553, Example 53	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506899&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151946450	459092037							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123780	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cncn1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H17F3N6O2/c1-11-3-4-12(19(31,18(25)30)20(21,22)23)7-14(11)16-9-27-17(24)15(28-16)6-5-13-8-26-10-29(13)2/h3-4,7-10,31H,1-2H3,(H2,24,27)(H2,25,30)	TVTCHCPTITYJOZ-UHFFFAOYSA-N	506899	2-(3-(5-amino-6-((1-methyl- 1H-imidazol-5- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 53::US20250388553, Example 53	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506899&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151946450	459092037							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123781	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H17F3N6O2/c1-11-3-5-13(19(31,18(25)30)20(21,22)23)7-14(11)16-9-26-17(24)15(28-16)6-4-12-8-27-29(2)10-12/h3,5,7-10,31H,1-2H3,(H2,24,26)(H2,25,30)	YLCPYBKXGQBIOB-UHFFFAOYSA-N	506900	2-(3-(5-amino-6-((1-methyl- 1H-pyrazol-4- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 54::US20250388553, Example 54	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506900&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152538879	459092038							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123782	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H17F3N6O2/c1-11-3-5-13(19(31,18(25)30)20(21,22)23)7-14(11)16-9-26-17(24)15(28-16)6-4-12-8-27-29(2)10-12/h3,5,7-10,31H,1-2H3,(H2,24,26)(H2,25,30)	YLCPYBKXGQBIOB-UHFFFAOYSA-N	506900	2-(3-(5-amino-6-((1-methyl- 1H-pyrazol-4- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 54::US20250388553, Example 54	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506900&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152538879	459092038							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123783	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccccn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H16F3N5O2/c1-12-5-6-13(20(31,19(26)30)21(22,23)24)10-15(12)17-11-28-18(25)16(29-17)8-7-14-4-2-3-9-27-14/h2-6,9-11,31H,1H3,(H2,25,28)(H2,26,30)	NNPSXFFFVYGJII-UHFFFAOYSA-N	506901	2-(3-(5-amino-6-(pyridin-2- ylethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 55::US20250388553, Example 55	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506901&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305449	459092039							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123784	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccccn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H16F3N5O2/c1-12-5-6-13(20(31,19(26)30)21(22,23)24)10-15(12)17-11-28-18(25)16(29-17)8-7-14-4-2-3-9-27-14/h2-6,9-11,31H,1H3,(H2,25,28)(H2,26,30)	NNPSXFFFVYGJII-UHFFFAOYSA-N	506901	2-(3-(5-amino-6-(pyridin-2- ylethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 55::US20250388553, Example 55	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506901&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305449	459092039							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123785	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cncnc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H15F3N6O2/c1-11-2-4-13(19(31,18(25)30)20(21,22)23)6-14(11)16-9-28-17(24)15(29-16)5-3-12-7-26-10-27-8-12/h2,4,6-10,31H,1H3,(H2,24,28)(H2,25,30)	IWBXVTNOQYESNT-UHFFFAOYSA-N	506902	2-(3-(5-amino-6-(pyrimidin-5- ylethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 56::US20250388553, Example 56	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506902&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150621923	459092040							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123786	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cncnc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H15F3N6O2/c1-11-2-4-13(19(31,18(25)30)20(21,22)23)6-14(11)16-9-28-17(24)15(29-16)5-3-12-7-26-10-27-8-12/h2,4,6-10,31H,1H3,(H2,24,28)(H2,25,30)	IWBXVTNOQYESNT-UHFFFAOYSA-N	506902	2-(3-(5-amino-6-(pyrimidin-5- ylethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 56::US20250388553, Example 56	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506902&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150621923	459092040							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123787	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cnccn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H15F3N6O2/c1-11-2-3-12(19(31,18(25)30)20(21,22)23)8-14(11)16-10-28-17(24)15(29-16)5-4-13-9-26-6-7-27-13/h2-3,6-10,31H,1H3,(H2,24,28)(H2,25,30)	ZWPPNYPDAMLXFL-UHFFFAOYSA-N	506903	2-(3-(5-amino-6-(pyrazin-2- ylethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 57::US20250388553, Example 57	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506903&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152726015	459092041							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123788	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cnccn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H15F3N6O2/c1-11-2-3-12(19(31,18(25)30)20(21,22)23)8-14(11)16-10-28-17(24)15(29-16)5-4-13-9-26-6-7-27-13/h2-3,6-10,31H,1H3,(H2,24,28)(H2,25,30)	ZWPPNYPDAMLXFL-UHFFFAOYSA-N	506903	2-(3-(5-amino-6-(pyrazin-2- ylethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 57::US20250388553, Example 57	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506903&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152726015	459092041							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123789	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccc(cc1)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H16F3N5O2/c1-13-2-8-16(22(33,21(29)32)23(24,25)26)10-17(13)19-12-30-20(28)18(31-19)9-7-14-3-5-15(11-27)6-4-14/h2-6,8,10,12,33H,1H3,(H2,28,30)(H2,29,32)	ZBAWLNGKGNJUBT-UHFFFAOYSA-N	506904	2-(3-(5-amino-6-((4- cyanophenyl)ethynyl)pyrazin- 2-yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 58::US20250388553, Example 58	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506904&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152618617	459092042							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123790	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccc(cc1)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H16F3N5O2/c1-13-2-8-16(22(33,21(29)32)23(24,25)26)10-17(13)19-12-30-20(28)18(31-19)9-7-14-3-5-15(11-27)6-4-14/h2-6,8,10,12,33H,1H3,(H2,28,30)(H2,29,32)	ZBAWLNGKGNJUBT-UHFFFAOYSA-N	506904	2-(3-(5-amino-6-((4- cyanophenyl)ethynyl)pyrazin- 2-yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 58::US20250388553, Example 58	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506904	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506904&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152618617	459092042							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123791	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccc(CC#N)cc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C24H18F3N5O2/c1-14-2-8-17(23(34,22(30)33)24(25,26)27)12-18(14)20-13-31-21(29)19(32-20)9-7-15-3-5-16(6-4-15)10-11-28/h2-6,8,12-13,34H,10H2,1H3,(H2,29,31)(H2,30,33)	ODFYQEHODGTUOX-UHFFFAOYSA-N	506905	2-(3-(5-amino-6-((4- (cyanomethyl)phenyl)ethynyl) pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 59::US20250388553, Example 59	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506905&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151305155	459092043					C04116		1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123792	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccc(CC#N)cc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C24H18F3N5O2/c1-14-2-8-17(23(34,22(30)33)24(25,26)27)12-18(14)20-13-31-21(29)19(32-20)9-7-15-3-5-16(6-4-15)10-11-28/h2-6,8,12-13,34H,10H2,1H3,(H2,29,31)(H2,30,33)	ODFYQEHODGTUOX-UHFFFAOYSA-N	506905	2-(3-(5-amino-6-((4- (cyanomethyl)phenyl)ethynyl) pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 59::US20250388553, Example 59	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506905&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151305155	459092043					C04116		1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123793	COc1cc(OC)cc(c1)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C24H21F3N4O4/c1-13-4-6-15(23(33,22(29)32)24(25,26)27)10-18(13)20-12-30-21(28)19(31-20)7-5-14-8-16(34-2)11-17(9-14)35-3/h4,6,8-12,33H,1-3H3,(H2,28,30)(H2,29,32)	WXJLSRBTPQQANX-UHFFFAOYSA-N	506906	2-(3-(5-amino-6-((3,5- dimethoxyphenyl)ethynyl)pyra zin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide::US11046658, Example 60::US20250388553, Example 60	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506906&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305467	459092044							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123794	COc1cc(OC)cc(c1)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C24H21F3N4O4/c1-13-4-6-15(23(33,22(29)32)24(25,26)27)10-18(13)20-12-30-21(28)19(31-20)7-5-14-8-16(34-2)11-17(9-14)35-3/h4,6,8-12,33H,1-3H3,(H2,28,30)(H2,29,32)	WXJLSRBTPQQANX-UHFFFAOYSA-N	506906	2-(3-(5-amino-6-((3,5- dimethoxyphenyl)ethynyl)pyra zin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide::US11046658, Example 60::US20250388553, Example 60	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506906&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305467	459092044							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123795	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cccc(F)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H16F4N4O2/c1-12-5-7-14(21(32,20(28)31)22(24,25)26)10-16(12)18-11-29-19(27)17(30-18)8-6-13-3-2-4-15(23)9-13/h2-5,7,9-11,32H,1H3,(H2,27,29)(H2,28,31)	RHZGJLAATSRUHA-UHFFFAOYSA-N	506907	2-(3-(5-amino-6-((3- fluorophenyl)ethynyl)pyrazin- 2-yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 61::US20250388553, Example 61	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506907&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151718095	459092045							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123796	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cccc(F)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H16F4N4O2/c1-12-5-7-14(21(32,20(28)31)22(24,25)26)10-16(12)18-11-29-19(27)17(30-18)8-6-13-3-2-4-15(23)9-13/h2-5,7,9-11,32H,1H3,(H2,27,29)(H2,28,31)	RHZGJLAATSRUHA-UHFFFAOYSA-N	506907	2-(3-(5-amino-6-((3- fluorophenyl)ethynyl)pyrazin- 2-yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide::US11046658, Example 61::US20250388553, Example 61	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506907&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151718095	459092045							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123797	CC(C)C(C)(O)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H23F3N4O3/c1-11(2)19(4,30)8-7-15-17(25)27-10-16(28-15)14-9-13(6-5-12(14)3)20(31,18(26)29)21(22,23)24/h5-6,9-11,30-31H,1-4H3,(H2,25,27)(H2,26,29)	YEBSHWGNEJWRAC-UHFFFAOYSA-N	506908	2-(3-(5-amino-6-(3-hydroxy- 3,4-dimethylpent-1- ynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 62::US20250388553, Example 62	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506908&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305453	459092046							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123798	CC(C)C(C)(O)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H23F3N4O3/c1-11(2)19(4,30)8-7-15-17(25)27-10-16(28-15)14-9-13(6-5-12(14)3)20(31,18(26)29)21(22,23)24/h5-6,9-11,30-31H,1-4H3,(H2,25,27)(H2,26,29)	YEBSHWGNEJWRAC-UHFFFAOYSA-N	506908	2-(3-(5-amino-6-(3-hydroxy- 3,4-dimethylpent-1- ynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 62::US20250388553, Example 62	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506908&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305453	459092046							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123799	Cc1ccc(cc1-c1cnc(N)c(n1)C#CC1CCOCC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H21F3N4O3/c1-12-2-4-14(20(30,19(26)29)21(22,23)24)10-15(12)17-11-27-18(25)16(28-17)5-3-13-6-8-31-9-7-13/h2,4,10-11,13,30H,6-9H2,1H3,(H2,25,27)(H2,26,29)	ZWVNUBRZSYRECK-UHFFFAOYSA-N	506909	2-(3-(5-amino-6-((tetrahydro- 2H-pyran-4- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 63::US20250388553, Example 63	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506909&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305415	459092047							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123800	Cc1ccc(cc1-c1cnc(N)c(n1)C#CC1CCOCC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H21F3N4O3/c1-12-2-4-14(20(30,19(26)29)21(22,23)24)10-15(12)17-11-27-18(25)16(28-17)5-3-13-6-8-31-9-7-13/h2,4,10-11,13,30H,6-9H2,1H3,(H2,25,27)(H2,26,29)	ZWVNUBRZSYRECK-UHFFFAOYSA-N	506909	2-(3-(5-amino-6-((tetrahydro- 2H-pyran-4- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 63::US20250388553, Example 63	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506909&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305415	459092047							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123801	Cc1ccc(cc1-c1cnc(N)c(n1)C#CC1(C)CCOCC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H23F3N4O3/c1-13-3-4-14(21(31,19(27)30)22(23,24)25)11-15(13)17-12-28-18(26)16(29-17)5-6-20(2)7-9-32-10-8-20/h3-4,11-12,31H,7-10H2,1-2H3,(H2,26,28)(H2,27,30)	AIOKRZZFNZIMBU-UHFFFAOYSA-N	506910	2-(3-(5-amino-6-((4- methyltetrahydro-2H-pyran-4- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 64::US20250388553, Example 64	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506910&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149648297	459092048							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123802	Cc1ccc(cc1-c1cnc(N)c(n1)C#CC1(C)CCOCC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H23F3N4O3/c1-13-3-4-14(21(31,19(27)30)22(23,24)25)11-15(13)17-12-28-18(26)16(29-17)5-6-20(2)7-9-32-10-8-20/h3-4,11-12,31H,7-10H2,1-2H3,(H2,26,28)(H2,27,30)	AIOKRZZFNZIMBU-UHFFFAOYSA-N	506910	2-(3-(5-amino-6-((4- methyltetrahydro-2H-pyran-4- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 64::US20250388553, Example 64	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506910&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149648297	459092048							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123803	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C#CC2(O)CCN(C)C2=O)n1	InChI=1S/C21H20F3N5O4/c1-11-3-4-12(20(33,17(26)30)21(22,23)24)9-13(11)15-10-27-16(25)14(28-15)5-6-19(32)7-8-29(2)18(19)31/h3-4,9-10,32-33H,7-8H2,1-2H3,(H2,25,27)(H2,26,30)	FAQWWUUIAXQUQI-UHFFFAOYSA-N	79856	2-(3-(5-amino-6-((3-hydroxy- 1-methyl-2-oxopyrrolidin-3- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-::US20250388553, Example 65	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79856&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			5521669	252656501							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123804	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(C#CC2(O)CCN(C)C2=O)n1	InChI=1S/C21H20F3N5O4/c1-11-3-4-12(20(33,17(26)30)21(22,23)24)9-13(11)15-10-27-16(25)14(28-15)5-6-19(32)7-8-29(2)18(19)31/h3-4,9-10,32-33H,7-8H2,1-2H3,(H2,25,27)(H2,26,30)	FAQWWUUIAXQUQI-UHFFFAOYSA-N	79856	2-(3-(5-amino-6-((3-hydroxy- 1-methyl-2-oxopyrrolidin-3- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-::US20250388553, Example 65	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79856&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			5521669	252656501							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123805	Cc1cnc(cn1)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H17F3N6O2/c1-11-3-4-13(20(32,19(26)31)21(22,23)24)7-15(11)17-10-29-18(25)16(30-17)6-5-14-9-27-12(2)8-28-14/h3-4,7-10,32H,1-2H3,(H2,25,29)(H2,26,31)	GVNSGNHMXAORRJ-UHFFFAOYSA-N	506912	2-(3-(5-amino-6-((5- methylpyrazin-2- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 66::US20250388553, Example 66	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506912&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305470	459092050							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123806	Cc1cnc(cn1)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H17F3N6O2/c1-11-3-4-13(20(32,19(26)31)21(22,23)24)7-15(11)17-10-29-18(25)16(30-17)6-5-14-9-27-12(2)8-28-14/h3-4,7-10,32H,1-2H3,(H2,25,29)(H2,26,31)	GVNSGNHMXAORRJ-UHFFFAOYSA-N	506912	2-(3-(5-amino-6-((5- methylpyrazin-2- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 66::US20250388553, Example 66	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506912&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305470	459092050							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123807	COc1cnc(cn1)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H17F3N6O3/c1-11-3-4-12(20(32,19(26)31)21(22,23)24)7-14(11)16-9-29-18(25)15(30-16)6-5-13-8-28-17(33-2)10-27-13/h3-4,7-10,32H,1-2H3,(H2,25,29)(H2,26,31)	JSPIARUROFGUCD-UHFFFAOYSA-N	506913	2-(3-(5-amino-6-((5- methoxypyrazin-2- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 67::US20250388553, Example 67	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506913&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305425	459092051							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123808	COc1cnc(cn1)C#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H17F3N6O3/c1-11-3-4-12(20(32,19(26)31)21(22,23)24)7-14(11)16-9-29-18(25)15(30-16)6-5-13-8-28-17(33-2)10-27-13/h3-4,7-10,32H,1-2H3,(H2,25,29)(H2,26,31)	JSPIARUROFGUCD-UHFFFAOYSA-N	506913	2-(3-(5-amino-6-((5- methoxypyrazin-2- yl)ethynyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro- 2-hydroxypropanamide::US11046658, Example 67::US20250388553, Example 67	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506913&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305425	459092051							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123809	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cn2ccnc2cn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H16F3N7O2/c1-12-2-3-13(21(34,20(27)33)22(23,24)25)8-15(12)17-9-30-19(26)16(31-17)5-4-14-11-32-7-6-28-18(32)10-29-14/h2-3,6-11,34H,1H3,(H2,26,30)(H2,27,33)	YRHFFZSGYDMXFD-UHFFFAOYSA-N	506914	US11046658, Example 68++::US20250388553, Example 68	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506914&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305457	459092052							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123810	Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cn2ccnc2cn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H16F3N7O2/c1-12-2-3-13(21(34,20(27)33)22(23,24)25)8-15(12)17-9-30-19(26)16(31-17)5-4-14-11-32-7-6-28-18(32)10-29-14/h2-3,6-11,34H,1H3,(H2,26,30)(H2,27,33)	YRHFFZSGYDMXFD-UHFFFAOYSA-N	506914	US11046658, Example 68++::US20250388553, Example 68	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506914&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305457	459092052							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123811	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccnn1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H17F3N6O2/c1-9-3-4-10(17(29,16(23)28)18(19,20)21)7-11(9)12-8-24-15(22)14(26-12)13-5-6-25-27(13)2/h3-8,29H,1-2H3,(H2,22,24)(H2,23,28)	ZPSFLAJYOZXKOV-UHFFFAOYSA-N	506915	US11046658, Example 69::US20250388553, Example 69	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506915&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149547652	459092053							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123812	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccnn1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H17F3N6O2/c1-9-3-4-10(17(29,16(23)28)18(19,20)21)7-11(9)12-8-24-15(22)14(26-12)13-5-6-25-27(13)2/h3-8,29H,1-2H3,(H2,22,24)(H2,23,28)	ZPSFLAJYOZXKOV-UHFFFAOYSA-N	506915	US11046658, Example 69::US20250388553, Example 69	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506915&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149547652	459092053							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123813	Cc1ncc(o1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H16F3N5O3/c1-8-3-4-10(17(28,16(23)27)18(19,20)21)5-11(8)12-6-25-15(22)14(26-12)13-7-24-9(2)29-13/h3-7,28H,1-2H3,(H2,22,25)(H2,23,27)	TZXVHBJRKKAGRO-UHFFFAOYSA-N	506916	2-(3-(5-amino-6-(2- methyloxazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 70::US20250388553, Example 70	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506916&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151967269	459092054							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123814	Cc1ncc(o1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H16F3N5O3/c1-8-3-4-10(17(28,16(23)27)18(19,20)21)5-11(8)12-6-25-15(22)14(26-12)13-7-24-9(2)29-13/h3-7,28H,1-2H3,(H2,22,25)(H2,23,27)	TZXVHBJRKKAGRO-UHFFFAOYSA-N	506916	2-(3-(5-amino-6-(2- methyloxazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 70::US20250388553, Example 70	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506916&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151967269	459092054							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123815	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H17F3N6O2/c1-9-3-4-11(17(29,16(23)28)18(19,20)21)5-12(9)13-7-24-15(22)14(26-13)10-6-25-27(2)8-10/h3-8,29H,1-2H3,(H2,22,24)(H2,23,28)	ZGBFYIPSTQMPQY-UHFFFAOYSA-N	506917	2-(3-(5-amino-6-(1- methyl-1H-pyrazol-4- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 71::US20250388553, Example 71	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506917&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152643482	459092055							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123816	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H17F3N6O2/c1-9-3-4-11(17(29,16(23)28)18(19,20)21)5-12(9)13-7-24-15(22)14(26-13)10-6-25-27(2)8-10/h3-8,29H,1-2H3,(H2,22,24)(H2,23,28)	ZGBFYIPSTQMPQY-UHFFFAOYSA-N	506917	2-(3-(5-amino-6-(1- methyl-1H-pyrazol-4- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 71::US20250388553, Example 71	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506917&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152643482	459092055							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123817	Cc1ncc(s1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H16F3N5O2S/c1-8-3-4-10(17(28,16(23)27)18(19,20)21)5-11(8)12-6-25-15(22)14(26-12)13-7-24-9(2)29-13/h3-7,28H,1-2H3,(H2,22,25)(H2,23,27)	PHEAANICMACWDL-UHFFFAOYSA-N	506918	2-(3-(5-amino-6-(2- methylthiazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 72::US20250388553, Example 72	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506918&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151454511	459092056							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123818	Cc1ncc(s1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H16F3N5O2S/c1-8-3-4-10(17(28,16(23)27)18(19,20)21)5-11(8)12-6-25-15(22)14(26-12)13-7-24-9(2)29-13/h3-7,28H,1-2H3,(H2,22,25)(H2,23,27)	PHEAANICMACWDL-UHFFFAOYSA-N	506918	2-(3-(5-amino-6-(2- methylthiazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 72::US20250388553, Example 72	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506918&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151454511	459092056							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123819	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)n1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H16F3N7O2/c1-8-3-4-9(16(29,15(22)28)17(18,19)20)5-10(8)11-6-23-14(21)13(25-11)12-7-24-27(2)26-12/h3-7,29H,1-2H3,(H2,21,23)(H2,22,28)	VMEVPGWOYVPFHU-UHFFFAOYSA-N	506919	2-(3-(5-amino-6-(2- methyl-2H-1,2,3-triazol-4- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 73::US20250388553, Example 73	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506919&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152156024	459092057							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123820	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)n1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H16F3N7O2/c1-8-3-4-9(16(29,15(22)28)17(18,19)20)5-10(8)11-6-23-14(21)13(25-11)12-7-24-27(2)26-12/h3-7,29H,1-2H3,(H2,21,23)(H2,22,28)	VMEVPGWOYVPFHU-UHFFFAOYSA-N	506919	2-(3-(5-amino-6-(2- methyl-2H-1,2,3-triazol-4- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 73::US20250388553, Example 73	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506919&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152156024	459092057							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123821	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnnn1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H16F3N7O2/c1-8-3-4-9(16(29,15(22)28)17(18,19)20)5-10(8)11-6-23-14(21)13(25-11)12-7-24-26-27(12)2/h3-7,29H,1-2H3,(H2,21,23)(H2,22,28)	RWYPPOILPVVWGQ-UHFFFAOYSA-N	506920	2-(3-(5-amino-6-(1- methyl-1H-1,2,3-triazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 74::US20250388553, Example 74	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506920&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151792755	459092058							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123822	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnnn1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H16F3N7O2/c1-8-3-4-9(16(29,15(22)28)17(18,19)20)5-10(8)11-6-23-14(21)13(25-11)12-7-24-26-27(12)2/h3-7,29H,1-2H3,(H2,21,23)(H2,22,28)	RWYPPOILPVVWGQ-UHFFFAOYSA-N	506920	2-(3-(5-amino-6-(1- methyl-1H-1,2,3-triazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 74::US20250388553, Example 74	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506920&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151792755	459092058							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123823	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(CC(F)(F)F)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H16F6N6O2/c1-9-2-3-11(18(33,16(27)32)19(23,24)25)4-12(9)13-6-28-15(26)14(30-13)10-5-29-31(7-10)8-17(20,21)22/h2-7,33H,8H2,1H3,(H2,26,28)(H2,27,32)	DRGCKTHIZKYCHE-UHFFFAOYSA-N	506921	2-(3-(5-amino-6-(1-(2,2,2- trifluoroethyl)-1H-pyrazol- 4-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 75::US20250388553, Example 75	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506921&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150080925	459092059							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123824	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(CC(F)(F)F)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H16F6N6O2/c1-9-2-3-11(18(33,16(27)32)19(23,24)25)4-12(9)13-6-28-15(26)14(30-13)10-5-29-31(7-10)8-17(20,21)22/h2-7,33H,8H2,1H3,(H2,26,28)(H2,27,32)	DRGCKTHIZKYCHE-UHFFFAOYSA-N	506921	2-(3-(5-amino-6-(1-(2,2,2- trifluoroethyl)-1H-pyrazol- 4-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 75::US20250388553, Example 75	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506921&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150080925	459092059							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123825	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(c1)C(C)(C)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H20F3N7O2/c1-11-4-5-13(20(33,18(27)32)21(22,23)24)6-14(11)15-8-28-17(26)16(30-15)12-7-29-31(9-12)19(2,3)10-25/h4-9,33H,1-3H3,(H2,26,28)(H2,27,32)	WHCDEJXBJNMIBB-UHFFFAOYSA-N	506922	2-(3-(5-amino-6-(1-(2- cyanopropan-2-yl)-1H- pyrazol-4-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 76::US20250388553, Example 76	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506922&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152259834	459092060							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123826	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(c1)C(C)(C)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H20F3N7O2/c1-11-4-5-13(20(33,18(27)32)21(22,23)24)6-14(11)15-8-28-17(26)16(30-15)12-7-29-31(9-12)19(2,3)10-25/h4-9,33H,1-3H3,(H2,26,28)(H2,27,32)	WHCDEJXBJNMIBB-UHFFFAOYSA-N	506922	2-(3-(5-amino-6-(1-(2- cyanopropan-2-yl)-1H- pyrazol-4-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 76::US20250388553, Example 76	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506922&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152259834	459092060							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123827	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(c1)C1CCOCC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H23F3N6O3/c1-12-2-3-14(21(33,20(27)32)22(23,24)25)8-16(12)17-10-28-19(26)18(30-17)13-9-29-31(11-13)15-4-6-34-7-5-15/h2-3,8-11,15,33H,4-7H2,1H3,(H2,26,28)(H2,27,32)	XFIDPKYZISMCJG-UHFFFAOYSA-N	506923	2-(3-(5-amino-6-(1- (tetrahydro-2H-pyran-4- yl)-1H-pyrazol-4- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 77::US20250388553, Example 77	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506923&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152380651	459092061							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123828	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(c1)C1CCOCC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H23F3N6O3/c1-12-2-3-14(21(33,20(27)32)22(23,24)25)8-16(12)17-10-28-19(26)18(30-17)13-9-29-31(11-13)15-4-6-34-7-5-15/h2-3,8-11,15,33H,4-7H2,1H3,(H2,26,28)(H2,27,32)	XFIDPKYZISMCJG-UHFFFAOYSA-N	506923	2-(3-(5-amino-6-(1- (tetrahydro-2H-pyran-4- yl)-1H-pyrazol-4- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 77::US20250388553, Example 77	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506923&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152380651	459092061							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123829	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(CC2(CC2)C#N)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H20F3N7O2/c1-12-2-3-14(21(34,19(28)33)22(23,24)25)6-15(12)16-8-29-18(27)17(31-16)13-7-30-32(9-13)11-20(10-26)4-5-20/h2-3,6-9,34H,4-5,11H2,1H3,(H2,27,29)(H2,28,33)	LZJPELDTDNLKQH-UHFFFAOYSA-N	506924	2-(3-(5-amino-6-(1-((1- cyanocyclopropyl)methyl)- 1H-pyrazol-4-yl)pyrazin- 2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 78::US20250388553, Example 78	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506924&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151027623	459092062							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123830	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(CC2(CC2)C#N)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H20F3N7O2/c1-12-2-3-14(21(34,19(28)33)22(23,24)25)6-15(12)16-8-29-18(27)17(31-16)13-7-30-32(9-13)11-20(10-26)4-5-20/h2-3,6-9,34H,4-5,11H2,1H3,(H2,27,29)(H2,28,33)	LZJPELDTDNLKQH-UHFFFAOYSA-N	506924	2-(3-(5-amino-6-(1-((1- cyanocyclopropyl)methyl)- 1H-pyrazol-4-yl)pyrazin- 2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 78::US20250388553, Example 78	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506924&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151027623	459092062							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123831	COCCn1cc(cn1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H21F3N6O3/c1-11-3-4-13(19(31,18(25)30)20(21,22)23)7-14(11)15-9-26-17(24)16(28-15)12-8-27-29(10-12)5-6-32-2/h3-4,7-10,31H,5-6H2,1-2H3,(H2,24,26)(H2,25,30)	CKPXBKXRFHIZCT-UHFFFAOYSA-N	506925	2-(3-(5-amino-6-(1-(2- methoxyethyl)-1H- pyrazol-4-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 79::US20250388553, Example 79	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506925&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149918044	459092063							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123832	COCCn1cc(cn1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H21F3N6O3/c1-11-3-4-13(19(31,18(25)30)20(21,22)23)7-14(11)15-9-26-17(24)16(28-15)12-8-27-29(10-12)5-6-32-2/h3-4,7-10,31H,5-6H2,1-2H3,(H2,24,26)(H2,25,30)	CKPXBKXRFHIZCT-UHFFFAOYSA-N	506925	2-(3-(5-amino-6-(1-(2- methoxyethyl)-1H- pyrazol-4-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 79::US20250388553, Example 79	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506925&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149918044	459092063							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123833	CNC(=O)c1ccc(cn1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H19F3N6O3/c1-10-3-5-12(20(33,19(26)32)21(22,23)24)7-13(10)15-9-29-17(25)16(30-15)11-4-6-14(28-8-11)18(31)27-2/h3-9,33H,1-2H3,(H2,25,29)(H2,26,32)(H,27,31)	YVTNWQDZQIZZKI-UHFFFAOYSA-N	506926	5-(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)pyrazin-2- yl)-N-methylpicolinamide bistrifluoroacetate::US11046658, Example 80::US20250388553, Example 80	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506926&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152592478	459092064							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123834	CNC(=O)c1ccc(cn1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H19F3N6O3/c1-10-3-5-12(20(33,19(26)32)21(22,23)24)7-13(10)15-9-29-17(25)16(30-15)11-4-6-14(28-8-11)18(31)27-2/h3-9,33H,1-2H3,(H2,25,29)(H2,26,32)(H,27,31)	YVTNWQDZQIZZKI-UHFFFAOYSA-N	506926	5-(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)pyrazin-2- yl)-N-methylpicolinamide bistrifluoroacetate::US11046658, Example 80::US20250388553, Example 80	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506926&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152592478	459092064							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123835	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cncnc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H15F3N6O2/c1-9-2-3-11(17(29,16(23)28)18(19,20)21)4-12(9)13-7-26-15(22)14(27-13)10-5-24-8-25-6-10/h2-8,29H,1H3,(H2,22,26)(H2,23,28)	RHBDFNWLVBCQEC-UHFFFAOYSA-N	506927	2-(3-(5-amino-6- (pyrimidin-5-yl)pyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 81::US20250388553, Example 81	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506927&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151713556	459092065							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123836	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cncnc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C18H15F3N6O2/c1-9-2-3-11(17(29,16(23)28)18(19,20)21)4-12(9)13-7-26-15(22)14(27-13)10-5-24-8-25-6-10/h2-8,29H,1H3,(H2,22,26)(H2,23,28)	RHBDFNWLVBCQEC-UHFFFAOYSA-N	506927	2-(3-(5-amino-6- (pyrimidin-5-yl)pyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 81::US20250388553, Example 81	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506927&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151713556	459092065							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123837	Cc1ccc(cn1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H18F3N5O2/c1-10-3-6-13(19(30,18(25)29)20(21,22)23)7-14(10)15-9-27-17(24)16(28-15)12-5-4-11(2)26-8-12/h3-9,30H,1-2H3,(H2,24,27)(H2,25,29)	KGAZFNCJVLSBBH-UHFFFAOYSA-N	506928	2-(3-(5-amino-6-(6- methylpyridin-3- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide bistrifluoroacetate::US11046658, Example 82::US20250388553, Example 82	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506928&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150801951	459092066							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123838	Cc1ccc(cn1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H18F3N5O2/c1-10-3-6-13(19(30,18(25)29)20(21,22)23)7-14(10)15-9-27-17(24)16(28-15)12-5-4-11(2)26-8-12/h3-9,30H,1-2H3,(H2,24,27)(H2,25,29)	KGAZFNCJVLSBBH-UHFFFAOYSA-N	506928	2-(3-(5-amino-6-(6- methylpyridin-3- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide bistrifluoroacetate::US11046658, Example 82::US20250388553, Example 82	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506928&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150801951	459092066							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123839	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(nc1)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H15F6N5O2/c1-9-2-4-11(18(33,17(28)32)20(24,25)26)6-12(9)13-8-30-16(27)15(31-13)10-3-5-14(29-7-10)19(21,22)23/h2-8,33H,1H3,(H2,27,30)(H2,28,32)	PDKKIJQYLGXTLL-UHFFFAOYSA-N	506929	2-(3-(5-amino-6-(6- (trifluoromethyl)pyridin-3- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide bistrifluoroacetate::US11046658, Example 83::US20250388553, Example 83	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506929&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151435528	459092067							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123840	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(nc1)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H15F6N5O2/c1-9-2-4-11(18(33,17(28)32)20(24,25)26)6-12(9)13-8-30-16(27)15(31-13)10-3-5-14(29-7-10)19(21,22)23/h2-8,33H,1H3,(H2,27,30)(H2,28,32)	PDKKIJQYLGXTLL-UHFFFAOYSA-N	506929	2-(3-(5-amino-6-(6- (trifluoromethyl)pyridin-3- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide bistrifluoroacetate::US11046658, Example 83::US20250388553, Example 83	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506929&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151435528	459092067							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123841	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnc(s1)C1CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H18F3N5O2S/c1-9-2-5-11(19(30,18(25)29)20(21,22)23)6-12(9)13-7-26-16(24)15(28-13)14-8-27-17(31-14)10-3-4-10/h2,5-8,10,30H,3-4H2,1H3,(H2,24,26)(H2,25,29)	KBTGUDCETAFYDD-UHFFFAOYSA-N	506930	2-(3-(5-amino-6-(2- cyclopropylthiazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 84::US20250388553, Example 84	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506930&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150780442	459092068							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123842	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnc(s1)C1CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H18F3N5O2S/c1-9-2-5-11(19(30,18(25)29)20(21,22)23)6-12(9)13-7-26-16(24)15(28-13)14-8-27-17(31-14)10-3-4-10/h2,5-8,10,30H,3-4H2,1H3,(H2,24,26)(H2,25,29)	KBTGUDCETAFYDD-UHFFFAOYSA-N	506930	2-(3-(5-amino-6-(2- cyclopropylthiazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 84::US20250388553, Example 84	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506930&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150780442	459092068							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123843	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccnc(CO)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H18F3N5O3/c1-10-2-3-12(19(31,18(25)30)20(21,22)23)7-14(10)15-8-27-17(24)16(28-15)11-4-5-26-13(6-11)9-29/h2-8,29,31H,9H2,1H3,(H2,24,27)(H2,25,30)	DFBAYEAQKINJEG-UHFFFAOYSA-N	506931	2-(3-(5-amino-6-(2- (hydroxymethyl)pyridin-4- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide bistrifluoroacetate::US11046658, Example 85::US20250388553, Example 85	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506931&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150019963	459092069							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123844	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccnc(CO)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H18F3N5O3/c1-10-2-3-12(19(31,18(25)30)20(21,22)23)7-14(10)15-8-27-17(24)16(28-15)11-4-5-26-13(6-11)9-29/h2-8,29,31H,9H2,1H3,(H2,24,27)(H2,25,30)	DFBAYEAQKINJEG-UHFFFAOYSA-N	506931	2-(3-(5-amino-6-(2- (hydroxymethyl)pyridin-4- yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide bistrifluoroacetate::US11046658, Example 85::US20250388553, Example 85	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506931&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150019963	459092069							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123845	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(CC2CC2)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H21F3N6O2/c1-11-2-5-14(20(32,19(26)31)21(22,23)24)6-15(11)16-8-27-18(25)17(29-16)13-7-28-30(10-13)9-12-3-4-12/h2,5-8,10,12,32H,3-4,9H2,1H3,(H2,25,27)(H2,26,31)	FKGBGHFEPBXKGA-UHFFFAOYSA-N	506932	2-(3-(5-amino-6-(1- (cyclopropylmethyl)-1H- pyrazol-4-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 86::US20250388553, Example 86	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506932&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150175088	459092070							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123846	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(CC2CC2)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H21F3N6O2/c1-11-2-5-14(20(32,19(26)31)21(22,23)24)6-15(11)16-8-27-18(25)17(29-16)13-7-28-30(10-13)9-12-3-4-12/h2,5-8,10,12,32H,3-4,9H2,1H3,(H2,25,27)(H2,26,31)	FKGBGHFEPBXKGA-UHFFFAOYSA-N	506932	2-(3-(5-amino-6-(1- (cyclopropylmethyl)-1H- pyrazol-4-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 86::US20250388553, Example 86	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506932&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150175088	459092070							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123847	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(CC#N)cc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H18F3N5O2/c1-12-2-7-15(21(32,20(28)31)22(23,24)25)10-16(12)17-11-29-19(27)18(30-17)14-5-3-13(4-6-14)8-9-26/h2-7,10-11,32H,8H2,1H3,(H2,27,29)(H2,28,31)	NIDKHJQDPZSAOJ-UHFFFAOYSA-N	506933	2-(3-(5-amino-6-(4- (cyanomethyl)phenyl) pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 87::US20250388553, Example 87	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506933&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151200152	459092071					C04116		1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123848	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(CC#N)cc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H18F3N5O2/c1-12-2-7-15(21(32,20(28)31)22(23,24)25)10-16(12)17-11-29-19(27)18(30-17)14-5-3-13(4-6-14)8-9-26/h2-7,10-11,32H,8H2,1H3,(H2,27,29)(H2,28,31)	NIDKHJQDPZSAOJ-UHFFFAOYSA-N	506933	2-(3-(5-amino-6-(4- (cyanomethyl)phenyl) pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 87::US20250388553, Example 87	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506933&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151200152	459092071					C04116		1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123849	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(CO)cc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H19F3N4O3/c1-11-2-7-14(20(31,19(26)30)21(22,23)24)8-15(11)16-9-27-18(25)17(28-16)13-5-3-12(10-29)4-6-13/h2-9,29,31H,10H2,1H3,(H2,25,27)(H2,26,30)	XRTVJQUMVVRDIV-UHFFFAOYSA-N	506934	2-(3-(5-amino-6-(4- (hydroxymethyl)phenyl) pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 88::US20250388553, Example 88	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506934&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152442579	459092072							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123850	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(CO)cc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H19F3N4O3/c1-11-2-7-14(20(31,19(26)30)21(22,23)24)8-15(11)16-9-27-18(25)17(28-16)13-5-3-12(10-29)4-6-13/h2-9,29,31H,10H2,1H3,(H2,25,27)(H2,26,30)	XRTVJQUMVVRDIV-UHFFFAOYSA-N	506934	2-(3-(5-amino-6-(4- (hydroxymethyl)phenyl) pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 88::US20250388553, Example 88	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506934&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152442579	459092072							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123851	CNC(=O)c1ccc(cc1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H20F3N5O3/c1-11-3-8-14(21(33,20(27)32)22(23,24)25)9-15(11)16-10-29-18(26)17(30-16)12-4-6-13(7-5-12)19(31)28-2/h3-10,33H,1-2H3,(H2,26,29)(H2,27,32)(H,28,31)	NDUFKHMPZGMTBH-UHFFFAOYSA-N	506935	4-(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)pyrazin-2- yl)-N-methylbenzamide trifluoroacetate::US11046658, Example 89::US20250388553, Example 89	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506935&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151178529	459092073							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123852	CNC(=O)c1ccc(cc1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H20F3N5O3/c1-11-3-8-14(21(33,20(27)32)22(23,24)25)9-15(11)16-10-29-18(26)17(30-16)12-4-6-13(7-5-12)19(31)28-2/h3-10,33H,1-2H3,(H2,26,29)(H2,27,32)(H,28,31)	NDUFKHMPZGMTBH-UHFFFAOYSA-N	506935	4-(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- 3-oxopropan-2-yl)-2- methylphenyl)pyrazin-2- yl)-N-methylbenzamide trifluoroacetate::US11046658, Example 89::US20250388553, Example 89	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506935&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151178529	459092073							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123853	CC(C)c1cccc(c1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H23F3N4O2/c1-12(2)14-5-4-6-15(9-14)19-20(27)29-11-18(30-19)17-10-16(8-7-13(17)3)22(32,21(28)31)23(24,25)26/h4-12,32H,1-3H3,(H2,27,29)(H2,28,31)	KOYXRJCUFCARGG-UHFFFAOYSA-N	506936	2-(3-(5-amino-6-(3- isopropylphenyl)pyrazin- 2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 90::US20250388553, Example 90	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506936&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150845811	459092074							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123854	CC(C)c1cccc(c1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H23F3N4O2/c1-12(2)14-5-4-6-15(9-14)19-20(27)29-11-18(30-19)17-10-16(8-7-13(17)3)22(32,21(28)31)23(24,25)26/h4-12,32H,1-3H3,(H2,27,29)(H2,28,31)	KOYXRJCUFCARGG-UHFFFAOYSA-N	506936	2-(3-(5-amino-6-(3- isopropylphenyl)pyrazin- 2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 90::US20250388553, Example 90	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506936&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150845811	459092074							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123855	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(cc1)C(C)(C)O)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H23F3N4O3/c1-12-4-7-15(22(33,20(28)31)23(24,25)26)10-16(12)17-11-29-19(27)18(30-17)13-5-8-14(9-6-13)21(2,3)32/h4-11,32-33H,1-3H3,(H2,27,29)(H2,28,31)	XVIRRSWMVJRDDU-UHFFFAOYSA-N	506937	2-(3-(5-amino-6-(4-(2- hydroxypropan-2- yl)phenyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 91::US20250388553, Example 91	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506937&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152460522	459092075							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123856	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(cc1)C(C)(C)O)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H23F3N4O3/c1-12-4-7-15(22(33,20(28)31)23(24,25)26)10-16(12)17-11-29-19(27)18(30-17)13-5-8-14(9-6-13)21(2,3)32/h4-11,32-33H,1-3H3,(H2,27,29)(H2,28,31)	XVIRRSWMVJRDDU-UHFFFAOYSA-N	506937	2-(3-(5-amino-6-(4-(2- hydroxypropan-2- yl)phenyl)pyrazin-2-yl)-4- methylphenyl)-3,3,3- trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 91::US20250388553, Example 91	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506937&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152460522	459092075							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123857	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(cc1)C1CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H21F3N4O2/c1-12-2-9-16(22(32,21(28)31)23(24,25)26)10-17(12)18-11-29-20(27)19(30-18)15-7-5-14(6-8-15)13-3-4-13/h2,5-11,13,32H,3-4H2,1H3,(H2,27,29)(H2,28,31)	CEHIAKPZQPQYCS-UHFFFAOYSA-N	506938	2-(3-(5-amino-6-(4- cyclopropylphenyl) pyrazin-2-yl)-4- methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 92::US20250388553, Example 92	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506938&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149886579	459092076							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123858	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(cc1)C1CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H21F3N4O2/c1-12-2-9-16(22(32,21(28)31)23(24,25)26)10-17(12)18-11-29-20(27)19(30-18)15-7-5-14(6-8-15)13-3-4-13/h2,5-11,13,32H,3-4H2,1H3,(H2,27,29)(H2,28,31)	CEHIAKPZQPQYCS-UHFFFAOYSA-N	506938	2-(3-(5-amino-6-(4- cyclopropylphenyl) pyrazin-2-yl)-4- methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 92::US20250388553, Example 92	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506938&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149886579	459092076							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123859	Cc1ccc(cc1-c1cnc(N)c(n1)-n1cccn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H15F3N6O2/c1-9-3-4-10(16(28,15(22)27)17(18,19)20)7-11(9)12-8-23-13(21)14(25-12)26-6-2-5-24-26/h2-8,28H,1H3,(H2,21,23)(H2,22,27)	XPGFSSKUZXBCQO-UHFFFAOYSA-N	506939	US11046658, Example 93::US20250388553, Example 93	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506939&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152429931	459092077							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123860	Cc1ccc(cc1-c1cnc(N)c(n1)-n1cccn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C17H15F3N6O2/c1-9-3-4-10(16(28,15(22)27)17(18,19)20)7-11(9)12-8-23-13(21)14(25-12)26-6-2-5-24-26/h2-8,28H,1H3,(H2,21,23)(H2,22,27)	XPGFSSKUZXBCQO-UHFFFAOYSA-N	506939	US11046658, Example 93::US20250388553, Example 93	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506939	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506939&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152429931	459092077							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123861	CNC(=O)C(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-n1cncn1)C(F)(F)F	InChI=1S/C17H16F3N7O2/c1-9-3-4-10(16(29,15(28)22-2)17(18,19)20)5-11(9)12-6-24-13(21)14(26-12)27-8-23-7-25-27/h3-8,29H,1-2H3,(H2,21,24)(H,22,28)	RYQPPALDDSJVJN-UHFFFAOYSA-N	506940	US11046658, Example 94::US20250388553, Example 94	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506940&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151801222	459092078							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123862	CNC(=O)C(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-n1cncn1)C(F)(F)F	InChI=1S/C17H16F3N7O2/c1-9-3-4-10(16(29,15(28)22-2)17(18,19)20)5-11(9)12-6-24-13(21)14(26-12)27-8-23-7-25-27/h3-8,29H,1-2H3,(H2,21,24)(H,22,28)	RYQPPALDDSJVJN-UHFFFAOYSA-N	506940	US11046658, Example 94::US20250388553, Example 94	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506940&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151801222	459092078							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123863	CN(C)C(=O)C(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-n1cncn1)C(F)(F)F	InChI=1S/C18H18F3N7O2/c1-10-4-5-11(17(30,18(19,20)21)16(29)27(2)3)6-12(10)13-7-24-14(22)15(26-13)28-9-23-8-25-28/h4-9,30H,1-3H3,(H2,22,24)	VPDOLZAYSUEPGE-UHFFFAOYSA-N	506941	US11046658, Example 95::US20250388553, Example 95	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506941&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152170626	459092079							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123864	CN(C)C(=O)C(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-n1cncn1)C(F)(F)F	InChI=1S/C18H18F3N7O2/c1-10-4-5-11(17(30,18(19,20)21)16(29)27(2)3)6-12(10)13-7-24-14(22)15(26-13)28-9-23-8-25-28/h4-9,30H,1-3H3,(H2,22,24)	VPDOLZAYSUEPGE-UHFFFAOYSA-N	506941	US11046658, Example 95::US20250388553, Example 95	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506941&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152170626	459092079							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123865	CNC(=O)C(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-c1cnn(C)c1)C(F)(F)F	InChI=1S/C19H19F3N6O2/c1-10-4-5-12(18(30,17(29)24-2)19(20,21)22)6-13(10)14-8-25-16(23)15(27-14)11-7-26-28(3)9-11/h4-9,30H,1-3H3,(H2,23,25)(H,24,29)	OEFSGRUELWCNRD-UHFFFAOYSA-N	506942	US11046658, Example 96::US20250388553, Example 96	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506942&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151309974	459092080							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123866	CNC(=O)C(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-c1cnn(C)c1)C(F)(F)F	InChI=1S/C19H19F3N6O2/c1-10-4-5-12(18(30,17(29)24-2)19(20,21)22)6-13(10)14-8-25-16(23)15(27-14)11-7-26-28(3)9-11/h4-9,30H,1-3H3,(H2,23,25)(H,24,29)	OEFSGRUELWCNRD-UHFFFAOYSA-N	506942	US11046658, Example 96::US20250388553, Example 96	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506942&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151309974	459092080							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123867	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(cc1)B(O)O)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H18BF3N4O4/c1-10-2-5-12(19(30,18(26)29)20(22,23)24)8-14(10)15-9-27-17(25)16(28-15)11-3-6-13(7-4-11)21(31)32/h2-9,30-32H,1H3,(H2,25,27)(H2,26,29)	GQHCAZFHBVICIP-UHFFFAOYSA-N	506943	US11046658, Example 97::US20250388553, Example 97	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506943&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150334031	459092081							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123868	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(cc1)B(O)O)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H18BF3N4O4/c1-10-2-5-12(19(30,18(26)29)20(22,23)24)8-14(10)15-9-27-17(25)16(28-15)11-3-6-13(7-4-11)21(31)32/h2-9,30-32H,1H3,(H2,25,27)(H2,26,29)	GQHCAZFHBVICIP-UHFFFAOYSA-N	506943	US11046658, Example 97::US20250388553, Example 97	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506943&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150334031	459092081							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123869	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccnn1C)C(O)(C(F)F)C(N)=O	InChI=1S/C18H18F2N6O2/c1-9-3-4-10(18(28,16(19)20)17(22)27)7-11(9)12-8-23-15(21)14(25-12)13-5-6-24-26(13)2/h3-8,16,28H,1-2H3,(H2,21,23)(H2,22,27)	NANPNVKIAMKUAZ-UHFFFAOYSA-N	506944	US11046658, Example 99::US11046658, Example 98::US20250388553, Example 99	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506944&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			148590503	459092082							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123870	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccnn1C)C(O)(C(F)F)C(N)=O	InChI=1S/C18H18F2N6O2/c1-9-3-4-10(18(28,16(19)20)17(22)27)7-11(9)12-8-23-15(21)14(25-12)13-5-6-24-26(13)2/h3-8,16,28H,1-2H3,(H2,21,23)(H2,22,27)	NANPNVKIAMKUAZ-UHFFFAOYSA-N	506944	US11046658, Example 99::US11046658, Example 98::US20250388553, Example 99	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506944&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			148590503	459092082							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123871	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccnn1C)C(O)(C(F)F)C(N)=O	InChI=1S/C18H18F2N6O2/c1-9-3-4-10(18(28,16(19)20)17(22)27)7-11(9)12-8-23-15(21)14(25-12)13-5-6-24-26(13)2/h3-8,16,28H,1-2H3,(H2,21,23)(H2,22,27)	NANPNVKIAMKUAZ-UHFFFAOYSA-N	506944	US11046658, Example 99::US11046658, Example 98::US20250388553, Example 99	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506944&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			148590503	459092082							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123872	Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccnn1C)C(O)(C(F)F)C(N)=O	InChI=1S/C18H18F2N6O2/c1-9-3-4-10(18(28,16(19)20)17(22)27)7-11(9)12-8-23-15(21)14(25-12)13-5-6-24-26(13)2/h3-8,16,28H,1-2H3,(H2,21,23)(H2,22,27)	NANPNVKIAMKUAZ-UHFFFAOYSA-N	506944	US11046658, Example 99::US11046658, Example 98::US20250388553, Example 99	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506944&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			148590503	459092082							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123873	Cc1ncc(o1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(F)F)C(N)=O	InChI=1S/C18H17F2N5O3/c1-8-3-4-10(18(27,16(19)20)17(22)26)5-11(8)12-6-24-15(21)14(25-12)13-7-23-9(2)28-13/h3-7,16,27H,1-2H3,(H2,21,24)(H2,22,26)	LQBDRMBIAFWZTF-UHFFFAOYSA-N	506946	2-(3-(5-amino-6-(2- methyloxazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3- difluoro-2- hydroxypropanamide::US11046658, Example 100::US20250388553, Example 100	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506946&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150980817	459092083							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123874	Cc1ncc(o1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(F)F)C(N)=O	InChI=1S/C18H17F2N5O3/c1-8-3-4-10(18(27,16(19)20)17(22)26)5-11(8)12-6-24-15(21)14(25-12)13-7-23-9(2)28-13/h3-7,16,27H,1-2H3,(H2,21,24)(H2,22,26)	LQBDRMBIAFWZTF-UHFFFAOYSA-N	506946	2-(3-(5-amino-6-(2- methyloxazol-5- yl)pyrazin-2-yl)-4- methylphenyl)-3,3- difluoro-2- hydroxypropanamide::US11046658, Example 100::US20250388553, Example 100	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506946&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150980817	459092083							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123875	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)n1)C(O)(C(F)F)C(N)=O	InChI=1S/C17H17F2N7O2/c1-8-3-4-9(17(28,15(18)19)16(21)27)5-10(8)11-6-22-14(20)13(24-11)12-7-23-26(2)25-12/h3-7,15,28H,1-2H3,(H2,20,22)(H2,21,27)	UEINNYNIPAZRIC-UHFFFAOYSA-N	506947	2-(3-(5-amino-6-(2- methyl-2H-1,2,3- triazol-4-yl)pyrazin- 2-yl)-4- methylphenyl)-3,3- difluoro-2- hydroxypropanamide::US11046658, Example 101::US20250388553, Example 101	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506947&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305428	459092084							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123876	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)n1)C(O)(C(F)F)C(N)=O	InChI=1S/C17H17F2N7O2/c1-8-3-4-9(17(28,15(18)19)16(21)27)5-10(8)11-6-22-14(20)13(24-11)12-7-23-26(2)25-12/h3-7,15,28H,1-2H3,(H2,20,22)(H2,21,27)	UEINNYNIPAZRIC-UHFFFAOYSA-N	506947	2-(3-(5-amino-6-(2- methyl-2H-1,2,3- triazol-4-yl)pyrazin- 2-yl)-4- methylphenyl)-3,3- difluoro-2- hydroxypropanamide::US11046658, Example 101::US20250388553, Example 101	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506947&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			153305428	459092084							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123877	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnc(s1)C1CC1)C(O)(CNC=O)C(F)(F)F	InChI=1S/C21H20F3N5O2S/c1-11-2-5-13(20(31,9-26-10-30)21(22,23)24)6-14(11)15-7-27-18(25)17(29-15)16-8-28-19(32-16)12-3-4-12/h2,5-8,10,12,31H,3-4,9H2,1H3,(H2,25,27)(H,26,30)	PYMHQRXJTGYESX-UHFFFAOYSA-N	506948	US11046658, Example 102::US20250388553, Example 102	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506948&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151541054	459092085					C06049		1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123878	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnc(s1)C1CC1)C(O)(CNC=O)C(F)(F)F	InChI=1S/C21H20F3N5O2S/c1-11-2-5-13(20(31,9-26-10-30)21(22,23)24)6-14(11)15-7-27-18(25)17(29-15)16-8-28-19(32-16)12-3-4-12/h2,5-8,10,12,31H,3-4,9H2,1H3,(H2,25,27)(H,26,30)	PYMHQRXJTGYESX-UHFFFAOYSA-N	506948	US11046658, Example 102::US20250388553, Example 102	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506948&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151541054	459092085					C06049		1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123879	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cn[nH]c1)C(O)(CNC=O)C(F)(F)F	InChI=1S/C18H17F3N6O2/c1-10-2-3-12(17(29,8-23-9-28)18(19,20)21)4-13(10)14-7-24-16(22)15(27-14)11-5-25-26-6-11/h2-7,9,29H,8H2,1H3,(H2,22,24)(H,23,28)(H,25,26)	ARSOUMXMLZKDGJ-UHFFFAOYSA-N	506949	US11046658, Example 103::US20250388553, Example 103	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506949&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			162370610	459092086					C06049		1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123880	Cc1ccc(cc1-c1cnc(N)c(n1)-c1cn[nH]c1)C(O)(CNC=O)C(F)(F)F	InChI=1S/C18H17F3N6O2/c1-10-2-3-12(17(29,8-23-9-28)18(19,20)21)4-13(10)14-7-24-16(22)15(27-14)11-5-25-26-6-11/h2-7,9,29H,8H2,1H3,(H2,22,24)(H,23,28)(H,25,26)	ARSOUMXMLZKDGJ-UHFFFAOYSA-N	506949	US11046658, Example 103::US20250388553, Example 103	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506949&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			162370610	459092086					C06049		1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123881	CC(=O)NCC(O)(c3ccc(C)c(c2cnc(N)c(c1cnn(CC(F)(F)F)c1)n2)c3)C(F)(F)F	InChI=1S/C21H20F6N6O2/c1-11-3-4-14(19(35,21(25,26)27)9-30-12(2)34)5-15(11)16-7-29-18(28)17(32-16)13-6-31-33(8-13)10-20(22,23)24/h3-8,35H,9-10H2,1-2H3,(H2,28,29)(H,30,34)	ZMIWSTXZXHUBNZ-UHFFFAOYSA-N	79897	US20250388553, Example 104	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79897&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			2809938	252656541							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123882	CC(=O)NCC(O)(c3ccc(C)c(c2cnc(N)c(c1cnn(CC(F)(F)F)c1)n2)c3)C(F)(F)F	InChI=1S/C21H20F6N6O2/c1-11-3-4-14(19(35,21(25,26)27)9-30-12(2)34)5-15(11)16-7-29-18(28)17(32-16)13-6-31-33(8-13)10-20(22,23)24/h3-8,35H,9-10H2,1-2H3,(H2,28,29)(H,30,34)	ZMIWSTXZXHUBNZ-UHFFFAOYSA-N	79897	US20250388553, Example 104	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79897&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			2809938	252656541							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123883	CC(=O)NCC(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-c1cn[nH]c1)C(F)(F)F	InChI=1S/C19H19F3N6O2/c1-10-3-4-13(18(30,19(20,21)22)9-25-11(2)29)5-14(10)15-8-24-17(23)16(28-15)12-6-26-27-7-12/h3-8,30H,9H2,1-2H3,(H2,23,24)(H,25,29)(H,26,27)	ATSYBJCMCHMBHQ-UHFFFAOYSA-N	506951	US11046658, Example 105::US20250388553, Example 105	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506951&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			162370611	459092088							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123884	CC(=O)NCC(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-c1cn[nH]c1)C(F)(F)F	InChI=1S/C19H19F3N6O2/c1-10-3-4-13(18(30,19(20,21)22)9-25-11(2)29)5-14(10)15-8-24-17(23)16(28-15)12-6-26-27-7-12/h3-8,30H,9H2,1-2H3,(H2,23,24)(H,25,29)(H,26,27)	ATSYBJCMCHMBHQ-UHFFFAOYSA-N	506951	US11046658, Example 105::US20250388553, Example 105	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506951&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			162370611	459092088							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123885	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)Nc1ccnn1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H18F3N7O3/c1-9-3-4-10(18(32,17(24)31)19(20,21)22)7-11(9)12-8-25-15(23)14(27-12)16(30)28-13-5-6-26-29(13)2/h3-8,32H,1-2H3,(H2,23,25)(H2,24,31)(H,28,30)	AZKDTLKWWVPVEX-UHFFFAOYSA-N	506952	US11046658, Example 106++::US20250388553, Example 106	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506952&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149732112	459092089							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123886	Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)Nc1ccnn1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C19H18F3N7O3/c1-9-3-4-10(18(32,17(24)31)19(20,21)22)7-11(9)12-8-25-15(23)14(27-12)16(30)28-13-5-6-26-29(13)2/h3-8,32H,1-2H3,(H2,23,25)(H2,24,31)(H,28,30)	AZKDTLKWWVPVEX-UHFFFAOYSA-N	506952	US11046658, Example 106++::US20250388553, Example 106	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506952&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149732112	459092089							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123887	Cc1ccc(cc1-c1cnc(N)c(n1)C1CN(C1)S(=O)(=O)c1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H22F3N7O4S/c1-11-3-4-13(20(33,19(26)32)21(22,23)24)5-15(11)16-7-27-18(25)17(29-16)12-8-31(9-12)36(34,35)14-6-28-30(2)10-14/h3-7,10,12,33H,8-9H2,1-2H3,(H2,25,27)(H2,26,32)	CJJNMDNROQEIPU-UHFFFAOYSA-N	506953	US11046658, Example 107::US20250388553, Example 107	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506953&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			147233579	459092090							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123888	Cc1ccc(cc1-c1cnc(N)c(n1)C1CN(C1)S(=O)(=O)c1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H22F3N7O4S/c1-11-3-4-13(20(33,19(26)32)21(22,23)24)5-15(11)16-7-27-18(25)17(29-16)12-8-31(9-12)36(34,35)14-6-28-30(2)10-14/h3-7,10,12,33H,8-9H2,1-2H3,(H2,25,27)(H2,26,32)	CJJNMDNROQEIPU-UHFFFAOYSA-N	506953	US11046658, Example 107::US20250388553, Example 107	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<2000							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506953&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			147233579	459092090							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123889	CCOC(=O)C1CC(c2nc(-c3cc([C@](O)(C(N)=O)C(F)(F)F)ccc3C)cnc2N)C1	InChI=1S/C21H23F3N4O4/c1-3-32-18(29)12-6-11(7-12)16-17(25)27-9-15(28-16)14-8-13(5-4-10(14)2)20(31,19(26)30)21(22,23)24/h4-5,8-9,11-12,31H,3,6-7H2,1-2H3,(H2,25,27)(H2,26,30)	FPYHJDYLMXOHSD-UHFFFAOYSA-N	79901	Ethyl 3-(3-amino-6-(5-(3-amino-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl)-2-methylphenyl)pyrazin-2-yl)cyclobutane-1-carboxylate (two Diastereomers Isolated: Cis- and Trans- Cyclobutanes)::US20250388553, Example 108	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79901&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			1769368	252656545							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123890	CCOC(=O)C1CC(c2nc(-c3cc([C@](O)(C(N)=O)C(F)(F)F)ccc3C)cnc2N)C1	InChI=1S/C21H23F3N4O4/c1-3-32-18(29)12-6-11(7-12)16-17(25)27-9-15(28-16)14-8-13(5-4-10(14)2)20(31,19(26)30)21(22,23)24/h4-5,8-9,11-12,31H,3,6-7H2,1-2H3,(H2,25,27)(H2,26,30)	FPYHJDYLMXOHSD-UHFFFAOYSA-N	79901	Ethyl 3-(3-amino-6-(5-(3-amino-1,1,1-trifluoro-2-hydroxy-3-oxopropan-2-yl)-2-methylphenyl)pyrazin-2-yl)cyclobutane-1-carboxylate (two Diastereomers Isolated: Cis- and Trans- Cyclobutanes)::US20250388553, Example 108	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<2000							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79901&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			1769368	252656545							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123891	CCOC(=O)C1CC(c2nc(-c3cc([C@@](O)(C(N)=O)C(F)(F)F)ccc3C)cnc2N)C1	InChI=1S/C21H23F3N4O4/c1-3-32-18(29)12-6-11(7-12)16-17(25)27-9-15(28-16)14-8-13(5-4-10(14)2)20(31,19(26)30)21(22,23)24/h4-5,8-9,11-12,31H,3,6-7H2,1-2H3,(H2,25,27)(H2,26,30)	FPYHJDYLMXOHSD-UHFFFAOYSA-N	79902	US20250388553, Example 109	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79902&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			1588119	252656546							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123892	CCOC(=O)C1CC(c2nc(-c3cc([C@@](O)(C(N)=O)C(F)(F)F)ccc3C)cnc2N)C1	InChI=1S/C21H23F3N4O4/c1-3-32-18(29)12-6-11(7-12)16-17(25)27-9-15(28-16)14-8-13(5-4-10(14)2)20(31,19(26)30)21(22,23)24/h4-5,8-9,11-12,31H,3,6-7H2,1-2H3,(H2,25,27)(H2,26,30)	FPYHJDYLMXOHSD-UHFFFAOYSA-N	79902	US20250388553, Example 109	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79902&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			1588119	252656546							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123893	CC(C)NC(=O)C1CC(C1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |(6.37,-8.24,;5.04,-7.47,;3.71,-8.24,;5.04,-5.93,;3.71,-5.16,;2.37,-5.93,;3.71,-3.62,;4.8,-2.53,;3.71,-1.44,;2.62,-2.53,;3.71,.1,;2.37,.87,;2.37,2.41,;3.71,3.18,;5.04,2.41,;5.04,.87,;6.37,.1,;1.04,3.18,;-.29,2.41,;-1.63,3.18,;-1.63,4.72,;-.29,5.49,;1.04,4.72,;2.37,5.49,;-2.96,2.41,;-3.73,3.74,;-4.3,1.64,;-4.3,.1,;-5.63,2.41,;-2.19,1.08,;-1.42,-.26,;-3.53,.31,;-.86,1.85,)|	InChI=1S/C22H26F3N5O3/c1-10(2)29-19(31)13-6-12(7-13)17-18(26)28-9-16(30-17)15-8-14(5-4-11(15)3)21(33,20(27)32)22(23,24)25/h4-5,8-10,12-13,33H,6-7H2,1-3H3,(H2,26,28)(H2,27,32)(H,29,31)	JABYYZQQYJPCJU-UHFFFAOYSA-N	506956	US11046658, Example 111::US11046658, Example 110::US20250388553, Example 111	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506956&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			148017736	459092093							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123894	CC(C)NC(=O)C1CC(C1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |(6.37,-8.24,;5.04,-7.47,;3.71,-8.24,;5.04,-5.93,;3.71,-5.16,;2.37,-5.93,;3.71,-3.62,;4.8,-2.53,;3.71,-1.44,;2.62,-2.53,;3.71,.1,;2.37,.87,;2.37,2.41,;3.71,3.18,;5.04,2.41,;5.04,.87,;6.37,.1,;1.04,3.18,;-.29,2.41,;-1.63,3.18,;-1.63,4.72,;-.29,5.49,;1.04,4.72,;2.37,5.49,;-2.96,2.41,;-3.73,3.74,;-4.3,1.64,;-4.3,.1,;-5.63,2.41,;-2.19,1.08,;-1.42,-.26,;-3.53,.31,;-.86,1.85,)|	InChI=1S/C22H26F3N5O3/c1-10(2)29-19(31)13-6-12(7-13)17-18(26)28-9-16(30-17)15-8-14(5-4-11(15)3)21(33,20(27)32)22(23,24)25/h4-5,8-10,12-13,33H,6-7H2,1-3H3,(H2,26,28)(H2,27,32)(H,29,31)	JABYYZQQYJPCJU-UHFFFAOYSA-N	506956	US11046658, Example 111::US11046658, Example 110::US20250388553, Example 111	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506956&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			148017736	459092093							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123895	CC(C)NC(=O)C1CC(C1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |(6.37,-8.24,;5.04,-7.47,;3.71,-8.24,;5.04,-5.93,;3.71,-5.16,;2.37,-5.93,;3.71,-3.62,;4.8,-2.53,;3.71,-1.44,;2.62,-2.53,;3.71,.1,;2.37,.87,;2.37,2.41,;3.71,3.18,;5.04,2.41,;5.04,.87,;6.37,.1,;1.04,3.18,;-.29,2.41,;-1.63,3.18,;-1.63,4.72,;-.29,5.49,;1.04,4.72,;2.37,5.49,;-2.96,2.41,;-3.73,3.74,;-4.3,1.64,;-4.3,.1,;-5.63,2.41,;-2.19,1.08,;-1.42,-.26,;-3.53,.31,;-.86,1.85,)|	InChI=1S/C22H26F3N5O3/c1-10(2)29-19(31)13-6-12(7-13)17-18(26)28-9-16(30-17)15-8-14(5-4-11(15)3)21(33,20(27)32)22(23,24)25/h4-5,8-10,12-13,33H,6-7H2,1-3H3,(H2,26,28)(H2,27,32)(H,29,31)	JABYYZQQYJPCJU-UHFFFAOYSA-N	506956	US11046658, Example 111::US11046658, Example 110::US20250388553, Example 111	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506956&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			148017736	459092093							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123896	CC(C)NC(=O)C1CC(C1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F |(6.37,-8.24,;5.04,-7.47,;3.71,-8.24,;5.04,-5.93,;3.71,-5.16,;2.37,-5.93,;3.71,-3.62,;4.8,-2.53,;3.71,-1.44,;2.62,-2.53,;3.71,.1,;2.37,.87,;2.37,2.41,;3.71,3.18,;5.04,2.41,;5.04,.87,;6.37,.1,;1.04,3.18,;-.29,2.41,;-1.63,3.18,;-1.63,4.72,;-.29,5.49,;1.04,4.72,;2.37,5.49,;-2.96,2.41,;-3.73,3.74,;-4.3,1.64,;-4.3,.1,;-5.63,2.41,;-2.19,1.08,;-1.42,-.26,;-3.53,.31,;-.86,1.85,)|	InChI=1S/C22H26F3N5O3/c1-10(2)29-19(31)13-6-12(7-13)17-18(26)28-9-16(30-17)15-8-14(5-4-11(15)3)21(33,20(27)32)22(23,24)25/h4-5,8-10,12-13,33H,6-7H2,1-3H3,(H2,26,28)(H2,27,32)(H,29,31)	JABYYZQQYJPCJU-UHFFFAOYSA-N	506956	US11046658, Example 111::US11046658, Example 110::US20250388553, Example 111	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506956&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			148017736	459092093							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123897	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(C2CC2)C(=O)C1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H23F3N6O3/c1-11-2-3-12(20(33,19(26)32)21(22,23)24)8-14(11)15-9-27-17(25)18(28-15)29-6-7-30(13-4-5-13)16(31)10-29/h2-3,8-9,13,33H,4-7,10H2,1H3,(H2,25,27)(H2,26,32)	XMIZMHXBJVNTPJ-UHFFFAOYSA-N	506958	US11046658, Example 112::US20250388553, Example 112	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506958&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152415591	459092094							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123898	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(C2CC2)C(=O)C1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H23F3N6O3/c1-11-2-3-12(20(33,19(26)32)21(22,23)24)8-14(11)15-9-27-17(25)18(28-15)29-6-7-30(13-4-5-13)16(31)10-29/h2-3,8-9,13,33H,4-7,10H2,1H3,(H2,25,27)(H2,26,32)	XMIZMHXBJVNTPJ-UHFFFAOYSA-N	506958	US11046658, Example 112::US20250388553, Example 112	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506958	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506958&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152415591	459092094							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123899	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(C(=O)C1)C(C)(C)C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H27F3N6O3/c1-12-5-6-13(21(34,19(27)33)22(23,24)25)9-14(12)15-10-28-17(26)18(29-15)30-7-8-31(16(32)11-30)20(2,3)4/h5-6,9-10,34H,7-8,11H2,1-4H3,(H2,26,28)(H2,27,33)	VIAYZLFSQHKRQV-UHFFFAOYSA-N	506959	2-(3-(5-amino-6-(4-tert-butyl-3- oxopiperazin-1-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 113::US20250388553, Example 113	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506959&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152135189	459092095							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123900	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(C(=O)C1)C(C)(C)C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C22H27F3N6O3/c1-12-5-6-13(21(34,19(27)33)22(23,24)25)9-14(12)15-10-28-17(26)18(29-15)30-7-8-31(16(32)11-30)20(2,3)4/h5-6,9-10,34H,7-8,11H2,1-4H3,(H2,26,28)(H2,27,33)	VIAYZLFSQHKRQV-UHFFFAOYSA-N	506959	2-(3-(5-amino-6-(4-tert-butyl-3- oxopiperazin-1-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 113::US20250388553, Example 113	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506959&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152135189	459092095							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123901	CC(=O)N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H23F3N6O3/c1-11-3-4-13(19(32,18(25)31)20(21,22)23)9-14(11)15-10-26-16(24)17(27-15)29-7-5-28(6-8-29)12(2)30/h3-4,9-10,32H,5-8H2,1-2H3,(H2,24,26)(H2,25,31)	NSGXOYHILYNDLL-UHFFFAOYSA-N	506960	2-(3-(6-(4-acetylpiperazin-1-yl)-5- aminopyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 114::US20250388553, Example 114	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506960&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151250770	459092096							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123902	CC(=O)N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C20H23F3N6O3/c1-11-3-4-13(19(32,18(25)31)20(21,22)23)9-14(11)15-10-26-16(24)17(27-15)29-7-5-28(6-8-29)12(2)30/h3-4,9-10,32H,5-8H2,1-2H3,(H2,24,26)(H2,25,31)	NSGXOYHILYNDLL-UHFFFAOYSA-N	506960	2-(3-(6-(4-acetylpiperazin-1-yl)-5- aminopyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 114::US20250388553, Example 114	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506960&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151250770	459092096							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123903	Cc1ccc([C@@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(N2CCN(C(=O)C3CC3)CC2)n1	InChI=1S/C22H25F3N6O3/c1-12-2-5-14(21(34,20(27)33)22(23,24)25)10-15(12)16-11-28-17(26)18(29-16)30-6-8-31(9-7-30)19(32)13-3-4-13/h2,5,10-11,13,34H,3-4,6-9H2,1H3,(H2,26,28)(H2,27,33)	KTUGNJQDCJISGN-UHFFFAOYSA-N	79911	(R)-2-(3-(5-amino-6-(4- (cyclopropanecarbonyl)piperazin- 1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US20250388553, Example 115	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79911&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			936790	252656555							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123904	Cc1ccc([C@@](O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(N2CCN(C(=O)C3CC3)CC2)n1	InChI=1S/C22H25F3N6O3/c1-12-2-5-14(21(34,20(27)33)22(23,24)25)10-15(12)16-11-28-17(26)18(29-16)30-6-8-31(9-7-30)19(32)13-3-4-13/h2,5,10-11,13,34H,3-4,6-9H2,1H3,(H2,26,28)(H2,27,33)	KTUGNJQDCJISGN-UHFFFAOYSA-N	79911	(R)-2-(3-(5-amino-6-(4- (cyclopropanecarbonyl)piperazin- 1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US20250388553, Example 115	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79911&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			936790	252656555							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123905	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1ccccc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C24H25F3N6O2/c1-15-7-8-16(23(35,22(29)34)24(25,26)27)13-18(15)19-14-30-20(28)21(31-19)33-11-9-32(10-12-33)17-5-3-2-4-6-17/h2-8,13-14,35H,9-12H2,1H3,(H2,28,30)(H2,29,34)	WNIFNSVMOJQVJS-UHFFFAOYSA-N	506962	2-(3-(5-amino-6-(4- phenylpiperazin-1-yl)pyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2-hydroxypropanamide trifluoroacetate::US11046658, Example 116::US20250388553, Example 116	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506962&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152290969	459092098							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123906	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1ccccc1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C24H25F3N6O2/c1-15-7-8-16(23(35,22(29)34)24(25,26)27)13-18(15)19-14-30-20(28)21(31-19)33-11-9-32(10-12-33)17-5-3-2-4-6-17/h2-8,13-14,35H,9-12H2,1H3,(H2,28,30)(H2,29,34)	WNIFNSVMOJQVJS-UHFFFAOYSA-N	506962	2-(3-(5-amino-6-(4- phenylpiperazin-1-yl)pyrazin-2- yl)-4-methylphenyl)-3,3,3- trifluoro-2-hydroxypropanamide trifluoroacetate::US11046658, Example 116::US20250388553, Example 116	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506962&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152290969	459092098							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123907	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1ccccn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H24F3N7O2/c1-14-5-6-15(22(35,21(28)34)23(24,25)26)12-16(14)17-13-30-19(27)20(31-17)33-10-8-32(9-11-33)18-4-2-3-7-29-18/h2-7,12-13,35H,8-11H2,1H3,(H2,27,30)(H2,28,34)	KKWRERJQHCCRAD-UHFFFAOYSA-N	506963	2-(3-(5-amino-6-(4-(pyridin-2- yl)piperazin-1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 117::US20250388553, Example 117	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506963&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150825776	459092099							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123908	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1ccccn1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H24F3N7O2/c1-14-5-6-15(22(35,21(28)34)23(24,25)26)12-16(14)17-13-30-19(27)20(31-17)33-10-8-32(9-11-33)18-4-2-3-7-29-18/h2-7,12-13,35H,8-11H2,1H3,(H2,27,30)(H2,28,34)	KKWRERJQHCCRAD-UHFFFAOYSA-N	506963	2-(3-(5-amino-6-(4-(pyridin-2- yl)piperazin-1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 117::US20250388553, Example 117	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506963	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506963&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150825776	459092099							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123909	Cc1ccccc1N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C25H27F3N6O2/c1-15-7-8-17(24(36,23(30)35)25(26,27)28)13-18(15)19-14-31-21(29)22(32-19)34-11-9-33(10-12-34)20-6-4-3-5-16(20)2/h3-8,13-14,36H,9-12H2,1-2H3,(H2,29,31)(H2,30,35)	OQQJGZSZBVIHOU-UHFFFAOYSA-N	506964	2-(3-(5-amino-6-(4-o- tolylpiperazin-1-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 118::US20250388553, Example 118	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506964&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151372054	459092100							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123910	Cc1ccccc1N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C25H27F3N6O2/c1-15-7-8-17(24(36,23(30)35)25(26,27)28)13-18(15)19-14-31-21(29)22(32-19)34-11-9-33(10-12-34)20-6-4-3-5-16(20)2/h3-8,13-14,36H,9-12H2,1-2H3,(H2,29,31)(H2,30,35)	OQQJGZSZBVIHOU-UHFFFAOYSA-N	506964	2-(3-(5-amino-6-(4-o- tolylpiperazin-1-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 118::US20250388553, Example 118	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506964&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151372054	459092100							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123911	Cc1ccc(C)c(c1)N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C26H29F3N6O2/c1-15-4-5-17(3)21(12-15)34-8-10-35(11-9-34)23-22(30)32-14-20(33-23)19-13-18(7-6-16(19)2)25(37,24(31)36)26(27,28)29/h4-7,12-14,37H,8-11H2,1-3H3,(H2,30,32)(H2,31,36)	VNSBVMHAGOUHAF-UHFFFAOYSA-N	506965	2-(3-(5-amino-6-(4-(2,5- dimethylphenyl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 119::US20250388553, Example 119	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506965&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152163461	459092101							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123912	Cc1ccc(C)c(c1)N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C26H29F3N6O2/c1-15-4-5-17(3)21(12-15)34-8-10-35(11-9-34)23-22(30)32-14-20(33-23)19-13-18(7-6-16(19)2)25(37,24(31)36)26(27,28)29/h4-7,12-14,37H,8-11H2,1-3H3,(H2,30,32)(H2,31,36)	VNSBVMHAGOUHAF-UHFFFAOYSA-N	506965	2-(3-(5-amino-6-(4-(2,5- dimethylphenyl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 119::US20250388553, Example 119	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506965&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152163461	459092101							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123913	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1cncs1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H22F3N7O2S/c1-12-2-3-13(20(33,19(26)32)21(22,23)24)8-14(12)15-9-28-17(25)18(29-15)31-6-4-30(5-7-31)16-10-27-11-34-16/h2-3,8-11,33H,4-7H2,1H3,(H2,25,28)(H2,26,32)	ZDECCHIAMUCPTE-UHFFFAOYSA-N	506966	2-(3-(5-amino-6-(4-(thiazol-5- yl)piperazin-1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 120::US20250388553, Example 120	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506966&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152629237	459092102							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123914	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1cncs1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H22F3N7O2S/c1-12-2-3-13(20(33,19(26)32)21(22,23)24)8-14(12)15-9-28-17(25)18(29-15)31-6-4-30(5-7-31)16-10-27-11-34-16/h2-3,8-11,33H,4-7H2,1H3,(H2,25,28)(H2,26,32)	ZDECCHIAMUCPTE-UHFFFAOYSA-N	506966	2-(3-(5-amino-6-(4-(thiazol-5- yl)piperazin-1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 120::US20250388553, Example 120	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506966	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506966&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152629237	459092102							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123915	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1cccc(c1)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C25H24F6N6O2/c1-14-5-6-15(23(39,22(33)38)25(29,30)31)12-18(14)19-13-34-20(32)21(35-19)37-9-7-36(8-10-37)17-4-2-3-16(11-17)24(26,27)28/h2-6,11-13,39H,7-10H2,1H3,(H2,32,34)(H2,33,38)	PFPGFPBNFVXUJN-UHFFFAOYSA-N	506967	2-(3-(5-amino-6-(4-(3- (trifluoromethyl)phenyl)piperazin- 1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 121::US20250388553, Example 121	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506967&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151446455	459092103							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123916	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1cccc(c1)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C25H24F6N6O2/c1-14-5-6-15(23(39,22(33)38)25(29,30)31)12-18(14)19-13-34-20(32)21(35-19)37-9-7-36(8-10-37)17-4-2-3-16(11-17)24(26,27)28/h2-6,11-13,39H,7-10H2,1H3,(H2,32,34)(H2,33,38)	PFPGFPBNFVXUJN-UHFFFAOYSA-N	506967	2-(3-(5-amino-6-(4-(3- (trifluoromethyl)phenyl)piperazin- 1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 121::US20250388553, Example 121	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506967	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506967&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151446455	459092103							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123917	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(N2CCN(c3ccccc3C#N)CC2)n1	InChI=1S/C25H24F3N7O2/c1-15-6-7-17(24(37,23(31)36)25(26,27)28)12-18(15)19-14-32-21(30)22(33-19)35-10-8-34(9-11-35)20-5-3-2-4-16(20)13-29/h2-7,12,14,37H,8-11H2,1H3,(H2,30,32)(H2,31,36)	KZXMNGLLHVXGRB-UHFFFAOYSA-N	79919	2-(3-(5 -amino-6-(4-(2- cyanophcnyl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US20250388553, Example 122	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79919&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			91898288	252656563							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123918	Cc1ccc(C(O)(C(N)=O)C(F)(F)F)cc1-c1cnc(N)c(N2CCN(c3ccccc3C#N)CC2)n1	InChI=1S/C25H24F3N7O2/c1-15-6-7-17(24(37,23(31)36)25(26,27)28)12-18(15)19-14-32-21(30)22(33-19)35-10-8-34(9-11-35)20-5-3-2-4-16(20)13-29/h2-7,12,14,37H,8-11H2,1H3,(H2,30,32)(H2,31,36)	KZXMNGLLHVXGRB-UHFFFAOYSA-N	79919	2-(3-(5 -amino-6-(4-(2- cyanophcnyl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US20250388553, Example 122	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79919&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			91898288	252656563							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123919	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1ccc(cc1)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C25H24F3N7O2/c1-15-2-5-17(24(37,23(31)36)25(26,27)28)12-19(15)20-14-32-21(30)22(33-20)35-10-8-34(9-11-35)18-6-3-16(13-29)4-7-18/h2-7,12,14,37H,8-11H2,1H3,(H2,30,32)(H2,31,36)	DFLXNIVVVXHRTH-UHFFFAOYSA-N	506969	2-(3-(5-amino-6-(4-(4- cyanophenyl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 123::US20250388553, Example 123	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506969&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150022143	459092105							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123920	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1ccc(cc1)C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C25H24F3N7O2/c1-15-2-5-17(24(37,23(31)36)25(26,27)28)12-19(15)20-14-32-21(30)22(33-20)35-10-8-34(9-11-35)18-6-3-16(13-29)4-7-18/h2-7,12,14,37H,8-11H2,1H3,(H2,30,32)(H2,31,36)	DFLXNIVVVXHRTH-UHFFFAOYSA-N	506969	2-(3-(5-amino-6-(4-(4- cyanophenyl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 123::US20250388553, Example 123	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506969	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506969&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150022143	459092105							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123921	Cc1ccc(cc1-c1cnc(N)c(n1)N1C[C@H](CO)N(C(=O)C1)c1ccc(O)cc1)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C25H25F3N6O5/c1-13-2-3-14(24(39,23(30)38)25(26,27)28)8-18(13)19-9-31-21(29)22(32-19)33-10-16(12-35)34(20(37)11-33)15-4-6-17(36)7-5-15/h2-9,16,35-36,39H,10-12H2,1H3,(H2,29,31)(H2,30,38)	QEYJYRZNNNRBTA-UHFFFAOYSA-N	506970	2-(3-(5-amino-6-((R)-3- (hydroxymethyl)-4-(4- hydroxyphenyl)-5-oxopiperazin- 1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 124::US20250388553, Example 124	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506970&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			151573496	459092106							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123922	Cc1ccc(cc1-c1cnc(N)c(n1)N1C[C@H](CO)N(C(=O)C1)c1ccc(O)cc1)C(O)(C(N)=O)C(F)(F)F |r|	InChI=1S/C25H25F3N6O5/c1-13-2-3-14(24(39,23(30)38)25(26,27)28)8-18(13)19-9-31-21(29)22(32-19)33-10-16(12-35)34(20(37)11-33)15-4-6-17(36)7-5-15/h2-9,16,35-36,39H,10-12H2,1H3,(H2,29,31)(H2,30,38)	QEYJYRZNNNRBTA-UHFFFAOYSA-N	506970	2-(3-(5-amino-6-((R)-3- (hydroxymethyl)-4-(4- hydroxyphenyl)-5-oxopiperazin- 1-yl)pyrazin-2-yl)-4- methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 124::US20250388553, Example 124	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506970	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506970&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			151573496	459092106							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123923	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CCC#N)CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H24F3N7O2/c1-13-3-4-14(20(33,19(27)32)21(22,23)24)11-15(13)16-12-28-17(26)18(29-16)31-9-7-30(8-10-31)6-2-5-25/h3-4,11-12,33H,2,6-10H2,1H3,(H2,26,28)(H2,27,32)	JMBPLQQPZJLSTR-UHFFFAOYSA-N	506971	2-(3-(5-amino-6-(4-(2- cyanoethyl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 125::US20250388553, Example 125	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506971&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150701968	459092107							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123924	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CCC#N)CC1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H24F3N7O2/c1-13-3-4-14(20(33,19(27)32)21(22,23)24)11-15(13)16-12-28-17(26)18(29-16)31-9-7-30(8-10-31)6-2-5-25/h3-4,11-12,33H,2,6-10H2,1H3,(H2,26,28)(H2,27,32)	JMBPLQQPZJLSTR-UHFFFAOYSA-N	506971	2-(3-(5-amino-6-(4-(2- cyanoethyl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 125::US20250388553, Example 125	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506971	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506971&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150701968	459092107							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123925	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN2C(CCC2=O)C1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H23F3N6O3/c1-11-2-3-12(20(33,19(26)32)21(22,23)24)8-14(11)15-9-27-17(25)18(28-15)29-6-7-30-13(10-29)4-5-16(30)31/h2-3,8-9,13,33H,4-7,10H2,1H3,(H2,25,27)(H2,26,32)	JFSJGUFSTAKAGV-UHFFFAOYSA-N	506972	2-(3-(5-amino-6-(6- oxohexahydropyrrolo[1,2- a]pyrazin-2(1H)-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 126::US20250388553, Example 126	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506972&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150670207	459092108							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123926	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN2C(CCC2=O)C1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C21H23F3N6O3/c1-11-2-3-12(20(33,19(26)32)21(22,23)24)8-14(11)15-9-27-17(25)18(28-15)29-6-7-30-13(10-29)4-5-16(30)31/h2-3,8-9,13,33H,4-7,10H2,1H3,(H2,25,27)(H2,26,32)	JFSJGUFSTAKAGV-UHFFFAOYSA-N	506972	2-(3-(5-amino-6-(6- oxohexahydropyrrolo[1,2- a]pyrazin-2(1H)-yl)pyrazin-2-yl)- 4-methylphenyl)-3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 126::US20250388553, Example 126	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506972	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506972&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150670207	459092108							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123927	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)C(=O)c1ccco1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H23F3N6O4/c1-13-4-5-14(22(35,21(28)34)23(24,25)26)11-15(13)16-12-29-18(27)19(30-16)31-6-8-32(9-7-31)20(33)17-3-2-10-36-17/h2-5,10-12,35H,6-9H2,1H3,(H2,27,29)(H2,28,34)	FHAIBQYIMIMDNE-UHFFFAOYSA-N	506973	2-(3-(5-amino-6-(4-(furan-2- carbonyl)piperazin-1-yl)pyrazin- 2-yl)-4-methylphenyl)-3,3,3- trifluoro-2-hydroxypropanamide trifluoroacetate::US11046658, Example 127::US20250388553, Example 127	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506973&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			150159870	459092109							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123928	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)C(=O)c1ccco1)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H23F3N6O4/c1-13-4-5-14(22(35,21(28)34)23(24,25)26)11-15(13)16-12-29-18(27)19(30-16)31-6-8-32(9-7-31)20(33)17-3-2-10-36-17/h2-5,10-12,35H,6-9H2,1H3,(H2,27,29)(H2,28,34)	FHAIBQYIMIMDNE-UHFFFAOYSA-N	506973	2-(3-(5-amino-6-(4-(furan-2- carbonyl)piperazin-1-yl)pyrazin- 2-yl)-4-methylphenyl)-3,3,3- trifluoro-2-hydroxypropanamide trifluoroacetate::US11046658, Example 127::US20250388553, Example 127	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506973	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506973&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			150159870	459092109							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123929	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1nccnc1C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H22F3N9O2/c1-13-2-3-14(22(37,21(29)36)23(24,25)26)10-15(13)17-12-32-18(28)20(33-17)35-8-6-34(7-9-35)19-16(11-27)30-4-5-31-19/h2-5,10,12,37H,6-9H2,1H3,(H2,28,32)(H2,29,36)	XWXWLDFPNOPDHI-UHFFFAOYSA-N	506974	2-(3-(5-amino-6-(4-(3- cyanopyrazin-2-yl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 128::US20250388553, Example 128	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506974&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			152468522	459092110							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123930	Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1nccnc1C#N)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C23H22F3N9O2/c1-13-2-3-14(22(37,21(29)36)23(24,25)26)10-15(13)17-12-32-18(28)20(33-17)35-8-6-34(7-9-35)19-16(11-27)30-4-5-31-19/h2-5,10,12,37H,6-9H2,1H3,(H2,28,32)(H2,29,36)	XWXWLDFPNOPDHI-UHFFFAOYSA-N	506974	2-(3-(5-amino-6-(4-(3- cyanopyrazin-2-yl)piperazin-1- yl)pyrazin-2-yl)-4-methylphenyl)- 3,3,3-trifluoro-2- hydroxypropanamide trifluoroacetate::US11046658, Example 128::US20250388553, Example 128	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506974	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506974&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			152468522	459092110							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123931	CCOc1ccccc1N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C26H29F3N6O3/c1-3-38-21-7-5-4-6-20(21)34-10-12-35(13-11-34)23-22(30)32-15-19(33-23)18-14-17(9-8-16(18)2)25(37,24(31)36)26(27,28)29/h4-9,14-15,37H,3,10-13H2,1-2H3,(H2,30,32)(H2,31,36)	CJAPWSGOQRNGIU-UHFFFAOYSA-N	506975	US11046658, Example 129++::US20250388553, Example 129	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens		<100							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2113&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506975&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+gamma+isoform&column=ki&startPg=0&Increment=50&submit=Search			149910139	459092111							1	MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA	8DP0,7MEZ,5KAE,5EDS,4WWP,4WWO,4WWN,4DK5,5JHB,5JHA,4FLH,4FJZ,4FJY,4FHK,4FHJ,4F1S,4AOF,3S2A,3QK0,3QJZ,3QAR,3QAQ,3L13,3DBS,8SC8,7Z61,7KKE,7JX0,7JWZ,7JWE,6T3C,6T3B,6GQ7,6FH5,6C1S,5T23,4URK,4J6I,4HLE,4GB9,4G11,4FAD,4FA6,3ZW3,3ZVV,3TL5,3T8M,3R7R,3R7Q,3PS6,3PRZ,3PRE,3OAW,3L17,3L16,3L08,3CST,3CSF,3APF,3APD,3APC,9GG9,5G2N,4ANW,4ANU,6XRN,6XRM,6XRL,3NZU,3NZS,1E90,1E8X,1E8W,1E7V	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PK3CG_HUMAN	P48736	A4D0Q6 Q8IV23 Q9BZC8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123932	CCOc1ccccc1N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F	InChI=1S/C26H29F3N6O3/c1-3-38-21-7-5-4-6-20(21)34-10-12-35(13-11-34)23-22(30)32-15-19(33-23)18-14-17(9-8-16(18)2)25(37,24(31)36)26(27,28)29/h4-9,14-15,37H,3,10-13H2,1-2H3,(H2,30,32)(H2,31,36)	CJAPWSGOQRNGIU-UHFFFAOYSA-N	506975	US11046658, Example 129++::US20250388553, Example 129	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens		<500							US Patent		10.7270/Q20K2FCJ			US20250388553	Douty, B; Ai, Y; Burns, DM; Combs, AP; Falahatpisheh, N; Levy, D; Polam, P; Shao, L; Shepard, S; Shvartsbart, A; Yue, EW; Buesking, AW	12/25/2025	5/6/2026	Incyte	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=506975	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2109&target=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=506975&enzyme=Phosphatidylinositol+4%2C5-bisphosphate+3-kinase+catalytic+subunit+delta+isoform&column=ki&startPg=0&Increment=50&submit=Search			149910139	459092111							1	MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ	9L3R,9GDI,9GCF,7LQ1,6OCU,5DXU,6G6W,7LM2,8S3R,8BCY,7JIS,6PYU,6PYR,6OCO,5T8F,5VLR,5UBT,5M6U	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PK3CD_HUMAN	O00329	A6NCG0 G1FFP1 O15445 Q5SR49