BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 123933 CNC(=O)c1ccc(-c2ccccc2SC)cc1S(C)(=O)=O InChI=1S/C16H17NO3S2/c1-17-16(18)13-9-8-11(10-15(13)22(3,19)20)12-6-4-5-7-14(12)21-2/h4-10H,1-3H3,(H,17,18) XIMOZHFQTSCNIY-UHFFFAOYSA-N 79491 US20250388560, Compound 1 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79491 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79491&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 42972763 252656142 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123934 CSc1ccccc1-c1ccc(C(=O)N(C)CC2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H29NO3S2/c1-24(16-17-9-5-4-6-10-17)23(25)20-14-13-18(15-22(20)29(3,26)27)19-11-7-8-12-21(19)28-2/h7-8,11-15,17H,4-6,9-10,16H2,1-3H3 DTGCKULGDLJUHI-UHFFFAOYSA-N 79492 US20250388560, Compound 2 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79492 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79492&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 4817362 252656143 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123935 CSc1ccccc1-c1ccc(C(=O)N(C)Cc2ccc3c(c2)OCO3)c(S(C)(=O)=O)c1 InChI=1S/C24H23NO5S2/c1-25(14-16-8-11-20-21(12-16)30-15-29-20)24(26)19-10-9-17(13-23(19)32(3,27)28)18-6-4-5-7-22(18)31-2/h4-13H,14-15H2,1-3H3 GTQAWPFNMFJVNP-UHFFFAOYSA-N 79494 US20250388560, Compound 3 E3 ubiquitin-protein ligase TRIM21 55 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79494 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79494&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 42974285 252656145 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123936 CSc1ccccc1-c1ccc(C(=O)N(C)Cc2ccsc2)c(S(C)(=O)=O)c1 InChI=1S/C21H21NO3S3/c1-22(13-15-10-11-27-14-15)21(23)18-9-8-16(12-20(18)28(3,24)25)17-6-4-5-7-19(17)26-2/h4-12,14H,13H2,1-3H3 FRFSTBRNJAYWNT-UHFFFAOYSA-N 79495 US20250388560, Compound 4 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79495 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79495&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 44640165 252656146 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123937 CSc1ccccc1-c1ccc(C(=O)N(C)CC2CCCCC2(F)F)c(S(C)(=O)=O)c1 InChI=1S/C23H27F2NO3S2/c1-26(15-17-8-6-7-13-23(17,24)25)22(27)19-12-11-16(14-21(19)31(3,28)29)18-9-4-5-10-20(18)30-2/h4-5,9-12,14,17H,6-8,13,15H2,1-3H3 VGSVRRFRPWJHRE-UHFFFAOYSA-N 79792 US20250388560, Compound 5 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79792 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79792&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 645771 252656437 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123938 CSc1ccccc1-c1ccc(C(=O)N(C)CC2(F)CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H28FNO3S2/c1-25(16-23(24)13-7-4-8-14-23)22(26)19-12-11-17(15-21(19)30(3,27)28)18-9-5-6-10-20(18)29-2/h5-6,9-12,15H,4,7-8,13-14,16H2,1-3H3 PAFGSEZHUCSUMW-UHFFFAOYSA-N 79793 US20250388560, Compound 6 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79793 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79793&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 647689 252656438 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123939 CSc1ccccc1-c1ccc(C(=O)N(C)Cc2cnoc2)c(S(C)(=O)=O)c1 InChI=1S/C20H20N2O4S2/c1-22(12-14-11-21-26-13-14)20(23)17-9-8-15(10-19(17)28(3,24)25)16-6-4-5-7-18(16)27-2/h4-11,13H,12H2,1-3H3 OULJQNGBDTVMFQ-UHFFFAOYSA-N 79794 US20250388560, Compound 7 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79794 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79794&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 649354 252656439 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123940 CCc1ccccc1CN(C)C(=O)c1ccc(-c2ccccc2SC)cc1S(C)(=O)=O InChI=1S/C25H27NO3S2/c1-5-18-10-6-7-11-20(18)17-26(2)25(27)22-15-14-19(16-24(22)31(4,28)29)21-12-8-9-13-23(21)30-3/h6-16H,5,17H2,1-4H3 UAVVJMPAGQXAGZ-UHFFFAOYSA-N 79796 US20250388560, Compound 8 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79796 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79796&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 655414 252656441 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123941 CSc1ccccc1-c1ccc(C(=O)N(C)C2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C22H27NO3S2/c1-23(17-9-5-4-6-10-17)22(24)19-14-13-16(15-21(19)28(3,25)26)18-11-7-8-12-20(18)27-2/h7-8,11-15,17H,4-6,9-10H2,1-3H3 IDVIDYSNXSKMQX-UHFFFAOYSA-N 79797 US20250388560, Compound 9 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79797 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79797&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 659228 252656442 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123942 CCC(CC)CN(C)C(=O)c1ccc(-c2ccccc2SC)cc1S(C)(=O)=O InChI=1S/C22H29NO3S2/c1-6-16(7-2)15-23(3)22(24)19-13-12-17(14-21(19)28(5,25)26)18-10-8-9-11-20(18)27-4/h8-14,16H,6-7,15H2,1-5H3 LVRIBNZLHSKCHS-UHFFFAOYSA-N 79798 US20250388560, Compound 10 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79798 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79798&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 5389465 252656443 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123943 CSc1ccccc1-c1ccc(C(=O)N(C)Cc2cc[nH]c2)c(S(C)(=O)=O)c1 InChI=1S/C21H22N2O3S2/c1-23(14-15-10-11-22-13-15)21(24)18-9-8-16(12-20(18)28(3,25)26)17-6-4-5-7-19(17)27-2/h4-13,22H,14H2,1-3H3 AGMADNWRVFXHQU-UHFFFAOYSA-N 79799 US20250388560, Compound 11 E3 ubiquitin-protein ligase TRIM21 55 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79799 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79799&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 662977 252656444 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123944 CSc1ccccc1-c1ccc(C(=O)N(C)c2ccccc2)c(S(C)(=O)=O)c1 InChI=1S/C22H21NO3S2/c1-23(17-9-5-4-6-10-17)22(24)19-14-13-16(15-21(19)28(3,25)26)18-11-7-8-12-20(18)27-2/h4-15H,1-3H3 CRRKMCCKHYCDEQ-UHFFFAOYSA-N 79801 US20250388560, Compound 12 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79801 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79801&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 665499 252656446 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123945 CSc1ccccc1-c1ccc(C(=O)N(C)CC2CN(C(C)=O)C2)c(S(C)(=O)=O)c1 InChI=1S/C22H26N2O4S2/c1-15(25)24-13-16(14-24)12-23(2)22(26)19-10-9-17(11-21(19)30(4,27)28)18-7-5-6-8-20(18)29-3/h5-11,16H,12-14H2,1-4H3 DYKKXYUXXPPYAD-UHFFFAOYSA-N 79802 US20250388560, Compound 13 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79802 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79802&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2312882 252656447 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123946 CSc1ccccc1-c1ccc(C(=O)N(C)[C@H](C)C2CCC2)c(S(C)(=O)=O)c1 InChI=1S/C22H27NO3S2/c1-15(16-8-7-9-16)23(2)22(24)19-13-12-17(14-21(19)28(4,25)26)18-10-5-6-11-20(18)27-3/h5-6,10-16H,7-9H2,1-4H3 ZZIVGNZIZDUOIQ-UHFFFAOYSA-N 79803 US20250388560, Compound 14 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79803&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2079613 252656448 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123947 CSc1ccccc1-c1ccc(C(=O)N(C)CC2CCOC2)c(S(C)(=O)=O)c1 InChI=1S/C21H25NO4S2/c1-22(13-15-10-11-26-14-15)21(23)18-9-8-16(12-20(18)28(3,24)25)17-6-4-5-7-19(17)27-2/h4-9,12,15H,10-11,13-14H2,1-3H3 DUMCIYLPFATSGK-UHFFFAOYSA-N 79804 US20250388560, Compound 15 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79804 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79804&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2124414 252656449 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123948 COc1cc(CN(C)C(=O)c2ccc(-c3ccccc3SC)cc2S(C)(=O)=O)ccn1 InChI=1S/C23H24N2O4S2/c1-25(15-16-11-12-24-22(13-16)29-2)23(26)19-10-9-17(14-21(19)31(4,27)28)18-7-5-6-8-20(18)30-3/h5-14H,15H2,1-4H3 SPWJXKXEBMZOMX-UHFFFAOYSA-N 79808 US20250388560, Compound 16 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79808 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79808&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 976322 252656453 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123949 CSc1cc(F)ccc1-c1ccc(C(=O)N(C)CC2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H28FNO3S2/c1-25(15-16-7-5-4-6-8-16)23(26)20-11-9-17(13-22(20)30(3,27)28)19-12-10-18(24)14-21(19)29-2/h9-14,16H,4-8,15H2,1-3H3 MEFAYSLODGHXPL-UHFFFAOYSA-N 79809 US20250388560, Compound 17 E3 ubiquitin-protein ligase TRIM21 55 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79809&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2983047 252656454 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123950 CSc1ccccc1-c1ccc(C(=O)N(C)Cc2cc[nH]c(=O)c2)c(S(C)(=O)=O)c1 InChI=1S/C22H22N2O4S2/c1-24(14-15-10-11-23-21(25)12-15)22(26)18-9-8-16(13-20(18)30(3,27)28)17-6-4-5-7-19(17)29-2/h4-13H,14H2,1-3H3,(H,23,25) KUAWQHSPKBYTCH-UHFFFAOYSA-N 79811 US20250388560, Compound 18 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79811&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 749132 252656456 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123951 CSc1ccccc1-c1ccc(C(=O)N(C)[C@H](C)C2CC2)c(S(C)(=O)=O)c1 InChI=1S/C21H25NO3S2/c1-14(15-9-10-15)22(2)21(23)18-12-11-16(13-20(18)27(4,24)25)17-7-5-6-8-19(17)26-3/h5-8,11-15H,9-10H2,1-4H3 WFABGQPUMXWNFN-UHFFFAOYSA-N 79812 US20250388560, Compound 19 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79812 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79812&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 3155707 252656457 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123952 CSc1ccccc1-c1ccc(C(=O)N(C)[C@H](C)C2CCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H29NO3S2/c1-16(17-9-5-6-10-17)24(2)23(25)20-14-13-18(15-22(20)29(4,26)27)19-11-7-8-12-21(19)28-3/h7-8,11-17H,5-6,9-10H2,1-4H3 KVWHJBASHFYUIN-UHFFFAOYSA-N 79814 US20250388560, Compound 20 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79814&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 91898283 252656459 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123953 CSc1ccccc1-c1ccc(C(=O)N(C)CCN2CCOCC2)c(S(C)(=O)=O)c1 InChI=1S/C22H28N2O4S2/c1-23(10-11-24-12-14-28-15-13-24)22(25)19-9-8-17(16-21(19)30(3,26)27)18-6-4-5-7-20(18)29-2/h4-9,16H,10-15H2,1-3H3 HEKAEIWDBWGYHN-UHFFFAOYSA-N 79815 US20250388560, Compound 21 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79815&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 5405772 252656460 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123954 CSc1ccccc1-c1ccc(C(=O)N(C)CCN2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H30N2O3S2/c1-24(15-16-25-13-7-4-8-14-25)23(26)20-12-11-18(17-22(20)30(3,27)28)19-9-5-6-10-21(19)29-2/h5-6,9-12,17H,4,7-8,13-16H2,1-3H3 VMHMDDVBGUIIQT-UHFFFAOYSA-N 79816 US20250388560, Compound 22 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79816 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79816&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 5310837 252656461 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123955 CSc1ccccc1-c1ccc(C(=O)N(C)CC2CCOCC2)c(S(C)(=O)=O)c1 InChI=1S/C22H27NO4S2/c1-23(15-16-10-12-27-13-11-16)22(24)19-9-8-17(14-21(19)29(3,25)26)18-6-4-5-7-20(18)28-2/h4-9,14,16H,10-13,15H2,1-3H3 RGGDKBADIJPRBC-UHFFFAOYSA-N 79821 US20250388560, Compound 23 E3 ubiquitin-protein ligase TRIM21 55 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79821 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79821&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 1888033 252656466 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123956 COc1ccccc1-c1ccc(C(=O)N(C)[C@H](C)C2CCC2)c(S(C)(=O)=O)c1 InChI=1S/C22H27NO4S/c1-15(16-8-7-9-16)23(2)22(24)19-13-12-17(14-21(19)28(4,25)26)18-10-5-6-11-20(18)27-3/h5-6,10-16H,7-9H2,1-4H3 SQBMOEWTAAWSPK-UHFFFAOYSA-N 79822 US20250388560, Compound 24 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79822 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79822&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 1441513 252656467 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123957 COc1ccccc1-c1ccc(C(=O)N(C)CC2CCOC2)c(S(C)(=O)=O)c1 InChI=1S/C21H25NO5S/c1-22(13-15-10-11-27-14-15)21(23)18-9-8-16(12-20(18)28(3,24)25)17-6-4-5-7-19(17)26-2/h4-9,12,15H,10-11,13-14H2,1-3H3 GYTIJUPUHORZDI-UHFFFAOYSA-N 79824 US20250388560, Compound 25 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79824 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79824&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 4420032 252656469 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123958 COc1ccccc1-c1ccc(C(=O)N(C)CC2CN(C(C)=O)C2)c(S(C)(=O)=O)c1 InChI=1S/C22H26N2O5S/c1-15(25)24-13-16(14-24)12-23(2)22(26)19-10-9-17(11-21(19)30(4,27)28)18-7-5-6-8-20(18)29-3/h5-11,16H,12-14H2,1-4H3 NWKBNVOGPJFRBK-UHFFFAOYSA-N 79825 US20250388560, Compound 26 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79825 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79825&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2961359 252656470 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123959 COc1cc(CN(C)C(=O)c2ccc(-c3ccccc3OC)cc2S(C)(=O)=O)ccn1 InChI=1S/C23H24N2O5S/c1-25(15-16-11-12-24-22(13-16)30-3)23(26)19-10-9-17(14-21(19)31(4,27)28)18-7-5-6-8-20(18)29-2/h5-14H,15H2,1-4H3 UWJRXEZKGQYGTG-UHFFFAOYSA-N 79826 US20250388560, Compound 27 E3 ubiquitin-protein ligase TRIM21 55 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79826 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79826&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 91898284 252656471 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123960 COc1ccccc1-c1ccc(C(=O)N(C)Cc2cc[nH]c(=O)c2)c(S(C)(=O)=O)c1 InChI=1S/C22H22N2O5S/c1-24(14-15-10-11-23-21(25)12-15)22(26)18-9-8-16(13-20(18)30(3,27)28)17-6-4-5-7-19(17)29-2/h4-13H,14H2,1-3H3,(H,23,25) YMLDNEIAWVKWTR-UHFFFAOYSA-N 79827 US20250388560, Compound 28 E3 ubiquitin-protein ligase TRIM21 55 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79827 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79827&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 5013043 252656472 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123961 COc1ccccc1-c1ccc(C(=O)N(C)Cc2cc[nH]c2)c(S(C)(=O)=O)c1 InChI=1S/C21H22N2O4S/c1-23(14-15-10-11-22-13-15)21(24)18-9-8-16(12-20(18)28(3,25)26)17-6-4-5-7-19(17)27-2/h4-13,22H,14H2,1-3H3 AHJDOXSABIIXGG-UHFFFAOYSA-N 79828 US20250388560, Compound 29 E3 ubiquitin-protein ligase TRIM21 55 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79828 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79828&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2866938 252656473 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123962 COc1ccccc1-c1ccc(C(=O)N(C)CC2COC2)c(S(C)(=O)=O)c1 InChI=1S/C20H23NO5S/c1-21(11-14-12-26-13-14)20(22)17-9-8-15(10-19(17)27(3,23)24)16-6-4-5-7-18(16)25-2/h4-10,14H,11-13H2,1-3H3 OVKNFJUTLVQZLK-UHFFFAOYSA-N 79829 US20250388560, Compound 30 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79829 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79829&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 4438402 252656474 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123963 COc1ccccc1-c1ccc(C(=O)N(C)C(C)C2COC2)c(S(C)(=O)=O)c1 InChI=1S/C21H25NO5S/c1-14(16-12-27-13-16)22(2)21(23)18-10-9-15(11-20(18)28(4,24)25)17-7-5-6-8-19(17)26-3/h5-11,14,16H,12-13H2,1-4H3 VWIRUWVDJSAGDG-UHFFFAOYSA-N 79831 US20250388560, Compound 31 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79831 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79831&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2105000 252656476 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123964 COc1ccccc1-c1ccc(C(=O)N(C)[C@H](C)C2CC2)c(S(C)(=O)=O)c1 InChI=1S/C21H25NO4S/c1-14(15-9-10-15)22(2)21(23)18-12-11-16(13-20(18)27(4,24)25)17-7-5-6-8-19(17)26-3/h5-8,11-15H,9-10H2,1-4H3 APNNSVWCQUYDDJ-UHFFFAOYSA-N 79835 US20250388560, Compound 32 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79835 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79835&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 6876815 252656480 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123965 COc1ccccc1-c1ccc(C(=O)N(C)[C@H](C)C2CCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H29NO4S/c1-16(17-9-5-6-10-17)24(2)23(25)20-14-13-18(15-22(20)29(4,26)27)19-11-7-8-12-21(19)28-3/h7-8,11-17H,5-6,9-10H2,1-4H3 FMOBJQANNICIJQ-UHFFFAOYSA-N 79836 US20250388560, Compound 33 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79836 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79836&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 91898285 252656481 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123966 COc1ccccc1-c1ccc(C(=O)N(C)CC2CCOCC2)c(S(C)(=O)=O)c1 InChI=1S/C22H27NO5S/c1-23(15-16-10-12-28-13-11-16)22(24)19-9-8-17(14-21(19)29(3,25)26)18-6-4-5-7-20(18)27-2/h4-9,14,16H,10-13,15H2,1-3H3 XBQLQFZWXKLWPA-UHFFFAOYSA-N 79837 US20250388560, Compound 34 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79837 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79837&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 1454979 252656482 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123967 COc1ccccc1-c1ccc(C(=O)N(C)CC2CCC(O)CC2)c(S(C)(=O)=O)c1 InChI=1S/C23H29NO5S/c1-24(15-16-8-11-18(25)12-9-16)23(26)20-13-10-17(14-22(20)30(3,27)28)19-6-4-5-7-21(19)29-2/h4-7,10,13-14,16,18,25H,8-9,11-12,15H2,1-3H3 ITPZIGITQLGUCB-UHFFFAOYSA-N 79839 US20250388560, Compound 35 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79839 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79839&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 1717232 252656484 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123968 CN(CC1CCCCC1)C(=O)c1ccc(C2CCCCC2)cc1S(C)(=O)=O InChI=1S/C22H33NO3S/c1-23(16-17-9-5-3-6-10-17)22(24)20-14-13-19(15-21(20)27(2,25)26)18-11-7-4-8-12-18/h13-15,17-18H,3-12,16H2,1-2H3 XCZJKLYGPUCTMM-UHFFFAOYSA-N 79840 US20250388560, Compound 36 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79840 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79840&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 4YK 5C1Q 5091486 252656485 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123969 COc1ccccc1-c1ccc(C(=O)N(C)CC2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H29NO4S/c1-24(16-17-9-5-4-6-10-17)23(25)20-14-13-18(15-22(20)29(3,26)27)19-11-7-8-12-21(19)28-2/h7-8,11-15,17H,4-6,9-10,16H2,1-3H3 HFWIJKFIAUJRTR-UHFFFAOYSA-N 79841 US20250388560, Compound 37 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79841 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79841&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 947342 252656486 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123970 Cc1ccccc1-c1ccc(C(=O)N(C)CC2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H29NO3S/c1-17-9-7-8-12-20(17)19-13-14-21(22(15-19)28(3,26)27)23(25)24(2)16-18-10-5-4-6-11-18/h7-9,12-15,18H,4-6,10-11,16H2,1-3H3 LSONEZGOOGHRIG-UHFFFAOYSA-N 79842 US20250388560, Compound 38 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79842 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79842&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2830086 252656487 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123971 CN(CC1CCCCC1)C(=O)c1ccc(-c2ccccc2C(F)(F)F)cc1S(C)(=O)=O InChI=1S/C23H26F3NO3S/c1-27(15-16-8-4-3-5-9-16)22(28)19-13-12-17(14-21(19)31(2,29)30)18-10-6-7-11-20(18)23(24,25)26/h6-7,10-14,16H,3-5,8-9,15H2,1-2H3 OHXIEFSDMMLOBE-UHFFFAOYSA-N 79843 US20250388560, Compound 39 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79843 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79843&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 682575 252656488 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123972 CN(CC1CCCCC1)C(=O)c1ccc(-c2ccccc2N(C)C)cc1S(C)(=O)=O InChI=1S/C24H32N2O3S/c1-25(2)22-13-9-8-12-20(22)19-14-15-21(23(16-19)30(4,28)29)24(27)26(3)17-18-10-6-5-7-11-18/h8-9,12-16,18H,5-7,10-11,17H2,1-4H3 JIVGFJLNYZQMSO-UHFFFAOYSA-N 79844 US20250388560, Compound 40 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79844 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79844&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 1327610 252656489 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123973 CN(CC1CCCCC1)C(=O)c1ccc(-c2ccc(F)cc2C2CC2)cc1S(C)(=O)=O InChI=1S/C25H30FNO3S/c1-27(16-17-6-4-3-5-7-17)25(28)22-12-10-19(14-24(22)31(2,29)30)21-13-11-20(26)15-23(21)18-8-9-18/h10-15,17-18H,3-9,16H2,1-2H3 KWYWMVMFMILSAU-UHFFFAOYSA-N 79845 US20250388560, Compound 41 E3 ubiquitin-protein ligase TRIM21 55 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79845 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79845&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 5723855 252656490 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123974 CN(CC1CCCCC1)C(=O)c1ccc(-c2ccccc2C(C)(C)O)cc1S(C)(=O)=O InChI=1S/C25H33NO4S/c1-25(2,28)22-13-9-8-12-20(22)19-14-15-21(23(16-19)31(4,29)30)24(27)26(3)17-18-10-6-5-7-11-18/h8-9,12-16,18,28H,5-7,10-11,17H2,1-4H3 VLVTWXALJFIRIP-UHFFFAOYSA-N 79846 US20250388560, Compound 42 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79846 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79846&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2212798 252656491 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123975 COc1cnccc1-c1ccc(C(=O)N(C)CC2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C22H28N2O4S/c1-24(15-16-7-5-4-6-8-16)22(25)19-10-9-17(13-21(19)29(3,26)27)18-11-12-23-14-20(18)28-2/h9-14,16H,4-8,15H2,1-3H3 YWTVLNMUORWBGP-UHFFFAOYSA-N 79847 US20250388560, Compound 43 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79847 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79847&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 1725739 252656492 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123976 Cc1cccc(-c2ccc(C(=O)N(C)CC3CCCCC3)c(S(C)(=O)=O)c2)c1 InChI=1S/C23H29NO3S/c1-17-8-7-11-19(14-17)20-12-13-21(22(15-20)28(3,26)27)23(25)24(2)16-18-9-5-4-6-10-18/h7-8,11-15,18H,4-6,9-10,16H2,1-3H3 BJJNHAWSHJLARE-UHFFFAOYSA-N 79848 US20250388560, Compound 44 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79848 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79848&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 12004452 252656493 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123977 CN(CC1CCCCC1)C(=O)c1ccc(-c2ccccc2F)cc1S(C)(=O)=O InChI=1S/C22H26FNO3S/c1-24(15-16-8-4-3-5-9-16)22(25)19-13-12-17(14-21(19)28(2,26)27)18-10-6-7-11-20(18)23/h6-7,10-14,16H,3-5,8-9,15H2,1-2H3 UKEYDPROJHHPRK-UHFFFAOYSA-N 79849 US20250388560, Compound 45 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79849 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79849&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2942839 252656494 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123978 CC(C)c1ccccc1-c1ccc(C(=O)N(C)CC2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C25H33NO3S/c1-18(2)21-12-8-9-13-22(21)20-14-15-23(24(16-20)30(4,28)29)25(27)26(3)17-19-10-6-5-7-11-19/h8-9,12-16,18-19H,5-7,10-11,17H2,1-4H3 HTVYMVWLQLCJOE-UHFFFAOYSA-N 79850 US20250388560, Compound 46 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79850 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79850&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 1813635 252656495 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123979 CN(CC1CCCCC1)C(=O)c1ccc(-c2cccc3ccoc23)cc1S(C)(=O)=O InChI=1S/C24H27NO4S/c1-25(16-17-7-4-3-5-8-17)24(26)21-12-11-19(15-22(21)30(2,27)28)20-10-6-9-18-13-14-29-23(18)20/h6,9-15,17H,3-5,7-8,16H2,1-2H3 IRWSPMAVWADGEK-UHFFFAOYSA-N 79851 US20250388560, Compound 47 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79851 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79851&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 74444428 252656496 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123980 CN(CC1CCCCC1)C(=O)c1ccc(-c2cccc3occc23)cc1S(C)(=O)=O InChI=1S/C24H27NO4S/c1-25(16-17-7-4-3-5-8-17)24(26)21-12-11-18(15-23(21)30(2,27)28)19-9-6-10-22-20(19)13-14-29-22/h6,9-15,17H,3-5,7-8,16H2,1-2H3 MVOXSCAIQFRBCQ-UHFFFAOYSA-N 79852 US20250388560, Compound 48 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79852 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79852&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 6862122 252656497 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123981 CN(CC1CCCCC1)C(=O)c1ccc(-c2cccc(C3CC3)c2)cc1S(C)(=O)=O InChI=1S/C25H31NO3S/c1-26(17-18-7-4-3-5-8-18)25(27)23-14-13-22(16-24(23)30(2,28)29)21-10-6-9-20(15-21)19-11-12-19/h6,9-10,13-16,18-19H,3-5,7-8,11-12,17H2,1-2H3 FUERXFPEPKIPMT-UHFFFAOYSA-N 79853 US20250388560, Compound 49 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79853 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79853&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 12004912 252656498 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123982 CN(CC1CCCCC1)C(=O)c1ccc(-c2cccc3[nH]ccc23)cc1S(C)(=O)=O InChI=1S/C24H28N2O3S/c1-26(16-17-7-4-3-5-8-17)24(27)21-12-11-18(15-23(21)30(2,28)29)19-9-6-10-22-20(19)13-14-25-22/h6,9-15,17,25H,3-5,7-8,16H2,1-2H3 OOEFAZXWWJUULD-UHFFFAOYSA-N 79854 US20250388560, Compound 50 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79854 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79854&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 12005034 252656499 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123983 CN(CC1CCCCC1)C(=O)c1ccc(-c2cccc3cc[nH]c23)cc1S(C)(=O)=O InChI=1S/C24H28N2O3S/c1-26(16-17-7-4-3-5-8-17)24(27)21-12-11-19(15-22(21)30(2,28)29)20-10-6-9-18-13-14-25-23(18)20/h6,9-15,17,25H,3-5,7-8,16H2,1-2H3 PSCYOYGWNBASED-UHFFFAOYSA-N 79855 US20250388560, Compound 51 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79855 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79855&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 1719534 252656500 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123984 COc1cc(F)ccc1-c1ccc(C(=O)N(C)CC2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C23H28FNO4S/c1-25(15-16-7-5-4-6-8-16)23(26)20-11-9-17(13-22(20)30(3,27)28)19-12-10-18(24)14-21(19)29-2/h9-14,16H,4-8,15H2,1-3H3 RWZONWSJBFBUKO-UHFFFAOYSA-N 79857 US20250388560, Compound 52 E3 ubiquitin-protein ligase TRIM21 <10 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79857 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79857&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 6533320 252656502 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123985 CCc1ccccc1-c1ccc(C(=O)N(C)CC2CCCCC2)c(S(C)(=O)=O)c1 InChI=1S/C24H31NO3S/c1-4-19-12-8-9-13-21(19)20-14-15-22(23(16-20)29(3,27)28)24(26)25(2)17-18-10-6-5-7-11-18/h8-9,12-16,18H,4-7,10-11,17H2,1-3H3 LYDQJVGTBRHFFK-UHFFFAOYSA-N 79858 US20250388560, Compound 53 E3 ubiquitin-protein ligase TRIM21 550 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79858 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79858&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2529706 252656503 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123986 CN(CC1CCCCC1)C(=O)c1ccc(-c2ccc(F)cc2)cc1S(C)(=O)=O InChI=1S/C22H26FNO3S/c1-24(15-16-6-4-3-5-7-16)22(25)20-13-10-18(14-21(20)28(2,26)27)17-8-11-19(23)12-9-17/h8-14,16H,3-7,15H2,1-2H3 VFTFVQLZOMOEGP-UHFFFAOYSA-N 79859 US20250388560, Compound 54 E3 ubiquitin-protein ligase TRIM21 5500 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79859&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 6291421 252656504 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123987 CSc1cc(F)ccc1-c1ccc(C(=O)N(C)CC2CCOCC2)c(S(C)(=O)=O)c1 InChI=1S/C22H26FNO4S2/c1-24(14-15-8-10-28-11-9-15)22(25)19-6-4-16(12-21(19)30(3,26)27)18-7-5-17(23)13-20(18)29-2/h4-7,12-13,15H,8-11,14H2,1-3H3 FALBTADCQHZIMC-UHFFFAOYSA-N 79860 US20250388560, Compound 55 E3 ubiquitin-protein ligase TRIM21 <10 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79860 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79860&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 15945167 252656505 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123988 CSc1cc(F)ccc1-c1ccc(C(=O)N(C)Cc2cc[nH]c(=O)c2)c(S(C)(=O)=O)c1 InChI=1S/C22H21FN2O4S2/c1-25(13-14-8-9-24-21(26)10-14)22(27)18-6-4-15(11-20(18)31(3,28)29)17-7-5-16(23)12-19(17)30-2/h4-12H,13H2,1-3H3,(H,24,26) XRHYOWJRSOGGGC-UHFFFAOYSA-N 79861 US20250388560, Compound 56 E3 ubiquitin-protein ligase TRIM21 <10 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79861 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79861&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 6223700 252656506 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123989 COc1cc(F)ccc1-c1ccc(C(=O)N(C)Cc2cc[nH]c(=O)c2)c(S(C)(=O)=O)c1 InChI=1S/C22H21FN2O5S/c1-25(13-14-8-9-24-21(26)10-14)22(27)18-6-4-15(11-20(18)31(3,28)29)17-7-5-16(23)12-19(17)30-2/h4-12H,13H2,1-3H3,(H,24,26) SHXKYGZKGCTDJE-UHFFFAOYSA-N 79862 US20250388560, Compound 57 E3 ubiquitin-protein ligase TRIM21 <10 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79862 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79862&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 2478417 252656507 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8 123990 CN(CC1CCCCC1)C(=O)c1ccc(-c2ccccc2)cc1S(C)(=O)=O InChI=1S/C22H27NO3S/c1-23(16-17-9-5-3-6-10-17)22(24)20-14-13-19(15-21(20)27(2,25)26)18-11-7-4-8-12-18/h4,7-8,11-15,17H,3,5-6,9-10,16H2,1-2H3 QETZAONDANKXJO-UHFFFAOYSA-N 79864 US20250388560, Compound 58 E3 ubiquitin-protein ligase TRIM21 >10000 US Patent 10.7270/Q2VT1XX9 US20250388560 LI, J; WANG, Q; WANG, X; LI, X; DOU, D; MENG, X; LI, X; CHEN, Q; GUO, A; ZHENG, N; HU, H; HE, W 12/25/2025 5/6/2026 Hitgen http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79864 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2083&target=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79864&enzyme=E3+ubiquitin-protein+ligase+TRIM21&column=ki&startPg=0&Increment=50&submit=Search 3320490 252656509 1 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY 9Q9R,9Q9Q,9Q9P,9Q9O,9M3N,2IWG,9QBA,9II5,5OLM,6FGA,7BBD,8A58,6S53,5JPX E3 ubiquitin-protein ligase TRIM21 RO52_HUMAN P19474 Q5XPV5 Q96RF8