BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
123991	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)C(O)c1ccccc1	InChI=1S/C32H29FN4O4/c1-17-27(34-19(3)28(17)37-32(41)29(38)21-7-5-4-6-8-21)16-25-24-15-22(11-14-26(24)36-31(25)40)30(39)35-18(2)20-9-12-23(33)13-10-20/h4-16,18,29,34,38H,1-3H3,(H,35,39)(H,36,40)(H,37,41)	ZKZQFRMBOYSLNH-UHFFFAOYSA-N	79865	US20250388567, Compound 1	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79865&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			5237327	252656510							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123992	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)C(O)c1ccccc1	InChI=1S/C32H29FN4O4/c1-17-27(34-19(3)28(17)37-32(41)29(38)21-7-5-4-6-8-21)16-25-24-15-22(11-14-26(24)36-31(25)40)30(39)35-18(2)20-9-12-23(33)13-10-20/h4-16,18,29,34,38H,1-3H3,(H,35,39)(H,36,40)(H,37,41)	ZKZQFRMBOYSLNH-UHFFFAOYSA-N	79865	US20250388567, Compound 1	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79865&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			5237327	252656510							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
123993	COc1cccc2[nH]c(CC(=O)Nc3c(C)[nH]c(/C=C4\C(=O)Nc5ccc(C(=O)N[C@H](C)c6ccc(F)cc6)cc54)c3C)cc12	InChI=1S/C35H32FN5O4/c1-18-30(37-20(3)33(18)41-32(42)16-24-15-27-28(39-24)6-5-7-31(27)45-4)17-26-25-14-22(10-13-29(25)40-35(26)44)34(43)38-19(2)21-8-11-23(36)12-9-21/h5-15,17,19,37,39H,16H2,1-4H3,(H,38,43)(H,40,44)(H,41,42)	WSWNCVPIANZUKG-UHFFFAOYSA-N	79866	US20250388567, Compound 2	G protein-coupled receptor kinase 5	Homo sapiens		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79866&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			5774232	252656511							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123994	COc1cccc2[nH]c(CC(=O)Nc3c(C)[nH]c(/C=C4\C(=O)Nc5ccc(C(=O)N[C@H](C)c6ccc(F)cc6)cc54)c3C)cc12	InChI=1S/C35H32FN5O4/c1-18-30(37-20(3)33(18)41-32(42)16-24-15-27-28(39-24)6-5-7-31(27)45-4)17-26-25-14-22(10-13-29(25)40-35(26)44)34(43)38-19(2)21-8-11-23(36)12-9-21/h5-15,17,19,37,39H,16H2,1-4H3,(H,38,43)(H,40,44)(H,41,42)	WSWNCVPIANZUKG-UHFFFAOYSA-N	79866	US20250388567, Compound 2	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79866&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			5774232	252656511							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
123995	COc1cccc2[nH]c(C(=O)C(=O)Nc3c(C)[nH]c(/C=C4\C(=O)Nc5ccc(C(=O)N[C@H](C)c6ccc(F)cc6)cc54)c3C)cc12	InChI=1S/C35H30FN5O5/c1-17-28(37-19(3)31(17)41-35(45)32(42)29-16-25-26(39-29)6-5-7-30(25)46-4)15-24-23-14-21(10-13-27(23)40-34(24)44)33(43)38-18(2)20-8-11-22(36)12-9-20/h5-16,18,37,39H,1-4H3,(H,38,43)(H,40,44)(H,41,45)	PQWDUQPPDPKCKU-UHFFFAOYSA-N	79867	US20250388567, Compound 3	G protein-coupled receptor kinase 5	Homo sapiens		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79867&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			6898433	252656512							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123996	COc1cccc2[nH]c(C(=O)C(=O)Nc3c(C)[nH]c(/C=C4\C(=O)Nc5ccc(C(=O)N[C@H](C)c6ccc(F)cc6)cc54)c3C)cc12	InChI=1S/C35H30FN5O5/c1-17-28(37-19(3)31(17)41-35(45)32(42)29-16-25-26(39-29)6-5-7-30(25)46-4)15-24-23-14-21(10-13-27(23)40-34(24)44)33(43)38-18(2)20-8-11-22(36)12-9-20/h5-16,18,37,39H,1-4H3,(H,38,43)(H,40,44)(H,41,45)	PQWDUQPPDPKCKU-UHFFFAOYSA-N	79867	US20250388567, Compound 3	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79867&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			6898433	252656512							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
123997	COc1cccc2[nH]c(C(O)C(=O)Nc3c(C)[nH]c(/C=C4\C(=O)Nc5ccc(C(=O)N[C@H](C)c6ccc(F)cc6)cc54)c3C)cc12	InChI=1S/C35H32FN5O5/c1-17-28(37-19(3)31(17)41-35(45)32(42)29-16-25-26(39-29)6-5-7-30(25)46-4)15-24-23-14-21(10-13-27(23)40-34(24)44)33(43)38-18(2)20-8-11-22(36)12-9-20/h5-16,18,32,37,39,42H,1-4H3,(H,38,43)(H,40,44)(H,41,45)	FWSPUBVZCLBBCF-UHFFFAOYSA-N	79868	US20250388567, Compound 4	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79868&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			5740575	252656513							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
123998	COc1cccc2[nH]c(C(O)C(=O)Nc3c(C)[nH]c(/C=C4\C(=O)Nc5ccc(C(=O)N[C@H](C)c6ccc(F)cc6)cc54)c3C)cc12	InChI=1S/C35H32FN5O5/c1-17-28(37-19(3)31(17)41-35(45)32(42)29-16-25-26(39-29)6-5-7-30(25)46-4)15-24-23-14-21(10-13-27(23)40-34(24)44)33(43)38-18(2)20-8-11-22(36)12-9-20/h5-16,18,32,37,39,42H,1-4H3,(H,38,43)(H,40,44)(H,41,45)	FWSPUBVZCLBBCF-UHFFFAOYSA-N	79868	US20250388567, Compound 4	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79868&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			5740575	252656513							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
123999	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@@H]1c2ccccc2C[C@@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	LTCXBRMXULZIRU-UHFFFAOYSA-N	79869	US20250388567, Compound 5	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79869&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			5853451	252656514							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124000	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@@H]1c2ccccc2C[C@@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	LTCXBRMXULZIRU-UHFFFAOYSA-N	79869	US20250388567, Compound 5	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79869&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			5853451	252656514							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124001	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@@H]1c2ccccc2C[C@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	LTCXBRMXULZIRU-UHFFFAOYSA-N	79870	US20250388567, Compound 6	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79870&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			4228026	252656515							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124002	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@@H]1c2ccccc2C[C@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	LTCXBRMXULZIRU-UHFFFAOYSA-N	79870	US20250388567, Compound 6	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79870&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			4228026	252656515							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124003	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1c2ccccc2C[C@@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	LTCXBRMXULZIRU-UHFFFAOYSA-N	79871	US20250388567, Compound 7	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79871&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			738234	252656516							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124004	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1c2ccccc2C[C@@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	LTCXBRMXULZIRU-UHFFFAOYSA-N	79871	US20250388567, Compound 7	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79871&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			738234	252656516							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124005	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1c2ccccc2C[C@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	LTCXBRMXULZIRU-UHFFFAOYSA-N	79872	US20250388567, Compound 8	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79872&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			3289794	252656517							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124006	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1c2ccccc2C[C@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	LTCXBRMXULZIRU-UHFFFAOYSA-N	79872	US20250388567, Compound 8	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79872&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			3289794	252656517							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124007	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@@H]4CCc5ccccc54)cc32)c(C)c1NC(=O)C(=O)c1ccco1	InChI=1S/C31H26N4O5/c1-16-25(32-17(2)27(16)35-31(39)28(36)26-8-5-13-40-26)15-22-21-14-19(10-12-24(21)34-30(22)38)29(37)33-23-11-9-18-6-3-4-7-20(18)23/h3-8,10,12-15,23,32H,9,11H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)	FVDWXNSIAFVMMB-UHFFFAOYSA-N	79873	US20250388567, Compound 9	G protein-coupled receptor kinase 5	Homo sapiens		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79873&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			1087077	252656518							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124008	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@@H]4CCc5ccccc54)cc32)c(C)c1NC(=O)C(=O)c1ccco1	InChI=1S/C31H26N4O5/c1-16-25(32-17(2)27(16)35-31(39)28(36)26-8-5-13-40-26)15-22-21-14-19(10-12-24(21)34-30(22)38)29(37)33-23-11-9-18-6-3-4-7-20(18)23/h3-8,10,12-15,23,32H,9,11H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)	FVDWXNSIAFVMMB-UHFFFAOYSA-N	79873	US20250388567, Compound 9	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79873&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			1087077	252656518							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124009	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@@H]4CCc5ccccc54)cc32)c(C)c1NC(=O)C(O)c1ccco1	InChI=1S/C31H28N4O5/c1-16-25(32-17(2)27(16)35-31(39)28(36)26-8-5-13-40-26)15-22-21-14-19(10-12-24(21)34-30(22)38)29(37)33-23-11-9-18-6-3-4-7-20(18)23/h3-8,10,12-15,23,28,32,36H,9,11H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)	MBVKANCNIGPKOK-UHFFFAOYSA-N	79874	US20250388567, Compound 10	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79874&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			9692483	252656519							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124010	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@@H]4CCc5ccccc54)cc32)c(C)c1NC(=O)C(O)c1ccco1	InChI=1S/C31H28N4O5/c1-16-25(32-17(2)27(16)35-31(39)28(36)26-8-5-13-40-26)15-22-21-14-19(10-12-24(21)34-30(22)38)29(37)33-23-11-9-18-6-3-4-7-20(18)23/h3-8,10,12-15,23,28,32,36H,9,11H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)	MBVKANCNIGPKOK-UHFFFAOYSA-N	79874	US20250388567, Compound 10	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79874&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			9692483	252656519							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124011	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H]4CCc5ccccc54)cc32)c(C)c1NC(=O)C(=O)c1ccco1	InChI=1S/C31H26N4O5/c1-16-25(32-17(2)27(16)35-31(39)28(36)26-8-5-13-40-26)15-22-21-14-19(10-12-24(21)34-30(22)38)29(37)33-23-11-9-18-6-3-4-7-20(18)23/h3-8,10,12-15,23,32H,9,11H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)	FVDWXNSIAFVMMB-UHFFFAOYSA-N	79875	US20250388567, Compound 11	G protein-coupled receptor kinase 5	Homo sapiens		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79875&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			7205716	252656520							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124012	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H]4CCc5ccccc54)cc32)c(C)c1NC(=O)C(=O)c1ccco1	InChI=1S/C31H26N4O5/c1-16-25(32-17(2)27(16)35-31(39)28(36)26-8-5-13-40-26)15-22-21-14-19(10-12-24(21)34-30(22)38)29(37)33-23-11-9-18-6-3-4-7-20(18)23/h3-8,10,12-15,23,32H,9,11H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)	FVDWXNSIAFVMMB-UHFFFAOYSA-N	79875	US20250388567, Compound 11	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79875&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			7205716	252656520							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124013	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H]4CCc5ccccc54)cc32)c(C)c1NC(=O)C(O)c1ccco1	InChI=1S/C31H28N4O5/c1-16-25(32-17(2)27(16)35-31(39)28(36)26-8-5-13-40-26)15-22-21-14-19(10-12-24(21)34-30(22)38)29(37)33-23-11-9-18-6-3-4-7-20(18)23/h3-8,10,12-15,23,28,32,36H,9,11H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)	MBVKANCNIGPKOK-UHFFFAOYSA-N	79876	US20250388567, Compound 12	G protein-coupled receptor kinase 5	Homo sapiens		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79876&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			7205744	252656521							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124014	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H]4CCc5ccccc54)cc32)c(C)c1NC(=O)C(O)c1ccco1	InChI=1S/C31H28N4O5/c1-16-25(32-17(2)27(16)35-31(39)28(36)26-8-5-13-40-26)15-22-21-14-19(10-12-24(21)34-30(22)38)29(37)33-23-11-9-18-6-3-4-7-20(18)23/h3-8,10,12-15,23,28,32,36H,9,11H2,1-2H3,(H,33,37)(H,34,38)(H,35,39)	MBVKANCNIGPKOK-UHFFFAOYSA-N	79876	US20250388567, Compound 12	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79876&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			7205744	252656521							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124015	Cc1[nH]c(CC2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)[C@H](O)c1ccco1	InChI=1S/C30H29FN4O5/c1-15-24(32-17(3)26(15)35-30(39)27(36)25-5-4-12-40-25)14-22-21-13-19(8-11-23(21)34-29(22)38)28(37)33-16(2)18-6-9-20(31)10-7-18/h4-13,16,22,27,32,36H,14H2,1-3H3,(H,33,37)(H,34,38)(H,35,39)	VDADIGRTGBLANI-UHFFFAOYSA-N	79877	US20250388567, Compound 13	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79877&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			1471594	252656522							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124016	Cc1[nH]c(CC2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)[C@H](O)c1ccco1	InChI=1S/C30H29FN4O5/c1-15-24(32-17(3)26(15)35-30(39)27(36)25-5-4-12-40-25)14-22-21-13-19(8-11-23(21)34-29(22)38)28(37)33-16(2)18-6-9-20(31)10-7-18/h4-13,16,22,27,32,36H,14H2,1-3H3,(H,33,37)(H,34,38)(H,35,39)	VDADIGRTGBLANI-UHFFFAOYSA-N	79877	US20250388567, Compound 13	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79877&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			1471594	252656522							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124017	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)[C@@H](O)c1ccco1	InChI=1S/C30H27FN4O5/c1-15-24(32-17(3)26(15)35-30(39)27(36)25-5-4-12-40-25)14-22-21-13-19(8-11-23(21)34-29(22)38)28(37)33-16(2)18-6-9-20(31)10-7-18/h4-14,16,27,32,36H,1-3H3,(H,33,37)(H,34,38)(H,35,39)	XSBCFLGDNDHVIP-UHFFFAOYSA-N	79878	US20250388567, Compound 14	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79878&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	W3F	8UAQ,9BRE	1477883	242053727							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124018	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)[C@@H](O)c1ccco1	InChI=1S/C30H27FN4O5/c1-15-24(32-17(3)26(15)35-30(39)27(36)25-5-4-12-40-25)14-22-21-13-19(8-11-23(21)34-29(22)38)28(37)33-16(2)18-6-9-20(31)10-7-18/h4-14,16,27,32,36H,1-3H3,(H,33,37)(H,34,38)(H,35,39)	XSBCFLGDNDHVIP-UHFFFAOYSA-N	79878	US20250388567, Compound 14	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79878&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	W3F	8UAQ,9BRE	1477883	242053727							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124019	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)[C@H](O)c1ccco1	InChI=1S/C30H27FN4O5/c1-15-24(32-17(3)26(15)35-30(39)27(36)25-5-4-12-40-25)14-22-21-13-19(8-11-23(21)34-29(22)38)28(37)33-16(2)18-6-9-20(31)10-7-18/h4-14,16,27,32,36H,1-3H3,(H,33,37)(H,34,38)(H,35,39)	XSBCFLGDNDHVIP-UHFFFAOYSA-N	79879	US20250388567, Compound 15	G protein-coupled receptor kinase 5	Homo sapiens		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79879&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			4360235	252656523							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124020	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)[C@H](O)c1ccco1	InChI=1S/C30H27FN4O5/c1-15-24(32-17(3)26(15)35-30(39)27(36)25-5-4-12-40-25)14-22-21-13-19(8-11-23(21)34-29(22)38)28(37)33-16(2)18-6-9-20(31)10-7-18/h4-14,16,27,32,36H,1-3H3,(H,33,37)(H,34,38)(H,35,39)	XSBCFLGDNDHVIP-UHFFFAOYSA-N	79879	US20250388567, Compound 15	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79879&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			4360235	252656523							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124021	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@@H]1CCc2ccccc21	InChI=1S/C34H32N4O3/c1-19-30(35-21(3)31(19)34(41)38-28-15-13-23-11-7-8-12-25(23)28)18-27-26-17-24(14-16-29(26)37-33(27)40)32(39)36-20(2)22-9-5-4-6-10-22/h4-12,14,16-18,20,28,35H,13,15H2,1-3H3,(H,36,39)(H,37,40)(H,38,41)	VJWNOVKQXOQUAG-UHFFFAOYSA-N	79880	US20250388567, Compound 16	G protein-coupled receptor kinase 5	Homo sapiens		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79880&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			3555442	252656524							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124022	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@@H]1CCc2ccccc21	InChI=1S/C34H32N4O3/c1-19-30(35-21(3)31(19)34(41)38-28-15-13-23-11-7-8-12-25(23)28)18-27-26-17-24(14-16-29(26)37-33(27)40)32(39)36-20(2)22-9-5-4-6-10-22/h4-12,14,16-18,20,28,35H,13,15H2,1-3H3,(H,36,39)(H,37,40)(H,38,41)	VJWNOVKQXOQUAG-UHFFFAOYSA-N	79880	US20250388567, Compound 16	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79880&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			3555442	252656524							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124023	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1CCc2ccccc21	InChI=1S/C34H32N4O3/c1-19-30(35-21(3)31(19)34(41)38-28-15-13-23-11-7-8-12-25(23)28)18-27-26-17-24(14-16-29(26)37-33(27)40)32(39)36-20(2)22-9-5-4-6-10-22/h4-12,14,16-18,20,28,35H,13,15H2,1-3H3,(H,36,39)(H,37,40)(H,38,41)	VJWNOVKQXOQUAG-UHFFFAOYSA-N	79881	US20250388567, Compound 17	G protein-coupled receptor kinase 5	Homo sapiens		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79881&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			1504905	252656525							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124024	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1CCc2ccccc21	InChI=1S/C34H32N4O3/c1-19-30(35-21(3)31(19)34(41)38-28-15-13-23-11-7-8-12-25(23)28)18-27-26-17-24(14-16-29(26)37-33(27)40)32(39)36-20(2)22-9-5-4-6-10-22/h4-12,14,16-18,20,28,35H,13,15H2,1-3H3,(H,36,39)(H,37,40)(H,38,41)	VJWNOVKQXOQUAG-UHFFFAOYSA-N	79881	US20250388567, Compound 17	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79881&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			1504905	252656525							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124025	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(O)C#N	InChI=1S/C26H24N4O3/c1-14-22(28-16(3)24(14)23(31)13-27)12-20-19-11-18(9-10-21(19)30-26(20)33)25(32)29-15(2)17-7-5-4-6-8-17/h4-12,15,23,28,31H,1-3H3,(H,29,32)(H,30,33)	FZABWBNTZZNJOC-UHFFFAOYSA-N	79882	US20250388567, Compound 18	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79882&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			16195424	252656526							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124026	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(O)C#N	InChI=1S/C26H24N4O3/c1-14-22(28-16(3)24(14)23(31)13-27)12-20-19-11-18(9-10-21(19)30-26(20)33)25(32)29-15(2)17-7-5-4-6-8-17/h4-12,15,23,28,31H,1-3H3,(H,29,32)(H,30,33)	FZABWBNTZZNJOC-UHFFFAOYSA-N	79882	US20250388567, Compound 18	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79882&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			16195424	252656526							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124027	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1C(=O)N[C@@H]1c2ccccc2C[C@H]1O	InChI=1S/C34H31FN4O4/c1-17-28(36-19(3)30(17)34(43)39-31-24-7-5-4-6-21(24)15-29(31)40)16-26-25-14-22(10-13-27(25)38-33(26)42)32(41)37-18(2)20-8-11-23(35)12-9-20/h4-14,16,18,29,31,36,40H,15H2,1-3H3,(H,37,41)(H,38,42)(H,39,43)	TYPFKPRVDKNUTC-UHFFFAOYSA-N	79884	US20250388567, Compound 19	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79884&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			2866993	252656528							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124028	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1C(=O)N[C@@H]1c2ccccc2C[C@H]1O	InChI=1S/C34H31FN4O4/c1-17-28(36-19(3)30(17)34(43)39-31-24-7-5-4-6-21(24)15-29(31)40)16-26-25-14-22(10-13-27(25)38-33(26)42)32(41)37-18(2)20-8-11-23(35)12-9-20/h4-14,16,18,29,31,36,40H,15H2,1-3H3,(H,37,41)(H,38,42)(H,39,43)	TYPFKPRVDKNUTC-UHFFFAOYSA-N	79884	US20250388567, Compound 19	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79884&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			2866993	252656528							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124029	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1C(=O)Cc2ccccc21	InChI=1S/C34H30N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,31,35H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	OBURIUNIYSHSKS-UHFFFAOYSA-N	79885	US20250388567, Compound 20	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79885&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			1935506	252656529							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124030	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1C(=O)Cc2ccccc21	InChI=1S/C34H30N4O4/c1-18-28(35-20(3)30(18)34(42)38-31-24-12-8-7-11-22(24)16-29(31)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,31,35H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	OBURIUNIYSHSKS-UHFFFAOYSA-N	79885	US20250388567, Compound 20	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79885&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			1935506	252656529							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124031	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)c1ccoc1	InChI=1S/C29H25FN4O4/c1-15-25(31-17(3)26(15)34-28(36)20-10-11-38-14-20)13-23-22-12-19(6-9-24(22)33-29(23)37)27(35)32-16(2)18-4-7-21(30)8-5-18/h4-14,16,31H,1-3H3,(H,32,35)(H,33,37)(H,34,36)	HHICSWRYIIPUMK-UHFFFAOYSA-N	79886	US20250388567, Compound 21	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79886&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			3902315	252656530							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124032	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)c1ccoc1	InChI=1S/C29H25FN4O4/c1-15-25(31-17(3)26(15)34-28(36)20-10-11-38-14-20)13-23-22-12-19(6-9-24(22)33-29(23)37)27(35)32-16(2)18-4-7-21(30)8-5-18/h4-14,16,31H,1-3H3,(H,32,35)(H,33,37)(H,34,36)	HHICSWRYIIPUMK-UHFFFAOYSA-N	79886	US20250388567, Compound 21	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79886&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			3902315	252656530							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124033	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)C(O)c1ccoc1	InChI=1S/C30H27FN4O5/c1-15-25(32-17(3)26(15)35-30(39)27(36)20-10-11-40-14-20)13-23-22-12-19(6-9-24(22)34-29(23)38)28(37)33-16(2)18-4-7-21(31)8-5-18/h4-14,16,27,32,36H,1-3H3,(H,33,37)(H,34,38)(H,35,39)	OTVHPEOLMSGQLK-UHFFFAOYSA-N	79887	US20250388567, Compound 22	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79887&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			2527292	252656531							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124034	Cc1[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1NC(=O)C(O)c1ccoc1	InChI=1S/C30H27FN4O5/c1-15-25(32-17(3)26(15)35-30(39)27(36)20-10-11-40-14-20)13-23-22-12-19(6-9-24(22)34-29(23)38)28(37)33-16(2)18-4-7-21(31)8-5-18/h4-14,16,27,32,36H,1-3H3,(H,33,37)(H,34,38)(H,35,39)	OTVHPEOLMSGQLK-UHFFFAOYSA-N	79887	US20250388567, Compound 22	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79887&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			2527292	252656531							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124035	COCO[C@@H]1Cc2ccccc2[C@H]1NC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C	InChI=1S/C36H36N4O5/c1-20-30(37-22(3)32(20)36(43)40-33-26-13-9-8-12-24(26)17-31(33)45-19-44-4)18-28-27-16-25(14-15-29(27)39-35(28)42)34(41)38-21(2)23-10-6-5-7-11-23/h5-16,18,21,31,33,37H,17,19H2,1-4H3,(H,38,41)(H,39,42)(H,40,43)	JQBNWVFSSASYFG-UHFFFAOYSA-N	79888	US20250388567, Compound 23	G protein-coupled receptor kinase 5	Homo sapiens		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79888&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			16238272	252656532							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124036	COCO[C@@H]1Cc2ccccc2[C@H]1NC(=O)c1c(C)[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C	InChI=1S/C36H36N4O5/c1-20-30(37-22(3)32(20)36(43)40-33-26-13-9-8-12-24(26)17-31(33)45-19-44-4)18-28-27-16-25(14-15-29(27)39-35(28)42)34(41)38-21(2)23-10-6-5-7-11-23/h5-16,18,21,31,33,37H,17,19H2,1-4H3,(H,38,41)(H,39,42)(H,40,43)	JQBNWVFSSASYFG-UHFFFAOYSA-N	79888	US20250388567, Compound 23	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79888&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			16238272	252656532							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124037	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@@H]1c2ccccc2CC[C@@H]1O	InChI=1S/C35H34N4O4/c1-19-29(36-21(3)31(19)35(43)39-32-25-12-8-7-11-23(25)14-16-30(32)40)18-27-26-17-24(13-15-28(26)38-34(27)42)33(41)37-20(2)22-9-5-4-6-10-22/h4-13,15,17-18,20,30,32,36,40H,14,16H2,1-3H3,(H,37,41)(H,38,42)(H,39,43)	WXXRFDJWMCRHSP-UHFFFAOYSA-N	79889	US20250388567, Compound 24	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79889&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			2404639	252656533							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124038	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@@H]1c2ccccc2CC[C@@H]1O	InChI=1S/C35H34N4O4/c1-19-29(36-21(3)31(19)35(43)39-32-25-12-8-7-11-23(25)14-16-30(32)40)18-27-26-17-24(13-15-28(26)38-34(27)42)33(41)37-20(2)22-9-5-4-6-10-22/h4-13,15,17-18,20,30,32,36,40H,14,16H2,1-3H3,(H,37,41)(H,38,42)(H,39,43)	WXXRFDJWMCRHSP-UHFFFAOYSA-N	79889	US20250388567, Compound 24	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79889&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			2404639	252656533							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124039	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1c2ccccc2CC[C@H]1O	InChI=1S/C35H34N4O4/c1-19-29(36-21(3)31(19)35(43)39-32-25-12-8-7-11-23(25)14-16-30(32)40)18-27-26-17-24(13-15-28(26)38-34(27)42)33(41)37-20(2)22-9-5-4-6-10-22/h4-13,15,17-18,20,30,32,36,40H,14,16H2,1-3H3,(H,37,41)(H,38,42)(H,39,43)	WXXRFDJWMCRHSP-UHFFFAOYSA-N	79890	US20250388567, Compound 25	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79890&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			3923182	252656534							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124040	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1c2ccccc2CC[C@H]1O	InChI=1S/C35H34N4O4/c1-19-29(36-21(3)31(19)35(43)39-32-25-12-8-7-11-23(25)14-16-30(32)40)18-27-26-17-24(13-15-28(26)38-34(27)42)33(41)37-20(2)22-9-5-4-6-10-22/h4-13,15,17-18,20,30,32,36,40H,14,16H2,1-3H3,(H,37,41)(H,38,42)(H,39,43)	WXXRFDJWMCRHSP-UHFFFAOYSA-N	79890	US20250388567, Compound 25	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79890&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			3923182	252656534							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124041	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC1c2ccccc2OCC1O	InChI=1S/C34H32N4O5/c1-18-27(35-20(3)30(18)34(42)38-31-23-11-7-8-12-29(23)43-17-28(31)39)16-25-24-15-22(13-14-26(24)37-33(25)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-16,19,28,31,35,39H,17H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	HMWJCGRKOKYTBT-UHFFFAOYSA-N	79891	US20250388567, Compound 26	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79891&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			2999024	252656535							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124042	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC1c2ccccc2OCC1O	InChI=1S/C34H32N4O5/c1-18-27(35-20(3)30(18)34(42)38-31-23-11-7-8-12-29(23)43-17-28(31)39)16-25-24-15-22(13-14-26(24)37-33(25)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-16,19,28,31,35,39H,17H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	HMWJCGRKOKYTBT-UHFFFAOYSA-N	79891	US20250388567, Compound 26	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79891&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			2999024	252656535							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124043	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC(O)c1ccco1	InChI=1S/C31H30N4O5/c1-17-25(33-19(3)28(17)31(39)32-16-26(36)27-10-7-13-40-27)15-23-22-14-21(11-12-24(22)35-30(23)38)29(37)34-18(2)20-8-5-4-6-9-20/h4-15,18,26,33,36H,16H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)	JFGZMYFGTOFVCD-UHFFFAOYSA-N	79892	US20250388567, Compound 27	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79892&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			663049	252656536							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124044	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC(O)c1ccco1	InChI=1S/C31H30N4O5/c1-17-25(33-19(3)28(17)31(39)32-16-26(36)27-10-7-13-40-27)15-23-22-14-21(11-12-24(22)35-30(23)38)29(37)34-18(2)20-8-5-4-6-9-20/h4-15,18,26,33,36H,16H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)	JFGZMYFGTOFVCD-UHFFFAOYSA-N	79892	US20250388567, Compound 27	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79892&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			663049	252656536							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124045	COc1cccc(C(O)C(=O)Nc2c(C)[nH]c(/C=C3\C(=O)Nc4ccc(C(=O)N[C@H](C)c5ccc(F)cc5)cc43)c2C)c1	InChI=1S/C33H31FN4O5/c1-17-28(35-19(3)29(17)38-33(42)30(39)21-6-5-7-24(14-21)43-4)16-26-25-15-22(10-13-27(25)37-32(26)41)31(40)36-18(2)20-8-11-23(34)12-9-20/h5-16,18,30,35,39H,1-4H3,(H,36,40)(H,37,41)(H,38,42)	YVAJIWAKFYDIPD-UHFFFAOYSA-N	79893	US20250388567, Compound 28	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79893&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			2003091	252656537							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124046	COc1cccc(C(O)C(=O)Nc2c(C)[nH]c(/C=C3\C(=O)Nc4ccc(C(=O)N[C@H](C)c5ccc(F)cc5)cc43)c2C)c1	InChI=1S/C33H31FN4O5/c1-17-28(35-19(3)29(17)38-33(42)30(39)21-6-5-7-24(14-21)43-4)16-26-25-15-22(10-13-27(25)37-32(26)41)31(40)36-18(2)20-8-11-23(34)12-9-20/h5-16,18,30,35,39H,1-4H3,(H,36,40)(H,37,41)(H,38,42)	YVAJIWAKFYDIPD-UHFFFAOYSA-N	79893	US20250388567, Compound 28	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79893&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			2003091	252656537							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124047	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCc1ccco1	InChI=1S/C30H28N4O4/c1-17-26(32-19(3)27(17)30(37)31-16-22-10-7-13-38-22)15-24-23-14-21(11-12-25(23)34-29(24)36)28(35)33-18(2)20-8-5-4-6-9-20/h4-15,18,32H,16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	OWWAIBNZLWTCDN-UHFFFAOYSA-N	79894	US20250388567, Compound 29	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79894&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			1855624	252656538							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124048	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCc1ccco1	InChI=1S/C30H28N4O4/c1-17-26(32-19(3)27(17)30(37)31-16-22-10-7-13-38-22)15-24-23-14-21(11-12-25(23)34-29(24)36)28(35)33-18(2)20-8-5-4-6-9-20/h4-15,18,32H,16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	OWWAIBNZLWTCDN-UHFFFAOYSA-N	79894	US20250388567, Compound 29	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79894&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			1855624	252656538							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124049	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC1CCCO1	InChI=1S/C30H32N4O4/c1-17-26(32-19(3)27(17)30(37)31-16-22-10-7-13-38-22)15-24-23-14-21(11-12-25(23)34-29(24)36)28(35)33-18(2)20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22,32H,7,10,13,16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	WKRZFYOFMLFLNQ-UHFFFAOYSA-N	79895	US20250388567, Compound 30	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79895&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			2212701	252656539							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124050	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC1CCCO1	InChI=1S/C30H32N4O4/c1-17-26(32-19(3)27(17)30(37)31-16-22-10-7-13-38-22)15-24-23-14-21(11-12-25(23)34-29(24)36)28(35)33-18(2)20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22,32H,7,10,13,16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	WKRZFYOFMLFLNQ-UHFFFAOYSA-N	79895	US20250388567, Compound 30	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79895&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			2212701	252656539							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124051	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC(C)c1ccco1	InChI=1S/C31H30N4O4/c1-17-26(32-20(4)28(17)31(38)34-19(3)27-11-8-14-39-27)16-24-23-15-22(12-13-25(23)35-30(24)37)29(36)33-18(2)21-9-6-5-7-10-21/h5-16,18-19,32H,1-4H3,(H,33,36)(H,34,38)(H,35,37)	BAWYNMOMINTTFZ-UHFFFAOYSA-N	79896	US20250388567, Compound 31	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79896&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			6869836	252656540							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124052	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC(C)c1ccco1	InChI=1S/C31H30N4O4/c1-17-26(32-20(4)28(17)31(38)34-19(3)27-11-8-14-39-27)16-24-23-15-22(12-13-25(23)35-30(24)37)29(36)33-18(2)21-9-6-5-7-10-21/h5-16,18-19,32H,1-4H3,(H,33,36)(H,34,38)(H,35,37)	BAWYNMOMINTTFZ-UHFFFAOYSA-N	79896	US20250388567, Compound 31	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79896&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			6869836	252656540							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124053	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC(O)c1ccoc1	InChI=1S/C31H30N4O5/c1-17-26(33-19(3)28(17)31(39)32-15-27(36)22-11-12-40-16-22)14-24-23-13-21(9-10-25(23)35-30(24)38)29(37)34-18(2)20-7-5-4-6-8-20/h4-14,16,18,27,33,36H,15H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)	GOGMPSPFHORWNL-UHFFFAOYSA-N	79898	US20250388567, Compound 32	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79898&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			2813734	252656542							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124054	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC(O)c1ccoc1	InChI=1S/C31H30N4O5/c1-17-26(33-19(3)28(17)31(39)32-15-27(36)22-11-12-40-16-22)14-24-23-13-21(9-10-25(23)35-30(24)38)29(37)34-18(2)20-7-5-4-6-8-20/h4-14,16,18,27,33,36H,15H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)	GOGMPSPFHORWNL-UHFFFAOYSA-N	79898	US20250388567, Compound 32	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79898&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			2813734	252656542							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124055	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)Nc1nc2ccccc2[nH]1	InChI=1S/C32H28N6O3/c1-17-27(33-19(3)28(17)31(41)38-32-36-25-11-7-8-12-26(25)37-32)16-23-22-15-21(13-14-24(22)35-30(23)40)29(39)34-18(2)20-9-5-4-6-10-20/h4-16,18,33H,1-3H3,(H,34,39)(H,35,40)(H2,36,37,38,41)	ILBIGBDMZYUHPI-UHFFFAOYSA-N	79899	US20250388567, Compound 33	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79899&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			16060398	252656543							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124056	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)Nc1nc2ccccc2[nH]1	InChI=1S/C32H28N6O3/c1-17-27(33-19(3)28(17)31(41)38-32-36-25-11-7-8-12-26(25)37-32)16-23-22-15-21(13-14-24(22)35-30(23)40)29(39)34-18(2)20-9-5-4-6-10-20/h4-16,18,33H,1-3H3,(H,34,39)(H,35,40)(H2,36,37,38,41)	ILBIGBDMZYUHPI-UHFFFAOYSA-N	79899	US20250388567, Compound 33	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79899&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			16060398	252656543							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124057	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1Cc2ccccc2[C@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-29-16-22-11-7-8-12-24(22)31(29)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	JHALMAMCSXKIHT-UHFFFAOYSA-N	79900	US20250388567, Compound 34	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79900&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			2931287	252656544							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124058	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)N[C@H]1Cc2ccccc2[C@H]1O	InChI=1S/C34H32N4O4/c1-18-28(35-20(3)30(18)34(42)38-29-16-22-11-7-8-12-24(22)31(29)39)17-26-25-15-23(13-14-27(25)37-33(26)41)32(40)36-19(2)21-9-5-4-6-10-21/h4-15,17,19,29,31,35,39H,16H2,1-3H3,(H,36,40)(H,37,41)(H,38,42)	JHALMAMCSXKIHT-UHFFFAOYSA-N	79900	US20250388567, Compound 34	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79900&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			2931287	252656544							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124059	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1C(=O)NCC1CCCO1	InChI=1S/C30H31FN4O4/c1-16-26(33-18(3)27(16)30(38)32-15-22-5-4-12-39-22)14-24-23-13-20(8-11-25(23)35-29(24)37)28(36)34-17(2)19-6-9-21(31)10-7-19/h6-11,13-14,17,22,33H,4-5,12,15H2,1-3H3,(H,32,38)(H,34,36)(H,35,37)	DLXQVKTWEDKTOG-UHFFFAOYSA-N	79903	US20250388567, Compound 35	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79903&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			210787	252656547							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124060	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccc(F)cc4)cc32)c(C)c1C(=O)NCC1CCCO1	InChI=1S/C30H31FN4O4/c1-16-26(33-18(3)27(16)30(38)32-15-22-5-4-12-39-22)14-24-23-13-20(8-11-25(23)35-29(24)37)28(36)34-17(2)19-6-9-21(31)10-7-19/h6-11,13-14,17,22,33H,4-5,12,15H2,1-3H3,(H,32,38)(H,34,36)(H,35,37)	DLXQVKTWEDKTOG-UHFFFAOYSA-N	79903	US20250388567, Compound 35	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79903&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			210787	252656547							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124061	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC[C@H]1CCCO1	InChI=1S/C30H32N4O4/c1-17-26(32-19(3)27(17)30(37)31-16-22-10-7-13-38-22)15-24-23-14-21(11-12-25(23)34-29(24)36)28(35)33-18(2)20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22,32H,7,10,13,16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	WKRZFYOFMLFLNQ-UHFFFAOYSA-N	79906	US20250388567, Compound 36	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79906&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			3141919	252656550							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124062	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC[C@H]1CCCO1	InChI=1S/C30H32N4O4/c1-17-26(32-19(3)27(17)30(37)31-16-22-10-7-13-38-22)15-24-23-14-21(11-12-25(23)34-29(24)36)28(35)33-18(2)20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22,32H,7,10,13,16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	WKRZFYOFMLFLNQ-UHFFFAOYSA-N	79906	US20250388567, Compound 36	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79906&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			3141919	252656550							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124063	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC[C@@H]1CCCO1	InChI=1S/C30H32N4O4/c1-17-26(32-19(3)27(17)30(37)31-16-22-10-7-13-38-22)15-24-23-14-21(11-12-25(23)34-29(24)36)28(35)33-18(2)20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22,32H,7,10,13,16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	WKRZFYOFMLFLNQ-UHFFFAOYSA-N	79907	US20250388567, Compound 37	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79907&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			1093851	252656551							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124064	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC[C@@H]1CCCO1	InChI=1S/C30H32N4O4/c1-17-26(32-19(3)27(17)30(37)31-16-22-10-7-13-38-22)15-24-23-14-21(11-12-25(23)34-29(24)36)28(35)33-18(2)20-8-5-4-6-9-20/h4-6,8-9,11-12,14-15,18,22,32H,7,10,13,16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	WKRZFYOFMLFLNQ-UHFFFAOYSA-N	79907	US20250388567, Compound 37	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79907&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			1093851	252656551							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124065	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC1CCCCO1	InChI=1S/C31H34N4O4/c1-18-27(33-20(3)28(18)31(38)32-17-23-11-7-8-14-39-23)16-25-24-15-22(12-13-26(24)35-30(25)37)29(36)34-19(2)21-9-5-4-6-10-21/h4-6,9-10,12-13,15-16,19,23,33H,7-8,11,14,17H2,1-3H3,(H,32,38)(H,34,36)(H,35,37)	QHHUSXFQGJHRKC-UHFFFAOYSA-N	79908	US20250388567, Compound 38	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79908&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			627227	252656552							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124066	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC1CCCCO1	InChI=1S/C31H34N4O4/c1-18-27(33-20(3)28(18)31(38)32-17-23-11-7-8-14-39-23)16-25-24-15-22(12-13-26(24)35-30(25)37)29(36)34-19(2)21-9-5-4-6-10-21/h4-6,9-10,12-13,15-16,19,23,33H,7-8,11,14,17H2,1-3H3,(H,32,38)(H,34,36)(H,35,37)	QHHUSXFQGJHRKC-UHFFFAOYSA-N	79908	US20250388567, Compound 38	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79908&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			627227	252656552							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124067	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC1CCOC1	InChI=1S/C29H30N4O4/c1-16-25(30-18(3)26(16)29(36)32-21-11-12-37-15-21)14-23-22-13-20(9-10-24(22)33-28(23)35)27(34)31-17(2)19-7-5-4-6-8-19/h4-10,13-14,17,21,30H,11-12,15H2,1-3H3,(H,31,34)(H,32,36)(H,33,35)	DSZLZRMLMCYRHW-UHFFFAOYSA-N	79910	US20250388567, Compound 39	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79910&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			24746898	252656554							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124068	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC1CCOC1	InChI=1S/C29H30N4O4/c1-16-25(30-18(3)26(16)29(36)32-21-11-12-37-15-21)14-23-22-13-20(9-10-24(22)33-28(23)35)27(34)31-17(2)19-7-5-4-6-8-19/h4-10,13-14,17,21,30H,11-12,15H2,1-3H3,(H,31,34)(H,32,36)(H,33,35)	DSZLZRMLMCYRHW-UHFFFAOYSA-N	79910	US20250388567, Compound 39	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79910&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			24746898	252656554							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124069	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC1CCOC1	InChI=1S/C30H32N4O4/c1-17-26(32-19(3)27(17)30(37)31-15-20-11-12-38-16-20)14-24-23-13-22(9-10-25(23)34-29(24)36)28(35)33-18(2)21-7-5-4-6-8-21/h4-10,13-14,18,20,32H,11-12,15-16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	WLQOJMOBCBNABX-UHFFFAOYSA-N	79912	US20250388567, Compound 40	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79912&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			24747377	252656556							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124070	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC1CCOC1	InChI=1S/C30H32N4O4/c1-17-26(32-19(3)27(17)30(37)31-15-20-11-12-38-16-20)14-24-23-13-22(9-10-25(23)34-29(24)36)28(35)33-18(2)21-7-5-4-6-8-21/h4-10,13-14,18,20,32H,11-12,15-16H2,1-3H3,(H,31,37)(H,33,35)(H,34,36)	WLQOJMOBCBNABX-UHFFFAOYSA-N	79912	US20250388567, Compound 40	Beta-adrenergic receptor kinase 1	Bos taurus		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79912&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			24747377	252656556							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124071	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC1CC(=O)c2ccccc2O1	InChI=1S/C35H32N4O5/c1-19-29(37-21(3)32(19)35(43)36-18-24-16-30(40)25-11-7-8-12-31(25)44-24)17-27-26-15-23(13-14-28(26)39-34(27)42)33(41)38-20(2)22-9-5-4-6-10-22/h4-15,17,20,24,37H,16,18H2,1-3H3,(H,36,43)(H,38,41)(H,39,42)	FNDOBFNOGHEDSY-UHFFFAOYSA-N	79913	US20250388567, Compound 41	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79913&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			24747492	252656557							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124072	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC1CC(=O)c2ccccc2O1	InChI=1S/C35H32N4O5/c1-19-29(37-21(3)32(19)35(43)36-18-24-16-30(40)25-11-7-8-12-31(25)44-24)17-27-26-15-23(13-14-28(26)39-34(27)42)33(41)38-20(2)22-9-5-4-6-10-22/h4-15,17,20,24,37H,16,18H2,1-3H3,(H,36,43)(H,38,41)(H,39,42)	FNDOBFNOGHEDSY-UHFFFAOYSA-N	79913	US20250388567, Compound 41	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79913&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			24747492	252656557							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124073	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC1CCS(=O)(=O)CC1	InChI=1S/C30H32N4O5S/c1-17-26(31-19(3)27(17)30(37)33-22-11-13-40(38,39)14-12-22)16-24-23-15-21(9-10-25(23)34-29(24)36)28(35)32-18(2)20-7-5-4-6-8-20/h4-10,15-16,18,22,31H,11-14H2,1-3H3,(H,32,35)(H,33,37)(H,34,36)	ARUNWDVBAQYBEL-UHFFFAOYSA-N	79915	US20250388567, Compound 42	G protein-coupled receptor kinase 5	Homo sapiens		 550							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79915&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			7097319	252656559							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124074	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC1CCS(=O)(=O)CC1	InChI=1S/C30H32N4O5S/c1-17-26(31-19(3)27(17)30(37)33-22-11-13-40(38,39)14-12-22)16-24-23-15-21(9-10-25(23)34-29(24)36)28(35)32-18(2)20-7-5-4-6-8-20/h4-10,15-16,18,22,31H,11-14H2,1-3H3,(H,32,35)(H,33,37)(H,34,36)	ARUNWDVBAQYBEL-UHFFFAOYSA-N	79915	US20250388567, Compound 42	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79915&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			7097319	252656559							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124075	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC1CCOCC1	InChI=1S/C30H32N4O4/c1-17-26(31-19(3)27(17)30(37)33-22-11-13-38-14-12-22)16-24-23-15-21(9-10-25(23)34-29(24)36)28(35)32-18(2)20-7-5-4-6-8-20/h4-10,15-16,18,22,31H,11-14H2,1-3H3,(H,32,35)(H,33,37)(H,34,36)	LPZUFYYXFKCANY-UHFFFAOYSA-N	79916	US20250388567, Compound 43	G protein-coupled receptor kinase 5	Homo sapiens		 5500							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79916&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			16456743	252656560							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124076	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NC1CCOCC1	InChI=1S/C30H32N4O4/c1-17-26(31-19(3)27(17)30(37)33-22-11-13-38-14-12-22)16-24-23-15-21(9-10-25(23)34-29(24)36)28(35)32-18(2)20-7-5-4-6-8-20/h4-10,15-16,18,22,31H,11-14H2,1-3H3,(H,32,35)(H,33,37)(H,34,36)	LPZUFYYXFKCANY-UHFFFAOYSA-N	79916	US20250388567, Compound 43	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79916&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			16456743	252656560							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																			
124077	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC(O)C1CCOC1	InChI=1S/C31H34N4O5/c1-17-26(33-19(3)28(17)31(39)32-15-27(36)22-11-12-40-16-22)14-24-23-13-21(9-10-25(23)35-30(24)38)29(37)34-18(2)20-7-5-4-6-8-20/h4-10,13-14,18,22,27,33,36H,11-12,15-16H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)	IPLJETJUFOYRIU-UHFFFAOYSA-N	79917	US20250388567, Compound 44	G protein-coupled receptor kinase 5	Homo sapiens		<100							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004461&target=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79917&enzyme=G+protein-coupled+receptor+kinase+5&column=ki&startPg=0&Increment=50&submit=Search			729709	252656561							1	MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQPIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQVGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS	9CKO	G protein-coupled receptor kinase 5	GRK5_HUMAN	P34947	D3DRD0 Q5T059																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124078	Cc1[nH]c(/C=C2C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c(C)c1C(=O)NCC(O)C1CCOC1	InChI=1S/C31H34N4O5/c1-17-26(33-19(3)28(17)31(39)32-15-27(36)22-11-12-40-16-22)14-24-23-13-21(9-10-25(23)35-30(24)38)29(37)34-18(2)20-7-5-4-6-8-20/h4-10,13-14,18,22,27,33,36H,11-12,15-16H2,1-3H3,(H,32,39)(H,34,37)(H,35,38)	IPLJETJUFOYRIU-UHFFFAOYSA-N	79917	US20250388567, Compound 44	Beta-adrenergic receptor kinase 1	Bos taurus		>10000							US Patent		10.7270/Q2R49WJ5			US20250388567	GHOSH, AK; Tesmer, J; Sonawane, A; Manda, R	12/25/2025	5/6/2026	Purdue Research Foundation	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=79917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50007158&target=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=79917&enzyme=Beta-adrenergic+receptor+kinase+1&column=ki&startPg=0&Increment=50&submit=Search			729709	252656561							1	MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLACSHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRSPVVELSKVPLIQRGSANGL	5HE3	Beta-adrenergic receptor kinase 1	ARBK1_BOVIN	P21146