BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
124228	COc1cnc(C)c(-n2c(N)c(C(N)=O)c3cc(Cl)cnc32)c1C	InChI=1S/C16H16ClN5O2/c1-7-11(24-3)6-20-8(2)13(7)22-14(18)12(15(19)23)10-4-9(17)5-21-16(10)22/h4-6H,18H2,1-3H3,(H2,19,23)	SKWAGJCSCNWSKC-UHFFFAOYSA-N	81845	US20250388583, Compound 542	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81845&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			23626728	131342419							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124229	COc1cnc(C)c(-n2c(N)c(C(N)=O)c3cc(Cl)cnc32)c1C	InChI=1S/C16H16ClN5O2/c1-7-11(24-3)6-20-8(2)13(7)22-14(18)12(15(19)23)10-4-9(17)5-21-16(10)22/h4-6H,18H2,1-3H3,(H2,19,23)	SKWAGJCSCNWSKC-UHFFFAOYSA-N	81845	US20250388583, Compound 542	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81845&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			23626728	131342419							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124230	Cc1ncc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc(Cl)cnc21	InChI=1S/C15H14ClN5O2/c1-6-10(22)5-19-7(2)12(6)21-13(17)11(14(18)23)9-3-8(16)4-20-15(9)21/h3-5,22H,17H2,1-2H3,(H2,18,23)	IOVRGFLYMIQZAO-UHFFFAOYSA-N	83296	US20250388583, Compound 543	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83296&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			851992	252658493							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124231	Cc1ncc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc(Cl)cnc21	InChI=1S/C15H14ClN5O2/c1-6-10(22)5-19-7(2)12(6)21-13(17)11(14(18)23)9-3-8(16)4-20-15(9)21/h3-5,22H,17H2,1-2H3,(H2,18,23)	IOVRGFLYMIQZAO-UHFFFAOYSA-N	83296	US20250388583, Compound 543	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83296	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83296&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			851992	252658493							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124232	Cc1cc2ccoc2c(C)c1-n1c(N)c(C(N)=O)c2cc(Cl)cnc21	InChI=1S/C18H15ClN4O2/c1-8-5-10-3-4-25-15(10)9(2)14(8)23-16(20)13(17(21)24)12-6-11(19)7-22-18(12)23/h3-7H,20H2,1-2H3,(H2,21,24)	AWLAMAFRHBYBIB-UHFFFAOYSA-N	83297	US20250388583, Compound 544	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83297&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			1177949	252658494							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124233	Cc1cc2ccoc2c(C)c1-n1c(N)c(C(N)=O)c2cc(Cl)cnc21	InChI=1S/C18H15ClN4O2/c1-8-5-10-3-4-25-15(10)9(2)14(8)23-16(20)13(17(21)24)12-6-11(19)7-22-18(12)23/h3-7H,20H2,1-2H3,(H2,21,24)	AWLAMAFRHBYBIB-UHFFFAOYSA-N	83297	US20250388583, Compound 544	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83297	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83297&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			1177949	252658494							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124234	Cc1cc2c(c(C)c1-n1c(N)c(C(N)=O)c3cc(Cl)cnc31)OCO2	InChI=1S/C17H15ClN4O3/c1-7-3-11-14(25-6-24-11)8(2)13(7)22-15(19)12(16(20)23)10-4-9(18)5-21-17(10)22/h3-5H,6,19H2,1-2H3,(H2,20,23)	YQUPOLDFERCTAA-UHFFFAOYSA-N	83298	US20250388583, Compound 546	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83298	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83298&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2946860	252658495							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124235	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cncnc21	InChI=1S/C15H15N5O2/c1-7-3-4-10(21)8(2)12(7)20-13(16)11(14(17)22)9-5-18-6-19-15(9)20/h3-6,21H,16H2,1-2H3,(H2,17,22)	AWGYUGPQPNQOOH-UHFFFAOYSA-N	83299	US20250388583, Compound 547	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83299&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4247296	252658496							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124236	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cncnc21	InChI=1S/C15H15N5O2/c1-7-3-4-10(21)8(2)12(7)20-13(16)11(14(17)22)9-5-18-6-19-15(9)20/h3-6,21H,16H2,1-2H3,(H2,17,22)	AWGYUGPQPNQOOH-UHFFFAOYSA-N	83299	US20250388583, Compound 547	Tyrosine-protein kinase Lck	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83299	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83299&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4247296	252658496							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124237	Cc1ccc(O)c(C)c1-c1c(N)c(C(N)=O)c2nccc(C)n12	InChI=1S/C17H18N4O2/c1-8-4-5-11(22)10(3)12(8)15-14(18)13(16(19)23)17-20-7-6-9(2)21(15)17/h4-7,22H,18H2,1-3H3,(H2,19,23)	XDOHFPCESQTGNW-UHFFFAOYSA-N	83300	US20250388583, Compound 548	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83300	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83300&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			9551332	252658497							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124238	Cc1ccn2c(-c3c(C)ccc(O)c3C)c(N)c(C(N)=O)c2n1	InChI=1S/C17H18N4O2/c1-8-4-5-11(22)10(3)12(8)15-14(18)13(16(19)23)17-20-9(2)6-7-21(15)17/h4-7,22H,18H2,1-3H3,(H2,19,23)	ZWGCXLUMWOQHKW-UHFFFAOYSA-N	83301	US20250388583, Compound 550	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83301	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83301&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2953765	252658498							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124239	Cc1ccn2c(-c3c(C)ccc(O)c3C)c(N)c(C(N)=O)c2c1	InChI=1S/C18H19N3O2/c1-9-6-7-21-12(8-9)15(18(20)23)16(19)17(21)14-10(2)4-5-13(22)11(14)3/h4-8,22H,19H2,1-3H3,(H2,20,23)	PTGNVIHZGXATTA-UHFFFAOYSA-N	83302	US20250388583, Compound 552	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83302	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83302&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			3730844	252658499							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124240	Cc1cnc2c(c1)c(C(N)=O)c(N)n2-c1c(C)ccc2ocnc12	InChI=1S/C17H15N5O2/c1-8-5-10-12(16(19)23)15(18)22(17(10)20-6-8)14-9(2)3-4-11-13(14)21-7-24-11/h3-7H,18H2,1-2H3,(H2,19,23)	PNWGQALDJCYGOM-UHFFFAOYSA-N	83303	US20250388583, Compound 553	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83303	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83303&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5783449	252658500							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124241	Cc1cn2c(C(N)=O)c(N)c(-c3c(C)ccc(O)c3C)c2cn1	InChI=1S/C17H18N4O2/c1-8-4-5-12(22)10(3)13(8)14-11-6-20-9(2)7-21(11)16(15(14)18)17(19)23/h4-7,22H,18H2,1-3H3,(H2,19,23)	NXHPNVTXXHDONL-UHFFFAOYSA-N	83305	US20250388583, Compound 555	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83305	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83305&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2318144	252658502							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124242	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cnc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-12(15(19)23)14(18)22(16(11)21-10(7)4)13-8(2)6-20-17(24)9(13)3/h5-6H,18H2,1-4H3,(H2,19,23)(H,20,24)	CAIUVIVSRIPODB-UHFFFAOYSA-N	83306	US20250388583, Compound 556::US20260001879, Compound 177	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83306&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4330067	252658503							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124243	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cnc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-12(15(19)23)14(18)22(16(11)21-10(7)4)13-8(2)6-20-17(24)9(13)3/h5-6H,18H2,1-4H3,(H2,19,23)(H,20,24)	CAIUVIVSRIPODB-UHFFFAOYSA-N	83306	US20250388583, Compound 556::US20260001879, Compound 177	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83306	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83306&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4330067	252658503							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124244	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(NCCO)nc21	InChI=1S/C17H20N6O3/c1-8-3-4-11(25)9(2)13(8)23-14(18)12(15(19)26)10-7-21-17(20-5-6-24)22-16(10)23/h3-4,7,24-25H,5-6,18H2,1-2H3,(H2,19,26)(H,20,21,22)	OLLDAFXLQJARTF-UHFFFAOYSA-N	83307	US20250388583, Compound 559	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83307&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4882500	252658504							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124245	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(NCCO)nc21	InChI=1S/C17H20N6O3/c1-8-3-4-11(25)9(2)13(8)23-14(18)12(15(19)26)10-7-21-17(20-5-6-24)22-16(10)23/h3-4,7,24-25H,5-6,18H2,1-2H3,(H2,19,26)(H,20,21,22)	OLLDAFXLQJARTF-UHFFFAOYSA-N	83307	US20250388583, Compound 559	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83307	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83307&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4882500	252658504							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124246	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ncc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-13(16(19)24)15(18)22(17(11)21-9(7)3)14-8(2)12(23)6-20-10(14)4/h5-6,23H,18H2,1-4H3,(H2,19,24)	FOMLLEZHJXWJOG-UHFFFAOYSA-N	83308	US20250388583, Compound 560	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83308&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			91898501	252658505							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124247	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ncc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-13(16(19)24)15(18)22(17(11)21-9(7)3)14-8(2)12(23)6-20-10(14)4/h5-6,23H,18H2,1-4H3,(H2,19,24)	FOMLLEZHJXWJOG-UHFFFAOYSA-N	83308	US20250388583, Compound 560	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83308	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83308&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			91898501	252658505							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124248	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ncc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-13(16(19)24)15(18)22(17(11)21-9(7)3)14-8(2)12(23)6-20-10(14)4/h5-6,23H,18H2,1-4H3,(H2,19,24)	FOMLLEZHJXWJOG-UHFFFAOYSA-N	83309	US20250388583, Compound 561	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83309&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5049256	252658506							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124249	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ncc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-13(16(19)24)15(18)22(17(11)21-9(7)3)14-8(2)12(23)6-20-10(14)4/h5-6,23H,18H2,1-4H3,(H2,19,24)	FOMLLEZHJXWJOG-UHFFFAOYSA-N	83309	US20250388583, Compound 561	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83309	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83309&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			5049256	252658506							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124250	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCC3	InChI=1S/C19H19FN4O2/c1-8-12(20)7-14(25)9(2)16(8)24-17(21)15(18(22)26)11-6-10-4-3-5-13(10)23-19(11)24/h6-7,25H,3-5,21H2,1-2H3,(H2,22,26)	IJEVIYZZAGBNOM-UHFFFAOYSA-N	83310	US20250388583, Compound 565::US20260001879, Compound 201	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83310&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			91898502	252658507							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124251	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCC3	InChI=1S/C19H19FN4O2/c1-8-12(20)7-14(25)9(2)16(8)24-17(21)15(18(22)26)11-6-10-4-3-5-13(10)23-19(11)24/h6-7,25H,3-5,21H2,1-2H3,(H2,22,26)	IJEVIYZZAGBNOM-UHFFFAOYSA-N	83310	US20250388583, Compound 565::US20260001879, Compound 201	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83310	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83310&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			91898502	252658507							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124252	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ncc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-13(16(19)24)15(18)22(17(11)21-9(7)3)14-8(2)12(23)6-20-10(14)4/h5-6,23H,18H2,1-4H3,(H2,19,24)	FOMLLEZHJXWJOG-UHFFFAOYSA-N	83311	US20250388583, Compound 566::US20260001879, Compound 176	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83311&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4305845	252658508							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124253	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ncc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-13(16(19)24)15(18)22(17(11)21-9(7)3)14-8(2)12(23)6-20-10(14)4/h5-6,23H,18H2,1-4H3,(H2,19,24)	FOMLLEZHJXWJOG-UHFFFAOYSA-N	83311	US20250388583, Compound 566::US20260001879, Compound 176	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83311	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83311&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4305845	252658508							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124254	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ncc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-13(16(19)24)15(18)22(17(11)21-9(7)3)14-8(2)12(23)6-20-10(14)4/h5-6,23H,18H2,1-4H3,(H2,19,24)	FOMLLEZHJXWJOG-UHFFFAOYSA-N	83312	US20250388583, Compound 567	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83312&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2870045	252658509							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124255	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)OCCN3C	InChI=1S/C19H21N5O3/c1-9-4-5-13(25)10(2)15(9)24-16(20)14(17(21)26)11-8-12-19(22-18(11)24)27-7-6-23(12)3/h4-5,8,25H,6-7,20H2,1-3H3,(H2,21,26)	BUHFVPHFBIUYFT-UHFFFAOYSA-N	83313	7-amino-6-(3-hydroxy-2,6-dimethylphenyl)-1-methyl-1,2,3,6-tetrahydropyrrolo [3',2':5,6]pyrido[2,3-b][1,4]oxazine-8-carboxamide::US20250388583, Compound 568	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83313	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83313&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			3190761	252658510							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124256	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cncnc21	InChI=1S/C15H15N5O2/c1-7-3-4-10(21)8(2)12(7)20-13(16)11(14(17)22)9-5-18-6-19-15(9)20/h3-6,21H,16H2,1-2H3,(H2,17,22)	AWGYUGPQPNQOOH-UHFFFAOYSA-N	83314	US20250388583, Compound 571	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83314	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83314&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			833601	252658511							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124257	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cncnc21	InChI=1S/C15H15N5O2/c1-7-3-4-10(21)8(2)12(7)20-13(16)11(14(17)22)9-5-18-6-19-15(9)20/h3-6,21H,16H2,1-2H3,(H2,17,22)	AWGYUGPQPNQOOH-UHFFFAOYSA-N	83315	US20250388583, Compound 572	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83315	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83315&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2947809	252658512							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124258	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(N3CC(O)C3)nc21	InChI=1S/C18H20N6O3/c1-8-3-4-12(26)9(2)14(8)24-15(19)13(16(20)27)11-5-21-18(22-17(11)24)23-6-10(25)7-23/h3-5,10,25-26H,6-7,19H2,1-2H3,(H2,20,27)	VQHWGBXNOLDJHD-UHFFFAOYSA-N	83316	US20250388583, Compound 573	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83316	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83316&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			1342009	252658513							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124259	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ncc(O)c3C)c2nc1C	InChI=1S/C17H19N5O2/c1-7-5-11-13(16(19)24)15(18)22(17(11)21-9(7)3)14-8(2)12(23)6-20-10(14)4/h5-6,23H,18H2,1-4H3,(H2,19,24)	FOMLLEZHJXWJOG-UHFFFAOYSA-N	83318	US20250388583, Compound 574	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83318	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83318&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			3763981	252658515							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124260	Cc1c(O)cc(F)c(C)c1n3c(N)c(C(N)=O)c2cc(Cl)cnc23	InChI=1S/C16H14ClFN4O2/c1-6-10(18)4-11(23)7(2)13(6)22-14(19)12(15(20)24)9-3-8(17)5-21-16(9)22/h3-5,23H,19H2,1-2H3,(H2,20,24)	UNTWNEMWGDDPCI-UHFFFAOYSA-N	83319	2-amino-5-chloro-1-(3-fluoro-5-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide::US20250388583, Compound 575	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83319&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			3600177	252658516							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124261	Cc1c(O)cc(F)c(C)c1n3c(N)c(C(N)=O)c2cc(Cl)cnc23	InChI=1S/C16H14ClFN4O2/c1-6-10(18)4-11(23)7(2)13(6)22-14(19)12(15(20)24)9-3-8(17)5-21-16(9)22/h3-5,23H,19H2,1-2H3,(H2,20,24)	UNTWNEMWGDDPCI-UHFFFAOYSA-N	83319	2-amino-5-chloro-1-(3-fluoro-5-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide::US20250388583, Compound 575	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83319	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83319&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			3600177	252658516							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124262	Cc1c(O)cc(F)c(C)c1n3c(N)c(C(N)=O)c2cc(Cl)cnc23	InChI=1S/C16H14ClFN4O2/c1-6-10(18)4-11(23)7(2)13(6)22-14(19)12(15(20)24)9-3-8(17)5-21-16(9)22/h3-5,23H,19H2,1-2H3,(H2,20,24)	UNTWNEMWGDDPCI-UHFFFAOYSA-N	83320	2-amino-5-chloro-1-(3-fluoro-5-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide::US20250388583, Compound 576	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83320&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5113115	252658517							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124263	Cc1c(O)cc(F)c(C)c1n3c(N)c(C(N)=O)c2cc(Cl)cnc23	InChI=1S/C16H14ClFN4O2/c1-6-10(18)4-11(23)7(2)13(6)22-14(19)12(15(20)24)9-3-8(17)5-21-16(9)22/h3-5,23H,19H2,1-2H3,(H2,20,24)	UNTWNEMWGDDPCI-UHFFFAOYSA-N	83320	2-amino-5-chloro-1-(3-fluoro-5-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide::US20250388583, Compound 576	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83320	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83320&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			5113115	252658517							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124264	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ccc(O)c3C)c2nc1C	InChI=1S/C18H20N4O2/c1-8-5-6-13(23)10(3)15(8)22-16(19)14(17(20)24)12-7-9(2)11(4)21-18(12)22/h5-7,23H,19H2,1-4H3,(H2,20,24)	ARBRHWRTXPWZGN-UHFFFAOYSA-N	775761	US12435090, Compound 181::US20250388583, Compound 577	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=775761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=775761&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			156869388	523188431							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124265	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ccc(O)c3C)c2nc1C	InChI=1S/C18H20N4O2/c1-8-5-6-13(23)10(3)15(8)22-16(19)14(17(20)24)12-7-9(2)11(4)21-18(12)22/h5-7,23H,19H2,1-4H3,(H2,20,24)	ARBRHWRTXPWZGN-UHFFFAOYSA-N	775761	US12435090, Compound 181::US20250388583, Compound 577	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=775761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=775761&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			156869388	523188431							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124266	Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)ccc(O)c3C)c2n1	InChI=1S/C16H17N5O2/c1-7-4-5-11(22)8(2)13(7)21-14(17)12(15(18)23)10-6-19-9(3)20-16(10)21/h4-6,22H,17H2,1-3H3,(H2,18,23)	KYVMPTABRNGPPL-UHFFFAOYSA-N	752399	US20250197405, Compound 1::US20250388583, Compound 578	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=752399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=752399&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			169238446	519650993							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124267	Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)ccc(O)c3C)c2n1	InChI=1S/C16H17N5O2/c1-7-4-5-11(22)8(2)13(7)21-14(17)12(15(18)23)10-6-19-9(3)20-16(10)21/h4-6,22H,17H2,1-3H3,(H2,18,23)	KYVMPTABRNGPPL-UHFFFAOYSA-N	752399	US20250197405, Compound 1::US20250388583, Compound 578	Tyrosine-protein kinase Lck	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=752399	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=752399&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			169238446	519650993							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124268	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(N[C@H]3CCC[C@@H]3O)nc21	InChI=1S/C20H24N6O3/c1-9-6-7-13(27)10(2)16(9)26-17(21)15(18(22)29)11-8-23-20(25-19(11)26)24-12-4-3-5-14(12)28/h6-8,12,14,27-28H,3-5,21H2,1-2H3,(H2,22,29)(H,23,24,25)	XYVZQDDCOGHINW-UHFFFAOYSA-N	83323	US20250388583, Compound 579	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83323	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83323&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5077003	252658520							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124269	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(N[C@@H]3CCC[C@H]3O)nc21	InChI=1S/C20H24N6O3/c1-9-6-7-13(27)10(2)16(9)26-17(21)15(18(22)29)11-8-23-20(25-19(11)26)24-12-4-3-5-14(12)28/h6-8,12,14,27-28H,3-5,21H2,1-2H3,(H2,22,29)(H,23,24,25)	XYVZQDDCOGHINW-UHFFFAOYSA-N	83324	US20250388583, Compound 580	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83324	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83324&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4256556	252658521							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124270	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(N3CC[C@H](O)C3)nc21	InChI=1S/C19H22N6O3/c1-9-3-4-13(27)10(2)15(9)25-16(20)14(17(21)28)12-7-22-19(23-18(12)25)24-6-5-11(26)8-24/h3-4,7,11,26-27H,5-6,8,20H2,1-2H3,(H2,21,28)	ZWLSFBHQCZUCCC-UHFFFAOYSA-N	83325	US20250388583, Compound 581	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83325	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83325&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			3606260	252658522							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124271	N#Cc1c(C)c(C)cc2c(C(N)=O)c(N)n(-c3c(C)ccc(O)c3C)c12	InChI=1S/C20H20N4O2/c1-9-5-6-15(25)12(4)17(9)24-18-13(16(19(24)22)20(23)26)7-10(2)11(3)14(18)8-21/h5-7,25H,22H2,1-4H3,(H2,23,26)	XYPCSIHXHPFCIC-UHFFFAOYSA-N	83326	US20250388583, Compound 582	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83326	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83326&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5521786	252658523							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124272	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(N3CC[C@@H](O)C3)nc21	InChI=1S/C19H22N6O3/c1-9-3-4-13(27)10(2)15(9)25-16(20)14(17(21)28)12-7-22-19(23-18(12)25)24-6-5-11(26)8-24/h3-4,7,11,26-27H,5-6,8,20H2,1-2H3,(H2,21,28)	ZWLSFBHQCZUCCC-UHFFFAOYSA-N	83327	US20250388583, Compound 583	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83327	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83327&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5211364	252658524							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124273	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(NC(=O)[C@H]3CCCN3)nc21	InChI=1S/C20H23N7O3/c1-9-5-6-13(28)10(2)15(9)27-16(21)14(17(22)29)11-8-24-20(25-18(11)27)26-19(30)12-4-3-7-23-12/h5-6,8,12,23,28H,3-4,7,21H2,1-2H3,(H2,22,29)(H,24,25,26,30)	XVWHJNHJGXPAGL-UHFFFAOYSA-N	83328	US20250388583, Compound 584	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83328	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83328&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4693332	242053757							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124274	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(NCCO)nc21	InChI=1S/C17H20N6O3/c1-8-3-4-11(25)9(2)13(8)23-14(18)12(15(19)26)10-7-21-17(20-5-6-24)22-16(10)23/h3-4,7,24-25H,5-6,18H2,1-2H3,(H2,19,26)(H,20,21,22)	OLLDAFXLQJARTF-UHFFFAOYSA-N	83329	US20250388583, Compound 585	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83329	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83329&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16187210	252658525							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124275	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83330	US20250388583, Compound 586	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83330	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83330&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16187284	252658526							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124276	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cncc(C#N)c21	InChI=1S/C17H15N5O2/c1-8-3-4-12(23)9(2)14(8)22-15-10(5-18)6-21-7-11(15)13(16(22)19)17(20)24/h3-4,6-7,23H,19H2,1-2H3,(H2,20,24)	LTHDOJYSIIRHQB-UHFFFAOYSA-N	83331	US20250388583, Compound 587	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83331	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83331&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16187377	252658527							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124277	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(NCCO)nc21	InChI=1S/C17H20N6O3/c1-8-3-4-11(25)9(2)13(8)23-14(18)12(15(19)26)10-7-21-17(20-5-6-24)22-16(10)23/h3-4,7,24-25H,5-6,18H2,1-2H3,(H2,19,26)(H,20,21,22)	OLLDAFXLQJARTF-UHFFFAOYSA-N	83332	US20250388583, Compound 588	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83332	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83332&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16187535	252658528							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124278	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(NC3CCC[C@@H]3O)nc21	InChI=1S/C20H24N6O3/c1-9-6-7-13(27)10(2)16(9)26-17(21)15(18(22)29)11-8-23-20(25-19(11)26)24-12-4-3-5-14(12)28/h6-8,12,14,27-28H,3-5,21H2,1-2H3,(H2,22,29)(H,23,24,25)	XYVZQDDCOGHINW-UHFFFAOYSA-N	83333	US20250388583, Compound 591	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83333	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83333&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16187783	252658529							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124279	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83334	US20250388583, Compound 592::US20260001879, Compound 133	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83334&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16187807	252658530							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124280	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83334	US20250388583, Compound 592::US20260001879, Compound 133	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83334	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83334&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16187807	252658530							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124281	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(NC(=O)[C@@H]3CCCN3)nc21	InChI=1S/C20H23N7O3/c1-9-5-6-13(28)10(2)15(9)27-16(21)14(17(22)29)11-8-24-20(25-18(11)27)26-19(30)12-4-3-7-23-12/h5-6,8,12,23,28H,3-4,7,21H2,1-2H3,(H2,22,29)(H,24,25,26,30)	XVWHJNHJGXPAGL-UHFFFAOYSA-N	83335	US20250388583, Compound 593	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83335&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16188233	252658531							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124282	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(NC(=O)[C@@H]3CCCN3)nc21	InChI=1S/C20H23N7O3/c1-9-5-6-13(28)10(2)15(9)27-16(21)14(17(22)29)11-8-24-20(25-18(11)27)26-19(30)12-4-3-7-23-12/h5-6,8,12,23,28H,3-4,7,21H2,1-2H3,(H2,22,29)(H,24,25,26,30)	XVWHJNHJGXPAGL-UHFFFAOYSA-N	83335	US20250388583, Compound 593	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83335	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83335&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16188233	252658531							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124283	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83336	US20250388583, Compound 594	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83336	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83336&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16188315	252658532							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124284	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)c(O)cc(I)c3C)c2nc1C	InChI=1S/C18H19IN4O2/c1-7-5-11-14(17(21)25)16(20)23(18(11)22-10(7)4)15-8(2)12(19)6-13(24)9(15)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	LMCOUIGSQUKTLL-UHFFFAOYSA-N	83337	US20250388583, Compound 595::US20260001879, Compound 219	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83337	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83337&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16188374	252658533							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124285	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83338	US20250388583, Compound 596	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83338	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83338&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16188490	252658534							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124286	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83339	US20250388583, Compound 599::US20260001879, Compound 7	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83339&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16188675	252658535							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124287	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83339	US20250388583, Compound 599::US20260001879, Compound 7	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83339	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83339&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16188675	252658535							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124288	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(-c3ccc(C(C)(C)C)cc3)nc21	InChI=1S/C25H27N5O2/c1-13-6-11-18(31)14(2)20(13)30-21(26)19(22(27)32)17-12-28-23(29-24(17)30)15-7-9-16(10-8-15)25(3,4)5/h6-12,31H,26H2,1-5H3,(H2,27,32)	GCYJHQXONOGNHZ-UHFFFAOYSA-N	83340	US20250388583, Compound 600	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83340&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			1290899	252658536							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124289	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(-c3ccc(C(C)(C)C)cc3)nc21	InChI=1S/C25H27N5O2/c1-13-6-11-18(31)14(2)20(13)30-21(26)19(22(27)32)17-12-28-23(29-24(17)30)15-7-9-16(10-8-15)25(3,4)5/h6-12,31H,26H2,1-5H3,(H2,27,32)	GCYJHQXONOGNHZ-UHFFFAOYSA-N	83340	US20250388583, Compound 600	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83340	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83340&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			1290899	252658536							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124290	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83341	US20250388583, Compound 602	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83341&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16189200	252658537							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124291	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83341	US20250388583, Compound 602	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83341	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83341&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16189200	252658537							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124292	N#Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2cc1C	InChI=1S/C19H17FN4O2/c1-8-5-14-12(6-11(8)7-21)15(19(23)26)18(22)24(14)16-9(2)4-13(20)17(25)10(16)3/h4-6,25H,22H2,1-3H3,(H2,23,26)	MAZOATKKTXUHGM-UHFFFAOYSA-N	83343	US20250388583, Compound 603	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83343&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2952313	252658539							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124293	N#Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2cc1C	InChI=1S/C19H17FN4O2/c1-8-5-14-12(6-11(8)7-21)15(19(23)26)18(22)24(14)16-9(2)4-13(20)17(25)10(16)3/h4-6,25H,22H2,1-3H3,(H2,23,26)	MAZOATKKTXUHGM-UHFFFAOYSA-N	83343	US20250388583, Compound 603	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83343	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83343&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			2952313	252658539							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124294	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83345	US20250388583, Compound 604::US20260001879, Compound 79	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83345&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16189942	252658541							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124295	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83345	US20250388583, Compound 604::US20260001879, Compound 79	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83345	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83345&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16189942	252658541							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124296	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(F)c21	InChI=1S/C19H19FN4O2/c1-8-3-6-12(25)9(2)16(8)24-17-11(13(18(24)21)19(22)26)7-23-15(14(17)20)10-4-5-10/h3,6-7,10,25H,4-5,21H2,1-2H3,(H2,22,26)	CIXMBBLIKARAMC-UHFFFAOYSA-N	83346	US20250388583, Compound 605	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83346&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16190127	252658542							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124297	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(F)c21	InChI=1S/C19H19FN4O2/c1-8-3-6-12(25)9(2)16(8)24-17-11(13(18(24)21)19(22)26)7-23-15(14(17)20)10-4-5-10/h3,6-7,10,25H,4-5,21H2,1-2H3,(H2,22,26)	CIXMBBLIKARAMC-UHFFFAOYSA-N	83346	US20250388583, Compound 605	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83346	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83346&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16190127	252658542							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124298	Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)c(O)cc(F)c3C)c2n1	InChI=1S/C16H16FN5O2/c1-6-10(17)4-11(23)7(2)13(6)22-14(18)12(15(19)24)9-5-20-8(3)21-16(9)22/h4-5,23H,18H2,1-3H3,(H2,19,24)	RUZKLCUCBKJKQG-UHFFFAOYSA-N	752407	US20250197405, Compound 6-P2::US20250388583, Compound 607	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=752407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=752407&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			170638210	519651001							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124299	Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)c(O)cc(F)c3C)c2n1	InChI=1S/C16H16FN5O2/c1-6-10(17)4-11(23)7(2)13(6)22-14(18)12(15(19)24)9-5-20-8(3)21-16(9)22/h4-5,23H,18H2,1-3H3,(H2,19,24)	RUZKLCUCBKJKQG-UHFFFAOYSA-N	752407	US20250197405, Compound 6-P2::US20250388583, Compound 607	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=752407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=752407&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			170638210	519651001							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124300	Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)c(O)cc(F)c3C)c2n1	InChI=1S/C16H16FN5O2/c1-6-10(17)4-11(23)7(2)13(6)22-14(18)12(15(19)24)9-5-20-8(3)21-16(9)22/h4-5,23H,18H2,1-3H3,(H2,19,24)	RUZKLCUCBKJKQG-UHFFFAOYSA-N	752407	US20250197405, Compound 6-P2::US20250388583, Compound 607	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=752407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=752407&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			170638210	519651001							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124301	Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)c(O)cc(F)c3C)c2n1	InChI=1S/C16H16FN5O2/c1-6-10(17)4-11(23)7(2)13(6)22-14(18)12(15(19)24)9-5-20-8(3)21-16(9)22/h4-5,23H,18H2,1-3H3,(H2,19,24)	RUZKLCUCBKJKQG-UHFFFAOYSA-N	752407	US20250197405, Compound 6-P2::US20250388583, Compound 607	Tyrosine-protein kinase Lck	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=752407	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=752407&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			170638210	519651001							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124302	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83349	US20250388583, Compound 608	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83349	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83349&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16190489	252658545							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124303	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83350	US20250388583, Compound 609	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83350	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83350&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16190607	252658546							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124304	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83351	US20250388583, Compound 616	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83351	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83351&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16190821	252658547							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124305	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83352	US20250388583, Compound 617	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83352	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83352&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191129	252658548							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124306	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)ccc(=O)n3C)c2nc1C	InChI=1S/C17H19N5O2/c1-8-5-6-12(23)21(4)17(8)22-14(18)13(15(19)24)11-7-9(2)10(3)20-16(11)22/h5-7H,18H2,1-4H3,(H2,19,24)	BQUWZEWGKDZMOA-UHFFFAOYSA-N	83353	US20250388583, Compound 618::US20260001879, Compound 178	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83353	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83353&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191191	252658549							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124307	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)c(O)cc(Cl)c3C)c2nc1C	InChI=1S/C18H19ClN4O2/c1-7-5-11-14(17(21)25)16(20)23(18(11)22-10(7)4)15-8(2)12(19)6-13(24)9(15)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	BVGDVITZLNADHH-UHFFFAOYSA-N	83354	US20250388583, Compound 619::US20260001879, Compound 195	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83354	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83354&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191320	252658550							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124308	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83355	US20250388583, Compound 620	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83355	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83355&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191458	252658551							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124309	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C#CC3CC3)nc21	InChI=1S/C20H19N5O2/c1-10-3-7-14(26)11(2)17(10)25-18(21)16(19(22)27)13-9-23-15(24-20(13)25)8-6-12-4-5-12/h3,7,9,12,26H,4-5,21H2,1-2H3,(H2,22,27)	SCQYEIKSXFQDCL-UHFFFAOYSA-N	83356	US20250388583, Compound 621	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83356	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83356&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191631	252658552							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124310	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C#Cc3ccc(F)cc3)c(F)c21	InChI=1S/C24H18F2N4O2/c1-12-3-10-18(31)13(2)21(12)30-22-16(19(23(30)27)24(28)32)11-29-17(20(22)26)9-6-14-4-7-15(25)8-5-14/h3-5,7-8,10-11,31H,27H2,1-2H3,(H2,28,32)	UWZYEAPLJLLJJD-UHFFFAOYSA-N	83357	US20250388583, Compound 622	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83357	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83357&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191646	252658553							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124311	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(F)c21	InChI=1S/C19H18F2N4O2/c1-7-11(20)5-12(26)8(2)16(7)25-17-10(13(18(25)22)19(23)27)6-24-15(14(17)21)9-3-4-9/h5-6,9,26H,3-4,22H2,1-2H3,(H2,23,27)	FLNQTSCBXRXFGB-UHFFFAOYSA-N	83358	US20250388583, Compound 623	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83358	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83358&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191792	252658554							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124312	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cncc(F)c21	InChI=1S/C16H15FN4O2/c1-7-3-4-11(22)8(2)13(7)21-14-9(5-20-6-10(14)17)12(15(21)18)16(19)23/h3-6,22H,18H2,1-2H3,(H2,19,23)	RIQYUCYHEMJMIC-UHFFFAOYSA-N	83359	US20250388583, Compound 624	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83359	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83359&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191853	252658555							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124313	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(S(C)(=O)=O)nc21	InChI=1S/C16H17N5O4S/c1-7-4-5-10(22)8(2)12(7)21-13(17)11(14(18)23)9-6-19-16(20-15(9)21)26(3,24)25/h4-6,22H,17H2,1-3H3,(H2,18,23)	VKVJSZAIHISBSB-UHFFFAOYSA-N	83360	US20250388583, Compound 625	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83360	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83360&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16191931	252658556							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124314	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)N(C)CC3	InChI=1S/C19H21N5O2/c1-9-4-5-13(25)10(2)15(9)24-16(20)14(17(21)26)12-8-11-6-7-23(3)18(11)22-19(12)24/h4-5,8,25H,6-7,20H2,1-3H3,(H2,21,26)	GKTSKYQILZLDFJ-UHFFFAOYSA-N	83361	US20250388583, Compound 630::US20260001879, Compound 92	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83361&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16192255	252658557							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124315	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)N(C)CC3	InChI=1S/C19H21N5O2/c1-9-4-5-13(25)10(2)15(9)24-16(20)14(17(21)26)12-8-11-6-7-23(3)18(11)22-19(12)24/h4-5,8,25H,6-7,20H2,1-3H3,(H2,21,26)	GKTSKYQILZLDFJ-UHFFFAOYSA-N	83361	US20250388583, Compound 630::US20260001879, Compound 92	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83361	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83361&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16192255	252658557							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124316	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83362	US20250388583, Compound 631	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83362&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16192289	252658558							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124317	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83362	US20250388583, Compound 631	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83362	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83362&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16192289	252658558							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124318	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83363	US20250388583, Compound 632	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83363&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2862070	252658559							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124319	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83363	US20250388583, Compound 632	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83363	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83363&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			2862070	252658559							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124320	COc1cc(F)c(C)c(-n2c(N)c(C(N)=O)c3cc(C)c(C)nc32)c1C	InChI=1S/C19H21FN4O2/c1-8-6-12-15(18(22)25)17(21)24(19(12)23-11(8)4)16-9(2)13(20)7-14(26-5)10(16)3/h6-7H,21H2,1-5H3,(H2,22,25)	PSADUKURWBVRHK-UHFFFAOYSA-N	83364	US20250388583, Compound 633	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83364&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			1432812	252658560							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124321	COc1cc(F)c(C)c(-n2c(N)c(C(N)=O)c3cc(C)c(C)nc32)c1C	InChI=1S/C19H21FN4O2/c1-8-6-12-15(18(22)25)17(21)24(19(12)23-11(8)4)16-9(2)13(20)7-14(26-5)10(16)3/h6-7H,21H2,1-5H3,(H2,22,25)	PSADUKURWBVRHK-UHFFFAOYSA-N	83364	US20250388583, Compound 633	Tyrosine-protein kinase Lck	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83364	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83364&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			1432812	252658560							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124322	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83365	US20250388583, Compound 634	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83365&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2862002	252658561							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124323	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83365	US20250388583, Compound 634	Tyrosine-protein kinase Lck	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83365	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83365&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			2862002	252658561							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124324	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83366	US20250388583, Compound 635	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83366&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			612020	252658562							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124325	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83366	US20250388583, Compound 635	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83366	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83366&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			612020	252658562							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124326	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(CCc3cscn3)c(F)c21	InChI=1S/C21H20FN5O2S/c1-10-3-6-15(28)11(2)18(10)27-19-13(16(20(27)23)21(24)29)7-25-14(17(19)22)5-4-12-8-30-9-26-12/h3,6-9,28H,4-5,23H2,1-2H3,(H2,24,29)	HFXMZXQALOFLDR-UHFFFAOYSA-N	83367	US20250388583, Compound 638	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83367&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2860484	252658563							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124327	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(CCc3cscn3)c(F)c21	InChI=1S/C21H20FN5O2S/c1-10-3-6-15(28)11(2)18(10)27-19-13(16(20(27)23)21(24)29)7-25-14(17(19)22)5-4-12-8-30-9-26-12/h3,6-9,28H,4-5,23H2,1-2H3,(H2,24,29)	HFXMZXQALOFLDR-UHFFFAOYSA-N	83367	US20250388583, Compound 638	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83367	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83367&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			2860484	252658563							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124328	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83368	US20250388583, Compound 639	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83368&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16193242	252658564							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124329	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3C)c2nc1C	InChI=1S/C18H19FN4O2/c1-7-5-11-13(17(21)25)16(20)23(18(11)22-10(7)4)14-8(2)6-12(19)15(24)9(14)3/h5-6,24H,20H2,1-4H3,(H2,21,25)	RTZAJUVZWJYWOM-UHFFFAOYSA-N	83368	US20250388583, Compound 639	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83368	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83368&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16193242	252658564							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124330	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83369	US20250388583, Compound 640	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83369&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5113104	252658565							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124331	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83369	US20250388583, Compound 640	Tyrosine-protein kinase Lck	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83369	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83369&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			5113104	252658565							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124332	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83370	US20250388583, Compound 641	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83370&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5113106	252658566							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124333	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83370	US20250388583, Compound 641	Tyrosine-protein kinase Lck	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83370	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83370&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			5113106	252658566							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124334	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(CCc3cncs3)c(F)c21	InChI=1S/C21H20FN5O2S/c1-10-3-6-15(28)11(2)18(10)27-19-13(16(20(27)23)21(24)29)8-26-14(17(19)22)5-4-12-7-25-9-30-12/h3,6-9,28H,4-5,23H2,1-2H3,(H2,24,29)	SLFDMSGHKSDTIY-UHFFFAOYSA-N	83371	US20250388583, Compound 642	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83371&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16193682	252658567							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124335	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(CCc3cncs3)c(F)c21	InChI=1S/C21H20FN5O2S/c1-10-3-6-15(28)11(2)18(10)27-19-13(16(20(27)23)21(24)29)8-26-14(17(19)22)5-4-12-7-25-9-30-12/h3,6-9,28H,4-5,23H2,1-2H3,(H2,24,29)	SLFDMSGHKSDTIY-UHFFFAOYSA-N	83371	US20250388583, Compound 642	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83371	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83371&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16193682	252658567							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124336	Cc1cc2c(C(N)=O)c(N)n(-c3c(Cl)cc(F)c(O)c3C)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-12(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)14(24)11(19)5-10(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	MRHTXDYOSDLNLI-UHFFFAOYSA-N	83372	US20250388583, Compound 647	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83372&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16194542	252658568							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124337	Cc1cc2c(C(N)=O)c(N)n(-c3c(Cl)cc(F)c(O)c3C)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-12(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)14(24)11(19)5-10(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	MRHTXDYOSDLNLI-UHFFFAOYSA-N	83372	US20250388583, Compound 647	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83372	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83372&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16194542	252658568							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124338	Cc1ccc(O)c(C)c1n3c(N)c(C(N)=O)c2cnc(C#CC(F)(F)F)nc23	InChI=1S/C18H14F3N5O2/c1-8-3-4-11(27)9(2)14(8)26-15(22)13(16(23)28)10-7-24-12(25-17(10)26)5-6-18(19,20)21/h3-4,7,27H,22H2,1-2H3,(H2,23,28)	GYYPTHDAXOVLNF-UHFFFAOYSA-N	83373	US20250388583, Compound 648	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83373&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16194620	252658569							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124339	Cc1ccc(O)c(C)c1n3c(N)c(C(N)=O)c2cnc(C#CC(F)(F)F)nc23	InChI=1S/C18H14F3N5O2/c1-8-3-4-11(27)9(2)14(8)26-15(22)13(16(23)28)10-7-24-12(25-17(10)26)5-6-18(19,20)21/h3-4,7,27H,22H2,1-2H3,(H2,23,28)	GYYPTHDAXOVLNF-UHFFFAOYSA-N	83373	US20250388583, Compound 648	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83373	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83373&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16194620	252658569							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124340	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(CCc3nccs3)c(F)c21	InChI=1S/C21H20FN5O2S/c1-10-3-5-14(28)11(2)18(10)27-19-12(16(20(27)23)21(24)29)9-26-13(17(19)22)4-6-15-25-7-8-30-15/h3,5,7-9,28H,4,6,23H2,1-2H3,(H2,24,29)	XJJDQSZOMRZSIA-UHFFFAOYSA-N	83374	US20250388583, Compound 649	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83374&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			16195712	252658570							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124341	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(CCc3nccs3)c(F)c21	InChI=1S/C21H20FN5O2S/c1-10-3-5-14(28)11(2)18(10)27-19-12(16(20(27)23)21(24)29)9-26-13(17(19)22)4-6-15-25-7-8-30-15/h3,5,7-9,28H,4,6,23H2,1-2H3,(H2,24,29)	XJJDQSZOMRZSIA-UHFFFAOYSA-N	83374	US20250388583, Compound 649	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83374	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83374&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			16195712	252658570							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124342	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83375	US20250388583, Compound 650	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83375&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			3593394	252658571							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124343	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3	InChI=1S/C18H19N5O2/c1-8-3-4-13(24)9(2)15(8)23-16(19)14(17(20)25)10-7-12-11(5-6-21-12)22-18(10)23/h3-4,7,21,24H,5-6,19H2,1-2H3,(H2,20,25)	GBHPPLDUKJONJD-UHFFFAOYSA-N	83375	US20250388583, Compound 650	Tyrosine-protein kinase Lck	Homo sapiens		 75							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83375	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83375&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			3593394	252658571							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124344	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(/C=C/C3CC3)nc21	InChI=1S/C20H21N5O2/c1-10-3-7-14(26)11(2)17(10)25-18(21)16(19(22)27)13-9-23-15(24-20(13)25)8-6-12-4-5-12/h3,6-9,12,26H,4-5,21H2,1-2H3,(H2,22,27)	FPPOIPUOELRYDN-UHFFFAOYSA-N	83376	US20250388583, Compound 651	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83376&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			6223980	252658572							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124345	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(/C=C/C3CC3)nc21	InChI=1S/C20H21N5O2/c1-10-3-7-14(26)11(2)17(10)25-18(21)16(19(22)27)13-9-23-15(24-20(13)25)8-6-12-4-5-12/h3,6-9,12,26H,4-5,21H2,1-2H3,(H2,22,27)	FPPOIPUOELRYDN-UHFFFAOYSA-N	83376	US20250388583, Compound 651	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83376	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83376&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			6223980	252658572							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124346	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83377	US20250388583, Compound 652	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83377&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			3556099	252658573							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124347	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)COC3	InChI=1S/C18H17FN4O3/c1-7-11(19)4-13(24)8(2)15(7)23-16(20)14(17(21)25)10-3-9-5-26-6-12(9)22-18(10)23/h3-4,24H,5-6,20H2,1-2H3,(H2,21,25)	JAQCENSBCDTRNX-UHFFFAOYSA-N	83377	US20250388583, Compound 652	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83377	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83377&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			3556099	252658573							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124348	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3ncn(C)c3nc21	InChI=1S/C18H18N6O2/c1-8-4-5-12(25)9(2)14(8)24-15(19)13(16(20)26)10-6-11-18(22-17(10)24)23(3)7-21-11/h4-7,25H,19H2,1-3H3,(H2,20,26)	INPIERSDHYIVQL-UHFFFAOYSA-N	83378	US20250388583, Compound 653::US20260001879, Compound 65	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83378&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4881395	252658574							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124349	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3ncn(C)c3nc21	InChI=1S/C18H18N6O2/c1-8-4-5-12(25)9(2)14(8)24-15(19)13(16(20)26)10-6-11-18(22-17(10)24)23(3)7-21-11/h4-7,25H,19H2,1-3H3,(H2,20,26)	INPIERSDHYIVQL-UHFFFAOYSA-N	83378	US20250388583, Compound 653::US20260001879, Compound 65	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83378	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83378&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4881395	252658574							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124350	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(F)c21	InChI=1S/C19H18F2N4O2/c1-7-11(20)5-12(26)8(2)16(7)25-17-10(13(18(25)22)19(23)27)6-24-15(14(17)21)9-3-4-9/h5-6,9,26H,3-4,22H2,1-2H3,(H2,23,27)	FLNQTSCBXRXFGB-UHFFFAOYSA-N	83379	US20250388583, Compound 655	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83379&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4879431	252658575							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124351	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(F)c21	InChI=1S/C19H18F2N4O2/c1-7-11(20)5-12(26)8(2)16(7)25-17-10(13(18(25)22)19(23)27)6-24-15(14(17)21)9-3-4-9/h5-6,9,26H,3-4,22H2,1-2H3,(H2,23,27)	FLNQTSCBXRXFGB-UHFFFAOYSA-N	83379	US20250388583, Compound 655	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83379	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83379&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4879431	252658575							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124352	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)nc21	InChI=1S/C18H18FN5O2/c1-7-11(19)5-12(25)8(2)14(7)24-15(20)13(16(21)26)10-6-22-17(9-3-4-9)23-18(10)24/h5-6,9,25H,3-4,20H2,1-2H3,(H2,21,26)	KTTCADMAOXUPEY-UHFFFAOYSA-N	83380	US20250388583, Compound 656	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83380&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			2417585	252658576							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124353	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)nc21	InChI=1S/C18H18FN5O2/c1-7-11(19)5-12(25)8(2)14(7)24-15(20)13(16(21)26)10-6-22-17(9-3-4-9)23-18(10)24/h5-6,9,25H,3-4,20H2,1-2H3,(H2,21,26)	KTTCADMAOXUPEY-UHFFFAOYSA-N	83380	US20250388583, Compound 656	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83380	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83380&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			2417585	252658576							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124354	CCc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C)nc21	InChI=1S/C17H18FN5O2/c1-4-9-12(24)5-11(18)7(2)14(9)23-15(19)13(16(20)25)10-6-21-8(3)22-17(10)23/h5-6,24H,4,19H2,1-3H3,(H2,20,25)	NVPFVUOMUFYKCM-UHFFFAOYSA-N	83381	US20250388583, Compound 659	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83381&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4391932	252658577							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124355	CCc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C)nc21	InChI=1S/C17H18FN5O2/c1-4-9-12(24)5-11(18)7(2)14(9)23-15(19)13(16(20)25)10-6-21-8(3)22-17(10)23/h5-6,24H,4,19H2,1-3H3,(H2,20,25)	NVPFVUOMUFYKCM-UHFFFAOYSA-N	83381	US20250388583, Compound 659	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83381	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83381&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4391932	252658577							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124356	Cc1cc2c(C(N)=O)c(N)n(-c3c(Cl)cc(F)c(O)c3C)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-12(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)14(24)11(19)5-10(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	MRHTXDYOSDLNLI-UHFFFAOYSA-N	83382	US20250388583, Compound 660	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83382&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4885516	252658578							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124357	Cc1cc2c(C(N)=O)c(N)n(-c3c(Cl)cc(F)c(O)c3C)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-12(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)14(24)11(19)5-10(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	MRHTXDYOSDLNLI-UHFFFAOYSA-N	83382	US20250388583, Compound 660	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83382	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83382&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4885516	252658578							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124358	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3C	InChI=1S/C19H21N5O2/c1-9-4-5-14(25)10(2)16(9)24-17(20)15(18(21)26)11-8-13-12(22-19(11)24)6-7-23(13)3/h4-5,8,25H,6-7,20H2,1-3H3,(H2,21,26)	SPBRRAPNCVKGML-UHFFFAOYSA-N	83383	US20250388583, Compound 661::US20260001879, Compound 89	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83383&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5126827	252658579							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124359	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc3c(nc21)CCN3C	InChI=1S/C19H21N5O2/c1-9-4-5-14(25)10(2)16(9)24-17(20)15(18(21)26)11-8-13-12(22-19(11)24)6-7-23(13)3/h4-5,8,25H,6-7,20H2,1-3H3,(H2,21,26)	SPBRRAPNCVKGML-UHFFFAOYSA-N	83383	US20250388583, Compound 661::US20260001879, Compound 89	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83383	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83383&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			5126827	252658579							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124360	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(C#N)c21	InChI=1S/C20H19N5O2/c1-9-3-6-14(26)10(2)17(9)25-18-12(7-21)16(11-4-5-11)24-8-13(18)15(19(25)22)20(23)27/h3,6,8,11,26H,4-5,22H2,1-2H3,(H2,23,27)	LGCOSSUMLDHWKM-UHFFFAOYSA-N	83384	US20250388583, Compound 662	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83384&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			4883199	252658580							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124361	Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(C#N)c21	InChI=1S/C20H19N5O2/c1-9-3-6-14(26)10(2)17(9)25-18-12(7-21)16(11-4-5-11)24-8-13(18)15(19(25)22)20(23)27/h3,6,8,11,26H,4-5,22H2,1-2H3,(H2,23,27)	LGCOSSUMLDHWKM-UHFFFAOYSA-N	83384	US20250388583, Compound 662	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83384	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83384&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			4883199	252658580							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124362	Cc1cc2c(C(N)=O)c(N)n(-c3c(Cl)cc(F)c(O)c3C)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-12(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)14(24)11(19)5-10(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	MRHTXDYOSDLNLI-UHFFFAOYSA-N	83385	US20250388583, Compound 663	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83385&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			3561082	252658581							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124363	Cc1cc2c(C(N)=O)c(N)n(-c3c(Cl)cc(F)c(O)c3C)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-12(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)14(24)11(19)5-10(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	MRHTXDYOSDLNLI-UHFFFAOYSA-N	83385	US20250388583, Compound 663	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83385	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83385&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			3561082	252658581							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124364	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(C#N)c21	InChI=1S/C20H18FN5O2/c1-8-13(21)5-14(27)9(2)17(8)26-18-11(6-22)16(10-3-4-10)25-7-12(18)15(19(26)23)20(24)28/h5,7,10,27H,3-4,23H2,1-2H3,(H2,24,28)	AZLSVXQIZLENGR-UHFFFAOYSA-N	83386	US20250388583, Compound 667	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83386&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			650175	252658582							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124365	Cc1c(O)cc(F)c(C)c1-n1c(N)c(C(N)=O)c2cnc(C3CC3)c(C#N)c21	InChI=1S/C20H18FN5O2/c1-8-13(21)5-14(27)9(2)17(8)26-18-11(6-22)16(10-3-4-10)25-7-12(18)15(19(26)23)20(24)28/h5,7,10,27H,3-4,23H2,1-2H3,(H2,24,28)	AZLSVXQIZLENGR-UHFFFAOYSA-N	83386	US20250388583, Compound 667	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83386	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83386&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			650175	252658582							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124366	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3Cl)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-11(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)5-10(19)14(24)12(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	FWAQLKAOEDPADS-UHFFFAOYSA-N	83387	US20250388583, Compound 673::US20260001879, Compound 8	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83387&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			650185	252658583							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124367	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc(F)c(O)c3Cl)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-11(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)5-10(19)14(24)12(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	FWAQLKAOEDPADS-UHFFFAOYSA-N	83387	US20250388583, Compound 673::US20260001879, Compound 8	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83387	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83387&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			650185	252658583							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124368	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc4c(c3C)OCC4)c2nc1C	InChI=1S/C20H22N4O2/c1-9-8-14-15(19(22)25)18(21)24(20(14)23-12(9)4)16-10(2)7-13-5-6-26-17(13)11(16)3/h7-8H,5-6,21H2,1-4H3,(H2,22,25)	ZHANYPJVRNJOFM-UHFFFAOYSA-N	83389	US20250388583, Compound 675::US20260001879, Compound 152	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83389&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5461577	252658585							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124369	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc4c(c3C)OCC4)c2nc1C	InChI=1S/C20H22N4O2/c1-9-8-14-15(19(22)25)18(21)24(20(14)23-12(9)4)16-10(2)7-13-5-6-26-17(13)11(16)3/h7-8H,5-6,21H2,1-4H3,(H2,22,25)	ZHANYPJVRNJOFM-UHFFFAOYSA-N	83389	US20250388583, Compound 675::US20260001879, Compound 152	Tyrosine-protein kinase Lck	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83389	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83389&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			5461577	252658585							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124370	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc4c(c3C)OCC4)c2nc1C	InChI=1S/C20H22N4O2/c1-9-8-14-15(19(22)25)18(21)24(20(14)23-12(9)4)16-10(2)7-13-5-6-26-17(13)11(16)3/h7-8H,5-6,21H2,1-4H3,(H2,22,25)	ZHANYPJVRNJOFM-UHFFFAOYSA-N	83390	US20250388583, Compound 678	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83390&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			5461578	252658586							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124371	Cc1cc2c(C(N)=O)c(N)n(-c3c(C)cc4c(c3C)OCC4)c2nc1C	InChI=1S/C20H22N4O2/c1-9-8-14-15(19(22)25)18(21)24(20(14)23-12(9)4)16-10(2)7-13-5-6-26-17(13)11(16)3/h7-8H,5-6,21H2,1-4H3,(H2,22,25)	ZHANYPJVRNJOFM-UHFFFAOYSA-N	83390	US20250388583, Compound 678	Tyrosine-protein kinase Lck	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83390	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83390&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			5461578	252658586							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124372	Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)cc4[nH]c(=O)oc4c3C)c2n1	InChI=1S/C17H16N6O3/c1-6-4-10-13(26-17(25)22-10)7(2)12(6)23-14(18)11(15(19)24)9-5-20-8(3)21-16(9)23/h4-5H,18H2,1-3H3,(H2,19,24)(H,22,25)	UZICZHDNECQWRG-UHFFFAOYSA-N	83391	US20250388583, Compound 680	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83391&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			23641069	252658587							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124373	Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)cc4[nH]c(=O)oc4c3C)c2n1	InChI=1S/C17H16N6O3/c1-6-4-10-13(26-17(25)22-10)7(2)12(6)23-14(18)11(15(19)24)9-5-20-8(3)21-16(9)23/h4-5H,18H2,1-3H3,(H2,19,24)(H,22,25)	UZICZHDNECQWRG-UHFFFAOYSA-N	83391	US20250388583, Compound 680	Tyrosine-protein kinase Lck	Homo sapiens		>1000							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83391	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83391&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			23641069	252658587							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124374	Cc1cc2c(C(N)=O)c(N)n(-c3c(Cl)cc(F)c(O)c3C)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-12(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)14(24)11(19)5-10(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	MRHTXDYOSDLNLI-UHFFFAOYSA-N	83392	US20250388583, Compound 681::US20260001879, Compound 4	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens		 550							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50003053&target=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83392&enzyme=Membrane-associated+tyrosine-+and+threonine-specific+cdc2-inhibitory+kinase&column=ki&startPg=0&Increment=50&submit=Search			798349	252658588							1	MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT	9M6P,8WJY,8D6F,8D6E,8D6D,8D6C,5VD3,5VD1,5VD0,5VCZ,5VCY,5VCX,5VCW,5VCV,3P1A,9LID,9LGV,8ZTX,9LGL,8ZUL,8ZUD,8ZU2,23FW,23ES,9LGN	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1_HUMAN	Q99640	B3KUN8 B4DXD4 D3DUA4 F8W164 I3L1V2 O14731 Q7LE24 Q8TCM9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
124375	Cc1cc2c(C(N)=O)c(N)n(-c3c(Cl)cc(F)c(O)c3C)c2nc1C	InChI=1S/C17H16ClFN4O2/c1-6-4-9-12(16(21)25)15(20)23(17(9)22-8(6)3)13-7(2)14(24)11(19)5-10(13)18/h4-5,24H,20H2,1-3H3,(H2,21,25)	MRHTXDYOSDLNLI-UHFFFAOYSA-N	83392	US20250388583, Compound 681::US20260001879, Compound 4	Tyrosine-protein kinase Lck	Homo sapiens		<50							US Patent		10.7270/Q2736WPT			US20250388583	Kline, T; Khrakovsky, D; Namjoshi, O; Phadke, S; Harrison, S; Brew, CT; Duncton, MA	12/25/2025	5/6/2026	Engine Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83392	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=507&target=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83392&enzyme=Tyrosine-protein+kinase+Lck&column=ki&startPg=0&Increment=50&submit=Search			798349	252658588							1	MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP	3KXZ,6PDJ,3AD6,3AD5,3AD4,3ACK,3ACJ,3AC8,3AC5,3AC4,3AC3,3AC2,3AC1,2ZYB,2ZM4,2ZM1,2PL0,1QPJ,1QPE,1QPC,3BYU,3BYS,3B2W,2OFV,2OFU,3BYM,3LCK,3BYO,2OF4,2OF2,2OG8,1LCK,4D8K,1X27	Tyrosine-protein kinase Lck	LCK_HUMAN	P06239	D3DPP8 P07100 Q12850 Q13152 Q5TDH8 Q5TDH9 Q7RTZ3 Q96DW4 Q9NYT8