BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 124376 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cccc(Cl)c5Cl)CC4)cnc3c2c1 InChI=1S/C24H23Cl2N5O2/c1-15-5-6-18-16(13-15)22-23(28-18)24(33)31(14-27-22)8-7-20(32)30-11-9-29(10-12-30)19-4-2-3-17(25)21(19)26/h2-6,13-14,28H,7-12H2,1H3 NRHPDSHQHIGPIB-UHFFFAOYSA-N 83321 3-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)-3-oxopropyl)-8-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 1 Thiamine pyrophosphokinase 1 110 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83321 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83321&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 5077002 252658518 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124377 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cc(Cl)ccc5Cl)CC4)cnc3c2c1 InChI=1S/C24H23Cl2N5O2/c1-15-2-5-19-17(12-15)22-23(28-19)24(33)31(14-27-22)7-6-21(32)30-10-8-29(9-11-30)20-13-16(25)3-4-18(20)26/h2-5,12-14,28H,6-11H2,1H3 FWXJGVQFGXEYFI-UHFFFAOYSA-N 83322 3-(3-(4-(2,5-dichlorophenyl)piperazin-1-yl)-3-oxopropyl)-8-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 2 Thiamine pyrophosphokinase 1 2048 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83322 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83322&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 3418043 252658519 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124378 Cc1ccc2c(c1)[nH]c1c(=O)n(CCC(=O)N3CCN(c4ccc(Cl)cc4Cl)CC3)cnc12 InChI=1S/C24H23Cl2N5O2/c1-15-2-4-17-19(12-15)28-23-22(17)27-14-31(24(23)33)7-6-21(32)30-10-8-29(9-11-30)20-5-3-16(25)13-18(20)26/h2-5,12-14,28H,6-11H2,1H3 VLWSNVWBTZMMBQ-UHFFFAOYSA-N 83347 3-(3-(4-(2,4-dichlorophenyl)piperazin-1-yl)-3-oxopropyl)-7-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 3 Thiamine pyrophosphokinase 1 1784 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83347 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83347&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16190428 252658543 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124379 O=C(CCn1cnc2c([nH]c3ccccc32)c1=O)N1CCN(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C24H22F3N5O2/c25-24(26,27)16-4-3-5-17(14-16)30-10-12-31(13-11-30)20(33)8-9-32-15-28-21-18-6-1-2-7-19(18)29-22(21)23(32)34/h1-7,14-15,29H,8-13H2 PYDUVZQBDMCIHF-UHFFFAOYSA-N 83348 3-(3-oxo-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 5 Thiamine pyrophosphokinase 1 2290 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83348 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83348&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16190448 252658544 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124380 O=C(CCn1cnc2c([nH]c3ccc(C(F)(F)F)cc32)c1=O)N1CCN(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C25H21F6N5O2/c26-24(27,28)15-2-1-3-17(12-15)34-8-10-35(11-9-34)20(37)6-7-36-14-32-21-18-13-16(25(29,30)31)4-5-19(18)33-22(21)23(36)38/h1-5,12-14,33H,6-11H2 DCWNIRCRZVHYMQ-UHFFFAOYSA-N 83393 3-(3-oxo-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)-8-(trifluoromethyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 6 Thiamine pyrophosphokinase 1 1032 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83393&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 44686 252658589 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124381 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5ccc(Cl)cc5Cl)CC4)cnc3c2c1 InChI=1S/C24H23Cl2N5O2/c1-15-2-4-19-17(12-15)22-23(28-19)24(33)31(14-27-22)7-6-21(32)30-10-8-29(9-11-30)20-5-3-16(25)13-18(20)26/h2-5,12-14,28H,6-11H2,1H3 ZINANNXZQRNFGH-UHFFFAOYSA-N 83398 3-(3-(4-(2,4-dichlorophenyl)piperazin-1-yl)-3-oxopropyl)-8-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 7 Thiamine pyrophosphokinase 1 2319 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83398 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83398&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 2965324 252658594 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124382 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5ccc(Cl)c(Cl)c5)CC4)cnc3c2c1 InChI=1S/C24H23Cl2N5O2/c1-15-2-5-20-17(12-15)22-23(28-20)24(33)31(14-27-22)7-6-21(32)30-10-8-29(9-11-30)16-3-4-18(25)19(26)13-16/h2-5,12-14,28H,6-11H2,1H3 XDIFIRARWOHVKK-UHFFFAOYSA-N 83399 3-(3-(4-(3,4-dichlorophenyl)piperazin-1-yl)-3-oxopropyl)-8-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 9 Thiamine pyrophosphokinase 1 768 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83399 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83399&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16437666 252658595 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124383 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5ccc(C(F)(F)F)cc5)CC4)cnc3c2c1 InChI=1S/C25H24F3N5O2/c1-16-2-7-20-19(14-16)22-23(30-20)24(35)33(15-29-22)9-8-21(34)32-12-10-31(11-13-32)18-5-3-17(4-6-18)25(26,27)28/h2-7,14-15,30H,8-13H2,1H3 CQOFTBWWTQNJCH-UHFFFAOYSA-N 83400 8-methyl-3-(3-oxo-3-(4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 10 Thiamine pyrophosphokinase 1 1150 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83400 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83400&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 1765347 252658596 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124384 Cc1cccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)cnc3c12 InChI=1S/C25H24F3N5O2/c1-16-4-2-7-19-21(16)22-23(30-19)24(35)33(15-29-22)9-8-20(34)32-12-10-31(11-13-32)18-6-3-5-17(14-18)25(26,27)28/h2-7,14-15,30H,8-13H2,1H3 KRBKPTFUSNEGSA-UHFFFAOYSA-N 83401 9-methyl-3-(3-oxo-3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 11 Thiamine pyrophosphokinase 1 1075 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83401 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83401&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 7696510 252658597 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124385 Cc1ccc2c(c1)[nH]c1c(=O)n(CCC(=O)N3CCN(c4cc(Cl)ccc4Cl)CC3)cnc12 InChI=1S/C24H23Cl2N5O2/c1-15-2-4-17-19(12-15)28-23-22(17)27-14-31(24(23)33)7-6-21(32)30-10-8-29(9-11-30)20-13-16(25)3-5-18(20)26/h2-5,12-14,28H,6-11H2,1H3 WJMDXRQCUPBQHD-UHFFFAOYSA-N 83402 3-(3-(4-(2,5-dichlorophenyl)piperazin-1-yl)-3-oxopropyl)-7-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 14 Thiamine pyrophosphokinase 1 2444 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83402 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83402&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4796915 252658598 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124386 Cc1ccc2[nH]c3c(=O)n(CCCC(=O)N4CCN(c5cccc(Cl)c5Cl)CC4)cnc3c2c1 InChI=1S/C25H25Cl2N5O2/c1-16-7-8-19-17(14-16)23-24(29-19)25(34)32(15-28-23)9-3-6-21(33)31-12-10-30(11-13-31)20-5-2-4-18(26)22(20)27/h2,4-5,7-8,14-15,29H,3,6,9-13H2,1H3 FNYVIWUYVSOLGN-UHFFFAOYSA-N 83403 3-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-4-oxobutyl)-8-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 15 Thiamine pyrophosphokinase 1 463 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83403 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83403&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4883447 252658599 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124387 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cc(C(F)(F)F)cc(C(F)(F)F)c5)CC4)cnc3c2c1 InChI=1S/C26H23F6N5O2/c1-15-2-3-20-19(10-15)22-23(34-20)24(39)37(14-33-22)5-4-21(38)36-8-6-35(7-9-36)18-12-16(25(27,28)29)11-17(13-18)26(30,31)32/h2-3,10-14,34H,4-9H2,1H3 JNNXNWFQXLOYKS-UHFFFAOYSA-N 83404 3-(3-(4-(3,5-bis(trifluoromethyl)phenyl)piperazin-1-yl)-3-oxopropyl)-8-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 16 Thiamine pyrophosphokinase 1 360 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83404&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 2809776 252658600 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124388 Cc1ccc2c(c1)[nH]c1c(=O)n(CCC(=O)N3CCN(c4ccc(Cl)c(Cl)c4)CC3)cnc12 InChI=1S/C24H23Cl2N5O2/c1-15-2-4-17-20(12-15)28-23-22(17)27-14-31(24(23)33)7-6-21(32)30-10-8-29(9-11-30)16-3-5-18(25)19(26)13-16/h2-5,12-14,28H,6-11H2,1H3 OVXSGKZRWIUJRG-UHFFFAOYSA-N 83405 3-(3-(4-(3,4-dichlorophenyl)piperazin-1-yl)-3-oxopropyl)-7-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 19 Thiamine pyrophosphokinase 1 1999 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83405 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83405&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16288533 252658601 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124389 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cccc(N)c5)CC4)cnc3c2c1 InChI=1S/C24H26N6O2/c1-16-5-6-20-19(13-16)22-23(27-20)24(32)30(15-26-22)8-7-21(31)29-11-9-28(10-12-29)18-4-2-3-17(25)14-18/h2-6,13-15,27H,7-12,25H2,1H3 KHZHTXOAXZRUDR-UHFFFAOYSA-N 83406 3-(4-(3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanoyl)piperazin-1-yl)benzoic Acid ::US20250388584, Example 26 Thiamine pyrophosphokinase 1 2616 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83406&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 2818470 252658602 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124390 Cc1ccc(N2CCN(C(=O)CCn3cnc4c([nH]c5ccc(C)cc54)c3=O)CC2)c(C)c1 InChI=1S/C26H29N5O2/c1-17-5-7-22(19(3)14-17)29-10-12-30(13-11-29)23(32)8-9-31-16-27-24-20-15-18(2)4-6-21(20)28-25(24)26(31)33/h4-7,14-16,28H,8-13H2,1-3H3 ODMKORVZKAJKIW-UHFFFAOYSA-N 83407 3-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-8-methyl-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 31 Thiamine pyrophosphokinase 1 1210 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83407 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83407&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4803620 252658603 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124391 Cc1ccc(C)c(N2CCN(C(=O)CCn3cnc4c([nH]c5ccc(C)cc54)c3=O)CC2)c1 InChI=1S/C26H29N5O2/c1-17-5-7-21-20(14-17)24-25(28-21)26(33)31(16-27-24)9-8-23(32)30-12-10-29(11-13-30)22-15-18(2)4-6-19(22)3/h4-7,14-16,28H,8-13H2,1-3H3 NXFHXKHJZZLXFW-UHFFFAOYSA-N 83408 3-(3-oxo-3-(4-(3-(trifluoromethyl)benzyl)piperazin-1-yl)propyl)-8-(trifluoromethyl)-3,5-dihydro-4H-pyrimido[5,4-b]indol-4-one ::US20250388584, Example 34 Thiamine pyrophosphokinase 1 1374 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83408 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83408&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 2447253 252658604 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124392 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cc(Cl)ccc5C)CC4)cnc3c2c1 InChI=1S/C25H26ClN5O2/c1-16-3-6-20-19(13-16)23-24(28-20)25(33)31(15-27-23)8-7-22(32)30-11-9-29(10-12-30)21-14-18(26)5-4-17(21)2/h3-6,13-15,28H,7-12H2,1-2H3 AVTPYMWNQJKQCD-UHFFFAOYSA-N 83409 3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-(3-(3-(trifluoromethyl)phenyl)propyl)propanamide ::US20250388584, Example 42 Thiamine pyrophosphokinase 1 3955 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83409&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4878583 252658605 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124393 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cccc(C)c5C)CC4)cnc3c2c1 InChI=1S/C26H29N5O2/c1-17-7-8-21-20(15-17)24-25(28-21)26(33)31(16-27-24)10-9-23(32)30-13-11-29(12-14-30)22-6-4-5-18(2)19(22)3/h4-8,15-16,28H,9-14H2,1-3H3 YZZHZFLJHCEBBL-UHFFFAOYSA-N 83410 N-(2-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)ethyl)-2-(3-(trifluoromethyl)phenyl)acetamide ::US20250388584, Example 44 Thiamine pyrophosphokinase 1 3298 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83410 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83410&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16326480 252658606 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124394 COc1cccc(N2CCN(C(=O)Cn3cnc4c([nH]c5ccc(C)cc54)c3=O)CC2)c1 InChI=1S/C24H25N5O3/c1-16-6-7-20-19(12-16)22-23(26-20)24(31)29(15-25-22)14-21(30)28-10-8-27(9-11-28)17-4-3-5-18(13-17)32-2/h3-7,12-13,15,26H,8-11,14H2,1-2H3 PMPGFFHGRQWOFK-UHFFFAOYSA-N 83411 3-(6-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-(3-(trifluoromethyl)benzyl)propanamide ::US20250388584, Example 45 Thiamine pyrophosphokinase 1 1223 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83411 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83411&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4587627 252658607 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124395 Cc1ccc2[nH]c3c(=O)n(CCCCN4CCN(c5cccc(C(F)(F)F)c5)CC4)cnc3c2c1 InChI=1S/C26H28F3N5O/c1-18-7-8-22-21(15-18)23-24(31-22)25(35)34(17-30-23)10-3-2-9-32-11-13-33(14-12-32)20-6-4-5-19(16-20)26(27,28)29/h4-8,15-17,31H,2-3,9-14H2,1H3 BBQHXEYVEIIFGD-UHFFFAOYSA-N 83412 3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-(3-(trifluoromethyl)phenethyl)propanamide ::US20250388584, Example 48 Thiamine pyrophosphokinase 1 1060 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83412 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83412&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16260203 252658608 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124396 Cc1ccc2[nH]c3c(=O)n(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)cnc3c2c1 InChI=1S/C24H25Cl2N5O/c1-16-6-7-19-17(14-16)22-23(28-19)24(32)31(15-27-22)9-3-8-29-10-12-30(13-11-29)20-5-2-4-18(25)21(20)26/h2,4-7,14-15,28H,3,8-13H2,1H3 VWFGNRZHRZNHGI-UHFFFAOYSA-N 83413 N-(3-hydroxybenzyl)-3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanamide ::US20250388584, Example 52 Thiamine pyrophosphokinase 1 1276 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83413 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83413&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4830308 252658609 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124397 O=C(CCn1cnc2c([nH]c3ccc(C(F)(F)F)cc32)c1=O)N1CCN(Cc2cccc(C(F)(F)F)c2)CC1 InChI=1S/C26H23F6N5O2/c27-25(28,29)17-3-1-2-16(12-17)14-35-8-10-36(11-9-35)21(38)6-7-37-15-33-22-19-13-18(26(30,31)32)4-5-20(19)34-23(22)24(37)39/h1-5,12-13,15,34H,6-11,14H2 ASQNGSRZFCZZIO-UHFFFAOYSA-N 83414 methyl 3-((3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanamido)methyl)benzoate ::US20250388584, Example 53 Thiamine pyrophosphokinase 1 1582 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83414&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 18574678 252658610 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124398 O=C(CCn1cnc2c([nH]c3ccc(C(F)(F)F)cc32)c1=O)N1CCN(Cc2cc(F)c(F)c(F)c2)CC1 InChI=1S/C25H21F6N5O2/c26-17-9-14(10-18(27)21(17)28)12-34-5-7-35(8-6-34)20(37)3-4-36-13-32-22-16-11-15(25(29,30)31)1-2-19(16)33-23(22)24(36)38/h1-2,9-11,13,33H,3-8,12H2 DOCBQBDJAPQFCP-UHFFFAOYSA-N 83415 3-((3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanamido)methyl)benzamide ::US20250388584, Example 54 Thiamine pyrophosphokinase 1 1679 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83415&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 3319690 252658611 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124399 Cc1ccc2[nH]c3c(=O)n(CC(=O)NCCCN4CCN(Cc5ccccc5)CC4)ncc3c2c1 InChI=1S/C27H32N6O2/c1-20-8-9-24-22(16-20)23-17-29-33(27(35)26(23)30-24)19-25(34)28-10-5-11-31-12-14-32(15-13-31)18-21-6-3-2-4-7-21/h2-4,6-9,16-17,30H,5,10-15,18-19H2,1H3,(H,28,34) IZOHYJDENOVMKJ-UHFFFAOYSA-N 83416 3-((3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanamido)methyl)benzoic Acid ::US20250388584, Example 55 Thiamine pyrophosphokinase 1 10560 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83416&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 3432723 252658612 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124400 Cc1ccc2oc3c(=O)n(CCC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)cnc3c2c1 InChI=1S/C25H23F3N4O3/c1-16-5-6-20-19(13-16)22-23(35-20)24(34)32(15-29-22)8-7-21(33)31-11-9-30(10-12-31)18-4-2-3-17(14-18)25(26,27)28/h2-6,13-15H,7-12H2,1H3 SQCGXSZUYKQNHG-UHFFFAOYSA-N 83418 3-(8-methyl-4-oxobenzofuro[3,2-d]pyrimidin-3(4H)-yl)-N-(3-(trifluoromethyl)benzyl)propanamide ::US20250388584, Example 57 Thiamine pyrophosphokinase 1 1191 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83418&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 18564899 252658614 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124401 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)ccc3c2c1 InChI=1S/C26H25F3N4O2/c1-17-5-6-22-21(15-17)20-7-9-33(25(35)24(20)30-22)10-8-23(34)32-13-11-31(12-14-32)19-4-2-3-18(16-19)26(27,28)29/h2-7,9,15-16,30H,8,10-14H2,1H3 FABVDECBTMYHFJ-UHFFFAOYSA-N 83419 3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-(2-((3-(trifluoromethyl)phenyl)amino)ethyl)propanamide ::US20250388584, Example 59 Thiamine pyrophosphokinase 1 1384 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83419&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 1728158 252658615 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124402 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)cnc3c2c1 InChI=1S/C25H24F3N5O2/c1-16-5-6-20-19(13-16)22-23(30-20)24(35)33(15-29-22)8-7-21(34)32-11-9-31(10-12-32)18-4-2-3-17(14-18)25(26,27)28/h2-6,13-15,30H,7-12H2,1H3 ANROVTQDCBIESA-UHFFFAOYSA-N 83420 N-methyl-3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)-N-(2-((3-(trifluoromethyl)phenyl)amino)ethyl)propanamide ::US20250388584, Example 61 Thiamine pyrophosphokinase 1 1208 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83420 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83420&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 761684 252658616 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124403 Cc1ccc2[nH]c3c(=O)n(CCC(=O)NCc4cccc(C(F)(F)F)c4)ccc3c2c1 InChI=1S/C23H20F3N3O2/c1-14-5-6-19-18(11-14)17-7-9-29(22(31)21(17)28-19)10-8-20(30)27-13-15-3-2-4-16(12-15)23(24,25)26/h2-7,9,11-12,28H,8,10,13H2,1H3,(H,27,30) HACJKMJZYLYIDG-UHFFFAOYSA-N 83421 N-(2-(methyl(5,6,7,8-tetrahydronaphthalen-1-yl)amino)ethyl)-3-(8-methyl-4-oxo-4,5-dihydro-3H-pyrimido[5,4-b]indol-3-yl)propanamide ::US20250388584, Example 67 Thiamine pyrophosphokinase 1 1203 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83421&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 1016249 252658617 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124404 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N(C)CCNc4cccc(C(F)(F)F)c4)cnc3c2c1 InChI=1S/C24H24F3N5O2/c1-15-6-7-19-18(12-15)21-22(30-19)23(34)32(14-29-21)10-8-20(33)31(2)11-9-28-17-5-3-4-16(13-17)24(25,26)27/h3-7,12-14,28,30H,8-11H2,1-2H3 XFQUGZGAZHGRBD-UHFFFAOYSA-N 83422 US20250388584, Example 91 Thiamine pyrophosphokinase 1 3720 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83422&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 2206548 252658618 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124405 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N(C)CCN(C)c4cccc(C(F)(F)F)c4)cnc3c2c1 InChI=1S/C25H26F3N5O2/c1-16-7-8-20-19(13-16)22-23(30-20)24(35)33(15-29-22)10-9-21(34)32(3)12-11-31(2)18-6-4-5-17(14-18)25(26,27)28/h4-8,13-15,30H,9-12H2,1-3H3 GOLDNGWFUPVNIE-UHFFFAOYSA-N 83423 US20250388584, Example 92 Thiamine pyrophosphokinase 1 3555 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83423&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16394140 252658619 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124406 Cc1ccc2[nH]c3c(=O)n(CCC(=O)NCc4cccc(C(F)(F)F)c4)cnc3c2c1 InChI=1S/C22H19F3N4O2/c1-13-5-6-17-16(9-13)19-20(28-17)21(31)29(12-27-19)8-7-18(30)26-11-14-3-2-4-15(10-14)22(23,24)25/h2-6,9-10,12,28H,7-8,11H2,1H3,(H,26,30) HMYXUYFUEFBXHO-UHFFFAOYSA-N 83424 US20250388584, Example 97 Thiamine pyrophosphokinase 1 1007 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83424&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 24891946 252658620 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124407 Cc1ccc2[nH]c3c(=O)n(CCC(=O)NCCNc4cccc5c4CCCC5)cnc3c2c1 InChI=1S/C26H29N5O2/c1-17-9-10-22-20(15-17)24-25(30-22)26(33)31(16-29-24)14-11-23(32)28-13-12-27-21-8-4-6-18-5-2-3-7-19(18)21/h4,6,8-10,15-16,27,30H,2-3,5,7,11-14H2,1H3,(H,28,32) FKIUFXGDWHKFFQ-UHFFFAOYSA-N 83425 US20250388584, Example 129 Thiamine pyrophosphokinase 1 1165 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83425&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 24892009 252658621 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124408 Cc1ccc2[nH]c3c(=O)n(CCC(=O)NCCN(C)c4cccc5c4CCCC5)cnc3c2c1 InChI=1S/C27H31N5O2/c1-18-10-11-22-21(16-18)25-26(30-22)27(34)32(17-29-25)14-12-24(33)28-13-15-31(2)23-9-5-7-19-6-3-4-8-20(19)23/h5,7,9-11,16-17,30H,3-4,6,8,12-15H2,1-2H3,(H,28,33) CADWIJCWMHGWOC-UHFFFAOYSA-N 83426 US20250388584, Example 130 Thiamine pyrophosphokinase 1 1358 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83426 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83426&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 24892062 252658622 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124409 Cc1ccc2nc3c(=O)n(CCC(=O)N4CCN(c5cccc(C(F)(F)F)c5)CC4)cnc3cc2c1 InChI=1S/C26H24F3N5O2/c1-17-5-6-21-18(13-17)14-22-24(31-21)25(36)34(16-30-22)8-7-23(35)33-11-9-32(10-12-33)20-4-2-3-19(15-20)26(27,28)29/h2-6,13-16H,7-12H2,1H3 FZUMWEXWCYPPSO-UHFFFAOYSA-N 83427 US20250388584, Example 138 Thiamine pyrophosphokinase 1 1162 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83427&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 24892091 252658623 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124410 COc1ccc2c(c1)N1CCN(c3ccccc3OC)CC1C(C(=O)NCCN1CCCCC1)C2 InChI=1S/C28H38N4O3/c1-34-22-11-10-21-18-23(28(33)29-12-15-30-13-6-3-7-14-30)26-20-31(16-17-32(26)25(21)19-22)24-8-4-5-9-27(24)35-2/h4-5,8-11,19,23,26H,3,6-7,12-18,20H2,1-2H3,(H,29,33) TWSVHWWJMCJPKO-UHFFFAOYSA-N 83428 US20250388584, Example 139 Thiamine pyrophosphokinase 1 950 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83428&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 91898503 252658624 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124411 O=C(N[C@@H](Cc1ccc(F)cc1)C(=O)O)OCC1c2ccccc2-c2ccccc21 InChI=1S/C24H20FNO4/c25-16-11-9-15(10-12-16)13-22(23(27)28)26-24(29)30-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,26,29)(H,27,28) IXUMACXMEZBPJG-UHFFFAOYSA-N 83429 US20250388584, Example 141 Thiamine pyrophosphokinase 1 4069 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83429 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83429&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 24892695 252658625 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124412 C[C@H](OC(C)(C)C)[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O InChI=1S/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26) LZOLWEQBVPVDPR-UHFFFAOYSA-N 83430 US20250388584, Example 142 Thiamine pyrophosphokinase 1 9044 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83430 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83430&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 17540413 252658626 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124413 O=C(CCn1cnc2c(sc3ccccc32)c1=O)N1CCN(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C24H21F3N4O2S/c25-24(26,27)16-4-3-5-17(14-16)29-10-12-30(13-11-29)20(32)8-9-31-15-28-21-18-6-1-2-7-19(18)34-22(21)23(31)33/h1-7,14-15H,8-13H2 TYIQIROHEDZKGO-UHFFFAOYSA-N 83431 US20250388584, Example 144 Thiamine pyrophosphokinase 1 1956 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83431 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83431&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 24687019 252658627 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124414 O=C(CCn1cnc2c(sc3ccccc32)c1=O)N1CCC(Cc2ccc(F)cc2)CC1 InChI=1S/C25H24FN3O2S/c26-19-7-5-17(6-8-19)15-18-9-12-28(13-10-18)22(30)11-14-29-16-27-23-20-3-1-2-4-21(20)32-24(23)25(29)31/h1-8,16,18H,9-15H2 WZIKIPZSALYVEO-UHFFFAOYSA-N 83432 US20250388584, Example 146 Thiamine pyrophosphokinase 1 1908 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83432&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16302261 252658628 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124415 O=C(CCn1cnc2c(sc3ccccc32)c1=O)N1CCC(O)(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C25H22F3N3O3S/c26-25(27,28)17-5-3-4-16(14-17)24(34)9-12-30(13-10-24)20(32)8-11-31-15-29-21-18-6-1-2-7-19(18)35-22(21)23(31)33/h1-7,14-15,34H,8-13H2 FPROVDJSHDQXEQ-UHFFFAOYSA-N 83433 US20250388584, Example 147 Thiamine pyrophosphokinase 1 7716 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83433 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83433&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 24982438 252658629 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124416 O=C(CCn1cnc2c(oc3ccc(F)cc32)c1=O)N1CCN(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C24H20F4N4O3/c25-16-4-5-19-18(13-16)21-22(35-19)23(34)32(14-29-21)7-6-20(33)31-10-8-30(9-11-31)17-3-1-2-15(12-17)24(26,27)28/h1-5,12-14H,6-11H2 NYRFCBZHUBGZPC-UHFFFAOYSA-N 83437 US20250388584, Example 148 Thiamine pyrophosphokinase 1 1987 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83437 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83437&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 25162458 252658632 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124417 O=C(CCn1cnc2c(oc3ccc(F)cc32)c1=O)N1CCC(Cc2ccc(F)cc2)CC1 InChI=1S/C25H23F2N3O3/c26-18-3-1-16(2-4-18)13-17-7-10-29(11-8-17)22(31)9-12-30-15-28-23-20-14-19(27)5-6-21(20)33-24(23)25(30)32/h1-6,14-15,17H,7-13H2 HLPPXNWMSIRLPS-UHFFFAOYSA-N 83438 US20250388584, Example 150 Thiamine pyrophosphokinase 1 1990 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83438 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83438&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 9504185 252658633 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124418 O=C(CCn1cnc2c(oc3ccc(F)cc32)c1=O)N1CCC(O)(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C25H21F4N3O4/c26-17-4-5-19-18(13-17)21-22(36-19)23(34)32(14-30-21)9-6-20(33)31-10-7-24(35,8-11-31)15-2-1-3-16(12-15)25(27,28)29/h1-5,12-14,35H,6-11H2 ZALKSFZJVHSULO-UHFFFAOYSA-N 83439 US20250388584, Example 151 Thiamine pyrophosphokinase 1 5983 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83439 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83439&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4018333 252658634 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124419 O=C(CCn1cnc2c([nH]c3ccc(F)cc32)c1=O)N1CCN(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C24H21F4N5O2/c25-16-4-5-19-18(13-16)21-22(30-19)23(35)33(14-29-21)7-6-20(34)32-10-8-31(9-11-32)17-3-1-2-15(12-17)24(26,27)28/h1-5,12-14,30H,6-11H2 COABQMMBTFVDEY-UHFFFAOYSA-N 83440 US20250388584, Example 153 Thiamine pyrophosphokinase 1 3170 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83440 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83440&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 3983975 252658635 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124420 O=C(CCn1cnc2c([nH]c3ccc(F)cc32)c1=O)N1CCC(Cc2ccc(F)cc2)CC1 InChI=1S/C25H24F2N4O2/c26-18-3-1-16(2-4-18)13-17-7-10-30(11-8-17)22(32)9-12-31-15-28-23-20-14-19(27)5-6-21(20)29-24(23)25(31)33/h1-6,14-15,17,29H,7-13H2 ZAFOJTRUNOFIFX-UHFFFAOYSA-N 83441 US20250388584, Example 154 Thiamine pyrophosphokinase 1 2600 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83441 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83441&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4973873 252658636 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124421 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCC(Cc5ccc(F)cc5)CC4)cnc3c2c1 InChI=1S/C26H27FN4O2/c1-17-2-7-22-21(14-17)24-25(29-22)26(33)31(16-28-24)13-10-23(32)30-11-8-19(9-12-30)15-18-3-5-20(27)6-4-18/h2-7,14,16,19,29H,8-13,15H2,1H3 KCSYECDXSIIOAB-UHFFFAOYSA-N 83442 US20250388584, Example 164 Thiamine pyrophosphokinase 1 2320 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83442 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83442&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 25163156 252658637 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124422 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCC(O)(c5cccc(C(F)(F)F)c5)CC4)cnc3c2c1 InChI=1S/C26H25F3N4O3/c1-16-5-6-20-19(13-16)22-23(31-20)24(35)33(15-30-22)10-7-21(34)32-11-8-25(36,9-12-32)17-3-2-4-18(14-17)26(27,28)29/h2-6,13-15,31,36H,7-12H2,1H3 BVXMVTXDFCJTMT-UHFFFAOYSA-N 83443 US20250388584, Example 165 Thiamine pyrophosphokinase 1 2490 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83443 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83443&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 44142946 252658638 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124423 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCC(N(C)c5cccc(Cl)c5Cl)CC4)cnc3c2c1 InChI=1S/C26H27Cl2N5O2/c1-16-6-7-20-18(14-16)24-25(30-20)26(35)33(15-29-24)13-10-22(34)32-11-8-17(9-12-32)31(2)21-5-3-4-19(27)23(21)28/h3-7,14-15,17,30H,8-13H2,1-2H3 BYVSTJBRQLIGKK-UHFFFAOYSA-N 83444 US20250388584, Example 166 Thiamine pyrophosphokinase 1 495 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83444 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83444&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4885015 252658639 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124424 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5ccc(S(=O)(=O)N6CCCCC6)cc5)CC4)cnc3c2c1 InChI=1S/C29H34N6O4S/c1-21-5-10-25-24(19-21)27-28(31-25)29(37)34(20-30-27)14-11-26(36)33-17-15-32(16-18-33)22-6-8-23(9-7-22)40(38,39)35-12-3-2-4-13-35/h5-10,19-20,31H,2-4,11-18H2,1H3 LYPSJXCJLZSDRQ-UHFFFAOYSA-N 83445 US20250388584, Example 169 Thiamine pyrophosphokinase 1 2144 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83445 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83445&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 44201929 252658640 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124425 Cc1ccc2[nH]c3c(=O)n(CCC(=O)N4CCN(c5cccc(S(=O)(=O)N6CCCCC6)c5)CC4)cnc3c2c1 InChI=1S/C29H34N6O4S/c1-21-8-9-25-24(18-21)27-28(31-25)29(37)34(20-30-27)13-10-26(36)33-16-14-32(15-17-33)22-6-5-7-23(19-22)40(38,39)35-11-3-2-4-12-35/h5-9,18-20,31H,2-4,10-17H2,1H3 NCXBQVFGXHJLJE-UHFFFAOYSA-N 83446 US20250388584, Example 170 Thiamine pyrophosphokinase 1 2370 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83446 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83446&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 16312302 252658641 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124426 O=C1CCCCN1CCCN1c2ccccc2Sc2ccccc21 InChI=1S/C20H22N2OS/c23-20-12-5-6-13-21(20)14-7-15-22-16-8-1-3-10-18(16)24-19-11-4-2-9-17(19)22/h1-4,8-11H,5-7,12-15H2 XHRCRGYAYMMFPP-UHFFFAOYSA-N 83447 US20250388584, Example 186 Thiamine pyrophosphokinase 1 2660 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83447 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83447&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 2447421 252658642 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124427 O=C1CCCCN1CCCCCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21 InChI=1S/C24H27F3N2OS/c25-24(26,27)18-12-13-22-20(17-18)29(19-9-3-4-10-21(19)31-22)16-7-2-1-6-14-28-15-8-5-11-23(28)30/h3-4,9-10,12-13,17H,1-2,5-8,11,14-16H2 MECSUEOZQSRMDK-UHFFFAOYSA-N 83448 US20250388584, Example 187 Thiamine pyrophosphokinase 1 1132 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83448 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83448&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 44246524 242053758 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124428 O=C1c2ccccc2CN1CCCN1c2ccccc2Sc2ccccc21 InChI=1S/C23H20N2OS/c26-23-18-9-2-1-8-17(18)16-24(23)14-7-15-25-19-10-3-5-12-21(19)27-22-13-6-4-11-20(22)25/h1-6,8-13H,7,14-16H2 OGRPLUFGWGRNGP-UHFFFAOYSA-N 83451 US20250388584, Example 189 Thiamine pyrophosphokinase 1 1201 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83451 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83451&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 5464087 252658645 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124429 O=C1Cc2ccc(OCCCN3c4ccccc4Sc4ccccc43)cc2N1 InChI=1S/C23H20N2O2S/c26-23-14-16-10-11-17(15-18(16)24-23)27-13-5-12-25-19-6-1-3-8-21(19)28-22-9-4-2-7-20(22)25/h1-4,6-11,15H,5,12-14H2,(H,24,26) XQCUTUBFEBDYFO-UHFFFAOYSA-N 83452 US20250388584, Example 190 Thiamine pyrophosphokinase 1 1107 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83452&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 25137868 252658646 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124430 COC(=O)C1CCCCN1CCCN1c2ccccc2Sc2ccccc21 InChI=1S/C22H26N2O2S/c1-26-22(25)19-11-6-7-14-23(19)15-8-16-24-17-9-2-4-12-20(17)27-21-13-5-3-10-18(21)24/h2-5,9-10,12-13,19H,6-8,11,14-16H2,1H3 KXESMQZDFQKGCM-UHFFFAOYSA-N 83453 US20250388584, Example 191 Thiamine pyrophosphokinase 1 5600 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83453&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 5311353 242053759 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124431 O=C1CCCCN1CCCCCCN1CCSc2ccc(C(F)(F)F)cc21 InChI=1S/C20H27F3N2OS/c21-20(22,23)16-8-9-18-17(15-16)24(13-14-27-18)10-4-1-2-5-11-25-12-6-3-7-19(25)26/h8-9,15H,1-7,10-14H2 YHGHEPRDGMAUGA-UHFFFAOYSA-N 83455 US20250388584, Example 193 Thiamine pyrophosphokinase 1 7487 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83455 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83455&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 2999792 252658648 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124432 OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1 InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2 PLDUPXSUYLZYBN-UHFFFAOYSA-N 78433 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol;hydrochloride::SMR000058411::FLUPHENAZINE::cid_3372::FLUPHENAZINE HYDROCHLORIDE::MLS001076508::2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]propyl]-1-piperazinyl]ethanol;hydrochloride::cid_6602611::2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazino]ethanol;hydrochloride::med.21724, Compound 17::US20250388584, Example 198 Thiamine pyrophosphokinase 1 3366 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=78433 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=78433&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 3372 252655189 DB00623 C07010 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124433 O=C(O)CCC(=O)OCCN1CCN(CCC(=O)N2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1 InChI=1S/C26H28F3N3O5S/c27-26(28,29)18-5-6-22-20(17-18)32(19-3-1-2-4-21(19)38-22)23(33)9-10-30-11-13-31(14-12-30)15-16-37-25(36)8-7-24(34)35/h1-6,17H,7-16H2,(H,34,35) RTXVCIPJNLSCLI-UHFFFAOYSA-N 83459 US20250388584, Example 199 Thiamine pyrophosphokinase 1 490 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83459&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 45281074 252658650 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124434 O=C(CCN1c2ccccc2Sc2ccccc21)NCCN1CCOCC1 InChI=1S/C21H25N3O2S/c25-21(22-10-12-23-13-15-26-16-14-23)9-11-24-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)24/h1-8H,9-16H2,(H,22,25) PARYJUPISCKSHU-UHFFFAOYSA-N 83460 US20250388584, Example 200 Thiamine pyrophosphokinase 1 2.94 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83460&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 376180 252658651 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124435 O=C1CCc2ccc(OCCCCN3c4ccccc4Sc4ccc(C(F)(F)F)cc43)cc2N1 InChI=1S/C26H23F3N2O2S/c27-26(28,29)18-9-11-24-22(15-18)31(21-5-1-2-6-23(21)34-24)13-3-4-14-33-19-10-7-17-8-12-25(32)30-20(17)16-19/h1-2,5-7,9-11,15-16H,3-4,8,12-14H2,(H,30,32) ZTYBTPCGKRORLD-UHFFFAOYSA-N 83462 US20250388584, Example 204 Thiamine pyrophosphokinase 1 107 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83462&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 384401 252658653 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124436 O=C1CCc2ccc(OCCCCCN3c4ccccc4Sc4ccc(C(F)(F)F)cc43)cc2N1 InChI=1S/C27H25F3N2O2S/c28-27(29,30)19-10-12-25-23(16-19)32(22-6-2-3-7-24(22)35-25)14-4-1-5-15-34-20-11-8-18-9-13-26(33)31-21(18)17-20/h2-3,6-8,10-12,16-17H,1,4-5,9,13-15H2,(H,31,33) RVHIAOAJMYIKKR-UHFFFAOYSA-N 83463 US20250388584, Example 206 Thiamine pyrophosphokinase 1 1453 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83463&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 45479834 242053760 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124437 COc1ccc2[nH]c(=O)c3c(ccn3CCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)c2c1 InChI=1S/C26H27F3N4O2/c1-35-20-6-7-23-22(17-20)21-8-11-33(24(21)25(34)30-23)10-3-9-31-12-14-32(15-13-31)19-5-2-4-18(16-19)26(27,28)29/h2,4-8,11,16-17H,3,9-10,12-15H2,1H3,(H,30,34) CTZMASSGTVOBMR-UHFFFAOYSA-N 83464 US20250388584, Example 210 Thiamine pyrophosphokinase 1 1800 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83464 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83464&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 4749 252658654 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124438 Cc1ccc2c(c1)-c1nc(=O)n(CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc1CO2 InChI=1S/C25H26Cl2N4O2/c1-17-6-7-22-19(14-17)24-18(16-33-22)15-31(25(32)28-24)9-3-8-29-10-12-30(13-11-29)21-5-2-4-20(26)23(21)27/h2,4-7,14-15H,3,8-13,16H2,1H3 ZTOHKZMQUXRSBR-UHFFFAOYSA-N 83465 US20250388584, Example 213 Thiamine pyrophosphokinase 1 546 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83465 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83465&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 276192 252658655 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124439 Cc1ccc2c(c1)-c1nc(=O)n(CCC(=O)N3CCN(c4cccc(Cl)c4Cl)CC3)cc1CO2 InChI=1S/C25H24Cl2N4O3/c1-16-5-6-21-18(13-16)24-17(15-34-21)14-31(25(33)28-24)8-7-22(32)30-11-9-29(10-12-30)20-4-2-3-19(26)23(20)27/h2-6,13-14H,7-12,15H2,1H3 BLISHWOZWYNEJF-UHFFFAOYSA-N 83724 US20250388584, Example 214 Thiamine pyrophosphokinase 1 2376 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83724 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83724&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 651471 252658908 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124440 Cc1ccc2c(c1)-c1ncn(CCC(=O)N3CCN(c4cccc(C(F)(F)F)c4)CC3)c(=O)c1CC2 InChI=1S/C27H27F3N4O2/c1-18-5-6-19-7-8-22-25(23(19)15-18)31-17-34(26(22)36)10-9-24(35)33-13-11-32(12-14-33)21-4-2-3-20(16-21)27(28,29)30/h2-6,15-17H,7-14H2,1H3 JUIXJWZWEAKXPJ-UHFFFAOYSA-N 83725 US20250388584, Example 215 Thiamine pyrophosphokinase 1 1126 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83725&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 654651 252658909 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124441 Cc1ccc2ncc3c(=O)n(CCCC(=O)N4CCN(c5cccc(Cl)c5Cl)CC4)cnc3c2c1 InChI=1S/C26H25Cl2N5O2/c1-17-7-8-21-18(14-17)25-19(15-29-21)26(35)33(16-30-25)9-3-6-23(34)32-12-10-31(11-13-32)22-5-2-4-20(27)24(22)28/h2,4-5,7-8,14-16H,3,6,9-13H2,1H3 HGDCHFALFXHFGG-UHFFFAOYSA-N 83727 US20250388584, Example 217 Thiamine pyrophosphokinase 1 1470 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83727&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 655538 252658911 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124442 Cc1ccc2ncc3c(=O)n(CCCC(=O)N4CCC(Cc5ccc(F)cc5)CC4)cnc3c2c1 InChI=1S/C28H29FN4O2/c1-19-4-9-25-23(15-19)27-24(17-30-25)28(35)33(18-31-27)12-2-3-26(34)32-13-10-21(11-14-32)16-20-5-7-22(29)8-6-20/h4-9,15,17-18,21H,2-3,10-14,16H2,1H3 GKYIKSNDPHVSGI-UHFFFAOYSA-N 83728 US20250388584, Example 218 Thiamine pyrophosphokinase 1 617 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83728&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 5389171 252658912 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124443 Cc1ccc2c(c1)-c1nc(=O)n(CCCC(=O)N3CCC(Cc4ccc(F)cc4)CC3)cc1CO2 InChI=1S/C28H30FN3O3/c1-19-4-9-25-24(15-19)27-22(18-35-25)17-32(28(34)30-27)12-2-3-26(33)31-13-10-21(11-14-31)16-20-5-7-23(29)8-6-20/h4-9,15,17,21H,2-3,10-14,16,18H2,1H3 DXUUZIODPGBYSN-UHFFFAOYSA-N 83729 US20250388584, Example 220 Thiamine pyrophosphokinase 1 3886 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83729&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 659787 242053771 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124444 O=C(CCn1cnc2c(c1=O)CCCc1ccccc1-2)N1CCN(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C27H27F3N4O2/c28-27(29,30)20-7-4-8-21(17-20)32-13-15-33(16-14-32)24(35)11-12-34-18-31-25-22-9-2-1-5-19(22)6-3-10-23(25)26(34)36/h1-2,4-5,7-9,17-18H,3,6,10-16H2 GNAFGPZXDACSIB-UHFFFAOYSA-N 83730 US20250388584, Example 221 Thiamine pyrophosphokinase 1 1650 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83730&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 7082531 252658913 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124445 O=c1c2c(ncn1CCCN1CCN(c3cccc(Cl)c3Cl)CC1)-c1ccccc1CCC2 InChI=1S/C26H28Cl2N4O/c27-22-10-4-11-23(24(22)28)31-16-14-30(15-17-31)12-5-13-32-18-29-25-20-8-2-1-6-19(20)7-3-9-21(25)26(32)33/h1-2,4,6,8,10-11,18H,3,5,7,9,12-17H2 HKJHSGMEIXZVKX-UHFFFAOYSA-N 83731 US20250388584, Example 222 Thiamine pyrophosphokinase 1 500 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83731&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 662408 252658914 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124446 Cc1ccc2ncc3c(=O)n(CCCC(=O)N4CCC(Cc5ccc(F)cc5)CC4)cnc3c2c1 InChI=1S/C28H29FN4O2/c1-19-4-9-25-23(15-19)27-24(17-30-25)28(35)33(18-31-27)12-2-3-26(34)32-13-10-21(11-14-32)16-20-5-7-22(29)8-6-20/h4-9,15,17-18,21H,2-3,10-14,16H2,1H3 GKYIKSNDPHVSGI-UHFFFAOYSA-N 83732 US20250388584, Example 223 Thiamine pyrophosphokinase 1 1330 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83732&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 663173 252658915 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124447 Cc1ccc2c(c1)-c1ncn(CCC(=O)N3CCC(Cc4ccc(F)cc4)CC3)c(=O)c1CC2 InChI=1S/C28H30FN3O2/c1-19-2-5-22-6-9-24-27(25(22)16-19)30-18-32(28(24)34)15-12-26(33)31-13-10-21(11-14-31)17-20-3-7-23(29)8-4-20/h2-5,7-8,16,18,21H,6,9-15,17H2,1H3 VMGYXMHVGNIUFU-UHFFFAOYSA-N 83733 US20250388584, Example 225 Thiamine pyrophosphokinase 1 930 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83733&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 663341 252658916 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124448 O=C(CCCn1cnc2c(c1=O)CCCc1ccccc1-2)N1CCN(c2cccc(C(F)(F)F)c2)CC1 InChI=1S/C28H29F3N4O2/c29-28(30,31)21-8-4-9-22(18-21)33-14-16-34(17-15-33)25(36)12-5-13-35-19-32-26-23-10-2-1-6-20(23)7-3-11-24(26)27(35)37/h1-2,4,6,8-10,18-19H,3,5,7,11-17H2 WZFUVJONJKNGOL-UHFFFAOYSA-N 83734 US20250388584, Example 228 Thiamine pyrophosphokinase 1 2134 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83734&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 663658 252658917 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124449 COc1ccc2[nH]c(=O)c3c(ncn3CCCC(=O)N3CCN(c4cccc(Cl)c4Cl)CC3)c2c1 InChI=1S/C25H25Cl2N5O3/c1-35-16-7-8-19-17(14-16)23-24(25(34)29-19)32(15-28-23)9-3-6-21(33)31-12-10-30(11-13-31)20-5-2-4-18(26)22(20)27/h2,4-5,7-8,14-15H,3,6,9-13H2,1H3,(H,29,34) GZTBLSJMJKUZSE-UHFFFAOYSA-N 83735 US20250388584, Example 231 Thiamine pyrophosphokinase 1 2262 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83735&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 664720 242053772 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124450 Cc1ccc2c(c1)N1CCCC(C(=O)NCCCN3CCN(c4cccc(C(F)(F)F)c4)CC3)C1CO2 InChI=1S/C28H35F3N4O2/c1-20-8-9-26-24(17-20)35-12-3-7-23(25(35)19-37-26)27(36)32-10-4-11-33-13-15-34(16-14-33)22-6-2-5-21(18-22)28(29,30)31/h2,5-6,8-9,17-18,23,25H,3-4,7,10-16,19H2,1H3,(H,32,36) SJZLSBBJVBOCMO-UHFFFAOYSA-N 83736 US20250388584, Example 232 Thiamine pyrophosphokinase 1 1812 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83736&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 5389982 252658918 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602 124451 COc1ccc2[nH]c(=O)c3c(c2c1)CN(CCCN1CCN(c2cccc(C)c2Cl)CC1)C3 InChI=1S/C26H31ClN4O2/c1-18-5-3-6-24(25(18)27)31-13-11-29(12-14-31)9-4-10-30-16-21-20-15-19(33-2)7-8-23(20)28-26(32)22(21)17-30/h3,5-8,15H,4,9-14,16-17H2,1-2H3,(H,28,32) GPBLLJOGPHHAHN-UHFFFAOYSA-N 83737 US20250388584, Example 235 Thiamine pyrophosphokinase 1 572 US Patent 10.7270/Q23B64X1 US20250388584 MENG, L; JING, H; ZHANG, H 12/25/2025 5/6/2026 Shanghai Raising Pharmaceutical Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=83737 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2086&target=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=83737&enzyme=Thiamine+pyrophosphokinase+1&column=ki&startPg=0&Increment=50&submit=Search 3236206 252658919 1 MEHAFTPLEPLLSTGNLKYCLVILNQPLDNYFRHLWNKALLRACADGGANRLYDITEGERESFLPEFINGDFDSIRPEVREYYATKGCELISTPDQDHTDFTKCLKMLQKKIEEKDLKVDVIVTLGGLAGRFDQIMASVNTLFQATHITPFPIIIIQEESLIYLLQPGKHRLHVDTGMEGDWCGLIPVGQPCMQVTTTGLKWNLTNDVLAFGTLVSTSNTYDGSGVVTVETDHPLLWTMAIKS 9HJC,3S4Y Thiamine pyrophosphokinase 1 TPK1_HUMAN Q9H3S4 A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H602