BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
129998	O=C(N[C@H]1COCc2c1cnn2-c1ccccc1F)c1ncn2c1CCCC2	InChI=1S/C20H20FN5O2/c21-14-5-1-2-6-16(14)26-18-11-28-10-15(13(18)9-23-26)24-20(27)19-17-7-3-4-8-25(17)12-22-19/h1-2,5-6,9,12,15H,3-4,7-8,10-11H2,(H,24,27)	RJISFAFJOAATHP-UHFFFAOYSA-N	95590	US20250388602, Example 2	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 5500							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95590	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95590&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4900820	164036834							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
129999	O=C(N[C@@H]1COCc2c1cnn2-c1ccccc1F)c1ncn2c1CCCC2	InChI=1S/C20H20FN5O2/c21-14-5-1-2-6-16(14)26-18-11-28-10-15(13(18)9-23-26)24-20(27)19-17-7-3-4-8-25(17)12-22-19/h1-2,5-6,9,12,15H,3-4,7-8,10-11H2,(H,24,27)	RJISFAFJOAATHP-UHFFFAOYSA-N	95591	US20250388602, Example 3	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95591	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95591&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			1769385	164036835							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130000	O=C(N[C@H]1COCc2c1cnn2-c1ccccc1F)c1ncc2n1CCCC2	InChI=1S/C20H20FN5O2/c21-15-6-1-2-7-17(15)26-18-12-28-11-16(14(18)10-23-26)24-20(27)19-22-9-13-5-3-4-8-25(13)19/h1-2,6-7,9-10,16H,3-5,8,11-12H2,(H,24,27)	NUACERWOAHVMJI-UHFFFAOYSA-N	95592	US20250388602, Example 5	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 5500							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95592	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95592&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			8069390	164036836							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130001	O=C(N[C@@H]1COCc2c1cnn2-c1ccccc1F)c1ncc2n1CCCC2	InChI=1S/C20H20FN5O2/c21-15-6-1-2-7-17(15)26-18-12-28-11-16(14(18)10-23-26)24-20(27)19-22-9-13-5-3-4-8-25(13)19/h1-2,6-7,9-10,16H,3-5,8,11-12H2,(H,24,27)	NUACERWOAHVMJI-UHFFFAOYSA-N	95593	US20250388602, Example 6	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95593	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95593&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4908491	164036837							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130002	COc1ccc(F)c(-n2ncc3c2COC[C@@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95594	US20250388602, Example 8	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95594	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95594&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4910060	164036838							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130003	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130004	O=C(N[C@H]1COCc2c1cnn2-c1c(F)cccc1Cl)c1ncn2c1CCCC2	InChI=1S/C20H19ClFN5O2/c21-13-4-3-5-14(22)19(13)27-17-10-29-9-15(12(17)8-24-27)25-20(28)18-16-6-1-2-7-26(16)11-23-18/h3-5,8,11,15H,1-2,6-7,9-10H2,(H,25,28)	PSPVSBREKKTAML-UHFFFAOYSA-N	95596	US20250388602, Example 10	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95596	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95596&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7951074	164036840							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130005	O=C(N[C@@H]1COCc2c1cnn2-c1c(F)cccc1Cl)c1ncn2c1CCCC2	InChI=1S/C20H19ClFN5O2/c21-13-4-3-5-14(22)19(13)27-17-10-29-9-15(12(17)8-24-27)25-20(28)18-16-6-1-2-7-26(16)11-23-18/h3-5,8,11,15H,1-2,6-7,9-10H2,(H,25,28)	PSPVSBREKKTAML-UHFFFAOYSA-N	95597	US20250388602, Example 11	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95597	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95597&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			8384995	164036841							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130006	O=C(N[C@H]1COCc2c1cnn2-c1c(Cl)cccc1Cl)c1ncn2c1CCCC2	InChI=1S/C20H19Cl2N5O2/c21-13-4-3-5-14(22)19(13)27-17-10-29-9-15(12(17)8-24-27)25-20(28)18-16-6-1-2-7-26(16)11-23-18/h3-5,8,11,15H,1-2,6-7,9-10H2,(H,25,28)	ZZUNZIOFTTZGFV-UHFFFAOYSA-N	95598	US20250388602, Example 12	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95598	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95598&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4902298	164036842							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130007	O=C(N[C@@H]1COCc2c1cnn2-c1c(Cl)cccc1Cl)c1ncn2c1CCCC2	InChI=1S/C20H19Cl2N5O2/c21-13-4-3-5-14(22)19(13)27-17-10-29-9-15(12(17)8-24-27)25-20(28)18-16-6-1-2-7-26(16)11-23-18/h3-5,8,11,15H,1-2,6-7,9-10H2,(H,25,28)	ZZUNZIOFTTZGFV-UHFFFAOYSA-N	95599	US20250388602, Example 13	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95599	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95599&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4975212	164036843							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130008	Cc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H22ClN5O2/c1-13-5-4-7-16(19(13)22)27-18-11-29-10-15(14(18)9-24-27)25-21(28)20-17-6-2-3-8-26(17)12-23-20/h4-5,7,9,12,15H,2-3,6,8,10-11H2,1H3,(H,25,28)	KQHPKERQYXVTFH-UHFFFAOYSA-N	95600	US20250388602, Example 14	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95600	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95600&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4904346	164036844							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130009	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2cccc(C)c2Cl)ncn1C	InChI=1S/C20H22ClN5O2/c1-4-15-19(22-11-25(15)3)20(27)24-14-9-28-10-17-13(14)8-23-26(17)16-7-5-6-12(2)18(16)21/h5-8,11,14H,4,9-10H2,1-3H3,(H,24,27)	HZBNPBLSRKIRLB-UHFFFAOYSA-N	95601	US20250388602, Example 15	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95601	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95601&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4905846	164036845							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130010	Cc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncc3n2CCCC3)c1Cl	InChI=1S/C21H22ClN5O2/c1-13-5-4-7-17(19(13)22)27-18-12-29-11-16(15(18)10-24-27)25-21(28)20-23-9-14-6-2-3-8-26(14)20/h4-5,7,9-10,16H,2-3,6,8,11-12H2,1H3,(H,25,28)	WSFRIMUQJXYXNX-UHFFFAOYSA-N	95602	US20250388602, Example 16	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95602	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95602&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4900490	164036846							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130011	Cc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2n[nH]c3c2CCCC3)c1Cl	InChI=1S/C21H22ClN5O2/c1-12-5-4-8-17(19(12)22)27-18-11-29-10-16(14(18)9-23-27)24-21(28)20-13-6-2-3-7-15(13)25-26-20/h4-5,8-9,16H,2-3,6-7,10-11H2,1H3,(H,24,28)(H,25,26)	UOYIQMDZNURPLD-UHFFFAOYSA-N	95603	US20250388602, Example 17	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95603	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95603&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4900419	164036847							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130012	Cc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2noc3c2CCCC3)c1Cl	InChI=1S/C21H21ClN4O3/c1-12-5-4-7-16(19(12)22)26-17-11-28-10-15(14(17)9-23-26)24-21(27)20-13-6-2-3-8-18(13)29-25-20/h4-5,7,9,15H,2-3,6,8,10-11H2,1H3,(H,24,27)	ZZFUICKXCIIDCE-UHFFFAOYSA-N	95604	US20250388602, Example 18	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95604	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95604&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			16807621	164036848							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130013	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2cccc(C)c2Cl)n[nH]c1C	InChI=1S/C20H22ClN5O2/c1-4-13-12(3)24-25-19(13)20(27)23-15-9-28-10-17-14(15)8-22-26(17)16-7-5-6-11(2)18(16)21/h5-8,15H,4,9-10H2,1-3H3,(H,23,27)(H,24,25)	USOLTHYADBQDBU-UHFFFAOYSA-N	95605	US20250388602, Example 19	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95605	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95605&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			78497020	164036849							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130014	Cc1cnc(C(=O)N[C@@H]2COCc3c2cnn3-c2cccc(C)c2Cl)cc1C	InChI=1S/C21H21ClN4O2/c1-12-5-4-6-18(20(12)22)26-19-11-28-10-17(15(19)9-24-26)25-21(27)16-7-13(2)14(3)8-23-16/h4-9,17H,10-11H2,1-3H3,(H,25,27)	GXYLPMMACAFBGU-UHFFFAOYSA-N	95606	US20250388602, Example 20	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95606	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95606&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7502918	164036850							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130015	COc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H22ClN5O3/c1-29-18-7-4-6-15(19(18)22)27-17-11-30-10-14(13(17)9-24-27)25-21(28)20-16-5-2-3-8-26(16)12-23-20/h4,6-7,9,12,14H,2-3,5,8,10-11H2,1H3,(H,25,28)	OSBCHUPQGYCZOS-UHFFFAOYSA-N	95607	US20250388602, Example 21	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95607	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95607&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			18573966	164036851							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130016	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2cccc(OC)c2Cl)ncn1C	InChI=1S/C20H22ClN5O3/c1-4-14-19(22-11-25(14)2)20(27)24-13-9-29-10-16-12(13)8-23-26(16)15-6-5-7-17(28-3)18(15)21/h5-8,11,13H,4,9-10H2,1-3H3,(H,24,27)	BTGRUMYRPVHPOJ-UHFFFAOYSA-N	95608	US20250388602, Example 22	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95608	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95608&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			18579402	164036852							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130017	COc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H22ClN5O3/c1-29-18-7-4-6-15(19(18)22)27-17-11-30-10-14(13(17)9-24-27)25-21(28)20-16-5-2-3-8-26(16)12-23-20/h4,6-7,9,12,14H,2-3,5,8,10-11H2,1H3,(H,25,28)	OSBCHUPQGYCZOS-UHFFFAOYSA-N	95609	US20250388602, Example 23	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95609	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95609&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7259446	164036853							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130018	COc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2nnn3c2CCCC3)c1Cl	InChI=1S/C20H21ClN6O3/c1-29-17-7-4-6-14(18(17)21)27-16-11-30-10-13(12(16)9-22-27)23-20(28)19-15-5-2-3-8-26(15)25-24-19/h4,6-7,9,13H,2-3,5,8,10-11H2,1H3,(H,23,28)	MWGQEGYGPRTCLO-UHFFFAOYSA-N	95610	US20250388602, Example 24	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95610	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95610&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			8483165	164036854							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130019	COc1cccc(-n2ncc3c2COC[C@H]3NC(=O)C2=NON3CCCCC23)c1Cl	InChI=1S/C20H22ClN5O4/c1-28-17-7-4-6-14(18(17)21)26-16-11-29-10-13(12(16)9-22-26)23-20(27)19-15-5-2-3-8-25(15)30-24-19/h4,6-7,9,13,15H,2-3,5,8,10-11H2,1H3,(H,23,27)	UJKGJPBBKXRSBP-UHFFFAOYSA-N	95611	US20250388602, Example 25	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95611	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95611&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			133081086	164036855							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130020	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2cccc(OC)c2Cl)n[nH]c1C	InChI=1S/C20H22ClN5O3/c1-4-12-11(2)24-25-19(12)20(27)23-14-9-29-10-16-13(14)8-22-26(16)15-6-5-7-17(28-3)18(15)21/h5-8,14H,4,9-10H2,1-3H3,(H,23,27)(H,24,25)	RKURNJMSZCBGDQ-UHFFFAOYSA-N	95612	US20250388602, Example 26	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95612	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95612&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			16832497	164036856							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130021	COc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2cc(C)c(C)cn2)c1Cl	InChI=1S/C21H21ClN4O3/c1-12-7-15(23-8-13(12)2)21(27)25-16-10-29-11-18-14(16)9-24-26(18)17-5-4-6-19(28-3)20(17)22/h4-9,16H,10-11H2,1-3H3,(H,25,27)	KSVQEGBAXASHDI-UHFFFAOYSA-N	95613	US20250388602, Example 27	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95613	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95613&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2049751	164036857							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130022	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2c(F)ccc(OC)c2Cl)ncn1C	InChI=1S/C20H21ClFN5O3/c1-4-14-18(23-10-26(14)2)20(28)25-13-8-30-9-15-11(13)7-24-27(15)19-12(22)5-6-16(29-3)17(19)21/h5-7,10,13H,4,8-9H2,1-3H3,(H,25,28)	RRHMWPDVMFPQTE-UHFFFAOYSA-N	95614	US20250388602, Example 28	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95614	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95614&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			73452181	164036858							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130023	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncc3n2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-14(23)19(18(17)22)28-16-11-31-10-15(13(16)9-25-28)26-21(29)20-24-8-12-4-2-3-7-27(12)20/h5-6,8-9,15H,2-4,7,10-11H2,1H3,(H,26,29)	OZSQMRWXRWIKIL-UHFFFAOYSA-N	95615	US20250388602, Example 29	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95615	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95615&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			24892565	164036859							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130024	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2n[nH]c3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-7-6-13(23)20(18(17)22)28-16-10-31-9-15(12(16)8-24-28)25-21(29)19-11-4-2-3-5-14(11)26-27-19/h6-8,15H,2-5,9-10H2,1H3,(H,25,29)(H,26,27)	PLTUBDSKAPWUHI-UHFFFAOYSA-N	95616	US20250388602, Example 30	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95616	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95616&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			133081087	164036860							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130025	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2noc3c2CCCC3)c1Cl	InChI=1S/C21H20ClFN4O4/c1-29-17-7-6-13(23)20(18(17)22)27-15-10-30-9-14(12(15)8-24-27)25-21(28)19-11-4-2-3-5-16(11)31-26-19/h6-8,14H,2-5,9-10H2,1H3,(H,25,28)	YJVZHGWYSGOMHE-UHFFFAOYSA-N	95617	US20250388602, Example 31	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95617	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95617&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7196782	164036861							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130026	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2c(F)ccc(OC)c2Cl)n[nH]c1C	InChI=1S/C20H21ClFN5O3/c1-4-11-10(2)25-26-18(11)20(28)24-14-8-30-9-15-12(14)7-23-27(15)19-13(22)5-6-16(29-3)17(19)21/h5-7,14H,4,8-9H2,1-3H3,(H,24,28)(H,25,26)	DTGAAEMYZKJUDG-UHFFFAOYSA-N	95618	US20250388602, Example 32	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95618	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95618&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7116925	164036862							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130027	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2cc(C)c(C)cn2)c1Cl	InChI=1S/C21H20ClFN4O3/c1-11-6-15(24-7-12(11)2)21(28)26-16-9-30-10-17-13(16)8-25-27(17)20-14(23)4-5-18(29-3)19(20)22/h4-8,16H,9-10H2,1-3H3,(H,26,28)	KAKIUCYXFRCYKF-UHFFFAOYSA-N	95619	US20250388602, Example 33	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95619	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95619&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			24892601	164036863							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130028	Cc1cccc(Cl)c1-n1ncc2c1COC[C@H]2NC(=O)c1ncn2c1CCCC2	InChI=1S/C21H22ClN5O2/c1-13-5-4-6-15(22)20(13)27-18-11-29-10-16(14(18)9-24-27)25-21(28)19-17-7-2-3-8-26(17)12-23-19/h4-6,9,12,16H,2-3,7-8,10-11H2,1H3,(H,25,28)	RNSKAWCUJFCZSH-UHFFFAOYSA-N	95620	US20250388602, Example 34	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95620	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95620&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7259160	164036864							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130029	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2c(C)cccc2Cl)ncn1C	InChI=1S/C20H22ClN5O2/c1-4-16-18(22-11-25(16)3)20(27)24-15-9-28-10-17-13(15)8-23-26(17)19-12(2)6-5-7-14(19)21/h5-8,11,15H,4,9-10H2,1-3H3,(H,24,27)	DWSOOCUXWZQHHM-UHFFFAOYSA-N	95621	US20250388602, Example 35	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95621	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95621&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			16283949	164036865							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130030	Cc1cccc(Cl)c1-n1ncc2c1COC[C@H]2NC(=O)c1ncc2n1CCCC2	InChI=1S/C21H22ClN5O2/c1-13-5-4-7-16(22)19(13)27-18-12-29-11-17(15(18)10-24-27)25-21(28)20-23-9-14-6-2-3-8-26(14)20/h4-5,7,9-10,17H,2-3,6,8,11-12H2,1H3,(H,25,28)	JQOTXCKKCTZIIN-UHFFFAOYSA-N	95622	US20250388602, Example 36	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95622	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95622&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			24980163	164036866							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130031	Cc1cccc(Cl)c1-n1ncc2c1COC[C@H]2NC(=O)c1n[nH]c2c1CCCC2	InChI=1S/C21H22ClN5O2/c1-12-5-4-7-15(22)20(12)27-18-11-29-10-17(14(18)9-23-27)24-21(28)19-13-6-2-3-8-16(13)25-26-19/h4-5,7,9,17H,2-3,6,8,10-11H2,1H3,(H,24,28)(H,25,26)	RRIYGIARYXGINY-UHFFFAOYSA-N	95623	US20250388602, Example 37	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95623	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95623&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			24981595	164036867							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130032	Cc1cccc(Cl)c1-n1ncc2c1COC[C@H]2NC(=O)c1noc2c1CCCC2	InChI=1S/C21H21ClN4O3/c1-12-5-4-7-15(22)20(12)26-17-11-28-10-16(14(17)9-23-26)24-21(27)19-13-6-2-3-8-18(13)29-25-19/h4-5,7,9,16H,2-3,6,8,10-11H2,1H3,(H,24,27)	FOWWXJLSUYKVIH-UHFFFAOYSA-N	95624	US20250388602, Example 38	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95624	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95624&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			24687847	164036868							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130033	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2c(C)cccc2Cl)n[nH]c1C	InChI=1S/C20H22ClN5O2/c1-4-13-12(3)24-25-18(13)20(27)23-16-9-28-10-17-14(16)8-22-26(17)19-11(2)6-5-7-15(19)21/h5-8,16H,4,9-10H2,1-3H3,(H,23,27)(H,24,25)	WCQJJTXDRYSVTH-UHFFFAOYSA-N	95625	US20250388602, Example 39	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95625	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95625&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			16535225	164036869							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130034	Cc1cnc(C(=O)N[C@@H]2COCc3c2cnn3-c2c(C)cccc2Cl)cc1C	InChI=1S/C21H21ClN4O2/c1-12-5-4-6-16(22)20(12)26-19-11-28-10-18(15(19)9-24-26)25-21(27)17-7-13(2)14(3)8-23-17/h4-9,18H,10-11H2,1-3H3,(H,25,27)	CVUVNDIHWZAQDP-UHFFFAOYSA-N	95626	US20250388602, Example 40	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95626	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95626&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			1132644	164036870							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130035	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2c(C)cccc2F)ncn1C	InChI=1S/C20H22FN5O2/c1-4-16-18(22-11-25(16)3)20(27)24-15-9-28-10-17-13(15)8-23-26(17)19-12(2)6-5-7-14(19)21/h5-8,11,15H,4,9-10H2,1-3H3,(H,24,27)	GPOXQPRNOFYAHW-UHFFFAOYSA-N	95627	US20250388602, Example 41	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95627	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95627&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7799160	164036871							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130036	O=C(N[C@@H]1COCc2c1cnn2-c1ccccc1F)c1n[nH]c2c1CCCC2	InChI=1S/C20H20FN5O2/c21-14-6-2-4-8-17(14)26-18-11-28-10-16(13(18)9-22-26)23-20(27)19-12-5-1-3-7-15(12)24-25-19/h2,4,6,8-9,16H,1,3,5,7,10-11H2,(H,23,27)(H,24,25)	BKRZWAJKPIHFPW-UHFFFAOYSA-N	95628	US20250388602, Example 42	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95628	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95628&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			75666009	164036872							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130037	O=C(N[C@@H]1COCc2c1cnn2-c1ccccc1F)c1noc2c1CCCC2	InChI=1S/C20H19FN4O3/c21-14-6-2-3-7-16(14)25-17-11-27-10-15(13(17)9-22-25)23-20(26)19-12-5-1-4-8-18(12)28-24-19/h2-3,6-7,9,15H,1,4-5,8,10-11H2,(H,23,26)	KSVGCLOXNRGNAX-UHFFFAOYSA-N	95629	US20250388602, Example 43	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95629	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95629&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			75644414	164036873							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130038	CCc1c(C(=O)N[C@@H]2COCc3c2cnn3-c2c(C)cccc2F)n[nH]c1C	InChI=1S/C20H22FN5O2/c1-4-13-12(3)24-25-18(13)20(27)23-16-9-28-10-17-14(16)8-22-26(17)19-11(2)6-5-7-15(19)21/h5-8,16H,4,9-10H2,1-3H3,(H,23,27)(H,24,25)	HYHOOLBWCCYFGE-UHFFFAOYSA-N	95630	US20250388602, Example 44	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95630	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95630&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			3273284	164036874							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130039	Cc1cnc(C(=O)N[C@@H]2COCc3c2cnn3-c2ccccc2F)cc1C	InChI=1S/C20H19FN4O2/c1-12-7-16(22-8-13(12)2)20(26)24-17-10-27-11-19-14(17)9-23-25(19)18-6-4-3-5-15(18)21/h3-9,17H,10-11H2,1-2H3,(H,24,26)	PQDQZXFEMQVSPZ-UHFFFAOYSA-N	95631	US20250388602, Example 45	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95631	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95631&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2571054	164036875							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130040	O=C(N[C@@H]1COCc2c1cnn2-c1c(F)cccc1Cl)c1n[nH]c2c1CCCC2	InChI=1S/C20H19ClFN5O2/c21-13-5-3-6-14(22)19(13)27-17-10-29-9-16(12(17)8-23-27)24-20(28)18-11-4-1-2-7-15(11)25-26-18/h3,5-6,8,16H,1-2,4,7,9-10H2,(H,24,28)(H,25,26)	TVHUVKLXMOUXEE-UHFFFAOYSA-N	95632	US20250388602, Example 46	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95632	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95632&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4789729	164036876							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130041	O=C(N[C@@H]1COCc2c1cnn2-c1c(F)cccc1Cl)c1ncc2n1CCCC2	InChI=1S/C20H19ClFN5O2/c21-14-5-3-6-15(22)18(14)27-17-11-29-10-16(13(17)9-24-27)25-20(28)19-23-8-12-4-1-2-7-26(12)19/h3,5-6,8-9,16H,1-2,4,7,10-11H2,(H,25,28)	GPTLMQUFNZVBRB-UHFFFAOYSA-N	95633	US20250388602, Example 47	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95633	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95633&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			16249963	164036877							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130042	Cc1cnc(C(=O)N[C@@H]2COCc3c2cnn3-c2c(F)cccc2Cl)cc1C	InChI=1S/C20H18ClFN4O2/c1-11-6-16(23-7-12(11)2)20(27)25-17-9-28-10-18-13(17)8-24-26(18)19-14(21)4-3-5-15(19)22/h3-8,17H,9-10H2,1-2H3,(H,25,27)	VPWKCHAFZYCIKA-UHFFFAOYSA-N	95634	US20250388602, Example 48	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95634	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95634&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			25161846	164036878							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130043	CS(=O)(=O)c1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1	InChI=1S/C21H23N5O4S/c1-31(28,29)15-6-4-5-14(9-15)26-19-12-30-11-17(16(19)10-23-26)24-21(27)20-18-7-2-3-8-25(18)13-22-20/h4-6,9-10,13,17H,2-3,7-8,11-12H2,1H3,(H,24,27)	YSADHZMEAGVOMD-UHFFFAOYSA-N	95635	US20250388602, Example 49	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 5500							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95635	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95635&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			25162391	164036879							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130044	O=C(N[C@@H]1COCc2c1cnn2-c1cccc(C(F)(F)F)c1Cl)c1ncn2c1CCCC2	InChI=1S/C21H19ClF3N5O2/c22-18-13(21(23,24)25)4-3-6-15(18)30-17-10-32-9-14(12(17)8-27-30)28-20(31)19-16-5-1-2-7-29(16)11-26-19/h3-4,6,8,11,14H,1-2,5,7,9-10H2,(H,28,31)	DOSNEEHLTCTSQN-UHFFFAOYSA-N	95636	US20250388602, Example 50	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95636	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95636&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2569518	164036880							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130045	O=C(N[C@@H]1COCc2c1cnn2-c1ccccc1Cl)c1ncn2c1CCCC2	InChI=1S/C20H20ClN5O2/c21-14-5-1-2-6-16(14)26-18-11-28-10-15(13(18)9-23-26)24-20(27)19-17-7-3-4-8-25(17)12-22-19/h1-2,5-6,9,12,15H,3-4,7-8,10-11H2,(H,24,27)	BANVEZDAPQNKLI-UHFFFAOYSA-N	95637	US20250388602, Example 51	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95637	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95637&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7567657	164036881							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130046	Cc1ccccc1-n1ncc2c1COC[C@H]2NC(=O)c1ncn2c1CCCC2	InChI=1S/C21H23N5O2/c1-14-6-2-3-7-17(14)26-19-12-28-11-16(15(19)10-23-26)24-21(27)20-18-8-4-5-9-25(18)13-22-20/h2-3,6-7,10,13,16H,4-5,8-9,11-12H2,1H3,(H,24,27)	GAALNNZYJJCJBE-UHFFFAOYSA-N	95638	US20250388602, Example 52	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95638	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95638&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2580339	164036882							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130047	Cc1ccc(Cl)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1	InChI=1S/C21H22ClN5O2/c1-13-5-6-15(22)18(8-13)27-19-11-29-10-16(14(19)9-24-27)25-21(28)20-17-4-2-3-7-26(17)12-23-20/h5-6,8-9,12,16H,2-4,7,10-11H2,1H3,(H,25,28)	LXOYEDCXIGKKPB-UHFFFAOYSA-N	95639	US20250388602, Example 53	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95639	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95639&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4883851	164036883							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130048	COc1ccccc1-n1ncc2c1COC[C@H]2NC(=O)c1ncn2c1CCCC2	InChI=1S/C21H23N5O3/c1-28-19-8-3-2-6-16(19)26-18-12-29-11-15(14(18)10-23-26)24-21(27)20-17-7-4-5-9-25(17)13-22-20/h2-3,6,8,10,13,15H,4-5,7,9,11-12H2,1H3,(H,24,27)	GFGGXBGEPZPBIL-UHFFFAOYSA-N	95640	US20250388602, Example 54	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95640	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95640&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			7169985	164036884							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130049	O=C(N[C@@H]1COCc2c1cnn2-c1ccccc1C(F)(F)F)c1ncn2c1CCCC2	InChI=1S/C21H20F3N5O2/c22-21(23,24)14-5-1-2-6-16(14)29-18-11-31-10-15(13(18)9-26-29)27-20(30)19-17-7-3-4-8-28(17)12-25-19/h1-2,5-6,9,12,15H,3-4,7-8,10-11H2,(H,27,30)	VBPWTGLLMKAPHE-UHFFFAOYSA-N	95641	US20250388602, Example 55	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95641	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95641&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2546477	164036885							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130050	COc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1	InChI=1S/C21H23N5O3/c1-28-15-6-4-5-14(9-15)26-19-12-29-11-17(16(19)10-23-26)24-21(27)20-18-7-2-3-8-25(18)13-22-20/h4-6,9-10,13,17H,2-3,7-8,11-12H2,1H3,(H,24,27)	BXYVIVYXCMKCRI-UHFFFAOYSA-N	95642	US20250388602, Example 56	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95642	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95642&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4178147	164036886							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130051	O=C(N[C@@H]1COCc2c1cnn2-c1cccc(OC(F)(F)F)c1)c1ncn2c1CCCC2	InChI=1S/C21H20F3N5O3/c22-21(23,24)32-14-5-3-4-13(8-14)29-18-11-31-10-16(15(18)9-26-29)27-20(30)19-17-6-1-2-7-28(17)12-25-19/h3-5,8-9,12,16H,1-2,6-7,10-11H2,(H,27,30)	KISQISIJQFBJAQ-UHFFFAOYSA-N	95643	US20250388602, Example 57	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 550							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95643	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95643&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2429550	164036887							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130052	Cc1cccc(F)c1-n1ncc2c1COC[C@H]2NC(=O)c1ncn2c1CCCC2	InChI=1S/C21H22FN5O2/c1-13-5-4-6-15(22)20(13)27-18-11-29-10-16(14(18)9-24-27)25-21(28)19-17-7-2-3-8-26(17)12-23-19/h4-6,9,12,16H,2-3,7-8,10-11H2,1H3,(H,25,28)	ZXFXIIGCCQBFBR-UHFFFAOYSA-N	95644	US20250388602, Example 58	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95644	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95644&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2423420	164036888							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130053	O=C(N[C@@H]1COCc2c1cnn2-c1c(F)cccc1F)c1ncn2c1CCCC2	InChI=1S/C20H19F2N5O2/c21-13-4-3-5-14(22)19(13)27-17-10-29-9-15(12(17)8-24-27)25-20(28)18-16-6-1-2-7-26(16)11-23-18/h3-5,8,11,15H,1-2,6-7,9-10H2,(H,25,28)	YAHDNCYAPKLUDP-UHFFFAOYSA-N	95645	US20250388602, Example 59	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95645	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95645&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			5888189	164036889							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130054	COc1cccc(Cl)c1-n1ncc2c1COC[C@H]2NC(=O)c1ncn2c1CCCC2	InChI=1S/C21H22ClN5O3/c1-29-18-7-4-5-14(22)20(18)27-17-11-30-10-15(13(17)9-24-27)25-21(28)19-16-6-2-3-8-26(16)12-23-19/h4-5,7,9,12,15H,2-3,6,8,10-11H2,1H3,(H,25,28)	ZIDLZJSKVZKFTD-UHFFFAOYSA-N	95646	US20250388602, Example 60	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95646	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95646&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2369164	164036890							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130055	COc1cccc(C)c1-n1ncc2c1COC[C@H]2NC(=O)c1ncn2c1CCCC2	InChI=1S/C22H25N5O3/c1-14-6-5-8-19(29-2)21(14)27-18-12-30-11-16(15(18)10-24-27)25-22(28)20-17-7-3-4-9-26(17)13-23-20/h5-6,8,10,13,16H,3-4,7,9,11-12H2,1-2H3,(H,25,28)	RFZLVUANXOCUNG-UHFFFAOYSA-N	95647	US20250388602, Example 61	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95647	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95647&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4217075	164036891							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130056	O=C(N[C@@H]1COCc2c1cnn2-c1cccc(O)c1Cl)c1ncn2c1CCCC2	InChI=1S/C20H20ClN5O3/c21-18-14(5-3-6-17(18)27)26-16-10-29-9-13(12(16)8-23-26)24-20(28)19-15-4-1-2-7-25(15)11-22-19/h3,5-6,8,11,13,27H,1-2,4,7,9-10H2,(H,24,28)	YXHXVMJVCRUNBV-UHFFFAOYSA-N	95648	US20250388602, Example 62	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95648	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95648&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2085043	164036892							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130057	CN(C)CCOc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C24H29ClN6O3/c1-29(2)10-11-34-21-8-5-7-18(22(21)25)31-20-14-33-13-17(16(20)12-27-31)28-24(32)23-19-6-3-4-9-30(19)15-26-23/h5,7-8,12,15,17H,3-4,6,9-11,13-14H2,1-2H3,(H,28,32)	BKNCTJXFLWWDQF-UHFFFAOYSA-N	95649	US20250388602, Example 63	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95649	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95649&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4027300	164036893							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130058	CN(C)C(=O)COc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C24H27ClN6O4/c1-29(2)21(32)13-35-20-8-5-7-17(22(20)25)31-19-12-34-11-16(15(19)10-27-31)28-24(33)23-18-6-3-4-9-30(18)14-26-23/h5,7-8,10,14,16H,3-4,6,9,11-13H2,1-2H3,(H,28,33)	HEDLOLSAGWKUAV-UHFFFAOYSA-N	95650	US20250388602, Example 64	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95650	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95650&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			3317062	164036894							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130059	CNC(=O)COc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C23H25ClN6O4/c1-25-20(31)12-34-19-7-4-6-16(21(19)24)30-18-11-33-10-15(14(18)9-27-30)28-23(32)22-17-5-2-3-8-29(17)13-26-22/h4,6-7,9,13,15H,2-3,5,8,10-12H2,1H3,(H,25,31)(H,28,32)	FXRHDDXDMGAFJQ-UHFFFAOYSA-N	95651	US20250388602, Example 65	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95651	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95651&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2089406	164036895							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130060	CC(=O)NCCOc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C24H27ClN6O4/c1-15(32)26-8-10-35-21-7-4-6-18(22(21)25)31-20-13-34-12-17(16(20)11-28-31)29-24(33)23-19-5-2-3-9-30(19)14-27-23/h4,6-7,11,14,17H,2-3,5,8-10,12-13H2,1H3,(H,26,32)(H,29,33)	UYGOAACDKGGKFP-UHFFFAOYSA-N	95652	US20250388602, Example 66	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95652	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95652&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			16247418	164036896							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130061	COCCOc1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C23H26ClN5O4/c1-31-9-10-33-20-7-4-6-17(21(20)24)29-19-13-32-12-16(15(19)11-26-29)27-23(30)22-18-5-2-3-8-28(18)14-25-22/h4,6-7,11,14,16H,2-3,5,8-10,12-13H2,1H3,(H,27,30)	XOPGODVQDNSDOI-UHFFFAOYSA-N	95653	US20250388602, Example 67	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95653	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95653&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			3659548	164036897							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130062	O=C(N[C@@H]1COCc2c1cnn2-c1cccc(OCCO)c1Cl)c1ncn2c1CCCC2	InChI=1S/C22H24ClN5O4/c23-20-16(5-3-6-19(20)32-9-8-29)28-18-12-31-11-15(14(18)10-25-28)26-22(30)21-17-4-1-2-7-27(17)13-24-21/h3,5-6,10,13,15,29H,1-2,4,7-9,11-12H2,(H,26,30)	IHFKEGQCZQXOIT-UHFFFAOYSA-N	95654	US20250388602, Example 68	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95654	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95654&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			4784386	164036898							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130063	CC(C)OC(=O)c1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C24H26ClN5O4/c1-14(2)34-24(32)15-6-5-8-18(21(15)25)30-20-12-33-11-17(16(20)10-27-30)28-23(31)22-19-7-3-4-9-29(19)13-26-22/h5-6,8,10,13-14,17H,3-4,7,9,11-12H2,1-2H3,(H,28,31)	CFGXXSRXLCSXHI-UHFFFAOYSA-N	95655	US20250388602, Example 69	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95655	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95655&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2425463	164036899							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130064	CN(C)C(=O)c1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C23H25ClN6O3/c1-28(2)23(32)14-6-5-8-17(20(14)24)30-19-12-33-11-16(15(19)10-26-30)27-22(31)21-18-7-3-4-9-29(18)13-25-21/h5-6,8,10,13,16H,3-4,7,9,11-12H2,1-2H3,(H,27,31)	WMEOKPKVWXLVEZ-UHFFFAOYSA-N	95656	US20250388602, Example 70	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95656	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95656&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2358005	164036900							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130065	O=C(N[C@@H]1COCc2c1cnn2-c1cccc(C(=O)N2CCCC2)c1Cl)c1ncn2c1CCCC2	InChI=1S/C25H27ClN6O3/c26-22-16(25(34)30-9-3-4-10-30)6-5-8-19(22)32-21-14-35-13-18(17(21)12-28-32)29-24(33)23-20-7-1-2-11-31(20)15-27-23/h5-6,8,12,15,18H,1-4,7,9-11,13-14H2,(H,29,33)	BPYUPNREHQILSA-UHFFFAOYSA-N	95657	US20250388602, Example 71	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95657	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95657&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2409536	164036901							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130066	O=C(N[C@@H]1COCc2c1cnn2-c1cccc(C(=O)N2CCCCC2)c1Cl)c1ncn2c1CCCC2	InChI=1S/C26H29ClN6O3/c27-23-17(26(35)31-10-3-1-4-11-31)7-6-9-20(23)33-22-15-36-14-19(18(22)13-29-33)30-25(34)24-21-8-2-5-12-32(21)16-28-24/h6-7,9,13,16,19H,1-5,8,10-12,14-15H2,(H,30,34)	VCNMTTYLZDSOBW-UHFFFAOYSA-N	95658	US20250388602, Example 72	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		<10.00							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95658	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95658&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			2452505	164036902							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130067	O=C(N[C@@H]1COCc2c1cnn2-c1cccc(C(=O)N2CCOCC2)c1Cl)c1ncn2c1CCCC2	InChI=1S/C25H27ClN6O4/c26-22-16(25(34)30-8-10-35-11-9-30)4-3-6-19(22)32-21-14-36-13-18(17(21)12-28-32)29-24(33)23-20-5-1-2-7-31(20)15-27-23/h3-4,6,12,15,18H,1-2,5,7-11,13-14H2,(H,29,33)	FSCXVABKPISUJT-UHFFFAOYSA-N	95659	US20250388602, Example 73	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95659	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95659&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			3279586	164036903							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130068	CCN(CC)C(=O)c1cccc(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C25H29ClN6O3/c1-3-30(4-2)25(34)16-8-7-10-19(22(16)26)32-21-14-35-13-18(17(21)12-28-32)29-24(33)23-20-9-5-6-11-31(20)15-27-23/h7-8,10,12,15,18H,3-6,9,11,13-14H2,1-2H3,(H,29,33)	JZXSOKMOYNBOAM-UHFFFAOYSA-N	95660	US20250388602, Example 74	Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens		 55.0							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95660	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5610&target=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95660&enzyme=Dihydroorotate+dehydrogenase+%28quinone%29%2C+mitochondrial&column=ki&startPg=0&Increment=50&submit=Search			3375891	164036904							1	MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR	6SYP,6FMD,3U2O,9EG9,9CZE,9CCC,5K9D,5K9C,9M4M,9DHJ,9DHI,9DHH,9DHG,9BKM,8VHM,8VHL,8DHH,8DHG,8DHF,7K2U,6VND,6GK0,6ET4,3ZWT,3ZWS,3G0X,3G0U,3FJL,3FJ6,3F1Q,2PRM,2PRL,2PRH,2BXV,2B0M,1D3H,1D3G,2FQI,2FPY,2FPV,2FPT,9S1I,9EZ9,8RAK,6M2B,6IDJ,5ZFB,5ZFA,5ZF9,5ZF8,5ZF7,5ZF4,5MVC,5HQE,5HIN,5H73,5H2Z,4ZMG,4ZL1,4YLW,4RR4,4RLI,4RKA,4RK8,4LS2,4LS1,4LS0,4JTU,4JTT,4JTS,4JS3,4JGD,3W7R,3KVM,3KVL,3KVK,3KVJ,9UB2,9M4O,8K4F,7Z6C,6QU7,6LP8,6LP7,6LP6,6JME,6JMD,6J3C,6J3B,9BKO,9BKN,9I2Y,6LZL,5MUT,2WV8,6CJG,6CJF,4OQV,4IGH,5MVD,5TCE	Dihydroorotate dehydrogenase (quinone), mitochondrial	PYRD_HUMAN	Q02127	A8K8C8 Q6P176																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130069	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 1A2	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2146&target=Cytochrome+P450+1A2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+1A2&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN	2HI4	Cytochrome P450 1A2	CP1A2_HUMAN	P05177	Q16754 Q6NWU3 Q6NWU5 Q9BXX7 Q9UK49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130070	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 2A6	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4987&target=Cytochrome+P450+2A6&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+2A6&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR	2PG7,2PG6	Cytochrome P450 2A6	CP2A6_HUMAN	P11509	A7YAE5 B2R7F6 P00190 P10890 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130071	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 2B6	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6685&target=Cytochrome+P450+2B6&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+2B6&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR		Cytochrome P450 2B6	CP2B6_HUMAN	P20813	B4DWP3 Q2V565 Q9UK46																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130072	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 2C8	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7129&target=Cytochrome+P450+2C8&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+2C8&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV		Cytochrome P450 2C8	CP2C8_HUMAN	P10632	A8K9N8 B0AZN2 B7Z1F6 Q5VX93 Q8WWB1 Q9UCZ9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130073	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 2C9	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2128&target=Cytochrome+P450+2C9&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+2C9&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV		Cytochrome P450 2C9	CP2C9_HUMAN	P11712	P11713 Q16756 Q16872 Q5VX92 Q6IRV8 Q8WW80																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130074	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 2C19	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2148&target=Cytochrome+P450+2C19&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+2C19&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV		Cytochrome P450 2C19	CP2CJ_HUMAN	P33261	P33259 Q8WZB1 Q8WZB2 Q9UCD4																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130075	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	cyp2d6	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=356&target=cyp2d6&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=cyp2d6&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR	6CSD,6CSB	Cytochrome P450 2D6	CP2D6_HUMAN	P10635	Q16752 Q2XND6 Q2XND7 Q2XNE0 Q6B012 Q6NXU8		Cytochrome P450	C1ID52_HUMAN	C1ID52																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
130076	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 2E1	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5173&target=Cytochrome+P450+2E1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+2E1&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS	3T3Z,3LC4,3KOH,3GPH,3E6I,3E4E	Cytochrome P450 2E1	CP2E1_HUMAN	P05181	Q5VZD5 Q6NWT9 Q9UK47																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130077	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 3A4	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2127&target=Cytochrome+P450+3A4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+3A4&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA	7LXL,3NXU,2V0M,2J0D,1W0G,1W0F,1W0E,9GK1,4NY4	Cytochrome P450 3A4	CP3A4_HUMAN	P08684	P05184 Q16757 Q9UK50		Cytochrome P450 3A	Q6GRK0_HUMAN	Q6GRK0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
130078	COc1ccc(F)c(-n2ncc3c2COC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C21H21ClFN5O3/c1-30-17-6-5-13(23)20(18(17)22)28-16-10-31-9-14(12(16)8-25-28)26-21(29)19-15-4-2-3-7-27(15)11-24-19/h5-6,8,11,14H,2-4,7,9-10H2,1H3,(H,26,29)	FJRLMPPZRSHFHU-UHFFFAOYSA-N	95595	US20250388602, Example 9	Cytochrome P450 3A4	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95595	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2127&target=Cytochrome+P450+3A4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95595&enzyme=Cytochrome+P450+3A4&column=ki&startPg=0&Increment=50&submit=Search			2220729	164036839							1	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA	7LXL,3NXU,2V0M,2J0D,1W0G,1W0F,1W0E,9GK1,4NY4	Cytochrome P450 3A4	CP3A4_HUMAN	P08684	P05184 Q16757 Q9UK50		Cytochrome P450 3A	Q6GRK0_HUMAN	Q6GRK0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
130079	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 1A2	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2146&target=Cytochrome+P450+1A2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+1A2&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN	2HI4	Cytochrome P450 1A2	CP1A2_HUMAN	P05177	Q16754 Q6NWU3 Q6NWU5 Q9BXX7 Q9UK49																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130080	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 2A6	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4987&target=Cytochrome+P450+2A6&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+2A6&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR	2PG7,2PG6	Cytochrome P450 2A6	CP2A6_HUMAN	P11509	A7YAE5 B2R7F6 P00190 P10890 Q16803 Q4VAT9 Q4VAU0 Q4VAU1 Q9H1Z7 Q9UCU0 Q9UK48																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130081	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 2B6	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=6685&target=Cytochrome+P450+2B6&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+2B6&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR		Cytochrome P450 2B6	CP2B6_HUMAN	P20813	B4DWP3 Q2V565 Q9UK46																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130082	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 2C8	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=7129&target=Cytochrome+P450+2C8&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+2C8&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV		Cytochrome P450 2C8	CP2C8_HUMAN	P10632	A8K9N8 B0AZN2 B7Z1F6 Q5VX93 Q8WWB1 Q9UCZ9																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130083	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 2C9	Homo sapiens		 2000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2128&target=Cytochrome+P450+2C9&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+2C9&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV		Cytochrome P450 2C9	CP2C9_HUMAN	P11712	P11713 Q16756 Q16872 Q5VX92 Q6IRV8 Q8WW80																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130084	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 2C19	Homo sapiens		 18000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2148&target=Cytochrome+P450+2C19&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+2C19&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV		Cytochrome P450 2C19	CP2CJ_HUMAN	P33261	P33259 Q8WZB1 Q8WZB2 Q9UCD4																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130085	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	cyp2d6	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=356&target=cyp2d6&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=cyp2d6&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR	6CSD,6CSB	Cytochrome P450 2D6	CP2D6_HUMAN	P10635	Q16752 Q2XND6 Q2XND7 Q2XNE0 Q6B012 Q6NXU8		Cytochrome P450	C1ID52_HUMAN	C1ID52																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
130086	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 2E1	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5173&target=Cytochrome+P450+2E1&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+2E1&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS	3T3Z,3LC4,3KOH,3GPH,3E6I,3E4E	Cytochrome P450 2E1	CP2E1_HUMAN	P05181	Q5VZD5 Q6NWT9 Q9UK47																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130087	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 3A4	Homo sapiens		 16000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2127&target=Cytochrome+P450+3A4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+3A4&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA	7LXL,3NXU,2V0M,2J0D,1W0G,1W0F,1W0E,9GK1,4NY4	Cytochrome P450 3A4	CP3A4_HUMAN	P08684	P05184 Q16757 Q9UK50		Cytochrome P450 3A	Q6GRK0_HUMAN	Q6GRK0																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
130088	COc1ccc(F)c(-n2ncc3c2CCC[C@H]3NC(=O)c2ncn3c2CCCC3)c1Cl	InChI=1S/C22H23ClFN5O2/c1-31-18-9-8-14(24)21(19(18)23)29-16-7-4-5-15(13(16)11-26-29)27-22(30)20-17-6-2-3-10-28(17)12-25-20/h8-9,11-12,15H,2-7,10H2,1H3,(H,27,30)	FYTXRQRKAFGLRE-UHFFFAOYSA-N	95661	US20250388602, Compound C	Cytochrome P450 3A4	Homo sapiens		>30000							US Patent		10.7270/Q2Q52VFS			US20250388602	Barf, T; Lain, S; Bengtsson, C; Sandberg, L; Yngve, U	12/25/2025	5/6/2026	Genase Therapeutics	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95661	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2127&target=Cytochrome+P450+3A4&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95661&enzyme=Cytochrome+P450+3A4&column=ki&startPg=0&Increment=50&submit=Search			2906049	164036905							1	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA	7LXL,3NXU,2V0M,2J0D,1W0G,1W0F,1W0E,9GK1,4NY4	Cytochrome P450 3A4	CP3A4_HUMAN	P08684	P05184 Q16757 Q9UK50		Cytochrome P450 3A	Q6GRK0_HUMAN	Q6GRK0