BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 130089 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NC2CC2)s1 InChI=1S/C21H26N4O3S/c1-12-6-7-13(19(27)24-15-4-2-3-5-17(15)26)10-16(12)25-20(28)18-11-22-21(29-18)23-14-8-9-14/h6-7,10-11,14-15,17,26H,2-5,8-9H2,1H3,(H,22,23)(H,24,27)(H,25,28) LQRKIYSTTCSILN-UHFFFAOYSA-N 95663 2-(cyclopropylamino)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-1,3-thiazole-5-carboxamide::US12509424, Example 1 Platelet-derived growth factor subunit B Homo sapiens 5.90 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95663 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95663&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 405724 164036907 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130090 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccccc2)c1 InChI=1S/C26H27N3O3/c1-17-11-12-19(25(31)28-22-9-5-6-10-24(22)30)14-23(17)29-26(32)21-13-20(15-27-16-21)18-7-3-2-4-8-18/h2-4,7-8,11-16,22,24,30H,5-6,9-10H2,1H3,(H,28,31)(H,29,32) PLJKEVWULFQKBC-UHFFFAOYSA-N 95664 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-phenylpyridine-3-carboxamidc::N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-phenylpyridine-3-carboxamide::US12509424, Example 2 Platelet-derived growth factor subunit B Homo sapiens 22.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95664 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95664&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 46903543 164036908 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130091 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(CC2CC2)s1 InChI=1S/C22H27N3O3S/c1-13-6-9-15(21(27)24-16-4-2-3-5-18(16)26)11-17(13)25-22(28)19-12-23-20(29-19)10-14-7-8-14/h6,9,11-12,14,16,18,26H,2-5,7-8,10H2,1H3,(H,24,27)(H,25,28) FZRDMKQUAXCLIL-UHFFFAOYSA-N 95665 2-(cyclopropylmethyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-1,3-thiazole-5-carboxamide::US12509424, Example 3 Platelet-derived growth factor subunit B Homo sapiens 82.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95665 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95665&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 46942783 164036909 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130092 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(NC2CC2)c1 InChI=1S/C23H28N4O3/c1-14-6-7-15(22(29)26-19-4-2-3-5-21(19)28)11-20(14)27-23(30)16-10-18(13-24-12-16)25-17-8-9-17/h6-7,10-13,17,19,21,25,28H,2-5,8-9H2,1H3,(H,26,29)(H,27,30) AJDCRNJTDCVDNX-UHFFFAOYSA-N 95666 5-(cyclopropylamino)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 4 Platelet-derived growth factor subunit B Homo sapiens 4.90 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95666 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95666&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 46942839 164036910 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130093 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(-c2ccccc2)o1 InChI=1S/C24H25N3O4/c1-15-11-12-17(22(29)26-18-9-5-6-10-20(18)28)13-19(15)27-23(30)21-14-25-24(31-21)16-7-3-2-4-8-16/h2-4,7-8,11-14,18,20,28H,5-6,9-10H2,1H3,(H,26,29)(H,27,30) KIRYDGVFYPLUHL-UHFFFAOYSA-N 95667 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-2-phenyl-1,3-oxazole-5-carboxamide::US12509424, Example 5 Platelet-derived growth factor subunit B Homo sapiens 6.10 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95667 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95667&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1667643 164036911 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130094 Cc1ccc(C(=O)N[C@H](CO)c2ccccc2)cc1NC(=O)c1cncc(-c2ccccc2)c1 InChI=1S/C28H25N3O3/c1-19-12-13-22(27(33)31-26(18-32)21-10-6-3-7-11-21)15-25(19)30-28(34)24-14-23(16-29-17-24)20-8-4-2-5-9-20/h2-17,26,32H,18H2,1H3,(H,30,34)(H,31,33) QOQQBIDWSMMVBT-UHFFFAOYSA-N 95668 N-(5-{[(1S)-2-hydroxy-1-phenylethyl]carbamoyl}-2-methylphenyl)-5-phenylpyridine-3-carboxamide::US12509424, Example 6 Platelet-derived growth factor subunit B Homo sapiens 12.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95668 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95668&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 46944099 164036912 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130095 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(OC(C)C)c1 InChI=1S/C23H29N3O4/c1-14(2)30-18-10-17(12-24-13-18)23(29)26-20-11-16(9-8-15(20)3)22(28)25-19-6-4-5-7-21(19)27/h8-14,19,21,27H,4-7H2,1-3H3,(H,25,28)(H,26,29) PXOKLWGZCPMIKU-UHFFFAOYSA-N 95669 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-[(propan-2-yl)oxy]pyridine-3-carboxamide::US12509424, Example 7 Platelet-derived growth factor subunit B Homo sapiens 170 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95669 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95669&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 46944229 164036913 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130096 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NCC2CC2)s1 InChI=1S/C22H28N4O3S/c1-13-6-9-15(20(28)25-16-4-2-3-5-18(16)27)10-17(13)26-21(29)19-12-24-22(30-19)23-11-14-7-8-14/h6,9-10,12,14,16,18,27H,2-5,7-8,11H2,1H3,(H,23,24)(H,25,28)(H,26,29) JNPQBTSSJDISOW-UHFFFAOYSA-N 95670 2-[(cyclopropylmethyl)amino]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-1,3-thiazole-5-carboxamide::US12509424, Example 8 Platelet-derived growth factor subunit B Homo sapiens 6.00 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95670&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 46948700 164036914 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130097 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccc(Cl)cc2)c1 InChI=1S/C26H26ClN3O3/c1-16-6-7-18(25(32)29-22-4-2-3-5-24(22)31)13-23(16)30-26(33)20-12-19(14-28-15-20)17-8-10-21(27)11-9-17/h6-15,22,24,31H,2-5H2,1H3,(H,29,32)(H,30,33) UTJGNNMKXDUXJM-UHFFFAOYSA-N 95671 5-(4-chlorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 9 Platelet-derived growth factor subunit B Homo sapiens 26.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95671 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95671&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 49778328 164036915 C06049 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130098 CCCc1ncc(C(=O)Nc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2C)s1 InChI=1S/C21H27N3O3S/c1-3-6-19-22-12-18(28-19)21(27)24-16-11-14(10-9-13(16)2)20(26)23-15-7-4-5-8-17(15)25/h9-12,15,17,25H,3-8H2,1-2H3,(H,23,26)(H,24,27) XAYVMMHVVBKGKT-UHFFFAOYSA-N 95672 N-(5-{[(1 S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-2-propyl-1,3-thiazole-5-carboxamide::US12509424, Example 10 Platelet-derived growth factor subunit B Homo sapiens 220 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95672&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 49778418 164036916 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130099 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2cccc(Cl)c2)c1 InChI=1S/C26H26ClN3O3/c1-16-9-10-18(25(32)29-22-7-2-3-8-24(22)31)13-23(16)30-26(33)20-11-19(14-28-15-20)17-5-4-6-21(27)12-17/h4-6,9-15,22,24,31H,2-3,7-8H2,1H3,(H,29,32)(H,30,33) ZSWVYIRBDQZTPP-UHFFFAOYSA-N 95673 5-(3-chlorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 11 Platelet-derived growth factor subunit B Homo sapiens 17.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95673&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 49791415 164036917 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130100 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccccc2C)c1 InChI=1S/C27H29N3O3/c1-17-7-3-4-8-22(17)20-13-21(16-28-15-20)27(33)30-24-14-19(12-11-18(24)2)26(32)29-23-9-5-6-10-25(23)31/h3-4,7-8,11-16,23,25,31H,5-6,9-10H2,1-2H3,(H,29,32)(H,30,33) XHULIWWANKIPDB-UHFFFAOYSA-N 95674 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-(2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 12 Platelet-derived growth factor subunit B Homo sapiens 170 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95674&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 7870749 164036918 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130101 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccccc2Cl)c1 InChI=1S/C26H26ClN3O3/c1-16-10-11-17(25(32)29-22-8-4-5-9-24(22)31)13-23(16)30-26(33)19-12-18(14-28-15-19)20-6-2-3-7-21(20)27/h2-3,6-7,10-15,22,24,31H,4-5,8-9H2,1H3,(H,29,32)(H,30,33) NCRBUDMVQWTQPJ-UHFFFAOYSA-N 95675 5-(2-chlorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 13 Platelet-derived growth factor subunit B Homo sapiens 140 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95675 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95675&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 49795454 164036919 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130102 CCC[C@@H](CO)NC(=O)c1ccc(C)c(NC(=O)c2cncc(-c3ccccc3)c2)c1 InChI=1S/C25H27N3O3/c1-3-7-22(16-29)27-24(30)19-11-10-17(2)23(13-19)28-25(31)21-12-20(14-26-15-21)18-8-5-4-6-9-18/h4-6,8-15,22,29H,3,7,16H2,1-2H3,(H,27,30)(H,28,31) CWVKJQZXXSGXTN-UHFFFAOYSA-N 95676 N-(5-{[(2S)-1-hydroxypentan-2-yl]carbamoyl}-2-methylphenyl)-5-phenylpyridine-3-carboxamide::US12509424, Example 14 Platelet-derived growth factor subunit B Homo sapiens 40.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95676 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95676&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 49795520 164036920 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130103 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(/C=C/C2CC2)c1 InChI=1S/C25H29N3O3/c1-16-6-11-19(24(30)27-21-4-2-3-5-23(21)29)13-22(16)28-25(31)20-12-18(14-26-15-20)10-9-17-7-8-17/h6,9-15,17,21,23,29H,2-5,7-8H2,1H3,(H,27,30)(H,28,31) BLNHUYJNNXACSA-UHFFFAOYSA-N 95677 5-[(E)-2-cyclopropylethenyl]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 15 Platelet-derived growth factor subunit B Homo sapiens 11.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95677 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95677&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 49795816 164036921 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130104 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(NCC2CC2)c1 InChI=1S/C24H30N4O3/c1-15-6-9-17(23(30)27-20-4-2-3-5-22(20)29)11-21(15)28-24(31)18-10-19(14-25-13-18)26-12-16-7-8-16/h6,9-11,13-14,16,20,22,26,29H,2-5,7-8,12H2,1H3,(H,27,30)(H,28,31) DBKQXHRFOBDOAN-UHFFFAOYSA-N 95678 5-[(cyclopropylmethyl)amino]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 16 Platelet-derived growth factor subunit B Homo sapiens 22.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95678 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95678&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 355710 164036922 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130105 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(N(C)C2CC2)c1 InChI=1S/C24H30N4O3/c1-15-7-8-16(23(30)26-20-5-3-4-6-22(20)29)12-21(15)27-24(31)17-11-19(14-25-13-17)28(2)18-9-10-18/h7-8,11-14,18,20,22,29H,3-6,9-10H2,1-2H3,(H,26,30)(H,27,31) SZWDHWGKYZJWQK-UHFFFAOYSA-N 95679 5-[cyclopropyl(methyl)amino]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 17 Platelet-derived growth factor subunit B Homo sapiens 42.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95679&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2571013 164036923 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130106 COc1ccc(-c2cncc(C(=O)Nc3cc(C(=O)N[C@H]4CCCC[C@@H]4O)ccc3C)c2)cc1 InChI=1S/C27H29N3O4/c1-17-7-8-19(26(32)29-23-5-3-4-6-25(23)31)14-24(17)30-27(33)21-13-20(15-28-16-21)18-9-11-22(34-2)12-10-18/h7-16,23,25,31H,3-6H2,1-2H3,(H,29,32)(H,30,33) NPEPKMZVRQUZOP-UHFFFAOYSA-N 95680 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-(4-methoxyphenyl)pyridine-3-carboxamide::US12509424, Example 18 Platelet-derived growth factor subunit B Homo sapiens 39.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95680 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95680&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2094416 164036924 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130107 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccc(F)cc2)c1 InChI=1S/C26H26FN3O3/c1-16-6-7-18(25(32)29-22-4-2-3-5-24(22)31)13-23(16)30-26(33)20-12-19(14-28-15-20)17-8-10-21(27)11-9-17/h6-15,22,24,31H,2-5H2,1H3,(H,29,32)(H,30,33) BKAIHHQLWIVERC-UHFFFAOYSA-N 95681 5-(4-fluorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 19 Platelet-derived growth factor subunit B Homo sapiens 13.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95681 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95681&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2128937 164036925 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130108 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2cccc(F)c2)c1 InChI=1S/C26H26FN3O3/c1-16-9-10-18(25(32)29-22-7-2-3-8-24(22)31)13-23(16)30-26(33)20-11-19(14-28-15-20)17-5-4-6-21(27)12-17/h4-6,9-15,22,24,31H,2-3,7-8H2,1H3,(H,29,32)(H,30,33) IXBWJUPOVAZCSR-UHFFFAOYSA-N 95682 5-(3-fluorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 20 Platelet-derived growth factor subunit B Homo sapiens 13.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=95682 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=95682&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 989402 164036926 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130109 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccc(C(F)(F)F)cc2)c1 InChI=1S/C27H26F3N3O3/c1-16-6-7-18(25(35)32-22-4-2-3-5-24(22)34)13-23(16)33-26(36)20-12-19(14-31-15-20)17-8-10-21(11-9-17)27(28,29)30/h6-15,22,24,34H,2-5H2,1H3,(H,32,35)(H,33,36) YUKYUBOQNWFHRZ-UHFFFAOYSA-N 96240 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide::US12509424, Example 21 Platelet-derived growth factor subunit B Homo sapiens 73.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96240&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 659760 164037484 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130110 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2cccc(C(F)(F)F)c2)c1 InChI=1S/C27H26F3N3O3/c1-16-9-10-18(25(35)32-22-7-2-3-8-24(22)34)13-23(16)33-26(36)20-11-19(14-31-15-20)17-5-4-6-21(12-17)27(28,29)30/h4-6,9-15,22,24,34H,2-3,7-8H2,1H3,(H,32,35)(H,33,36) MVWKBAAQQXEOBG-UHFFFAOYSA-N 96241 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide::US12509424, Example 22 Platelet-derived growth factor subunit B Homo sapiens 14.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96241&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 6875617 164037485 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130111 CC(C)=Cc1cncc(C(=O)Nc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2C)c1 InChI=1S/C24H29N3O3/c1-15(2)10-17-11-19(14-25-13-17)24(30)27-21-12-18(9-8-16(21)3)23(29)26-20-6-4-5-7-22(20)28/h8-14,20,22,28H,4-7H2,1-3H3,(H,26,29)(H,27,30) ZADMSROMHGNNTB-UHFFFAOYSA-N 96242 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-(2-methylprop-1-en-1-yl)pyridine-3-carboxamide::US12509424, Example 23 Platelet-derived growth factor subunit B Homo sapiens 26.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96242&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5832601 164037486 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130112 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(OCC2CC2)c1 InChI=1S/C24H29N3O4/c1-15-6-9-17(23(29)26-20-4-2-3-5-22(20)28)11-21(15)27-24(30)18-10-19(13-25-12-18)31-14-16-7-8-16/h6,9-13,16,20,22,28H,2-5,7-8,14H2,1H3,(H,26,29)(H,27,30) RHELQXYPCFAWFR-UHFFFAOYSA-N 96243 5-(cyclopropylmethoxy)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 24 Platelet-derived growth factor subunit B Homo sapiens 64.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96243&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2608748 164037487 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130113 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NC2CC(F)(F)C2)s1 InChI=1S/C22H26F2N4O3S/c1-12-6-7-13(19(30)27-15-4-2-3-5-17(15)29)8-16(12)28-20(31)18-11-25-21(32-18)26-14-9-22(23,24)10-14/h6-8,11,14-15,17,29H,2-5,9-10H2,1H3,(H,25,26)(H,27,30)(H,28,31) BNVJRLUUTCVUSM-UHFFFAOYSA-N 96244 2-[(3,3-difluorocyclobutyl)amino]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-1,3-thiazole-5-carboxamide::US12509424, Example 25 Platelet-derived growth factor subunit B Homo sapiens 39.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96244&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 823976 164037488 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130114 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NCCC2CC2)s1 InChI=1S/C23H30N4O3S/c1-14-6-9-16(21(29)26-17-4-2-3-5-19(17)28)12-18(14)27-22(30)20-13-25-23(31-20)24-11-10-15-7-8-15/h6,9,12-13,15,17,19,28H,2-5,7-8,10-11H2,1H3,(H,24,25)(H,26,29)(H,27,30) RKMLEXGAEFOIJI-UHFFFAOYSA-N 96245 2-[(2-cyclopropylethyl)amino]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-1,3-thiazole-5-carboxamide::US12509424, Example 26 Platelet-derived growth factor subunit B Homo sapiens 4.60 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96245&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5395545 164037489 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130115 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NC(C)C)s1 InChI=1S/C21H28N4O3S/c1-12(2)23-21-22-11-18(29-21)20(28)25-16-10-14(9-8-13(16)3)19(27)24-15-6-4-5-7-17(15)26/h8-12,15,17,26H,4-7H2,1-3H3,(H,22,23)(H,24,27)(H,25,28) WBXYAHFZYYDBSA-UHFFFAOYSA-N 96246 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-2-[(propan-2-yl)amino]-1,3-thiazole-5-carboxamide::US12509424, Example 27 Platelet-derived growth factor subunit B Homo sapiens 8.30 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96246&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 9566733 164037490 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130116 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(OC2CCC(F)(F)CC2)c1 InChI=1S/C26H31F2N3O4/c1-16-6-7-17(24(33)30-21-4-2-3-5-23(21)32)13-22(16)31-25(34)18-12-20(15-29-14-18)35-19-8-10-26(27,28)11-9-19/h6-7,12-15,19,21,23,32H,2-5,8-11H2,1H3,(H,30,33)(H,31,34) HIWUYXJJMSRQLI-UHFFFAOYSA-N 96247 5-[(4,4-difluorocyclohexyl)oxy]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 28 Platelet-derived growth factor subunit B Homo sapiens 170 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96247&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5758733 164037491 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130117 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccccc2F)c1 InChI=1S/C26H26FN3O3/c1-16-10-11-17(25(32)29-22-8-4-5-9-24(22)31)13-23(16)30-26(33)19-12-18(14-28-15-19)20-6-2-3-7-21(20)27/h2-3,6-7,10-15,22,24,31H,4-5,8-9H2,1H3,(H,29,32)(H,30,33) XLLVMBSDZFLFAI-UHFFFAOYSA-N 96248 5-(2-fluorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 29 Platelet-derived growth factor subunit B Homo sapiens 35.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96248 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96248&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2865851 164037492 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130118 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2cccc(F)c2F)c1 InChI=1S/C26H25F2N3O3/c1-15-9-10-16(25(33)30-21-7-2-3-8-23(21)32)12-22(15)31-26(34)18-11-17(13-29-14-18)19-5-4-6-20(27)24(19)28/h4-6,9-14,21,23,32H,2-3,7-8H2,1H3,(H,30,33)(H,31,34) RVKZMMAMNRNZGG-UHFFFAOYSA-N 96249 5-(2,3-difluorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 30 Platelet-derived growth factor subunit B Homo sapiens 44.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96249&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 9566722 164037493 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130119 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccc(F)cc2F)c1 InChI=1S/C26H25F2N3O3/c1-15-6-7-16(25(33)30-22-4-2-3-5-24(22)32)11-23(15)31-26(34)18-10-17(13-29-14-18)20-9-8-19(27)12-21(20)28/h6-14,22,24,32H,2-5H2,1H3,(H,30,33)(H,31,34) OUQPOBYGTNUWGA-UHFFFAOYSA-N 96250 5-(2,4-difluorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 31 Platelet-derived growth factor subunit B Homo sapiens 73.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96250 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96250&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 9566735 164037494 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130120 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2cc(F)cc(F)c2)c1 InChI=1S/C26H25F2N3O3/c1-15-6-7-16(25(33)30-22-4-2-3-5-24(22)32)11-23(15)31-26(34)19-8-18(13-29-14-19)17-9-20(27)12-21(28)10-17/h6-14,22,24,32H,2-5H2,1H3,(H,30,33)(H,31,34) FOFKVHXHGURGAB-UHFFFAOYSA-N 96251 5-(3,5-difluorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 32 Platelet-derived growth factor subunit B Homo sapiens 47.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96251 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96251&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 12005460 164037495 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130121 COc1ccc(-c2cncc(C(=O)Nc3cc(C(=O)N[C@H]4CCCC[C@@H]4O)ccc3C)c2)c(F)c1 InChI=1S/C27H28FN3O4/c1-16-7-8-17(26(33)30-23-5-3-4-6-25(23)32)12-24(16)31-27(34)19-11-18(14-29-15-19)21-10-9-20(35-2)13-22(21)28/h7-15,23,25,32H,3-6H2,1-2H3,(H,30,33)(H,31,34) QSBNVRFAHBNONM-UHFFFAOYSA-N 96252 5-(2-fluoro-4-methoxyphenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 33 Platelet-derived growth factor subunit B Homo sapiens 19.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96252 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96252&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 6893438 164037496 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130122 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2cccc(OC(F)(F)F)c2)c1 InChI=1S/C27H26F3N3O4/c1-16-9-10-18(25(35)32-22-7-2-3-8-24(22)34)13-23(16)33-26(36)20-11-19(14-31-15-20)17-5-4-6-21(12-17)37-27(28,29)30/h4-6,9-15,22,24,34H,2-3,7-8H2,1H3,(H,32,35)(H,33,36) SSPGLWVXTCSTGU-UHFFFAOYSA-N 96253 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-[3-(trifluoromethoxy)phenyl]pyridine-3-carboxamide::US12509424, Example 34 Platelet-derived growth factor subunit B Homo sapiens 19.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96253&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 7207419 164037497 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130123 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccccc2OC(F)(F)F)c1 InChI=1S/C27H26F3N3O4/c1-16-10-11-17(25(35)32-21-7-3-4-8-23(21)34)13-22(16)33-26(36)19-12-18(14-31-15-19)20-6-2-5-9-24(20)37-27(28,29)30/h2,5-6,9-15,21,23,34H,3-4,7-8H2,1H3,(H,32,35)(H,33,36) CSGBKCWOCBYYEF-UHFFFAOYSA-N 96254 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-[2-(trifluoromethoxy)phenyl]pyridine-3-carboxamide::US12509424, Example 35 Platelet-derived growth factor subunit B Homo sapiens 160 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96254 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96254&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5434410 164037498 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130124 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccc(C(F)(F)F)cc2F)c1 InChI=1S/C27H25F4N3O3/c1-15-6-7-16(25(36)33-22-4-2-3-5-24(22)35)11-23(15)34-26(37)18-10-17(13-32-14-18)20-9-8-19(12-21(20)28)27(29,30)31/h6-14,22,24,35H,2-5H2,1H3,(H,33,36)(H,34,37) XATURMVEXWYYJQ-UHFFFAOYSA-N 96255 5-[2-fluoro-4-(trifluoromethyl)phenyl]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 36 Platelet-derived growth factor subunit B Homo sapiens 130 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96255&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 16189659 164037499 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130125 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2c(F)cccc2F)c1 InChI=1S/C26H25F2N3O3/c1-15-9-10-16(25(33)30-21-7-2-3-8-23(21)32)12-22(15)31-26(34)18-11-17(13-29-14-18)24-19(27)5-4-6-20(24)28/h4-6,9-14,21,23,32H,2-3,7-8H2,1H3,(H,30,33)(H,31,34) SIAFGISWBOOWQA-UHFFFAOYSA-N 96256 5-(2,6-difluorophenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 37 Platelet-derived growth factor subunit B Homo sapiens 33.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96256&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5763322 164037500 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130126 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NC(C)(C)C)s1 InChI=1S/C22H30N4O3S/c1-13-9-10-14(19(28)24-15-7-5-6-8-17(15)27)11-16(13)25-20(29)18-12-23-21(30-18)26-22(2,3)4/h9-12,15,17,27H,5-8H2,1-4H3,(H,23,26)(H,24,28)(H,25,29) RGBATUKNOWSFLK-UHFFFAOYSA-N 96257 2-(tert-butylamino)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-1,3-thiazole-5-carboxamide::US12509424, Example 38 Platelet-derived growth factor subunit B Homo sapiens 79.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96257&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 702695 164037501 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130127 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NC2(C)CC2)s1 InChI=1S/C22H28N4O3S/c1-13-7-8-14(19(28)24-15-5-3-4-6-17(15)27)11-16(13)25-20(29)18-12-23-21(30-18)26-22(2)9-10-22/h7-8,11-12,15,17,27H,3-6,9-10H2,1-2H3,(H,23,26)(H,24,28)(H,25,29) DZUIFFXMHUOGKH-UHFFFAOYSA-N 96258 N-(5-{[(1S,2S)-2-hydroxycyclohexylCcarbamoyl}-2-methylphenyl)-2-[(1-methylcyclopropyl)amino]-1,3-thiazole-5-carboxamide::N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-2-[(1-methylcyclopropyl)amino]-1,3-thiazole-5-carboxamide::US12509424, Example 39 Platelet-derived growth factor subunit B Homo sapiens 100.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96258 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96258&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 6901830 164037502 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130128 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NC2(C)CCC2)s1 InChI=1S/C23H30N4O3S/c1-14-8-9-15(20(29)25-16-6-3-4-7-18(16)28)12-17(14)26-21(30)19-13-24-22(31-19)27-23(2)10-5-11-23/h8-9,12-13,16,18,28H,3-7,10-11H2,1-2H3,(H,24,27)(H,25,29)(H,26,30) LXBDLRCLIFSWPA-UHFFFAOYSA-N 96259 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-2-[(1-methylcyclobutyl)amino]-1,3-thiazole-5-carboxamide::US12509424, Example 40 Platelet-derived growth factor subunit B Homo sapiens 43.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96259 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96259&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5405088 164037503 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130129 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(NCC(C)(C)C)s1 InChI=1S/C23H32N4O3S/c1-14-9-10-15(20(29)26-16-7-5-6-8-18(16)28)11-17(14)27-21(30)19-12-24-22(31-19)25-13-23(2,3)4/h9-12,16,18,28H,5-8,13H2,1-4H3,(H,24,25)(H,26,29)(H,27,30) DTTAPLXBZWKHCO-UHFFFAOYSA-N 96260 2-[(2,2-dimethylpropyl)amino]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-1,3-thiazole-5-carboxamide::US12509424, Example 41 Platelet-derived growth factor subunit B Homo sapiens 130 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96260&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5356520 164037504 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130130 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2cc(F)c(F)c(F)c2)c1 InChI=1S/C26H24F3N3O3/c1-14-6-7-15(25(34)31-21-4-2-3-5-23(21)33)11-22(14)32-26(35)18-8-17(12-30-13-18)16-9-19(27)24(29)20(28)10-16/h6-13,21,23,33H,2-5H2,1H3,(H,31,34)(H,32,35) WCVYFSLKWQDATA-UHFFFAOYSA-N 96261 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-(3,4,5-trifluorophenyl)pyridine-3-carboxamide::US12509424, Example 42 Platelet-derived growth factor subunit B Homo sapiens 230 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96261 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96261&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1994988 164037505 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130131 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(-c2ccc(C3CC3)cc2)c1 InChI=1S/C29H31N3O3/c1-18-6-7-22(28(34)31-25-4-2-3-5-27(25)33)15-26(18)32-29(35)24-14-23(16-30-17-24)21-12-10-20(11-13-21)19-8-9-19/h6-7,10-17,19,25,27,33H,2-5,8-9H2,1H3,(H,31,34)(H,32,35) TUWMNNLWYSYNFL-UHFFFAOYSA-N 96263 5-(4-cyclopropylphenyl)-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 43 Platelet-derived growth factor subunit B Homo sapiens 23.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96263 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96263&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 823973 164037507 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130132 O=C(Nc1cc(C(=O)N[C@H]2CCCC[C@@H]2O)ccc1Cl)c1cncc(OCC2CC2)c1 InChI=1S/C23H26ClN3O4/c24-18-8-7-15(22(29)26-19-3-1-2-4-21(19)28)10-20(18)27-23(30)16-9-17(12-25-11-16)31-13-14-5-6-14/h7-12,14,19,21,28H,1-6,13H2,(H,26,29)(H,27,30) ZYVWEFGRMZPAKZ-UHFFFAOYSA-N 96264 N-(2-chloro-5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}phenyl)-5-(cyclopropylmethoxy)pyridine-3-carboxamide::US12509424, Example 44 Platelet-derived growth factor subunit B Homo sapiens 190 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96264&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 762594 164037508 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130133 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc2sccn12 InChI=1S/C20H22N4O3S/c1-12-6-7-13(18(26)22-14-4-2-3-5-17(14)25)10-15(12)23-19(27)16-11-21-20-24(16)8-9-28-20/h6-11,14,17,25H,2-5H2,1H3,(H,22,26)(H,23,27) UYIRIGLEMGJEBP-UHFFFAOYSA-N 96265 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)imidazo[2,1-b][1,3]thiazole-5-carboxamide::US12509424, Example 45 Platelet-derived growth factor subunit B Homo sapiens 15.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96265 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96265&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 266468 164037509 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130134 Cc1c(F)cc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(OCC2CC2)c1 InChI=1S/C24H28FN3O4/c1-14-19(25)9-16(23(30)27-20-4-2-3-5-22(20)29)10-21(14)28-24(31)17-8-18(12-26-11-17)32-13-15-6-7-15/h8-12,15,20,22,29H,2-7,13H2,1H3,(H,27,30)(H,28,31) CGFCDCBUHZUJGY-UHFFFAOYSA-N 96266 5-(cyclopropylmethoxy)-N-(3-fluoro-5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 46 Platelet-derived growth factor subunit B Homo sapiens 77.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96266 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96266&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2871851 164037510 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130135 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(OC2CC(F)(F)C2)c1 InChI=1S/C24H27F2N3O4/c1-14-6-7-15(22(31)28-19-4-2-3-5-21(19)30)9-20(14)29-23(32)16-8-17(13-27-12-16)33-18-10-24(25,26)11-18/h6-9,12-13,18-19,21,30H,2-5,10-11H2,1H3,(H,28,31)(H,29,32) FLJFHVNYIWMJSQ-UHFFFAOYSA-N 96267 5-[(3,3-difluorocyclobutyl)oxy]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 47 Platelet-derived growth factor subunit B Homo sapiens 390 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96267 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96267&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 773976 164037511 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130136 Cc1c(F)cc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cnc(CC2CC2)s1 InChI=1S/C22H26FN3O3S/c1-12-15(23)9-14(21(28)25-16-4-2-3-5-18(16)27)10-17(12)26-22(29)19-11-24-20(30-19)8-13-6-7-13/h9-11,13,16,18,27H,2-8H2,1H3,(H,25,28)(H,26,29) OKMYUEOEUBYECS-UHFFFAOYSA-N 96268 2-(cyclopropylmethyl)-N-(3-fluoro-5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-1,3-thiazole-5-carboxamide::US12509424, Example 48 Platelet-derived growth factor subunit B Homo sapiens 120 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96268 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96268&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 8022634 164037512 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130137 COc1cncc(C(=O)Nc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2C)c1 InChI=1S/C21H25N3O4/c1-13-7-8-14(20(26)23-17-5-3-4-6-19(17)25)10-18(13)24-21(27)15-9-16(28-2)12-22-11-15/h7-12,17,19,25H,3-6H2,1-2H3,(H,23,26)(H,24,27) SLHAWMGSZDFSOG-UHFFFAOYSA-N 96270 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-methoxypyridine-3-carboxamide::US12509424, Example 49 Platelet-derived growth factor subunit B Homo sapiens 120 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96270 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96270&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1068705 164037514 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130138 CCOc1cncc(C(=O)Nc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2C)c1 InChI=1S/C22H27N3O4/c1-3-29-17-10-16(12-23-13-17)22(28)25-19-11-15(9-8-14(19)2)21(27)24-18-6-4-5-7-20(18)26/h8-13,18,20,26H,3-7H2,1-2H3,(H,24,27)(H,25,28) NWMQMVAWCYIEDU-UHFFFAOYSA-N 96271 5-ethoxy-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 50 Platelet-derived growth factor subunit B Homo sapiens 61.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96271 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96271&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1894659 164037515 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130139 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(Oc2ccccn2)c1 InChI=1S/C25H26N4O4/c1-16-9-10-17(24(31)28-20-6-2-3-7-22(20)30)13-21(16)29-25(32)18-12-19(15-26-14-18)33-23-8-4-5-11-27-23/h4-5,8-15,20,22,30H,2-3,6-7H2,1H3,(H,28,31)(H,29,32) JUXJHZBLBWIUTN-UHFFFAOYSA-N 96272 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-[(pyridin-2-yl)oxy]pyridine-3-carboxamide::US12509424, Example 51 Platelet-derived growth factor subunit B Homo sapiens 61.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96272 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96272&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5432756 164037516 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130140 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(Oc2ncccn2)c1 InChI=1S/C24H25N5O4/c1-15-7-8-16(22(31)28-19-5-2-3-6-21(19)30)12-20(15)29-23(32)17-11-18(14-25-13-17)33-24-26-9-4-10-27-24/h4,7-14,19,21,30H,2-3,5-6H2,1H3,(H,28,31)(H,29,32) MPBFYAHIQYJQHV-UHFFFAOYSA-N 96273 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-[(pyrimidin-2-yl)oxy]pyridine-3-carboxamide::US12509424, Example 52 Platelet-derived growth factor subunit B Homo sapiens 77.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96273 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96273&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 6902142 164037517 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130141 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(OCC2(C)CC2)c1 InChI=1S/C25H31N3O4/c1-16-7-8-17(23(30)27-20-5-3-4-6-22(20)29)12-21(16)28-24(31)18-11-19(14-26-13-18)32-15-25(2)9-10-25/h7-8,11-14,20,22,29H,3-6,9-10,15H2,1-2H3,(H,27,30)(H,28,31) QSDBHVKDLYYLEN-UHFFFAOYSA-N 96275 N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)-5-[(1-methylcyclopropyl)methoxy]pyridine-3-carboxamide::US12509424, Example 53 Platelet-derived growth factor subunit B Homo sapiens 12.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96275 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96275&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 15939 164037519 C00225 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130142 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NC(=O)c1cncc(OCC2CC(F)(F)C2)c1 InChI=1S/C25H29F2N3O4/c1-15-6-7-17(23(32)29-20-4-2-3-5-22(20)31)9-21(15)30-24(33)18-8-19(13-28-12-18)34-14-16-10-25(26,27)11-16/h6-9,12-13,16,20,22,31H,2-5,10-11,14H2,1H3,(H,29,32)(H,30,33) WJOFJLDURYBQNI-UHFFFAOYSA-N 96276 5-[(3,3-difluoroyclobutyl)methoxy]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::5-[(3,3-difluorocyclobutyl)methoxy]-N-(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylphenyl)pyridine-3-carboxamide::US12509424, Example 54 Platelet-derived growth factor subunit B Homo sapiens 40.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96276&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 555237 164037520 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130143 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(Cl)c(NC(=O)c2cnc(CC3CC3)s2)c1 InChI=1S/C21H24ClN3O3S/c22-14-8-7-13(20(27)24-15-3-1-2-4-17(15)26)10-16(14)25-21(28)18-11-23-19(29-18)9-12-5-6-12/h7-8,10-12,15,17,26H,1-6,9H2,(H,24,27)(H,25,28) FZDQJYWYPUIDOT-UHFFFAOYSA-N 96277 N-(2-chloro-5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}phenyl)-2-(cyclopropylmethyl)-1,3-thiazole-5-carboxamide::US12509424, Example 55 Platelet-derived growth factor subunit B Homo sapiens 83.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96277 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96277&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 314146 164037521 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130144 O=C(Nc1cc(C(=O)N[C@H]2CCCC[C@@H]2O)ccc1F)c1cncc(OCC2CC2)c1 InChI=1S/C23H26FN3O4/c24-18-8-7-15(22(29)26-19-3-1-2-4-21(19)28)10-20(18)27-23(30)16-9-17(12-25-11-16)31-13-14-5-6-14/h7-12,14,19,21,28H,1-6,13H2,(H,26,29)(H,27,30) ZWLSZKOHUFGMDC-UHFFFAOYSA-N 96278 5-(cyclopropylmethoxy)-N-(2-fluoro-5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}phenyl)pyridine-3-carboxamide::US12509424, Example 56 Platelet-derived growth factor subunit B Homo sapiens 120 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96278 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96278&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 42628318 164037522 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130145 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(Cl)c(C#Cc2cncc(Br)c2)c1 InChI=1S/C20H18BrClN2O2/c21-16-9-13(11-23-12-16)5-6-14-10-15(7-8-17(14)22)20(26)24-18-3-1-2-4-19(18)25/h7-12,18-19,25H,1-4H2,(H,24,26) RMEPIMTWUMSANW-UHFFFAOYSA-N 96279 3-[(5-bromopyridin-3-yl)ethynyl]-4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 57 Platelet-derived growth factor subunit B Homo sapiens 51.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96279 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96279&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 21013 164037523 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130146 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(Cl)c(C#Cc2cncc(-c3ccccc3)c2)c1 InChI=1S/C26H23ClN2O2/c27-23-13-12-21(26(31)29-24-8-4-5-9-25(24)30)15-20(23)11-10-18-14-22(17-28-16-18)19-6-2-1-3-7-19/h1-3,6-7,12-17,24-25,30H,4-5,8-9H2,(H,29,31) OOQROHBATSAKMK-UHFFFAOYSA-N 96280 4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]-3-[(5-phenylpyridin-3-yl)ethynyl]benzamide::US12509424, Example 58 Platelet-derived growth factor subunit B Homo sapiens 12.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96280 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96280&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 4852862 164037524 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130147 Cc1cncc(C#Cc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2C)c1 InChI=1S/C22H24N2O2/c1-15-11-17(14-23-13-15)8-10-18-12-19(9-7-16(18)2)22(26)24-20-5-3-4-6-21(20)25/h7,9,11-14,20-21,25H,3-6H2,1-2H3,(H,24,26) LNQDGMITKQGJDK-UHFFFAOYSA-N 96281 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[(5-methylpyridin-3-yl)ethynyl]benzamide::US12509424, Example 59 Platelet-derived growth factor subunit B Homo sapiens 210 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96281 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96281&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search XGF 8R0W 46380 164037525 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130148 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(-c2ccccc2)c1 InChI=1S/C27H26N2O2/c1-19-11-13-23(27(31)29-25-9-5-6-10-26(25)30)16-22(19)14-12-20-15-24(18-28-17-20)21-7-3-2-4-8-21/h2-4,7-8,11,13,15-18,25-26,30H,5-6,9-10H2,1H3,(H,29,31) ADNHQJGTCKQDAE-UHFFFAOYSA-N 96282 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[(5-phenylpyridin-3-yl)ethynyl]benzamide::US12509424, Example 60 Platelet-derived growth factor subunit B Homo sapiens 46.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96282 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96282&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 219997 164037526 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130149 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(Br)c1 InChI=1S/C21H21BrN2O2/c1-14-6-8-17(21(26)24-19-4-2-3-5-20(19)25)11-16(14)9-7-15-10-18(22)13-23-12-15/h6,8,10-13,19-20,25H,2-5H2,1H3,(H,24,26) BHPUTTBPNRLJAC-UHFFFAOYSA-N 96283 3-[(5-bromopyridin-3-yl)ethynyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 61 Platelet-derived growth factor subunit B Homo sapiens 41.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96283 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96283&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5829048 164037527 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130150 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(-c2ncccn2)c1 InChI=1S/C25H24N4O2/c1-17-7-9-20(25(31)29-22-5-2-3-6-23(22)30)14-19(17)10-8-18-13-21(16-26-15-18)24-27-11-4-12-28-24/h4,7,9,11-16,22-23,30H,2-3,5-6H2,1H3,(H,29,31) HGSPNRHXZDQBJF-UHFFFAOYSA-N 96284 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[5-(pyrimidin-2-yl)pyridin-3-yl]ethynyl}benzamide::US12509424, Example 62 Platelet-derived growth factor subunit B Homo sapiens 6.50 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96284 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96284&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 66122 164037528 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130151 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(-c2cnccn2)c1 InChI=1S/C25H24N4O2/c1-17-6-8-20(25(31)29-22-4-2-3-5-24(22)30)13-19(17)9-7-18-12-21(15-27-14-18)23-16-26-10-11-28-23/h6,8,10-16,22,24,30H,2-5H2,1H3,(H,29,31) CVVVDXZZAVNTTM-UHFFFAOYSA-N 96285 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[5-(pyrazin-2-yl)pyridin-3-yl]ethynyl}benzamide::US12509424, Example 63 Platelet-derived growth factor subunit B Homo sapiens 15.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96285 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96285&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 392857 164037529 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130152 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(Cl)c(C#Cc2cncc(-c3ncccn3)c2)c1 InChI=1S/C24H21ClN4O2/c25-20-9-8-18(24(31)29-21-4-1-2-5-22(21)30)13-17(20)7-6-16-12-19(15-26-14-16)23-27-10-3-11-28-23/h3,8-15,21-22,30H,1-2,4-5H2,(H,29,31) AYUHTTMULMTMLG-UHFFFAOYSA-N 96286 4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]-3-{[5-(pyrimidin-2-yl)pyridin-3-yl]ethynyl}benzamide::US12509424, Example 64 Platelet-derived growth factor subunit B Homo sapiens 260 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96286 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96286&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 496641 164037530 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130153 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1ccc(N)nc1 InChI=1S/C21H23N3O2/c1-14-6-9-17(21(26)24-18-4-2-3-5-19(18)25)12-16(14)10-7-15-8-11-20(22)23-13-15/h6,8-9,11-13,18-19,25H,2-5H2,1H3,(H2,22,23)(H,24,26) QNAJCGAYTAFQEO-UHFFFAOYSA-N 96287 3-[(6-aminopyridin-3-yl)ethynyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 65 Platelet-derived growth factor subunit B Homo sapiens 94.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96287 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96287&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 54608316 164037531 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130154 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(-c2ccccn2)c1 InChI=1S/C26H25N3O2/c1-18-9-11-21(26(31)29-24-7-2-3-8-25(24)30)15-20(18)12-10-19-14-22(17-27-16-19)23-6-4-5-13-28-23/h4-6,9,11,13-17,24-25,30H,2-3,7-8H2,1H3,(H,29,31) BPXMKCWDSUELKP-UHFFFAOYSA-N 96288 3-[([2,3'-bipyridin]-5'-yl)ethynyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 66 Platelet-derived growth factor subunit B Homo sapiens 5.40 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96288 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96288&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3613382 164037532 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130155 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(C2CC2)c1 InChI=1S/C24H26N2O2/c1-16-6-8-20(24(28)26-22-4-2-3-5-23(22)27)13-19(16)9-7-17-12-21(15-25-14-17)18-10-11-18/h6,8,12-15,18,22-23,27H,2-5,10-11H2,1H3,(H,26,28) VYLURXLSZNAHAF-UHFFFAOYSA-N 96289 3-[(5-cyclopropylpyridin-3-yl)ethynyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 67 Platelet-derived growth factor subunit B Homo sapiens 43.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96289 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96289&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 91899592 164037533 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130156 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(C2CC2)n1 InChI=1S/C23H25N3O2/c1-15-6-7-18(23(28)26-20-4-2-3-5-22(20)27)12-17(15)10-11-19-13-24-14-21(25-19)16-8-9-16/h6-7,12-14,16,20,22,27H,2-5,8-9H2,1H3,(H,26,28) PQXHUELUOGFAEQ-UHFFFAOYSA-N 96290 3-[(6-cyclopropylpyrazin-2-yl)ethynyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 68 Platelet-derived growth factor subunit B Homo sapiens 80.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96290 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96290&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3912236 164037534 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130157 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(-c2ccccc2F)n1 InChI=1S/C26H24FN3O2/c1-17-10-11-19(26(32)30-23-8-4-5-9-25(23)31)14-18(17)12-13-20-15-28-16-24(29-20)21-6-2-3-7-22(21)27/h2-3,6-7,10-11,14-16,23,25,31H,4-5,8-9H2,1H3,(H,30,32) IETZLYLFDXRFPH-UHFFFAOYSA-N 96292 3-{[6-(2-fluorophenyl)pyrazin-2-yl]ethynyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 69 Platelet-derived growth factor subunit B Homo sapiens 25.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96292 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96292&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 9556427 164037536 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130158 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(-c2cccc(F)c2)n1 InChI=1S/C26H24FN3O2/c1-17-9-10-20(26(32)30-23-7-2-3-8-25(23)31)13-18(17)11-12-22-15-28-16-24(29-22)19-5-4-6-21(27)14-19/h4-6,9-10,13-16,23,25,31H,2-3,7-8H2,1H3,(H,30,32) OXWNAOJSRPWYGL-UHFFFAOYSA-N 96293 3-{[6-(3-fluorophenyl)pyrazin-2-yl]ethynyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 70 Platelet-derived growth factor subunit B Homo sapiens 20.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96293 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96293&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 311899 164037537 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130159 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(-c2ccc(F)cc2)n1 InChI=1S/C26H24FN3O2/c1-17-6-7-20(26(32)30-23-4-2-3-5-25(23)31)14-19(17)10-13-22-15-28-16-24(29-22)18-8-11-21(27)12-9-18/h6-9,11-12,14-16,23,25,31H,2-5H2,1H3,(H,30,32) ANWUJLPQNMEXMJ-UHFFFAOYSA-N 96294 3-{[6-(4-fluorophenyl)pyrazin-2-yl]ethynyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 71 Platelet-derived growth factor subunit B Homo sapiens 42.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96294 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96294&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 313562 164037538 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130160 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(NCC2CC2)n1 InChI=1S/C24H28N4O2/c1-16-6-9-19(24(30)28-21-4-2-3-5-22(21)29)12-18(16)10-11-20-14-25-15-23(27-20)26-13-17-7-8-17/h6,9,12,14-15,17,21-22,29H,2-5,7-8,13H2,1H3,(H,26,27)(H,28,30) XYJXNYMTOLRKJN-UHFFFAOYSA-N 96295 3-({6-[(cyclopropylmethyl)amino]pyrazin-2-yl}ethynyl)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 72 Platelet-derived growth factor subunit B Homo sapiens 10.00 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96295 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96295&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 89851 164037539 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130161 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(C2CC2)c1 InChI=1S/C23H25N3O2/c1-15-18(7-6-16-10-19(13-24-12-16)17-8-9-17)11-20(14-25-15)23(28)26-21-4-2-3-5-22(21)27/h10-14,17,21-22,27H,2-5,8-9H2,1H3,(H,26,28) DLTSSZZDBQWRLF-UHFFFAOYSA-N 96297 5-[(5-cyclopropylpyridin-3-yl)ethynyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 73 Platelet-derived growth factor subunit B Homo sapiens 220 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96297 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96297&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 44887545 164037541 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130162 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(Br)n1 InChI=1S/C20H20BrN3O2/c1-13-6-7-15(20(26)24-17-4-2-3-5-18(17)25)10-14(13)8-9-16-11-22-12-19(21)23-16/h6-7,10-12,17-18,25H,2-5H2,1H3,(H,24,26) RTBWPDUMRNATLF-UHFFFAOYSA-N 96298 3-[(6-bromopyrazin-2-yl)ethynyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 74 Platelet-derived growth factor subunit B Homo sapiens 180 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96298 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96298&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5344250 164037542 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130163 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C#Cc1cncc(-c2ccccc2)n1 InChI=1S/C26H25N3O2/c1-18-11-12-21(26(31)29-23-9-5-6-10-25(23)30)15-20(18)13-14-22-16-27-17-24(28-22)19-7-3-2-4-8-19/h2-4,7-8,11-12,15-17,23,25,30H,5-6,9-10H2,1H3,(H,29,31) LMEQEQVQRPDDLO-UHFFFAOYSA-N 96299 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[(6-phenylpyrazin-2-yl)ethynyl]benzamide::US12509424, Example 75 Platelet-derived growth factor subunit B Homo sapiens 15.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96299 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96299&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 49790119 164037543 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130164 Cc1ccc(C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)cc1C#Cc1cncc(Br)c1 InChI=1S/C24H21BrN2O3/c1-16-7-9-20(12-19(16)10-8-17-11-21(25)14-26-13-17)24(30)27-22(15-28)23(29)18-5-3-2-4-6-18/h2-7,9,11-14,22-23,28-29H,15H2,1H3,(H,27,30) FKRGSUQKVCVBJS-UHFFFAOYSA-N 96300 3-[(5-bromopyridin-3-yl)ethynyl]-N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-4-methylbenzamide::US12509424, Example 76 Platelet-derived growth factor subunit B Homo sapiens 49.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96300 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96300&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 664069 164037544 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130165 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C(=O)Nc1cncc(-c2ccccc2)c1 InChI=1S/C26H27N3O3/c1-17-11-12-19(25(31)29-23-9-5-6-10-24(23)30)14-22(17)26(32)28-21-13-20(15-27-16-21)18-7-3-2-4-8-18/h2-4,7-8,11-16,23-24,30H,5-6,9-10H2,1H3,(H,28,32)(H,29,31) IXJJZHRFFXWLGF-UHFFFAOYSA-N 96301 N1-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-N3-(5-phenylpyridin-3-yl)benzene-1,3-dicarboxamide::US12509424, Example 77 Platelet-derived growth factor subunit B Homo sapiens 38.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96301 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96301&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 49792449 164037545 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130166 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1Nc1ccnc(-c2cccnc2)n1 InChI=1S/C23H25N5O2/c1-15-8-9-16(23(30)27-18-6-2-3-7-20(18)29)13-19(15)26-21-10-12-25-22(28-21)17-5-4-11-24-14-17/h4-5,8-14,18,20,29H,2-3,6-7H2,1H3,(H,27,30)(H,25,26,28) WDNXTCMGBBIQKE-UHFFFAOYSA-N 96302 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[2-(pyridin-3-yl)pyrimidin-4-yl]amino}benzamide::US12509424, Example 78 Platelet-derived growth factor subunit B Homo sapiens 51.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96302 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96302&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5985946 164037546 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130167 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1Nc1ccnc(-c2cncc3ccccc23)n1 InChI=1S/C27H27N5O2/c1-17-10-11-18(27(34)31-22-8-4-5-9-24(22)33)14-23(17)30-25-12-13-29-26(32-25)21-16-28-15-19-6-2-3-7-20(19)21/h2-3,6-7,10-16,22,24,33H,4-5,8-9H2,1H3,(H,31,34)(H,29,30,32) DISYWSAIFIIFAT-UHFFFAOYSA-N 96303 N-[(1S,2S)-2-hydroxycyclohexyl]-3-{[2-(isoquinolin-4-yl)pyrimidin-4-yl]amino}-4-methylbenzamide::US12509424, Example 79 Platelet-derived growth factor subunit B Homo sapiens 120 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96303 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96303&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 339703 164037547 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130168 Cc1ccc(C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)cc1Nc1ccnc(-c2cncc3ccccc23)n1 InChI=1S/C30H27N5O3/c1-19-11-12-21(30(38)34-26(18-36)28(37)20-7-3-2-4-8-20)15-25(19)33-27-13-14-32-29(35-27)24-17-31-16-22-9-5-6-10-23(22)24/h2-17,26,28,36-37H,18H2,1H3,(H,34,38)(H,32,33,35) KCEBKIZAWUXKHU-UHFFFAOYSA-N 96304 N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-3-{[2-(isoquinolin-4-yl)pyrimidin-4-yl]amino}-4-methylbenzamide::US12509424, Example 80 Platelet-derived growth factor subunit B Homo sapiens 120 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96304 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96304&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 292763 164037548 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130169 Cc1c(F)cc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1Nc1cccc(-c2cccnc2)n1 InChI=1S/C24H25FN4O2/c1-15-18(25)12-17(24(31)29-20-7-2-3-9-22(20)30)13-21(15)28-23-10-4-8-19(27-23)16-6-5-11-26-14-16/h4-6,8,10-14,20,22,30H,2-3,7,9H2,1H3,(H,27,28)(H,29,31) KAEZRXMMIJLZLM-UHFFFAOYSA-N 96305 3-[([2,3'-bipyridin]-6-yl)amino]-5-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 81 Platelet-derived growth factor subunit B Homo sapiens 190 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96305 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96305&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 340558 164037549 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130170 CNc1ncc2c(Nc3cc(C(=O)N[C@H]4CCCC[C@@H]4O)ccc3C)cccc2n1 InChI=1S/C23H27N5O2/c1-14-10-11-15(22(30)27-19-6-3-4-9-21(19)29)12-20(14)26-17-7-5-8-18-16(17)13-25-23(24-2)28-18/h5,7-8,10-13,19,21,26,29H,3-4,6,9H2,1-2H3,(H,27,30)(H,24,25,28) LAEFBYZHIZDBMK-UHFFFAOYSA-N 96306 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[2-(methylamino)quinazolin-5-yl]amino}benzamide::US12509424, Example 82 Platelet-derived growth factor subunit B Homo sapiens 27.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96306 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96306&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 355450 164037550 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130171 Cc1ccc(C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)cc1N1CCc2nc(N)ncc2C1 InChI=1S/C24H27N5O3/c1-15-7-8-17(23(32)27-20(14-30)22(31)16-5-3-2-4-6-16)11-21(15)29-10-9-19-18(13-29)12-26-24(25)28-19/h2-8,11-12,20,22,30-31H,9-10,13-14H2,1H3,(H,27,32)(H2,25,26,28) UQNOELAMYAXFQL-UHFFFAOYSA-N 96551 3-(2-amino-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-4-methylbenzamide::US12509424, Example 83 Platelet-derived growth factor subunit B Homo sapiens 5.00 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96551 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96551&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 646282 164037795 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130172 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1N[C@@H](C)c1cncc(-c2ccccc2)c1 InChI=1S/C27H31N3O2/c1-18-12-13-21(27(32)30-24-10-6-7-11-26(24)31)15-25(18)29-19(2)22-14-23(17-28-16-22)20-8-4-3-5-9-20/h3-5,8-9,12-17,19,24,26,29,31H,6-7,10-11H2,1-2H3,(H,30,32) IHSZZPOAPAWYCM-UHFFFAOYSA-N 96552 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(1S)-1-(5-phenylpyridin-3-yl)ethyl]amino}benzamide::US12509424, Example 84 Platelet-derived growth factor subunit B Homo sapiens 19.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96552 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96552&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 647153 164037796 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130173 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1N[C@@H](C)c1cncc(-c2cccnc2)c1 InChI=1S/C26H30N4O2/c1-17-9-10-19(26(32)30-23-7-3-4-8-25(23)31)13-24(17)29-18(2)21-12-22(16-28-15-21)20-6-5-11-27-14-20/h5-6,9-16,18,23,25,29,31H,3-4,7-8H2,1-2H3,(H,30,32) OTMGEKAULBJZSH-UHFFFAOYSA-N 96553 3-{[(1S)-1-([3,3'-bipyridin]-5-yl)ethyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 85 Platelet-derived growth factor subunit B Homo sapiens 180 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96553 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96553&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 650795 164037797 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130174 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1N[C@@H](C)c1cncc(C#Cc2ccccc2)c1 InChI=1S/C29H31N3O2/c1-20-12-15-24(29(34)32-26-10-6-7-11-28(26)33)17-27(20)31-21(2)25-16-23(18-30-19-25)14-13-22-8-4-3-5-9-22/h3-5,8-9,12,15-19,21,26,28,31,33H,6-7,10-11H2,1-2H3,(H,32,34) XTAYXIXEQYCAML-UHFFFAOYSA-N 96554 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({(1S)-1-[5-(phenylethynyl)pyridin-3-yl]ethyl}amino)benzamide::US12509424, Example 86 Platelet-derived growth factor subunit B Homo sapiens 230 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96554 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96554&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 650913 164037798 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130175 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1N[C@@H](C)c1cncc(-c2ccncc2)c1 InChI=1S/C26H30N4O2/c1-17-7-8-20(26(32)30-23-5-3-4-6-25(23)31)14-24(17)29-18(2)21-13-22(16-28-15-21)19-9-11-27-12-10-19/h7-16,18,23,25,29,31H,3-6H2,1-2H3,(H,30,32) DJOGVEZBCMLGSL-UHFFFAOYSA-N 96556 3-{[(1S)-1-([3,4'-bipyridin]-5-yl)ethyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 87 Platelet-derived growth factor subunit B Homo sapiens 250 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96556 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96556&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 654787 164037800 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130176 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1N[C@@H](C)c1cncc(-c2ncccn2)c1 InChI=1S/C25H29N5O2/c1-16-8-9-18(25(32)30-21-6-3-4-7-23(21)31)13-22(16)29-17(2)19-12-20(15-26-14-19)24-27-10-5-11-28-24/h5,8-15,17,21,23,29,31H,3-4,6-7H2,1-2H3,(H,30,32) NATBEKDRTYUYLD-UHFFFAOYSA-N 96557 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({(1S)-1-[5-(pyrimidin-2-yl)pyridin-3-yl]ethyl}amino)benzamide::US12509424, Example 88 Platelet-derived growth factor subunit B Homo sapiens 230 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96557 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96557&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 655353 164037801 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130177 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1N[C@@H](C)c1cncc(-c2ccccn2)c1 InChI=1S/C26H30N4O2/c1-17-10-11-19(26(32)30-23-8-3-4-9-25(23)31)14-24(17)29-18(2)20-13-21(16-27-15-20)22-7-5-6-12-28-22/h5-7,10-16,18,23,25,29,31H,3-4,8-9H2,1-2H3,(H,30,32) VRDGMAYGGCCYFF-UHFFFAOYSA-N 96558 3-{[(1S)-1-([2,3'-bipyridin]-5'-yl)ethyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 89 Platelet-derived growth factor subunit B Homo sapiens 78.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96558 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96558&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 100304 164037802 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130178 C[C@H](Nc1cc(C(=O)N[C@H]2CCCC[C@@H]2O)ccc1Cl)c1cncc(-c2cccnc2)c1 InChI=1S/C25H27ClN4O2/c1-16(19-11-20(15-28-14-19)18-5-4-10-27-13-18)29-23-12-17(8-9-21(23)26)25(32)30-22-6-2-3-7-24(22)31/h4-5,8-16,22,24,29,31H,2-3,6-7H2,1H3,(H,30,32) GCFFVRVLYNTWQD-UHFFFAOYSA-N 96560 3-{[(1S)-1-([3,3'-bipyridin]-5-yl)ethyl]amino}-4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 90 Platelet-derived growth factor subunit B Homo sapiens 310 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96560 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96560&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 658739 164037804 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130179 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(Br)c1 InChI=1S/C20H24BrN3O2/c1-13-6-7-15(20(26)24-17-4-2-3-5-19(17)25)9-18(13)23-11-14-8-16(21)12-22-10-14/h6-10,12,17,19,23,25H,2-5,11H2,1H3,(H,24,26) CDAMTJPBJGTZBV-UHFFFAOYSA-N 96561 3-{[(5-bromopyridin-3-yl)methyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 91 Platelet-derived growth factor subunit B Homo sapiens 150 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96561 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96561&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 659025 164037805 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130180 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2ccccc2)c1 InChI=1S/C26H29N3O2/c1-18-11-12-21(26(31)29-23-9-5-6-10-25(23)30)14-24(18)28-16-19-13-22(17-27-15-19)20-7-3-2-4-8-20/h2-4,7-8,11-15,17,23,25,28,30H,5-6,9-10,16H2,1H3,(H,29,31) XSJKUUPKFRFNGS-UHFFFAOYSA-N 96562 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(5-phenylpyridin-3-yl)methyl]amino}benzamide::US12509424, Example 92 Platelet-derived growth factor subunit B Homo sapiens 46.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96562 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96562&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 659574 164037806 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130181 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(-c2ccccn2)nc1 InChI=1S/C25H28N4O2/c1-17-9-11-19(25(31)29-22-7-2-3-8-24(22)30)14-23(17)28-16-18-10-12-21(27-15-18)20-6-4-5-13-26-20/h4-6,9-15,22,24,28,30H,2-3,7-8,16H2,1H3,(H,29,31) FUXFOORNJSWZEH-UHFFFAOYSA-N 96563 3-{[([2,2'-bipyridin]-5-yl)methyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 93 Platelet-derived growth factor subunit B Homo sapiens 360 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96563 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96563&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 664281 164037807 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130182 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(C#CC2CC2)c1 InChI=1S/C25H29N3O2/c1-17-6-11-21(25(30)28-22-4-2-3-5-24(22)29)13-23(17)27-16-20-12-19(14-26-15-20)10-9-18-7-8-18/h6,11-15,18,22,24,27,29H,2-5,7-8,16H2,1H3,(H,28,30) OMJWAMMBTARMLW-UHFFFAOYSA-N 96564 3-({[5-(cyclopropylethynyl)pyridin-3-yl]methyl}amino)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 94 Platelet-derived growth factor subunit B Homo sapiens 49.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96564 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96564&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 666160 164037808 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130183 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2ncccn2)c1 InChI=1S/C24H27N5O2/c1-16-7-8-18(24(31)29-20-5-2-3-6-22(20)30)12-21(16)28-14-17-11-19(15-25-13-17)23-26-9-4-10-27-23/h4,7-13,15,20,22,28,30H,2-3,5-6,14H2,1H3,(H,29,31) LLIGKEUCMRBVSN-UHFFFAOYSA-N 96565 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 95 Platelet-derived growth factor subunit B Homo sapiens 120 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96565 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96565&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1277315 164037809 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130184 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc2ccccc2c1 InChI=1S/C24H27N3O2/c1-16-10-11-19(24(29)27-21-8-4-5-9-23(21)28)13-22(16)26-15-17-12-18-6-2-3-7-20(18)25-14-17/h2-3,6-7,10-14,21,23,26,28H,4-5,8-9,15H2,1H3,(H,27,29) LEMQVKPRFLTPDL-UHFFFAOYSA-N 96566 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(quinolin-3-yl)methyl]amino}benzamide::US12509424, Example 96 Platelet-derived growth factor subunit B Homo sapiens 200 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96566 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96566&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2999954 164037810 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130185 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(C#CC2(O)CC2)c1 InChI=1S/C25H29N3O3/c1-17-6-7-20(24(30)28-21-4-2-3-5-23(21)29)13-22(17)27-16-19-12-18(14-26-15-19)8-9-25(31)10-11-25/h6-7,12-15,21,23,27,29,31H,2-5,10-11,16H2,1H3,(H,28,30) DOLZOISSGLFFCP-UHFFFAOYSA-N 96567 N-[(1S,2S)-2-hydroxycyclohexyl]-3-[({5-[(1-hydroxycyclopropyl)ethynyl]pyridin-3-yl}methyl)amino]-4-methylbenzamide::US12509424, Example 97 Platelet-derived growth factor subunit B Homo sapiens 100.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96567 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96567&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3238184 164037811 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130186 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2ccc(C(C)(C)N)cc2)c1 InChI=1S/C29H36N4O2/c1-19-8-9-22(28(35)33-25-6-4-5-7-27(25)34)15-26(19)32-17-20-14-23(18-31-16-20)21-10-12-24(13-11-21)29(2,3)30/h8-16,18,25,27,32,34H,4-7,17,30H2,1-3H3,(H,33,35) JOLKHRWMTBKYGU-UHFFFAOYSA-N 96568 3-[({5-[4-(2-aminopropan-2-yl)phenyl]pyridin-3-yl}methyl)amino]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 98 Platelet-derived growth factor subunit B Homo sapiens 140 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96568 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96568&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2921388 164037812 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130187 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2ccc(N)cc2)c1 InChI=1S/C26H30N4O2/c1-17-6-7-20(26(32)30-23-4-2-3-5-25(23)31)13-24(17)29-15-18-12-21(16-28-14-18)19-8-10-22(27)11-9-19/h6-14,16,23,25,29,31H,2-5,15,27H2,1H3,(H,30,32) WFANWTOKELUWBN-UHFFFAOYSA-N 96569 3-({[5-(4-aminophenyl)pyridin-3-yl]methyl}amino)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 99 Platelet-derived growth factor subunit B Homo sapiens 13.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96569 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96569&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3243102 164037813 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130188 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2cc(F)cc(F)c2)c1 InChI=1S/C26H27F2N3O2/c1-16-6-7-18(26(33)31-23-4-2-3-5-25(23)32)11-24(16)30-14-17-8-20(15-29-13-17)19-9-21(27)12-22(28)10-19/h6-13,15,23,25,30,32H,2-5,14H2,1H3,(H,31,33) YCZVEGSDYXXRPV-UHFFFAOYSA-N 96570 3-({[5-(3,5-difluorophenyl)pyridin-3-yl]methyl}amino)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 100 Platelet-derived growth factor subunit B Homo sapiens 32.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96570 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96570&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 91899607 164037814 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130189 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2ccccc2)n1 InChI=1S/C25H28N4O2/c1-17-11-12-19(25(31)29-21-9-5-6-10-24(21)30)13-22(17)27-15-20-14-26-16-23(28-20)18-7-3-2-4-8-18/h2-4,7-8,11-14,16,21,24,27,30H,5-6,9-10,15H2,1H3,(H,29,31) RGWHFINJTSYOLR-UHFFFAOYSA-N 96571 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(6-phenylpyrazin-2-yl)methyl]amino}benzamide::US12509424, Example 101 Platelet-derived growth factor subunit B Homo sapiens 170 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96571 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96571&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3243430 164037815 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130190 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2cccs2)c1 InChI=1S/C24H27N3O2S/c1-16-8-9-18(24(29)27-20-5-2-3-6-22(20)28)12-21(16)26-14-17-11-19(15-25-13-17)23-7-4-10-30-23/h4,7-13,15,20,22,26,28H,2-3,5-6,14H2,1H3,(H,27,29) RYYVTVXJYALHJP-UHFFFAOYSA-N 96572 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[5-(thiophen-2-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 102 Platelet-derived growth factor subunit B Homo sapiens 23.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96572 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96572&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3244329 164037816 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130191 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2ccsc2)c1 InChI=1S/C24H27N3O2S/c1-16-6-7-18(24(29)27-21-4-2-3-5-23(21)28)11-22(16)26-13-17-10-20(14-25-12-17)19-8-9-30-15-19/h6-12,14-15,21,23,26,28H,2-5,13H2,1H3,(H,27,29) GKZOUVCYHJHILN-UHFFFAOYSA-N 96573 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[5-(thiophen-3-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 103 Platelet-derived growth factor subunit B Homo sapiens 50.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96573 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96573&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1505949 164037817 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130192 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(Cl)c(NCc2cncc(-c3ncccn3)c2)c1 InChI=1S/C23H24ClN5O2/c24-18-7-6-16(23(31)29-19-4-1-2-5-21(19)30)11-20(18)28-13-15-10-17(14-25-12-15)22-26-8-3-9-27-22/h3,6-12,14,19,21,28,30H,1-2,4-5,13H2,(H,29,31) DPHDLEZWXFYEEN-UHFFFAOYSA-N 96574 4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 104 Platelet-derived growth factor subunit B Homo sapiens 260 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96574 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96574&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 378526 164037818 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130193 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnn2ccsc12 InChI=1S/C20H24N4O2S/c1-13-6-7-14(19(26)23-16-4-2-3-5-18(16)25)10-17(13)21-11-15-12-22-24-8-9-27-20(15)24/h6-10,12,16,18,21,25H,2-5,11H2,1H3,(H,23,26) XMOMEYJWCUYXCI-UHFFFAOYSA-N 96575 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(pyrazolo[5,1-b][1,3]thiazol-7-yl)methyl]amino}benzamide::US12509424, Example 105 Platelet-derived growth factor subunit B Homo sapiens 230 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96575 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96575&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2933024 164037819 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130194 Cc1c(F)cc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2ncccn2)c1 InChI=1S/C24H26FN5O2/c1-15-19(25)10-17(24(32)30-20-5-2-3-6-22(20)31)11-21(15)29-13-16-9-18(14-26-12-16)23-27-7-4-8-28-23/h4,7-12,14,20,22,29,31H,2-3,5-6,13H2,1H3,(H,30,32) OJORRMBKWJZKSQ-UHFFFAOYSA-N 96576 3-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-5-({[5-(pyrimidin-2-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 106 Platelet-derived growth factor subunit B Homo sapiens 67.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96576 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96576&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 748065 164037820 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130195 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2ncc(F)cn2)c1 InChI=1S/C24H26FN5O2/c1-15-6-7-17(24(32)30-20-4-2-3-5-22(20)31)9-21(15)27-11-16-8-18(12-26-10-16)23-28-13-19(25)14-29-23/h6-10,12-14,20,22,27,31H,2-5,11H2,1H3,(H,30,32) OAEANZDAJRMZES-UHFFFAOYSA-N 96577 3-({[5-(5-fluoropyrimidin-2-yl)pyridin-3-yl]methyl}amino)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 107 Platelet-derived growth factor subunit B Homo sapiens 190 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96577 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96577&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 756669 164037821 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130196 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc2ccsc2c1 InChI=1S/C22H25N3O2S/c1-14-6-7-16(22(27)25-17-4-2-3-5-20(17)26)11-19(14)24-13-15-10-21-18(23-12-15)8-9-28-21/h6-12,17,20,24,26H,2-5,13H2,1H3,(H,25,27) MJRKQRAZZBVBEY-UHFFFAOYSA-N 96578 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(thieno[3,2-b]pyridin-6-yl)methyl]amino}benzamide::US12509424, Example 108 Platelet-derived growth factor subunit B Homo sapiens 51.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96578 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96578&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 728246 164037822 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130197 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc2[nH]ncc2c1 InChI=1S/C21H25N5O2/c1-13-6-7-15(21(28)25-17-4-2-3-5-19(17)27)9-18(13)22-10-14-8-16-12-24-26-20(16)23-11-14/h6-9,11-12,17,19,22,27H,2-5,10H2,1H3,(H,25,28)(H,23,24,26) QFSKTOGQSARUSJ-UHFFFAOYSA-N 96579 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(1H-pyrazolo[3,4-b]pyridin-5-yl)methyl]amino}benzamide::US12509424, Example 109 Platelet-derived growth factor subunit B Homo sapiens 46.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96579 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96579&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2932916 164037823 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130198 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc2cccnn12 InChI=1S/C21H25N5O2/c1-14-8-9-15(21(28)25-17-5-2-3-6-19(17)27)11-18(14)22-12-16-13-23-20-7-4-10-24-26(16)20/h4,7-11,13,17,19,22,27H,2-3,5-6,12H2,1H3,(H,25,28) HIKHJDRNXWZKBQ-UHFFFAOYSA-N 96580 N-[(1S,2S)-2-hydroxycyclohexyl]-3-{[(imidazo[1,2-b]pyridazin-3-yl)methyl]amino}-4-methylbenzamide::US12509424, Example 110 Platelet-derived growth factor subunit B Homo sapiens 350 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96580 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96580&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3243125 164037824 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130199 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2cn3ccnc3cn2)c1 InChI=1S/C26H28N6O2/c1-17-6-7-19(26(34)31-21-4-2-3-5-24(21)33)11-22(17)29-13-18-10-20(14-27-12-18)23-16-32-9-8-28-25(32)15-30-23/h6-12,14-16,21,24,29,33H,2-5,13H2,1H3,(H,31,34) KILNXSOELHMKAI-UHFFFAOYSA-N 96581 N-[(1S,2S)-2-hydroxycyclohexyl]-3-({[5-(imidazo[1,2-a]pyrazin-6-yl)pyridin-3-yl]methyl}amino)-4-methylbenzamide::US12509424, Example 111 Platelet-derived growth factor subunit B Homo sapiens 150 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96581 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96581&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5310397 164037825 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130200 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnn(-c2ccccn2)c1 InChI=1S/C23H27N5O2/c1-16-9-10-18(23(30)27-19-6-2-3-7-21(19)29)12-20(16)25-13-17-14-26-28(15-17)22-8-4-5-11-24-22/h4-5,8-12,14-15,19,21,25,29H,2-3,6-7,13H2,1H3,(H,27,30) QRJCKEYENXBKOM-UHFFFAOYSA-N 96582 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[1-(pyridin-2-yl)-1H-pyrazol-4-yl]methyl}amino)benzamide::US12509424, Example 112 Platelet-derived growth factor subunit B Homo sapiens 39.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96582 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96582&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2900767 164037826 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130201 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc(N)nc1 InChI=1S/C19H25N5O2/c1-12-6-7-14(18(26)24-15-4-2-3-5-17(15)25)8-16(12)21-9-13-10-22-19(20)23-11-13/h6-8,10-11,15,17,21,25H,2-5,9H2,1H3,(H,24,26)(H2,20,22,23) NLBQJGCAVJSFSE-UHFFFAOYSA-N 96583 3-{[(2-aminopyrimidin-5-yl)methyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 113 Platelet-derived growth factor subunit B Homo sapiens 83.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96583 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96583&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 788462 164037827 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130202 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc(NC2CC2)nc1 InChI=1S/C22H29N5O2/c1-14-6-7-16(21(29)27-18-4-2-3-5-20(18)28)10-19(14)23-11-15-12-24-22(25-13-15)26-17-8-9-17/h6-7,10,12-13,17-18,20,23,28H,2-5,8-9,11H2,1H3,(H,27,29)(H,24,25,26) XOXVCUKZXLVSLE-UHFFFAOYSA-N 96584 3-({[2-(cyclopropylamino)pyrimidin-5-yl]methyl}amino)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 114 Platelet-derived growth factor subunit B Homo sapiens 270 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96584 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96584&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5340822 164037828 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130203 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-c2cnccn2)c1 InChI=1S/C24H27N5O2/c1-16-6-7-18(24(31)29-20-4-2-3-5-23(20)30)11-21(16)28-13-17-10-19(14-26-12-17)22-15-25-8-9-27-22/h6-12,14-15,20,23,28,30H,2-5,13H2,1H3,(H,29,31) JNYAHLWKOHBFQF-UHFFFAOYSA-N 96585 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[5-(pyrazin-2-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 115 Platelet-derived growth factor subunit B Homo sapiens 260 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96585 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96585&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2247137 164037829 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130204 CC(=O)Nc1ccc(CNc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2C)cn1 InChI=1S/C22H28N4O3/c1-14-7-9-17(22(29)26-18-5-3-4-6-20(18)28)11-19(14)23-12-16-8-10-21(24-13-16)25-15(2)27/h7-11,13,18,20,23,28H,3-6,12H2,1-2H3,(H,26,29)(H,24,25,27) LRWOMWONABPAQF-UHFFFAOYSA-N 96586 3-{[(6-acetamidopyridin-3-yl)methyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 116 Platelet-derived growth factor subunit B Homo sapiens 66.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96586 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96586&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2862533 164037830 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130205 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NCC2CC2)nc1 InChI=1S/C24H32N4O2/c1-16-6-10-19(24(30)28-20-4-2-3-5-22(20)29)12-21(16)25-14-18-9-11-23(27-15-18)26-13-17-7-8-17/h6,9-12,15,17,20,22,25,29H,2-5,7-8,13-14H2,1H3,(H,26,27)(H,28,30) DOMAFPANALRFEW-UHFFFAOYSA-N 96587 3-[({6-[(cyclopropylmethyl)amino]pyridin-3-yl}methyl)amino]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 117 Platelet-derived growth factor subunit B Homo sapiens 79.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96587 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96587&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 788520 164037831 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130206 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(-c2ccccn2)nc1 InChI=1S/C25H28N4O2/c1-17-9-11-19(25(31)29-22-7-2-3-8-24(22)30)14-23(17)28-16-18-10-12-21(27-15-18)20-6-4-5-13-26-20/h4-6,9-15,22,24,28,30H,2-3,7-8,16H2,1H3,(H,29,31) FUXFOORNJSWZEH-UHFFFAOYSA-N 96588 3-{[([2,2'-bipyridin]-5-yl)methyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 118 Platelet-derived growth factor subunit B Homo sapiens 390 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96588 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96588&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2304667 164037832 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130207 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnn2cccnc12 InChI=1S/C21H25N5O2/c1-14-7-8-15(21(28)25-17-5-2-3-6-19(17)27)11-18(14)23-12-16-13-24-26-10-4-9-22-20(16)26/h4,7-11,13,17,19,23,27H,2-3,5-6,12H2,1H3,(H,25,28) AEAIRDMRWLMALZ-UHFFFAOYSA-N 96590 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(pyrazolo[1,5-a]pyrimidin-3-yl)methyl]amino}benzamide::US12509424, Example 119 Platelet-derived growth factor subunit B Homo sapiens 330 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96590 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96590&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1814908 164037834 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130208 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC(=O)C2CC2)nc1 InChI=1S/C24H30N4O3/c1-15-6-8-18(24(31)27-19-4-2-3-5-21(19)29)12-20(15)25-13-16-7-11-22(26-14-16)28-23(30)17-9-10-17/h6-8,11-12,14,17,19,21,25,29H,2-5,9-10,13H2,1H3,(H,27,31)(H,26,28,30) IOHHSRGZGWNLDM-UHFFFAOYSA-N 96591 3-[({6-[(cyclopropanecarbonyl)amino]pyridin-3-yl}methyl)amino]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 120 Platelet-derived growth factor subunit B Homo sapiens 20.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96591 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96591&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 773666 164037835 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130209 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc(-c2ccccc2)nc1 InChI=1S/C25H28N4O2/c1-17-11-12-20(25(31)29-21-9-5-6-10-23(21)30)13-22(17)26-14-18-15-27-24(28-16-18)19-7-3-2-4-8-19/h2-4,7-8,11-13,15-16,21,23,26,30H,5-6,9-10,14H2,1H3,(H,29,31) SDECPHICPLDECK-UHFFFAOYSA-N 96592 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(2-phenylpyrimidin-5-yl)methyl]amino}benzamide::US12509424, Example 121 Platelet-derived growth factor subunit B Homo sapiens 160 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96592 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96592&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3222354 164037836 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130210 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(-n2cccn2)nc1 InChI=1S/C23H27N5O2/c1-16-7-9-18(23(30)27-19-5-2-3-6-21(19)29)13-20(16)24-14-17-8-10-22(25-15-17)28-12-4-11-26-28/h4,7-13,15,19,21,24,29H,2-3,5-6,14H2,1H3,(H,27,30) CBSNRULESRWPEL-UHFFFAOYSA-N 96593 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[6-(1H-pyrazol-1-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 122 Platelet-derived growth factor subunit B Homo sapiens 150 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96593 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96593&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3155914 164037837 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130211 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnn2ccccc12 InChI=1S/C21H25N5O2/c1-14-18(23-12-16-13-24-26-9-5-4-7-19(16)26)10-15(11-22-14)21(28)25-17-6-2-3-8-20(17)27/h4-5,7,9-11,13,17,20,23,27H,2-3,6,8,12H2,1H3,(H,25,28) KREKEHXCPYVQKH-UHFFFAOYSA-N 96594 N-[(1S,2S)-2-hydroxycyclohexyl]-6-methyl-5-{[(pyrazolofl,5-a]pyridin-3-yl)methyl]amino}pyridine-3-carboxamide::N-[(1S,2S)-2-hydroxycyclohexyl]-6-methyl-5-{[(pyrazolo[1,5-a]pyridin-3-yl)methyl]amino}pyridine-3-carboxamide::US12509424, Example 123 Platelet-derived growth factor subunit B Homo sapiens 210 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96594 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96594&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 818593 164037838 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130212 COC(=O)Nc1ccc(CNc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2C)cn1 InChI=1S/C22H28N4O4/c1-14-7-9-16(21(28)25-17-5-3-4-6-19(17)27)11-18(14)23-12-15-8-10-20(24-13-15)26-22(29)30-2/h7-11,13,17,19,23,27H,3-6,12H2,1-2H3,(H,25,28)(H,24,26,29) DXIWUXPWNKZPKR-UHFFFAOYSA-N 96595 methyl{5-[(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylanilino)methyl]pyridin-2-yl}carbamate::US12509424, Example 124 Platelet-derived growth factor subunit B Homo sapiens 22.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96595 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96595&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 36303 164037839 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130213 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC2CCOCC2)nc1 InChI=1S/C25H34N4O3/c1-17-6-8-19(25(31)29-21-4-2-3-5-23(21)30)14-22(17)26-15-18-7-9-24(27-16-18)28-20-10-12-32-13-11-20/h6-9,14,16,20-21,23,26,30H,2-5,10-13,15H2,1H3,(H,27,28)(H,29,31) PRXGMYDISOTWHI-UHFFFAOYSA-N 96596 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[({6-[(oxan-4-yl)amino]pyridin-3-yl}methyl)amino]benzamide::US12509424, Example 125 Platelet-derived growth factor subunit B Homo sapiens 130 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96596 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96596&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1816791 164037840 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130214 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc(Nc2ccccn2)nc1 InChI=1S/C24H28N6O2/c1-16-9-10-18(23(32)29-19-6-2-3-7-21(19)31)12-20(16)26-13-17-14-27-24(28-15-17)30-22-8-4-5-11-25-22/h4-5,8-12,14-15,19,21,26,31H,2-3,6-7,13H2,1H3,(H,29,32)(H,25,27,28,30) LUTDQJYCUFKTHM-UHFFFAOYSA-N 96597 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[({2-[(pyridin-2-yl)amino]pyrimidin-5-yl}methyl)amino]benzamide::US12509424, Example 126 Platelet-derived growth factor subunit B Homo sapiens 45.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96597 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96597&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1454452 164037841 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130215 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC(=O)N2CCOCC2)nc1 InChI=1S/C25H33N5O4/c1-17-6-8-19(24(32)28-20-4-2-3-5-22(20)31)14-21(17)26-15-18-7-9-23(27-16-18)29-25(33)30-10-12-34-13-11-30/h6-9,14,16,20,22,26,31H,2-5,10-13,15H2,1H3,(H,28,32)(H,27,29,33) HNYBZRPPRCCSOO-UHFFFAOYSA-N 96598 N-{5-[(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylanilino)methyl]pyridin-2-yl}morpholine-4-carboxamide::US12509424, Example 127 Platelet-derived growth factor subunit B Homo sapiens 63.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96598 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96598&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1205600 164037842 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130216 COc1ccc(-c2ncc(CNc3cc(C(=O)N[C@H]4CCCC[C@@H]4O)ccc3C)cn2)cc1 InChI=1S/C26H30N4O3/c1-17-7-8-20(26(32)30-22-5-3-4-6-24(22)31)13-23(17)27-14-18-15-28-25(29-16-18)19-9-11-21(33-2)12-10-19/h7-13,15-16,22,24,27,31H,3-6,14H2,1-2H3,(H,30,32) AVOPNDMMXGIWDS-UHFFFAOYSA-N 96599 N-[(1S,2S)-2-hydroxycyclohexyl]-3-({[2-(4-methoxyphenyl)pyrimidin-5-yl]methyl}amino)-4-methylbenzamide::US12509424, Example 128 Platelet-derived growth factor subunit B Homo sapiens 180 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96599 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96599&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1051125 164037843 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130217 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC(=O)Nc2cccnc2)nc1 InChI=1S/C26H30N6O3/c1-17-8-10-19(25(34)31-21-6-2-3-7-23(21)33)13-22(17)28-14-18-9-11-24(29-15-18)32-26(35)30-20-5-4-12-27-16-20/h4-5,8-13,15-16,21,23,28,33H,2-3,6-7,14H2,1H3,(H,31,34)(H2,29,30,32,35) ZSWOQLWELBEXIL-UHFFFAOYSA-N 96600 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(6-{[(pyridin-3-yl)carbamoyl]amino}pyridin-3-yl)methyl]amino}benzamide::US12509424, Example 129 Platelet-derived growth factor subunit B Homo sapiens 17.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96600 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96600&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 91899608 164037844 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130218 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC2CCC2)nc1 InChI=1S/C24H32N4O2/c1-16-9-11-18(24(30)28-20-7-2-3-8-22(20)29)13-21(16)25-14-17-10-12-23(26-15-17)27-19-5-4-6-19/h9-13,15,19-20,22,25,29H,2-8,14H2,1H3,(H,26,27)(H,28,30) NFZRJHOWVZKUGK-UHFFFAOYSA-N 96601 3-({[6-(cyclobutylamino)pyridin-3-yl]methyl}amino)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 130 Platelet-derived growth factor subunit B Homo sapiens 80.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96601 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96601&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 764949 164037845 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130219 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc(N)cn1 InChI=1S/C19H25N5O2/c1-12-6-7-13(19(26)24-15-4-2-3-5-17(15)25)8-16(12)22-9-14-10-23-18(20)11-21-14/h6-8,10-11,15,17,22,25H,2-5,9H2,1H3,(H2,20,23)(H,24,26) ISFVVHLNVFDALU-UHFFFAOYSA-N 96602 3-{[(5-aminopyrazin-2-yl)methyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 131 Platelet-derived growth factor subunit B Homo sapiens 490 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96602 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96602&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2132437 164037846 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130220 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1N(C)c1cnc(NC2CCOCC2)nc1 InChI=1S/C24H33N5O3/c1-16-7-8-17(23(31)28-20-5-3-4-6-22(20)30)13-21(16)29(2)19-14-25-24(26-15-19)27-18-9-11-32-12-10-18/h7-8,13-15,18,20,22,30H,3-6,9-12H2,1-2H3,(H,28,31)(H,25,26,27) KFWODZIPTQMPAB-UHFFFAOYSA-N 96603 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[({2-[(oxan-4-yl)amino]pyrimidin-5-yl[methyl)amino]benzamide::N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[2-[(oxan-4-yl)amino]pyrimidin-5-yl(methyl)amino]benzamide::US12509424, Example 132 Platelet-derived growth factor subunit B Homo sapiens 72.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96603 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96603&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 788460 164037847 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130221 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC(=O)N(C)C2CC2)nc1 InChI=1S/C25H33N5O3/c1-16-7-9-18(24(32)28-20-5-3-4-6-22(20)31)13-21(16)26-14-17-8-12-23(27-15-17)29-25(33)30(2)19-10-11-19/h7-9,12-13,15,19-20,22,26,31H,3-6,10-11,14H2,1-2H3,(H,28,32)(H,27,29,33) VATPMRUPHVYGQM-UHFFFAOYSA-N 96604 3-{[(6-{[cyclopropyl(methyl)carbamoyl]amino}pyridin-3-yl)methyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 133 Platelet-derived growth factor subunit B Homo sapiens 170 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96604 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96604&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 9568045 164037848 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130222 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC(C)C)nc1 InChI=1S/C23H32N4O2/c1-15(2)26-22-11-9-17(14-25-22)13-24-20-12-18(10-8-16(20)3)23(29)27-19-6-4-5-7-21(19)28/h8-12,14-15,19,21,24,28H,4-7,13H2,1-3H3,(H,25,26)(H,27,29) MACLXXUHOKYVIM-UHFFFAOYSA-N 96605 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[({6-[(propan-2-yl)amino]pyridin-3-yl}methyl)amino]benzamide::US12509424, Example 134 Platelet-derived growth factor subunit B Homo sapiens 170 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96605 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96605&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2747924 164037849 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130223 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc(N[C@@H]2CCOC2)nc1 InChI=1S/C23H31N5O3/c1-15-6-7-17(22(30)28-19-4-2-3-5-21(19)29)10-20(15)24-11-16-12-25-23(26-13-16)27-18-8-9-31-14-18/h6-7,10,12-13,18-19,21,24,29H,2-5,8-9,11,14H2,1H3,(H,28,30)(H,25,26,27) JGIWPQDBFQHZFT-UHFFFAOYSA-N 96606 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(2-{[(3R)-oxolan-3-yl]amino}pyrimidin-5-yl)methyl]amino}benzamide::US12509424, Example 135 Platelet-derived growth factor subunit B Homo sapiens 120 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96606 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96606&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 682184 164037850 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130224 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc(N[C@H]2CCOC2)nc1 InChI=1S/C23H31N5O3/c1-15-6-7-17(22(30)28-19-4-2-3-5-21(19)29)10-20(15)24-11-16-12-25-23(26-13-16)27-18-8-9-31-14-18/h6-7,10,12-13,18-19,21,24,29H,2-5,8-9,11,14H2,1H3,(H,28,30)(H,25,26,27) JGIWPQDBFQHZFT-UHFFFAOYSA-N 96607 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[(2-{[(3S)-oxolan-3-yl]amino}pyrimidin-5-yl)methyl]amino}benzamide::US12509424, Example 136 Platelet-derived growth factor subunit B Homo sapiens 32.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96607 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96607&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2932464 164037851 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130225 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC(=O)C2CCOCC2)nc1 InChI=1S/C26H34N4O4/c1-17-6-8-20(26(33)29-21-4-2-3-5-23(21)31)14-22(17)27-15-18-7-9-24(28-16-18)30-25(32)19-10-12-34-13-11-19/h6-9,14,16,19,21,23,27,31H,2-5,10-13,15H2,1H3,(H,29,33)(H,28,30,32) CILDQZQFROVEJL-UHFFFAOYSA-N 96608 N-{5-[(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylanilino)methyl]pyridin-2-yl}oxane-4-carboxamide::US12509424, Example 137 Platelet-derived growth factor subunit B Homo sapiens 41.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96608 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96608&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2850492 164037852 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130226 COC1CC(C(=O)Nc2ccc(CNc3cc(C(=O)N[C@H]4CCCC[C@@H]4O)ccc3C)cn2)C1 InChI=1S/C26H34N4O4/c1-16-7-9-18(25(32)29-21-5-3-4-6-23(21)31)13-22(16)27-14-17-8-10-24(28-15-17)30-26(33)19-11-20(12-19)34-2/h7-10,13,15,19-21,23,27,31H,3-6,11-12,14H2,1-2H3,(H,29,32)(H,28,30,33) BTVRAEJPDZPAKC-UHFFFAOYSA-N 96609 N-[(1S,2S)-2-hydroxycyclohexyl]-3-{[(6-{[(1r,3r)-3-methoxycyclobutane-1-carbonyl]amino}pyridin-3-yl)methyl]amino}-4-methylbenzamide::N-[(1S,2S)-2-hydroxycyclohexyl]-3-{[(6-{[3-methoxycyclobutane-1-carbonyl]amino}pyridin-3-yl)methyl]amino}-4-methylbenzamide::US12509424, Example 138 Platelet-derived growth factor subunit B Homo sapiens 16.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96609 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96609&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 795953 164037853 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130227 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC(=O)C2CCOC2)nc1 InChI=1S/C25H32N4O4/c1-16-6-8-18(24(31)28-20-4-2-3-5-22(20)30)12-21(16)26-13-17-7-9-23(27-14-17)29-25(32)19-10-11-33-15-19/h6-9,12,14,19-20,22,26,30H,2-5,10-11,13,15H2,1H3,(H,28,31)(H,27,29,32) HMGVWHYUGNYUDC-UHFFFAOYSA-N 96610 N-{5-[(5-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}-2-methylanilino)methyl]pyridin-2-yl}oxolane-3-carboxamide::US12509424, Example 139 Platelet-derived growth factor subunit B Homo sapiens 30.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96610 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96610&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3582921 164037854 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130228 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(-n2ccnn2)nc1 InChI=1S/C22H26N6O2/c1-15-6-8-17(22(30)26-18-4-2-3-5-20(18)29)12-19(15)23-13-16-7-9-21(24-14-16)28-11-10-25-27-28/h6-12,14,18,20,23,29H,2-5,13H2,1H3,(H,26,30) KWBMKNQJEKXJAM-UHFFFAOYSA-N 96611 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[6-(1H-1,2,3-triazol-1-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 140 Platelet-derived growth factor subunit B Homo sapiens 330 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96611 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96611&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 91899609 164037855 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130229 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1ccc(NC2COC2)nc1 InChI=1S/C23H30N4O3/c1-15-6-8-17(23(29)27-19-4-2-3-5-21(19)28)10-20(15)24-11-16-7-9-22(25-12-16)26-18-13-30-14-18/h6-10,12,18-19,21,24,28H,2-5,11,13-14H2,1H3,(H,25,26)(H,27,29) RYBGXPICORFJEA-UHFFFAOYSA-N 96612 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[({6-[(oxetan-3-yl)amino]pyridin-3-yl}methyl)amino]benzamide::US12509424, Example 141 Platelet-derived growth factor subunit B Homo sapiens 69.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96612 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96612&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1184246 164037856 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130230 Nc1ncc(CNc2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2Cl)cn1 InChI=1S/C18H22ClN5O2/c19-13-6-5-12(17(26)24-14-3-1-2-4-16(14)25)7-15(13)21-8-11-9-22-18(20)23-10-11/h5-7,9-10,14,16,21,25H,1-4,8H2,(H,24,26)(H2,20,22,23) PRFMNUZVFFWPQK-UHFFFAOYSA-N 96614 3-{[(2-aminopyrimidin-5-yl)methyl]amino}-4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 142 Platelet-derived growth factor subunit B Homo sapiens 210 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96614 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96614&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3590464 164037858 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130231 Cc1c(F)cc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc(N)nc1 InChI=1S/C19H24FN5O2/c1-11-14(20)6-13(18(27)25-15-4-2-3-5-17(15)26)7-16(11)22-8-12-9-23-19(21)24-10-12/h6-7,9-10,15,17,22,26H,2-5,8H2,1H3,(H,25,27)(H2,21,23,24) XZGXUWIDIUDBTK-UHFFFAOYSA-N 96615 3-{[(2-aminopyrirnidin-5-yl)methyl]amino}-5-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::3-{[(2-aminopyrimidin-5-yl)methyl]amino}-5-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 143 Platelet-derived growth factor subunit B Homo sapiens 97.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96615 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96615&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2954398 164037859 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130232 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cnc2c(c1)OCCN2 InChI=1S/C22H28N4O3/c1-14-6-7-16(22(28)26-17-4-2-3-5-19(17)27)11-18(14)24-12-15-10-20-21(25-13-15)23-8-9-29-20/h6-7,10-11,13,17,19,24,27H,2-5,8-9,12H2,1H3,(H,23,25)(H,26,28) XYRBAJAFLBWJAR-UHFFFAOYSA-N 96616 3-{[(3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-7-yl)methyl]amino}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 144 Platelet-derived growth factor subunit B Homo sapiens 65.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96616 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96616&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2142796 164037860 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130233 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1NCc1cncc(-n2nccn2)c1 InChI=1S/C22H26N6O2/c1-15-6-7-17(22(30)27-19-4-2-3-5-21(19)29)11-20(15)24-13-16-10-18(14-23-12-16)28-25-8-9-26-28/h6-12,14,19,21,24,29H,2-5,13H2,1H3,(H,27,30) AWNUDSABPYXKKF-UHFFFAOYSA-N 96617 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[5-(2H-1,2,3-triazol-2-yl)pyridin-3-yl]methyl}amino)benzamide::US12509424, Example 145 Platelet-derived growth factor subunit B Homo sapiens 100.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96617 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96617&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1825674 164037861 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130234 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1CNc1cncc(-c2cccnc2)c1 InChI=1S/C25H28N4O2/c1-17-8-9-18(25(31)29-23-6-2-3-7-24(23)30)11-20(17)15-28-22-12-21(14-27-16-22)19-5-4-10-26-13-19/h4-5,8-14,16,23-24,28,30H,2-3,6-7,15H2,1H3,(H,29,31) FVMPHLKPQHUCFX-UHFFFAOYSA-N 96618 3-{[([3,3'-bipyridin]-5-yl)amino]methyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 146 Platelet-derived growth factor subunit B Homo sapiens 210 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96618 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96618&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 4719684 164037862 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130235 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1CNc1cncc(-c2ncccn2)c1 InChI=1S/C24H27N5O2/c1-16-7-8-17(24(31)29-21-5-2-3-6-22(21)30)11-18(16)14-28-20-12-19(13-25-15-20)23-26-9-4-10-27-23/h4,7-13,15,21-22,28,30H,2-3,5-6,14H2,1H3,(H,29,31) IJYTYYDQYABMMS-UHFFFAOYSA-N 96619 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)benzamide::US12509424, Example 147 Platelet-derived growth factor subunit B Homo sapiens 24.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96619 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96619&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1792532 164037863 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130236 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1CNc1cncc(-c2ccccn2)c1 InChI=1S/C25H28N4O2/c1-17-9-10-18(25(31)29-23-7-2-3-8-24(23)30)12-19(17)15-28-21-13-20(14-26-16-21)22-6-4-5-11-27-22/h4-6,9-14,16,23-24,28,30H,2-3,7-8,15H2,1H3,(H,29,31) IUIHYQLTUKQADT-UHFFFAOYSA-N 96620 3-{[([2,3'-bipyridin]-5'-yl)amino]methyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 148 Platelet-derived growth factor subunit B Homo sapiens 16.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96620 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96620&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 11957167 164037864 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130237 Cc1ccc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1CNc1cncc(-c2ncccn2)c1 InChI=1S/C24H27N5O2/c1-16-7-8-17(24(31)29-21-5-2-3-6-22(21)30)11-18(16)14-28-20-12-19(13-25-15-20)23-26-9-4-10-27-23/h4,7-13,15,21-22,28,30H,2-3,5-6,14H2,1H3,(H,29,31) IJYTYYDQYABMMS-UHFFFAOYSA-N 96621 N-[(1R,2R)-2-hydroxycyclohexyl]-4-methyl-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)benzamide::US12509424, Example 149 Platelet-derived growth factor subunit B Homo sapiens 220 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96621 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96621&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 6863844 164037865 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130238 O=C(N[C@H]1CCCC[C@@H]1O)c1cccc(CNc2cncc(-c3ncccn3)c2)c1 InChI=1S/C23H25N5O2/c29-21-8-2-1-7-20(21)28-23(30)17-6-3-5-16(11-17)13-27-19-12-18(14-24-15-19)22-25-9-4-10-26-22/h3-6,9-12,14-15,20-21,27,29H,1-2,7-8,13H2,(H,28,30) RTSUDJUFMICFHM-UHFFFAOYSA-N 96622 N-[(1S,2S)-2-hydroxycyclohexyl]-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)benzamide::US12509424, Example 150 Platelet-derived growth factor subunit B Homo sapiens 360 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96622 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96622&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 91899610 164037866 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130239 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(CNc2cncc(-c3ncccn3)c2)c1 InChI=1S/C23H24FN5O2/c24-19-7-6-15(23(31)29-20-4-1-2-5-21(20)30)10-16(19)13-28-18-11-17(12-25-14-18)22-26-8-3-9-27-22/h3,6-12,14,20-21,28,30H,1-2,4-5,13H2,(H,29,31) KLSWWVOSENDHID-UHFFFAOYSA-N 96623 4-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)benzamide::US12509424, Example 151 Platelet-derived growth factor subunit B Homo sapiens 170 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96623 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96623&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 11958560 164037867 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130240 Cc1ccc(C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)cc1CNc1cncc(Br)c1 InChI=1S/C23H24BrN3O3/c1-15-7-8-17(9-18(15)11-26-20-10-19(24)12-25-13-20)23(30)27-21(14-28)22(29)16-5-3-2-4-6-16/h2-10,12-13,21-22,26,28-29H,11,14H2,1H3,(H,27,30) YHYNKLLGCSCKSN-UHFFFAOYSA-N 96624 3-{[(5-bromopyridin-3-yl)amino]methyl}-N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-4-methylbenzamide::US12509424, Example 152 Platelet-derived growth factor subunit B Homo sapiens 50.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96624 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96624&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3114586 164037868 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130241 Cc1ccc(C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)cc1CNc1cncc(-c2ccccc2)c1 InChI=1S/C29H29N3O3/c1-20-12-13-23(29(35)32-27(19-33)28(34)22-10-6-3-7-11-22)14-24(20)17-31-26-15-25(16-30-18-26)21-8-4-2-5-9-21/h2-16,18,27-28,31,33-34H,17,19H2,1H3,(H,32,35) FHSJSWABEGVNEG-UHFFFAOYSA-N 96625 N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-4-methyl-3-{[(5-phenylpyridin-3-yl)amino]methyl[benzamide::N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-4-methyl-3-{[(5-phenylpyridin-3-yl)amino]methyl}benzamide::US12509424, Example 153 Platelet-derived growth factor subunit B Homo sapiens 88.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96625 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96625&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1151719 164037869 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130242 Cc1ccc(C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)cc1CNc1cncc(C2CC2)c1 InChI=1S/C26H29N3O3/c1-17-7-8-20(26(32)29-24(16-30)25(31)19-5-3-2-4-6-19)11-21(17)14-28-23-12-22(13-27-15-23)18-9-10-18/h2-8,11-13,15,18,24-25,28,30-31H,9-10,14,16H2,1H3,(H,29,32) OWPGQQIOAFQFCM-UHFFFAOYSA-N 96626 3-{[(5-cyclopropylpyridin-3-yl)amino]methyl}-N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-4-methylbenzamide::US12509424, Example 154 Platelet-derived growth factor subunit B Homo sapiens 340 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96626 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96626&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2873240 164037870 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130243 Cc1ccc(C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)cc1CNc1cncc(-c2ccccn2)c1 InChI=1S/C28H28N4O3/c1-19-10-11-21(28(35)32-26(18-33)27(34)20-7-3-2-4-8-20)13-22(19)16-31-24-14-23(15-29-17-24)25-9-5-6-12-30-25/h2-15,17,26-27,31,33-34H,16,18H2,1H3,(H,32,35) XSIDAVMCRRBOHT-UHFFFAOYSA-N 96627 3-{[([2,3'-bipyridin]-5'-yl)amino]methyl}-N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-4-methylbenzamide::US12509424, Example 155 Platelet-derived growth factor subunit B Homo sapiens 36.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96627 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96627&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1723513 164037871 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130244 Cc1ccc(C(=O)N[C@@H](CO)[C@@H](O)c2ccccc2)cc1CNc1cncc(-c2ccccc2)n1 InChI=1S/C28H28N4O3/c1-19-12-13-22(28(35)32-25(18-33)27(34)21-10-6-3-7-11-21)14-23(19)15-30-26-17-29-16-24(31-26)20-8-4-2-5-9-20/h2-14,16-17,25,27,33-34H,15,18H2,1H3,(H,30,31)(H,32,35) JUVOWMBZLYMXMW-UHFFFAOYSA-N 96628 N-[(1S,2S)-1,3-dihydroxy-1-phenylpropan-2-yl]-4-methyl-3-{[(6-phenylpyrazin-2-yl)amino]methyl}benzamide::US12509424, Example 156 Platelet-derived growth factor subunit B Homo sapiens 25.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96628 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96628&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 230117 164037872 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130245 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1CNc1cncc(C#CC2CC2)c1 InChI=1S/C24H28N4O2/c1-16-19(13-27-21-10-18(12-25-15-21)9-8-17-6-7-17)11-20(14-26-16)24(30)28-22-4-2-3-5-23(22)29/h10-12,14-15,17,22-23,27,29H,2-7,13H2,1H3,(H,28,30) SLHIAUFNJYEVKC-UHFFFAOYSA-N 96629 5-({[5-(cyclopropylethynyl)pyridin-3-yl]amino}methyl)-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 157 Platelet-derived growth factor subunit B Homo sapiens 180 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96629 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96629&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 153617 164037873 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130246 COc1ccc(-c2cncc(NCc3cccc(NC(=O)N[C@@H]4CCCC[C@@H]4O)c3)n2)cc1OC InChI=1S/C26H31N5O4/c1-34-23-11-10-18(13-24(23)35-2)21-15-27-16-25(30-21)28-14-17-6-5-7-19(12-17)29-26(33)31-20-8-3-4-9-22(20)32/h5-7,10-13,15-16,20,22,32H,3-4,8-9,14H2,1-2H3,(H,28,30)(H2,29,31,33) GUOFUFQLSRPWON-UHFFFAOYSA-N 96630 N-[3-({[6-(3,4-dimcthoxyphenyl)pyrazin-2-yl]amino}methyl)phenyl]-N'-[(1R,2S)-2-hydroxycyclohexyl]urea::N-[3-({[6-(3,4-dimethoxyphenyl)pyrazin-2-yl]amino}methyl)phenyl]-N'-[(1R,2S)-2-hydroxycyclohexyl]urea::US12509424, Example 158 Platelet-derived growth factor subunit B Homo sapiens 26.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96630 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96630&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 91899611 164037874 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130247 O=C(Nc1cccc(CNc2cncc(-c3ncccn3)c2)c1)N[C@@H]1CCCC[C@@H]1O InChI=1S/C23H26N6O2/c30-21-8-2-1-7-20(21)29-23(31)28-18-6-3-5-16(11-18)13-27-19-12-17(14-24-15-19)22-25-9-4-10-26-22/h3-6,9-12,14-15,20-21,27,30H,1-2,7-8,13H2,(H2,28,29,31) ARWSLXWWOVEDJU-UHFFFAOYSA-N 96631 N-[(1R,2S)-2-hydroxycyclohexyl]-N'-[3-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)phenyl]urea::US12509424, Example 159 Platelet-derived growth factor subunit B Homo sapiens 26.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96631 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96631&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2817882 164037875 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130248 O=C(Nc1cc(CNc2cncc(-c3ncccn3)c2)ccc1F)N[C@@H]1CCCC[C@@H]1O InChI=1S/C23H25FN6O2/c24-18-7-6-15(10-20(18)30-23(32)29-19-4-1-2-5-21(19)31)12-28-17-11-16(13-25-14-17)22-26-8-3-9-27-22/h3,6-11,13-14,19,21,28,31H,1-2,4-5,12H2,(H2,29,30,32) ODBPUGQMQCYUIL-UHFFFAOYSA-N 96632 N-[2-fluoro-5-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)phenyl]-N'-[(1R,2S)-2-hydroxycyclohexyl]urea::US12509424, Example 160 Platelet-derived growth factor subunit B Homo sapiens 46.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96632 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96632&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 4304978 164037876 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130249 O=C(Nc1ccc(F)c(CNc2cncc(-c3ncccn3)c2)c1)N[C@@H]1CCCC[C@@H]1O InChI=1S/C23H25FN6O2/c24-19-7-6-17(29-23(32)30-20-4-1-2-5-21(20)31)10-15(19)13-28-18-11-16(12-25-14-18)22-26-8-3-9-27-22/h3,6-12,14,20-21,28,31H,1-2,4-5,13H2,(H2,29,30,32) MTYHYRHECBFIOS-UHFFFAOYSA-N 96633 N-[4-fluoro-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)phenyl]-N'-[(1R,2S)-2-hydroxycyclohexyl]urea::US12509424, Example 161 Platelet-derived growth factor subunit B Homo sapiens 16.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96633 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96633&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3663845 164037877 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130250 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@@H]2O)cc1CNc1cncc(-c2ncccn2)c1 InChI=1S/C24H28N6O2/c1-16-7-8-19(29-24(32)30-21-5-2-3-6-22(21)31)11-17(16)14-28-20-12-18(13-25-15-20)23-26-9-4-10-27-23/h4,7-13,15,21-22,28,31H,2-3,5-6,14H2,1H3,(H2,29,30,32) DSQBZBWSNUNGLP-UHFFFAOYSA-N 96634 N-[(1R,2S)-2-hydroxycyclohexyl]-N'-[4-methyl-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)phenyl]urea::US12509424, Example 162 Platelet-derived growth factor subunit B Homo sapiens 2.60 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96634 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96634&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3697926 164037878 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130251 Cc1ccc(CNc2cncc(-c3ncccn3)c2)cc1NC(=O)N[C@@H]1CCCC[C@@H]1O InChI=1S/C24H28N6O2/c1-16-7-8-17(11-21(16)30-24(32)29-20-5-2-3-6-22(20)31)13-28-19-12-18(14-25-15-19)23-26-9-4-10-27-23/h4,7-12,14-15,20,22,28,31H,2-3,5-6,13H2,1H3,(H2,29,30,32) XLRXNKZKNNTDLF-UHFFFAOYSA-N 96635 N-[(1R,2S)-2-hydroxycyclohexyl]-N'-[2-methyl-5-({[5-(pyrimidin-2-yl)pyridin-3-yl]amino}methyl)phenyl]urea::US12509424, Example 163 Platelet-derived growth factor subunit B Homo sapiens 260 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96635 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96635&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 751700 164037879 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130252 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1C(C)Nc1cncc(-c2ccccc2)n1 InChI=1S/C26H30N4O2/c1-17-12-13-20(26(32)30-22-10-6-7-11-24(22)31)14-21(17)18(2)28-25-16-27-15-23(29-25)19-8-4-3-5-9-19/h3-5,8-9,12-16,18,22,24,31H,6-7,10-11H2,1-2H3,(H,28,29)(H,30,32) HDVKXIXQDYGQRP-UHFFFAOYSA-N 96636 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{1-[(6-phenylpyrazin-2-yl)amino]ethyl}benzamide::US12509424, Example 164 Platelet-derived growth factor subunit B Homo sapiens 110 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96636 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96636&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 980466 164037880 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130253 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1OCc1cncc(-c2cccnc2)c1 InChI=1S/C25H27N3O3/c1-17-8-9-19(25(30)28-22-6-2-3-7-23(22)29)12-24(17)31-16-18-11-21(15-27-13-18)20-5-4-10-26-14-20/h4-5,8-15,22-23,29H,2-3,6-7,16H2,1H3,(H,28,30) CDVHYKMTLCQXSS-UHFFFAOYSA-N 96637 3-[([3,3'-bipyridin]-5-yl)methoxy]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 165 Platelet-derived growth factor subunit B Homo sapiens 390 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96637 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96637&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3119442 164037881 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130254 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1OCc1cncc(-c2ncccn2)c1 InChI=1S/C24H26N4O3/c1-16-7-8-18(24(30)28-20-5-2-3-6-21(20)29)12-22(16)31-15-17-11-19(14-25-13-17)23-26-9-4-10-27-23/h4,7-14,20-21,29H,2-3,5-6,15H2,1H3,(H,28,30) XTCVGEAFQOINIY-UHFFFAOYSA-N 96638 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[5-(pyrimidin-2-yl)pyridin-3-yl]methoxy}benzamide::US12509424, Example 166 Platelet-derived growth factor subunit B Homo sapiens 49.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96638 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96638&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 9562792 164037882 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130255 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(Cl)c(OCc2cncc(-c3ncccn3)c2)c1 InChI=1S/C23H23ClN4O3/c24-18-7-6-16(23(30)28-19-4-1-2-5-20(19)29)11-21(18)31-14-15-10-17(13-25-12-15)22-26-8-3-9-27-22/h3,6-13,19-20,29H,1-2,4-5,14H2,(H,28,30) ZMHHMVODHCDODH-UHFFFAOYSA-N 96639 4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]-3-{[5-(pyrimidin-2-yl)pyridin-3-yl]methoxy}benzamide::US12509424, Example 167 Platelet-derived growth factor subunit B Homo sapiens 210 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96639 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96639&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 9621982 164037883 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130256 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1COc1cncc(-c2cccnc2)c1 InChI=1S/C25H27N3O3/c1-17-8-9-18(25(30)28-23-6-2-3-7-24(23)29)11-21(17)16-31-22-12-20(14-27-15-22)19-5-4-10-26-13-19/h4-5,8-15,23-24,29H,2-3,6-7,16H2,1H3,(H,28,30) JRLCCEOHACVAOF-UHFFFAOYSA-N 96640 3-{[([3,3'-bipyridin]-5-yl)oxy]methyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 168 Platelet-derived growth factor subunit B Homo sapiens 350 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96640 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96640&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3621166 164037884 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130257 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1COc1cncc(-c2ncccn2)c1 InChI=1S/C24H26N4O3/c1-16-7-8-17(24(30)28-21-5-2-3-6-22(21)29)11-19(16)15-31-20-12-18(13-25-14-20)23-26-9-4-10-27-23/h4,7-14,21-22,29H,2-3,5-6,15H2,1H3,(H,28,30) IBNMUGRKORVAAW-UHFFFAOYSA-N 96641 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]oxy}methyl)benzamide::US12509424, Example 169 Platelet-derived growth factor subunit B Homo sapiens 52.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96641 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96641&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 4458727 164037885 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130258 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(Cl)c(COc2cncc(-c3ncccn3)c2)c1 InChI=1S/C23H23ClN4O3/c24-19-7-6-15(23(30)28-20-4-1-2-5-21(20)29)10-17(19)14-31-18-11-16(12-25-13-18)22-26-8-3-9-27-22/h3,6-13,20-21,29H,1-2,4-5,14H2,(H,28,30) WZJIQHNGUZFHGA-UHFFFAOYSA-N 96642 4-chloro-N-[(1S,2S)-2-hydroxycyclohexyl]-3-({[5-(pyrimidin-2-yl)pyridin-3-yl]oxy}methyl)benzamide::US12509424, Example 170 Platelet-derived growth factor subunit B Homo sapiens 200 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96642 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96642&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 5031940 164037886 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130259 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1OC(C)c1cncc(-c2ncccn2)c1 InChI=1S/C25H28N4O3/c1-16-8-9-18(25(31)29-21-6-3-4-7-22(21)30)13-23(16)32-17(2)19-12-20(15-26-14-19)24-27-10-5-11-28-24/h5,8-15,17,21-22,30H,3-4,6-7H2,1-2H3,(H,29,31) RQPFFKLGQLSBCR-UHFFFAOYSA-N 96643 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{1-[5-(pyrimidin-2-yl)pyridin-3-yl]ethoxy}benzamide::US12509424, Example 171 Platelet-derived growth factor subunit B Homo sapiens 260 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96643 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96643&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3628641 164037887 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130260 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1OC(C)c1cncc(-c2ccccc2)c1 InChI=1S/C27H30N2O3/c1-18-12-13-21(27(31)29-24-10-6-7-11-25(24)30)15-26(18)32-19(2)22-14-23(17-28-16-22)20-8-4-3-5-9-20/h3-5,8-9,12-17,19,24-25,30H,6-7,10-11H2,1-2H3,(H,29,31) ZJSNFKHPSYJZRG-UHFFFAOYSA-N 96645 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[1-(5-phenylpyridin-3-yl)ethoxy]benzamide::US12509424, Example 172 Platelet-derived growth factor subunit B Homo sapiens 190 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96645 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96645&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 12006196 164037889 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130261 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C/c1cncc(-c2ccccc2)c1 InChI=1S/C27H28N2O2/c1-19-11-13-23(27(31)29-25-9-5-6-10-26(25)30)16-22(19)14-12-20-15-24(18-28-17-20)21-7-3-2-4-8-21/h2-4,7-8,11-18,25-26,30H,5-6,9-10H2,1H3,(H,29,31) JUSBOFZJUYWORR-UHFFFAOYSA-N 96646 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[(E)-2-(5-phenylpyridin-3-yl)ethenyl]benzamide::US12509424, Example 173 Platelet-derived growth factor subunit B Homo sapiens 54.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96646 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96646&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 4132674 164037890 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130262 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1CCc1cncc(-c2ccccc2)c1 InChI=1S/C27H30N2O2/c1-19-11-13-23(27(31)29-25-9-5-6-10-26(25)30)16-22(19)14-12-20-15-24(18-28-17-20)21-7-3-2-4-8-21/h2-4,7-8,11,13,15-18,25-26,30H,5-6,9-10,12,14H2,1H3,(H,29,31) SMPUFSPYCJZBJD-UHFFFAOYSA-N 96647 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-[2-(5-phenylpyridin-3-yl)ethyl]benzamide::US12509424, Example 174 Platelet-derived growth factor subunit B Homo sapiens 27.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96647 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96647&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2887253 164037891 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130263 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1CN(C)c1cncc(-c2ccccc2)c1 InChI=1S/C27H31N3O2/c1-19-12-13-21(27(32)29-25-10-6-7-11-26(25)31)14-23(19)18-30(2)24-15-22(16-28-17-24)20-8-4-3-5-9-20/h3-5,8-9,12-17,25-26,31H,6-7,10-11,18H2,1-2H3,(H,29,32) MHPQGSJYSIRWQC-UHFFFAOYSA-N 96648 N-[(1S,2S)-2-hydroxycyclohexyl]-4-methyl-3-{[methyl(5-phenylpyridin-3-yl)amino]methyl}benzamide::US12509424, Example 175 Platelet-derived growth factor subunit B Homo sapiens 24.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96648 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96648&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1936567 164037892 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130264 CCN(Cc1cc(C(=O)N[C@H]2CCCC[C@@H]2O)ccc1C)c1cncc(-c2ccccc2)c1 InChI=1S/C28H33N3O2/c1-3-31(25-16-23(17-29-18-25)21-9-5-4-6-10-21)19-24-15-22(14-13-20(24)2)28(33)30-26-11-7-8-12-27(26)32/h4-6,9-10,13-18,26-27,32H,3,7-8,11-12,19H2,1-2H3,(H,30,33) UPEDXEWMRRFWOH-UHFFFAOYSA-N 96649 3-{[ethyl(5-phenylpyridin-3-yl)amino]methyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 176 Platelet-derived growth factor subunit B Homo sapiens 50.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96649 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96649&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 4875223 164037893 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130265 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(/C=C(\F)c2cncc(-c3ccccn3)c2)c1 InChI=1S/C25H23F2N3O2/c26-20-9-8-16(25(32)30-23-6-1-2-7-24(23)31)11-17(20)13-21(27)18-12-19(15-28-14-18)22-5-3-4-10-29-22/h3-5,8-15,23-24,31H,1-2,6-7H2,(H,30,32) CLEBSKWXAAVMSM-UHFFFAOYSA-N 96650 3-[(Z)-2-([2,3'-bipyridin]-5'-yl)-2-fluoroethenyl]-4-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 177 Platelet-derived growth factor subunit B Homo sapiens 15.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96650 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96650&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 675055 164037894 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130266 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(/C=C(\F)c2cncc(-c3ncccn3)c2)c1 InChI=1S/C24H22F2N4O2/c25-19-7-6-15(24(32)30-21-4-1-2-5-22(21)31)10-16(19)12-20(26)17-11-18(14-27-13-17)23-28-8-3-9-29-23/h3,6-14,21-22,31H,1-2,4-5H2,(H,30,32) MUMSJQCEOQLPNH-UHFFFAOYSA-N 96651 4-fluoro-3-{(Z)-2-fluoro-2-[5-(pyrimidin-2-yl)pyridin-3-yl]ethenyl}-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 178 Platelet-derived growth factor subunit B Homo sapiens 26.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96651 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96651&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 996225 164037895 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130267 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cnc2cccnn12 InChI=1S/C22H23FN4O2/c1-14-8-9-15(22(29)26-18-5-2-3-6-20(18)28)11-16(14)12-17(23)19-13-24-21-7-4-10-25-27(19)21/h4,7-13,18,20,28H,2-3,5-6H2,1H3,(H,26,29) HSYTWKNDRNJDNI-UHFFFAOYSA-N 96652 3-[(Z)-2-fluoro-2-(imidazo[1,2-b]pyridazin-3-yl)ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 179 Platelet-derived growth factor subunit B Homo sapiens 5.90 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96652 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96652&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2525976 164037896 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130268 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cncc(-c2ccccn2)c1 InChI=1S/C25H25FN4O2/c1-16-17(10-20(15-29-16)25(32)30-23-7-2-3-8-24(23)31)12-21(26)18-11-19(14-27-13-18)22-6-4-5-9-28-22/h4-6,9-15,23-24,31H,2-3,7-8H2,1H3,(H,30,32) HTQOTJOTRQQBLM-UHFFFAOYSA-N 96653 5-[(Z)-2-([2,3'-bipyridin]-5'-yl)-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 180 Platelet-derived growth factor subunit B Homo sapiens 16.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96653 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96653&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 15945446 164037897 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130269 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cncc(CN2CCN(C)CC2)c1 InChI=1S/C27H35FN4O2/c1-19-7-8-21(27(34)30-25-5-3-4-6-26(25)33)14-22(19)15-24(28)23-13-20(16-29-17-23)18-32-11-9-31(2)10-12-32/h7-8,13-17,25-26,33H,3-6,9-12,18H2,1-2H3,(H,30,34) SHPFBJKMDTYVEV-UHFFFAOYSA-N 96654 3-[(Z)-2-fluoro-2-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 181 Platelet-derived growth factor subunit B Homo sapiens 100.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96654 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96654&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1233817 164037898 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130270 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cncc(CN2CCOCC2)c1 InChI=1S/C26H32FN3O3/c1-18-6-7-20(26(32)29-24-4-2-3-5-25(24)31)13-21(18)14-23(27)22-12-19(15-28-16-22)17-30-8-10-33-11-9-30/h6-7,12-16,24-25,31H,2-5,8-11,17H2,1H3,(H,29,32) PNXUXCOHYWPJRG-UHFFFAOYSA-N 96655 3-[(Z)-2-fluoro-2-{5-[(morpholin-4-yl)methyl]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 182 Platelet-derived growth factor subunit B Homo sapiens 33.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96655 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96655&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 6508103 164037899 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130271 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1ccc(NCC2CC2)nc1 InChI=1S/C25H30FN3O2/c1-16-6-9-18(25(31)29-22-4-2-3-5-23(22)30)12-20(16)13-21(26)19-10-11-24(28-15-19)27-14-17-7-8-17/h6,9-13,15,17,22-23,30H,2-5,7-8,14H2,1H3,(H,27,28)(H,29,31) XBWUYAICSDOZTM-UHFFFAOYSA-N 96656 3-[(Z)-2-{6-[(cyclopropylmethyl)amino]pyridin-3-yl}-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 183 Platelet-derived growth factor subunit B Homo sapiens 30.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96656 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96656&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 56620 164037900 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130272 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(/C=C(\F)c2cncc(N3CCOCC3)c2)c1 InChI=1S/C24H27F2N3O3/c25-20-6-5-16(24(31)28-22-3-1-2-4-23(22)30)11-17(20)13-21(26)18-12-19(15-27-14-18)29-7-9-32-10-8-29/h5-6,11-15,22-23,30H,1-4,7-10H2,(H,28,31) ZFVSQZFESMQBKD-UHFFFAOYSA-N 96657 4-fluoro-3-{(Z)-2-fluoro-2-[5-(morpholin-4-yl)pyridin-3-yl]ethenyl}-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 184 Platelet-derived growth factor subunit B Homo sapiens 51.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96657 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96657&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2894351 164037901 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130273 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(/C=C(\F)c2cncc(NC3CCOCC3)c2)c1 InChI=1S/C25H29F2N3O3/c26-21-6-5-16(25(32)30-23-3-1-2-4-24(23)31)11-17(21)13-22(27)18-12-20(15-28-14-18)29-19-7-9-33-10-8-19/h5-6,11-15,19,23-24,29,31H,1-4,7-10H2,(H,30,32) HGDXLMWTJVVXRJ-UHFFFAOYSA-N 96658 4-fluoro-3-[(Z)-2-fluoro-2-{5-[(oxan-4-yl)amino]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 185 Platelet-derived growth factor subunit B Homo sapiens 5.10 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96658 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96658&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1816795 164037902 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130274 CN1CCN(Cc2cncc(/C(F)=C/c3cc(C(=O)N[C@H]4CCCC[C@@H]4O)ccc3F)c2)CC1 InChI=1S/C26H32F2N4O2/c1-31-8-10-32(11-9-31)17-18-12-21(16-29-15-18)23(28)14-20-13-19(6-7-22(20)27)26(34)30-24-4-2-3-5-25(24)33/h6-7,12-16,24-25,33H,2-5,8-11,17H2,1H3,(H,30,34) KCFDYFOJLPYUQM-UHFFFAOYSA-N 96659 4-fluoro-3-[(Z)-2-fluoro-2-{5-[(4-methylpiperazm4-yl)methyl]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::4-fluoro-3-[(Z)-2-fluoro-2-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 186 Platelet-derived growth factor subunit B Homo sapiens 150 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96659 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96659&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2939328 164037903 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130275 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cncc(OCC2CC2)c1 InChI=1S/C24H28FN3O3/c1-15-17(8-19(12-27-15)24(30)28-22-4-2-3-5-23(22)29)10-21(25)18-9-20(13-26-11-18)31-14-16-6-7-16/h8-13,16,22-23,29H,2-7,14H2,1H3,(H,28,30) XFKNINBEFVNBJE-UHFFFAOYSA-N 96660 5-{(Z)-2-[5-(cyclopropylmethoxy)pyridin-3-yl]-2-fluoroethenyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 187 Platelet-derived growth factor subunit B Homo sapiens 14.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96660 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96660&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3201682 164037904 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130276 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cncc(N2CCOCC2)c1 InChI=1S/C24H29FN4O3/c1-16-17(10-19(14-27-16)24(31)28-22-4-2-3-5-23(22)30)12-21(25)18-11-20(15-26-13-18)29-6-8-32-9-7-29/h10-15,22-23,30H,2-9H2,1H3,(H,28,31) LTTJBJURFFZTAP-UHFFFAOYSA-N 96661 5-{(Z)-2-fluoro-2-[5-(morpholin-4-yl)pyridin-3-yl]ethenyl}-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 188 Platelet-derived growth factor subunit B Homo sapiens 68.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96661 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96661&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 91899612 164037905 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130277 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1ccc(N)nc1 InChI=1S/C20H23FN4O2/c1-12-14(9-16(21)13-6-7-19(22)24-10-13)8-15(11-23-12)20(27)25-17-4-2-3-5-18(17)26/h6-11,17-18,26H,2-5H2,1H3,(H2,22,24)(H,25,27) VYCOXCJJLYBGMS-UHFFFAOYSA-N 96662 5-[(Z)-2-(6-aminopyridin-3-yl)-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 189 Platelet-derived growth factor subunit B Homo sapiens 200 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96662 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96662&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 16188232 164037906 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130278 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cnc(N)nc1 InChI=1S/C19H22FN5O2/c1-11-12(7-15(20)14-9-23-19(21)24-10-14)6-13(8-22-11)18(27)25-16-4-2-3-5-17(16)26/h6-10,16-17,26H,2-5H2,1H3,(H,25,27)(H2,21,23,24) UKFUIHRLZHYYNH-UHFFFAOYSA-N 96663 5-[(Z)-2-(2-aminopyrimidin-5-yl)-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 190 Platelet-derived growth factor subunit B Homo sapiens 110 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96663 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96663&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 893906 164037907 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130279 Nc1ccc(/C(F)=C/c2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2F)cn1 InChI=1S/C20H21F2N3O2/c21-15-7-5-12(20(27)25-17-3-1-2-4-18(17)26)9-14(15)10-16(22)13-6-8-19(23)24-11-13/h5-11,17-18,26H,1-4H2,(H2,23,24)(H,25,27) WTVILZVNQUHFRW-UHFFFAOYSA-N 96664 3-[(Z)-2-(6-aminopyridin-3-yl)-2-fluoroethenyl]-4-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 191 Platelet-derived growth factor subunit B Homo sapiens 35.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96664 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96664&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 9652638 164037908 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130280 Nc1ncc(/C(F)=C/c2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2F)cn1 InChI=1S/C19H20F2N4O2/c20-14-6-5-11(18(27)25-16-3-1-2-4-17(16)26)7-12(14)8-15(21)13-9-23-19(22)24-10-13/h5-10,16-17,26H,1-4H2,(H,25,27)(H2,22,23,24) TYGBHQPBFXMZQC-UHFFFAOYSA-N 96665 3-[(Z)-2-(2-aminopyrimidin-5-yl)-2-fluoroethenyl]-4-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 192 Platelet-derived growth factor subunit B Homo sapiens 29.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96665 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96665&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 16188541 164037909 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130281 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cncc(NC2CCN(C)CC2)c1 InChI=1S/C27H35FN4O2/c1-18-7-8-19(27(34)31-25-5-3-4-6-26(25)33)13-20(18)15-24(28)21-14-23(17-29-16-21)30-22-9-11-32(2)12-10-22/h7-8,13-17,22,25-26,30,33H,3-6,9-12H2,1-2H3,(H,31,34) PCSSOFWIYQZDGK-UHFFFAOYSA-N 96666 3-[(Z)-2-fluoro-2-{5-[(1-methylpiperidin-4-yl)amino]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 193 Platelet-derived growth factor subunit B Homo sapiens 1.000 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96666 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96666&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 16188681 164037910 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130282 CCN1CCN(Cc2cncc(/C(F)=C/c3cc(C(=O)N[C@H]4CCCC[C@@H]4O)ccc3C)c2)CC1 InChI=1S/C28H37FN4O2/c1-3-32-10-12-33(13-11-32)19-21-14-24(18-30-17-21)25(29)16-23-15-22(9-8-20(23)2)28(35)31-26-6-4-5-7-27(26)34/h8-9,14-18,26-27,34H,3-7,10-13,19H2,1-2H3,(H,31,35) QZQIPMUSANVLCK-UHFFFAOYSA-N 96667 3-[(Z)-2-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-3-yl}-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 194 Platelet-derived growth factor subunit B Homo sapiens 35.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96667 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96667&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 1307868 164037911 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130283 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cncc(NC2COC2)c1 InChI=1S/C23H27FN4O3/c1-14-15(6-17(10-26-14)23(30)28-21-4-2-3-5-22(21)29)8-20(24)16-7-18(11-25-9-16)27-19-12-31-13-19/h6-11,19,21-22,27,29H,2-5,12-13H2,1H3,(H,28,30) GBBNUOZPMGJAEQ-UHFFFAOYSA-N 96668 5-[(Z)-2-fluoro-2-{5-[(oxetan-3-yl)amino]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 195 Platelet-derived growth factor subunit B Homo sapiens 19.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96668 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96668&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3131752 164037912 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130284 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(/C=C(\F)c2cncc(NC3COC3)c2)c1 InChI=1S/C23H25F2N3O3/c24-19-6-5-14(23(30)28-21-3-1-2-4-22(21)29)7-15(19)9-20(25)16-8-17(11-26-10-16)27-18-12-31-13-18/h5-11,18,21-22,27,29H,1-4,12-13H2,(H,28,30) QWHXVEMPHHFIMA-UHFFFAOYSA-N 96669 4-fluoro-3-[(Z)-2-fluoro-2-{5-[(oxetan-3-yl)amino]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 196 Platelet-derived growth factor subunit B Homo sapiens 26.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96669 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96669&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2324818 164037913 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130285 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1ccc(NCCN(C)C)nc1 InChI=1S/C25H33FN4O2/c1-17-8-9-18(25(32)29-22-6-4-5-7-23(22)31)14-20(17)15-21(26)19-10-11-24(28-16-19)27-12-13-30(2)3/h8-11,14-16,22-23,31H,4-7,12-13H2,1-3H3,(H,27,28)(H,29,32) PWDWXBMPIJQASI-UHFFFAOYSA-N 96670 3-[(Z)-2-(6-{[2-(dimethylamino)ethyl]amino}pyridin-3-yl)-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 197 Platelet-derived growth factor subunit B Homo sapiens 120 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96670 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96670&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2930673 164037914 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130286 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cncc(NCCN(C)C)c1 InChI=1S/C25H33FN4O2/c1-17-8-9-18(25(32)29-23-6-4-5-7-24(23)31)12-19(17)14-22(26)20-13-21(16-27-15-20)28-10-11-30(2)3/h8-9,12-16,23-24,28,31H,4-7,10-11H2,1-3H3,(H,29,32) MEKUBQYAJAOREX-UHFFFAOYSA-N 96671 3-[(Z)-2-(5-{[2-(dimethylamino)ethyl]amino}pyridin-3-yl)-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 198 Platelet-derived growth factor subunit B Homo sapiens 7.20 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96671 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96671&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2214948 164037915 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130287 Cc1ncc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1ccc(NCC2CC2)nc1 InChI=1S/C24H29FN4O2/c1-15-18(10-19(14-26-15)24(31)29-21-4-2-3-5-22(21)30)11-20(25)17-8-9-23(28-13-17)27-12-16-6-7-16/h8-11,13-14,16,21-22,30H,2-7,12H2,1H3,(H,27,28)(H,29,31) GYVLFTGJPOFJKL-UHFFFAOYSA-N 96672 5-[(Z)-2-{6-[(cyclopropylmethyl)amino]pyridin-3-yl}-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-6-methylpyridine-3-carboxamide::US12509424, Example 199 Platelet-derived growth factor subunit B Homo sapiens 52.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96672 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96672&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2976696 164037916 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130288 Cc1ccc(C(=O)N[C@H]2c3ccccc3C[C@@H]2O)cc1/C=C(\F)c1cncc(CN2CCN(C)CC2)c1 InChI=1S/C30H33FN4O2/c1-20-7-8-23(30(37)33-29-26-6-4-3-5-22(26)16-28(29)36)14-24(20)15-27(31)25-13-21(17-32-18-25)19-35-11-9-34(2)10-12-35/h3-8,13-15,17-18,28-29,36H,9-12,16,19H2,1-2H3,(H,33,37) QJYUYUHUFSWUBK-UHFFFAOYSA-N 96673 3-[(Z)-2-fluoro-2-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethenyl]-N-[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-4-methylbenzamide::US12509424, Example 200 Platelet-derived growth factor subunit B Homo sapiens 16.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96673 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96673&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2975130 164037917 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130289 Cc1ccc(C(=O)NCC(O)C(C)(C)C)cc1/C=C(\F)c1cncc(CN2CCN(C)CC2)c1 InChI=1S/C27H37FN4O2/c1-19-6-7-21(26(34)30-17-25(33)27(2,3)4)13-22(19)14-24(28)23-12-20(15-29-16-23)18-32-10-8-31(5)9-11-32/h6-7,12-16,25,33H,8-11,17-18H2,1-5H3,(H,30,34) LFJLHBHGMXJTNF-UHFFFAOYSA-N 96674 3-[(Z)-2-fluoro-2-{5-[(4-methylpiperazin-1-yl)methyl]pyridin-3-yl}ethenyl]-N-(2-hydroxy-3,3-dimethylbutyl)-4-methylbenzamide::US12509424, Example 201 Platelet-derived growth factor subunit B Homo sapiens 38.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96674 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96674&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2251040 164037918 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130290 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(/C=C(\F)c2cnc(NCC3CC3)nc2)c1 InChI=1S/C23H26F2N4O2/c24-18-8-7-15(22(31)29-20-3-1-2-4-21(20)30)9-16(18)10-19(25)17-12-27-23(28-13-17)26-11-14-5-6-14/h7-10,12-14,20-21,30H,1-6,11H2,(H,29,31)(H,26,27,28) JJGMPXBYLPQZHY-UHFFFAOYSA-N 96675 3-[(Z)-2-{2-[(cyclopropylmethyl)amino]pyrimidin-5-yl}-2-fluoroethenyl]-4-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 202 Platelet-derived growth factor subunit B Homo sapiens 77.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96675 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96675&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 971456 164037919 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130291 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(/C=C(\F)c2cnc(NC3CC3)nc2)c1 InChI=1S/C22H24F2N4O2/c23-17-8-5-13(21(30)28-19-3-1-2-4-20(19)29)9-14(17)10-18(24)15-11-25-22(26-12-15)27-16-6-7-16/h5,8-12,16,19-20,29H,1-4,6-7H2,(H,28,30)(H,25,26,27) FKEOHBOFXBVSTH-UHFFFAOYSA-N 96676 3-{(Z)-2-[2-(cyclopropylamino)pyrimidin-5-yl]-2-fluoroethenyl}-4-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 203 Platelet-derived growth factor subunit B Homo sapiens 61.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96676 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96676&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 830161 164037920 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130292 Cc1nc(N)ncc1/C(F)=C/c1cc(C(=O)N[C@H]2CCCC[C@@H]2O)ccc1F InChI=1S/C20H22F2N4O2/c1-11-14(10-24-20(23)25-11)16(22)9-13-8-12(6-7-15(13)21)19(28)26-17-4-2-3-5-18(17)27/h6-10,17-18,27H,2-5H2,1H3,(H,26,28)(H2,23,24,25) WMZWOJHNTVQPMB-UHFFFAOYSA-N 96677 3-[(Z)-2-(2-amino-4-methylpyrimidin-5-yl)-2-fluoroethenyl]-4-fluoro-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 204 Platelet-derived growth factor subunit B Homo sapiens 21.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96677 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96677&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 3152402 164037921 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130293 CNc1ncc(/C(F)=C/c2cc(C(=O)N[C@H]3CCCC[C@@H]3O)ccc2F)cn1 InChI=1S/C20H22F2N4O2/c1-23-20-24-10-14(11-25-20)16(22)9-13-8-12(6-7-15(13)21)19(28)26-17-4-2-3-5-18(17)27/h6-11,17-18,27H,2-5H2,1H3,(H,26,28)(H,23,24,25) BVMYGZHRSBIITC-UHFFFAOYSA-N 96678 4-fluoro-3-{(Z)-2-fluoro-2-[2-(methylamino)pyrimidin-5-yl]ethenyl}-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 205 Platelet-derived growth factor subunit B Homo sapiens 130 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96678 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96678&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2169847 164037922 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130294 Cc1ccc(C(=O)N[C@H]2CCCC[C@@H]2O)cc1/C=C(\F)c1cnc(N)cn1 InChI=1S/C20H23FN4O2/c1-12-6-7-13(20(27)25-16-4-2-3-5-18(16)26)8-14(12)9-15(21)17-10-24-19(22)11-23-17/h6-11,16,18,26H,2-5H2,1H3,(H2,22,24)(H,25,27) FSLRMEDVKBOYQC-UHFFFAOYSA-N 96679 3-[(Z)-2-(5-aminopyrazin-2-yl)-2-fluoroethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]-4-methylbenzamide::US12509424, Example 206 Platelet-derived growth factor subunit B Homo sapiens 31.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96679 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96679&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 2167075 164037923 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23 130295 O=C(N[C@H]1CCCC[C@@H]1O)c1ccc(F)c(/C=C(\F)c2cncc(F)c2)c1 InChI=1S/C20H19F3N2O2/c21-15-8-14(10-24-11-15)17(23)9-13-7-12(5-6-16(13)22)20(27)25-18-3-1-2-4-19(18)26/h5-11,18-19,26H,1-4H2,(H,25,27) HYCKADUFYHGCKH-UHFFFAOYSA-N 96680 4-fluoro-3-[(Z)-2-fluoro-2-(5-fluoropyridin-3-yl)ethenyl]-N-[(1S,2S)-2-hydroxycyclohexyl]benzamide::US12509424, Example 207 Platelet-derived growth factor subunit B Homo sapiens 100.0 US Patent 10.7270/Q2KD23QF US12509424 Asada, J; Haruta, Y; Yakushiji, H; Tanaka, T; Kuramoto, K; Kosugi, K; Fuchikami, C 12/30/2025 5/11/2026 Nippon Shinyaku Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96680 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=10091&target=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96680&enzyme=Platelet-derived+growth+factor+subunit+B&column=ki&startPg=0&Increment=50&submit=Search 16190455 164037924 1 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA 3MJG,4QCI,6T9E,4HQU,1PDG,4HQX Platelet-derived growth factor subunit B PDGFB_HUMAN P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23