BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
130296	Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H24N6O3S/c1-16-6-8-19(27-24(31)18-4-3-5-21(13-18)34(2,32)33)12-17(16)7-9-20-14-22(30-29-20)28-23-15-25-10-11-26-23/h3-6,8,10-15H,7,9H2,1-2H3,(H,27,31)(H2,26,28,29,30)	JZKIVYDSXGDJOM-UHFFFAOYSA-N	96681	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(methylsulfonyl)benzamide::US12509446, Compound 1	Tyrosine-protein kinase Fyn	Homo sapiens		 36.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96681&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			16191234	164037925							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130297	Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C26H26N8O/c1-17-4-6-20(31-25(35)19-8-9-29-22(13-19)26(2,3)16-27)12-18(17)5-7-21-14-23(34-33-21)32-24-15-28-10-11-30-24/h4,6,8-15H,5,7H2,1-3H3,(H,31,35)(H2,30,32,33,34)	ULDPBEDPVNUHIM-UHFFFAOYSA-N	96682	2-(2-cyanopropan-2-yl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)isonicotinamide::US12509446, Compound 2	Tyrosine-protein kinase Fyn	Homo sapiens		 10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96682&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			16191684	164037926							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130298	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H21F3N6O/c1-15-5-7-19(30-23(34)17-3-2-4-18(11-17)24(25,26)27)12-16(15)6-8-20-13-21(33-32-20)31-22-14-28-9-10-29-22/h2-5,7,9-14H,6,8H2,1H3,(H,30,34)(H2,29,31,32,33)	ULHMIFGFUPWWCR-UHFFFAOYSA-N	96683	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 3	Tyrosine-protein kinase Fyn	Homo sapiens		 9.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96683&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			3112062	164037927							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130299	CCNC1(c2ccc(C(=O)Nc3ccc(C)c(CCc4cc(Nc5cnccn5)[nH]n4)c3)cc2)CC1	InChI=1S/C28H31N7O/c1-3-31-28(12-13-28)22-8-5-20(6-9-22)27(36)32-23-10-4-19(2)21(16-23)7-11-24-17-25(35-34-24)33-26-18-29-14-15-30-26/h4-6,8-10,14-18,31H,3,7,11-13H2,1-2H3,(H,32,36)(H2,30,33,34,35)	GRFUBQVMULOMFY-UHFFFAOYSA-N	96684	4-(1-(ethylamino)cyclopropyl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)benzamide::US12509446, Compound 4	Tyrosine-protein kinase Fyn	Homo sapiens		 21.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96684&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			2929978	164037928							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130300	Cc1ccc(NC(=O)c2ccnc(C(C)(C)O)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C25H27N7O2/c1-16-4-6-19(29-24(33)18-8-9-27-21(13-18)25(2,3)34)12-17(16)5-7-20-14-22(32-31-20)30-23-15-26-10-11-28-23/h4,6,8-15,34H,5,7H2,1-3H3,(H,29,33)(H2,28,30,31,32)	YDNHAHAXIKZEOE-UHFFFAOYSA-N	96685	2-(2-hydroxypropan-2-yl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)isonicotinamide::US12509446, Compound 5	Tyrosine-protein kinase Fyn	Homo sapiens		 6.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96685&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			1570021	164037929							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130301	Cc1nc(C(=O)Nc2ccc(C)c(CCc3cc(Nc4cnccn4)[nH]n3)c2)c(C(F)(F)F)o1	InChI=1S/C22H20F3N7O2/c1-12-3-5-15(29-21(33)19-20(22(23,24)25)34-13(2)28-19)9-14(12)4-6-16-10-17(32-31-16)30-18-11-26-7-8-27-18/h3,5,7-11H,4,6H2,1-2H3,(H,29,33)(H2,27,30,31,32)	OJCGTZDKMQRGBU-UHFFFAOYSA-N	96686	2-methyl-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-5-(trifluoromethyl)oxazole-4-carboxamide::US12509446, Compound 6	Tyrosine-protein kinase Fyn	Homo sapiens		 112							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96686&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			746603	164037930							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130302	Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccc2F)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H20F4N6O/c1-14-2-5-17(31-23(35)19-11-16(24(26,27)28)4-7-20(19)25)10-15(14)3-6-18-12-21(34-33-18)32-22-13-29-8-9-30-22/h2,4-5,7-13H,3,6H2,1H3,(H,31,35)(H2,30,32,33,34)	UOMBLHAGLMPPDO-UHFFFAOYSA-N	96687	2-fluoro-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-5-(trifluoromethyl)benzamide::US12509446, Compound 7	Tyrosine-protein kinase Fyn	Homo sapiens		 63.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96687&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			22276	164037931							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130303	Cc1ccc(NC(=O)c2cc(S(=O)(=O)C3CC3)ccn2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C25H25N7O3S/c1-16-2-4-18(29-25(33)22-14-21(8-9-27-22)36(34,35)20-6-7-20)12-17(16)3-5-19-13-23(32-31-19)30-24-15-26-10-11-28-24/h2,4,8-15,20H,3,5-7H2,1H3,(H,29,33)(H2,28,30,31,32)	HTTQPYUEKMMVKV-UHFFFAOYSA-N	96688	4-(cyclopropylsulfonyl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)picolinamide::US12509446, Compound 8	Tyrosine-protein kinase Fyn	Homo sapiens		 20.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96688&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			1497794	164037932							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130304	CC(C)Cc1ccc(C(=O)Nc2ccc(F)c(CCc3cc(NC(=O)c4ncccn4)[nH]n3)c2)cn1	InChI=1S/C26H26FN7O2/c1-16(2)12-19-6-5-18(15-30-19)25(35)31-20-8-9-22(27)17(13-20)4-7-21-14-23(34-33-21)32-26(36)24-28-10-3-11-29-24/h3,5-6,8-11,13-16H,4,7,12H2,1-2H3,(H,31,35)(H2,32,33,34,36)	HNMJHYJMWUTAOI-UHFFFAOYSA-N	96689	N-(3-(2-fluoro-5-(6-isobutylnicotinamido)phenethyl)-1H-pyrazol-5-yl)pyrimidine-2-carboxamide::US12509446, Compound 9	Tyrosine-protein kinase Fyn	Homo sapiens		 16.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96689&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			6870484	164037933							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130305	O=C(Nc1ccc(F)c(CCc2cc(Nc3cc4c(cn3)CN(CCO)C4)[nH]n2)c1)c1cccc(C(F)(F)F)c1	InChI=1S/C28H26F4N6O2/c29-24-7-6-22(34-27(40)18-2-1-3-21(10-18)28(30,31)32)11-17(24)4-5-23-13-26(37-36-23)35-25-12-19-15-38(8-9-39)16-20(19)14-33-25/h1-3,6-7,10-14,39H,4-5,8-9,15-16H2,(H,34,40)(H2,33,35,36,37)	KWJWEAZZJUJTME-UHFFFAOYSA-N	96690	N-(4-fluoro-3-(2-(5-((2-(2-hydroxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 10	Tyrosine-protein kinase Fyn	Homo sapiens		 4.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96690&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			16193924	164037934							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130306	CC(C)(C#N)c1cc(C(=O)Nc2ccc(F)c(CCc3cc(Nc4cnccn4)[nH]n3)c2)ccn1	InChI=1S/C25H23FN8O/c1-25(2,15-27)21-12-17(7-8-29-21)24(35)31-18-5-6-20(26)16(11-18)3-4-19-13-22(34-33-19)32-23-14-28-9-10-30-23/h5-14H,3-4H2,1-2H3,(H,31,35)(H2,30,32,33,34)	XGLTXWNPJZJPHN-UHFFFAOYSA-N	96692	2-(2-cyanopropan-2-yl)-N-(4-fluoro-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)isonicotinamide::US12509446, Compound 11	Tyrosine-protein kinase Fyn	Homo sapiens		 21.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96692&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			718460	164037936							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130307	CS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(CCc3cc(Nc4cnccn4)[nH]n3)c2)c1	InChI=1S/C23H21FN6O3S/c1-34(32,33)19-4-2-3-16(12-19)23(31)27-17-7-8-20(24)15(11-17)5-6-18-13-21(30-29-18)28-22-14-25-9-10-26-22/h2-4,7-14H,5-6H2,1H3,(H,27,31)(H2,26,28,29,30)	FYNJKZQYZXMOIR-UHFFFAOYSA-N	96693	N-(4-fluoro-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(methylsulfonyl)benzamide::US12509446, Compound 12	Tyrosine-protein kinase Fyn	Homo sapiens		 24.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96693&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			5890451	164037937							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130308	O=C(Nc1ccc(F)c(CCc2cc(Nc3cnccn3)[nH]n2)c1)c1cccc(C(F)(F)F)c1	InChI=1S/C23H18F4N6O/c24-19-7-6-17(30-22(34)15-2-1-3-16(10-15)23(25,26)27)11-14(19)4-5-18-12-20(33-32-18)31-21-13-28-8-9-29-21/h1-3,6-13H,4-5H2,(H,30,34)(H2,29,31,32,33)	OYWWVXPPTOSQMX-UHFFFAOYSA-N	96694	N-(4-fluoro-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl) benzamide::US12509446, Compound 13	Tyrosine-protein kinase Fyn	Homo sapiens		 26.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96694&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			16194546	164037938							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130309	Cc1cnc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)c(C)n1	InChI=1S/C25H22F4N6O/c1-14-13-30-23(15(2)31-14)33-22-12-20(34-35-22)7-6-16-11-19(8-9-21(16)26)32-24(36)17-4-3-5-18(10-17)25(27,28)29/h3-5,8-13H,6-7H2,1-2H3,(H,32,36)(H2,30,33,34,35)	BKJGGCGVBGNJTJ-UHFFFAOYSA-N	96695	N-(3-(2-(5-((3,5-dimethylpyrazin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 14	Tyrosine-protein kinase Fyn	Homo sapiens		 31.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96695&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			4416228	164037939							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130310	Cc1nccnc1Nc1cc(CCc2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2F)n[nH]1	InChI=1S/C24H20F4N6O/c1-14-22(30-10-9-29-14)32-21-13-19(33-34-21)6-5-15-12-18(7-8-20(15)25)31-23(35)16-3-2-4-17(11-16)24(26,27)28/h2-4,7-13H,5-6H2,1H3,(H,31,35)(H2,30,32,33,34)	QDOAHOIDZPGOTI-UHFFFAOYSA-N	96696	N-(4-fluoro-3-(2-(5-((3-methylpyrazin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 15	Tyrosine-protein kinase Fyn	Homo sapiens		 18.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96696&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			3960357	164037940							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130311	O=C(Nc1ccc(Cl)c(CCc2cc(Nc3cnccn3)[nH]n2)c1)c1cccc(C(F)(F)F)c1	InChI=1S/C23H18ClF3N6O/c24-19-7-6-17(30-22(34)15-2-1-3-16(10-15)23(25,26)27)11-14(19)4-5-18-12-20(33-32-18)31-21-13-28-8-9-29-21/h1-3,6-13H,4-5H2,(H,30,34)(H2,29,31,32,33)	HIWHDJFEPJAOJT-UHFFFAOYSA-N	96697	N-(4-chloro-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 16	Tyrosine-protein kinase Fyn	Homo sapiens		 24.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96697&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			2153989	164037941							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130312	CCN1Cc2cnc(Nc3cc(CCc4cc(NC(=O)c5cccc(C(F)(F)F)c5)ccc4C)n[nH]3)cc2C1	InChI=1S/C29H29F3N6O/c1-3-38-16-21-13-26(33-15-22(21)17-38)35-27-14-25(36-37-27)10-8-19-12-24(9-7-18(19)2)34-28(39)20-5-4-6-23(11-20)29(30,31)32/h4-7,9,11-15H,3,8,10,16-17H2,1-2H3,(H,34,39)(H2,33,35,36,37)	HQKHHGPVMMIKFH-UHFFFAOYSA-N	96698	N-(3-(2-(5-((2-ethyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-methylphenyl) -3-(trifluoromethyl)benzamide::US12509446, Compound 17	Tyrosine-protein kinase Fyn	Homo sapiens		 8.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96698&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			5716919	164037942							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130313	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(NC(=O)c2ccccn2)[nH]n1	InChI=1S/C26H22F3N5O2/c1-16-8-10-20(31-24(35)18-5-4-6-19(13-18)26(27,28)29)14-17(16)9-11-21-15-23(34-33-21)32-25(36)22-7-2-3-12-30-22/h2-8,10,12-15H,9,11H2,1H3,(H,31,35)(H2,32,33,34,36)	VDSROHNDKMIJSJ-UHFFFAOYSA-N	96699	N-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenethyl)-1H-pyrazol-3-yl)picolinamide::US12509446, Compound 18	Tyrosine-protein kinase Fyn	Homo sapiens		 15.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96699&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			91899613	164037943							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130314	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(NC(=O)c2ccc(F)cc2)[nH]n1	InChI=1S/C27H22F4N4O2/c1-16-5-11-22(32-26(37)19-3-2-4-20(13-19)27(29,30)31)14-18(16)8-12-23-15-24(35-34-23)33-25(36)17-6-9-21(28)10-7-17/h2-7,9-11,13-15H,8,12H2,1H3,(H,32,37)(H2,33,34,35,36)	YCXFQTHSQSTPOU-UHFFFAOYSA-N	96700	N-(3-(2-(3-(4-fluorobenzamido)-1H-pyrazol-5-yl)ethyl)-4-methylphenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 19	Tyrosine-protein kinase Fyn	Homo sapiens		 69.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96700&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			3787753	164037944							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130315	Cc1ccc(NC(=O)N2CCC3(CCC3)C2)cc1CCc1cc(Nc2nccnc2C)[nH]n1	InChI=1S/C25H31N7O/c1-17-4-6-20(28-24(33)32-13-10-25(16-32)8-3-9-25)14-19(17)5-7-21-15-22(31-30-21)29-23-18(2)26-11-12-27-23/h4,6,11-12,14-15H,3,5,7-10,13,16H2,1-2H3,(H,28,33)(H2,27,29,30,31)	HSUDNYYMMLOKIX-UHFFFAOYSA-N	96701	N-(4-methyl-3-(2-(5-((3-methylpyrazin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-6-azaspiro[3.4]octane-6-carboxamide::US12509446, Compound 20	Tyrosine-protein kinase Fyn	Homo sapiens		 18.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96701	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96701&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			3370345	164037945							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130316	CCC1(CC)CCN(C(=O)Nc2ccc(C)c(CCc3cc(Nc4nccnc4C)[nH]n3)c2)C1	InChI=1S/C26H35N7O/c1-5-26(6-2)11-14-33(17-26)25(34)29-21-9-7-18(3)20(15-21)8-10-22-16-23(32-31-22)30-24-19(4)27-12-13-28-24/h7,9,12-13,15-16H,5-6,8,10-11,14,17H2,1-4H3,(H,29,34)(H2,28,30,31,32)	HZOYYEZOVXMBEV-UHFFFAOYSA-N	96702	3,3-diethyl-N-(4-methyl-3-(2-(5-((3-methylpyrazin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)pyrrolidine-1-carboxamide::US12509446, Compound 21	Tyrosine-protein kinase Fyn	Homo sapiens		 5.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96702	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96702&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			2095232	164037946							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130317	CCC1(CC)CCN(C(=O)Nc2ccc(C)c(CCc3cc(Nc4cnccn4)[nH]n3)c2)C1	InChI=1S/C25H33N7O/c1-4-25(5-2)10-13-32(17-25)24(33)28-20-8-6-18(3)19(14-20)7-9-21-15-22(31-30-21)29-23-16-26-11-12-27-23/h6,8,11-12,14-16H,4-5,7,9-10,13,17H2,1-3H3,(H,28,33)(H2,27,29,30,31)	NQZOLXFCEWNYGL-UHFFFAOYSA-N	96703	3,3-diethyl-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)pyrrolidine-1-carboxamide::US12509446, Compound 22	Tyrosine-protein kinase Fyn	Homo sapiens		 7.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96703	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96703&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			91899614	164037947							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130318	Cc1ccc(NC(=O)NC2CCC(C)(C)CC2)cc1CCc1cc(NC(=O)c2ccc(OC3CN(C(C)C)C3)cc2)[nH]n1	InChI=1S/C34H46N6O3/c1-22(2)40-20-30(21-40)43-29-12-8-24(9-13-29)32(41)37-31-19-28(38-39-31)11-7-25-18-27(10-6-23(25)3)36-33(42)35-26-14-16-34(4,5)17-15-26/h6,8-10,12-13,18-19,22,26,30H,7,11,14-17,20-21H2,1-5H3,(H2,35,36,42)(H2,37,38,39,41)	GBFNLUOGEVJKIW-UHFFFAOYSA-N	96704	N-(3-(5-(3-(4,4-dimethylcyclohexyl)ureido)-2-methylphenethyl)-1H-pyrazol-5-yl)-4-((1-isopropylazetidin-3-yl)oxy)benzamide::US12509446, Compound 23	Tyrosine-protein kinase Fyn	Homo sapiens		 5.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96704	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96704&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			3450662	164037948							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130319	Cc1ccc(NC(=O)NC2CCCC2)cc1CCc1cc(NC(=O)c2ccc(N3CCN(C)CC3)cc2)[nH]n1	InChI=1S/C30H39N7O2/c1-21-7-11-25(32-30(39)31-24-5-3-4-6-24)19-23(21)8-12-26-20-28(35-34-26)33-29(38)22-9-13-27(14-10-22)37-17-15-36(2)16-18-37/h7,9-11,13-14,19-20,24H,3-6,8,12,15-18H2,1-2H3,(H2,31,32,39)(H2,33,34,35,38)	IPZOQUOQSYNGIE-UHFFFAOYSA-N	96705	N-(3-(5-(3-cyclopentylureido)-2-methylphenethyl)-1H-pyrazol-5-yl)-4-(4-methylpiperazin-1-yl)benzamide::US12509446, Compound 24	Tyrosine-protein kinase Fyn	Homo sapiens		 2.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96705	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96705&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			2305793	164037949							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130320	Cc1ccc(NC(=O)NC2CCC(C)(C)CC2)cc1CCc1cc(NC(=O)c2ccc(N3CCN(C)CC3)cc2)[nH]n1	InChI=1S/C33H45N7O2/c1-23-5-9-27(35-32(42)34-26-13-15-33(2,3)16-14-26)21-25(23)6-10-28-22-30(38-37-28)36-31(41)24-7-11-29(12-8-24)40-19-17-39(4)18-20-40/h5,7-9,11-12,21-22,26H,6,10,13-20H2,1-4H3,(H2,34,35,42)(H2,36,37,38,41)	MTNLRGVARHYTAD-UHFFFAOYSA-N	96706	N-(3-(5-(3-(4,4-dimethylcyclohexyl)ureido)-2-methylphenethyl)-1H-pyrazol-5-yl)-4-(1-methylpiperidin-4-yl)benzamide::US12509446, Compound 25	Tyrosine-protein kinase Fyn	Homo sapiens		 3.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96706	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96706&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			4591140	164037950							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130321	Cc1nc(CN2CCOCC2)cc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)[nH]n2)n1	InChI=1S/C29H29F4N7O2/c1-18-34-24(17-40-9-11-42-12-10-40)16-26(35-18)37-27-15-23(38-39-27)6-5-19-14-22(7-8-25(19)30)36-28(41)20-3-2-4-21(13-20)29(31,32)33/h2-4,7-8,13-16H,5-6,9-12,17H2,1H3,(H,36,41)(H2,34,35,37,38,39)	HYLAYVUXJLXEMK-UHFFFAOYSA-N	96707	N-(4-fluoro-3-(2-(3-((2-methyl-6-(morpholinomethyl)pyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 26	Tyrosine-protein kinase Fyn	Homo sapiens		 12.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96707&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			4879418	164037951							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130322	Cc1nc(CN2C[C@@H](C)O[C@@H](C)C2)cc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)[nH]n2)n1	InChI=1S/C31H33F4N7O2/c1-18-15-42(16-19(2)44-18)17-26-14-28(37-20(3)36-26)39-29-13-25(40-41-29)8-7-21-12-24(9-10-27(21)32)38-30(43)22-5-4-6-23(11-22)31(33,34)35/h4-6,9-14,18-19H,7-8,15-17H2,1-3H3,(H,38,43)(H2,36,37,39,40,41)	LJPJINRCHKNFIT-UHFFFAOYSA-N	96709	N-(3-(2-(3-((6-(((2S,6R)-2,6-dimethylmorpholino)methyl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 27	Tyrosine-protein kinase Fyn	Homo sapiens		 10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96709&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			5385994	164037953							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130323	Cc1nc(CN2CCCC2)cc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)[nH]n2)n1	InChI=1S/C29H29F4N7O/c1-18-34-24(17-40-11-2-3-12-40)16-26(35-18)37-27-15-23(38-39-27)8-7-19-14-22(9-10-25(19)30)36-28(41)20-5-4-6-21(13-20)29(31,32)33/h4-6,9-10,13-16H,2-3,7-8,11-12,17H2,1H3,(H,36,41)(H2,34,35,37,38,39)	MTADWLQFOMKPHV-UHFFFAOYSA-N	96710	N-(4-fluoro-3-(2-(3-((2-methyl-6-(pyrrolidin-1-ylmethyl)pyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 28	Tyrosine-protein kinase Fyn	Homo sapiens		 17.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96710&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			3856622	164037954							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130324	CCN1CCN(c2cc(Nc3cc(CCc4cc(NC(=O)c5cccc(C(F)(F)F)c5)ccc4F)n[nH]3)nc(C)n2)CC1	InChI=1S/C30H32F4N8O/c1-3-41-11-13-42(14-12-41)28-18-26(35-19(2)36-28)38-27-17-24(39-40-27)8-7-20-16-23(9-10-25(20)31)37-29(43)21-5-4-6-22(15-21)30(32,33)34/h4-6,9-10,15-18H,3,7-8,11-14H2,1-2H3,(H,37,43)(H2,35,36,38,39,40)	SIXIPLANITULIR-UHFFFAOYSA-N	96711	N-(3-(2-(3-((6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 29	Tyrosine-protein kinase Fyn	Homo sapiens		 15.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96711&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			751683	164037955							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130325	Cc1nc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)cc(N2CCN(CCO)CC2)n1	InChI=1S/C30H32F4N8O2/c1-19-35-26(18-28(36-19)42-11-9-41(10-12-42)13-14-43)38-27-17-24(39-40-27)6-5-20-16-23(7-8-25(20)31)37-29(44)21-3-2-4-22(15-21)30(32,33)34/h2-4,7-8,15-18,43H,5-6,9-14H2,1H3,(H,37,44)(H2,35,36,38,39,40)	DNKNEOHEQUZRGL-UHFFFAOYSA-N	96712	N-(4-fluoro-3-(2-(3-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl) benzamide::US12509446, Compound 30	Tyrosine-protein kinase Fyn	Homo sapiens		 6.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96712&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			16681852	164037956							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130326	Cc1nc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)cc(N2CC(O)C2)n1	InChI=1S/C27H25F4N7O2/c1-15-32-23(12-25(33-15)38-13-21(39)14-38)35-24-11-20(36-37-24)6-5-16-10-19(7-8-22(16)28)34-26(40)17-3-2-4-18(9-17)27(29,30)31/h2-4,7-12,21,39H,5-6,13-14H2,1H3,(H,34,40)(H2,32,33,35,36,37)	CSYKYDZYAZHBBD-UHFFFAOYSA-N	96713	N-(4-fluoro-3-(2-(3-((6-(3-hydroxyazetidin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 31	Tyrosine-protein kinase Fyn	Homo sapiens		 10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96713&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			6868679	164037957							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130327	Cc1nc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)cc(N2CC[C@H](N(C)C)C2)n1	InChI=1S/C30H32F4N8O/c1-18-35-26(16-28(36-18)42-12-11-24(17-42)41(2)3)38-27-15-23(39-40-27)8-7-19-14-22(9-10-25(19)31)37-29(43)20-5-4-6-21(13-20)30(32,33)34/h4-6,9-10,13-16,24H,7-8,11-12,17H2,1-3H3,(H,37,43)(H2,35,36,38,39,40)	BEPKLJSGBABDRT-UHFFFAOYSA-N	96714	(S)-N-(3-(2-(3-((6-(3-(dimethylamino)pyrrolidin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 32	Tyrosine-protein kinase Fyn	Homo sapiens		 9.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96714&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			5452969	164037958							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130328	Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H22F2N6O/c1-15-5-7-19(29-24(33)18-4-2-3-17(11-18)23(25)26)12-16(15)6-8-20-13-21(32-31-20)30-22-14-27-9-10-28-22/h2-5,7,9-14,23H,6,8H2,1H3,(H,29,33)(H2,28,30,31,32)	RZZDYHJFXFRDOA-UHFFFAOYSA-N	96715	3-(difluoromethyl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl) benzamide::US12509446, Compound 33	Tyrosine-protein kinase Fyn	Homo sapiens		 16.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96715&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			6858937	164037959							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130329	CC(=O)N1Cc2cnc(Nc3cc(CCc4cc(NC(=O)c5cccc(C(F)F)c5)ccc4C)n[nH]3)cc2C1	InChI=1S/C29H28F2N6O2/c1-17-6-8-24(33-29(39)21-5-3-4-20(10-21)28(30)31)11-19(17)7-9-25-13-27(36-35-25)34-26-12-22-15-37(18(2)38)16-23(22)14-32-26/h3-6,8,10-14,28H,7,9,15-16H2,1-2H3,(H,33,39)(H2,32,34,35,36)	NCQNADCXUGRURC-UHFFFAOYSA-N	96716	N-(3-(2-(5-((2-acetyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-methylphenyl)-3-(trifluoromethyl) benzamide::US12509446, Compound 34	Tyrosine-protein kinase Fyn	Homo sapiens		 6.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96716&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			91899615	164037960							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130330	Cc1ccc(NC(=O)c2cccc(S(=O)(=O)C(C)C)c2)cc1CCc1cc(Nc2ncccc2C)[nH]n1	InChI=1S/C28H31N5O3S/c1-18(2)37(35,36)25-9-5-8-22(16-25)28(34)30-23-12-10-19(3)21(15-23)11-13-24-17-26(33-32-24)31-27-20(4)7-6-14-29-27/h5-10,12,14-18H,11,13H2,1-4H3,(H,30,34)(H2,29,31,32,33)	ZGIULFTYFSFGOA-UHFFFAOYSA-N	96717	3-(isopropylsulfonyl)-N-(4-methyl-3-(2-(5-((3-methylpyridin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl) benzamide::US12509446, Compound 35	Tyrosine-protein kinase Fyn	Homo sapiens		 88.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96717&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			5517140	164037961							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130331	Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1CCc1cc(Nc2ncccc2C)[nH]n1	InChI=1S/C28H29N7O/c1-18-7-9-22(32-27(36)21-11-13-30-24(15-21)28(3,4)17-29)14-20(18)8-10-23-16-25(35-34-23)33-26-19(2)6-5-12-31-26/h5-7,9,11-16H,8,10H2,1-4H3,(H,32,36)(H2,31,33,34,35)	WLLGIRVDLYIHFD-UHFFFAOYSA-N	96718	2-(2-cyanopropan-2-yl)-N-(4-methyl-3-(2-(5-((3-methylpyridin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)isonicotinamide::US12509446, Compound 36	Tyrosine-protein kinase Fyn	Homo sapiens		 32.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96718&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			751678	164037962							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130332	Cc1nc(C#N)cc(Nc2cc(CCc3cc(NC(=O)c4cccc(S(=O)(=O)N(C)C)c4)ccc3C)n[nH]2)n1	InChI=1S/C27H28N8O3S/c1-17-8-10-21(31-27(36)20-6-5-7-24(13-20)39(37,38)35(3)4)12-19(17)9-11-22-14-26(34-33-22)32-25-15-23(16-28)29-18(2)30-25/h5-8,10,12-15H,9,11H2,1-4H3,(H,31,36)(H2,29,30,32,33,34)	SDHXJWIEOAKZCF-UHFFFAOYSA-N	96719	N-(3-(2-(5-((6-cyano-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-methylphenyl)-3-(N,N-dimethylsulfamoyl)benzamide::US12509446, Compound 37	Tyrosine-protein kinase Fyn	Homo sapiens		 24.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96719&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			6869784	164037963							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130333	Cc1nc(C#N)cc(Nc2cc(CCc3cc(NC(=O)N4CCC5(CCCC5)CC4)ccc3C)n[nH]2)n1	InChI=1S/C28H34N8O/c1-19-5-7-22(32-27(37)36-13-11-28(12-14-36)9-3-4-10-28)15-21(19)6-8-23-16-26(35-34-23)33-25-17-24(18-29)30-20(2)31-25/h5,7,15-17H,3-4,6,8-14H2,1-2H3,(H,32,37)(H2,30,31,33,34,35)	AQWQQJIMTOWWGH-UHFFFAOYSA-N	96720	N-(3-(2-(5-((6-cyano-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-methylphenyl)-8-azaspiro [4.5] decane-8-carboxamide::US12509446, Compound 38	Tyrosine-protein kinase Fyn	Homo sapiens		 2.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96720	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96720&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			950930	164037964							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130334	Cc1nc(C#N)cc(Nc2cc(CCc3cc(NC(=O)c4ccc(CN(C)C)c(C(F)(F)F)c4)ccc3F)n[nH]2)n1	InChI=1S/C28H26F4N8O/c1-16-34-22(14-33)13-25(35-16)37-26-12-21(38-39-26)7-6-17-10-20(8-9-24(17)29)36-27(41)18-4-5-19(15-40(2)3)23(11-18)28(30,31)32/h4-5,8-13H,6-7,15H2,1-3H3,(H,36,41)(H2,34,35,37,38,39)	QAGDHLTUULNQQP-UHFFFAOYSA-N	96721	N-(3-(2-(5-((6-cyano-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-fluorophenyl)-4-((dimethylamino) methyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 39	Tyrosine-protein kinase Fyn	Homo sapiens		 1.000							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96721&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			751676	164037965							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130335	Cc1ncc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)cn1	InChI=1S/C24H20F4N6O/c1-14-29-12-20(13-30-14)31-22-11-19(33-34-22)6-5-15-10-18(7-8-21(15)25)32-23(35)16-3-2-4-17(9-16)24(26,27)28/h2-4,7-13H,5-6H2,1H3,(H,32,35)(H2,31,33,34)	ZVYQPQAIHVRYCF-UHFFFAOYSA-N	96722	N-(4-fluoro-3-(2-(5-((2-methylpyrimidin-5-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoro methyl)benzamide::US12509446, Compound 40	Tyrosine-protein kinase Fyn	Homo sapiens		 99.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96722&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			751698	164037966							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130336	Cc1ccc(NC(=O)c2cc(C(C)(C)C#N)ccn2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C26H26N8O/c1-17-4-6-20(31-25(35)22-13-19(8-9-29-22)26(2,3)16-27)12-18(17)5-7-21-14-23(34-33-21)32-24-15-28-10-11-30-24/h4,6,8-15H,5,7H2,1-3H3,(H,31,35)(H2,30,32,33,34)	VAWMENKWNNMTSN-UHFFFAOYSA-N	96723	4-(2-cyanopropan-2-yl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)picolinamide::US12509446, Compound 41	Tyrosine-protein kinase Fyn	Homo sapiens		 8.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96723&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			5357791	164037967							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130337	Cc1nc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)[nH]n2)cc(C2C=NN(CCO)C2)n1	InChI=1S/C29H28F4N8O2/c1-17-35-25(20-15-34-41(16-20)9-10-42)14-26(36-17)38-27-13-23(39-40-27)6-5-18-12-22(7-8-24(18)30)37-28(43)19-3-2-4-21(11-19)29(31,32)33/h2-4,7-8,11-15,20,42H,5-6,9-10,16H2,1H3,(H,37,43)(H2,35,36,38,39,40)	FAKWGXAMVZSCFX-UHFFFAOYSA-N	96724	N-(4-fluoro-3-(2-(3-((6-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)-2-methylpyrimidin-4-yl) amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 42	Tyrosine-protein kinase Fyn	Homo sapiens		 13.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96724&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			344197	164037968							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130338	Cc1nc(Nc2cc(CCc3ccc(F)c(NC(=O)c4cccc(C(F)(F)F)c4)c3)n[nH]2)cc(N2CCOCC2)n1	InChI=1S/C28H27F4N7O2/c1-17-33-24(16-26(34-17)39-9-11-41-12-10-39)36-25-15-21(37-38-25)7-5-18-6-8-22(29)23(13-18)35-27(40)19-3-2-4-20(14-19)28(30,31)32/h2-4,6,8,13-16H,5,7,9-12H2,1H3,(H,35,40)(H2,33,34,36,37,38)	YAIMXASJMPAVJA-UHFFFAOYSA-N	96726	N-(2-fluoro-5-(2-(5-((2-methyl-6-morpholinopyrimidin-4-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 43	Tyrosine-protein kinase Fyn	Homo sapiens		 19.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96726&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			241200	164037970							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130339	Cc1nc(Nc2cc(CCc3ccc(F)c(NC(=O)c4cccc(C(F)(F)F)c4)c3)n[nH]2)cc(N2CCN(CCO)CC2)n1	InChI=1S/C30H32F4N8O2/c1-19-35-26(18-28(36-19)42-11-9-41(10-12-42)13-14-43)38-27-17-23(39-40-27)7-5-20-6-8-24(31)25(15-20)37-29(44)21-3-2-4-22(16-21)30(32,33)34/h2-4,6,8,15-18,43H,5,7,9-14H2,1H3,(H,37,44)(H2,35,36,38,39,40)	MAESUCGGNZJRTC-UHFFFAOYSA-N	96727	N-(2-fluoro-5-(2-(3-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl) ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 44	Tyrosine-protein kinase Fyn	Homo sapiens		 8.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96727&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			651919	164037971							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130340	CCN1CCN(c2cc(Nc3cc(CCc4ccc(F)c(NC(=O)c5cccc(C(F)(F)F)c5)c4)n[nH]3)nc(C)n2)CC1	InChI=1S/C30H32F4N8O/c1-3-41-11-13-42(14-12-41)28-18-26(35-19(2)36-28)38-27-17-23(39-40-27)9-7-20-8-10-24(31)25(15-20)37-29(43)21-5-4-6-22(16-21)30(32,33)34/h4-6,8,10,15-18H,3,7,9,11-14H2,1-2H3,(H,37,43)(H2,35,36,38,39,40)	RQKCTICSSCJUTN-UHFFFAOYSA-N	96728	N-(5-(2-(3-((6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)-2-fluorophenyl)-3-(trifluoromethyl) benzamide::US12509446, Compound 45	Tyrosine-protein kinase Fyn	Homo sapiens		 22.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96728&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			650715	164037972							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130341	Cc1nc(Nc2cc(CCc3ccc(F)c(NC(=O)c4cccc(C(F)(F)F)c4)c3)n[nH]2)cc(N2CC(O)C2)n1	InChI=1S/C27H25F4N7O2/c1-15-32-23(12-25(33-15)38-13-20(39)14-38)35-24-11-19(36-37-24)7-5-16-6-8-21(28)22(9-16)34-26(40)17-3-2-4-18(10-17)27(29,30)31/h2-4,6,8-12,20,39H,5,7,13-14H2,1H3,(H,34,40)(H2,32,33,35,36,37)	OEWXDJBXZIPDBJ-UHFFFAOYSA-N	96729	N-(2-fluoro-5-(2-(3-((6-(3-hydroxyazetidin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 46	Tyrosine-protein kinase Fyn	Homo sapiens		 18.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96729&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			1873525	164037973							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130342	CN(C)Cc1ccc(C(=O)Nc2cccc(CCc3cc(NC(=O)c4ccc(N5CCOCC5)cc4)[nH]n3)c2)cc1	InChI=1S/C32H36N6O3/c1-37(2)22-24-6-9-25(10-7-24)31(39)33-27-5-3-4-23(20-27)8-13-28-21-30(36-35-28)34-32(40)26-11-14-29(15-12-26)38-16-18-41-19-17-38/h3-7,9-12,14-15,20-21H,8,13,16-19,22H2,1-2H3,(H,33,39)(H2,34,35,36,40)	STQYDROKYSDFJX-UHFFFAOYSA-N	96730	US12509446, Compound 47	Tyrosine-protein kinase Fyn	Homo sapiens		 10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96730&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			2744683	164037974							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130343	Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1CCc1cnc(Nc2cnccn2)s1	InChI=1S/C24H23N5O3S2/c1-16-6-8-19(28-23(30)18-4-3-5-21(13-18)34(2,31)32)12-17(16)7-9-20-14-27-24(33-20)29-22-15-25-10-11-26-22/h3-6,8,10-15H,7,9H2,1-2H3,(H,28,30)(H,26,27,29)	KHNRBFZKJRRHEC-UHFFFAOYSA-N	96731	US12509446, Compound 48	Tyrosine-protein kinase Fyn	Homo sapiens		 27.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96731&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			2732263	164037975							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130344	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cnc(Nc2cnccn2)s1	InChI=1S/C24H20F3N5OS/c1-15-5-7-19(31-22(33)17-3-2-4-18(11-17)24(25,26)27)12-16(15)6-8-20-13-30-23(34-20)32-21-14-28-9-10-29-21/h2-5,7,9-14H,6,8H2,1H3,(H,31,33)(H,29,30,32)	WRLYUUVLRGLVJT-UHFFFAOYSA-N	96732	US12509446, Compound 49	Tyrosine-protein kinase Fyn	Homo sapiens		 143							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96732	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96732&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			2802350	164037976							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130345	Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1CCc1cnc(Nc2cnccn2)s1	InChI=1S/C26H25N7OS/c1-17-4-6-20(32-24(34)19-8-9-29-22(13-19)26(2,3)16-27)12-18(17)5-7-21-14-31-25(35-21)33-23-15-28-10-11-30-23/h4,6,8-15H,5,7H2,1-3H3,(H,32,34)(H,30,31,33)	VXPNSYQFAWJDGL-UHFFFAOYSA-N	96733	US12509446, Compound 50	Tyrosine-protein kinase Fyn	Homo sapiens		 8.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96733	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=8061&target=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96733&enzyme=Tyrosine-protein+kinase+Fyn&column=ki&startPg=0&Increment=50&submit=Search			2802347	164037977							1	MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL	2DQ7,10DJ	Tyrosine-protein kinase Fyn	FYN_HUMAN	P06241	B5BU57 E1P557 H0UI48 Q16248 Q5R3A6 Q5R3A7 Q8N5D7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130346	Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H24N6O3S/c1-16-6-8-19(27-24(31)18-4-3-5-21(13-18)34(2,32)33)12-17(16)7-9-20-14-22(30-29-20)28-23-15-25-10-11-26-23/h3-6,8,10-15H,7,9H2,1-2H3,(H,27,31)(H2,26,28,29,30)	JZKIVYDSXGDJOM-UHFFFAOYSA-N	96681	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(methylsulfonyl)benzamide::US12509446, Compound 1	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96681	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96681&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			16191234	164037925							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130347	Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C26H26N8O/c1-17-4-6-20(31-25(35)19-8-9-29-22(13-19)26(2,3)16-27)12-18(17)5-7-21-14-23(34-33-21)32-24-15-28-10-11-30-24/h4,6,8-15H,5,7H2,1-3H3,(H,31,35)(H2,30,32,33,34)	ULDPBEDPVNUHIM-UHFFFAOYSA-N	96682	2-(2-cyanopropan-2-yl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)isonicotinamide::US12509446, Compound 2	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96682	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96682&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			16191684	164037926							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130348	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H21F3N6O/c1-15-5-7-19(30-23(34)17-3-2-4-18(11-17)24(25,26)27)12-16(15)6-8-20-13-21(33-32-20)31-22-14-28-9-10-29-22/h2-5,7,9-14H,6,8H2,1H3,(H,30,34)(H2,29,31,32,33)	ULHMIFGFUPWWCR-UHFFFAOYSA-N	96683	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 3	Vascular endothelial growth factor receptor 2	Homo sapiens		 7.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96683&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			3112062	164037927							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130349	CCNC1(c2ccc(C(=O)Nc3ccc(C)c(CCc4cc(Nc5cnccn5)[nH]n4)c3)cc2)CC1	InChI=1S/C28H31N7O/c1-3-31-28(12-13-28)22-8-5-20(6-9-22)27(36)32-23-10-4-19(2)21(16-23)7-11-24-17-25(35-34-24)33-26-18-29-14-15-30-26/h4-6,8-10,14-18,31H,3,7,11-13H2,1-2H3,(H,32,36)(H2,30,33,34,35)	GRFUBQVMULOMFY-UHFFFAOYSA-N	96684	4-(1-(ethylamino)cyclopropyl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)benzamide::US12509446, Compound 4	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96684	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96684&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			2929978	164037928							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130350	Cc1ccc(NC(=O)c2ccnc(C(C)(C)O)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C25H27N7O2/c1-16-4-6-19(29-24(33)18-8-9-27-21(13-18)25(2,3)34)12-17(16)5-7-20-14-22(32-31-20)30-23-15-26-10-11-28-23/h4,6,8-15,34H,5,7H2,1-3H3,(H,29,33)(H2,28,30,31,32)	YDNHAHAXIKZEOE-UHFFFAOYSA-N	96685	2-(2-hydroxypropan-2-yl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)isonicotinamide::US12509446, Compound 5	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96685	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96685&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			1570021	164037929							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130351	Cc1nc(C(=O)Nc2ccc(C)c(CCc3cc(Nc4cnccn4)[nH]n3)c2)c(C(F)(F)F)o1	InChI=1S/C22H20F3N7O2/c1-12-3-5-15(29-21(33)19-20(22(23,24)25)34-13(2)28-19)9-14(12)4-6-16-10-17(32-31-16)30-18-11-26-7-8-27-18/h3,5,7-11H,4,6H2,1-2H3,(H,29,33)(H2,27,30,31,32)	OJCGTZDKMQRGBU-UHFFFAOYSA-N	96686	2-methyl-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-5-(trifluoromethyl)oxazole-4-carboxamide::US12509446, Compound 6	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96686	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96686&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			746603	164037930							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130352	Cc1ccc(NC(=O)c2cc(C(F)(F)F)ccc2F)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H20F4N6O/c1-14-2-5-17(31-23(35)19-11-16(24(26,27)28)4-7-20(19)25)10-15(14)3-6-18-12-21(34-33-18)32-22-13-29-8-9-30-22/h2,4-5,7-13H,3,6H2,1H3,(H,31,35)(H2,30,32,33,34)	UOMBLHAGLMPPDO-UHFFFAOYSA-N	96687	2-fluoro-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-5-(trifluoromethyl)benzamide::US12509446, Compound 7	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96687	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96687&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			22276	164037931							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130353	Cc1ccc(NC(=O)c2cc(S(=O)(=O)C3CC3)ccn2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C25H25N7O3S/c1-16-2-4-18(29-25(33)22-14-21(8-9-27-22)36(34,35)20-6-7-20)12-17(16)3-5-19-13-23(32-31-19)30-24-15-26-10-11-28-24/h2,4,8-15,20H,3,5-7H2,1H3,(H,29,33)(H2,28,30,31,32)	HTTQPYUEKMMVKV-UHFFFAOYSA-N	96688	4-(cyclopropylsulfonyl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)picolinamide::US12509446, Compound 8	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96688	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96688&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			1497794	164037932							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130354	CC(C)Cc1ccc(C(=O)Nc2ccc(F)c(CCc3cc(NC(=O)c4ncccn4)[nH]n3)c2)cn1	InChI=1S/C26H26FN7O2/c1-16(2)12-19-6-5-18(15-30-19)25(35)31-20-8-9-22(27)17(13-20)4-7-21-14-23(34-33-21)32-26(36)24-28-10-3-11-29-24/h3,5-6,8-11,13-16H,4,7,12H2,1-2H3,(H,31,35)(H2,32,33,34,36)	HNMJHYJMWUTAOI-UHFFFAOYSA-N	96689	N-(3-(2-fluoro-5-(6-isobutylnicotinamido)phenethyl)-1H-pyrazol-5-yl)pyrimidine-2-carboxamide::US12509446, Compound 9	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96689	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96689&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			6870484	164037933							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130355	O=C(Nc1ccc(F)c(CCc2cc(Nc3cc4c(cn3)CN(CCO)C4)[nH]n2)c1)c1cccc(C(F)(F)F)c1	InChI=1S/C28H26F4N6O2/c29-24-7-6-22(34-27(40)18-2-1-3-21(10-18)28(30,31)32)11-17(24)4-5-23-13-26(37-36-23)35-25-12-19-15-38(8-9-39)16-20(19)14-33-25/h1-3,6-7,10-14,39H,4-5,8-9,15-16H2,(H,34,40)(H2,33,35,36,37)	KWJWEAZZJUJTME-UHFFFAOYSA-N	96690	N-(4-fluoro-3-(2-(5-((2-(2-hydroxyethyl)-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 10	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96690	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96690&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			16193924	164037934							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130356	CC(C)(C#N)c1cc(C(=O)Nc2ccc(F)c(CCc3cc(Nc4cnccn4)[nH]n3)c2)ccn1	InChI=1S/C25H23FN8O/c1-25(2,15-27)21-12-17(7-8-29-21)24(35)31-18-5-6-20(26)16(11-18)3-4-19-13-22(34-33-19)32-23-14-28-9-10-30-23/h5-14H,3-4H2,1-2H3,(H,31,35)(H2,30,32,33,34)	XGLTXWNPJZJPHN-UHFFFAOYSA-N	96692	2-(2-cyanopropan-2-yl)-N-(4-fluoro-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)isonicotinamide::US12509446, Compound 11	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96692	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96692&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			718460	164037936							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130357	CS(=O)(=O)c1cccc(C(=O)Nc2ccc(F)c(CCc3cc(Nc4cnccn4)[nH]n3)c2)c1	InChI=1S/C23H21FN6O3S/c1-34(32,33)19-4-2-3-16(12-19)23(31)27-17-7-8-20(24)15(11-17)5-6-18-13-21(30-29-18)28-22-14-25-9-10-26-22/h2-4,7-14H,5-6H2,1H3,(H,27,31)(H2,26,28,29,30)	FYNJKZQYZXMOIR-UHFFFAOYSA-N	96693	N-(4-fluoro-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(methylsulfonyl)benzamide::US12509446, Compound 12	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96693	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96693&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			5890451	164037937							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130358	O=C(Nc1ccc(F)c(CCc2cc(Nc3cnccn3)[nH]n2)c1)c1cccc(C(F)(F)F)c1	InChI=1S/C23H18F4N6O/c24-19-7-6-17(30-22(34)15-2-1-3-16(10-15)23(25,26)27)11-14(19)4-5-18-12-20(33-32-18)31-21-13-28-8-9-29-21/h1-3,6-13H,4-5H2,(H,30,34)(H2,29,31,32,33)	OYWWVXPPTOSQMX-UHFFFAOYSA-N	96694	N-(4-fluoro-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl) benzamide::US12509446, Compound 13	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96694	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96694&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			16194546	164037938							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130359	Cc1cnc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)c(C)n1	InChI=1S/C25H22F4N6O/c1-14-13-30-23(15(2)31-14)33-22-12-20(34-35-22)7-6-16-11-19(8-9-21(16)26)32-24(36)17-4-3-5-18(10-17)25(27,28)29/h3-5,8-13H,6-7H2,1-2H3,(H,32,36)(H2,30,33,34,35)	BKJGGCGVBGNJTJ-UHFFFAOYSA-N	96695	N-(3-(2-(5-((3,5-dimethylpyrazin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 14	Vascular endothelial growth factor receptor 2	Homo sapiens		 10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96695	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96695&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			4416228	164037939							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130360	Cc1nccnc1Nc1cc(CCc2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2F)n[nH]1	InChI=1S/C24H20F4N6O/c1-14-22(30-10-9-29-14)32-21-13-19(33-34-21)6-5-15-12-18(7-8-20(15)25)31-23(35)16-3-2-4-17(11-16)24(26,27)28/h2-4,7-13H,5-6H2,1H3,(H,31,35)(H2,30,32,33,34)	QDOAHOIDZPGOTI-UHFFFAOYSA-N	96696	N-(4-fluoro-3-(2-(5-((3-methylpyrazin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 15	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96696	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96696&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			3960357	164037940							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130361	O=C(Nc1ccc(Cl)c(CCc2cc(Nc3cnccn3)[nH]n2)c1)c1cccc(C(F)(F)F)c1	InChI=1S/C23H18ClF3N6O/c24-19-7-6-17(30-22(34)15-2-1-3-16(10-15)23(25,26)27)11-14(19)4-5-18-12-20(33-32-18)31-21-13-28-8-9-29-21/h1-3,6-13H,4-5H2,(H,30,34)(H2,29,31,32,33)	HIWHDJFEPJAOJT-UHFFFAOYSA-N	96697	N-(4-chloro-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 16	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96697	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96697&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			2153989	164037941							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130362	CCN1Cc2cnc(Nc3cc(CCc4cc(NC(=O)c5cccc(C(F)(F)F)c5)ccc4C)n[nH]3)cc2C1	InChI=1S/C29H29F3N6O/c1-3-38-16-21-13-26(33-15-22(21)17-38)35-27-14-25(36-37-27)10-8-19-12-24(9-7-18(19)2)34-28(39)20-5-4-6-23(11-20)29(30,31)32/h4-7,9,11-15H,3,8,10,16-17H2,1-2H3,(H,34,39)(H2,33,35,36,37)	HQKHHGPVMMIKFH-UHFFFAOYSA-N	96698	N-(3-(2-(5-((2-ethyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-methylphenyl) -3-(trifluoromethyl)benzamide::US12509446, Compound 17	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96698	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96698&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			5716919	164037942							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130363	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(NC(=O)c2ccccn2)[nH]n1	InChI=1S/C26H22F3N5O2/c1-16-8-10-20(31-24(35)18-5-4-6-19(13-18)26(27,28)29)14-17(16)9-11-21-15-23(34-33-21)32-25(36)22-7-2-3-12-30-22/h2-8,10,12-15H,9,11H2,1H3,(H,31,35)(H2,32,33,34,36)	VDSROHNDKMIJSJ-UHFFFAOYSA-N	96699	N-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenethyl)-1H-pyrazol-3-yl)picolinamide::US12509446, Compound 18	Vascular endothelial growth factor receptor 2	Homo sapiens		 16.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96699	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96699&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			91899613	164037943							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130364	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(NC(=O)c2ccc(F)cc2)[nH]n1	InChI=1S/C27H22F4N4O2/c1-16-5-11-22(32-26(37)19-3-2-4-20(13-19)27(29,30)31)14-18(16)8-12-23-15-24(35-34-23)33-25(36)17-6-9-21(28)10-7-17/h2-7,9-11,13-15H,8,12H2,1H3,(H,32,37)(H2,33,34,35,36)	YCXFQTHSQSTPOU-UHFFFAOYSA-N	96700	N-(3-(2-(3-(4-fluorobenzamido)-1H-pyrazol-5-yl)ethyl)-4-methylphenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 19	Vascular endothelial growth factor receptor 2	Homo sapiens		 110							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96700	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96700&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			3787753	164037944							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130365	Cc1nc(CN2CCOCC2)cc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)[nH]n2)n1	InChI=1S/C29H29F4N7O2/c1-18-34-24(17-40-9-11-42-12-10-40)16-26(35-18)37-27-15-23(38-39-27)6-5-19-14-22(7-8-25(19)30)36-28(41)20-3-2-4-21(13-20)29(31,32)33/h2-4,7-8,13-16H,5-6,9-12,17H2,1H3,(H,36,41)(H2,34,35,37,38,39)	HYLAYVUXJLXEMK-UHFFFAOYSA-N	96707	N-(4-fluoro-3-(2-(3-((2-methyl-6-(morpholinomethyl)pyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 26	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96707	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96707&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			4879418	164037951							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130366	Cc1nc(CN2C[C@@H](C)O[C@@H](C)C2)cc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)[nH]n2)n1	InChI=1S/C31H33F4N7O2/c1-18-15-42(16-19(2)44-18)17-26-14-28(37-20(3)36-26)39-29-13-25(40-41-29)8-7-21-12-24(9-10-27(21)32)38-30(43)22-5-4-6-23(11-22)31(33,34)35/h4-6,9-14,18-19H,7-8,15-17H2,1-3H3,(H,38,43)(H2,36,37,39,40,41)	LJPJINRCHKNFIT-UHFFFAOYSA-N	96709	N-(3-(2-(3-((6-(((2S,6R)-2,6-dimethylmorpholino)methyl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 27	Vascular endothelial growth factor receptor 2	Homo sapiens		 12.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96709	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96709&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			5385994	164037953							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130367	Cc1nc(CN2CCCC2)cc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)[nH]n2)n1	InChI=1S/C29H29F4N7O/c1-18-34-24(17-40-11-2-3-12-40)16-26(35-18)37-27-15-23(38-39-27)8-7-19-14-22(9-10-25(19)30)36-28(41)20-5-4-6-21(13-20)29(31,32)33/h4-6,9-10,13-16H,2-3,7-8,11-12,17H2,1H3,(H,36,41)(H2,34,35,37,38,39)	MTADWLQFOMKPHV-UHFFFAOYSA-N	96710	N-(4-fluoro-3-(2-(3-((2-methyl-6-(pyrrolidin-1-ylmethyl)pyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 28	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96710	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96710&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			3856622	164037954							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130368	CCN1CCN(c2cc(Nc3cc(CCc4cc(NC(=O)c5cccc(C(F)(F)F)c5)ccc4F)n[nH]3)nc(C)n2)CC1	InChI=1S/C30H32F4N8O/c1-3-41-11-13-42(14-12-41)28-18-26(35-19(2)36-28)38-27-17-24(39-40-27)8-7-20-16-23(9-10-25(20)31)37-29(43)21-5-4-6-22(15-21)30(32,33)34/h4-6,9-10,15-18H,3,7-8,11-14H2,1-2H3,(H,37,43)(H2,35,36,38,39,40)	SIXIPLANITULIR-UHFFFAOYSA-N	96711	N-(3-(2-(3-((6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 29	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96711	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96711&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			751683	164037955							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130369	Cc1nc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)cc(N2CCN(CCO)CC2)n1	InChI=1S/C30H32F4N8O2/c1-19-35-26(18-28(36-19)42-11-9-41(10-12-42)13-14-43)38-27-17-24(39-40-27)6-5-20-16-23(7-8-25(20)31)37-29(44)21-3-2-4-22(15-21)30(32,33)34/h2-4,7-8,15-18,43H,5-6,9-14H2,1H3,(H,37,44)(H2,35,36,38,39,40)	DNKNEOHEQUZRGL-UHFFFAOYSA-N	96712	N-(4-fluoro-3-(2-(3-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl) benzamide::US12509446, Compound 30	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96712	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96712&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			16681852	164037956							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130370	Cc1nc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)cc(N2CC(O)C2)n1	InChI=1S/C27H25F4N7O2/c1-15-32-23(12-25(33-15)38-13-21(39)14-38)35-24-11-20(36-37-24)6-5-16-10-19(7-8-22(16)28)34-26(40)17-3-2-4-18(9-17)27(29,30)31/h2-4,7-12,21,39H,5-6,13-14H2,1H3,(H,34,40)(H2,32,33,35,36,37)	CSYKYDZYAZHBBD-UHFFFAOYSA-N	96713	N-(4-fluoro-3-(2-(3-((6-(3-hydroxyazetidin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 31	Vascular endothelial growth factor receptor 2	Homo sapiens		 18.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96713	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96713&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			6868679	164037957							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130371	Cc1nc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)cc(N2CC[C@H](N(C)C)C2)n1	InChI=1S/C30H32F4N8O/c1-18-35-26(16-28(36-18)42-12-11-24(17-42)41(2)3)38-27-15-23(39-40-27)8-7-19-14-22(9-10-25(19)31)37-29(43)20-5-4-6-21(13-20)30(32,33)34/h4-6,9-10,13-16,24H,7-8,11-12,17H2,1-3H3,(H,37,43)(H2,35,36,38,39,40)	BEPKLJSGBABDRT-UHFFFAOYSA-N	96714	(S)-N-(3-(2-(3-((6-(3-(dimethylamino)pyrrolidin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)-4-fluorophenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 32	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96714	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96714&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			5452969	164037958							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130372	Cc1ccc(NC(=O)c2cccc(C(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H22F2N6O/c1-15-5-7-19(29-24(33)18-4-2-3-17(11-18)23(25)26)12-16(15)6-8-20-13-21(32-31-20)30-22-14-27-9-10-28-22/h2-5,7,9-14,23H,6,8H2,1H3,(H,29,33)(H2,28,30,31,32)	RZZDYHJFXFRDOA-UHFFFAOYSA-N	96715	3-(difluoromethyl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl) benzamide::US12509446, Compound 33	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96715	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96715&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			6858937	164037959							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130373	CC(=O)N1Cc2cnc(Nc3cc(CCc4cc(NC(=O)c5cccc(C(F)F)c5)ccc4C)n[nH]3)cc2C1	InChI=1S/C29H28F2N6O2/c1-17-6-8-24(33-29(39)21-5-3-4-20(10-21)28(30)31)11-19(17)7-9-25-13-27(36-35-25)34-26-12-22-15-37(18(2)38)16-23(22)14-32-26/h3-6,8,10-14,28H,7,9,15-16H2,1-2H3,(H,33,39)(H2,32,34,35,36)	NCQNADCXUGRURC-UHFFFAOYSA-N	96716	N-(3-(2-(5-((2-acetyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-methylphenyl)-3-(trifluoromethyl) benzamide::US12509446, Compound 34	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96716	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96716&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			91899615	164037960							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130374	Cc1ccc(NC(=O)c2cccc(S(=O)(=O)C(C)C)c2)cc1CCc1cc(Nc2ncccc2C)[nH]n1	InChI=1S/C28H31N5O3S/c1-18(2)37(35,36)25-9-5-8-22(16-25)28(34)30-23-12-10-19(3)21(15-23)11-13-24-17-26(33-32-24)31-27-20(4)7-6-14-29-27/h5-10,12,14-18H,11,13H2,1-4H3,(H,30,34)(H2,29,31,32,33)	ZGIULFTYFSFGOA-UHFFFAOYSA-N	96717	3-(isopropylsulfonyl)-N-(4-methyl-3-(2-(5-((3-methylpyridin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl) benzamide::US12509446, Compound 35	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96717	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96717&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			5517140	164037961							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130375	Cc1ccc(NC(=O)c2ccnc(C(C)(C)C#N)c2)cc1CCc1cc(Nc2ncccc2C)[nH]n1	InChI=1S/C28H29N7O/c1-18-7-9-22(32-27(36)21-11-13-30-24(15-21)28(3,4)17-29)14-20(18)8-10-23-16-25(35-34-23)33-26-19(2)6-5-12-31-26/h5-7,9,11-16H,8,10H2,1-4H3,(H,32,36)(H2,31,33,34,35)	WLLGIRVDLYIHFD-UHFFFAOYSA-N	96718	2-(2-cyanopropan-2-yl)-N-(4-methyl-3-(2-(5-((3-methylpyridin-2-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)isonicotinamide::US12509446, Compound 36	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96718	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96718&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			751678	164037962							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130376	Cc1nc(C#N)cc(Nc2cc(CCc3cc(NC(=O)c4cccc(S(=O)(=O)N(C)C)c4)ccc3C)n[nH]2)n1	InChI=1S/C27H28N8O3S/c1-17-8-10-21(31-27(36)20-6-5-7-24(13-20)39(37,38)35(3)4)12-19(17)9-11-22-14-26(34-33-22)32-25-15-23(16-28)29-18(2)30-25/h5-8,10,12-15H,9,11H2,1-4H3,(H,31,36)(H2,29,30,32,33,34)	SDHXJWIEOAKZCF-UHFFFAOYSA-N	96719	N-(3-(2-(5-((6-cyano-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-methylphenyl)-3-(N,N-dimethylsulfamoyl)benzamide::US12509446, Compound 37	Vascular endothelial growth factor receptor 2	Homo sapiens		 35.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96719	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96719&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			6869784	164037963							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130377	Cc1nc(C#N)cc(Nc2cc(CCc3cc(NC(=O)c4ccc(CN(C)C)c(C(F)(F)F)c4)ccc3F)n[nH]2)n1	InChI=1S/C28H26F4N8O/c1-16-34-22(14-33)13-25(35-16)37-26-12-21(38-39-26)7-6-17-10-20(8-9-24(17)29)36-27(41)18-4-5-19(15-40(2)3)23(11-18)28(30,31)32/h4-5,8-13H,6-7,15H2,1-3H3,(H,36,41)(H2,34,35,37,38,39)	QAGDHLTUULNQQP-UHFFFAOYSA-N	96721	N-(3-(2-(5-((6-cyano-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-3-yl)ethyl)-4-fluorophenyl)-4-((dimethylamino) methyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 39	Vascular endothelial growth factor receptor 2	Homo sapiens		 11.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96721	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96721&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			751676	164037965							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130378	Cc1ncc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)n[nH]2)cn1	InChI=1S/C24H20F4N6O/c1-14-29-12-20(13-30-14)31-22-11-19(33-34-22)6-5-15-10-18(7-8-21(15)25)32-23(35)16-3-2-4-17(9-16)24(26,27)28/h2-4,7-13H,5-6H2,1H3,(H,32,35)(H2,31,33,34)	ZVYQPQAIHVRYCF-UHFFFAOYSA-N	96722	N-(4-fluoro-3-(2-(5-((2-methylpyrimidin-5-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoro methyl)benzamide::US12509446, Compound 40	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96722	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96722&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			751698	164037966							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130379	Cc1ccc(NC(=O)c2cc(C(C)(C)C#N)ccn2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C26H26N8O/c1-17-4-6-20(31-25(35)22-13-19(8-9-29-22)26(2,3)16-27)12-18(17)5-7-21-14-23(34-33-21)32-24-15-28-10-11-30-24/h4,6,8-15H,5,7H2,1-3H3,(H,31,35)(H2,30,32,33,34)	VAWMENKWNNMTSN-UHFFFAOYSA-N	96723	4-(2-cyanopropan-2-yl)-N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)picolinamide::US12509446, Compound 41	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96723	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96723&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			5357791	164037967							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130380	Cc1nc(Nc2cc(CCc3cc(NC(=O)c4cccc(C(F)(F)F)c4)ccc3F)[nH]n2)cc(C2C=NN(CCO)C2)n1	InChI=1S/C29H28F4N8O2/c1-17-35-25(20-15-34-41(16-20)9-10-42)14-26(36-17)38-27-13-23(39-40-27)6-5-18-12-22(7-8-24(18)30)37-28(43)19-3-2-4-21(11-19)29(31,32)33/h2-4,7-8,11-15,20,42H,5-6,9-10,16H2,1H3,(H,37,43)(H2,35,36,38,39,40)	FAKWGXAMVZSCFX-UHFFFAOYSA-N	96724	N-(4-fluoro-3-(2-(3-((6-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)-2-methylpyrimidin-4-yl) amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 42	Vascular endothelial growth factor receptor 2	Homo sapiens		 20.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96724	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96724&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			344197	164037968							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130381	Cc1nc(Nc2cc(CCc3ccc(F)c(NC(=O)c4cccc(C(F)(F)F)c4)c3)n[nH]2)cc(N2CCOCC2)n1	InChI=1S/C28H27F4N7O2/c1-17-33-24(16-26(34-17)39-9-11-41-12-10-39)36-25-15-21(37-38-25)7-5-18-6-8-22(29)23(13-18)35-27(40)19-3-2-4-20(14-19)28(30,31)32/h2-4,6,8,13-16H,5,7,9-12H2,1H3,(H,35,40)(H2,33,34,36,37,38)	YAIMXASJMPAVJA-UHFFFAOYSA-N	96726	N-(2-fluoro-5-(2-(5-((2-methyl-6-morpholinopyrimidin-4-yl)amino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 43	Vascular endothelial growth factor receptor 2	Homo sapiens		 10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96726	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96726&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			241200	164037970							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130382	Cc1nc(Nc2cc(CCc3ccc(F)c(NC(=O)c4cccc(C(F)(F)F)c4)c3)n[nH]2)cc(N2CCN(CCO)CC2)n1	InChI=1S/C30H32F4N8O2/c1-19-35-26(18-28(36-19)42-11-9-41(10-12-42)13-14-43)38-27-17-23(39-40-27)7-5-20-6-8-24(31)25(15-20)37-29(44)21-3-2-4-22(16-21)30(32,33)34/h2-4,6,8,15-18,43H,5,7,9-14H2,1H3,(H,37,44)(H2,35,36,38,39,40)	MAESUCGGNZJRTC-UHFFFAOYSA-N	96727	N-(2-fluoro-5-(2-(3-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl) ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 44	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96727	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96727&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			651919	164037971							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130383	CCN1CCN(c2cc(Nc3cc(CCc4ccc(F)c(NC(=O)c5cccc(C(F)(F)F)c5)c4)n[nH]3)nc(C)n2)CC1	InChI=1S/C30H32F4N8O/c1-3-41-11-13-42(14-12-41)28-18-26(35-19(2)36-28)38-27-17-23(39-40-27)9-7-20-8-10-24(31)25(15-20)37-29(43)21-5-4-6-22(16-21)30(32,33)34/h4-6,8,10,15-18H,3,7,9,11-14H2,1-2H3,(H,37,43)(H2,35,36,38,39,40)	RQKCTICSSCJUTN-UHFFFAOYSA-N	96728	N-(5-(2-(3-((6-(4-ethylpiperazin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)-2-fluorophenyl)-3-(trifluoromethyl) benzamide::US12509446, Compound 45	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96728	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96728&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			650715	164037972							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130384	Cc1nc(Nc2cc(CCc3ccc(F)c(NC(=O)c4cccc(C(F)(F)F)c4)c3)n[nH]2)cc(N2CC(O)C2)n1	InChI=1S/C27H25F4N7O2/c1-15-32-23(12-25(33-15)38-13-20(39)14-38)35-24-11-19(36-37-24)7-5-16-6-8-21(28)22(9-16)34-26(40)17-3-2-4-18(10-17)27(29,30)31/h2-4,6,8-12,20,39H,5,7,13-14H2,1H3,(H,34,40)(H2,32,33,35,36,37)	OEWXDJBXZIPDBJ-UHFFFAOYSA-N	96729	N-(2-fluoro-5-(2-(3-((6-(3-hydroxyazetidin-1-yl)-2-methylpyrimidin-4-yl)amino)-1H-pyrazol-5-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 46	Vascular endothelial growth factor receptor 2	Homo sapiens		<10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96729	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96729&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			1873525	164037973							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130385	CN(C)Cc1ccc(C(=O)Nc2cccc(CCc3cc(NC(=O)c4ccc(N5CCOCC5)cc4)[nH]n3)c2)cc1	InChI=1S/C32H36N6O3/c1-37(2)22-24-6-9-25(10-7-24)31(39)33-27-5-3-4-23(20-27)8-13-28-21-30(36-35-28)34-32(40)26-11-14-29(15-12-26)38-16-18-41-19-17-38/h3-7,9-12,14-15,20-21H,8,13,16-19,22H2,1-2H3,(H,33,39)(H2,34,35,36,40)	STQYDROKYSDFJX-UHFFFAOYSA-N	96730	US12509446, Compound 47	Vascular endothelial growth factor receptor 2	Homo sapiens		 10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96730	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96730&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			2744683	164037974							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130386	Cc1ccc(NC(=O)c2cccc(S(C)(=O)=O)c2)cc1CCc1cnc(Nc2cnccn2)s1	InChI=1S/C24H23N5O3S2/c1-16-6-8-19(28-23(30)18-4-3-5-21(13-18)34(2,31)32)12-17(16)7-9-20-14-27-24(33-20)29-22-15-25-10-11-26-22/h3-6,8,10-15H,7,9H2,1-2H3,(H,28,30)(H,26,27,29)	KHNRBFZKJRRHEC-UHFFFAOYSA-N	96731	US12509446, Compound 48	Vascular endothelial growth factor receptor 2	Homo sapiens		 10.00							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96731	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=692&target=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96731&enzyme=Vascular+endothelial+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			2732263	164037975							1	MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWDSKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVSCMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYSSEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV	3V2A,1Y6B,1Y6A,3VHE,3VID,3C7Q,5OYJ	Vascular endothelial growth factor receptor 2	VGFR2_HUMAN	P35968	A2RRS0 B5A925 C5IFA0 O60723 Q14178																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130387	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H21F3N6O/c1-15-5-7-19(30-23(34)17-3-2-4-18(11-17)24(25,26)27)12-16(15)6-8-20-13-21(33-32-20)31-22-14-28-9-10-29-22/h2-5,7,9-14H,6,8H2,1H3,(H,30,34)(H2,29,31,32,33)	ULHMIFGFUPWWCR-UHFFFAOYSA-N	96683	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 3	Tyrosine-protein kinase Lyn	Homo sapiens		 59.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5481&target=Tyrosine-protein+kinase+Lyn&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96683&enzyme=Tyrosine-protein+kinase+Lyn&column=ki&startPg=0&Increment=50&submit=Search			3112062	164037927							1	MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP	3A4O,5XY1,4TZI	Tyrosine-protein kinase Lyn	LYN_HUMAN	P07948	A0AVQ5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130388	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H21F3N6O/c1-15-5-7-19(30-23(34)17-3-2-4-18(11-17)24(25,26)27)12-16(15)6-8-20-13-21(33-32-20)31-22-14-28-9-10-29-22/h2-5,7,9-14H,6,8H2,1H3,(H,30,34)(H2,29,31,32,33)	ULHMIFGFUPWWCR-UHFFFAOYSA-N	96683	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 3	Tyrosine-protein kinase Yes	Homo sapiens		 17.0							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5424&target=Tyrosine-protein+kinase+Yes&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96683&enzyme=Tyrosine-protein+kinase+Yes&column=ki&startPg=0&Increment=50&submit=Search			3112062	164037927							1	MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL	1YOM,1YOJ,4LGG	Tyrosine-protein kinase Yes	YES_HUMAN	P07947	A6NLB3 D3DUH1																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130389	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H21F3N6O/c1-15-5-7-19(30-23(34)17-3-2-4-18(11-17)24(25,26)27)12-16(15)6-8-20-13-21(33-32-20)31-22-14-28-9-10-29-22/h2-5,7,9-14H,6,8H2,1H3,(H,30,34)(H2,29,31,32,33)	ULHMIFGFUPWWCR-UHFFFAOYSA-N	96683	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 3	Proto-oncogene tyrosine-protein kinase Src	Homo sapiens		 370							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=13&target=Proto-oncogene+tyrosine-protein+kinase+Src&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96683&enzyme=Proto-oncogene+tyrosine-protein+kinase+Src&column=ki&startPg=0&Increment=50&submit=Search			3112062	164037927							1	MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL	8JN9,8JN8,2H8H,2SRC,1Y57,1FMK,2PTK,9NS0,8JF3,6ATE,4MXO,4MXX,2BDJ,2BDF,8HAQ,6E6E,1YI6	Proto-oncogene tyrosine-protein kinase Src	SRC_HUMAN	P12931	E1P5V4 Q76P87 Q86VB9 Q9H5A8																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130390	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H21F3N6O/c1-15-5-7-19(30-23(34)17-3-2-4-18(11-17)24(25,26)27)12-16(15)6-8-20-13-21(33-32-20)31-22-14-28-9-10-29-22/h2-5,7,9-14H,6,8H2,1H3,(H,30,34)(H2,29,31,32,33)	ULHMIFGFUPWWCR-UHFFFAOYSA-N	96683	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 3	Tyrosine-protein kinase JAK3	Homo sapiens		 1760							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=4919&target=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96683&enzyme=Tyrosine-protein+kinase+JAK3&column=ki&startPg=0&Increment=50&submit=Search			3112062	164037927							1	MAPPSEETPLIPQRSCSLLSTEAGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGLEKCHRFGLRKDLASAILDLPVLEHLFAQHRSDLVSGRLPVGLSLKEQGECLSLAVLDLARMAREQAQRPGELLKTVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVAACQADRHSLMAKYIMDLERLDPAGAAETFHVGLPGALGGHDGLGLLRVAGDGGIAWTQGEQEVLQPFCDFPEIVDISIKQAPRVGPAGEHRLVTVTRTDNQILEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSPTGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS	7C3N,3PJC,6DUD,6DB4,6DB3,6DA4,5TTV,5TTU,5TTS,5TOZ	Tyrosine-protein kinase JAK3	JAK3_HUMAN	P52333	Q13259 Q13260 Q13611 Q8N1E8 Q99699 Q9Y6S2			N/A	A0A024R7M7																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																														
130391	Cc1ccc(NC(=O)c2cccc(C(F)(F)F)c2)cc1CCc1cc(Nc2cnccn2)[nH]n1	InChI=1S/C24H21F3N6O/c1-15-5-7-19(30-23(34)17-3-2-4-18(11-17)24(25,26)27)12-16(15)6-8-20-13-21(33-32-20)31-22-14-28-9-10-29-22/h2-5,7,9-14H,6,8H2,1H3,(H,30,34)(H2,29,31,32,33)	ULHMIFGFUPWWCR-UHFFFAOYSA-N	96683	N-(4-methyl-3-(2-(5-(pyrazin-2-ylamino)-1H-pyrazol-3-yl)ethyl)phenyl)-3-(trifluoromethyl)benzamide::US12509446, Compound 3	Fibroblast growth factor receptor 2	Homo sapiens		 3000							US Patent		10.7270/Q2FN1C1K			US12509446	Rovati, LC; Caselli, G; Artusi, R; Mennuni, L; Colace, F; Mandelli, S; Bovino, C; Magaraci, F; Buzzi, B	12/30/2025	5/11/2026	Rottapharm Biotech	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96683	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=856&target=Fibroblast+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96683&enzyme=Fibroblast+growth+factor+receptor+2&column=ki&startPg=0&Increment=50&submit=Search			3112062	164037927							1	MVSWGRFICLVVVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEVYVAAPGESLEVRCLLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACTASRTVDSETWYFMVNVTDAISSGDDEDDTDGAEDFVSENSNNKRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCVVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVNTTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYCIGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT	2PSQ,1OEC,1GJO,8STG,5EG3,6LVL,6LVK,8H75,9U7S,9U7E,9VLM,7OZY,8YKI,1EV2,1E0O,1DJS	Fibroblast growth factor receptor 2	FGFR2_HUMAN	P21802	B4DFC2 E7EVR6 E9PCR0 P18443 Q01742 Q12922 Q14300 Q14301 Q14302 Q14303 Q14304 Q14305 Q14672 Q14718 Q14719 Q1KHY5 Q86YI4 Q8IXC7 Q96KL9 Q96KM0 Q96KM1 Q96KM2 Q9NZU2 Q9NZU3 Q9UD01 Q9UD02 Q9UIH3 Q9UIH4 Q9UIH5 Q9UIH6 Q9UIH7 Q9UIH8 Q9UM87 Q9UMC6 Q9UNS7 Q9UQH7 Q9UQH8 Q9UQH9 Q9UQI0