BindingDB Reactant_set_id	Ligand SMILES	Ligand InChI	Ligand InChI Key	BindingDB MonomerID	BindingDB Ligand Name	Target Name	Target Source Organism According to Curator or DataSource	Ki (nM)	IC50 (nM)	Kd (nM)	EC50 (nM)	kon (M-1-s-1)	koff (s-1)	pH	Temp (C)	Curation/DataSource	Article DOI	BindingDB Entry DOI	PMID	PubChem AID	Patent Number	Authors	Date of publication	Date in BindingDB	Institution	Link to Ligand in BindingDB	Link to Target in BindingDB	Link to Ligand-Target Pair in BindingDB	Ligand HET ID in PDB	PDB ID(s) for Ligand-Target Complex	PubChem CID	PubChem SID	ChEBI ID of Ligand	ChEMBL ID of Ligand	DrugBank ID of Ligand	IUPHAR_GRAC ID of Ligand	KEGG ID of Ligand	ZINC ID of Ligand	Number of Protein Chains in Target (>1 implies a multichain complex)	BindingDB Target Chain Sequence 1	PDB ID(s) of Target Chain 1	UniProt (SwissProt) Recommended Name of Target Chain 1	UniProt (SwissProt) Entry Name of Target Chain 1	UniProt (SwissProt) Primary ID of Target Chain 1	UniProt (SwissProt) Secondary ID(s) of Target Chain 1	UniProt (SwissProt) Alternative ID(s) of Target Chain 1	UniProt (TrEMBL) Submitted Name of Target Chain 1	UniProt (TrEMBL) Entry Name of Target Chain 1	UniProt (TrEMBL) Primary ID of Target Chain 1	UniProt (TrEMBL) Secondary ID(s) of Target Chain 1	UniProt (TrEMBL) Alternative ID(s) of Target Chain 1	BindingDB Target Chain Sequence 2	PDB ID(s) of Target Chain 2	UniProt (SwissProt) Recommended Name of Target Chain 2	UniProt (SwissProt) Entry Name of Target Chain 2	UniProt (SwissProt) Primary ID of Target Chain 2	UniProt (SwissProt) Secondary ID(s) of Target Chain 2	UniProt (SwissProt) Alternative ID(s) of Target Chain 2	UniProt (TrEMBL) Submitted Name of Target Chain 2	UniProt (TrEMBL) Entry Name of Target Chain 2	UniProt (TrEMBL) Primary ID of Target Chain 2	UniProt (TrEMBL) Secondary ID(s) of Target Chain 2	UniProt (TrEMBL) Alternative ID(s) of Target Chain 2	BindingDB Target Chain Sequence 3	PDB ID(s) of Target Chain 3	UniProt (SwissProt) Recommended Name of Target Chain 3	UniProt (SwissProt) Entry Name of Target Chain 3	UniProt (SwissProt) Primary ID of Target Chain 3	UniProt (SwissProt) Secondary ID(s) of Target Chain 3	UniProt (SwissProt) Alternative ID(s) of Target Chain 3	UniProt (TrEMBL) Submitted Name of Target Chain 3	UniProt (TrEMBL) Entry Name of Target Chain 3	UniProt (TrEMBL) Primary ID of Target Chain 3	UniProt (TrEMBL) Secondary ID(s) of Target Chain 3	UniProt (TrEMBL) Alternative ID(s) of Target Chain 3	BindingDB Target Chain Sequence 4	PDB ID(s) of Target Chain 4	UniProt (SwissProt) Recommended Name of Target Chain 4	UniProt (SwissProt) Entry Name of Target Chain 4	UniProt (SwissProt) Primary ID of Target Chain 4	UniProt (SwissProt) Secondary ID(s) of Target Chain 4	UniProt (SwissProt) Alternative ID(s) of Target Chain 4	UniProt (TrEMBL) Submitted Name of Target Chain 4	UniProt (TrEMBL) Entry Name of Target Chain 4	UniProt (TrEMBL) Primary ID of Target Chain 4	UniProt (TrEMBL) Secondary ID(s) of Target Chain 4	UniProt (TrEMBL) Alternative ID(s) of Target Chain 4	BindingDB Target Chain Sequence 5	PDB ID(s) of Target Chain 5	UniProt (SwissProt) Recommended Name of Target Chain 5	UniProt (SwissProt) Entry Name of Target Chain 5	UniProt (SwissProt) Primary ID of Target Chain 5	UniProt (SwissProt) Secondary ID(s) of Target Chain 5	UniProt (SwissProt) Alternative ID(s) of Target Chain 5	UniProt (TrEMBL) Submitted Name of Target Chain 5	UniProt (TrEMBL) Entry Name of Target Chain 5	UniProt (TrEMBL) Primary ID of Target Chain 5	UniProt (TrEMBL) Secondary ID(s) of Target Chain 5	UniProt (TrEMBL) Alternative ID(s) of Target Chain 5	BindingDB Target Chain Sequence 6	PDB ID(s) of Target Chain 6	UniProt (SwissProt) Recommended Name of Target Chain 6	UniProt (SwissProt) Entry Name of Target Chain 6	UniProt (SwissProt) Primary ID of Target Chain 6	UniProt (SwissProt) Secondary ID(s) of Target Chain 6	UniProt (SwissProt) Alternative ID(s) of Target Chain 6	UniProt (TrEMBL) Submitted Name of Target Chain 6	UniProt (TrEMBL) Entry Name of Target Chain 6	UniProt (TrEMBL) Primary ID of Target Chain 6	UniProt (TrEMBL) Secondary ID(s) of Target Chain 6	UniProt (TrEMBL) Alternative ID(s) of Target Chain 6	BindingDB Target Chain Sequence 7	PDB ID(s) of Target Chain 7	UniProt (SwissProt) Recommended Name of Target Chain 7	UniProt (SwissProt) Entry Name of Target Chain 7	UniProt (SwissProt) Primary ID of Target Chain 7	UniProt (SwissProt) Secondary ID(s) of Target Chain 7	UniProt (SwissProt) Alternative ID(s) of Target Chain 7	UniProt (TrEMBL) Submitted Name of Target Chain 7	UniProt (TrEMBL) Entry Name of Target Chain 7	UniProt (TrEMBL) Primary ID of Target Chain 7	UniProt (TrEMBL) Secondary ID(s) of Target Chain 7	UniProt (TrEMBL) Alternative ID(s) of Target Chain 7	BindingDB Target Chain Sequence 8	PDB ID(s) of Target Chain 8	UniProt (SwissProt) Recommended Name of Target Chain 8	UniProt (SwissProt) Entry Name of Target Chain 8	UniProt (SwissProt) Primary ID of Target Chain 8	UniProt (SwissProt) Secondary ID(s) of Target Chain 8	UniProt (SwissProt) Alternative ID(s) of Target Chain 8	UniProt (TrEMBL) Submitted Name of Target Chain 8	UniProt (TrEMBL) Entry Name of Target Chain 8	UniProt (TrEMBL) Primary ID of Target Chain 8	UniProt (TrEMBL) Secondary ID(s) of Target Chain 8	UniProt (TrEMBL) Alternative ID(s) of Target Chain 8	BindingDB Target Chain Sequence 9	PDB ID(s) of Target Chain 9	UniProt (SwissProt) Recommended Name of Target Chain 9	UniProt (SwissProt) Entry Name of Target Chain 9	UniProt (SwissProt) Primary ID of Target Chain 9	UniProt (SwissProt) Secondary ID(s) of Target Chain 9	UniProt (SwissProt) Alternative ID(s) of Target Chain 9	UniProt (TrEMBL) Submitted Name of Target Chain 9	UniProt (TrEMBL) Entry Name of Target Chain 9	UniProt (TrEMBL) Primary ID of Target Chain 9	UniProt (TrEMBL) Secondary ID(s) of Target Chain 9	UniProt (TrEMBL) Alternative ID(s) of Target Chain 9	BindingDB Target Chain Sequence 10	PDB ID(s) of Target Chain 10	UniProt (SwissProt) Recommended Name of Target Chain 10	UniProt (SwissProt) Entry Name of Target Chain 10	UniProt (SwissProt) Primary ID of Target Chain 10	UniProt (SwissProt) Secondary ID(s) of Target Chain 10	UniProt (SwissProt) Alternative ID(s) of Target Chain 10	UniProt (TrEMBL) Submitted Name of Target Chain 10	UniProt (TrEMBL) Entry Name of Target Chain 10	UniProt (TrEMBL) Primary ID of Target Chain 10	UniProt (TrEMBL) Secondary ID(s) of Target Chain 10	UniProt (TrEMBL) Alternative ID(s) of Target Chain 10	BindingDB Target Chain Sequence 11	PDB ID(s) of Target Chain 11	UniProt (SwissProt) Recommended Name of Target Chain 11	UniProt (SwissProt) Entry Name of Target Chain 11	UniProt (SwissProt) Primary ID of Target Chain 11	UniProt (SwissProt) Secondary ID(s) of Target Chain 11	UniProt (SwissProt) Alternative ID(s) of Target Chain 11	UniProt (TrEMBL) Submitted Name of Target Chain 11	UniProt (TrEMBL) Entry Name of Target Chain 11	UniProt (TrEMBL) Primary ID of Target Chain 11	UniProt (TrEMBL) Secondary ID(s) of Target Chain 11	UniProt (TrEMBL) Alternative ID(s) of Target Chain 11	BindingDB Target Chain Sequence 12	PDB ID(s) of Target Chain 12	UniProt (SwissProt) Recommended Name of Target Chain 12	UniProt (SwissProt) Entry Name of Target Chain 12	UniProt (SwissProt) Primary ID of Target Chain 12	UniProt (SwissProt) Secondary ID(s) of Target Chain 12	UniProt (SwissProt) Alternative ID(s) of Target Chain 12	UniProt (TrEMBL) Submitted Name of Target Chain 12	UniProt (TrEMBL) Entry Name of Target Chain 12	UniProt (TrEMBL) Primary ID of Target Chain 12	UniProt (TrEMBL) Secondary ID(s) of Target Chain 12	UniProt (TrEMBL) Alternative ID(s) of Target Chain 12	BindingDB Target Chain Sequence 13	PDB ID(s) of Target Chain 13	UniProt (SwissProt) Recommended Name of Target Chain 13	UniProt (SwissProt) Entry Name of Target Chain 13	UniProt (SwissProt) Primary ID of Target Chain 13	UniProt (SwissProt) Secondary ID(s) of Target Chain 13	UniProt (SwissProt) Alternative ID(s) of Target Chain 13	UniProt (TrEMBL) Submitted Name of Target Chain 13	UniProt (TrEMBL) Entry Name of Target Chain 13	UniProt (TrEMBL) Primary ID of Target Chain 13	UniProt (TrEMBL) Secondary ID(s) of Target Chain 13	UniProt (TrEMBL) Alternative ID(s) of Target Chain 13	BindingDB Target Chain Sequence 14	PDB ID(s) of Target Chain 14	UniProt (SwissProt) Recommended Name of Target Chain 14	UniProt (SwissProt) Entry Name of Target Chain 14	UniProt (SwissProt) Primary ID of Target Chain 14	UniProt (SwissProt) Secondary ID(s) of Target Chain 14	UniProt (SwissProt) Alternative ID(s) of Target Chain 14	UniProt (TrEMBL) Submitted Name of Target Chain 14	UniProt (TrEMBL) Entry Name of Target Chain 14	UniProt (TrEMBL) Primary ID of Target Chain 14	UniProt (TrEMBL) Secondary ID(s) of Target Chain 14	UniProt (TrEMBL) Alternative ID(s) of Target Chain 14	BindingDB Target Chain Sequence 15	PDB ID(s) of Target Chain 15	UniProt (SwissProt) Recommended Name of Target Chain 15	UniProt (SwissProt) Entry Name of Target Chain 15	UniProt (SwissProt) Primary ID of Target Chain 15	UniProt (SwissProt) Secondary ID(s) of Target Chain 15	UniProt (SwissProt) Alternative ID(s) of Target Chain 15	UniProt (TrEMBL) Submitted Name of Target Chain 15	UniProt (TrEMBL) Entry Name of Target Chain 15	UniProt (TrEMBL) Primary ID of Target Chain 15	UniProt (TrEMBL) Secondary ID(s) of Target Chain 15	UniProt (TrEMBL) Alternative ID(s) of Target Chain 15	BindingDB Target Chain Sequence 16	PDB ID(s) of Target Chain 16	UniProt (SwissProt) Recommended Name of Target Chain 16	UniProt (SwissProt) Entry Name of Target Chain 16	UniProt (SwissProt) Primary ID of Target Chain 16	UniProt (SwissProt) Secondary ID(s) of Target Chain 16	UniProt (SwissProt) Alternative ID(s) of Target Chain 16	UniProt (TrEMBL) Submitted Name of Target Chain 16	UniProt (TrEMBL) Entry Name of Target Chain 16	UniProt (TrEMBL) Primary ID of Target Chain 16	UniProt (TrEMBL) Secondary ID(s) of Target Chain 16	UniProt (TrEMBL) Alternative ID(s) of Target Chain 16	BindingDB Target Chain Sequence 17	PDB ID(s) of Target Chain 17	UniProt (SwissProt) Recommended Name of Target Chain 17	UniProt (SwissProt) Entry Name of Target Chain 17	UniProt (SwissProt) Primary ID of Target Chain 17	UniProt (SwissProt) Secondary ID(s) of Target Chain 17	UniProt (SwissProt) Alternative ID(s) of Target Chain 17	UniProt (TrEMBL) Submitted Name of Target Chain 17	UniProt (TrEMBL) Entry Name of Target Chain 17	UniProt (TrEMBL) Primary ID of Target Chain 17	UniProt (TrEMBL) Secondary ID(s) of Target Chain 17	UniProt (TrEMBL) Alternative ID(s) of Target Chain 17	BindingDB Target Chain Sequence 18	PDB ID(s) of Target Chain 18	UniProt (SwissProt) Recommended Name of Target Chain 18	UniProt (SwissProt) Entry Name of Target Chain 18	UniProt (SwissProt) Primary ID of Target Chain 18	UniProt (SwissProt) Secondary ID(s) of Target Chain 18	UniProt (SwissProt) Alternative ID(s) of Target Chain 18	UniProt (TrEMBL) Submitted Name of Target Chain 18	UniProt (TrEMBL) Entry Name of Target Chain 18	UniProt (TrEMBL) Primary ID of Target Chain 18	UniProt (TrEMBL) Secondary ID(s) of Target Chain 18	UniProt (TrEMBL) Alternative ID(s) of Target Chain 18	BindingDB Target Chain Sequence 19	PDB ID(s) of Target Chain 19	UniProt (SwissProt) Recommended Name of Target Chain 19	UniProt (SwissProt) Entry Name of Target Chain 19	UniProt (SwissProt) Primary ID of Target Chain 19	UniProt (SwissProt) Secondary ID(s) of Target Chain 19	UniProt (SwissProt) Alternative ID(s) of Target Chain 19	UniProt (TrEMBL) Submitted Name of Target Chain 19	UniProt (TrEMBL) Entry Name of Target Chain 19	UniProt (TrEMBL) Primary ID of Target Chain 19	UniProt (TrEMBL) Secondary ID(s) of Target Chain 19	UniProt (TrEMBL) Alternative ID(s) of Target Chain 19	BindingDB Target Chain Sequence 20	PDB ID(s) of Target Chain 20	UniProt (SwissProt) Recommended Name of Target Chain 20	UniProt (SwissProt) Entry Name of Target Chain 20	UniProt (SwissProt) Primary ID of Target Chain 20	UniProt (SwissProt) Secondary ID(s) of Target Chain 20	UniProt (SwissProt) Alternative ID(s) of Target Chain 20	UniProt (TrEMBL) Submitted Name of Target Chain 20	UniProt (TrEMBL) Entry Name of Target Chain 20	UniProt (TrEMBL) Primary ID of Target Chain 20	UniProt (TrEMBL) Secondary ID(s) of Target Chain 20	UniProt (TrEMBL) Alternative ID(s) of Target Chain 20	BindingDB Target Chain Sequence 21	PDB ID(s) of Target Chain 21	UniProt (SwissProt) Recommended Name of Target Chain 21	UniProt (SwissProt) Entry Name of Target Chain 21	UniProt (SwissProt) Primary ID of Target Chain 21	UniProt (SwissProt) Secondary ID(s) of Target Chain 21	UniProt (SwissProt) Alternative ID(s) of Target Chain 21	UniProt (TrEMBL) Submitted Name of Target Chain 21	UniProt (TrEMBL) Entry Name of Target Chain 21	UniProt (TrEMBL) Primary ID of Target Chain 21	UniProt (TrEMBL) Secondary ID(s) of Target Chain 21	UniProt (TrEMBL) Alternative ID(s) of Target Chain 21	BindingDB Target Chain Sequence 22	PDB ID(s) of Target Chain 22	UniProt (SwissProt) Recommended Name of Target Chain 22	UniProt (SwissProt) Entry Name of Target Chain 22	UniProt (SwissProt) Primary ID of Target Chain 22	UniProt (SwissProt) Secondary ID(s) of Target Chain 22	UniProt (SwissProt) Alternative ID(s) of Target Chain 22	UniProt (TrEMBL) Submitted Name of Target Chain 22	UniProt (TrEMBL) Entry Name of Target Chain 22	UniProt (TrEMBL) Primary ID of Target Chain 22	UniProt (TrEMBL) Secondary ID(s) of Target Chain 22	UniProt (TrEMBL) Alternative ID(s) of Target Chain 22	BindingDB Target Chain Sequence 23	PDB ID(s) of Target Chain 23	UniProt (SwissProt) Recommended Name of Target Chain 23	UniProt (SwissProt) Entry Name of Target Chain 23	UniProt (SwissProt) Primary ID of Target Chain 23	UniProt (SwissProt) Secondary ID(s) of Target Chain 23	UniProt (SwissProt) Alternative ID(s) of Target Chain 23	UniProt (TrEMBL) Submitted Name of Target Chain 23	UniProt (TrEMBL) Entry Name of Target Chain 23	UniProt (TrEMBL) Primary ID of Target Chain 23	UniProt (TrEMBL) Secondary ID(s) of Target Chain 23	UniProt (TrEMBL) Alternative ID(s) of Target Chain 23	BindingDB Target Chain Sequence 24	PDB ID(s) of Target Chain 24	UniProt (SwissProt) Recommended Name of Target Chain 24	UniProt (SwissProt) Entry Name of Target Chain 24	UniProt (SwissProt) Primary ID of Target Chain 24	UniProt (SwissProt) Secondary ID(s) of Target Chain 24	UniProt (SwissProt) Alternative ID(s) of Target Chain 24	UniProt (TrEMBL) Submitted Name of Target Chain 24	UniProt (TrEMBL) Entry Name of Target Chain 24	UniProt (TrEMBL) Primary ID of Target Chain 24	UniProt (TrEMBL) Secondary ID(s) of Target Chain 24	UniProt (TrEMBL) Alternative ID(s) of Target Chain 24	BindingDB Target Chain Sequence 25	PDB ID(s) of Target Chain 25	UniProt (SwissProt) Recommended Name of Target Chain 25	UniProt (SwissProt) Entry Name of Target Chain 25	UniProt (SwissProt) Primary ID of Target Chain 25	UniProt (SwissProt) Secondary ID(s) of Target Chain 25	UniProt (SwissProt) Alternative ID(s) of Target Chain 25	UniProt (TrEMBL) Submitted Name of Target Chain 25	UniProt (TrEMBL) Entry Name of Target Chain 25	UniProt (TrEMBL) Primary ID of Target Chain 25	UniProt (TrEMBL) Secondary ID(s) of Target Chain 25	UniProt (TrEMBL) Alternative ID(s) of Target Chain 25	BindingDB Target Chain Sequence 26	PDB ID(s) of Target Chain 26	UniProt (SwissProt) Recommended Name of Target Chain 26	UniProt (SwissProt) Entry Name of Target Chain 26	UniProt (SwissProt) Primary ID of Target Chain 26	UniProt (SwissProt) Secondary ID(s) of Target Chain 26	UniProt (SwissProt) Alternative ID(s) of Target Chain 26	UniProt (TrEMBL) Submitted Name of Target Chain 26	UniProt (TrEMBL) Entry Name of Target Chain 26	UniProt (TrEMBL) Primary ID of Target Chain 26	UniProt (TrEMBL) Secondary ID(s) of Target Chain 26	UniProt (TrEMBL) Alternative ID(s) of Target Chain 26	BindingDB Target Chain Sequence 27	PDB ID(s) of Target Chain 27	UniProt (SwissProt) Recommended Name of Target Chain 27	UniProt (SwissProt) Entry Name of Target Chain 27	UniProt (SwissProt) Primary ID of Target Chain 27	UniProt (SwissProt) Secondary ID(s) of Target Chain 27	UniProt (SwissProt) Alternative ID(s) of Target Chain 27	UniProt (TrEMBL) Submitted Name of Target Chain 27	UniProt (TrEMBL) Entry Name of Target Chain 27	UniProt (TrEMBL) Primary ID of Target Chain 27	UniProt (TrEMBL) Secondary ID(s) of Target Chain 27	UniProt (TrEMBL) Alternative ID(s) of Target Chain 27	BindingDB Target Chain Sequence 28	PDB ID(s) of Target Chain 28	UniProt (SwissProt) Recommended Name of Target Chain 28	UniProt (SwissProt) Entry Name of Target Chain 28	UniProt (SwissProt) Primary ID of Target Chain 28	UniProt (SwissProt) Secondary ID(s) of Target Chain 28	UniProt (SwissProt) Alternative ID(s) of Target Chain 28	UniProt (TrEMBL) Submitted Name of Target Chain 28	UniProt (TrEMBL) Entry Name of Target Chain 28	UniProt (TrEMBL) Primary ID of Target Chain 28	UniProt (TrEMBL) Secondary ID(s) of Target Chain 28	UniProt (TrEMBL) Alternative ID(s) of Target Chain 28	BindingDB Target Chain Sequence 29	PDB ID(s) of Target Chain 29	UniProt (SwissProt) Recommended Name of Target Chain 29	UniProt (SwissProt) Entry Name of Target Chain 29	UniProt (SwissProt) Primary ID of Target Chain 29	UniProt (SwissProt) Secondary ID(s) of Target Chain 29	UniProt (SwissProt) Alternative ID(s) of Target Chain 29	UniProt (TrEMBL) Submitted Name of Target Chain 29	UniProt (TrEMBL) Entry Name of Target Chain 29	UniProt (TrEMBL) Primary ID of Target Chain 29	UniProt (TrEMBL) Secondary ID(s) of Target Chain 29	UniProt (TrEMBL) Alternative ID(s) of Target Chain 29	BindingDB Target Chain Sequence 30	PDB ID(s) of Target Chain 30	UniProt (SwissProt) Recommended Name of Target Chain 30	UniProt (SwissProt) Entry Name of Target Chain 30	UniProt (SwissProt) Primary ID of Target Chain 30	UniProt (SwissProt) Secondary ID(s) of Target Chain 30	UniProt (SwissProt) Alternative ID(s) of Target Chain 30	UniProt (TrEMBL) Submitted Name of Target Chain 30	UniProt (TrEMBL) Entry Name of Target Chain 30	UniProt (TrEMBL) Primary ID of Target Chain 30	UniProt (TrEMBL) Secondary ID(s) of Target Chain 30	UniProt (TrEMBL) Alternative ID(s) of Target Chain 30	BindingDB Target Chain Sequence 31	PDB ID(s) of Target Chain 31	UniProt (SwissProt) Recommended Name of Target Chain 31	UniProt (SwissProt) Entry Name of Target Chain 31	UniProt (SwissProt) Primary ID of Target Chain 31	UniProt (SwissProt) Secondary ID(s) of Target Chain 31	UniProt (SwissProt) Alternative ID(s) of Target Chain 31	UniProt (TrEMBL) Submitted Name of Target Chain 31	UniProt (TrEMBL) Entry Name of Target Chain 31	UniProt (TrEMBL) Primary ID of Target Chain 31	UniProt (TrEMBL) Secondary ID(s) of Target Chain 31	UniProt (TrEMBL) Alternative ID(s) of Target Chain 31	BindingDB Target Chain Sequence 32	PDB ID(s) of Target Chain 32	UniProt (SwissProt) Recommended Name of Target Chain 32	UniProt (SwissProt) Entry Name of Target Chain 32	UniProt (SwissProt) Primary ID of Target Chain 32	UniProt (SwissProt) Secondary ID(s) of Target Chain 32	UniProt (SwissProt) Alternative ID(s) of Target Chain 32	UniProt (TrEMBL) Submitted Name of Target Chain 32	UniProt (TrEMBL) Entry Name of Target Chain 32	UniProt (TrEMBL) Primary ID of Target Chain 32	UniProt (TrEMBL) Secondary ID(s) of Target Chain 32	UniProt (TrEMBL) Alternative ID(s) of Target Chain 32	BindingDB Target Chain Sequence 33	PDB ID(s) of Target Chain 33	UniProt (SwissProt) Recommended Name of Target Chain 33	UniProt (SwissProt) Entry Name of Target Chain 33	UniProt (SwissProt) Primary ID of Target Chain 33	UniProt (SwissProt) Secondary ID(s) of Target Chain 33	UniProt (SwissProt) Alternative ID(s) of Target Chain 33	UniProt (TrEMBL) Submitted Name of Target Chain 33	UniProt (TrEMBL) Entry Name of Target Chain 33	UniProt (TrEMBL) Primary ID of Target Chain 33	UniProt (TrEMBL) Secondary ID(s) of Target Chain 33	UniProt (TrEMBL) Alternative ID(s) of Target Chain 33	BindingDB Target Chain Sequence 34	PDB ID(s) of Target Chain 34	UniProt (SwissProt) Recommended Name of Target Chain 34	UniProt (SwissProt) Entry Name of Target Chain 34	UniProt (SwissProt) Primary ID of Target Chain 34	UniProt (SwissProt) Secondary ID(s) of Target Chain 34	UniProt (SwissProt) Alternative ID(s) of Target Chain 34	UniProt (TrEMBL) Submitted Name of Target Chain 34	UniProt (TrEMBL) Entry Name of Target Chain 34	UniProt (TrEMBL) Primary ID of Target Chain 34	UniProt (TrEMBL) Secondary ID(s) of Target Chain 34	UniProt (TrEMBL) Alternative ID(s) of Target Chain 34	BindingDB Target Chain Sequence 35	PDB ID(s) of Target Chain 35	UniProt (SwissProt) Recommended Name of Target Chain 35	UniProt (SwissProt) Entry Name of Target Chain 35	UniProt (SwissProt) Primary ID of Target Chain 35	UniProt (SwissProt) Secondary ID(s) of Target Chain 35	UniProt (SwissProt) Alternative ID(s) of Target Chain 35	UniProt (TrEMBL) Submitted Name of Target Chain 35	UniProt (TrEMBL) Entry Name of Target Chain 35	UniProt (TrEMBL) Primary ID of Target Chain 35	UniProt (TrEMBL) Secondary ID(s) of Target Chain 35	UniProt (TrEMBL) Alternative ID(s) of Target Chain 35	BindingDB Target Chain Sequence 36	PDB ID(s) of Target Chain 36	UniProt (SwissProt) Recommended Name of Target Chain 36	UniProt (SwissProt) Entry Name of Target Chain 36	UniProt (SwissProt) Primary ID of Target Chain 36	UniProt (SwissProt) Secondary ID(s) of Target Chain 36	UniProt (SwissProt) Alternative ID(s) of Target Chain 36	UniProt (TrEMBL) Submitted Name of Target Chain 36	UniProt (TrEMBL) Entry Name of Target Chain 36	UniProt (TrEMBL) Primary ID of Target Chain 36	UniProt (TrEMBL) Secondary ID(s) of Target Chain 36	UniProt (TrEMBL) Alternative ID(s) of Target Chain 36	BindingDB Target Chain Sequence 37	PDB ID(s) of Target Chain 37	UniProt (SwissProt) Recommended Name of Target Chain 37	UniProt (SwissProt) Entry Name of Target Chain 37	UniProt (SwissProt) Primary ID of Target Chain 37	UniProt (SwissProt) Secondary ID(s) of Target Chain 37	UniProt (SwissProt) Alternative ID(s) of Target Chain 37	UniProt (TrEMBL) Submitted Name of Target Chain 37	UniProt (TrEMBL) Entry Name of Target Chain 37	UniProt (TrEMBL) Primary ID of Target Chain 37	UniProt (TrEMBL) Secondary ID(s) of Target Chain 37	UniProt (TrEMBL) Alternative ID(s) of Target Chain 37	BindingDB Target Chain Sequence 38	PDB ID(s) of Target Chain 38	UniProt (SwissProt) Recommended Name of Target Chain 38	UniProt (SwissProt) Entry Name of Target Chain 38	UniProt (SwissProt) Primary ID of Target Chain 38	UniProt (SwissProt) Secondary ID(s) of Target Chain 38	UniProt (SwissProt) Alternative ID(s) of Target Chain 38	UniProt (TrEMBL) Submitted Name of Target Chain 38	UniProt (TrEMBL) Entry Name of Target Chain 38	UniProt (TrEMBL) Primary ID of Target Chain 38	UniProt (TrEMBL) Secondary ID(s) of Target Chain 38	UniProt (TrEMBL) Alternative ID(s) of Target Chain 38	BindingDB Target Chain Sequence 39	PDB ID(s) of Target Chain 39	UniProt (SwissProt) Recommended Name of Target Chain 39	UniProt (SwissProt) Entry Name of Target Chain 39	UniProt (SwissProt) Primary ID of Target Chain 39	UniProt (SwissProt) Secondary ID(s) of Target Chain 39	UniProt (SwissProt) Alternative ID(s) of Target Chain 39	UniProt (TrEMBL) Submitted Name of Target Chain 39	UniProt (TrEMBL) Entry Name of Target Chain 39	UniProt (TrEMBL) Primary ID of Target Chain 39	UniProt (TrEMBL) Secondary ID(s) of Target Chain 39	UniProt (TrEMBL) Alternative ID(s) of Target Chain 39	BindingDB Target Chain Sequence 40	PDB ID(s) of Target Chain 40	UniProt (SwissProt) Recommended Name of Target Chain 40	UniProt (SwissProt) Entry Name of Target Chain 40	UniProt (SwissProt) Primary ID of Target Chain 40	UniProt (SwissProt) Secondary ID(s) of Target Chain 40	UniProt (SwissProt) Alternative ID(s) of Target Chain 40	UniProt (TrEMBL) Submitted Name of Target Chain 40	UniProt (TrEMBL) Entry Name of Target Chain 40	UniProt (TrEMBL) Primary ID of Target Chain 40	UniProt (TrEMBL) Secondary ID(s) of Target Chain 40	UniProt (TrEMBL) Alternative ID(s) of Target Chain 40	BindingDB Target Chain Sequence 41	PDB ID(s) of Target Chain 41	UniProt (SwissProt) Recommended Name of Target Chain 41	UniProt (SwissProt) Entry Name of Target Chain 41	UniProt (SwissProt) Primary ID of Target Chain 41	UniProt (SwissProt) Secondary ID(s) of Target Chain 41	UniProt (SwissProt) Alternative ID(s) of Target Chain 41	UniProt (TrEMBL) Submitted Name of Target Chain 41	UniProt (TrEMBL) Entry Name of Target Chain 41	UniProt (TrEMBL) Primary ID of Target Chain 41	UniProt (TrEMBL) Secondary ID(s) of Target Chain 41	UniProt (TrEMBL) Alternative ID(s) of Target Chain 41	BindingDB Target Chain Sequence 42	PDB ID(s) of Target Chain 42	UniProt (SwissProt) Recommended Name of Target Chain 42	UniProt (SwissProt) Entry Name of Target Chain 42	UniProt (SwissProt) Primary ID of Target Chain 42	UniProt (SwissProt) Secondary ID(s) of Target Chain 42	UniProt (SwissProt) Alternative ID(s) of Target Chain 42	UniProt (TrEMBL) Submitted Name of Target Chain 42	UniProt (TrEMBL) Entry Name of Target Chain 42	UniProt (TrEMBL) Primary ID of Target Chain 42	UniProt (TrEMBL) Secondary ID(s) of Target Chain 42	UniProt (TrEMBL) Alternative ID(s) of Target Chain 42	BindingDB Target Chain Sequence 43	PDB ID(s) of Target Chain 43	UniProt (SwissProt) Recommended Name of Target Chain 43	UniProt (SwissProt) Entry Name of Target Chain 43	UniProt (SwissProt) Primary ID of Target Chain 43	UniProt (SwissProt) Secondary ID(s) of Target Chain 43	UniProt (SwissProt) Alternative ID(s) of Target Chain 43	UniProt (TrEMBL) Submitted Name of Target Chain 43	UniProt (TrEMBL) Entry Name of Target Chain 43	UniProt (TrEMBL) Primary ID of Target Chain 43	UniProt (TrEMBL) Secondary ID(s) of Target Chain 43	UniProt (TrEMBL) Alternative ID(s) of Target Chain 43	BindingDB Target Chain Sequence 44	PDB ID(s) of Target Chain 44	UniProt (SwissProt) Recommended Name of Target Chain 44	UniProt (SwissProt) Entry Name of Target Chain 44	UniProt (SwissProt) Primary ID of Target Chain 44	UniProt (SwissProt) Secondary ID(s) of Target Chain 44	UniProt (SwissProt) Alternative ID(s) of Target Chain 44	UniProt (TrEMBL) Submitted Name of Target Chain 44	UniProt (TrEMBL) Entry Name of Target Chain 44	UniProt (TrEMBL) Primary ID of Target Chain 44	UniProt (TrEMBL) Secondary ID(s) of Target Chain 44	UniProt (TrEMBL) Alternative ID(s) of Target Chain 44	BindingDB Target Chain Sequence 45	PDB ID(s) of Target Chain 45	UniProt (SwissProt) Recommended Name of Target Chain 45	UniProt (SwissProt) Entry Name of Target Chain 45	UniProt (SwissProt) Primary ID of Target Chain 45	UniProt (SwissProt) Secondary ID(s) of Target Chain 45	UniProt (SwissProt) Alternative ID(s) of Target Chain 45	UniProt (TrEMBL) Submitted Name of Target Chain 45	UniProt (TrEMBL) Entry Name of Target Chain 45	UniProt (TrEMBL) Primary ID of Target Chain 45	UniProt (TrEMBL) Secondary ID(s) of Target Chain 45	UniProt (TrEMBL) Alternative ID(s) of Target Chain 45	BindingDB Target Chain Sequence 46	PDB ID(s) of Target Chain 46	UniProt (SwissProt) Recommended Name of Target Chain 46	UniProt (SwissProt) Entry Name of Target Chain 46	UniProt (SwissProt) Primary ID of Target Chain 46	UniProt (SwissProt) Secondary ID(s) of Target Chain 46	UniProt (SwissProt) Alternative ID(s) of Target Chain 46	UniProt (TrEMBL) Submitted Name of Target Chain 46	UniProt (TrEMBL) Entry Name of Target Chain 46	UniProt (TrEMBL) Primary ID of Target Chain 46	UniProt (TrEMBL) Secondary ID(s) of Target Chain 46	UniProt (TrEMBL) Alternative ID(s) of Target Chain 46	BindingDB Target Chain Sequence 47	PDB ID(s) of Target Chain 47	UniProt (SwissProt) Recommended Name of Target Chain 47	UniProt (SwissProt) Entry Name of Target Chain 47	UniProt (SwissProt) Primary ID of Target Chain 47	UniProt (SwissProt) Secondary ID(s) of Target Chain 47	UniProt (SwissProt) Alternative ID(s) of Target Chain 47	UniProt (TrEMBL) Submitted Name of Target Chain 47	UniProt (TrEMBL) Entry Name of Target Chain 47	UniProt (TrEMBL) Primary ID of Target Chain 47	UniProt (TrEMBL) Secondary ID(s) of Target Chain 47	UniProt (TrEMBL) Alternative ID(s) of Target Chain 47	BindingDB Target Chain Sequence 48	PDB ID(s) of Target Chain 48	UniProt (SwissProt) Recommended Name of Target Chain 48	UniProt (SwissProt) Entry Name of Target Chain 48	UniProt (SwissProt) Primary ID of Target Chain 48	UniProt (SwissProt) Secondary ID(s) of Target Chain 48	UniProt (SwissProt) Alternative ID(s) of Target Chain 48	UniProt (TrEMBL) Submitted Name of Target Chain 48	UniProt (TrEMBL) Entry Name of Target Chain 48	UniProt (TrEMBL) Primary ID of Target Chain 48	UniProt (TrEMBL) Secondary ID(s) of Target Chain 48	UniProt (TrEMBL) Alternative ID(s) of Target Chain 48	BindingDB Target Chain Sequence 49	PDB ID(s) of Target Chain 49	UniProt (SwissProt) Recommended Name of Target Chain 49	UniProt (SwissProt) Entry Name of Target Chain 49	UniProt (SwissProt) Primary ID of Target Chain 49	UniProt (SwissProt) Secondary ID(s) of Target Chain 49	UniProt (SwissProt) Alternative ID(s) of Target Chain 49	UniProt (TrEMBL) Submitted Name of Target Chain 49	UniProt (TrEMBL) Entry Name of Target Chain 49	UniProt (TrEMBL) Primary ID of Target Chain 49	UniProt (TrEMBL) Secondary ID(s) of Target Chain 49	UniProt (TrEMBL) Alternative ID(s) of Target Chain 49	BindingDB Target Chain Sequence 50	PDB ID(s) of Target Chain 50	UniProt (SwissProt) Recommended Name of Target Chain 50	UniProt (SwissProt) Entry Name of Target Chain 50	UniProt (SwissProt) Primary ID of Target Chain 50	UniProt (SwissProt) Secondary ID(s) of Target Chain 50	UniProt (SwissProt) Alternative ID(s) of Target Chain 50	UniProt (TrEMBL) Submitted Name of Target Chain 50	UniProt (TrEMBL) Entry Name of Target Chain 50	UniProt (TrEMBL) Primary ID of Target Chain 50	UniProt (TrEMBL) Secondary ID(s) of Target Chain 50	UniProt (TrEMBL) Alternative ID(s) of Target Chain 50
130392	O=C(Nc1nnc(OCc2ccc(F)cc2)s1)c1cccnc1N1CCOCC1	InChI=1S/C19H18FN5O3S/c20-14-5-3-13(4-6-14)12-28-19-24-23-18(29-19)22-17(26)15-2-1-7-21-16(15)25-8-10-27-11-9-25/h1-7H,8-12H2,(H,22,23,26)	CIPDIHGMZQFWAE-UHFFFAOYSA-N	96734	N-(5-((4-fluorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-morpholinonicotinamide::US12509454, Compound 1	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96734	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96734&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2812763	164037978					C06374		1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130393	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCOCC1	InChI=1S/C19H18ClN5O3S/c20-14-5-3-13(4-6-14)12-28-19-24-23-18(29-19)22-17(26)15-2-1-7-21-16(15)25-8-10-27-11-9-25/h1-7H,8-12H2,(H,22,23,26)	MDPFTXFWUTWEIA-UHFFFAOYSA-N	96735	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-morpholinonicotinamide::US12509454, Compound 2	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96735	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96735&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6156965	164037979							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130394	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cccnc1N1CCOCC1	InChI=1S/C18H17ClN6O3S/c19-12-3-4-13(21-10-12)11-28-18-24-23-17(29-18)22-16(26)14-2-1-5-20-15(14)25-6-8-27-9-7-25/h1-5,10H,6-9,11H2,(H,22,23,26)	RLMVUYAGPBKMCV-UHFFFAOYSA-N	96737	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-2-morpholinonicotinamide::US12509454, Compound 3	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96737	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96737&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16746008	164037981							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130395	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cncn1-c1ccccc1	InChI=1S/C19H14ClN5O2S/c20-14-8-6-13(7-9-14)11-27-19-24-23-18(28-19)22-17(26)16-10-21-12-25(16)15-4-2-1-3-5-15/h1-10,12H,11H2,(H,22,23,26)	SVVJXALKBPAXKI-UHFFFAOYSA-N	96738	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-phenyl-1H-imidazole-5-carboxamide::US12509454, Compound 4	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96738	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96738&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16746098	164037982							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130396	CC1COCCN1c1ncccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H20ClN5O3S/c1-13-11-28-10-9-26(13)17-16(3-2-8-22-17)18(27)23-19-24-25-20(30-19)29-12-14-4-6-15(21)7-5-14/h2-8,13H,9-12H2,1H3,(H,23,24,27)	YFEBXQABIGYFTI-UHFFFAOYSA-N	96739	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(3-methymethylmorpholino) nicotinamide::US12509454, Compound 5	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96739	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96739&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16746161	164037983							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130397	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCCOCC1	InChI=1S/C20H20ClN5O3S/c21-15-6-4-14(5-7-15)13-29-20-25-24-19(30-20)23-18(27)16-3-1-8-22-17(16)26-9-2-11-28-12-10-26/h1,3-8H,2,9-13H2,(H,23,24,27)	XAVGIQZYAMNYSJ-UHFFFAOYSA-N	96740	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(1,4-oxazepan-4-yl)nicotinamide::US12509454, Compound 6	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96740	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96740&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			23641152	164037984							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130398	CC1CN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)CCO1	InChI=1S/C20H20ClN5O3S/c1-13-11-26(9-10-28-13)17-16(3-2-8-22-17)18(27)23-19-24-25-20(30-19)29-12-14-4-6-15(21)7-5-14/h2-8,13H,9-12H2,1H3,(H,23,24,27)	FJTXAPOUVPPYSD-UHFFFAOYSA-N	96741	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(2-methylmorpholino)nicotinamide::US12509454, Compound 7	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96741	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96741&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			597015	164037985							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130399	O=C(Nc1nnc(OCc2ccc(Cl)nc2)s1)c1cccnc1N1CCOCC1	InChI=1S/C18H17ClN6O3S/c19-14-4-3-12(10-21-14)11-28-18-24-23-17(29-18)22-16(26)13-2-1-5-20-15(13)25-6-8-27-9-7-25/h1-5,10H,6-9,11H2,(H,22,23,26)	BLMRCUXUMKBZAW-UHFFFAOYSA-N	96742	N-(5-((6-chloropyridin-3-yl)methoxy)-1,3,4- thiadiazol-2-yl)-2-morpholinonicotinamide::US12509454, Compound 8	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96742	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96742&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3697211	164037986							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130400	C[C@@H]1COCCN1c1ncccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H20ClN5O3S/c1-13-11-28-10-9-26(13)17-16(3-2-8-22-17)18(27)23-19-24-25-20(30-19)29-12-14-4-6-15(21)7-5-14/h2-8,13H,9-12H2,1H3,(H,23,24,27)	YFEBXQABIGYFTI-UHFFFAOYSA-N	96743	(R)-N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-(3- methylmorpholino)nicotinamide::US12509454, Compound 9	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96743	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96743&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			4127040	164037987							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130401	C[C@H]1COCCN1c1ncccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H20ClN5O3S/c1-13-11-28-10-9-26(13)17-16(3-2-8-22-17)18(27)23-19-24-25-20(30-19)29-12-14-4-6-15(21)7-5-14/h2-8,13H,9-12H2,1H3,(H,23,24,27)	YFEBXQABIGYFTI-UHFFFAOYSA-N	96744	(S)-N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-(3- methylmorpholmo)nicotinamide::US12509454, Compound 10	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96744	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96744&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2184768	164037988							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130402	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1-n1cnnn1	InChI=1S/C16H11ClN8O2S/c17-11-5-3-10(4-6-11)8-27-16-22-21-15(28-16)20-14(26)12-2-1-7-18-13(12)25-9-19-23-24-25/h1-7,9H,8H2,(H,20,21,26)	ZYTOYUQCIVCDPG-UHFFFAOYSA-N	96745	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(1H-tetrazol-1-yl)nicotinamide::US12509454, Compound 11	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96745	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96745&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			91899616	164037989							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130403	COc1ccc(-n2cncc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cc1	InChI=1S/C20H16ClN5O3S/c1-28-16-8-6-15(7-9-16)26-12-22-10-17(26)18(27)23-19-24-25-20(30-19)29-11-13-2-4-14(21)5-3-13/h2-10,12H,11H2,1H3,(H,23,24,27)	KIPNOKPKFAFMSH-UHFFFAOYSA-N	96746	N-(5-((4-chlorobenzyl)oxy)-1,3-4-thiadiazol- 2-yl)-1-(4-methoxyphenyl)-1H-imidazole-5- carboxamide::US12509454, Compound 12	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96746	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96746&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6468911	164037990							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130404	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cncnc1N1CCOCC1	InChI=1S/C18H17ClN6O3S/c19-13-3-1-12(2-4-13)10-28-18-24-23-17(29-18)22-16(26)14-9-20-11-21-15(14)25-5-7-27-8-6-25/h1-4,9,11H,5-8,10H2,(H,22,23,26)	QCJCBBVWSDLJCE-UHFFFAOYSA-N	96747	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-4-morpholinopyrimidine-5-carboxamide::US12509454, Compound 13	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96747	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96747&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2231358	164037991							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130405	N#Cc4ccc(C(=O)Nc2nnc(OCc1ccc(Cl)cc1)s2)c(N3CCOCC3)n4	InChI=1S/C20H17ClN6O3S/c21-14-3-1-13(2-4-14)12-30-20-26-25-19(31-20)24-18(28)16-6-5-15(11-22)23-17(16)27-7-9-29-10-8-27/h1-6H,7-10,12H2,(H,24,25,28)	MHVKHOLEUJWEKY-UHFFFAOYSA-N	96748	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-cyano-2-morpholinonicotinamide::US12509454, Compound 14	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96748	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96748&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2230320	164037992							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130406	O=C(Nc1nnc(OCc2ccc(Br)cn2)s1)c1cccnc1N1CCOCC1	InChI=1S/C18H17BrN6O3S/c19-12-3-4-13(21-10-12)11-28-18-24-23-17(29-18)22-16(26)14-2-1-5-20-15(14)25-6-8-27-9-7-25/h1-5,10H,6-9,11H2,(H,22,23,26)	YWHGTRBMLGFXIK-UHFFFAOYSA-N	96749	N-(5-((5-bromopyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-2-morpholinonicotinamide::US12509454, Compound 15	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96749	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96749&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6469989	164037993							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130407	CC(=O)N1CCN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)CC1	InChI=1S/C21H21ClN6O3S/c1-14(29)27-9-11-28(12-10-27)18-17(3-2-8-23-18)19(30)24-20-25-26-21(32-20)31-13-15-4-6-16(22)7-5-15/h2-8H,9-13H2,1H3,(H,24,25,30)	JGKAJNYKGSYNKW-UHFFFAOYSA-N	96750	2-(4-acetylpiperazin-1-yl)-N-(5-((4- chlorobenzyl)oxy)-1,3,4-thiadiazol-2- yl)nicotinamide::US12509454, Compound 16	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96750	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96750&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3563178	164037994							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130408	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cncn1-c1cccnc1	InChI=1S/C18H13ClN6O2S/c19-13-5-3-12(4-6-13)10-27-18-24-23-17(28-18)22-16(26)15-9-21-11-25(15)14-2-1-7-20-8-14/h1-9,11H,10H2,(H,22,23,26)	CUNLCMOZRNCJHN-UHFFFAOYSA-N	96751	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(pyridin-3-yl)-1H-imidazole-5- carboxamide::US12509454, Compound 17	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96751	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96751&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			5124934	164037995							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130409	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cncn1-c1ccncc1	InChI=1S/C18H13ClN6O2S/c19-13-3-1-12(2-4-13)10-27-18-24-23-17(28-18)22-16(26)15-9-21-11-25(15)14-5-7-20-8-6-14/h1-9,11H,10H2,(H,22,23,26)	JSFMQMFRKAEVHD-UHFFFAOYSA-N	96752	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(pyridin-4-yl)-1H-imidazole-5- carboxamide::US12509454, Compound 18	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96752	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96752&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			734782	164037996							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130410	O=C(Nc1nnc(OCc2cnc(Cl)cn2)s1)c1cccnc1N1CCOCC1	InChI=1S/C17H16ClN7O3S/c18-13-9-20-11(8-21-13)10-28-17-24-23-16(29-17)22-15(26)12-2-1-3-19-14(12)25-4-6-27-7-5-25/h1-3,8-9H,4-7,10H2,(H,22,23,26)	FBCYGVUEAWVAJK-UHFFFAOYSA-N	96753	N-(5-((5-chloropyrazin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-2-morpholinonicotinamide::US12509454, Compound 19	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96753	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96753&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1377226	164037997							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130411	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCC(O)CC1	InChI=1S/C20H20ClN5O3S/c21-14-5-3-13(4-6-14)12-29-20-25-24-19(30-20)23-18(28)16-2-1-9-22-17(16)26-10-7-15(27)8-11-26/h1-6,9,15,27H,7-8,10-12H2,(H,23,24,28)	WPHAVHLTMBPASK-UHFFFAOYSA-N	96754	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-2-(4-hydroxypiperidin-1- yl)nicotinamide::US12509454, Compound 20	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96754	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96754&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1139755	164037998							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130412	NC(=O)c1ccc(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c(N2CCOCC2)n1	InChI=1S/C20H19ClN6O4S/c21-13-3-1-12(2-4-13)11-31-20-26-25-19(32-20)24-18(29)14-5-6-15(16(22)28)23-17(14)27-7-9-30-10-8-27/h1-6H,7-11H2,(H2,22,28)(H,24,25,29)	ZGSNLPVQDCETIH-UHFFFAOYSA-N	96755	N5-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-morpholinopyridine-2,5- dicarboxamide::US12509454, Compound 21	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96755	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96755&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3176403	164037999							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130413	C[C@@H]1COCCN1c1ncccc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C19H19ClN6O3S/c1-12-10-28-8-7-26(12)16-15(3-2-6-21-16)17(27)23-18-24-25-19(30-18)29-11-14-5-4-13(20)9-22-14/h2-6,9,12H,7-8,10-11H2,1H3,(H,23,24,27)	XOKZZHOYHZUMBJ-UHFFFAOYSA-N	96756	(R)-N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-2-(3- methylmorpholino)nicotinamide::US12509454, Compound 22	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96756	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96756&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1099826	164038000							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130414	CS(=O)(=O)N1CCN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)CC1	InChI=1S/C19H20ClN7O4S2/c1-33(29,30)27-9-7-26(8-10-27)16-15(3-2-6-21-16)17(28)23-18-24-25-19(32-18)31-12-14-5-4-13(20)11-22-14/h2-6,11H,7-10,12H2,1H3,(H,23,24,28)	LEAHFOXGSVSOMO-UHFFFAOYSA-N	96757	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-2-(4- (methylsulfonyl)piperazin-1-yl)nicotinamide::US12509454, Compound 23	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96757	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96757&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3176400	164038001							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130415	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1ccnn1-c1ccccc1	InChI=1S/C18H13ClN6O2S/c19-12-6-7-13(20-10-12)11-27-18-24-23-17(28-18)22-16(26)15-8-9-21-25(15)14-4-2-1-3-5-14/h1-10H,11H2,(H,22,23,26)	XIEYXSIBFRNHMF-UHFFFAOYSA-N	96758	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-1-phenyl-1H-pyrazole-5- carboxamide::US12509454, Compound 24	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96758	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96758&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			91899617	164038002							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130416	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cnnn1-c1ccccc1	InChI=1S/C17H12ClN7O2S/c18-11-6-7-12(19-8-11)10-27-17-23-22-16(28-17)21-15(26)14-9-20-24-25(14)13-4-2-1-3-5-13/h1-9H,10H2,(H,21,22,26)	KEAPDCBYMWVIRB-UHFFFAOYSA-N	96759	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-1-phenyl-1H-1,2,3-triazole-5- carboxamide::US12509454, Compound 25	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96759	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96759&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			24746876	164038003							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130417	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cncn1-c1ccccc1Cl	InChI=1S/C18H12Cl2N6O2S/c19-11-5-6-12(22-7-11)9-28-18-25-24-17(29-18)23-16(27)15-8-21-10-26(15)14-4-2-1-3-13(14)20/h1-8,10H,9H2,(H,23,24,27)	OWVQOROPQWDZPP-UHFFFAOYSA-N	96760	1-(2-chlorophenyl)-N-(5-((5-chloropyridin-2- yl)methoxy)-1,3,4-thiadiazol-2-yl)-1H- imidazole-5-carboxamide::US12509454, Compound 26	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96760	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96760&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2989364	164038004							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130418	O=C1CN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)CCN1	InChI=1S/C19H17ClN6O3S/c20-13-5-3-12(4-6-13)11-29-19-25-24-18(30-19)23-17(28)14-2-1-7-22-16(14)26-9-8-21-15(27)10-26/h1-7H,8-11H2,(H,21,27)(H,23,24,28)	GCZXKEKZSJWYFU-UHFFFAOYSA-N	96761	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(3-oxopiperazin-1-yl)nicotinamide-6-d::US12509454, Compound 27	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96761	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96761&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3176405	164038005							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130419	CN(C)C(=O)N1CCN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)CC1	InChI=1S/C22H24ClN7O3S/c1-28(2)22(32)30-12-10-29(11-13-30)18-17(4-3-9-24-18)19(31)25-20-26-27-21(34-20)33-14-15-5-7-16(23)8-6-15/h3-9H,10-14H2,1-2H3,(H,25,26,31)	MLKCBKJVFVNFLI-UHFFFAOYSA-N	96762	4-(3-((5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)carbamoyl)pyridin-2-yl)-N,N- dimethylpiperazine-1-carboxamide::US12509454, Compound 28	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96762	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96762&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			668799	164038006							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130420	CC(C)(O)C#Cc1ccc(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c(N2CCOCC2)n1	InChI=1S/C24H24ClN5O4S/c1-24(2,32)10-9-18-7-8-19(20(26-18)30-11-13-33-14-12-30)21(31)27-22-28-29-23(35-22)34-15-16-3-5-17(25)6-4-16/h3-8,32H,11-15H2,1-2H3,(H,27,28,31)	XAGMOLVJZZZSMZ-UHFFFAOYSA-N	96763	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-(3-hydroxy-3-methylbut-1-yn-1-yl)-2- morpholinonicotinamide::US12509454, Compound 29	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96763	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96763&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2163776	164038007							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130421	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCOC2(CC2)C1	InChI=1S/C21H20ClN5O3S/c22-15-5-3-14(4-6-15)12-29-20-26-25-19(31-20)24-18(28)16-2-1-9-23-17(16)27-10-11-30-21(13-27)7-8-21/h1-6,9H,7-8,10-13H2,(H,24,25,28)	BTUIODUBHYITOU-UHFFFAOYSA-N	96764	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(4-oxa-7-azaspiro[2.5]octan-7- yl)nicotinamide::US12509454, Compound 30	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96764	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96764&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3578707	164038008							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130422	COc1ccc(-n2cncc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c(OC)c1	InChI=1S/C21H18ClN5O4S/c1-29-15-7-8-16(18(9-15)30-2)27-12-23-10-17(27)19(28)24-20-25-26-21(32-20)31-11-13-3-5-14(22)6-4-13/h3-10,12H,11H2,1-2H3,(H,24,25,28)	NDNYYKFGVBOXNF-UHFFFAOYSA-N	96765	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(2,4-dimethoxyphenyl)-1H-imidazole- 5-carboxamide::US12509454, Compound 31	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96765	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96765&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2053862	164038009							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130423	N#Cc1ccc(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)c(N2CCOCC2)n1	InChI=1S/C19H16ClN7O3S/c20-12-1-2-14(22-10-12)11-30-19-26-25-18(31-19)24-17(28)15-4-3-13(9-21)23-16(15)27-5-7-29-8-6-27/h1-4,10H,5-8,11H2,(H,24,25,28)	YKFPVRPCQNMECC-UHFFFAOYSA-N	96766	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-6-cyano-2- morpholinonicotinamide::US12509454, Compound 32	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96766	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96766&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6484119	164038010							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130424	N#Cc1cnc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)c1	InChI=1S/C19H16ClN7O3S/c20-13-1-2-14(22-10-13)11-30-19-26-25-18(31-19)24-17(28)15-7-12(8-21)9-23-16(15)27-3-5-29-6-4-27/h1-2,7,9-10H,3-6,11H2,(H,24,25,28)	UVENHAYPBJIIJL-UHFFFAOYSA-N	96767	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-5-cyano-2- morpholinonicotinamide::US12509454, Compound 33	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96767	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96767&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2870943	164038011							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130425	COc1cc(COc2nnc(NC(=O)c3cccnc3N3CCOCC3)s2)ccc1Cl	InChI=1S/C20H20ClN5O4S/c1-28-16-11-13(4-5-15(16)21)12-30-20-25-24-19(31-20)23-18(27)14-3-2-6-22-17(14)26-7-9-29-10-8-26/h2-6,11H,7-10,12H2,1H3,(H,23,24,27)	HRHYZHIMHWKDQR-UHFFFAOYSA-N	96768	N-(5-((4-chloro-3-methoxybenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-morpholinonicotinamide::US12509454, Compound 34	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96768	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96768&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			5331221	164038012							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130426	N#Cc1cc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C20H17ClN6O3S/c21-14-3-1-13(2-4-14)12-30-20-26-25-19(31-20)24-18(28)16-11-23-15(10-22)9-17(16)27-5-7-29-8-6-27/h1-4,9,11H,5-8,12H2,(H,24,25,28)	QANVSTQNQUYHMD-UHFFFAOYSA-N	96769	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-cyano-4-morpholinonicotinamide::US12509454, Compound 35	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96769	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96769&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3881447	164038013							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130427	COc1cc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C19H19ClN6O4S/c1-28-16-8-15(26-4-6-29-7-5-26)14(10-22-16)17(27)23-18-24-25-19(31-18)30-11-13-3-2-12(20)9-21-13/h2-3,8-10H,4-7,11H2,1H3,(H,23,24,27)	DWZCZWITSOBFPQ-UHFFFAOYSA-N	96770	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-6-methoxy-4- morpholinonicotinamide::US12509454, Compound 36	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96770	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96770&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			4851500	164038014							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130428	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cccnc1N1CCS(=O)(=O)CC1	InChI=1S/C18H17ClN6O4S2/c19-12-3-4-13(21-10-12)11-29-18-24-23-17(30-18)22-16(26)14-2-1-5-20-15(14)25-6-8-31(27,28)9-7-25/h1-5,10H,6-9,11H2,(H,22,23,26)	GBOPEDDWSLGWAX-UHFFFAOYSA-N	96771	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-2-(1,1- dioxidothiomorpholino)nicotinamide::US12509454, Compound 37	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96771	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96771&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			4792422	164038015							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130429	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cncn1-c1ccccn1	InChI=1S/C17H12ClN7O2S/c18-11-4-5-12(21-7-11)9-27-17-24-23-16(28-17)22-15(26)13-8-19-10-25(13)14-3-1-2-6-20-14/h1-8,10H,9H2,(H,22,23,26)	WAIHZDJLIGUSKK-UHFFFAOYSA-N	96772	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-1-(pyridin-2-yl)-1H- imidazole-5-carboxamide::US12509454, Compound 38	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96772	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96772&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16825568	164038016							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130430	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cccnc1N1CCC(F)(F)CC1	InChI=1S/C19H17ClF2N6O2S/c20-12-3-4-13(24-10-12)11-30-18-27-26-17(31-18)25-16(29)14-2-1-7-23-15(14)28-8-5-19(21,22)6-9-28/h1-4,7,10H,5-6,8-9,11H2,(H,25,26,29)	LFLQZZYLXOHKFM-UHFFFAOYSA-N	96773	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-2-(4,4-difluoropiperidin-1- yl)nicotinamide::US12509454, Compound 39	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96773	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96773&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			4239634	164038017							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130431	O=C(Nc1nnc(OCc2ccc(Br)cc2)s1)c1cccnc1N1CCOCC1	InChI=1S/C19H18BrN5O3S/c20-14-5-3-13(4-6-14)12-28-19-24-23-18(29-19)22-17(26)15-2-1-7-21-16(15)25-8-10-27-11-9-25/h1-7H,8-12H2,(H,22,23,26)	YUGXFWBJOGQFSO-UHFFFAOYSA-N	96774	N-(5-((4-bromobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-morpholinonicotinamide::US12509454, Compound 40	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96774	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96774&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			17390528	164038018							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130432	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1c[nH]c(=O)cc1N1CCOCC1	InChI=1S/C19H18ClN5O4S/c20-13-3-1-12(2-4-13)11-29-19-24-23-18(30-19)22-17(27)14-10-21-16(26)9-15(14)25-5-7-28-8-6-25/h1-4,9-10H,5-8,11H2,(H,21,26)(H,22,23,27)	RKOBEIIMNGEAOJ-UHFFFAOYSA-N	96775	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-4-morpholino-6-oxo-1,6- dihydropyridirin-3-carboxamide or its tautomer N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-hydroxy-4-morpholinonicotinamide::US12509454, Compound 41	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96775	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96775&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2411489	164038019							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130433	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cncn1-c1ccccc1Cl	InChI=1S/C19H13Cl2N5O2S/c20-13-7-5-12(6-8-13)10-28-19-25-24-18(29-19)23-17(27)16-9-22-11-26(16)15-4-2-1-3-14(15)21/h1-9,11H,10H2,(H,23,24,27)	KWZROLKBPIJFOT-UHFFFAOYSA-N	96776	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(2-chlorophenyl)-1H-imidazole-5- carboxamide::US12509454, Compound 42	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96776	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96776&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			5931360	164038020							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130434	N#Cc1ccccc1-n1cncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H13ClN6O2S/c21-15-7-5-13(6-8-15)11-29-20-26-25-19(30-20)24-18(28)17-10-23-12-27(17)16-4-2-1-3-14(16)9-22/h1-8,10,12H,11H2,(H,24,25,28)	JZEHMEYGNXDWBR-UHFFFAOYSA-N	96777	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(2-cyanophenyl)-1H-imidazole-5- carboxamide::US12509454, Compound 43	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96777	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96777&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			763210	164038021							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130435	N#Cc1ccc(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c(N2CCOC3(CC3)C2)n1	InChI=1S/C22H19ClN6O3S/c23-15-3-1-14(2-4-15)12-31-21-28-27-20(33-21)26-19(30)17-6-5-16(11-24)25-18(17)29-9-10-32-22(13-29)7-8-22/h1-6H,7-10,12-13H2,(H,26,27,30)	ONKXTEJVZPJORV-UHFFFAOYSA-N	96778	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-cyano-2-(4-oxa-7-azaspiro[2.5]octan- 7-yl)nicotinamide::US12509454, Compound 44	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96778	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96778&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			4851071	164038022							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130436	CN1CCN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)CC1=O	InChI=1S/C20H19ClN6O3S/c1-26-9-10-27(11-16(26)28)17-15(3-2-8-22-17)18(29)23-19-24-25-20(31-19)30-12-13-4-6-14(21)7-5-13/h2-8H,9-12H2,1H3,(H,23,24,29)	JGXQBBPQWXGZFJ-UHFFFAOYSA-N	96779	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(4-methyl-3-oxopiperazin-1- yl)nicotinamide::US12509454, Compound 45	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96779	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96779&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6619424	164038023							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130437	CC1CN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)CC(=O)N1	InChI=1S/C20H19ClN6O3S/c1-12-9-27(10-16(28)23-12)17-15(3-2-8-22-17)18(29)24-19-25-26-20(31-19)30-11-13-4-6-14(21)7-5-13/h2-8,12H,9-11H2,1H3,(H,23,28)(H,24,25,29)	NEVOLNHUEAXYMF-UHFFFAOYSA-N	96780	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(3-methyl-5-oxopiperazin-1- yl)nicotinamide::US12509454, Compound 46	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96780	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96780&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16007794	164038024							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130438	O=C(Nc1nnc(OCc2ccc(C3CC3)cc2)s1)c1cccnc1N1CCOCC1	InChI=1S/C22H23N5O3S/c28-20(18-2-1-9-23-19(18)27-10-12-29-13-11-27)24-21-25-26-22(31-21)30-14-15-3-5-16(6-4-15)17-7-8-17/h1-6,9,17H,7-8,10-14H2,(H,24,25,28)	MBDMDQBLAKLKLV-UHFFFAOYSA-N	96781	N-(5-((4-cyclopropylbenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-morpholinonicotinamide::US12509454, Compound 47	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96781	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96781&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			24791545	164038025							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130439	O=CNc1cc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C20H19ClN6O4S/c21-14-3-1-13(2-4-14)11-31-20-26-25-19(32-20)24-18(29)15-10-22-17(23-12-28)9-16(15)27-5-7-30-8-6-27/h1-4,9-10,12H,5-8,11H2,(H,22,23,28)(H,24,25,29)	ORVLWRBVUSOOHR-UHFFFAOYSA-N	96782	N5-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-4-morpholinopyridine-2,5- dicarboxamide::US12509454, Compound 48	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96782	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96782&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			22510249	164038026							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130440	COc1cccc(-n2cncc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c1	InChI=1S/C20H16ClN5O3S/c1-28-16-4-2-3-15(9-16)26-12-22-10-17(26)18(27)23-19-24-25-20(30-19)29-11-13-5-7-14(21)8-6-13/h2-10,12H,11H2,1H3,(H,23,24,27)	KSYSLPSCFFEOFA-UHFFFAOYSA-N	96783	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(3-methoxyphenyl)-1H-imidazole-5- carboxamide::US12509454, Compound 49	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96783	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96783&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			5654139	164038027							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130441	COc1ccccc1-n1cncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H16ClN5O3S/c1-28-17-5-3-2-4-15(17)26-12-22-10-16(26)18(27)23-19-24-25-20(30-19)29-11-13-6-8-14(21)9-7-13/h2-10,12H,11H2,1H3,(H,23,24,27)	KALGNVXOMCCDAT-UHFFFAOYSA-N	96784	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(2-methoxyphenyl)-1H-imidazole-5- carboxamide::US12509454, Compound 50	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96784	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96784&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			20878831	164038028							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130442	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cccnc1-c1ccccc1Cl	InChI=1S/C20H13Cl2N5O2S/c21-12-7-8-13(24-10-12)11-29-20-27-26-19(30-20)25-18(28)15-5-3-9-23-17(15)14-4-1-2-6-16(14)22/h1-10H,11H2,(H,25,26,28)	NLKXLMNTISRLFI-UHFFFAOYSA-N	96785	2-(2-chlorophenyl)-N-(5-((5-chloropyridin-2- yl)methoxy)-1,3,4-thiadiazol-2- yl)nicotinamide::US12509454, Compound 51	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96785	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96785&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			24793216	164038029							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130443	CC1C(=O)NCCN1c1ncccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H19ClN6O3S/c1-12-17(28)23-9-10-27(12)16-15(3-2-8-22-16)18(29)24-19-25-26-20(31-19)30-11-13-4-6-14(21)7-5-13/h2-8,12H,9-11H2,1H3,(H,23,28)(H,24,25,29)	QXCPCTCMRUZCTJ-UHFFFAOYSA-N	96786	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(2-methyl-3-oxopiperazin-1- yl)nicotinamide::US12509454, Compound 52	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96786	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96786&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			20919854	164038030							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130444	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1C1=CCOCC1	InChI=1S/C20H17ClN4O3S/c21-15-5-3-13(4-6-15)12-28-20-25-24-19(29-20)23-18(26)16-2-1-9-22-17(16)14-7-10-27-11-8-14/h1-7,9H,8,10-12H2,(H,23,24,26)	YTMFILVAOQLXDC-UHFFFAOYSA-N	96787	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(3,6-dihydro-2H-pyran-4- yl)nicotinamide::US12509454, Compound 53	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96787	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96787&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			20876730	164038031							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130445	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1C1CCOCC1	InChI=1S/C20H19ClN4O3S/c21-15-5-3-13(4-6-15)12-28-20-25-24-19(29-20)23-18(26)16-2-1-9-22-17(16)14-7-10-27-11-8-14/h1-6,9,14H,7-8,10-12H2,(H,23,24,26)	VEARPWMVDJCZRZ-UHFFFAOYSA-N	96788	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(tetrahydro-2H-pyran-4- yl)nicotinamide::US12509454, Compound 54	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96788	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96788&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16018447	164038032							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130446	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cncn1C1CCOCC1	InChI=1S/C18H18ClN5O3S/c19-13-3-1-12(2-4-13)10-27-18-23-22-17(28-18)21-16(25)15-9-20-11-24(15)14-5-7-26-8-6-14/h1-4,9,11,14H,5-8,10H2,(H,21,22,25)	QYAWGPYOGPMONT-UHFFFAOYSA-N	96789	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H- imidazole-5-carboxamide::US12509454, Compound 55	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96789	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96789&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			24816983	164038033							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130447	O=C(Nc1nnc(OCc2ccc(C3COC3)cc2)s1)c1cccnc1N1CCOCC1	InChI=1S/C22H23N5O4S/c28-20(18-2-1-7-23-19(18)27-8-10-29-11-9-27)24-21-25-26-22(32-21)31-12-15-3-5-16(6-4-15)17-13-30-14-17/h1-7,17H,8-14H2,(H,24,25,28)	JCXOBAUYSXLVDS-UHFFFAOYSA-N	96790	2-morpholino-N-(5-((4-(oxetan-3- yl)benzyl)oxy)-1,3,4-thiadiazol-2- yl)nicotinamide-6-d::US12509454, Compound 56	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96790	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96790&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			17262955	164038034							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130448	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCN2C(=O)CCC2C1	InChI=1S/C22H21ClN6O3S/c23-15-5-3-14(4-6-15)13-32-22-27-26-21(33-22)25-20(31)17-2-1-9-24-19(17)28-10-11-29-16(12-28)7-8-18(29)30/h1-6,9,16H,7-8,10-13H2,(H,25,26,31)	YUJNOXPXRKGLPW-UHFFFAOYSA-N	96791	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(6-oxohexahydropyrrolo[1,2- a]pyrazin-2(1H)-yl-8a-d)nicotinamide::US12509454, Compound 57	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96791	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96791&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3869589	164038035							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130449	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccc(Br)nc1N1CCOCC1	InChI=1S/C19H17BrClN5O3S/c20-15-6-5-14(16(22-15)26-7-9-28-10-8-26)17(27)23-18-24-25-19(30-18)29-11-12-1-3-13(21)4-2-12/h1-6H,7-11H2,(H,23,24,27)	HWLMWTMZZHQELB-UHFFFAOYSA-N	96792	6-bromo-N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-morpholinonicotinamide::US12509454, Compound 58	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96792	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96792&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			9631625	164038036							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130450	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1N1CCOCC1	InChI=1S/C19H18ClN5O3S/c20-14-3-1-13(2-4-14)12-28-19-24-23-18(29-19)22-17(26)15-5-6-21-11-16(15)25-7-9-27-10-8-25/h1-6,11H,7-10,12H2,(H,22,23,26)	KXGHPYACTZNCBJ-UHFFFAOYSA-N	96793	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-3-morpholinoisonicotinamide::US12509454, Compound 59	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96793	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96793&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			65614	164038037					C06049		1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130451	CC1CNC(=O)CN1c1ncccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H19ClN6O3S/c1-12-9-23-16(28)10-27(12)17-15(3-2-8-22-17)18(29)24-19-25-26-20(31-19)30-11-13-4-6-14(21)7-5-13/h2-8,12H,9-11H2,1H3,(H,23,28)(H,24,25,29)	RJHXQSHUHGFOOY-UHFFFAOYSA-N	96794	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(2-methyl-5-oxopiperazin-1- yl)nicotinamide::US12509454, Compound 60	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96794	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96794&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			7192025	164038038							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130452	O=C1CCN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)CCN1	InChI=1S/C20H19ClN6O3S/c21-14-5-3-13(4-6-14)12-30-20-26-25-19(31-20)24-18(29)15-2-1-8-23-17(15)27-10-7-16(28)22-9-11-27/h1-6,8H,7,9-12H2,(H,22,28)(H,24,25,29)	CKYHGSXOCBNGBC-UHFFFAOYSA-N	96795	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(5-oxo-1,4-diazepan-1- yl)nicotinamide::US12509454, Compound 61	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96795	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96795&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			7386906	164038039							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130453	COc1ccccc1-n1cncc1C(=O)Nc1nnc(OCc2ccc(C3CC3)cc2)s1	InChI=1S/C23H21N5O3S/c1-30-20-5-3-2-4-18(20)28-14-24-12-19(28)21(29)25-22-26-27-23(32-22)31-13-15-6-8-16(9-7-15)17-10-11-17/h2-9,12,14,17H,10-11,13H2,1H3,(H,25,26,29)	VRDKTEVHZTUCBI-UHFFFAOYSA-N	96796	N-(5-((4-cyclopropylbenzyl)oxy)-1,3,4- thiadiazol-2-yl)-1-(2-methoxyphenyl)-1H- imidazole-5-carboxamide::US12509454, Compound 62	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96796	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96796&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			7423413	164038040							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130454	O=C1CN(c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)CCCN1	InChI=1S/C20H19ClN6O3S/c21-14-6-4-13(5-7-14)12-30-20-26-25-19(31-20)24-18(29)15-3-1-8-23-17(15)27-10-2-9-22-16(28)11-27/h1,3-8H,2,9-12H2,(H,22,28)(H,24,25,29)	RYBKACUFCFMSQY-UHFFFAOYSA-N	96797	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(3-oxo-1,4-diazepan-1- yl)nicotinamide::US12509454, Compound 63	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96797	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96797&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			7423412	164038041							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130455	CNC(=O)c1cc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C21H21ClN6O4S/c1-23-19(30)16-10-17(28-6-8-31-9-7-28)15(11-24-16)18(29)25-20-26-27-21(33-20)32-12-13-2-4-14(22)5-3-13/h2-5,10-11H,6-9,12H2,1H3,(H,23,30)(H,25,26,29)	UMLSUMKRKNMAFM-UHFFFAOYSA-N	96798	N5-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-N2-methyl-4-morpholinopyridine-2,5- dicarboxamide::US12509454, Compound 64	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96798	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96798&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16812389	164038042							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130456	O=C(Nc1nnc(OCc2ccc(-c3ncco3)cc2)s1)c1cccnc1N1CCOCC1	InChI=1S/C22H20N6O4S/c29-19(17-2-1-7-23-18(17)28-9-12-30-13-10-28)25-21-26-27-22(33-21)32-14-15-3-5-16(6-4-15)20-24-8-11-31-20/h1-8,11H,9-10,12-14H2,(H,25,26,29)	CHCANQBOFRPARS-UHFFFAOYSA-N	96799	2-morpholino-N-(5-((4-(oxazol-2- yl)benzyl)oxy)-1,3,4-thiadiazol-2- yl)nicotinamide::US12509454, Compound 65	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96799	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96799&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			18580037	164038043							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130457	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCOc2ccccc21	InChI=1S/C23H18ClN5O3S/c24-16-9-7-15(8-10-16)14-32-23-28-27-22(33-23)26-21(30)17-4-3-11-25-20(17)29-12-13-31-19-6-2-1-5-18(19)29/h1-11H,12-14H2,(H,26,27,30)	LDIVVSFQVAJFPW-UHFFFAOYSA-N	96800	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(2,3-dihydro-4H-benzo[b][1,4]oxazin- 4-yl)nicotinamide::US12509454, Compound 66	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96800	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96800&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			7607298	164038044							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130458	COc1ccccc1-c1ncccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C22H17ClN4O3S/c1-29-18-7-3-2-5-16(18)19-17(6-4-12-24-19)20(28)25-21-26-27-22(31-21)30-13-14-8-10-15(23)11-9-14/h2-12H,13H2,1H3,(H,25,26,28)	GLQCOZRJPPOMNF-UHFFFAOYSA-N	96802	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(2-methoxyphenyl)nicotinamide::US12509454, Compound 67	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96802	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96802&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			10220536	164038046							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130459	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCN(CCO)C(=O)C1	InChI=1S/C21H21ClN6O4S/c22-15-5-3-14(4-6-15)13-32-21-26-25-20(33-21)24-19(31)16-2-1-7-23-18(16)28-9-8-27(10-11-29)17(30)12-28/h1-7,29H,8-13H2,(H,24,25,31)	UIHOLSSWTXRHKZ-UHFFFAOYSA-N	96803	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-(4-(2-hydroxyethyl)-3-oxopiperazin- 1-yl)nicotinamide::US12509454, Compound 68	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96803	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96803&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2593765	164038047							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130460	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCN2C(=O)CC[C@H]2C1	InChI=1S/C22H21ClN6O3S/c23-15-5-3-14(4-6-15)13-32-22-27-26-21(33-22)25-20(31)17-2-1-9-24-19(17)28-10-11-29-16(12-28)7-8-18(29)30/h1-6,9,16H,7-8,10-13H2,(H,25,26,31)	YUJNOXPXRKGLPW-UHFFFAOYSA-N	96804	(S)-N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-(6- oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl- 8a-d)nicotinamide::US12509454, Compound 69	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96804	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96804&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			8661334	164038048							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130461	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1N1CCN2C(=O)CC[C@@H]2C1	InChI=1S/C22H21ClN6O3S/c23-15-5-3-14(4-6-15)13-32-22-27-26-21(33-22)25-20(31)17-2-1-9-24-19(17)28-10-11-29-16(12-28)7-8-18(29)30/h1-6,9,16H,7-8,10-13H2,(H,25,26,31)	YUJNOXPXRKGLPW-UHFFFAOYSA-N	96805	(R)-N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-(6- oxohexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl- 8a-d)nicotinamide::US12509454, Compound 70	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96805	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96805&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			4785037	164038049							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130462	N#Cc1ccc(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c(-c2ccccc2OC)n1	InChI=1S/C23H16ClN5O3S/c1-31-19-5-3-2-4-17(19)20-18(11-10-16(12-25)26-20)21(30)27-22-28-29-23(33-22)32-13-14-6-8-15(24)9-7-14/h2-11H,13H2,1H3,(H,27,28,30)	GXJUBKGEATXJHC-UHFFFAOYSA-N	96806	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-cyano-2-(2- methoxyphenyl)nicotinamide::US12509454, Compound 71	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96806	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96806&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3678812	164038050							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130463	N#Cc1ccc(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c(N2CCOCC2)c1	InChI=1S/C21H18ClN5O3S/c22-16-4-1-14(2-5-16)13-30-21-26-25-20(31-21)24-19(28)17-6-3-15(12-23)11-18(17)27-7-9-29-10-8-27/h1-6,11H,7-10,13H2,(H,24,25,28)	XNEBOOPHLLXMDG-UHFFFAOYSA-N	96807	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-4-cyano-2-morpholinobenzamide::US12509454, Compound 72	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96807	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96807&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16330350	164038051							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130464	CN(C)C(=O)c1cc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C22H23ClN6O4S/c1-28(2)20(31)17-11-18(29-7-9-32-10-8-29)16(12-24-17)19(30)25-21-26-27-22(34-21)33-13-14-3-5-15(23)6-4-14/h3-6,11-12H,7-10,13H2,1-2H3,(H,25,26,30)	GDUFJKJCAWSVEK-UHFFFAOYSA-N	96808	N5-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-N2,N2-dimethyl-4-morpholinopyridine- 2,5-dicarboxamide::US12509454, Compound 73	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96808	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96808&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16326306	164038052							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130465	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1-c1cc[nH]c(=O)c1	InChI=1S/C20H14ClN5O3S/c21-14-5-3-12(4-6-14)11-29-20-26-25-19(30-20)24-18(28)15-2-1-8-23-17(15)13-7-9-22-16(27)10-13/h1-10H,11H2,(H,22,27)(H,24,25,28)	UDYDFIIMOWMWCE-UHFFFAOYSA-N	96809	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2'-oxo-1',2'-dihydro-[2,4'-bipyridine]-3- carboxamide or its tautomer N-(5-((4- chlorobenzyl)oxy)-1,3,4-thiadiazol-2-yl)-2'- hydroxy-[2,4'-bipyridine]-3-carboxamide::US12509454, Compound 74	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96809	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96809&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3956566	164038053							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130466	COc1cc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C20H20ClN5O4S/c1-28-17-10-16(26-6-8-29-9-7-26)15(11-22-17)18(27)23-19-24-25-20(31-19)30-12-13-2-4-14(21)5-3-13/h2-5,10-11H,6-9,12H2,1H3,(H,23,24,27)	GDAYFTJASDHPGM-UHFFFAOYSA-N	96810	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-methoxy-4-morpholinonicotinamide::US12509454, Compound 75	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96810	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96810&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			718645	164038054							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130467	N#Cc1ccc(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c(N2CCNC(=O)C2)n1	InChI=1S/C20H16ClN7O3S/c21-13-3-1-12(2-4-13)11-31-20-27-26-19(32-20)25-18(30)15-6-5-14(9-22)24-17(15)28-8-7-23-16(29)10-28/h1-6H,7-8,10-11H2,(H,23,29)(H,25,26,30)	UWXUWYBZYMAJLY-UHFFFAOYSA-N	96811	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-cyano-2-(3-oxopiperazin-1- yl)nicotinamide::US12509454, Compound 76	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96811	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96811&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			42601283	164038055							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130468	COc1ccccc1-c1ccncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C22H17ClN4O3S/c1-29-19-5-3-2-4-17(19)16-10-11-24-12-18(16)20(28)25-21-26-27-22(31-21)30-13-14-6-8-15(23)9-7-14/h2-12H,13H2,1H3,(H,25,26,28)	NKBJFGOHTSTLNB-UHFFFAOYSA-N	96812	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-4-(2-methoxyphenyl)nicotinamide::US12509454, Compound 77	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96812	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96812&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			4788237	164038056							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130469	CC(=O)Nc1cc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C21H21ClN6O4S/c1-13(29)24-18-10-17(28-6-8-31-9-7-28)16(11-23-18)19(30)25-20-26-27-21(33-20)32-12-14-2-4-15(22)5-3-14/h2-5,10-11H,6-9,12H2,1H3,(H,23,24,29)(H,25,26,30)	PZLNPXATWSDVJR-UHFFFAOYSA-N	96813	6-acetamido-N-(5-((4-chlorobenzyl)oxy)- 1,3,4-thiadiazol-2-yl)-4- morpholinonicotinamide::US12509454, Compound 78	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96813	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96813&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16275304	164038057							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130470	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1-c1ccc(=O)[nH]c1	InChI=1S/C20H14ClN5O3S/c21-14-6-3-12(4-7-14)11-29-20-26-25-19(30-20)24-18(28)15-2-1-9-22-17(15)13-5-8-16(27)23-10-13/h1-10H,11H2,(H,23,27)(H,24,25,28)	WIFLFFWCFHSNJR-UHFFFAOYSA-N	96814	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6'-oxo-1',6'-dihydro-[2,3'-bipyridine]-3- carboxamide or its tautomer N-(5-((4- chlorobenzyl)oxy)-1,3,4-thiadiazol-2-yl)-6'- hydroxy-[2,3'-bipyridine]-3-carboxamide::US12509454, Compound 79	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96814	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96814&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2602001	164038058							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130471	Cn1cc(-c2ncccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)ccc1=O	InChI=1S/C21H16ClN5O3S/c1-27-11-14(6-9-17(27)28)18-16(3-2-10-23-18)19(29)24-20-25-26-21(31-20)30-12-13-4-7-15(22)8-5-13/h2-11H,12H2,1H3,(H,24,25,29)	RJERBARVJYKAAA-UHFFFAOYSA-N	96815	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1'-methyl-6'-oxo-1',6'-dihydro-[2,3'- bipyridine]-3-carboxamido::US12509454, Compound 80	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96815	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96815&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			9113346	164038059							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130472	COc1ccccc1-c1cnc(F)cc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C22H16ClFN4O3S/c1-30-18-5-3-2-4-15(18)17-11-25-19(24)10-16(17)20(29)26-21-27-28-22(32-21)31-12-13-6-8-14(23)9-7-13/h2-11H,12H2,1H3,(H,26,27,29)	MCZDAFBUMCQYOE-UHFFFAOYSA-N	96816	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-fluoro-5-(2-methoxyphenyl)- isonicotinamide::US12509454, Compound 81	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96816	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96816&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16292840	164038060							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130473	COc1ccccc1-n1nncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C19H15ClN6O3S/c1-28-16-5-3-2-4-14(16)26-15(10-21-25-26)17(27)22-18-23-24-19(30-18)29-11-12-6-8-13(20)9-7-12/h2-10H,11H2,1H3,(H,22,23,27)	OLXMCYHTANIKSA-UHFFFAOYSA-N	96817	N-(5-((4-fluorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(2-methoxyphenyl)-1H-1,2,3-triazole- 5-carboxamide::US12509454, Compound 82	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96817	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96817&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			653784	164038061							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130474	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cnccc1N1CCN(CCN2CCOCC2)C(=O)C1	InChI=1S/C25H28ClN7O4S/c26-19-3-1-18(2-4-19)17-37-25-30-29-24(38-25)28-23(35)20-15-27-6-5-21(20)33-10-9-32(22(34)16-33)8-7-31-11-13-36-14-12-31/h1-6,15H,7-14,16-17H2,(H,28,29,35)	XNQODJVELLMXCR-UHFFFAOYSA-N	96818	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-4-(4-(2-morpholinoethyl)-3- oxopiperazin-1-yl)nicotinamide::US12509454, Compound 83	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96818	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96818&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			235976	164038062							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130475	O=C(O)c1cc(N2CCOCC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C20H18ClN5O5S/c21-13-3-1-12(2-4-13)11-31-20-25-24-19(32-20)23-17(27)14-10-22-15(18(28)29)9-16(14)26-5-7-30-8-6-26/h1-4,9-10H,5-8,11H2,(H,28,29)(H,23,24,27)	HLXTTYRTKHJDCZ-UHFFFAOYSA-N	96819	5-((5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)carbamoyl)-4-morpholinopicolinic acid::US12509454, Compound 84	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96819	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96819&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1814746	164038063							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130476	N#Cc1ccc(C(=O)Nc2nnc(OCc3ccc(Br)cc3)s2)c(N2CCOC3(CC3)C2)n1	InChI=1S/C22H19BrN6O3S/c23-15-3-1-14(2-4-15)12-31-21-28-27-20(33-21)26-19(30)17-6-5-16(11-24)25-18(17)29-9-10-32-22(13-29)7-8-22/h1-6H,7-10,12-13H2,(H,26,27,30)	JMIAHCWGRPEMTM-UHFFFAOYSA-N	96820	N-(5-((4-bromobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-cyano-2-(4-oxa-7-azaspiro[2.5]octan- 7-yl)nicotinamide::US12509454, Compound 85	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96820	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96820&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			9550740	164038064							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130477	COc1ccccc1-n1cncc1C(=O)Nc1nnc(OCc2ccc(Br)cc2)s1	InChI=1S/C20H16BrN5O3S/c1-28-17-5-3-2-4-15(17)26-12-22-10-16(26)18(27)23-19-24-25-20(30-19)29-11-13-6-8-14(21)9-7-13/h2-10,12H,11H2,1H3,(H,23,24,27)	IEMLGLAKRCEYRL-UHFFFAOYSA-N	96821	N-(5-((4-bromobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-1-(2-methoxyphenyl)-1H-imidazole-5- carboxamide::US12509454, Compound 86	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96821	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96821&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			241049	164038065							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130478	CNC(=O)c1cc(N2CCNC(=O)CC2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C22H22ClN7O4S/c1-24-20(33)16-10-17(30-8-6-18(31)25-7-9-30)15(11-26-16)19(32)27-21-28-29-22(35-21)34-12-13-2-4-14(23)5-3-13/h2-5,10-11H,6-9,12H2,1H3,(H,24,33)(H,25,31)(H,27,28,32)	CXLBJMPRZNHHMP-UHFFFAOYSA-N	96822	N5-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-N2-methyl-4-(5-oxo-1,4-diazepan-1- yl)pyridine-2,5-dicarboxamide::US12509454, Compound 87	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96822	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96822&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			91899618	164038066							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130479	N#Cc1ccc(C(=O)Nc2nnc(OCc3ccc(Br)cc3)s2)c(N2CCNC(=O)C2)n1	InChI=1S/C20H16BrN7O3S/c21-13-3-1-12(2-4-13)11-31-20-27-26-19(32-20)25-18(30)15-6-5-14(9-22)24-17(15)28-8-7-23-16(29)10-28/h1-6H,7-8,10-11H2,(H,23,29)(H,25,26,30)	UNYYQGQUSQQUGE-UHFFFAOYSA-N	96823	N-(5-((4-bromobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-cyano-2-(3-oxopiperazin-1- yl)nicotinamide::US12509454, Compound 88	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96823	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96823&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			384844	164038067							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130480	COc1ccccc1-c1ccncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C21H16ClN5O3S/c1-29-18-5-3-2-4-16(18)15-8-9-23-11-17(15)19(28)25-20-26-27-21(31-20)30-12-14-7-6-13(22)10-24-14/h2-11H,12H2,1H3,(H,25,26,28)	RANBKTIAUXTJIA-UHFFFAOYSA-N	96824	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 89	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96824	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96824&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			11952	164038068							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130481	COc1ccccc1-c1ccncc1C(=O)Nc1nnc(OCC2CC2)s1	InChI=1S/C19H18N4O3S/c1-25-16-5-3-2-4-14(16)13-8-9-20-10-15(13)17(24)21-18-22-23-19(27-18)26-11-12-6-7-12/h2-5,8-10,12H,6-7,11H2,1H3,(H,21,22,24)	IQLVHWGPDDAKJN-UHFFFAOYSA-N	96825	N-(5-(cyclopropylmethoxy)-1,3,4-thiadiazol- 2-yl)-4-(2-methoxyphenyl)nicotinamide::US12509454, Compound 90	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96825	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96825&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			98724	164038069							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130482	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1-c1ccccc1Cl	InChI=1S/C21H14Cl2N4O2S/c22-14-9-7-13(8-10-14)12-29-21-27-26-20(30-21)25-19(28)16-5-3-11-24-18(16)15-4-1-2-6-17(15)23/h1-11H,12H2,(H,25,26,28)	OADCYNLYVPNQHQ-UHFFFAOYSA-N	96826	2-(2-chlorophenyl)-N-[5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl]pyridine-3-carboxamide::US12509454, Compound 91	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96826	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96826&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			72816	164038070							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130483	N#Cc1cc(-c2ccccc2OC)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C23H16ClN5O3S/c1-31-20-5-3-2-4-17(20)18-10-16(11-25)26-12-19(18)21(30)27-22-28-29-23(33-22)32-13-14-6-8-15(24)9-7-14/h2-10,12H,13H2,1H3,(H,27,28,30)	VBZMFMGXAQKXAA-UHFFFAOYSA-N	96827	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-cyano-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 92	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96827	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96827&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6392532	164038071							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130484	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cnccc1-c1ccccc1OC1CC1	InChI=1S/C24H19ClN4O3S/c25-16-7-5-15(6-8-16)14-31-24-29-28-23(33-24)27-22(30)20-13-26-12-11-18(20)19-3-1-2-4-21(19)32-17-9-10-17/h1-8,11-13,17H,9-10,14H2,(H,27,28,30)	MLYKRUNCKXRHPH-UHFFFAOYSA-N	96828	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-4-(2-cyclopropoxyphenyl)nicotinamide::US12509454, Compound 93	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96828	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96828&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6392533	164038072							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130485	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1-c1ccccc1	InChI=1S/C21H15ClN4O2S/c22-16-10-8-14(9-11-16)13-28-21-26-25-20(29-21)24-19(27)17-7-4-12-23-18(17)15-5-2-1-3-6-15/h1-12H,13H2,(H,24,25,27)	XQCLPRMQSOJYIE-UHFFFAOYSA-N	96829	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-2-phenylnicotinamide::US12509454, Compound 94	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96829	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96829&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			46903481	164038073							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130486	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C22H17ClN4O3S/c1-29-19-5-3-2-4-16(19)18-12-24-11-10-17(18)20(28)25-21-26-27-22(31-21)30-13-14-6-8-15(23)9-7-14/h2-12H,13H2,1H3,(H,25,26,28)	ZAEYDSHIXXLWTJ-UHFFFAOYSA-N	715312	US20250026748, Compound 476::US12509454, Compound 95	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=715312	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=715312&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			155342346	513835364							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130487	N#Cc1cc(-c2ccccc2OC)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C22H15ClN6O3S/c1-31-19-5-3-2-4-16(19)17-8-15(9-24)26-11-18(17)20(30)27-21-28-29-22(33-21)32-12-14-7-6-13(23)10-25-14/h2-8,10-11H,12H2,1H3,(H,27,28,30)	OQSPKMOHSTUEOC-UHFFFAOYSA-N	96831	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-6-cyano-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 96	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96831	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96831&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			46942876	164038075							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130488	COc1ccccc1-c1ccncc1C(=O)Nc1nnc(OCc2ccc(Br)cn2)s1	InChI=1S/C21H16BrN5O3S/c1-29-18-5-3-2-4-16(18)15-8-9-23-11-17(15)19(28)25-20-26-27-21(31-20)30-12-14-7-6-13(22)10-24-14/h2-11H,12H2,1H3,(H,25,26,28)	NGHWSKIHMHWOBI-UHFFFAOYSA-N	96832	N-(5-((5-bromopyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 97	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96832	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96832&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3574265	164038076							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130489	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cnc(-c2ncc[nH]2)cc1N1CCOCC1	InChI=1S/C22H20ClN7O3S/c23-15-3-1-14(2-4-15)13-33-22-29-28-21(34-22)27-20(31)16-12-26-17(19-24-5-6-25-19)11-18(16)30-7-9-32-10-8-30/h1-6,11-12H,7-10,13H2,(H,24,25)(H,27,28,31)	JDTMYHWWPSUVLV-UHFFFAOYSA-N	96833	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-(1H-imidazol-2-yl)-4- morpholinonicotinamide::US12509454, Compound 98	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96833	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96833&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			46944160	164038077							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130490	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C21H16ClN5O3S/c1-29-18-5-3-2-4-15(18)17-11-23-9-8-16(17)19(28)25-20-26-27-21(31-20)30-12-14-7-6-13(22)10-24-14/h2-11H,12H2,1H3,(H,25,26,28)	REZMONWROTVQHG-UHFFFAOYSA-N	96834	N-[5-[(5-chloropyridin-2-yl)methoxy]-1,3,4- thiadiazol-2-yl]-3-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 99	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96834	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96834&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			45224887	164038078							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130491	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1ccccc1OC(F)F	InChI=1S/C22H15ClF2N4O3S/c23-14-7-5-13(6-8-14)12-31-22-29-28-21(33-22)27-19(30)16-9-10-26-11-17(16)15-3-1-2-4-18(15)32-20(24)25/h1-11,20H,12H2,(H,27,28,30)	ZIAYSAKFEQKOBM-UHFFFAOYSA-N	96835	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-3-(2- (difluoromethoxy)phenyl)isonicotinamide::US12509454, Compound 100	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96835	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96835&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			49786599	164038079							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130492	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(C3CC3)nc2)s1	InChI=1S/C24H21N5O3S/c1-31-21-5-3-2-4-17(21)19-13-25-11-10-18(19)22(30)27-23-28-29-24(33-23)32-14-15-6-9-20(26-12-15)16-7-8-16/h2-6,9-13,16H,7-8,14H2,1H3,(H,27,28,30)	LZJSBYNDMQUMNZ-UHFFFAOYSA-N	96836	N-[5-[(6-cyclopropylpyridin-3-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-3-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 101	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96836	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96836&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			49792404	164038080					C04080		1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130493	COc1ccccc1-c1cc(CO)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H19ClN4O4S/c1-31-20-5-3-2-4-17(20)18-10-16(12-29)25-11-19(18)21(30)26-22-27-28-23(33-22)32-13-14-6-8-15(24)9-7-14/h2-11,29H,12-13H2,1H3,(H,26,27,30)	QPEJVEFGZAXLRO-UHFFFAOYSA-N	96837	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-(hydroxymethyl)-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 102	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96837	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96837&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			51360628	164038081							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130494	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1cccc2nsnc12	InChI=1S/C21H13ClN6O2S2/c22-13-6-4-12(5-7-13)11-30-21-26-25-20(31-21)24-19(29)15-8-9-23-10-16(15)14-2-1-3-17-18(14)28-32-27-17/h1-10H,11H2,(H,24,25,29)	LYVPJFWOLPZHMF-UHFFFAOYSA-N	96838	3-(benzo[c][1,2.5]thiadiazol-4-yl)-N-(5-((4- chlorobenzyl)oxy)-1,3,4-thiadiazol-2- yl)isonicotinamide::US12509454, Compound 103	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96838	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96838&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			51361119	164038082							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130495	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cnc(CO)cc1-c1ccccc1OC(F)F	InChI=1S/C22H16ClF2N5O4S/c23-12-5-6-13(26-8-12)11-33-22-30-29-21(35-22)28-19(32)17-9-27-14(10-31)7-16(17)15-3-1-2-4-18(15)34-20(24)25/h1-9,20,31H,10-11H2,(H,28,29,32)	WPYCGVXHEADVJT-UHFFFAOYSA-N	96839	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-4-(2- (difluoromethoxy)phenyl)-6- (hydroxymethyl)nicotinamide::US12509454, Compound 104	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96839	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96839&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			51361122	164038083							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130496	COc1ccccc1-c1cc(CC#N)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C24H18ClN5O3S/c1-32-21-5-3-2-4-18(21)19-12-17(10-11-26)27-13-20(19)22(31)28-23-29-30-24(34-23)33-14-15-6-8-16(25)9-7-15/h2-9,12-13H,10,14H2,1H3,(H,28,29,31)	UBXFIYIHXXZLDG-UHFFFAOYSA-N	96840	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-6-(cyanomethyl)-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 105	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96840	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96840&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			51361134	164038084							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130497	COc1ccccc1-c1cnncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C20H15ClN6O3S/c1-29-17-5-3-2-4-14(17)15-9-23-24-10-16(15)18(28)25-19-26-27-20(31-19)30-11-13-7-6-12(21)8-22-13/h2-10H,11H2,1H3,(H,25,26,28)	UNOWSIOSGPXSQJ-UHFFFAOYSA-N	96843	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-5-(2- methoxyphenyl)pyridazine-4-carboxamide::US12509454, Compound 106	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96843	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96843&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53299953	164038087							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130498	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)c3[nH]ncc23)s1	InChI=1S/C23H17ClN6O3S/c1-32-19-5-3-2-4-14(19)17-10-25-9-8-15(17)21(31)27-22-29-30-23(34-22)33-12-13-6-7-18(24)20-16(13)11-26-28-20/h2-11H,12H2,1H3,(H,26,28)(H,27,29,31)	PMXYMWKRFXETIU-UHFFFAOYSA-N	96844	N-(5-((7-chloro-1H-indazol-4-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-3-(2- methoxyphenyl)isonicotinamide::US12509454, Compound 107	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96844	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96844&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53300042	164038088							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130499	N#Cc1ccc(OC(F)F)c(-c2cnccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c1	InChI=1S/C23H14ClF2N5O3S/c24-15-4-1-13(2-5-15)12-33-23-31-30-22(35-23)29-20(32)16-7-8-28-11-18(16)17-9-14(10-27)3-6-19(17)34-21(25)26/h1-9,11,21H,12H2,(H,29,30,32)	RQRDFKXEJAIAPP-UHFFFAOYSA-N	96845	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-3-(5-cyano-2- (difluoromethoxy)phenyl)isonicotinamide::US12509454, Compound 108	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96845	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96845&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53300065	164038089							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130500	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1c(F)cccc1OC(F)F	InChI=1S/C22H14ClF3N4O3S/c23-13-6-4-12(5-7-13)11-32-22-30-29-21(34-22)28-19(31)14-8-9-27-10-15(14)18-16(24)2-1-3-17(18)33-20(25)26/h1-10,20H,11H2,(H,28,29,31)	CCWXXFHYFQZDLY-UHFFFAOYSA-N	96846	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-3-(2-(difluoromethoxy)-6- fluorophenyl)isonicotinamide::US12509454, Compound 109	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96846	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96846&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53300088	164038090							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130501	C[C@H]1COC[C@H](C)N1c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C21H22ClN5O3S/c1-13-10-29-11-14(2)27(13)18-9-23-8-7-17(18)19(28)24-20-25-26-21(31-20)30-12-15-3-5-16(22)6-4-15/h3-9,13-14H,10-12H2,1-2H3,(H,24,25,28)	FJDRHZZGZKCOOJ-UHFFFAOYSA-N	96847	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-3-((3S,5S)-3,5- dimethylmorpholino)isonicotinamide::US12509454, Compound 110	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96847	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96847&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53300195	164038091							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130502	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1cccc2ncoc12	InChI=1S/C22H14ClN5O3S/c23-14-6-4-13(5-7-14)11-30-22-28-27-21(32-22)26-20(29)16-8-9-24-10-17(16)15-2-1-3-18-19(15)31-12-25-18/h1-10,12H,11H2,(H,26,27,29)	DNXYDGCPJMKEPX-UHFFFAOYSA-N	96848	3-(benzo[d]oxazol-7-yl)-N-(5-((4- chlorobenzyl)oxy)-1,3,4-thiadiazol-2- yl)isonicotinamide::US12509454, Compound 111	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96848	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96848&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			50985926	164038092							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130503	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cnncc1-c1ccccc1OC(F)F	InChI=1S/C21H14ClF2N5O3S/c22-13-7-5-12(6-8-13)11-31-21-29-28-20(33-21)27-18(30)16-10-26-25-9-15(16)14-3-1-2-4-17(14)32-19(23)24/h1-10,19H,11H2,(H,27,28,30)	FPYQCMUZOZTCIA-UHFFFAOYSA-N	96849	N-(5-((4-chlorobenzyl)oxy)-1,3,4-thiadiazol- 2-yl)-5-(2- (difluoromethoxy)phenyl)pyridazine-4- carboxamide::US12509454, Compound 112	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96849	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96849&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53382661	164038093							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130504	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C22H18ClN5O3S/c1-13-9-17(16-5-3-4-6-19(16)30-2)18(11-24-13)20(29)26-21-27-28-22(32-21)31-12-15-8-7-14(23)10-25-15/h3-11H,12H2,1-2H3,(H,26,27,29)	HEPWAAYAIWGPLX-UHFFFAOYSA-N	96850	N-(5-((5-chloropyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)-4-(2-methoxyphenyl)-6- methylnicotinamide::US12509454, Compound 113	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96850	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96850&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			674370	164038094							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130505	Cc1cc(-c2ccccc2OC(F)F)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C23H17ClF2N4O3S/c1-13-10-17(16-4-2-3-5-19(16)33-21(25)26)18(11-27-13)20(31)28-22-29-30-23(34-22)32-12-14-6-8-15(24)9-7-14/h2-11,21H,12H2,1H3,(H,28,29,31)	LURWXOLGUKUCTE-UHFFFAOYSA-N	96851	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-4-[2- (difluoromethoxy)phenyl]-6-methylpyridine- 3-carboxamide::US12509454, Compound 114	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96851	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96851&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53383658	164038095							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130506	Cc1cc(-c2ccccc2OC(F)F)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C22H16ClF2N5O3S/c1-12-8-16(15-4-2-3-5-18(15)33-20(24)25)17(10-26-12)19(31)28-21-29-30-22(34-21)32-11-14-7-6-13(23)9-27-14/h2-10,20H,11H2,1H3,(H,28,29,31)	KXOOQSRTFCCPJB-UHFFFAOYSA-N	96852	N-[5-[(5-chloropyridin-2-yl)methoxy]-1,3,4- thiadiazol-2-yl]-4-[2- (difluoromethoxy)phenyl]-6-metbylpyridine- 3-carboxamide::US12509454, Compound 115	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96852	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96852&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53383675	164038096							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130507	COc1ccc(C#N)cc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C24H18ClN5O3S/c1-14-9-18(19-10-16(11-26)5-8-21(19)32-2)20(12-27-14)22(31)28-23-29-30-24(34-23)33-13-15-3-6-17(25)7-4-15/h3-10,12H,13H2,1-2H3,(H,28,29,31)	ACIHVRAYUYCVLP-UHFFFAOYSA-N	96853	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-4-(5-cyano-2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 116	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96853	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96853&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53383840	164038097							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130508	COc1ccc(C#N)cc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C23H17ClN6O3S/c1-13-7-17(18-8-14(9-25)3-6-20(18)32-2)19(11-26-13)21(31)28-22-29-30-23(34-22)33-12-16-5-4-15(24)10-27-16/h3-8,10-11H,12H2,1-2H3,(H,28,29,31)	BCWZTQTXPRAVNE-UHFFFAOYSA-N	96854	N-[5-[(5-chloropyridin-2-yl)methoxy]-1,3,4- thiadiazol-2-yl]-4-(5-cyano-2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 117	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96854	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96854&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53383948	164038098							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130509	Cc1cn[nH]c1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C19H15ClN6O2S/c1-11-8-22-24-16(11)15-9-21-7-6-14(15)17(27)23-18-25-26-19(29-18)28-10-12-2-4-13(20)5-3-12/h2-9H,10H2,1H3,(H,22,24)(H,23,25,27)	MMLDTHHQAMXIDE-UHFFFAOYSA-N	96855	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(4-methyl-1H-pyrazol- 5-yl)isonicotinamide::US12509454, Compound 118	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96855	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96855&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			51049944	164038099							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130510	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1cccc2[nH]ncc12	InChI=1S/C22H15ClN6O2S/c23-14-6-4-13(5-7-14)12-31-22-29-28-21(32-22)26-20(30)16-8-9-24-10-17(16)15-2-1-3-19-18(15)11-25-27-19/h1-11H,12H2,(H,25,27)(H,26,28,30)	FKYBEXLFPDDDEB-UHFFFAOYSA-N	96856	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(1H-indazol-4- yl)isonicotinamide::US12509454, Compound 119	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96856	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96856&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			51049949	164038100							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130511	O=C1COc2c(cccc2-c2cnccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)N1	InChI=1S/C23H16ClN5O4S/c24-14-6-4-13(5-7-14)11-33-23-29-28-22(34-23)27-21(31)16-8-9-25-10-17(16)15-2-1-3-18-20(15)32-12-19(30)26-18/h1-10H,11-12H2,(H,26,30)(H,27,28,31)	SGIPOHKLSUHQTP-UHFFFAOYSA-N	96857	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(3-oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-8-yl)isonicotinamide::US12509454, Compound 120	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96857	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96857&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			51049962	164038101							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130512	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1cccc2c1OC(F)(F)O2	InChI=1S/C22H13ClF2N4O4S/c23-13-6-4-12(5-7-13)11-31-21-29-28-20(34-21)27-19(30)15-8-9-26-10-16(15)14-2-1-3-17-18(14)33-22(24,25)32-17/h1-10H,11H2,(H,27,28,30)	VUQHCYMYCGIJFR-UHFFFAOYSA-N	96858	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(2,2- difluorobenzo[d][1,3]dioxol-4- yl)isonicotinamide::US12509454, Compound 121	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96858	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96858&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361799	164038102							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130513	Cn1cc(-c2ccncc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)ccc1=O	InChI=1S/C21H16ClN5O3S/c1-27-11-14(4-7-18(27)28)16-8-9-23-10-17(16)19(29)24-20-25-26-21(31-20)30-12-13-2-5-15(22)6-3-13/h2-11H,12H2,1H3,(H,24,25,29)	BRHVOBDPKZAFNE-UHFFFAOYSA-N	96859	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-1-methyl-6-oxo-1,6- dihydro-[3,4'-bipyridine]-3'-carboxamide::US12509454, Compound 122	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96859	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96859&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361858	164038103							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130514	COc1ccc(C#N)cc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H16ClN5O3S/c1-31-20-7-4-15(11-25)10-18(20)19-12-26-9-8-17(19)21(30)27-22-28-29-23(33-22)32-13-14-2-5-16(24)6-3-14/h2-10,12H,13H2,1H3,(H,27,28,30)	MOHDLWSNFGMUCX-UHFFFAOYSA-N	96860	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(5-cyano-2- methoxyphenyl)isonicotinamide::US12509454, Compound 123	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96860	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96860&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361864	164038104							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130515	COc1cccc(F)c1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C22H16ClFN4O3S/c1-30-18-4-2-3-17(24)19(18)16-11-25-10-9-15(16)20(29)26-21-27-28-22(32-21)31-12-13-5-7-14(23)8-6-13/h2-11H,12H2,1H3,(H,26,27,29)	JXKLWVBRJUVBPV-UHFFFAOYSA-N	96861	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(2-fluoro-6- methoxyphenyl)isonicotinamide::US12509454, Compound 124	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96861	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96861&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361865	164038105							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130516	COc1cccc(Cl)c1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C22H16Cl2N4O3S/c1-30-18-4-2-3-17(24)19(18)16-11-25-10-9-15(16)20(29)26-21-27-28-22(32-21)31-12-13-5-7-14(23)8-6-13/h2-11H,12H2,1H3,(H,26,27,29)	UVIFGZDRSUDNMQ-UHFFFAOYSA-N	96862	3-(2-chloro-6-methoxyphenyl)-N-(5-((4- chlorobenzyl)oxy)-1,3,4-thiadiazol-2- yl)isonicotinamide::US12509454, Compound 125	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96862	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96862&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361874	164038106							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130517	N#Cc1ccccc1c2cnccc2C(=O)Nc4nnc(OCc3ccc(Cl)cc3)s4	InChI=1S/C22H14ClN5O2S/c23-16-7-5-14(6-8-16)13-30-22-28-27-21(31-22)26-20(29)18-9-10-25-12-19(18)17-4-2-1-3-15(17)11-24/h1-10,12H,13H2,(H,26,27,29)	ADASYBXUMZEZFK-UHFFFAOYSA-N	96863	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(2- cyanophenyl)isonicotinamide::US12509454, Compound 126	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96863	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96863&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361878	164038107							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130518	COc1cc(C#N)ccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H16ClN5O3S/c1-31-20-10-15(11-25)4-7-17(20)19-12-26-9-8-18(19)21(30)27-22-28-29-23(33-22)32-13-14-2-5-16(24)6-3-14/h2-10,12H,13H2,1H3,(H,27,28,30)	LIUHVPGAZWZFFX-UHFFFAOYSA-N	96864	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(4-cyano-2- methoxyphenyl)isonicotinamide::US12509454, Compound 127	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96864	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96864&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361879	164038108							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130519	COc1cccc(OC)c1-c1ccncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H19ClN4O4S/c1-30-18-4-3-5-19(31-2)20(18)16-10-11-25-12-17(16)21(29)26-22-27-28-23(33-22)32-13-14-6-8-15(24)9-7-14/h3-12H,13H2,1-2H3,(H,26,27,29)	BYYWLRAHXPZGOK-UHFFFAOYSA-N	96865	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-4-(2,6- dimethoxyphenyl)nicotinamide::US12509454, Compound 128	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96865	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96865&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361881	164038109							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130520	COc1ncccc1-c1ccncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C21H16ClN5O3S/c1-29-19-16(3-2-9-24-19)15-8-10-23-11-17(15)18(28)25-20-26-27-21(31-20)30-12-13-4-6-14(22)7-5-13/h2-11H,12H2,1H3,(H,25,26,28)	MBFXVIVAOOEHPX-UHFFFAOYSA-N	96866	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-methoxy-[3,4'- bipyridine]-3'-carboxamide::US12509454, Compound 129	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96866	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96866&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361882	164038110							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130521	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cnccc1-c1ccccc1OC(F)(F)F	InChI=1S/C22H14ClF3N4O3S/c23-14-7-5-13(6-8-14)12-32-21-30-29-20(34-21)28-19(31)17-11-27-10-9-15(17)16-3-1-2-4-18(16)33-22(24,25)26/h1-11H,12H2,(H,28,29,31)	QQSDXHLQMARQEY-UHFFFAOYSA-N	96867	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-4-(2- (trifluoromethoxy)phenyl)nicotinamide::US12509454, Compound 130	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96867	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96867&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361884	164038111							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130522	COc1cnccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C21H16ClN5O3S/c1-29-18-11-24-8-6-15(18)17-10-23-9-7-16(17)19(28)25-20-26-27-21(31-20)30-12-13-2-4-14(22)5-3-13/h2-11H,12H2,1H3,(H,25,26,28)	DUVWIUPOPJSICL-UHFFFAOYSA-N	96868	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3'-methoxy-[3,4'- bipyridine]-4-carboxamide::US12509454, Compound 131	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96868	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96868&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361886	164038112							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130523	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cnccc1-c1ccccc1C(F)(F)F	InChI=1S/C22H14ClF3N4O2S/c23-14-7-5-13(6-8-14)12-32-21-30-29-20(33-21)28-19(31)17-11-27-10-9-15(17)16-3-1-2-4-18(16)22(24,25)26/h1-11H,12H2,(H,28,29,31)	HXPGZVMHWRZSFH-UHFFFAOYSA-N	96869	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-4-(2- (trifluoromethyl)phenyl)nicotinamide::US12509454, Compound 132	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96869	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96869&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361887	164038113							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130524	COc1ccncc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C21H16ClN5O3S/c1-29-18-7-9-24-11-17(18)16-10-23-8-6-15(16)19(28)25-20-26-27-21(31-20)30-12-13-2-4-14(22)5-3-13/h2-11H,12H2,1H3,(H,25,26,28)	ANUOQTLFHMMQSQ-UHFFFAOYSA-N	96870	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-4'-methoxy-[3,3'- bipyridine]-4-carboxamide::US12509454, Compound 133	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96870	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96870&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361889	164038114							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130525	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1ccccc1OC1COC1	InChI=1S/C24H19ClN4O4S/c25-16-7-5-15(6-8-16)12-32-24-29-28-23(34-24)27-22(30)19-9-10-26-11-20(19)18-3-1-2-4-21(18)33-17-13-31-14-17/h1-11,17H,12-14H2,(H,27,28,30)	ZYVXOLLRWJTQDK-UHFFFAOYSA-N	96871	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-3-[2-(oxetan-3- yloxy)phenyl]pyridine-4-carboxamide::US12509454, Compound 134	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96871	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96871&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361890	164038115							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130526	CCc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H19ClN4O2S/c1-2-16-5-3-4-6-18(16)20-13-25-12-11-19(20)21(29)26-22-27-28-23(31-22)30-14-15-7-9-17(24)10-8-15/h3-13H,2,14H2,1H3,(H,26,27,29)	UPZKXWORLAZGSJ-UHFFFAOYSA-N	96872	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-3-(2- ethylphenyl)pyridine-4-carboxamide::US12509454, Compound 135	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96872	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96872&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361892	164038116							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130527	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1cccc2c1OCCN2	InChI=1S/C23H18ClN5O3S/c24-15-6-4-14(5-7-15)13-32-23-29-28-22(33-23)27-21(30)17-8-9-25-12-18(17)16-2-1-3-19-20(16)31-11-10-26-19/h1-9,12,26H,10-11,13H2,(H,27,28,30)	NSXQWBIPIMLBNP-UHFFFAOYSA-N	96873	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-3-(3,4-dihydro-2H-1,4- benzoxazin-8-yl)pyridine-4-carboxamide::US12509454, Compound 136	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96873	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96873&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361895	164038117							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130528	COc1ccccc1-c1cnc(CC#N)cc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C24H18ClN5O3S/c1-32-21-5-3-2-4-18(21)20-13-27-17(10-11-26)12-19(20)22(31)28-23-29-30-24(34-23)33-14-15-6-8-16(25)9-7-15/h2-9,12-13H,10,14H2,1H3,(H,28,29,31)	PQDSCCOOZJNQDI-UHFFFAOYSA-N	96874	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-2-(cyanomethyl)-5-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 137	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96874	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96874&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361896	164038118							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130529	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H19ClN4O3S/c1-14-11-18(17-5-3-4-6-20(17)30-2)19(12-25-14)21(29)26-22-27-28-23(32-22)31-13-15-7-9-16(24)10-8-15/h3-12H,13H2,1-2H3,(H,26,27,29)	WAVGMZVEMPEOHB-UHFFFAOYSA-N	96875	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-4-(2-methoxyphenyl)-6- methylpyridine-3-carboxamide::US12509454, Compound 138	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96875	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96875&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361898	164038119							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130530	CN1CCOc2c(-c3cnccc3C(=O)Nc3nnc(OCc4ccc(Cl)cc4)s3)cccc21	InChI=1S/C24H20ClN5O3S/c1-30-11-12-32-21-17(3-2-4-20(21)30)19-13-26-10-9-18(19)22(31)27-23-28-29-24(34-23)33-14-15-5-7-16(25)8-6-15/h2-10,13H,11-12,14H2,1H3,(H,27,28,31)	JBCKXULPHMBFES-UHFFFAOYSA-N	96876	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-3-(4-methyl-2,3-dihydro- 1,4-benzoxazin-8-yl)pyridine-4- carboxamide::US12509454, Compound 139	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96876	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96876&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361900	164038120							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130531	Cc1n[nH]c(C)c1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H17ClN6O2S/c1-11-17(12(2)25-24-11)16-9-22-8-7-15(16)18(28)23-19-26-27-20(30-19)29-10-13-3-5-14(21)6-4-13/h3-9H,10H2,1-2H3,(H,24,25)(H,23,26,28)	NRTLZOVMEXAEKP-UHFFFAOYSA-N	96877	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-3-(3,5-dimethyl-1H- pyrazol-4-yl)pyridine-4-carboxamide::US12509454, Compound 140	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96877	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96877&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361906	164038121							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130532	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(C3(C#N)CC3)cc2)s1	InChI=1S/C26H21N5O3S/c1-33-22-5-3-2-4-19(22)21-14-28-13-10-20(21)23(32)29-24-30-31-25(35-24)34-15-17-6-8-18(9-7-17)26(16-27)11-12-26/h2-10,13-14H,11-12,15H2,1H3,(H,29,30,32)	XUISKIZNTXAAFE-UHFFFAOYSA-N	96878	N-(5-[[4-(1- cyanocyclopropyl)phenyl]methoxy]- 1,3,4-thiadiazol-2-yl)-3-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 141	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96878	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96878&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361910	164038122							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130533	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1N1CCCn2nccc21	InChI=1S/C21H18ClN7O2S/c22-15-4-2-14(3-5-15)13-31-21-27-26-20(32-21)25-19(30)16-6-8-23-12-17(16)28-10-1-11-29-18(28)7-9-24-29/h2-9,12H,1,10-11,13H2,(H,25,26,30)	GCNLCRVKWJZNSB-UHFFFAOYSA-N	96879	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-3-[5H,6H,7H- pyrazolo[1,5-a]pyrimidin-4-yl]pyridine-4- carboxamide::US12509454, Compound 142	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96879	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96879&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361912	164038123							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130534	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1c(F)cccc1OC1COC1	InChI=1S/C24H18ClFN4O4S/c25-15-6-4-14(5-7-15)11-33-24-30-29-23(35-24)28-22(31)17-8-9-27-10-18(17)21-19(26)2-1-3-20(21)34-16-12-32-13-16/h1-10,16H,11-13H2,(H,28,29,31)	JZLWRASXQMTCRS-UHFFFAOYSA-N	96880	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(2-fluoro-6-(oxetan-3- yloxy)phenyl)isonicotinamide::US12509454, Compound 143	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96880	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96880&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361914	164038124							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130535	C[C@@H]1COC[C@@H](C)N1c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C21H22ClN5O3S/c1-13-10-29-11-14(2)27(13)18-9-23-8-7-17(18)19(28)24-20-25-26-21(31-20)30-12-15-3-5-16(22)6-4-15/h3-9,13-14H,10-12H2,1-2H3,(H,24,25,28)	FJDRHZZGZKCOOJ-UHFFFAOYSA-N	96881	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-((3R,5R)-3,5- dimethylmorpholino)isonicotinamide::US12509454, Compound 144	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96881	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96881&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361920	164038125							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130536	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2cccc3[nH]cnc23)s1	InChI=1S/C23H18N6O3S/c1-31-19-8-3-2-6-15(19)17-11-24-10-9-16(17)21(30)27-22-28-29-23(33-22)32-12-14-5-4-7-18-20(14)26-13-25-18/h2-11,13H,12H2,1H3,(H,25,26)(H,27,28,30)	XBFLEXMHAVSIJC-UHFFFAOYSA-N	96882	N-[5-(1H-1,3-benzodiazol-4-ylmethoxy)- 1,3,4-thiadiazol-2-yl]-3-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 145	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96882	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96882&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361921	164038126							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130537	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)c3c2cnn3C)s1	InChI=1S/C24H19ClN6O3S/c1-31-21-17(12-27-31)14(7-8-19(21)25)13-34-24-30-29-23(35-24)28-22(32)16-9-10-26-11-18(16)15-5-3-4-6-20(15)33-2/h3-12H,13H2,1-2H3,(H,28,29,32)	ZUWWMGPXBKGCPG-UHFFFAOYSA-N	96883	N-[5-[(7-chloro-1-methylindazol-4- yl)methoxy]-1,3,4-thiadiazol-2-yl]-3-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 146	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96883	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96883&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361922	164038127							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130538	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cc(C#CCO)ncc1-c1ccccc1OC(F)F	InChI=1S/C25H17ClF2N4O4S/c26-16-9-7-15(8-10-16)14-35-25-32-31-24(37-25)30-22(34)19-12-17(4-3-11-33)29-13-20(19)18-5-1-2-6-21(18)36-23(27)28/h1-2,5-10,12-13,23,33H,11,14H2,(H,30,31,34)	MOPSLDFFXSLTPC-UHFFFAOYSA-N	96884	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-5-[2- (difluoromethoxy)phenyl]-2-(3- hydroxyprop-1-yn-1-yl)pyridine-4- carboxamide::US12509454, Compound 147	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96884	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96884&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361925	164038128							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130539	COc1ccccc1-c1cnc(F)cc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C22H16ClFN4O3S/c1-30-18-5-3-2-4-15(18)17-11-25-19(24)10-16(17)20(29)26-21-27-28-22(32-21)31-12-13-6-8-14(23)9-7-13/h2-11H,12H2,1H3,(H,26,27,29)	MCZDAFBUMCQYOE-UHFFFAOYSA-N	96885	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-fluoro-5-(2- methoxyphenyl)isonicotinamide::US12509454, Compound 148	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96885	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96885&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361926	164038129							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130540	COc1ccccc1-n1cncc1C(=O)Nc1nnc(OCc2ccc(C3CC3)cc2)s1	InChI=1S/C23H21N5O3S/c1-30-20-5-3-2-4-18(20)28-14-24-12-19(28)21(29)25-22-26-27-23(32-22)31-13-15-6-8-16(9-7-15)17-10-11-17/h2-9,12,14,17H,10-11,13H2,1H3,(H,25,26,29)	VRDKTEVHZTUCBI-UHFFFAOYSA-N	96886	N-(5-((4-cyclopropylbenzyl)oxy)-1,3,4- thiadiazol-2-yl)-1-(2-methoxyphenyl)-1H- imidazole-5-carboxamide::US12509454, Compound 149	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96886	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96886&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361927	164038130							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130541	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1cccnc1-c1ccccc1Cl	InChI=1S/C21H14Cl2N4O2S/c22-14-9-7-13(8-10-14)12-29-21-27-26-20(30-21)25-19(28)16-5-3-11-24-18(16)15-4-1-2-6-17(15)23/h1-11H,12H2,(H,25,26,28)	OADCYNLYVPNQHQ-UHFFFAOYSA-N	96887	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-(2- chlorophenyl)nicotinamide::US12509454, Compound 150	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96887	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96887&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361928	164038131							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130542	COc1ccccc1-c1cnc(C#N)cc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H16ClN5O3S/c1-31-20-5-3-2-4-17(20)19-12-26-16(11-25)10-18(19)21(30)27-22-28-29-23(33-22)32-13-14-6-8-15(24)9-7-14/h2-10,12H,13H2,1H3,(H,27,28,30)	XLEBVHUPNPTYRQ-UHFFFAOYSA-N	96888	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-cyano-5-(2- methoxyphenyl)isonicotinamide::US12509454, Compound 151	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96888	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96888&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53361930	164038132							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130543	COc1ccccc1-c1cc(C(=O)O)ncc1C(=O)Nc1nnc(OCc2ccc(Br)cc2)s1	InChI=1S/C23H17BrN4O5S/c1-32-19-5-3-2-4-15(19)16-10-18(21(30)31)25-11-17(16)20(29)26-22-27-28-23(34-22)33-12-13-6-8-14(24)9-7-13/h2-11H,12H2,1H3,(H,30,31)(H,26,27,29)	SQIDFFWVTMRQND-UHFFFAOYSA-N	96889	5-([5-[(4-bromophenyl)methoxy]-1,3,4- thiadiazol-2-yl]carbamoyl)-4-(2- methoxyphenyl)pyridine-2-carboxylic acid::US12509454, Compound 152	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96889	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96889&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			53305546	164038133							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130544	COc1ccccc1-c1ccncc1C(=O)Nc1nnc(OCc2ccc(Br)cc2)s1	InChI=1S/C22H17BrN4O3S/c1-29-19-5-3-2-4-17(19)16-10-11-24-12-18(16)20(28)25-21-26-27-22(31-21)30-13-14-6-8-15(23)9-7-14/h2-12H,13H2,1H3,(H,25,26,28)	IPNNPZJWJLROLY-UHFFFAOYSA-N	96890	N-[5-[(4-bromophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-4-(2- methoxyphenyl)pyridine-3-carboxamide::US12509454, Compound 153	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96890	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96890&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			56588155	164038134							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130545	COc1ccccc1-c1cc(C#N)ncc1C(=O)Nc1nnc(OCCC2CC2)s1	InChI=1S/C21H19N5O3S/c1-28-18-5-3-2-4-15(18)16-10-14(11-22)23-12-17(16)19(27)24-20-25-26-21(30-20)29-9-8-13-6-7-13/h2-5,10,12-13H,6-9H2,1H3,(H,24,25,27)	UOERMFTWKLSPTQ-UHFFFAOYSA-N	96891	6-cyano-N-(5-(2-cyclopropylethoxy)- 1,3,4-thiadiazol-2-yl)-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 154	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96891	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96891&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			56588174	164038135							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130546	COc1cc(F)ccc1-c1ccncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C22H16ClFN4O3S/c1-30-19-10-15(24)6-7-17(19)16-8-9-25-11-18(16)20(29)26-21-27-28-22(32-21)31-12-13-2-4-14(23)5-3-13/h2-11H,12H2,1H3,(H,26,27,29)	JXDYTRVTANUODB-UHFFFAOYSA-N	96892	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-4-(4-fluoro-2- methoxyphenyl)pyridine-3-carboxamide::US12509454, Compound 155	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96892	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96892&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			56589281	164038136							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130547	COc1ccccc1-c1cc(C(F)(F)F)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H16ClF3N4O3S/c1-33-18-5-3-2-4-15(18)16-10-19(23(25,26)27)28-11-17(16)20(32)29-21-30-31-22(35-21)34-12-13-6-8-14(24)9-7-13/h2-11H,12H2,1H3,(H,29,30,32)	XUNMQNXGTHLRBT-UHFFFAOYSA-N	96893	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-4-(2-methoxyphenyl)-6- (trifluoromethyl)pyridine-3-carboxamide::US12509454, Compound 156	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96893	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96893&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			56589305	164038137							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130548	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2cccc(Cl)c2)s1	InChI=1S/C22H17ClN4O3S/c1-29-19-8-3-2-7-16(19)18-12-24-10-9-17(18)20(28)25-21-26-27-22(31-21)30-13-14-5-4-6-15(23)11-14/h2-12H,13H2,1H3,(H,25,26,28)	INBBCGMJBIGFPG-UHFFFAOYSA-N	96894	N-(5-((3-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(2- methoxyphenyl)isonicotinamide::US12509454, Compound 157	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96894	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96894&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			56589328	164038138							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130549	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)c(Cl)c2)s1	InChI=1S/C22H16Cl2N4O3S/c1-30-19-5-3-2-4-14(19)16-11-25-9-8-15(16)20(29)26-21-27-28-22(32-21)31-12-13-6-7-17(23)18(24)10-13/h2-11H,12H2,1H3,(H,26,27,29)	QWMLEHCMKTVISA-UHFFFAOYSA-N	96895	N-[5-[(3,4-dichlorophenyl)methoxy]- 1,3,4-thiadiazol-2-yl]-3-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 158	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96895	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96895&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			56589351	164038139							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130550	COc1c(C#N)cccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H16ClN5O3S/c1-31-20-15(11-25)3-2-4-17(20)19-12-26-10-9-18(19)21(30)27-22-28-29-23(33-22)32-13-14-5-7-16(24)8-6-14/h2-10,12H,13H2,1H3,(H,27,28,30)	CVSRQHQWKMXKEJ-UHFFFAOYSA-N	96896	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(3-cyano-2- methoxyphenyl)isonicotinamide::US12509454, Compound 159	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96896	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96896&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3240709	164038140							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130551	COc1cc(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c(-c2ccccc2OC)cn1	InChI=1S/C23H19ClN4O4S/c1-30-19-6-4-3-5-16(19)18-12-25-20(31-2)11-17(18)21(29)26-22-27-28-23(33-22)32-13-14-7-9-15(24)10-8-14/h3-12H,13H2,1-2H3,(H,26,27,29)	UEFXXIZSEDNFOD-UHFFFAOYSA-N	96897	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-2-methoxy-5-(2- methoxyphenyl)isonicotinamide::US12509454, Compound 160	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96897	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96897&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3243427	164038141							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130552	COc1ccccc1-c1cn2ccnc2cc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C24H18ClN5O3S/c1-32-20-5-3-2-4-17(20)19-13-30-11-10-26-21(30)12-18(19)22(31)27-23-28-29-24(34-23)33-14-15-6-8-16(25)9-7-15/h2-13H,14H2,1H3,(H,27,28,31)	SKASVGLLCNNLMI-UHFFFAOYSA-N	96898	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-6-(2- methoxyphenyl)imidazo[1,2-a]pyridine-7- carboxamide::US12509454, Compound 161	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96898	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96898&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3243722	164038142							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130553	Cc1n[nH]cc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C19H15ClN6O2S/c1-11-15(9-22-24-11)16-8-21-7-6-14(16)17(27)23-18-25-26-19(29-18)28-10-12-2-4-13(20)5-3-12/h2-9H,10H2,1H3,(H,22,24)(H,23,25,27)	HKHDMOZDPGKUJD-UHFFFAOYSA-N	96899	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(3-methyl-1H-pyrazol- 4-yl)isonicotinamide::US12509454, Compound 162	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96899	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96899&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1248737	164038143							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130554	COc1ccccc1-c1cc(CCC(N)=O)ncc1C(=O)Nc1nnc(CCc2ccc(Cl)cc2)s1	InChI=1S/C26H24ClN5O3S/c1-35-22-5-3-2-4-19(22)20-14-18(11-12-23(28)33)29-15-21(20)25(34)30-26-32-31-24(36-26)13-8-16-6-9-17(27)10-7-16/h2-7,9-10,14-15H,8,11-13H2,1H3,(H2,28,33)(H,30,32,34)	OYJQZYBFDKXAFT-UHFFFAOYSA-N	96900	6-(3-amino-3-oxopropyl)-N-(5-((4- chlorobenzyl)oxy)-1,3,4-thiadiazol-2-yl)- 4-(2-methoxyphenyl)nicotinamide::US12509454, Compound 163	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96900	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96900&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2957591	164038144							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130555	COc1ccccc1-c1cc(CCC#N)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C25H20ClN5O3S/c1-33-22-7-3-2-6-19(22)20-13-18(5-4-12-27)28-14-21(20)23(32)29-24-30-31-25(35-24)34-15-16-8-10-17(26)11-9-16/h2-3,6-11,13-14H,4-5,15H2,1H3,(H,29,30,32)	XLKWFIWMCGMLAS-UHFFFAOYSA-N	96901	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-6-(2-cyanoethyl)-4-(2- methoxyphenyl)pyridine-3-carboxamide::US12509454, Compound 164	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96901	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96901&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			725646	164038145							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130556	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1ccccc1OC1CC(O)C1	InChI=1S/C25H21ClN4O4S/c26-16-7-5-15(6-8-16)14-33-25-30-29-24(35-25)28-23(32)20-9-10-27-13-21(20)19-3-1-2-4-22(19)34-18-11-17(31)12-18/h1-10,13,17-18,31H,11-12,14H2,(H,28,29,32)	IBHLSTJCYJRXSZ-UHFFFAOYSA-N	96902	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(2-(3- hydroxycyclobutoxy)phenyl)isonicotinamide::US12509454, Compound 165	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96902	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96902&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1405179	164038146							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130557	COc1ccccc1-c1cc(CCO)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C24H21ClN4O4S/c1-32-21-5-3-2-4-18(21)19-12-17(10-11-30)26-13-20(19)22(31)27-23-28-29-24(34-23)33-14-15-6-8-16(25)9-7-15/h2-9,12-13,30H,10-11,14H2,1H3,(H,27,28,31)	NEWFHDFWPJXILG-UHFFFAOYSA-N	96903	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-6-(2-hydroxyethyl)-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 166	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96903	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96903&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1767835	164038147							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130558	COc1ccccc1C1C=C([C@@H](C)O)N=CC1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C24H23ClN4O4S/c1-14(30)20-11-18(17-5-3-4-6-21(17)32-2)19(12-26-20)22(31)27-23-28-29-24(34-23)33-13-15-7-9-16(25)10-8-15/h3-12,14,18-19,30H,13H2,1-2H3,(H,27,28,31)	FCCBTPAUAUFFJL-UHFFFAOYSA-N	96905	(R)-N-[5-[(4-chlorophenyl)methoxy]- 1,3,4-thiadiazol-2-yl]-6-(1-hydroxyethyl)- 4-(2-methoxyphenyl)pyridine-3- carboxamide ::US12509454, Compound 167	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96905	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96905&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3850578	164038149							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130559	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1cncn1-c1ccccc1OC(F)F	InChI=1S/C19H13ClF2N6O3S/c20-11-5-6-12(24-7-11)9-30-19-27-26-18(32-19)25-16(29)14-8-23-10-28(14)13-3-1-2-4-15(13)31-17(21)22/h1-8,10,17H,9H2,(H,25,26,29)	ZBQKGZFQNULIOD-UHFFFAOYSA-N	96906	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-3-[2- (difluoromethoxy)phenyl]imidazole-4- carboxamide::US12509454, Compound 168	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96906	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96906&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6161144	164038150							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130560	Cc1nn(C)cc1-c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C20H17ClN6O2S/c1-12-17(10-27(2)26-12)16-9-22-8-7-15(16)18(28)23-19-24-25-20(30-19)29-11-13-3-5-14(21)6-4-13/h3-10H,11H2,1-2H3,(H,23,24,28)	VYWYCAJEVLMMQN-UHFFFAOYSA-N	96907	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-3-(1,3-dimethylpyrazol-4- yl)pyridine-4-carboxamide::US12509454, Compound 169	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96907	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96907&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6538175	164038151							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130561	COc1cc(-c2ccccc2OC)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C22H18ClN5O4S/c1-30-18-6-4-3-5-15(18)16-9-19(31-2)25-11-17(16)20(29)26-21-27-28-22(33-21)32-12-14-8-7-13(23)10-24-14/h3-11H,12H2,1-2H3,(H,26,27,29)	IKGPIRXORVKPBI-UHFFFAOYSA-N	96908	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-6-(hydroxymethyl)- 4-(2-methoxyphenyl)pyridine-3- carboxamide::US12509454, Compound 170	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96908	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96908&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			5129679	164038152							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130562	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1-c1ccccc1CCO	InChI=1S/C23H19ClN4O3S/c24-17-7-5-15(6-8-17)14-31-23-28-27-22(32-23)26-21(30)19-9-11-25-13-20(19)18-4-2-1-3-16(18)10-12-29/h1-9,11,13,29H,10,12,14H2,(H,26,27,30)	YVIONOAGCJEXKJ-UHFFFAOYSA-N	96909	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(2-(2- hydroxyethyl)phenyl)isonicotinamide::US12509454, Compound 171	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96909	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96909&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1225514	164038153							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130563	N#Cc1ccc(OC2COC2)c(-c2cnccc2C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)c1	InChI=1S/C25H18ClN5O4S/c26-17-4-1-15(2-5-17)12-34-25-31-30-24(36-25)29-23(32)19-7-8-28-11-21(19)20-9-16(10-27)3-6-22(20)35-18-13-33-14-18/h1-9,11,18H,12-14H2,(H,29,30,32)	VGFOPHHIQFTZRG-UHFFFAOYSA-N	96910	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-3-(5-cyano-2-(oxetan-3- yloxy)phenyl)isonicotinamide::US12509454, Compound 172	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96910	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96910&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6889206	164038154							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130564	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1ccncc1N1CCOC2(CC2)C1	InChI=1S/C20H19ClN6O3S/c21-13-1-2-14(23-9-13)11-29-19-26-25-18(31-19)24-17(28)15-3-6-22-10-16(15)27-7-8-30-20(12-27)4-5-20/h1-3,6,9-10H,4-5,7-8,11-12H2,(H,24,25,28)	HCEXVGFRYFARII-UHFFFAOYSA-N	96911	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-3-[4-oxa-7- azaspiro[2.5]octan-7-yl]pyridine-4- carboxamide::US12509454, Compound 173	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96911	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96911&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			46497982	164038155							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130565	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2ccccc2)s1	InChI=1S/C22H18N4O3S/c1-28-19-10-6-5-9-16(19)18-13-23-12-11-17(18)20(27)24-21-25-26-22(30-21)29-14-15-7-3-2-4-8-15/h2-13H,14H2,1H3,(H,24,25,27)	YOICEYXQJDSECS-UHFFFAOYSA-N	96912	N-(5-(benzyloxy)-1,3,4-thiadiazol-2-yl)- 3-(2-methoxyphenyl)isonicotinamide::US12509454, Compound 174	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96912	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96912&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1522618	164038156							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130566	O=C(NC1NN=C(OCc2ccc(Cl)cc2)S1)c1ccncc1[C@@]12CCOC[C@@H]1C2	InChI=1S/C21H21ClN4O3S/c22-15-3-1-13(2-4-15)11-29-20-26-25-19(30-20)24-18(27)16-5-7-23-10-17(16)21-6-8-28-12-14(21)9-21/h1-5,7,10,14,19,25H,6,8-9,11-12H2,(H,24,27)	OLOSBCQNKSUFHD-UHFFFAOYSA-N	96913	3-((1R,6S)-3-oxabicyclo[4.1.0]heptan-6- yl)-N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)isonicotinamide::US12509454, Compound 175	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96913	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96913&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			16195141	164038157							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130567	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1N1C2CCC1COC2	InChI=1S/C21H20ClN5O3S/c22-14-3-1-13(2-4-14)10-30-21-26-25-20(31-21)24-19(28)17-7-8-23-9-18(17)27-15-5-6-16(27)12-29-11-15/h1-4,7-9,15-16H,5-6,10-12H2,(H,24,25,28)	OEHMJKOKZDIZAH-UHFFFAOYSA-N	96914	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-3-[3-oxa-8- azabicyclo[3.2.1]octan-8-yl]pyridine-4- carboxamide::US12509454, Compound 176	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96914	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96914&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6904296	164038158							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130568	N#Cc1cc(N2CCOC3(CC3)C2)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C22H19ClN6O3S/c23-15-3-1-14(2-4-15)12-31-21-28-27-20(33-21)26-19(30)17-11-25-16(10-24)9-18(17)29-7-8-32-22(13-29)5-6-22/h1-4,9,11H,5-8,12-13H2,(H,26,27,30)	DRHKGOUAVUYODH-UHFFFAOYSA-N	96915	N-[5-[(4-chlorophenyl)methoxy]-1,3,4- thiadiazol-2-yl]-6-cyano-4-[4-oxa-7- azaspiro[2.5]octan-7-yl]pyridine-3- carboxamide::US12509454, Compound 177	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96915	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96915&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			91899619	164038159							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130569	O=C(Nc1nnc(OCc2ccc(Cl)cc2)s1)c1ccncc1N1CCO[C@@H]2C[C@@H]21	InChI=1S/C20H18ClN5O3S/c21-13-3-1-12(2-4-13)11-29-20-25-24-19(30-20)23-18(27)14-5-6-22-10-16(14)26-7-8-28-17-9-15(17)26/h1-6,10,15,17H,7-9,11H2,(H,23,24,27)	XXRSVFZOIAOWJC-UHFFFAOYSA-N	96916	US12509454, Compound 178	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96916	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96916&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2982577	164038160							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130570	C[C@H]1C(=O)NCCN1c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C19H18ClN7O3S/c1-11-16(28)22-6-7-27(11)15-9-21-5-4-14(15)17(29)24-18-25-26-19(31-18)30-10-13-3-2-12(20)8-23-13/h2-5,8-9,11H,6-7,10H2,1H3,(H,22,28)(H,24,25,29)	CCPQRBRHTSOMDY-UHFFFAOYSA-N	96917	US12509454, Compound 179	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96917	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96917&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1239651	164038161							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130571	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2cccc3cn[nH]c23)s1	InChI=1S/C23H18N6O3S/c1-31-19-8-3-2-7-16(19)18-12-24-10-9-17(18)21(30)26-22-28-29-23(33-22)32-13-15-6-4-5-14-11-25-27-20(14)15/h2-12H,13H2,1H3,(H,25,27)(H,26,28,30)	BDGHRXAUQGGMSQ-UHFFFAOYSA-N	96918	N-[5-(3H-1,3-benzodiazol-4-ylmethoxy)- 1,3,4-thiadiazol-2-yl]-3-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 180	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96918	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96918&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			5055551	164038162							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130572	COc1ccccc1-c1cnccc1C(=O)Nc1nnc(OCc2cccc3[nH]ncc23)s1	InChI=1S/C23H18N6O3S/c1-31-20-8-3-2-6-15(20)18-11-24-10-9-16(18)21(30)26-22-28-29-23(33-22)32-13-14-5-4-7-19-17(14)12-25-27-19/h2-12H,13H2,1H3,(H,25,27)(H,26,28,30)	VAAIWTUFAGZXMW-UHFFFAOYSA-N	96919	N-[5-(1H-indazol-4-ylmethoxy)-1,3,4- thiadiazol-2-yl]-3-(2- methoxyphenyl)pyridine-4-carboxamide::US12509454, Compound 181	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96919	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96919&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			24789280	164038163							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130573	O=C(Nc1nnc(OCc2ccc(Cl)cn2)s1)c1ccncc1-c1c(F)cccc1OC(F)F	InChI=1S/C21H13ClF3N5O3S/c22-11-4-5-12(27-8-11)10-32-21-30-29-20(34-21)28-18(31)13-6-7-26-9-14(13)17-15(23)2-1-3-16(17)33-19(24)25/h1-9,19H,10H2,(H,28,29,31)	QZGULJMVAKPOTE-UHFFFAOYSA-N	96920	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-3-(2- (difluoromethoxy)-6- fluorophenyl)isonicotinamide::US12509454, Compound 182	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96920	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96920&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3177673	164038164							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130574	COc1cccc(F)c1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H18ClFN4O3S/c1-13-10-16(20-18(25)4-3-5-19(20)31-2)17(11-26-13)21(30)27-22-28-29-23(33-22)32-12-14-6-8-15(24)9-7-14/h3-11H,12H2,1-2H3,(H,27,28,30)	DKMMOJJZDOBHAS-UHFFFAOYSA-N	96921	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-4-(2-fluoro-6- methoxyphenyl)-6-methylnicotinamide::US12509454, Compound 183	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96921	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96921&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			24818794	164038165							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130575	COc1cccc(F)c1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C22H17ClFN5O3S/c1-12-8-15(19-17(24)4-3-5-18(19)31-2)16(10-25-12)20(30)27-21-28-29-22(33-21)32-11-14-7-6-13(23)9-26-14/h3-10H,11H2,1-2H3,(H,27,28,30)	QSLHRXULZFQUHQ-UHFFFAOYSA-N	96922	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-4-(2-fluoro-6- methoxyphenyl)-6-methylnicotinamide::US12509454, Compound 184	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96922	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96922&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			24980219	164038166							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130576	COc1cccc(F)c1-c1cc(C#N)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cc2)s1	InChI=1S/C23H15ClFN5O3S/c1-32-19-4-2-3-18(25)20(19)16-9-15(10-26)27-11-17(16)21(31)28-22-29-30-23(34-22)33-12-13-5-7-14(24)8-6-13/h2-9,11H,12H2,1H3,(H,28,29,31)	ZJCGFIGIDDAQGY-UHFFFAOYSA-N	96923	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-6-cyano-4-(2-fluoro-6- methoxyphenyl)nicotinamide::US12509454, Compound 185	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96923	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96923&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			24686216	164038167							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130577	COc1cccc(F)c1-c1cc(C#N)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C22H14ClFN6O3S/c1-32-18-4-2-3-17(24)19(18)15-7-14(8-25)27-10-16(15)20(31)28-21-29-30-22(34-21)33-11-13-6-5-12(23)9-26-13/h2-7,9-10H,11H2,1H3,(H,28,29,31)	WWGPUCGZTQMFOD-UHFFFAOYSA-N	96924	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-6-cyano-4-(2- fluoro-6-methoxyphenyl)nicotinamide::US12509454, Compound 186	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96924	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96924&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			25162571	164038168							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130578	C[C@H]1COC[C@H](C)N1c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C20H21ClN6O3S/c1-12-9-29-10-13(2)27(12)17-8-22-6-5-16(17)18(28)24-19-25-26-20(31-19)30-11-15-4-3-14(21)7-23-15/h3-8,12-13H,9-11H2,1-2H3,(H,24,25,28)	FFYHUXSJLSBMIM-UHFFFAOYSA-N	96925	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-3-((3S,5S)-3,5- dimethylmorpholino)isonicotinamide::US12509454, Compound 187	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96925	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96925&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			25163212	164038169							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130579	C[C@@H]1COC[C@@H](C)N1c1cnccc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C20H21ClN6O3S/c1-12-9-29-10-13(2)27(12)17-8-22-6-5-16(17)18(28)24-19-25-26-20(31-19)30-11-15-4-3-14(21)7-23-15/h3-8,12-13H,9-11H2,1-2H3,(H,24,25,28)	FFYHUXSJLSBMIM-UHFFFAOYSA-N	96926	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-3-((3R,5R)-3,5- dimethylmorpholino)isonicotinamide::US12509454, Compound 188	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96926	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96926&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			44142428	164038170							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130580	Cc1cc(-c2c(F)cccc2OC(F)F)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C23H16ClF3N4O3S/c1-12-9-15(19-17(25)3-2-4-18(19)34-21(26)27)16(10-28-12)20(32)29-22-30-31-23(35-22)33-11-13-5-7-14(24)8-6-13/h2-10,21H,11H2,1H3,(H,29,30,32)	CFGJVDUCGBRGKG-UHFFFAOYSA-N	96927	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-4-(2-(difluoromethoxy)- 6-fluorophenyl)-6-methylnicotinamide::US12509454, Compound 189	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96927	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96927&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			44142561	164038171							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130581	Cc1cc(-c2c(F)cccc2OC(F)F)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C22H15ClF3N5O3S/c1-11-7-14(18-16(24)3-2-4-17(18)34-20(25)26)15(9-27-11)19(32)29-21-30-31-22(35-21)33-10-13-6-5-12(23)8-28-13/h2-9,20H,10H2,1H3,(H,29,30,32)	MGGPTBBSGDNRQP-UHFFFAOYSA-N	96928	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-4-(2- (difluoromethoxy)-6-fluorophenyl)-6- methylnicotinamide::US12509454, Compound 190	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96928	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96928&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			44142568	164038172							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130582	COc1ccccc1-c1cnc(C)cc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C22H18ClN5O3S/c1-13-9-17(18(11-24-13)16-5-3-4-6-19(16)30-2)20(29)26-21-27-28-22(32-21)31-12-15-8-7-14(23)10-25-15/h3-11H,12H2,1-2H3,(H,26,27,29)	PRUGTBKIDLTHLI-UHFFFAOYSA-N	96929	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-5-(2- methoxyphenyl)-2-methylpyridine-4- carboxamide::US12509454, Compound 191	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96929	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96929&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			44263516	164038173							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130583	N#Cc1cc(-c2c(F)cccc2OC(F)F)c(C(=O)Nc2nnc(OCc3ccc(Cl)cc3)s2)cn1	InChI=1S/C23H13ClF3N5O3S/c24-13-6-4-12(5-7-13)11-34-23-32-31-22(36-23)30-20(33)16-10-29-14(9-28)8-15(16)19-17(25)2-1-3-18(19)35-21(26)27/h1-8,10,21H,11H2,(H,30,31,33)	HUQPFBFVMSJOFN-UHFFFAOYSA-N	96930	N-(5-((4-chlorobenzyl)oxy)-1,3,4- thiadiazol-2-yl)-6-cyano-4-(2- (difluoromethoxy)-6- fluorophenyl)nicotinamide::US12509454, Compound 192	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96930	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96930&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			56588566	164038174							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130584	N#Cc1cc(-c2c(F)cccc2OC(F)F)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C22H12ClF3N6O3S/c23-11-4-5-12(28-8-11)10-34-22-32-31-21(36-22)30-19(33)15-9-29-13(7-27)6-14(15)18-16(24)2-1-3-17(18)35-20(25)26/h1-6,8-9,20H,10H2,(H,30,31,33)	XSMXPDQGKLOILQ-UHFFFAOYSA-N	96931	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-6-cyano-4-(2- (difluoromethoxy)-6-fluorophenyl) nicotinamide::US12509454, Compound 193	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96931	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96931&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			645909	164038175							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130585	COc1cnccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C21H17ClN6O3S/c1-12-7-16(15-5-6-23-10-18(15)30-2)17(9-24-12)19(29)26-20-27-28-21(32-20)31-11-14-4-3-13(22)8-25-14/h3-10H,11H2,1-2H3,(H,26,27,29)	FBGRCWJRJPPGMQ-UHFFFAOYSA-N	96932	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-3'-methoxy-6- methyl-[4,4'-bipyridine]-3-carboxamide::US12509454, Compound 194	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96932	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96932&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			649833	164038176							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130586	COc1c(CO)cccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C23H20ClN5O4S/c1-13-8-18(17-5-3-4-14(11-30)20(17)32-2)19(10-25-13)21(31)27-22-28-29-23(34-22)33-12-16-7-6-15(24)9-26-16/h3-10,30H,11-12H2,1-2H3,(H,27,28,31)	OFWYHQRQNNICJR-UHFFFAOYSA-N	96933	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-4-[3- (hydroxymethyl)-2-methoxyphenyl]-6- methylpyridine-3-carboxamide::US12509454, Compound 195	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96933	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96933&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			652304	164038177							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130587	Cc1cc(-c2c(C)n[nH]c2C)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C20H18ClN7O2S/c1-10-6-15(17-11(2)25-26-12(17)3)16(8-22-10)18(29)24-19-27-28-20(31-19)30-9-14-5-4-13(21)7-23-14/h4-8H,9H2,1-3H3,(H,25,26)(H,24,27,29)	HNRMRRSNSQMCPT-UHFFFAOYSA-N	96934	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-4-(3,5-dimethyl- 1H-pyrazol-4-yl)-6methylnicotinamide::US12509454, Compound 196	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96934	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96934&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			666309	164038178							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130588	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCCc2ccc(Cl)cn2)s1	InChI=1S/C23H20ClN5O3S/c1-14-11-18(17-5-3-4-6-20(17)31-2)19(13-25-14)21(30)27-22-28-29-23(33-22)32-10-9-16-8-7-15(24)12-26-16/h3-8,11-13H,9-10H2,1-2H3,(H,27,28,30)	KPDVVRNGBWLNPX-UHFFFAOYSA-N	96935	N-(5-(2-(5-chloropyridin-2-yl)ethoxy)- 1,3,4-thiadiazol-2-yl)-4-(2- methoxyphenyl)-6-methylnicotinamide::US12509454, Compound 197	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96935	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96935&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2608898	164038179							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130589	Cc1cc(-c2cccc3c2OCCN3)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C23H19ClN6O3S/c1-13-9-17(16-3-2-4-19-20(16)32-8-7-25-19)18(11-26-13)21(31)28-22-29-30-23(34-22)33-12-15-6-5-14(24)10-27-15/h2-6,9-11,25H,7-8,12H2,1H3,(H,28,29,31)	PRCJLQOJVHQRJO-UHFFFAOYSA-N	96936	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-4-(3,4-dihydro-2H- benzo[b][1,4]oxazin-8-yl)-6- methylnicotinamide::US12509454, Compound 198	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96936	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96936&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2103131	164038180							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130590	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2cc(F)ccn2)s1	InChI=1S/C22H18FN5O3S/c1-13-9-17(16-5-3-4-6-19(16)30-2)18(11-25-13)20(29)26-21-27-28-22(32-21)31-12-15-10-14(23)7-8-24-15/h3-11H,12H2,1-2H3,(H,26,27,29)	QMVMLOAWCLYUKE-UHFFFAOYSA-N	96937	N-(5-((4-fluoropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-4-(2- methoxyphenyl)-6-methylnicotinamide::US12509454, Compound 199	DNA polymerase theta [1-899]			 375							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96937	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96937&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2323738	164038181							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130591	COc1ccc(CO)cc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C23H20ClN5O4S/c1-13-7-17(18-8-14(11-30)3-6-20(18)32-2)19(10-25-13)21(31)27-22-28-29-23(34-22)33-12-16-5-4-15(24)9-26-16/h3-10,30H,11-12H2,1-2H3,(H,27,28,31)	XYSHGHVDAYKGJS-UHFFFAOYSA-N	96938	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-4-(5- (hydroxymethyl)-2-methoxyphenyl)-6- methylnicotinamide::US12509454, Compound 200	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96938	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96938&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2082848	164038182							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130592	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@H](C)c2ccc(Cl)cc2)s1	InChI=1S/C24H21ClN4O3S/c1-14-12-19(18-6-4-5-7-21(18)31-3)20(13-26-14)22(30)27-23-28-29-24(33-23)32-15(2)16-8-10-17(25)11-9-16/h4-13,15H,1-3H3,(H,27,28,30)	NEUABXOSCNVBOZ-UHFFFAOYSA-N	96940	N-[5-[(1R)-1-(4-chlorophenyl)ethoxy]- 1,3,4-thiadiazol-2-yl]-4-(2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 201	DNA polymerase theta [1-899]			 750							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96940	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96940&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2941916	164038184							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130593	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(O[C@@H](C)c2ccc(Cl)cc2)s1	InChI=1S/C24H21ClN4O3S/c1-14-12-19(18-6-4-5-7-21(18)31-3)20(13-26-14)22(30)27-23-28-29-24(33-23)32-15(2)16-8-10-17(25)11-9-16/h4-13,15H,1-3H3,(H,27,28,30)	NEUABXOSCNVBOZ-UHFFFAOYSA-N	96941	N-[5-[(1S)-1-(4-chlorophenyl)ethoxy]- 1,3,4-thiadiazol-2-yl]-4-(2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 202	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96941	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96941&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			743142	164038185							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130594	Cc1cc(-c2ccccc2CO)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C22H18ClN5O3S/c1-13-8-18(17-5-3-2-4-14(17)11-29)19(10-24-13)20(30)26-21-27-28-22(32-21)31-12-16-7-6-15(23)9-25-16/h2-10,29H,11-12H2,1H3,(H,26,27,30)	OROBTPKFHIRBOD-UHFFFAOYSA-N	96942	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-4-[2- (hydroxymethyl)phenyl]-6- methylpyridine-3-carboxamide::US12509454, Compound 203	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96942	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96942&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			894605	164038186							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130595	COc1ccccc1-c1cc(CN)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C22H19ClN6O3S/c1-31-19-5-3-2-4-16(19)17-8-15(9-24)26-11-18(17)20(30)27-21-28-29-22(33-21)32-12-14-7-6-13(23)10-25-14/h2-8,10-11H,9,12,24H2,1H3,(H,27,28,30)	MOZQQJUJCAUQFG-UHFFFAOYSA-N	96943	6-(aminomethyl)-N-[5-[(5-chloropyridin- 2-yl)methoxy]-1,3,4-thiadiazol-2-yl]-4-(2- methoxyphenyl)pyridine-3-carboxamide::US12509454, Compound 204	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96943	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96943&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1266779	164038187							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130596	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(C)cn2)s1	InChI=1S/C23H21N5O3S/c1-14-8-9-16(25-11-14)13-31-23-28-27-22(32-23)26-21(29)19-12-24-15(2)10-18(19)17-6-4-5-7-20(17)30-3/h4-12H,13H2,1-3H3,(H,26,27,29)	VUYCFXMYMVHCFM-UHFFFAOYSA-N	96944	4-(2-methoxyphenyl)-6-methyl-N-(5-((5- methylpyridin-2-yl)methoxy)-1,3,4- thiadiazol-2-yl)nicotinamide::US12509454, Compound 205	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96944	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96944&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			874111	164038188							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130597	COc1cccc(F)c1-c1cc(CO)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C22H17ClFN5O4S/c1-32-18-4-2-3-17(24)19(18)15-7-14(10-30)26-9-16(15)20(31)27-21-28-29-22(34-21)33-11-13-6-5-12(23)8-25-13/h2-9,30H,10-11H2,1H3,(H,27,28,31)	WRYVLZSMAHSTIH-UHFFFAOYSA-N	96945	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-4-(2-fluoro-6- methoxyphenyl)-6- (hydroxymethyl)pyridine-3-carboxamide::US12509454, Compound 206	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96945	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96945&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6324568	164038189							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130598	COc1ccccc1-c1cc(C(C)(C)O)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C24H22ClN5O4S/c1-24(2,32)20-10-17(16-6-4-5-7-19(16)33-3)18(12-27-20)21(31)28-22-29-30-23(35-22)34-13-15-9-8-14(25)11-26-15/h4-12,32H,13H2,1-3H3,(H,28,29,31)	ZGKRMSCAIMNKHA-UHFFFAOYSA-N	96946	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-6-(2- hydroxypropan-2-yl)-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 207	DNA polymerase theta [1-899]			>1000							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96946	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96946&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			777454	164038190							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130599	Cc1cc(-c2cccc3c2OC(F)(F)O3)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C22H14ClF2N5O4S/c1-11-7-15(14-3-2-4-17-18(14)34-22(24,25)33-17)16(9-26-11)19(31)28-20-29-30-21(35-20)32-10-13-6-5-12(23)8-27-13/h2-9H,10H2,1H3,(H,28,29,31)	ROZJVDJZVVMVGG-UHFFFAOYSA-N	96947	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-4-(2,2- difluorobenzo[d][1,3]dioxol-4-yl)-6- methylnicotinamide::US12509454, Compound 208	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96947	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96947&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			761945	164038191							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130600	COc1ccccc1-c1cncnc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C20H15ClN6O3S/c1-29-16-5-3-2-4-14(16)15-9-22-11-24-17(15)18(28)25-19-26-27-20(31-19)30-10-13-7-6-12(21)8-23-13/h2-9,11H,10H2,1H3,(H,25,26,28)	XYJLDIAYXLTPRW-UHFFFAOYSA-N	96948	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-5-(2- methoxyphenyl)pyrimidine-4- carboxamide::US12509454, Compound 209	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96948	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96948&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			738011	164038192							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130601	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ncccc2F)s1	InChI=1S/C22H18FN5O3S/c1-13-10-15(14-6-3-4-8-19(14)30-2)16(11-25-13)20(29)26-21-27-28-22(32-21)31-12-18-17(23)7-5-9-24-18/h3-11H,12H2,1-2H3,(H,26,27,29)	JACRIXDAWCDGIP-UHFFFAOYSA-N	96949	N-[5-[(3-fluoropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-4-(2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 210	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96949	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96949&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			941675	164038193							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130602	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2cccc(F)n2)s1	InChI=1S/C22H18FN5O3S/c1-13-10-16(15-7-3-4-8-18(15)30-2)17(11-24-13)20(29)26-21-27-28-22(32-21)31-12-14-6-5-9-19(23)25-14/h3-11H,12H2,1-2H3,(H,26,27,29)	JUUVBGRFMFZUPI-UHFFFAOYSA-N	96950	N-[5-[(6-fluoropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-4-(2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 211	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96950	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96950&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3751638	164038194							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130603	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2cnc(Cl)cn2)s1	InChI=1S/C21H17ClN6O3S/c1-12-7-15(14-5-3-4-6-17(14)30-2)16(9-23-12)19(29)26-20-27-28-21(32-20)31-11-13-8-25-18(22)10-24-13/h3-10H,11H2,1-2H3,(H,26,27,29)	UPJLRUHNXRAYOD-UHFFFAOYSA-N	96951	N-[5-[(5-chloropyrazin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-4-(2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 212	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96951	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96951&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1518670	164038195							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130604	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)c3[nH]ncc23)s1	InChI=1S/C24H19ClN6O3S/c1-13-9-16(15-5-3-4-6-20(15)33-2)18(10-26-13)22(32)28-23-30-31-24(35-23)34-12-14-7-8-19(25)21-17(14)11-27-29-21/h3-11H,12H2,1-2H3,(H,27,29)(H,28,30,32)	LRMKXDACTXDDSU-UHFFFAOYSA-N	96952	N-[5-[(7-chloro-1H-indazol-4- yl)methoxy]-1,3,4-thiadiazol-2-yl]-4-(2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 213	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96952	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96952&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2846028	164038196							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130605	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(C3CC3)cn2)s1	InChI=1S/C25H23N5O3S/c1-15-11-20(19-5-3-4-6-22(19)32-2)21(13-26-15)23(31)28-24-29-30-25(34-24)33-14-18-10-9-17(12-27-18)16-7-8-16/h3-6,9-13,16H,7-8,14H2,1-2H3,(H,28,29,31)	HTUHOWGWZNJHAA-UHFFFAOYSA-N	96953	N-(5-((5-cyclopropylpyridin-2- yl)methoxy)-1,3,4-thiadiazol-2-yl)-4-(2- methoxyphenyl)-6-methylnicolinamide::US12509454, Compound 214	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96953	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96953&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			787406	164038197							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130606	COc1ccccc1-c1c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cnc(C)c1F	InChI=1S/C22H17ClFN5O3S/c1-12-19(24)18(15-5-3-4-6-17(15)31-2)16(10-25-12)20(30)27-21-28-29-22(33-21)32-11-14-8-7-13(23)9-26-14/h3-10H,11H2,1-2H3,(H,27,28,30)	XTYIMIQGHDGMRE-UHFFFAOYSA-N	96954	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-5-fluoro-4-(2- methoxyphenyl)-6-methylnicotinamide::US12509454, Compound 215	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96954	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96954&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			736985	164038198							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130607	COc1ccccc1-c1cc(C2CC2)ncc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C24H20ClN5O3S/c1-32-21-5-3-2-4-17(21)18-10-20(14-6-7-14)27-12-19(18)22(31)28-23-29-30-24(34-23)33-13-16-9-8-15(25)11-26-16/h2-5,8-12,14H,6-7,13H2,1H3,(H,28,29,31)	YOTDHFWSUBFYSO-UHFFFAOYSA-N	96955	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-6-cyclopropyl-4-(2- methoxyphenyl)pyridine-3-carboxamide::US12509454, Compound 216	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96955	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96955&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3448825	164038199							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130608	COc1cccc(F)c1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(C3(C#N)CC3)cn2)s1	InChI=1S/C26H21FN6O3S/c1-15-10-18(22-20(27)4-3-5-21(22)35-2)19(12-29-15)23(34)31-24-32-33-25(37-24)36-13-17-7-6-16(11-30-17)26(14-28)8-9-26/h3-7,10-12H,8-9,13H2,1-2H3,(H,31,32,34)	XTSOCNTYZHJISS-UHFFFAOYSA-N	96956	N-(5-((5-(1-cyanocyclopropyl)pyridin-2- yl)methoxy)-1,3,4-thiadiazol-2-yl)-4-(2- fluoro-6-methoxyphenyl)-6- methylnicotinamide::US12509454, Compound 217	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96956	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96956&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			2445782	164038200							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130609	Cc1cc(-c2ccccc2OC(F)F)c(C(=O)Nc2nnc(OCc3ccc(C4(C#N)CC4)cn3)s2)cn1	InChI=1S/C26H20F2N6O3S/c1-15-10-19(18-4-2-3-5-21(18)37-23(27)28)20(12-30-15)22(35)32-24-33-34-25(38-24)36-13-17-7-6-16(11-31-17)26(14-29)8-9-26/h2-7,10-12,23H,8-9,13H2,1H3,(H,32,33,35)	HSBWTKPKBVWFRZ-UHFFFAOYSA-N	96957	N-(5-[[5-(1-cyanocyclopropyl)pyridin-2- yl]methoxy]-1,3,4-thiadiazol-2-yl)-4-[2- (difluoromethoxy)phenyl]-6- methylpyridine-3-carboxamide::US12509454, Compound 218	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96957	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96957&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			9668341	164038201							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130610	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(C#N)cn2)s1	InChI=1S/C23H18N6O3S/c1-14-9-18(17-5-3-4-6-20(17)31-2)19(12-25-14)21(30)27-22-28-29-23(33-22)32-13-16-8-7-15(10-24)11-26-16/h3-9,11-12H,13H2,1-2H3,(H,27,28,30)	HZXJOUKXBDSRDV-UHFFFAOYSA-N	96959	N-(5-((5-cyanopyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-4-(2- methoxyphenyl)-6-methylnicotinamide::US12509454, Compound 219	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96959	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96959&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1617983	164038203							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130611	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(C3(C#N)CC3)cn2)s1	InChI=1S/C26H22N6O3S/c1-16-11-20(19-5-3-4-6-22(19)34-2)21(13-28-16)23(33)30-24-31-32-25(36-24)35-14-18-8-7-17(12-29-18)26(15-27)9-10-26/h3-8,11-13H,9-10,14H2,1-2H3,(H,30,31,33)	OCIRSVWQKVLJLZ-UHFFFAOYSA-N	96960	N-(5-[[5-(1-cyanocyclopropyl)pyridin-2- yl]methoxy]-1,3,4-thiadiazol-2-yl)-4-(2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 220	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96960	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96960&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			600062	164038204							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130612	COc1ccccc1-c1cc(C)ncc1C(=O)Nc1nnc(OCc2ccc(F)cn2)s1	InChI=1S/C22H18FN5O3S/c1-13-9-17(16-5-3-4-6-19(16)30-2)18(11-24-13)20(29)26-21-27-28-22(32-21)31-12-15-8-7-14(23)10-25-15/h3-11H,12H2,1-2H3,(H,26,27,29)	XAOXEQVYVJNWHN-UHFFFAOYSA-N	96961	N-[5-[(5-fluoropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-4-(2- methoxyphenyl)-6-methylpyridine-3- carboxamide::US12509454, Compound 221	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96961	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96961&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			9587473	164038205							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130613	COc1cc(-c2ccccc2OC)c(C(=O)Nc2nnc(OCc3ccc(Cl)cn3)s2)cn1	InChI=1S/C22H18ClN5O4S/c1-30-18-6-4-3-5-15(18)16-9-19(31-2)25-11-17(16)20(29)26-21-27-28-22(33-21)32-12-14-8-7-13(23)10-24-14/h3-11H,12H2,1-2H3,(H,26,27,29)	IKGPIRXORVKPBI-UHFFFAOYSA-N	96962	N-(5-((5-chloropyridin-2-yl)methoxy)- 1,3,4-thiadiazol-2-yl)-6-methoxy-4-(2- methoxyphenyl)nicotinamide::US12509454, Compound 222	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96962	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96962&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			1266353	164038206							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130614	COc1ccccc1-c1cc2cnnn2cc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C22H16ClN7O3S/c1-32-19-5-3-2-4-16(19)17-8-15-10-25-29-30(15)11-18(17)20(31)26-21-27-28-22(34-21)33-12-14-7-6-13(23)9-24-14/h2-11H,12H2,1H3,(H,26,27,31)	PHXOHFCCKDPPOB-UHFFFAOYSA-N	96964	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-5-(2- methoxyphenyl)-[1,2,3]triazolo[1,5- a]pyridine-6-carboxamide::US12509454, Compound 223	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96964	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96964&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			6254849	164038208							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																																		
130615	COc1ccccc1-c1cc2cncn2cc1C(=O)Nc1nnc(OCc2ccc(Cl)cn2)s1	InChI=1S/C23H17ClN6O3S/c1-32-20-5-3-2-4-17(20)18-8-16-10-25-13-30(16)11-19(18)21(31)27-22-28-29-23(34-22)33-12-15-7-6-14(24)9-26-15/h2-11,13H,12H2,1H3,(H,27,28,31)	AVKNHBKZZAXUMS-UHFFFAOYSA-N	96965	N-[5-[(5-chloropyridin-2-yl)methoxy]- 1,3,4-thiadiazol-2-yl]-7-(2- methoxyphenyl)imidazo[1,5-a]pyridine-6- carboxamide::US12509454, Compound 224	DNA polymerase theta [1-899]			<200							US Patent		10.7270/Q29W0M9V			US12509454	Barsanti, PA; Beck, HP; Fleury, M; Knox, JE; McSpadden, ED; Jones, BT; Martinez, LP; Pei, Z; Wang, C	12/30/2025	5/11/2026	Ideaya Biosciences	http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=96965	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=2059&target=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search	http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=96965&enzyme=DNA+polymerase+theta+%5B1-899%5D&column=ki&startPg=0&Increment=50&submit=Search			3782251	164038209							1	MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWN	9OSY,9OSW,9BPA,9BP9,9ASL,9ASK,9ASJ,8W0A,5A9J,9BHA,9BH9,9BH8,9BH7,9BH6,5AGA,5A9F	DNA polymerase theta	DPOLQ_HUMAN	O75417	O95160 Q6VMB5