BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 130872 CNCc1cc(-c2ccc(OCc3cccnc3F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C23H20F2N4O3S/c1-26-12-16-10-22(29(14-16)33(30,31)19-5-3-8-27-13-19)20-7-6-18(11-21(20)24)32-15-17-4-2-9-28-23(17)25/h2-11,13-14,26H,12,15H2,1H3 IQABLRDGQRVIDS-UHFFFAOYSA-N 97143 US20260001864, Compound A1 Potassium-transporting ATPase alpha chain 1 Homo sapiens 66.7 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97143 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97143&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 4153765 164038387 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130873 CNCc1cc(-c2ccc(OCc3cccnc3C)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H23FN4O3S/c1-17-19(5-3-10-28-17)16-32-20-7-8-22(23(25)12-20)24-11-18(13-26-2)15-29(24)33(30,31)21-6-4-9-27-14-21/h3-12,14-15,26H,13,16H2,1-2H3 ANLIEVPRRMBIPY-UHFFFAOYSA-N 97144 US20260001864, Compound A5 Potassium-transporting ATPase alpha chain 1 Homo sapiens 169 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97144 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97144&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 20968908 164038388 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130874 CNCc1cc(-c2ccc(OCC3CC3(F)F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C21H20F3N3O3S/c1-25-10-14-7-20(27(12-14)31(28,29)17-3-2-6-26-11-17)18-5-4-16(8-19(18)22)30-13-15-9-21(15,23)24/h2-8,11-12,15,25H,9-10,13H2,1H3 FJWLCYHPANPGAA-UHFFFAOYSA-N 97145 US20260001864, Compound A9 Potassium-transporting ATPase alpha chain 1 Homo sapiens 33.8 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97145 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97145&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 20919845 164038389 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130875 CNCc1cc(-c2ccc(OCC3COC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C21H22FN3O4S/c1-23-9-15-7-21(25(11-15)30(26,27)18-3-2-6-24-10-18)19-5-4-17(8-20(19)22)29-14-16-12-28-13-16/h2-8,10-11,16,23H,9,12-14H2,1H3 OQVILUIRZIRYDN-UHFFFAOYSA-N 97146 US20260001864, Compound A12 Potassium-transporting ATPase alpha chain 1 Homo sapiens 119 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97146 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97146&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24790916 164038390 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130876 CNCc1cc(-c2ccc(OCc3cccnc3C)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H23FN4O3S/c1-17-19(5-3-10-28-17)16-32-20-7-8-22(23(25)12-20)24-11-18(13-26-2)15-29(24)33(30,31)21-6-4-9-27-14-21/h3-12,14-15,26H,13,16H2,1-2H3 ANLIEVPRRMBIPY-UHFFFAOYSA-N 97147 US20260001864, Compound A2 Potassium-transporting ATPase alpha chain 1 Homo sapiens 155 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97147 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97147&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24791438 164038391 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130877 CNCc1cc(-c2ccc(OCc3ncccc3F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C23H20F2N4O3S/c1-26-12-16-10-23(29(14-16)33(30,31)18-4-2-8-27-13-18)19-7-6-17(11-21(19)25)32-15-22-20(24)5-3-9-28-22/h2-11,13-14,26H,12,15H2,1H3 JZGAMCAUVSATOY-UHFFFAOYSA-N 97148 US20260001864, Compound A6 Potassium-transporting ATPase alpha chain 1 Homo sapiens 157 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97148 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97148&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24792082 164038392 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130878 CNCc1cc(-c2ccc(OCC3CC3(F)F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C21H20F3N3O3S/c1-25-10-14-7-20(27(12-14)31(28,29)17-3-2-6-26-11-17)18-5-4-16(8-19(18)22)30-13-15-9-21(15,23)24/h2-8,11-12,15,25H,9-10,13H2,1H3 FJWLCYHPANPGAA-UHFFFAOYSA-N 97149 US20260001864, Compound A10 Potassium-transporting ATPase alpha chain 1 Homo sapiens 27.7 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97149 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97149&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24817418 164038393 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130879 CNCc1cc(-c2ccc(OCC3CCOC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C22H24FN3O4S/c1-24-11-17-9-22(26(13-17)31(27,28)19-3-2-7-25-12-19)20-5-4-18(10-21(20)23)30-15-16-6-8-29-14-16/h2-5,7,9-10,12-13,16,24H,6,8,11,14-15H2,1H3 HYLHXVFEWZTQHV-UHFFFAOYSA-N 97151 US20260001864, Compound A13 Potassium-transporting ATPase alpha chain 1 Homo sapiens 128 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97151 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97151&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24817872 164038395 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130880 CNCc1cc(-c2ccc(OCc3cnn(C)c3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C22H22FN5O3S/c1-24-10-16-8-22(28(14-16)32(29,30)19-4-3-7-25-12-19)20-6-5-18(9-21(20)23)31-15-17-11-26-27(2)13-17/h3-9,11-14,24H,10,15H2,1-2H3 CIFXESWYEXSVEO-UHFFFAOYSA-N 97152 US20260001864, Compound A3 Potassium-transporting ATPase alpha chain 1 Homo sapiens 51.6 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97152 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97152&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24819426 164038396 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130881 CNCc1cc(-c2ccc(OCc3ccn(C)n3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C22H22FN5O3S/c1-24-12-16-10-22(28(14-16)32(29,30)19-4-3-8-25-13-19)20-6-5-18(11-21(20)23)31-15-17-7-9-27(2)26-17/h3-11,13-14,24H,12,15H2,1-2H3 OQUSJLYDIWYRCG-UHFFFAOYSA-N 97153 US20260001864, Compound A8 Potassium-transporting ATPase alpha chain 1 Homo sapiens 18.4 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97153 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97153&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24819530 164038397 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130882 CNCc1cc(-c2ccc(OCC3CO3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C20H20FN3O4S/c1-22-9-14-7-20(24(11-14)29(25,26)17-3-2-6-23-10-17)18-5-4-15(8-19(18)21)27-12-16-13-28-16/h2-8,10-11,16,22H,9,12-13H2,1H3 USUXVBSQBVOUOQ-UHFFFAOYSA-N 97154 US20260001864, Compound A11 Potassium-transporting ATPase alpha chain 1 Homo sapiens 14.1 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97154 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97154&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3306 164038398 DB08985 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130883 CNCc1cc(-c2ccc(OCC3COCCO3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C22H24FN3O5S/c1-24-11-16-9-22(26(13-16)32(27,28)19-3-2-6-25-12-19)20-5-4-17(10-21(20)23)31-15-18-14-29-7-8-30-18/h2-6,9-10,12-13,18,24H,7-8,11,14-15H2,1H3 SHGLEMAJFDWZCT-UHFFFAOYSA-N 97155 US20260001864, Compound 1 Potassium-transporting ATPase alpha chain 1 Homo sapiens 585 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97155 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97155&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2811299 164038399 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130884 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2ccc(C)c(F)c2)c1 InChI=1S/C25H28F2N2O4S/c1-17-3-5-21(13-23(17)26)34(30,31)29-15-19(14-28-2)11-25(29)22-6-4-20(12-24(22)27)33-16-18-7-9-32-10-8-18/h3-6,11-13,15,18,28H,7-10,14,16H2,1-2H3 URLMLIBKRBGJGF-UHFFFAOYSA-N 97156 US20260001864, Compound 26 Potassium-transporting ATPase alpha chain 1 Homo sapiens 202 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97156 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97156&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 71821 164038400 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130885 CNCc1cn(S(=O)(=O)c2cccnc2)c(-c2ccc(OCC3CC3)cc2F)c1F InChI=1S/C21H21F2N3O3S/c1-24-10-15-12-26(30(27,28)17-3-2-8-25-11-17)21(20(15)23)18-7-6-16(9-19(18)22)29-13-14-4-5-14/h2-3,6-9,11-12,14,24H,4-5,10,13H2,1H3 IYWJTIAPVAUONB-UHFFFAOYSA-N 97157 US20260001864, Compound 51 Potassium-transporting ATPase alpha chain 1 Homo sapiens 35.2 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97157 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97157&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3204333 164038401 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130886 CNCc1cc(-c2ccc(O[C@H](C)c3c(Cl)ccc(F)c3Cl)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H21Cl2F2N3O3S/c1-15(24-20(26)7-8-21(28)25(24)27)35-17-5-6-19(22(29)11-17)23-10-16(12-30-2)14-32(23)36(33,34)18-4-3-9-31-13-18/h3-11,13-15,30H,12H2,1-2H3 FNMQVDPHZQVISS-UHFFFAOYSA-N 97158 US20260001864, Compound 76 Potassium-transporting ATPase alpha chain 1 Homo sapiens 470 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97158 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97158&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24980848 164038402 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130887 CNCc1cc(-c2ccc(OCC3CCC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C22H24FN3O3S/c1-24-12-17-10-22(26(14-17)30(27,28)19-6-3-9-25-13-19)20-8-7-18(11-21(20)23)29-15-16-4-2-5-16/h3,6-11,13-14,16,24H,2,4-5,12,15H2,1H3 QUIFZYWYLRFAQE-UHFFFAOYSA-N 97159 US20260001864, Compound 2 Potassium-transporting ATPase alpha chain 1 Homo sapiens 24.5 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97159 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97159&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24981189 164038403 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130888 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cc(F)cc(F)c2)c1 InChI=1S/C24H25F3N2O4S/c1-28-13-17-8-24(29(14-17)34(30,31)21-10-18(25)9-19(26)11-21)22-3-2-20(12-23(22)27)33-15-16-4-6-32-7-5-16/h2-3,8-12,14,16,28H,4-7,13,15H2,1H3 HWYWEXVYHBPIOB-UHFFFAOYSA-N 97161 US20260001864, Compound 27 Potassium-transporting ATPase alpha chain 1 Homo sapiens 38.7 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97161 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97161&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16196350 164038405 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130889 CNCc1cc(-c2ccc(OCC(C)(C)O)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C21H24FN3O4S/c1-21(2,26)14-29-16-6-7-18(19(22)10-16)20-9-15(11-23-3)13-25(20)30(27,28)17-5-4-8-24-12-17/h4-10,12-13,23,26H,11,14H2,1-3H3 PWVIJJOYIKUMRW-UHFFFAOYSA-N 97163 US20260001864, Compound 52 Potassium-transporting ATPase alpha chain 1 Homo sapiens 372 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97163 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97163&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 9261962 164038407 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130890 CNCc1cc(-c2ccc(OCc3ccsc3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C22H20FN3O3S2/c1-24-11-17-9-22(26(13-17)31(27,28)19-3-2-7-25-12-19)20-5-4-18(10-21(20)23)29-14-16-6-8-30-15-16/h2-10,12-13,15,24H,11,14H2,1H3 JCZIDIROEVRSOX-UHFFFAOYSA-N 97164 US20260001864, Compound 77 Potassium-transporting ATPase alpha chain 1 Homo sapiens 120 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97164 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97164&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16306739 164038408 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130891 CNCc1cc(-c2ccc(OCC3CCCC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C23H26FN3O3S/c1-25-13-18-11-23(27(15-18)31(28,29)20-7-4-10-26-14-20)21-9-8-19(12-22(21)24)30-16-17-5-2-3-6-17/h4,7-12,14-15,17,25H,2-3,5-6,13,16H2,1H3 GJPWTLAHDLAONX-UHFFFAOYSA-N 97165 US20260001864, Compound 3 Potassium-transporting ATPase alpha chain 1 Homo sapiens 20.9 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97165 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97165&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2534514 164038409 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130892 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(C#N)c2)c1 InChI=1S/C25H26FN3O4S/c1-28-15-20-12-25(29(16-20)34(30,31)22-4-2-3-19(11-22)14-27)23-6-5-21(13-24(23)26)33-17-18-7-9-32-10-8-18/h2-6,11-13,16,18,28H,7-10,15,17H2,1H3 RXZJRKMOZDNOTG-UHFFFAOYSA-N 97166 US20260001864, Compound 28 Potassium-transporting ATPase alpha chain 1 Homo sapiens 30.8 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97166 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97166&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16235315 164038410 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130893 CNCc1cc(-c2ccc(OC[C@@H]3C[C@@H]3F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C21H21F2N3O3S/c1-24-10-14-7-21(26(12-14)30(27,28)17-3-2-6-25-11-17)18-5-4-16(9-20(18)23)29-13-15-8-19(15)22/h2-7,9,11-12,15,19,24H,8,10,13H2,1H3 BAAWCCSHPBAJSE-UHFFFAOYSA-N 97167 US20260001864, Compound 53 Potassium-transporting ATPase alpha chain 1 Homo sapiens 56.1 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97167 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97167&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2537601 164038411 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130894 CNCc1cc(-c2ccc(OCc3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2cccc(Cl)c2)c1 InChI=1S/C25H20ClF3N2O3S/c1-30-13-16-9-25(31(14-16)35(32,33)21-4-2-3-18(26)11-21)22-7-6-20(12-24(22)29)34-15-17-10-19(27)5-8-23(17)28/h2-12,14,30H,13,15H2,1H3 XKBOSLFCYBPKPO-UHFFFAOYSA-N 97168 US20260001864, Compound 78 Potassium-transporting ATPase alpha chain 1 Homo sapiens 98.5 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97168 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97168&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3932658 164038412 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130895 CNCc1cc(-c2ccc(OCC3CCCCC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H28FN3O3S/c1-26-14-19-12-24(28(16-19)32(29,30)21-8-5-11-27-15-21)22-10-9-20(13-23(22)25)31-17-18-6-3-2-4-7-18/h5,8-13,15-16,18,26H,2-4,6-7,14,17H2,1H3 JFWFHQAFEIBBKT-UHFFFAOYSA-N 97169 US20260001864, Compound 4 Potassium-transporting ATPase alpha chain 1 Homo sapiens 30.9 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97169 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97169&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 44246639 164038413 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130896 N#Cc1ccc(S(=O)(=O)n2cc(CNC)cc2-c2ccc(OCC3CCOCC3)cc2F)cc1 InChI=1S/C25H26FN3O4S/c1-28-15-20-12-25(29(16-20)34(30,31)22-5-2-18(14-27)3-6-22)23-7-4-21(13-24(23)26)33-17-19-8-10-32-11-9-19/h2-7,12-13,16,19,28H,8-11,15,17H2,1H3 NARUHDCBVDTAHE-UHFFFAOYSA-N 97170 US20260001864, Compound 29 Potassium-transporting ATPase alpha chain 1 Homo sapiens 290 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97170 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97170&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 44601539 164038414 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130897 CNCc1cc(-c2ccc(OCc3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H20F3N3O3S/c1-28-12-16-9-24(30(14-16)34(31,32)20-3-2-8-29-13-20)21-6-5-19(11-23(21)27)33-15-17-10-18(25)4-7-22(17)26/h2-11,13-14,28H,12,15H2,1H3 CMSJONZDFLPKIX-UHFFFAOYSA-N 97171 US20260001864, Compound 54 Potassium-transporting ATPase alpha chain 1 Homo sapiens 17.8 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97171 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97171&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2374706 164038415 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130898 CNCc1cc(-c2ccc(OCc3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2cccc(F)c2)c1 InChI=1S/C25H20F4N2O3S/c1-30-13-16-9-25(31(14-16)35(32,33)21-4-2-3-18(26)11-21)22-7-6-20(12-24(22)29)34-15-17-10-19(27)5-8-23(17)28/h2-12,14,30H,13,15H2,1H3 NVPJXTCBDURVEC-UHFFFAOYSA-N 97172 US20260001864, Compound 79 Potassium-transporting ATPase alpha chain 1 Homo sapiens 55.3 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97172 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97172&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 261711 164038416 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130899 CNCc1cc(-c2ccc(OCC3CCC(F)(F)CC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H26F3N3O3S/c1-28-13-18-11-23(30(15-18)34(31,32)20-3-2-10-29-14-20)21-5-4-19(12-22(21)25)33-16-17-6-8-24(26,27)9-7-17/h2-5,10-12,14-15,17,28H,6-9,13,16H2,1H3 FNTKOSYAQBVEND-UHFFFAOYSA-N 97173 US20260001864, Compound 5 Potassium-transporting ATPase alpha chain 1 Homo sapiens 82.4 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97173 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97173&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 4323685 164038417 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130900 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(OCCF)c2)c1 InChI=1S/C26H30F2N2O5S/c1-29-16-20-13-26(24-6-5-22(15-25(24)28)35-18-19-7-10-33-11-8-19)30(17-20)36(31,32)23-4-2-3-21(14-23)34-12-9-27/h2-6,13-15,17,19,29H,7-12,16,18H2,1H3 YIWQRLVQMULPHL-UHFFFAOYSA-N 97174 US20260001864, Compound 30 Potassium-transporting ATPase alpha chain 1 Homo sapiens 474 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97174 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97174&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 91899624 164038418 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130901 CNCc1cc(-c2ccc(OCc3ccc(F)cc3F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H20F3N3O3S/c1-28-12-16-9-24(30(14-16)34(31,32)20-3-2-8-29-13-20)21-7-6-19(11-23(21)27)33-15-17-4-5-18(25)10-22(17)26/h2-11,13-14,28H,12,15H2,1H3 WNGMHQWBPUCGFU-UHFFFAOYSA-N 97175 US20260001864, Compound 55 Potassium-transporting ATPase alpha chain 1 Homo sapiens 8.60 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97175 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97175&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3826744 164038419 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130902 CNCc1cc(-c2ccc(OCc3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2cc(F)cc(F)c2)c1 InChI=1S/C25H19F5N2O3S/c1-31-12-15-6-25(32(13-15)36(33,34)21-9-18(27)8-19(28)10-21)22-4-3-20(11-24(22)30)35-14-16-7-17(26)2-5-23(16)29/h2-11,13,31H,12,14H2,1H3 ZWUROAZPLNLZKP-UHFFFAOYSA-N 97176 US20260001864, Compound 80 Potassium-transporting ATPase alpha chain 1 Homo sapiens 65.9 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97176 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97176&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 5303 164038420 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130903 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C23H26FN3O4S/c1-25-13-18-11-23(27(15-18)32(28,29)20-3-2-8-26-14-20)21-5-4-19(12-22(21)24)31-16-17-6-9-30-10-7-17/h2-5,8,11-12,14-15,17,25H,6-7,9-10,13,16H2,1H3 WMHXDVWOOLDERD-UHFFFAOYSA-N 97177 US20260001864, Compound 6 Potassium-transporting ATPase alpha chain 1 Homo sapiens 149 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97177 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97177&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 309279 164038421 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130904 CCCCCOc1cccc(S(=O)(=O)n2cc(CNC)cc2-c2ccc(OCC3CCOCC3)cc2F)c1 InChI=1S/C29H37FN2O5S/c1-3-4-5-13-36-24-7-6-8-26(17-24)38(33,34)32-20-23(19-31-2)16-29(32)27-10-9-25(18-28(27)30)37-21-22-11-14-35-15-12-22/h6-10,16-18,20,22,31H,3-5,11-15,19,21H2,1-2H3 NGJQSYNBCIFAOF-UHFFFAOYSA-N 97178 US20260001864, Compound 31 Potassium-transporting ATPase alpha chain 1 Homo sapiens 1211 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97178 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97178&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 386315 164038422 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130905 CNCc1cc(-c2ccc(OCc3c(F)cccc3F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H20F3N3O3S/c1-28-12-16-10-24(30(14-16)34(31,32)18-4-3-9-29-13-18)19-8-7-17(11-23(19)27)33-15-20-21(25)5-2-6-22(20)26/h2-11,13-14,28H,12,15H2,1H3 CPDBLCBBNZSEFK-UHFFFAOYSA-N 97180 US20260001864, Compound 56 Potassium-transporting ATPase alpha chain 1 Homo sapiens 13.3 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97180 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97180&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 160 164038424 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130906 CNCc1cc(-c2ccc(OCc3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2ccc(C)c(F)c2)c1 InChI=1S/C26H22F4N2O3S/c1-16-3-6-21(12-24(16)29)36(33,34)32-14-17(13-31-2)9-26(32)22-7-5-20(11-25(22)30)35-15-18-10-19(27)4-8-23(18)28/h3-12,14,31H,13,15H2,1-2H3 PNZGWFXJVVZQIO-UHFFFAOYSA-N 97181 US20260001864, Compound 81 Potassium-transporting ATPase alpha chain 1 Homo sapiens 56.6 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97181 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97181&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 326887 164038425 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130907 CNCc1cc(-c2ccc(OCC3CCCCO3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C23H26FN3O4S/c1-25-13-17-11-23(27(15-17)32(28,29)20-6-4-9-26-14-20)21-8-7-18(12-22(21)24)31-16-19-5-2-3-10-30-19/h4,6-9,11-12,14-15,19,25H,2-3,5,10,13,16H2,1H3 JGIPUDLKWQQJPK-UHFFFAOYSA-N 97182 US20260001864, Compound 7 Potassium-transporting ATPase alpha chain 1 Homo sapiens 254 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97182 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97182&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 46943517 164038426 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130908 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(OCCCOC)c2)c1 InChI=1S/C28H35FN2O6S/c1-30-18-22-15-28(26-8-7-24(17-27(26)29)37-20-21-9-13-35-14-10-21)31(19-22)38(32,33)25-6-3-5-23(16-25)36-12-4-11-34-2/h3,5-8,15-17,19,21,30H,4,9-14,18,20H2,1-2H3 ZVKFSKDBVKAVMO-UHFFFAOYSA-N 97183 US20260001864, Compound 32 Potassium-transporting ATPase alpha chain 1 Homo sapiens 822 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97183 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97183&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 49778246 164038427 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130909 CNCc1cc(-c2ccc(OCc3ccc(F)c(F)c3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H20F3N3O3S/c1-28-12-17-10-24(30(14-17)34(31,32)19-3-2-8-29-13-19)20-6-5-18(11-22(20)26)33-15-16-4-7-21(25)23(27)9-16/h2-11,13-14,28H,12,15H2,1H3 YRLUJCGZBVUCJL-UHFFFAOYSA-N 97184 US20260001864, Compound 57 Potassium-transporting ATPase alpha chain 1 Homo sapiens 46.3 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97184 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97184&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 49778835 164038428 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130910 CCCCCOc1cccc(S(=O)(=O)n2cc(CNC)cc2-c2ccc(OCc3cc(F)ccc3F)cc2F)c1 InChI=1S/C30H31F3N2O4S/c1-3-4-5-13-38-24-7-6-8-26(16-24)40(36,37)35-19-21(18-34-2)14-30(35)27-11-10-25(17-29(27)33)39-20-22-15-23(31)9-12-28(22)32/h6-12,14-17,19,34H,3-5,13,18,20H2,1-2H3 DHDXZUDTNNREGL-UHFFFAOYSA-N 97185 US20260001864, Compound 82 Potassium-transporting ATPase alpha chain 1 Homo sapiens 3659 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97185 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97185&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 49786188 164038429 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130911 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H28FN3O4S/c1-17(19-7-10-31-11-8-19)32-20-5-6-22(23(25)13-20)24-12-18(14-26-2)16-28(24)33(29,30)21-4-3-9-27-15-21/h3-6,9,12-13,15-17,19,26H,7-8,10-11,14H2,1-2H3 OAYZRBXFOJGXIP-UHFFFAOYSA-N 97186 US20260001864, Compound 8 Potassium-transporting ATPase alpha chain 1 Homo sapiens 72.1 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97186 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97186&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 49795269 164038430 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130912 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(OCC3CCC3)c2)c1 InChI=1S/C30H37FN2O5S/c1-21(24-11-13-36-14-12-24)38-26-9-10-28(29(31)17-26)30-15-23(18-32-2)19-33(30)39(34,35)27-8-4-7-25(16-27)37-20-22-5-3-6-22/h4,7-10,15-17,19,21-22,24,32H,3,5-6,11-14,18,20H2,1-2H3 VBYUNPONACKSKK-UHFFFAOYSA-N 97187 US20260001864, Compound 33 Potassium-transporting ATPase alpha chain 1 Homo sapiens 883 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97187 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97187&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 51360001 164038431 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130913 CNCc1cc(-c2ccc(OCc3cc(F)cc(F)c3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H20F3N3O3S/c1-28-12-17-9-24(30(14-17)34(31,32)21-3-2-6-29-13-21)22-5-4-20(11-23(22)27)33-15-16-7-18(25)10-19(26)8-16/h2-11,13-14,28H,12,15H2,1H3 QUEIPOYMGPZQCS-UHFFFAOYSA-N 97188 US20260001864, Compound 58 Potassium-transporting ATPase alpha chain 1 Homo sapiens 25.7 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97188 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97188&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 51360013 164038432 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130914 CNCc1cc(-c2ccc(OC(C)c3c(F)cccc3F)cc2F)n(S(=O)(=O)c2cccc(OCC3CCC3)c2)c1 InChI=1S/C31H31F3N2O4S/c1-20(31-27(32)10-5-11-28(31)33)40-24-12-13-26(29(34)16-24)30-14-22(17-35-2)18-36(30)41(37,38)25-9-4-8-23(15-25)39-19-21-6-3-7-21/h4-5,8-16,18,20-21,35H,3,6-7,17,19H2,1-2H3 UILMZDXNWAFMHD-UHFFFAOYSA-N 97189 US20260001864, Compound 83 Potassium-transporting ATPase alpha chain 1 Homo sapiens 13340 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97189 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97189&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 51360281 164038433 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130915 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cc(F)cc(F)c2)c1 InChI=1S/C25H27F3N2O4S/c1-16(18-5-7-33-8-6-18)34-21-3-4-23(24(28)13-21)25-9-17(14-29-2)15-30(25)35(31,32)22-11-19(26)10-20(27)12-22/h3-4,9-13,15-16,18,29H,5-8,14H2,1-2H3 ISJJAZLMSGPDHL-UHFFFAOYSA-N 97190 US20260001864, Compound 9 Potassium-transporting ATPase alpha chain 1 Homo sapiens 25.4 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97190 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97190&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 53299527 164038434 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130916 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(OCC3CCCC3)c2)c1 InChI=1S/C30H37FN2O5S/c1-32-18-24-15-30(28-10-9-26(17-29(28)31)38-21-23-11-13-36-14-12-23)33(19-24)39(34,35)27-8-4-7-25(16-27)37-20-22-5-2-3-6-22/h4,7-10,15-17,19,22-23,32H,2-3,5-6,11-14,18,20-21H2,1H3 DPBUZRVDQRKNTD-UHFFFAOYSA-N 97191 US20260001864, Compound 34 Potassium-transporting ATPase alpha chain 1 Homo sapiens 285 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97191 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97191&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 108144 164038435 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130917 CNCc1cc(-c2ccc(OCc3ccccc3OC(F)F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H22F3N3O4S/c1-29-13-17-11-23(31(15-17)36(32,33)20-6-4-10-30-14-20)21-9-8-19(12-22(21)26)34-16-18-5-2-3-7-24(18)35-25(27)28/h2-12,14-15,25,29H,13,16H2,1H3 FAPBLSKAPVZFQY-UHFFFAOYSA-N 97192 US20260001864, Compound 59 Potassium-transporting ATPase alpha chain 1 Homo sapiens 41.3 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97192 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97192&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 53382850 164038436 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130918 CNCc1cc(-c2ccc(OCc3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2cccc(OCC3CCCC3)c2)c1 InChI=1S/C31H31F3N2O4S/c1-35-17-22-13-31(28-11-10-26(16-30(28)34)40-20-23-14-24(32)9-12-29(23)33)36(18-22)41(37,38)27-8-4-7-25(15-27)39-19-21-5-2-3-6-21/h4,7-16,18,21,35H,2-3,5-6,17,19-20H2,1H3 UNHVQGZXOXUHNZ-UHFFFAOYSA-N 97193 US20260001864, Compound 84 Potassium-transporting ATPase alpha chain 1 Homo sapiens 109 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97193 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97193&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 53385430 164038437 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130919 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(C(F)(F)F)c2)c1 InChI=1S/C26H28F4N2O4S/c1-17(19-8-10-35-11-9-19)36-21-6-7-23(24(27)14-21)25-12-18(15-31-2)16-32(25)37(33,34)22-5-3-4-20(13-22)26(28,29)30/h3-7,12-14,16-17,19,31H,8-11,15H2,1-2H3 KDXJITZETBUICD-UHFFFAOYSA-N 97194 US20260001864, Compound 10 Potassium-transporting ATPase alpha chain 1 Homo sapiens 55.3 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=97194 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=97194&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 53385437 164038438 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130920 CNCc1cc(-c2ccc(OCC3CCCCC3)cc2F)n(S(=O)(=O)c2cccc(OCCF)c2)c1 InChI=1S/C27H32F2N2O4S/c1-30-17-21-14-27(25-11-10-23(16-26(25)29)35-19-20-6-3-2-4-7-20)31(18-21)36(32,33)24-9-5-8-22(15-24)34-13-12-28/h5,8-11,14-16,18,20,30H,2-4,6-7,12-13,17,19H2,1H3 NMYGURNHHQZCMD-UHFFFAOYSA-N 100196 US20260001864, Compound 35 Potassium-transporting ATPase alpha chain 1 Homo sapiens 8649 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100196 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100196&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 657407 252663283 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130921 CNCc1cc(-c2ccc(OCc3ccccc3OC(F)(F)F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H21F4N3O4S/c1-30-13-17-11-23(32(15-17)37(33,34)20-6-4-10-31-14-20)21-9-8-19(12-22(21)26)35-16-18-5-2-3-7-24(18)36-25(27,28)29/h2-12,14-15,30H,13,16H2,1H3 GMWYYHYYRLXAGQ-UHFFFAOYSA-N 100197 US20260001864, Compound 60 Potassium-transporting ATPase alpha chain 1 Homo sapiens 186 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100197 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100197&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 659153 252663284 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130922 CNCc1cc(-c2ccc(OC(C)c3c(F)cccc3F)cc2F)n(S(=O)(=O)c2cccc(OCC3CCCC3)c2)c1 InChI=1S/C32H33F3N2O4S/c1-21(32-28(33)11-6-12-29(32)34)41-25-13-14-27(30(35)17-25)31-15-23(18-36-2)19-37(31)42(38,39)26-10-5-9-24(16-26)40-20-22-7-3-4-8-22/h5-6,9-17,19,21-22,36H,3-4,7-8,18,20H2,1-2H3 UAUBFHMIYKBPSF-UHFFFAOYSA-N 100198 US20260001864, Compound 85 Potassium-transporting ATPase alpha chain 1 Homo sapiens 9781 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100198 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100198&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 91899630 252663285 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130923 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2ccc(C)c(F)c2)c1 InChI=1S/C26H30F2N2O4S/c1-17-4-6-22(14-24(17)27)35(31,32)30-16-19(15-29-3)12-26(30)23-7-5-21(13-25(23)28)34-18(2)20-8-10-33-11-9-20/h4-7,12-14,16,18,20,29H,8-11,15H2,1-3H3 CGOCAMMYGYMZDQ-UHFFFAOYSA-N 100199 US20260001864, Compound 11 Potassium-transporting ATPase alpha chain 1 Homo sapiens 65.2 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100199 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100199&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 661985 252663286 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130924 CCCCCOc1cccc(S(=O)(=O)n2cc(CNC)cc2-c2ccc(OCC3CCCCC3)cc2F)c1 InChI=1S/C30H39FN2O4S/c1-3-4-8-16-36-25-12-9-13-27(18-25)38(34,35)33-21-24(20-32-2)17-30(33)28-15-14-26(19-29(28)31)37-22-23-10-6-5-7-11-23/h9,12-15,17-19,21,23,32H,3-8,10-11,16,20,22H2,1-2H3 XYTWXIBVCCWFGJ-UHFFFAOYSA-N 100200 US20260001864, Compound 36 Potassium-transporting ATPase alpha chain 1 Homo sapiens 2272 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100200 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100200&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 1307598 252663287 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130925 CNCc1cc(-c2ccc(OCc3ccc(OC(F)F)cc3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H22F3N3O4S/c1-29-13-18-11-24(31(15-18)36(32,33)21-3-2-10-30-14-21)22-9-8-20(12-23(22)26)34-16-17-4-6-19(7-5-17)35-25(27)28/h2-12,14-15,25,29H,13,16H2,1H3 OYBUDWBFXRHKEI-UHFFFAOYSA-N 100201 US20260001864, Compound 61 Potassium-transporting ATPase alpha chain 1 Homo sapiens 51.3 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100201 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100201&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 5310556 252663288 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130926 CNCc1cc(-c2ccc(OCc3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2cccc(OCCOC)c2)c1 InChI=1S/C28H27F3N2O5S/c1-32-16-19-12-28(33(17-19)39(34,35)24-5-3-4-22(14-24)37-11-10-36-2)25-8-7-23(15-27(25)31)38-18-20-13-21(29)6-9-26(20)30/h3-9,12-15,17,32H,10-11,16,18H2,1-2H3 WSAFEGGGDHSMGV-UHFFFAOYSA-N 100202 US20260001864, Compound 86 Potassium-transporting ATPase alpha chain 1 Homo sapiens 34.4 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100202 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100202&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2536570 252663289 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130927 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cc(F)ccc2F)c1 InChI=1S/C25H27F3N2O4S/c1-16(18-7-9-33-10-8-18)34-20-4-5-21(23(28)13-20)24-11-17(14-29-2)15-30(24)35(31,32)25-12-19(26)3-6-22(25)27/h3-6,11-13,15-16,18,29H,7-10,14H2,1-2H3 PCYUCOVMDUZCII-UHFFFAOYSA-N 100203 US20260001864, Compound 12 Potassium-transporting ATPase alpha chain 1 Homo sapiens 138 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100203 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100203&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2318527 252663290 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130928 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(OCCCOC)c2)c1 InChI=1S/C29H37FN2O6S/c1-21(23-10-14-36-15-11-23)38-25-8-9-27(28(30)18-25)29-16-22(19-31-2)20-32(29)39(33,34)26-7-4-6-24(17-26)37-13-5-12-35-3/h4,6-9,16-18,20-21,23,31H,5,10-15,19H2,1-3H3 LCWXHPYRBHPVCO-UHFFFAOYSA-N 100204 US20260001864, Compound 37 Potassium-transporting ATPase alpha chain 1 Homo sapiens 157 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100204 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100204&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 1479487 252663291 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130929 CNCc1cc(-c2ccc(OCc3cccc4ccccc34)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C28H24FN3O3S/c1-30-16-20-14-28(32(18-20)36(33,34)24-9-5-13-31-17-24)26-12-11-23(15-27(26)29)35-19-22-8-4-7-21-6-2-3-10-25(21)22/h2-15,17-18,30H,16,19H2,1H3 LXMUVUVPNHULIA-UHFFFAOYSA-N 100206 US20260001864, Compound 62 Potassium-transporting ATPase alpha chain 1 Homo sapiens 35.9 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100206 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100206&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 704682 252663293 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130930 CNCc1cc(-c2ccc(OCc3ccccc3OC)cc2F)n(S(=O)(=O)c2cccc(OCCOC)c2)c1 InChI=1S/C29H31FN2O6S/c1-31-18-21-15-28(32(19-21)39(33,34)25-9-6-8-23(16-25)37-14-13-35-2)26-12-11-24(17-27(26)30)38-20-22-7-4-5-10-29(22)36-3/h4-12,15-17,19,31H,13-14,18,20H2,1-3H3 XPOVWYDZRBZNMV-UHFFFAOYSA-N 100208 US20260001864, Compound 87 Potassium-transporting ATPase alpha chain 1 Homo sapiens 43.4 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100208 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100208&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 5338376 252663295 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130931 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(C#N)c2)c1 InChI=1S/C26H28FN3O4S/c1-18(21-8-10-33-11-9-21)34-22-6-7-24(25(27)14-22)26-13-20(16-29-2)17-30(26)35(31,32)23-5-3-4-19(12-23)15-28/h3-7,12-14,17-18,21,29H,8-11,16H2,1-2H3 IVSKTDBBPZUKCP-UHFFFAOYSA-N 100209 US20260001864, Compound 13 Potassium-transporting ATPase alpha chain 1 Homo sapiens 114 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100209 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100209&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 767684 252663296 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130932 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(OCCCCOC)c2)c1 InChI=1S/C30H39FN2O6S/c1-22(24-11-15-37-16-12-24)39-26-9-10-28(29(31)19-26)30-17-23(20-32-2)21-33(30)40(34,35)27-8-6-7-25(18-27)38-14-5-4-13-36-3/h6-10,17-19,21-22,24,32H,4-5,11-16,20H2,1-3H3 VLALCBXEYQZHIM-UHFFFAOYSA-N 100210 US20260001864, Compound 38 Potassium-transporting ATPase alpha chain 1 Homo sapiens 199 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100210 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100210&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 4198759 252663297 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130933 CNCc1cc(-c2ccc(OCc3cccc4ccccc34)cc2F)n(S(=O)(=O)c2cccc(C#N)c2)c1 InChI=1S/C30H24FN3O3S/c1-33-18-22-15-30(34(19-22)38(35,36)26-10-4-6-21(14-26)17-32)28-13-12-25(16-29(28)31)37-20-24-9-5-8-23-7-2-3-11-27(23)24/h2-16,19,33H,18,20H2,1H3 XEHYEVPDFLLLDX-UHFFFAOYSA-N 100211 US20260001864, Compound 63 Potassium-transporting ATPase alpha chain 1 Homo sapiens 1057 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100211 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100211&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2514699 252663298 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130934 CNCc1cc(-c2ccc(OC(C)c3c(F)cccc3F)cc2F)n(S(=O)(=O)c2cccc(OCCCOC)c2)c1 InChI=1S/C30H31F3N2O5S/c1-20(30-26(31)9-5-10-27(30)32)40-23-11-12-25(28(33)17-23)29-15-21(18-34-2)19-35(29)41(36,37)24-8-4-7-22(16-24)39-14-6-13-38-3/h4-5,7-12,15-17,19-20,34H,6,13-14,18H2,1-3H3 LTOXFIVUCYAMCQ-UHFFFAOYSA-N 100212 US20260001864, Compound 88 Potassium-transporting ATPase alpha chain 1 Homo sapiens 450 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100212 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100212&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2315545 252663299 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130935 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(OCCOC)c2)c1 InChI=1S/C28H35FN2O6S/c1-20(22-9-11-35-12-10-22)37-24-7-8-26(27(29)17-24)28-15-21(18-30-2)19-31(28)38(32,33)25-6-4-5-23(16-25)36-14-13-34-3/h4-8,15-17,19-20,22,30H,9-14,18H2,1-3H3 LWDDTFAUNYIBNI-UHFFFAOYSA-N 100213 US20260001864, Compound 14 Potassium-transporting ATPase alpha chain 1 Homo sapiens 443 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100213 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100213&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2461136 252663300 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130936 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(C(F)(F)F)c2)c1 InChI=1S/C25H26F4N2O4S/c1-30-14-18-11-24(22-6-5-20(13-23(22)26)35-16-17-7-9-34-10-8-17)31(15-18)36(32,33)21-4-2-3-19(12-21)25(27,28)29/h2-6,11-13,15,17,30H,7-10,14,16H2,1H3 UKFRVOWCNMCKCG-UHFFFAOYSA-N 100214 US20260001864, Compound 39 Potassium-transporting ATPase alpha chain 1 Homo sapiens 34.6 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100214 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100214&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2087148 252663301 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130937 CNCc1cc(-c2ccc(OCc3ccc(C(=O)O)cc3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H22FN3O5S/c1-27-13-18-11-24(29(15-18)35(32,33)21-3-2-10-28-14-21)22-9-8-20(12-23(22)26)34-16-17-4-6-19(7-5-17)25(30)31/h2-12,14-15,27H,13,16H2,1H3,(H,30,31) QUEGVBSCKDLOFL-UHFFFAOYSA-N 100215 US20260001864, Compound 64 Potassium-transporting ATPase alpha chain 1 Homo sapiens 164 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100215 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100215&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16187732 252663302 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130938 CNCc1cc(-c2ccc(OC(C)c3cc(F)cc(F)c3)cc2F)n(S(=O)(=O)c2cccc(OCCCOC)c2)c1 InChI=1S/C30H31F3N2O5S/c1-20(22-13-23(31)15-24(32)14-22)40-26-8-9-28(29(33)17-26)30-12-21(18-34-2)19-35(30)41(36,37)27-7-4-6-25(16-27)39-11-5-10-38-3/h4,6-9,12-17,19-20,34H,5,10-11,18H2,1-3H3 RZMHXXRBCUPPRD-UHFFFAOYSA-N 100216 US20260001864, Compound 89 Potassium-transporting ATPase alpha chain 1 Homo sapiens 1333 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100216 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100216&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16188788 252663303 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130939 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(OC)c2)c1 InChI=1S/C26H31FN2O5S/c1-18(20-9-11-33-12-10-20)34-22-7-8-24(25(27)15-22)26-13-19(16-28-2)17-29(26)35(30,31)23-6-4-5-21(14-23)32-3/h4-8,13-15,17-18,20,28H,9-12,16H2,1-3H3 GKNXEODXJAVOBC-UHFFFAOYSA-N 100217 US20260001864, Compound 15 Potassium-transporting ATPase alpha chain 1 Homo sapiens 83.9 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100217 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100217&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 534484 252663304 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130940 CNCc1cc(-c2ccc(OC)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C18H18FN3O3S/c1-20-10-13-8-18(16-6-5-14(25-2)9-17(16)19)22(12-13)26(23,24)15-4-3-7-21-11-15/h3-9,11-12,20H,10H2,1-2H3 SIOLFASLETVMET-UHFFFAOYSA-N 100218 US20260001864, Compound 40 Potassium-transporting ATPase alpha chain 1 Homo sapiens 123 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100218 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100218&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3248530 252663305 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130941 CNCc1cc(-c2ccc(OC(C)c3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H22F3N3O3S/c1-16(22-11-18(26)5-8-23(22)27)34-19-6-7-21(24(28)12-19)25-10-17(13-29-2)15-31(25)35(32,33)20-4-3-9-30-14-20/h3-12,14-16,29H,13H2,1-2H3 IAIZZRXUDVRWRI-UHFFFAOYSA-N 100219 US20260001864, Compound 65 Potassium-transporting ATPase alpha chain 1 Homo sapiens 80.5 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100219 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100219&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16189691 252663306 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130942 CNCc1cc(-c2ccc(OCc3ccc4ccccc4c3)cc2F)n(S(=O)(=O)c2cccc(OCCCCOC)c2)c1 InChI=1S/C34H35FN2O5S/c1-36-22-26-19-34(37(23-26)43(38,39)31-11-7-10-29(20-31)41-17-6-5-16-40-2)32-15-14-30(21-33(32)35)42-24-25-12-13-27-8-3-4-9-28(27)18-25/h3-4,7-15,18-21,23,36H,5-6,16-17,22,24H2,1-2H3 MMBKNWSGPNMMAY-UHFFFAOYSA-N 100220 US20260001864, Compound 90 Potassium-transporting ATPase alpha chain 1 Homo sapiens 2692 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100220 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100220&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16190915 252663307 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130943 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2c(F)cccc2F)c1 InChI=1S/C25H27F3N2O4S/c1-16(18-8-10-33-11-9-18)34-19-6-7-20(23(28)13-19)24-12-17(14-29-2)15-30(24)35(31,32)25-21(26)4-3-5-22(25)27/h3-7,12-13,15-16,18,29H,8-11,14H2,1-2H3 IQQUANYUJVCGET-UHFFFAOYSA-N 100221 US20260001864, Compound 16 Potassium-transporting ATPase alpha chain 1 Homo sapiens 253 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100221 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100221&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16191094 252663308 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130944 CCOc1ccc(-c2cc(CNC)cn2S(=O)(=O)c2cccnc2)c(F)c1 InChI=1S/C19H20FN3O3S/c1-3-26-15-6-7-17(18(20)10-15)19-9-14(11-21-2)13-23(19)27(24,25)16-5-4-8-22-12-16/h4-10,12-13,21H,3,11H2,1-2H3 HRSMVNKENHBOKZ-UHFFFAOYSA-N 100222 US20260001864, Compound 41 Potassium-transporting ATPase alpha chain 1 Homo sapiens 567 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100222 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100222&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16191178 252663309 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130945 CNCc1cc(-c2ccc(O[C@@H](C)c3c(Cl)ccc(F)c3Cl)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H21Cl2F2N3O3S/c1-15(24-20(26)7-8-21(28)25(24)27)35-17-5-6-19(22(29)11-17)23-10-16(12-30-2)14-32(23)36(33,34)18-4-3-9-31-13-18/h3-11,13-15,30H,12H2,1-2H3 FNMQVDPHZQVISS-UHFFFAOYSA-N 100223 US20260001864, Compound 66 Potassium-transporting ATPase alpha chain 1 Homo sapiens 485 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100223 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100223&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 1080609 252663310 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130946 CNCc1cc(-c2ccc(OC(C)c3c(F)cccc3F)cc2F)n(S(=O)(=O)c2cccc(OCCCCOC)c2)c1 InChI=1S/C31H33F3N2O5S/c1-21(31-27(32)10-7-11-28(31)33)41-24-12-13-26(29(34)18-24)30-16-22(19-35-2)20-36(30)42(37,38)25-9-6-8-23(17-25)40-15-5-4-14-39-3/h6-13,16-18,20-21,35H,4-5,14-15,19H2,1-3H3 VQIRLCXGNDZONL-UHFFFAOYSA-N 100224 US20260001864, Compound 91 Potassium-transporting ATPase alpha chain 1 Homo sapiens 693 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100224 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100224&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 1126240 252663311 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130947 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2ccc(F)cc2F)c1 InChI=1S/C25H27F3N2O4S/c1-16(18-7-9-33-10-8-18)34-20-4-5-21(22(27)13-20)24-11-17(14-29-2)15-30(24)35(31,32)25-6-3-19(26)12-23(25)28/h3-6,11-13,15-16,18,29H,7-10,14H2,1-2H3 JSIIALMYKIFWKK-UHFFFAOYSA-N 100225 US20260001864, Compound 17 Potassium-transporting ATPase alpha chain 1 Homo sapiens 265 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100225 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100225&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 9689367 242053879 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130948 CNCc1cc(-c2ccc(OCC(F)F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C19H18F3N3O3S/c1-23-9-13-7-18(16-5-4-14(8-17(16)20)28-12-19(21)22)25(11-13)29(26,27)15-3-2-6-24-10-15/h2-8,10-11,19,23H,9,12H2,1H3 BNPZEKSMMYCYPA-UHFFFAOYSA-N 100226 US20260001864, Compound 42 Potassium-transporting ATPase alpha chain 1 Homo sapiens 401 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100226 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100226&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 2307153 252663312 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130949 CNCc1cc(-c2ccc(OC(C)c3c(F)cccc3F)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H22F3N3O3S/c1-16(25-21(26)6-3-7-22(25)27)34-18-8-9-20(23(28)12-18)24-11-17(13-29-2)15-31(24)35(32,33)19-5-4-10-30-14-19/h3-12,14-16,29H,13H2,1-2H3 KHMGYYNBBREMQG-UHFFFAOYSA-N 100227 US20260001864, Compound 67 Potassium-transporting ATPase alpha chain 1 Homo sapiens 41.0 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100227 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100227&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 73307486 252663313 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130950 CNCc1cc(-c2ccc(OC(C)c3cc(F)cc(F)c3)cc2F)n(S(=O)(=O)c2cccc(OCCCCOC)c2)c1 InChI=1S/C31H33F3N2O5S/c1-21(23-14-24(32)16-25(33)15-23)41-27-9-10-29(30(34)18-27)31-13-22(19-35-2)20-36(31)42(37,38)28-8-6-7-26(17-28)40-12-5-4-11-39-3/h6-10,13-18,20-21,35H,4-5,11-12,19H2,1-3H3 XNWYMSDWBZAUCU-UHFFFAOYSA-N 100228 US20260001864, Compound 92 Potassium-transporting ATPase alpha chain 1 Homo sapiens 1906 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100228 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100228&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 931812 252663314 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130951 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2ccc(C#N)cc2)c1 InChI=1S/C26H28FN3O4S/c1-18(21-9-11-33-12-10-21)34-22-5-8-24(25(27)14-22)26-13-20(16-29-2)17-30(26)35(31,32)23-6-3-19(15-28)4-7-23/h3-8,13-14,17-18,21,29H,9-12,16H2,1-2H3 YHXVBCGXTOPIHB-UHFFFAOYSA-N 100229 US20260001864, Compound 18 Potassium-transporting ATPase alpha chain 1 Homo sapiens 262 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100229 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100229&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3223618 252663315 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130952 CNCc1cc(-c2ccc(OCCCOC)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C21H24FN3O4S/c1-23-13-16-11-21(25(15-16)30(26,27)18-5-3-8-24-14-18)19-7-6-17(12-20(19)22)29-10-4-9-28-2/h3,5-8,11-12,14-15,23H,4,9-10,13H2,1-2H3 HFYHRBNPACHIHL-UHFFFAOYSA-N 100230 US20260001864, Compound 43 Potassium-transporting ATPase alpha chain 1 Homo sapiens 482 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100230 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100230&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 5349700 252663316 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130953 CNCc1cc(-c2ccc(OC(C)c3cc(F)cc(F)c3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H22F3N3O3S/c1-16(18-9-19(26)11-20(27)10-18)34-21-5-6-23(24(28)12-21)25-8-17(13-29-2)15-31(25)35(32,33)22-4-3-7-30-14-22/h3-12,14-16,29H,13H2,1-2H3 MEBFOPMZHMESEU-UHFFFAOYSA-N 100231 US20260001864, Compound 68 Potassium-transporting ATPase alpha chain 1 Homo sapiens 41.4 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100231 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100231&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16405308 242053880 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130954 CNCc1cc(-c2ccc(OCc3cccc4c3OCO4)cc2F)n(S(=O)(=O)c2cccc(OCCCCOC)c2)c1 InChI=1S/C31H33FN2O7S/c1-33-18-22-15-29(34(19-22)42(35,36)26-9-6-8-24(16-26)38-14-4-3-13-37-2)27-12-11-25(17-28(27)32)39-20-23-7-5-10-30-31(23)41-21-40-30/h5-12,15-17,19,33H,3-4,13-14,18,20-21H2,1-2H3 XTOHMSCWGGDGEQ-UHFFFAOYSA-N 100232 US20260001864, Compound 93 Potassium-transporting ATPase alpha chain 1 Homo sapiens 12372 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100232 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100232&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3813473 252663317 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130955 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(F)c2)c1 InChI=1S/C25H28F2N2O4S/c1-17(19-8-10-32-11-9-19)33-21-6-7-23(24(27)14-21)25-12-18(15-28-2)16-29(25)34(30,31)22-5-3-4-20(26)13-22/h3-7,12-14,16-17,19,28H,8-11,15H2,1-2H3 XLAQXQOWRNKHSY-UHFFFAOYSA-N 100233 US20260001864, Compound 19 Potassium-transporting ATPase alpha chain 1 Homo sapiens 233 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100233 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100233&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24747936 252663318 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130956 CNCc1cc(-c2ccc(OCC(C)C)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C21H24FN3O3S/c1-15(2)14-28-17-6-7-19(20(22)10-17)21-9-16(11-23-3)13-25(21)29(26,27)18-5-4-8-24-12-18/h4-10,12-13,15,23H,11,14H2,1-3H3 LEGCISQDUPHIRF-UHFFFAOYSA-N 100234 US20260001864, Compound 44 Potassium-transporting ATPase alpha chain 1 Homo sapiens 500 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100234 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100234&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 1475476 252663319 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130957 CNCc1cc(-c2ccc(OC(C)c3c(F)cccc3F)cc2F)n(S(=O)(=O)c2cccc(C#N)c2)c1 InChI=1S/C27H22F3N3O3S/c1-17(27-23(28)7-4-8-24(27)29)36-20-9-10-22(25(30)13-20)26-12-19(15-32-2)16-33(26)37(34,35)21-6-3-5-18(11-21)14-31/h3-13,16-17,32H,15H2,1-2H3 WBUKTSZEOMVYJK-UHFFFAOYSA-N 100235 US20260001864, Compound 69 Potassium-transporting ATPase alpha chain 1 Homo sapiens 114 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100235 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100235&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 4551824 252663320 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130958 CNCc1cc(-c2ccc(OCc3cccc4c3OCO4)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H22FN3O5S/c1-27-12-17-10-23(29(14-17)35(30,31)20-5-3-9-28-13-20)21-8-7-19(11-22(21)26)32-15-18-4-2-6-24-25(18)34-16-33-24/h2-11,13-14,27H,12,15-16H2,1H3 CBKLRQPBZBANHB-UHFFFAOYSA-N 100236 US20260001864, Compound 94 Potassium-transporting ATPase alpha chain 1 Homo sapiens 48.4 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100236 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100236&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24789546 252663321 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130959 CNCc1cc(-c2ccc(OC(C)C3CCCCC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H30FN3O3S/c1-18(20-7-4-3-5-8-20)32-21-10-11-23(24(26)14-21)25-13-19(15-27-2)17-29(25)33(30,31)22-9-6-12-28-16-22/h6,9-14,16-18,20,27H,3-5,7-8,15H2,1-2H3 KAJYLTOJAVJYQP-UHFFFAOYSA-N 100237 US20260001864, Compound 20 Potassium-transporting ATPase alpha chain 1 Homo sapiens 294 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100237 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100237&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24789931 252663322 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130960 CNCc1cc(-c2ccc(OCC(C)(C)C)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C22H26FN3O3S/c1-22(2,3)15-29-17-7-8-19(20(23)11-17)21-10-16(12-24-4)14-26(21)30(27,28)18-6-5-9-25-13-18/h5-11,13-14,24H,12,15H2,1-4H3 JYQQIJXXKRUYKV-UHFFFAOYSA-N 100238 US20260001864, Compound 45 Potassium-transporting ATPase alpha chain 1 Homo sapiens 204 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100238 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100238&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 20919863 252663323 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130961 CNCc1cc(-c2ccc(OC(C)c3cc(F)cc(F)c3)cc2F)n(S(=O)(=O)c2cccc(C#N)c2)c1 InChI=1S/C27H22F3N3O3S/c1-17(20-10-21(28)12-22(29)11-20)36-23-6-7-25(26(30)13-23)27-9-19(15-32-2)16-33(27)37(34,35)24-5-3-4-18(8-24)14-31/h3-13,16-17,32H,15H2,1-2H3 TYASUMSGMKTZNS-UHFFFAOYSA-N 100239 US20260001864, Compound 70 Potassium-transporting ATPase alpha chain 1 Homo sapiens 88.1 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100239 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100239&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 20919872 252663324 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130962 CNCc1cc(-c2ccc(OCc3cccc4c3OCO4)cc2F)n(S(=O)(=O)c2cccc(C#N)c2)c1 InChI=1S/C27H22FN3O5S/c1-30-14-19-11-25(31(15-19)37(32,33)22-6-2-4-18(10-22)13-29)23-9-8-21(12-24(23)28)34-16-20-5-3-7-26-27(20)36-17-35-26/h2-12,15,30H,14,16-17H2,1H3 DEXMYKTUBCQWQZ-UHFFFAOYSA-N 100240 US20260001864, Compound 95 Potassium-transporting ATPase alpha chain 1 Homo sapiens 9.50 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100240 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100240&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 20919878 252663325 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130963 CNCc1cc(-c2ccc(OCC3CCNCC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C23H27FN4O3S/c1-25-13-18-11-23(28(15-18)32(29,30)20-3-2-8-27-14-20)21-5-4-19(12-22(21)24)31-16-17-6-9-26-10-7-17/h2-5,8,11-12,14-15,17,25-26H,6-7,9-10,13,16H2,1H3 HKKZEQJINPSMOB-UHFFFAOYSA-N 100241 US20260001864, Compound 21 Potassium-transporting ATPase alpha chain 1 Homo sapiens 2787 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100241 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100241&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24790171 252663326 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130964 CCNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H28FN3O4S/c1-2-26-14-19-12-24(28(16-19)33(29,30)21-4-3-9-27-15-21)22-6-5-20(13-23(22)25)32-17-18-7-10-31-11-8-18/h3-6,9,12-13,15-16,18,26H,2,7-8,10-11,14,17H2,1H3 PPVPKEBKSLVLPZ-UHFFFAOYSA-N 100242 US20260001864, Compound 46 Potassium-transporting ATPase alpha chain 1 Homo sapiens 639 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100242 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100242&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 20893416 252663327 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130965 CNCc1cc(-c2ccc(OC(C)c3cc(F)cc(F)c3)cc2F)n(S(=O)(=O)c2cccc(OCC3CC3)c2)c1 InChI=1S/C30H29F3N2O4S/c1-19(22-11-23(31)13-24(32)12-22)39-26-8-9-28(29(33)15-26)30-10-21(16-34-2)17-35(30)40(36,37)27-5-3-4-25(14-27)38-18-20-6-7-20/h3-5,8-15,17,19-20,34H,6-7,16,18H2,1-2H3 UWCFDAKAHKKFIQ-UHFFFAOYSA-N 100243 US20260001864, Compound 71 Potassium-transporting ATPase alpha chain 1 Homo sapiens 496 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100243 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100243&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3230696 252663328 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130966 CNCc1cc(-c2ccc(OCc3cccc4c3OCCO4)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C26H24FN3O5S/c1-28-14-18-12-24(30(16-18)36(31,32)21-5-3-9-29-15-21)22-8-7-20(13-23(22)27)35-17-19-4-2-6-25-26(19)34-11-10-33-25/h2-9,12-13,15-16,28H,10-11,14,17H2,1H3 IGJIZHIWZQHYTG-UHFFFAOYSA-N 100244 US20260001864, Compound 96 Potassium-transporting ATPase alpha chain 1 Homo sapiens 51.1 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100244 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100244&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24793990 252663329 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130967 CNCc1cc(-c2ccc(OCC3CCN(C)CC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H29FN4O3S/c1-26-14-19-12-24(29(16-19)33(30,31)21-4-3-9-27-15-21)22-6-5-20(13-23(22)25)32-17-18-7-10-28(2)11-8-18/h3-6,9,12-13,15-16,18,26H,7-8,10-11,14,17H2,1-2H3 GFCHYEUQJALOSD-UHFFFAOYSA-N 100245 US20260001864, Compound 22 Potassium-transporting ATPase alpha chain 1 Homo sapiens 458 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100245 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100245&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16406758 252663330 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130968 CNCc1cc(-c2ccc(OC(C)C3CCOCC3)c(F)c2)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C24H28FN3O4S/c1-17(19-7-10-31-11-8-19)32-24-6-5-20(13-22(24)25)23-12-18(14-26-2)16-28(23)33(29,30)21-4-3-9-27-15-21/h3-6,9,12-13,15-17,19,26H,7-8,10-11,14H2,1-2H3 FZPQVJPAJSBPIS-UHFFFAOYSA-N 100246 US20260001864, Compound 47 Potassium-transporting ATPase alpha chain 1 Homo sapiens 247 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100246 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100246&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24819246 252663331 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130969 CNCc1cc(-c2ccc(OC(C)c3c(F)cccc3F)cc2F)n(S(=O)(=O)c2cccc(OCC3CC3)c2)c1 InChI=1S/C30H29F3N2O4S/c1-19(30-26(31)7-4-8-27(30)32)39-23-11-12-25(28(33)15-23)29-13-21(16-34-2)17-35(29)40(36,37)24-6-3-5-22(14-24)38-18-20-9-10-20/h3-8,11-15,17,19-20,34H,9-10,16,18H2,1-2H3 RKCTYFQHSRVIIP-UHFFFAOYSA-N 100247 US20260001864, Compound 72 Potassium-transporting ATPase alpha chain 1 Homo sapiens 342 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100247 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100247&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24979797 252663332 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130970 CNCc1cc(-c2ccc(OCc3cccc4c3OCCO4)cc2F)n(S(=O)(=O)c2cccc(C#N)c2)c1 InChI=1S/C28H24FN3O5S/c1-31-16-20-13-26(32(17-20)38(33,34)23-6-2-4-19(12-23)15-30)24-9-8-22(14-25(24)29)37-18-21-5-3-7-27-28(21)36-11-10-35-27/h2-9,12-14,17,31H,10-11,16,18H2,1H3 JYHDWXYFXITWFU-UHFFFAOYSA-N 100248 US20260001864, Compound 97 Potassium-transporting ATPase alpha chain 1 Homo sapiens 11.9 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100248 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100248&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24980515 252663333 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130971 CNCc1cc(-c2ccc(OCC3CCN(C(C)=O)CC3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H29FN4O4S/c1-18(31)29-10-7-19(8-11-29)17-34-21-5-6-23(24(26)13-21)25-12-20(14-27-2)16-30(25)35(32,33)22-4-3-9-28-15-22/h3-6,9,12-13,15-16,19,27H,7-8,10-11,14,17H2,1-2H3 LVCNKVJGUANMPJ-UHFFFAOYSA-N 100249 US20260001864, Compound 23 Potassium-transporting ATPase alpha chain 1 Homo sapiens 908 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100249 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100249&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24980640 252663334 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130972 CNCc1cn(S(=O)(=O)c2cccnc2)c(-c2ccc(OCC3CC3)cc2F)c1OC InChI=1S/C22H24FN3O4S/c1-24-11-16-13-26(31(27,28)18-4-3-9-25-12-18)21(22(16)29-2)19-8-7-17(10-20(19)23)30-14-15-5-6-15/h3-4,7-10,12-13,15,24H,5-6,11,14H2,1-2H3 VPSQNTJVXOGEIO-UHFFFAOYSA-N 100250 US20260001864, Compound 48 Potassium-transporting ATPase alpha chain 1 Homo sapiens 36.0 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100250 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100250&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24981266 252663335 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130973 CNCc1cc(-c2ccc(OCc3ccc(C)cc3C)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C26H26FN3O3S/c1-18-6-7-21(19(2)11-18)17-33-22-8-9-24(25(27)13-22)26-12-20(14-28-3)16-30(26)34(31,32)23-5-4-10-29-15-23/h4-13,15-16,28H,14,17H2,1-3H3 ZIHPSBSPMJNUGF-UHFFFAOYSA-N 100251 US20260001864, Compound 73 Potassium-transporting ATPase alpha chain 1 Homo sapiens 209 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100251 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100251&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 16211584 252663336 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130974 CNCc1cc(-c2ccc(OCc3cc(F)ccc3F)cc2F)n(S(=O)(=O)c2cccc(C(F)(F)F)c2)c1 InChI=1S/C26H20F6N2O3S/c1-33-13-16-9-25(34(14-16)38(35,36)21-4-2-3-18(11-21)26(30,31)32)22-7-6-20(12-24(22)29)37-15-17-10-19(27)5-8-23(17)28/h2-12,14,33H,13,15H2,1H3 DUVNKEVTGQHKIF-UHFFFAOYSA-N 100252 US20260001864, Compound 98 Potassium-transporting ATPase alpha chain 1 Homo sapiens 485 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100252 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100252&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 8096034 252663337 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130975 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(F)c2)c1 InChI=1S/C24H26F2N2O4S/c1-27-14-18-11-24(28(15-18)33(29,30)21-4-2-3-19(25)12-21)22-6-5-20(13-23(22)26)32-16-17-7-9-31-10-8-17/h2-6,11-13,15,17,27H,7-10,14,16H2,1H3 DWEPIRIVPSDNCP-UHFFFAOYSA-N 100253 US20260001864, Compound 24 Potassium-transporting ATPase alpha chain 1 Homo sapiens 136 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100253 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100253&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 4969288 252663338 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130976 CNCc1cc(-c2ccc(OC[C@H]3CO3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C20H20FN3O4S/c1-22-9-14-7-20(24(11-14)29(25,26)17-3-2-6-23-10-17)18-5-4-15(8-19(18)21)27-12-16-13-28-16/h2-8,10-11,16,22H,9,12-13H2,1H3 USUXVBSQBVOUOQ-UHFFFAOYSA-N 100254 US20260001864, Compound 49 Potassium-transporting ATPase alpha chain 1 Homo sapiens 146 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100254 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100254&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 44143862 252663339 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130977 CNCc1cc(-c2ccc(OCc3ccncc3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C23H21FN4O3S/c1-25-13-18-11-23(28(15-18)32(29,30)20-3-2-8-27-14-20)21-5-4-19(12-22(21)24)31-16-17-6-9-26-10-7-17/h2-12,14-15,25H,13,16H2,1H3 SGNQXGVTWXGMFA-UHFFFAOYSA-N 100255 US20260001864, Compound 74 Potassium-transporting ATPase alpha chain 1 Homo sapiens 564 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100255&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 3231862 252663340 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130978 CNCc1cc(-c2ccc(OCCc3cc(F)cc(F)c3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H22F3N3O3S/c1-29-14-18-11-25(31(16-18)35(32,33)22-3-2-7-30-15-22)23-5-4-21(13-24(23)28)34-8-6-17-9-19(26)12-20(27)10-17/h2-5,7,9-13,15-16,29H,6,8,14H2,1H3 VHHSUNDOEAXLCN-UHFFFAOYSA-N 100256 US20260001864, Compound 99 Potassium-transporting ATPase alpha chain 1 Homo sapiens 72.6 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100256&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 255762 252663341 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130979 CNCc1cc(-c2ccc(OCC3CCOCC3)cc2F)n(S(=O)(=O)c2cccc(Cl)c2)c1 InChI=1S/C24H26ClFN2O4S/c1-27-14-18-11-24(28(15-18)33(29,30)21-4-2-3-19(25)12-21)22-6-5-20(13-23(22)26)32-16-17-7-9-31-10-8-17/h2-6,11-13,15,17,27H,7-10,14,16H2,1H3 AOAUACDDUGMFCW-UHFFFAOYSA-N 100257 US20260001864, Compound 25 Potassium-transporting ATPase alpha chain 1 Homo sapiens 58.5 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100257&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 181390 242053881 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130980 CNCc1cc(-c2ccc(OC[C@@H]3CO3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C20H20FN3O4S/c1-22-9-14-7-20(24(11-14)29(25,26)17-3-2-6-23-10-17)18-5-4-15(8-19(18)21)27-12-16-13-28-16/h2-8,10-11,16,22H,9,12-13H2,1H3 USUXVBSQBVOUOQ-UHFFFAOYSA-N 100258 US20260001864, Compound 50 Potassium-transporting ATPase alpha chain 1 Homo sapiens 114 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100258 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100258&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 24819709 252663342 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130981 CNCc1cc(-c2ccc(OCc3ccccc3OC)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C25H24FN3O4S/c1-27-14-18-12-24(29(16-18)34(30,31)21-7-5-11-28-15-21)22-10-9-20(13-23(22)26)33-17-19-6-3-4-8-25(19)32-2/h3-13,15-16,27H,14,17H2,1-2H3 PDHODLOXKTYYPT-UHFFFAOYSA-N 100260 US20260001864, Compound 75 Potassium-transporting ATPase alpha chain 1 Homo sapiens 36.6 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100260 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100260&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 45280985 252663344 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738 130982 CNCc1cc(-c2ccc(OCc3ccoc3)cc2F)n(S(=O)(=O)c2cccnc2)c1 InChI=1S/C22H20FN3O4S/c1-24-11-17-9-22(26(13-17)31(27,28)19-3-2-7-25-12-19)20-5-4-18(10-21(20)23)30-15-16-6-8-29-14-16/h2-10,12-14,24H,11,15H2,1H3 DSLYKOGBKJDHFY-UHFFFAOYSA-N 100261 US20260001864, Compound 100 Potassium-transporting ATPase alpha chain 1 Homo sapiens 101 US Patent 10.7270/Q2P55TBV US20260001864 HUANG, W; YANG, G; CHEN, T; ZHAO, S; GONG, Y; WANG, M 1/1/2026 5/13/2026 Nanjing Shuohui Pharmatechnology Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100261 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50000080&target=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100261&enzyme=Potassium-transporting+ATPase+alpha+chain+1&column=ki&startPg=0&Increment=50&submit=Search 431377 242053882 1 MGKAENYELYSVELGPGPGGDMAAKMSKKKKAGGGGGKRKEKLENMKKEMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGPNALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAIQASEGDLTTDDNLYLAIALIAVVVVTGCFGYYQEFKSTNIIASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPADIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEGTVQGLVVNTGDRTIIGRIASLASGVENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTFLRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYRDRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQLYLNEKDYPPGYAFDVEAMNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSELVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPRNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFPLLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAFQQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEIRKLGVRCCPGSWWDQELYY 6JXH,7EFL,6JXJ,6JXI Potassium-transporting ATPase alpha chain 1 ATP4A_HUMAN P20648 O00738