BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 131251 Cc1cc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(C)(=N)=O)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H27N5O2S/c1-11(2)16-10-21(17-5-12(3)20-23(17)18(16)24)8-13-6-15-7-14(13)9-22(15)26(4,19)25/h5,10-11,13-15,19H,6-9H2,1-4H3 SJJZZZVHGSTWMJ-UHFFFAOYSA-N 107255 6-isopropyl-2-methyl-4-(1S,4S,5S)-2-(S-methylsulfonimidoyl)-2-azabicyclo[2.2.1]heptan-5-yl)methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one::US20260001886, Compound 1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.398 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107255&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 69940614 175444702 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131252 Cc1cc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(C)(=N)=O)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H27N5O2S/c1-11(2)16-10-21(17-5-12(3)20-23(17)18(16)24)8-13-6-15-7-14(13)9-22(15)26(4,19)25/h5,10-11,13-15,19H,6-9H2,1-4H3 SJJZZZVHGSTWMJ-UHFFFAOYSA-N 107255 6-isopropyl-2-methyl-4-(1S,4S,5S)-2-(S-methylsulfonimidoyl)-2-azabicyclo[2.2.1]heptan-5-yl)methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one::US20260001886, Compound 1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.00 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107255&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 69940614 175444702 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131253 Cc1cc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(C)(=N)=O)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H27N5O2S/c1-11(2)16-10-21(17-5-12(3)20-23(17)18(16)24)8-13-6-15-7-14(13)9-22(15)26(4,19)25/h5,10-11,13-15,19H,6-9H2,1-4H3 SJJZZZVHGSTWMJ-UHFFFAOYSA-N 107255 6-isopropyl-2-methyl-4-(1S,4S,5S)-2-(S-methylsulfonimidoyl)-2-azabicyclo[2.2.1]heptan-5-yl)methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one::US20260001886, Compound 1 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107255&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 69940614 175444702 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131254 Cc1cc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(C)(=N)=O)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H27N5O2S/c1-11(2)16-10-21(17-5-12(3)20-23(17)18(16)24)8-13-6-15-7-14(13)9-22(15)26(4,19)25/h5,10-11,13-15,19H,6-9H2,1-4H3 SJJZZZVHGSTWMJ-UHFFFAOYSA-N 107255 6-isopropyl-2-methyl-4-(1S,4S,5S)-2-(S-methylsulfonimidoyl)-2-azabicyclo[2.2.1]heptan-5-yl)methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one::US20260001886, Compound 1 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107255 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107255&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 69940614 175444702 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131255 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3cccnc3)c(=O)n2n1 InChI=1S/C18H21N7O3S/c1-11-21-18-23(8-13-5-15-6-14(13)9-24(15)29(19,27)28)10-16(17(26)25(18)22-11)12-3-2-4-20-7-12/h2-4,7,10,13-15H,5-6,8-9H2,1H3,(H2,19,27,28) MUSXQDBEJOMILX-UHFFFAOYSA-N 107256 US20260001886, Compound 2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 251 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107256&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 69939872 175444703 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131256 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3cccnc3)c(=O)n2n1 InChI=1S/C18H21N7O3S/c1-11-21-18-23(8-13-5-15-6-14(13)9-24(15)29(19,27)28)10-16(17(26)25(18)22-11)12-3-2-4-20-7-12/h2-4,7,10,13-15H,5-6,8-9H2,1H3,(H2,19,27,28) MUSXQDBEJOMILX-UHFFFAOYSA-N 107256 US20260001886, Compound 2 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107256&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 69939872 175444703 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131257 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3cccnc3)c(=O)n2n1 InChI=1S/C18H21N7O3S/c1-11-21-18-23(8-13-5-15-6-14(13)9-24(15)29(19,27)28)10-16(17(26)25(18)22-11)12-3-2-4-20-7-12/h2-4,7,10,13-15H,5-6,8-9H2,1H3,(H2,19,27,28) MUSXQDBEJOMILX-UHFFFAOYSA-N 107256 US20260001886, Compound 2 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107256 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107256&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 69939872 175444703 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131258 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 107257 US20260001886, Compound 3A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.316 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107257&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 69940290 175444704 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131259 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 107257 US20260001886, Compound 3A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.158 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107257&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 69940290 175444704 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131260 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 107257 US20260001886, Compound 3A Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107257&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 69940290 175444704 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131261 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 107257 US20260001886, Compound 3A Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107257 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107257&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 69940290 175444704 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131262 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 107276 US20260001886, Compound 3B Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 316 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107276&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 69940148 175444723 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131263 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 107276 US20260001886, Compound 3B Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107276&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 69940148 175444723 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131264 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 107276 US20260001886, Compound 3B Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=107276 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=107276&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 69940148 175444723 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131265 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 114313 US20260001886, Compound 3 rac Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114313&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899714 252663819 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131266 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 114313 US20260001886, Compound 3 rac Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.631 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114313&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899714 252663819 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131267 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 114313 US20260001886, Compound 3 rac Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114313&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 91899714 252663819 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131268 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 114313 US20260001886, Compound 3 rac Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114313 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114313&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 91899714 252663819 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131269 Cc1nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c2c1Cl InChI=1S/C17H24ClN5O3S/c1-9(2)14-8-21(16-15(18)10(3)20-23(16)17(14)24)6-11-4-13-5-12(11)7-22(13)27(19,25)26/h8-9,11-13H,4-7H2,1-3H3,(H2,19,25,26) OLZFTNBOHWNYMX-UHFFFAOYSA-N 114314 US20260001886, Compound 4 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.631 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114314&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1473006 252663820 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131270 Cc1nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c2c1Cl InChI=1S/C17H24ClN5O3S/c1-9(2)14-8-21(16-15(18)10(3)20-23(16)17(14)24)6-11-4-13-5-12(11)7-22(13)27(19,25)26/h8-9,11-13H,4-7H2,1-3H3,(H2,19,25,26) OLZFTNBOHWNYMX-UHFFFAOYSA-N 114314 US20260001886, Compound 4 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114314&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1473006 252663820 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131271 Cc1nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c2c1Cl InChI=1S/C17H24ClN5O3S/c1-9(2)14-8-21(16-15(18)10(3)20-23(16)17(14)24)6-11-4-13-5-12(11)7-22(13)27(19,25)26/h8-9,11-13H,4-7H2,1-3H3,(H2,19,25,26) OLZFTNBOHWNYMX-UHFFFAOYSA-N 114314 US20260001886, Compound 4 Carbonic anhydrase 2 Homo sapiens 12589 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114314&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1473006 252663820 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131272 Cc1nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c2c1Cl InChI=1S/C17H24ClN5O3S/c1-9(2)14-8-21(16-15(18)10(3)20-23(16)17(14)24)6-11-4-13-5-12(11)7-22(13)27(19,25)26/h8-9,11-13H,4-7H2,1-3H3,(H2,19,25,26) OLZFTNBOHWNYMX-UHFFFAOYSA-N 114314 US20260001886, Compound 4 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114314 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114314&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1473006 252663820 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131273 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccncc3)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H24N6O3S/c1-14(2)19-13-28(23-26-21(17-4-5-17)27-29(23)22(19)30)12-15-3-6-20(33(24,31)32)18(11-15)16-7-9-25-10-8-16/h3,6-11,13-14,17H,4-5,12H2,1-2H3,(H2,24,31,32) GNKJRJJLSJEQAZ-UHFFFAOYSA-N 114315 US20260001886, Compound 5 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114315&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2151361 252663821 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131274 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccncc3)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H24N6O3S/c1-14(2)19-13-28(23-26-21(17-4-5-17)27-29(23)22(19)30)12-15-3-6-20(33(24,31)32)18(11-15)16-7-9-25-10-8-16/h3,6-11,13-14,17H,4-5,12H2,1-2H3,(H2,24,31,32) GNKJRJJLSJEQAZ-UHFFFAOYSA-N 114315 US20260001886, Compound 5 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.631 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114315&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2151361 252663821 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131275 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccncc3)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H24N6O3S/c1-14(2)19-13-28(23-26-21(17-4-5-17)27-29(23)22(19)30)12-15-3-6-20(33(24,31)32)18(11-15)16-7-9-25-10-8-16/h3,6-11,13-14,17H,4-5,12H2,1-2H3,(H2,24,31,32) GNKJRJJLSJEQAZ-UHFFFAOYSA-N 114315 US20260001886, Compound 5 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114315&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2151361 252663821 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131276 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccncc3)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H24N6O3S/c1-14(2)19-13-28(23-26-21(17-4-5-17)27-29(23)22(19)30)12-15-3-6-20(33(24,31)32)18(11-15)16-7-9-25-10-8-16/h3,6-11,13-14,17H,4-5,12H2,1-2H3,(H2,24,31,32) GNKJRJJLSJEQAZ-UHFFFAOYSA-N 114315 US20260001886, Compound 5 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114315 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114315&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2151361 252663821 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131277 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3cccc(F)c3)c(=O)n2n1 InChI=1S/C19H21FN6O3S/c1-11-22-19-24(8-13-6-16-7-14(13)9-25(16)30(21,28)29)10-17(18(27)26(19)23-11)12-3-2-4-15(20)5-12/h2-5,10,13-14,16H,6-9H2,1H3,(H2,21,28,29) JQOLRILUPNEWOS-UHFFFAOYSA-N 114330 US20260001886, Compound 6 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 100 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114330&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 865072 252663836 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131278 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3cccc(F)c3)c(=O)n2n1 InChI=1S/C19H21FN6O3S/c1-11-22-19-24(8-13-6-16-7-14(13)9-25(16)30(21,28)29)10-17(18(27)26(19)23-11)12-3-2-4-15(20)5-12/h2-5,10,13-14,16H,6-9H2,1H3,(H2,21,28,29) JQOLRILUPNEWOS-UHFFFAOYSA-N 114330 US20260001886, Compound 6 Carbonic anhydrase 2 Homo sapiens 251189 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114330&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 865072 252663836 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131279 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3cccc(F)c3)c(=O)n2n1 InChI=1S/C19H21FN6O3S/c1-11-22-19-24(8-13-6-16-7-14(13)9-25(16)30(21,28)29)10-17(18(27)26(19)23-11)12-3-2-4-15(20)5-12/h2-5,10,13-14,16H,6-9H2,1H3,(H2,21,28,29) JQOLRILUPNEWOS-UHFFFAOYSA-N 114330 US20260001886, Compound 6 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114330 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114330&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 865072 252663836 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131280 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 JUSQJQAEDDMPMS-UHFFFAOYSA-N 114331 US20260001886, Compound 7A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114331&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1435033 252663837 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131281 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 JUSQJQAEDDMPMS-UHFFFAOYSA-N 114331 US20260001886, Compound 7A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.794 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114331&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1435033 252663837 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131282 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 JUSQJQAEDDMPMS-UHFFFAOYSA-N 114331 US20260001886, Compound 7A Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114331&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1435033 252663837 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131283 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 JUSQJQAEDDMPMS-UHFFFAOYSA-N 114331 US20260001886, Compound 7A Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114331 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114331&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1435033 252663837 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131284 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 JUSQJQAEDDMPMS-UHFFFAOYSA-N 114332 US20260001886, Compound 7B Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3162 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114332&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3192185 252663838 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131285 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 JUSQJQAEDDMPMS-UHFFFAOYSA-N 114332 US20260001886, Compound 7B Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114332&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3192185 252663838 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131286 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 JUSQJQAEDDMPMS-UHFFFAOYSA-N 114332 US20260001886, Compound 7B Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114332 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114332&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 3192185 252663838 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131287 COCc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C20H25N5O4S/c1-12(2)16-10-24(20-22-18(14-5-6-14)23-25(20)19(16)26)9-13-4-7-17(30(21,27)28)15(8-13)11-29-3/h4,7-8,10,12,14H,5-6,9,11H2,1-3H3,(H2,21,27,28) JRIFSSWSPBLUIP-UHFFFAOYSA-N 114336 US20260001886, Compound 8 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114336&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 9659462 252663842 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131288 COCc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C20H25N5O4S/c1-12(2)16-10-24(20-22-18(14-5-6-14)23-25(20)19(16)26)9-13-4-7-17(30(21,27)28)15(8-13)11-29-3/h4,7-8,10,12,14H,5-6,9,11H2,1-3H3,(H2,21,27,28) JRIFSSWSPBLUIP-UHFFFAOYSA-N 114336 US20260001886, Compound 8 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114336&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 9659462 252663842 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131289 COCc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C20H25N5O4S/c1-12(2)16-10-24(20-22-18(14-5-6-14)23-25(20)19(16)26)9-13-4-7-17(30(21,27)28)15(8-13)11-29-3/h4,7-8,10,12,14H,5-6,9,11H2,1-3H3,(H2,21,27,28) JRIFSSWSPBLUIP-UHFFFAOYSA-N 114336 US20260001886, Compound 8 Carbonic anhydrase 2 Homo sapiens 63096 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114336&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 9659462 252663842 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131290 COCc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C20H25N5O4S/c1-12(2)16-10-24(20-22-18(14-5-6-14)23-25(20)19(16)26)9-13-4-7-17(30(21,27)28)15(8-13)11-29-3/h4,7-8,10,12,14H,5-6,9,11H2,1-3H3,(H2,21,27,28) JRIFSSWSPBLUIP-UHFFFAOYSA-N 114336 US20260001886, Compound 8 Carbonic anhydrase 1 Homo sapiens 100 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114336 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114336&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 9659462 252663842 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131291 Cc1cc2n(Cc3ccc([S@@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114337 US20260001886, Compound 9A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.501 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114337&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 6404569 252663843 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131292 Cc1cc2n(Cc3ccc([S@@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114337 US20260001886, Compound 9A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114337&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 6404569 252663843 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131293 Cc1cc2n(Cc3ccc([S@@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114337 US20260001886, Compound 9A Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114337&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 6404569 252663843 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131294 Cc1cc2n(Cc3ccc([S@@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114337 US20260001886, Compound 9A Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114337 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114337&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 6404569 252663843 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131295 Cc1cc2n(Cc3ccc([S@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114338 US20260001886, Compound 9B Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 158 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114338&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2238869 252663844 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131296 Cc1cc2n(Cc3ccc([S@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114338 US20260001886, Compound 9B Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114338&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2238869 252663844 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131297 Cc1cc2n(Cc3ccc([S@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114338 US20260001886, Compound 9B Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114338 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114338&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2238869 252663844 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131298 Cc1cc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114354 US20260001886, Compound 9 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114354&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 990451 252663860 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131299 Cc1cc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114354 US20260001886, Compound 9 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114354&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 990451 252663860 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131300 Cc1cc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114354 US20260001886, Compound 9 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114354&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 990451 252663860 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131301 Cc1cc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H22N4O2S/c1-12(2)16-11-21(17-9-13(3)20-22(17)18(16)23)10-14-5-7-15(8-6-14)25(4,19)24/h5-9,11-12,19H,10H2,1-4H3 UXSXJTPCIOLJAF-UHFFFAOYSA-N 114354 US20260001886, Compound 9 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114354 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114354&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 990451 252663860 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131302 Cc1nc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C18H22N6O3S/c1-10(2)14-9-23(8-13-6-7-15(11(3)20-13)28(19,26)27)18-21-16(12-4-5-12)22-24(18)17(14)25/h6-7,9-10,12H,4-5,8H2,1-3H3,(H2,19,26,27) KLJNAGRQENCZRT-UHFFFAOYSA-N 114355 US20260001886, Compound 10 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114355 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114355&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1234242 252663861 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131303 Cc1nc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C18H22N6O3S/c1-10(2)14-9-23(8-13-6-7-15(11(3)20-13)28(19,26)27)18-21-16(12-4-5-12)22-24(18)17(14)25/h6-7,9-10,12H,4-5,8H2,1-3H3,(H2,19,26,27) KLJNAGRQENCZRT-UHFFFAOYSA-N 114355 US20260001886, Compound 10 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 5.01 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114355 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114355&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1234242 252663861 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131304 Cc1nc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C18H22N6O3S/c1-10(2)14-9-23(8-13-6-7-15(11(3)20-13)28(19,26)27)18-21-16(12-4-5-12)22-24(18)17(14)25/h6-7,9-10,12H,4-5,8H2,1-3H3,(H2,19,26,27) KLJNAGRQENCZRT-UHFFFAOYSA-N 114355 US20260001886, Compound 10 Carbonic anhydrase 2 Homo sapiens 398 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114355 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114355&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1234242 252663861 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131305 Cc1nc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C18H22N6O3S/c1-10(2)14-9-23(8-13-6-7-15(11(3)20-13)28(19,26)27)18-21-16(12-4-5-12)22-24(18)17(14)25/h6-7,9-10,12H,4-5,8H2,1-3H3,(H2,19,26,27) KLJNAGRQENCZRT-UHFFFAOYSA-N 114355 US20260001886, Compound 10 Carbonic anhydrase 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114355 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114355&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1234242 252663861 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131306 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C18H21N5O3S/c1-11(2)15-10-22(9-12-3-7-14(8-4-12)27(19,25)26)18-20-16(13-5-6-13)21-23(18)17(15)24/h3-4,7-8,10-11,13H,5-6,9H2,1-2H3,(H2,19,25,26) POYABPTTWVHRSU-UHFFFAOYSA-N 114356 US20260001886, Compound 11 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114356 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114356&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 54710218 252663862 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131307 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C18H21N5O3S/c1-11(2)15-10-22(9-12-3-7-14(8-4-12)27(19,25)26)18-20-16(13-5-6-13)21-23(18)17(15)24/h3-4,7-8,10-11,13H,5-6,9H2,1-2H3,(H2,19,25,26) POYABPTTWVHRSU-UHFFFAOYSA-N 114356 US20260001886, Compound 11 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 7.94 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114356 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114356&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 54710218 252663862 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131308 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C18H21N5O3S/c1-11(2)15-10-22(9-12-3-7-14(8-4-12)27(19,25)26)18-20-16(13-5-6-13)21-23(18)17(15)24/h3-4,7-8,10-11,13H,5-6,9H2,1-2H3,(H2,19,25,26) POYABPTTWVHRSU-UHFFFAOYSA-N 114356 US20260001886, Compound 11 Carbonic anhydrase 2 Homo sapiens 79.4 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114356 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114356&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 54710218 252663862 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131309 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C18H21N5O3S/c1-11(2)15-10-22(9-12-3-7-14(8-4-12)27(19,25)26)18-20-16(13-5-6-13)21-23(18)17(15)24/h3-4,7-8,10-11,13H,5-6,9H2,1-2H3,(H2,19,25,26) POYABPTTWVHRSU-UHFFFAOYSA-N 114356 US20260001886, Compound 11 Carbonic anhydrase 1 Homo sapiens 158 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114356 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114356&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 54710218 252663862 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131310 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)15-10-24(9-13-6-7-14(8-16(13)20)28(3,21)27)19-22-17(12-4-5-12)23-25(19)18(15)26/h6-8,10-12,21H,4-5,9H2,1-3H3 OCEOZIJOINYLON-UHFFFAOYSA-N 114363 US20260001886, Compound 12 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 7.94 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114363&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2980985 252663869 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131311 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)15-10-24(9-13-6-7-14(8-16(13)20)28(3,21)27)19-22-17(12-4-5-12)23-25(19)18(15)26/h6-8,10-12,21H,4-5,9H2,1-3H3 OCEOZIJOINYLON-UHFFFAOYSA-N 114363 US20260001886, Compound 12 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114363&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2980985 252663869 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131312 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)15-10-24(9-13-6-7-14(8-16(13)20)28(3,21)27)19-22-17(12-4-5-12)23-25(19)18(15)26/h6-8,10-12,21H,4-5,9H2,1-3H3 OCEOZIJOINYLON-UHFFFAOYSA-N 114363 US20260001886, Compound 12 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114363 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114363&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2980985 252663869 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131313 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)nc2)c2nc(C3CC3)nn2c1=O InChI=1S/C17H20N6O3S/c1-10(2)13-9-22(8-11-3-6-14(19-7-11)27(18,25)26)17-20-15(12-4-5-12)21-23(17)16(13)24/h3,6-7,9-10,12H,4-5,8H2,1-2H3,(H2,18,25,26) QAZGDBFYURZOHW-UHFFFAOYSA-N 114364 US20260001886, Compound 13 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.00 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114364&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2237594 252663870 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131314 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)nc2)c2nc(C3CC3)nn2c1=O InChI=1S/C17H20N6O3S/c1-10(2)13-9-22(8-11-3-6-14(19-7-11)27(18,25)26)17-20-15(12-4-5-12)21-23(17)16(13)24/h3,6-7,9-10,12H,4-5,8H2,1-2H3,(H2,18,25,26) QAZGDBFYURZOHW-UHFFFAOYSA-N 114364 US20260001886, Compound 13 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114364&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2237594 252663870 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131315 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)nc2)c2nc(C3CC3)nn2c1=O InChI=1S/C17H20N6O3S/c1-10(2)13-9-22(8-11-3-6-14(19-7-11)27(18,25)26)17-20-15(12-4-5-12)21-23(17)16(13)24/h3,6-7,9-10,12H,4-5,8H2,1-2H3,(H2,18,25,26) QAZGDBFYURZOHW-UHFFFAOYSA-N 114364 US20260001886, Compound 13 Carbonic anhydrase 2 Homo sapiens 158 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114364&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2237594 252663870 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131316 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)nc2)c2nc(C3CC3)nn2c1=O InChI=1S/C17H20N6O3S/c1-10(2)13-9-22(8-11-3-6-14(19-7-11)27(18,25)26)17-20-15(12-4-5-12)21-23(17)16(13)24/h3,6-7,9-10,12H,4-5,8H2,1-2H3,(H2,18,25,26) QAZGDBFYURZOHW-UHFFFAOYSA-N 114364 US20260001886, Compound 13 Carbonic anhydrase 1 Homo sapiens 3162 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114364 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114364&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2237594 252663870 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131317 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3ccc(F)cc3)c(=O)n2n1 InChI=1S/C19H21FN6O3S/c1-11-22-19-24(8-13-6-16-7-14(13)9-25(16)30(21,28)29)10-17(18(27)26(19)23-11)12-2-4-15(20)5-3-12/h2-5,10,13-14,16H,6-9H2,1H3,(H2,21,28,29) RUEVNAKZCSAPCJ-UHFFFAOYSA-N 114365 US20260001886, Compound 14 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.98 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114365 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114365&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442565 252663871 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131318 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3ccc(F)cc3)c(=O)n2n1 InChI=1S/C19H21FN6O3S/c1-11-22-19-24(8-13-6-16-7-14(13)9-25(16)30(21,28)29)10-17(18(27)26(19)23-11)12-2-4-15(20)5-3-12/h2-5,10,13-14,16H,6-9H2,1H3,(H2,21,28,29) RUEVNAKZCSAPCJ-UHFFFAOYSA-N 114365 US20260001886, Compound 14 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114365 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114365&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1442565 252663871 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131319 Cc1nc2n(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)cc(-c3ccc(F)cc3)c(=O)n2n1 InChI=1S/C19H21FN6O3S/c1-11-22-19-24(8-13-6-16-7-14(13)9-25(16)30(21,28)29)10-17(18(27)26(19)23-11)12-2-4-15(20)5-3-12/h2-5,10,13-14,16H,6-9H2,1H3,(H2,21,28,29) RUEVNAKZCSAPCJ-UHFFFAOYSA-N 114365 US20260001886, Compound 14 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114365 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114365&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1442565 252663871 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131320 NS(=O)(=O)N1C[C@H]2C[C@@H]1C[C@@H]2Cn1cc(-c2ccccc2)c(=O)n2nc(C3CC3)nc12 InChI=1S/C21H24N6O3S/c22-31(29,30)26-11-16-9-17(26)8-15(16)10-25-12-18(13-4-2-1-3-5-13)20(28)27-21(25)23-19(24-27)14-6-7-14/h1-5,12,14-17H,6-11H2,(H2,22,29,30) LKRVLPZHDVWMBE-UHFFFAOYSA-N 114366 US20260001886, Compound 15 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 10.0 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114366&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442567 252663872 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131321 NS(=O)(=O)N1C[C@H]2C[C@@H]1C[C@@H]2Cn1cc(-c2ccccc2)c(=O)n2nc(C3CC3)nc12 InChI=1S/C21H24N6O3S/c22-31(29,30)26-11-16-9-17(26)8-15(16)10-25-12-18(13-4-2-1-3-5-13)20(28)27-21(25)23-19(24-27)14-6-7-14/h1-5,12,14-17H,6-11H2,(H2,22,29,30) LKRVLPZHDVWMBE-UHFFFAOYSA-N 114366 US20260001886, Compound 15 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114366&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442567 252663872 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131322 NS(=O)(=O)N1C[C@H]2C[C@@H]1C[C@@H]2Cn1cc(-c2ccccc2)c(=O)n2nc(C3CC3)nc12 InChI=1S/C21H24N6O3S/c22-31(29,30)26-11-16-9-17(26)8-15(16)10-25-12-18(13-4-2-1-3-5-13)20(28)27-21(25)23-19(24-27)14-6-7-14/h1-5,12,14-17H,6-11H2,(H2,22,29,30) LKRVLPZHDVWMBE-UHFFFAOYSA-N 114366 US20260001886, Compound 15 Carbonic anhydrase 2 Homo sapiens 63096 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114366&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1442567 252663872 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131323 NS(=O)(=O)N1C[C@H]2C[C@@H]1C[C@@H]2Cn1cc(-c2ccccc2)c(=O)n2nc(C3CC3)nc12 InChI=1S/C21H24N6O3S/c22-31(29,30)26-11-16-9-17(26)8-15(16)10-25-12-18(13-4-2-1-3-5-13)20(28)27-21(25)23-19(24-27)14-6-7-14/h1-5,12,14-17H,6-11H2,(H2,22,29,30) LKRVLPZHDVWMBE-UHFFFAOYSA-N 114366 US20260001886, Compound 15 Carbonic anhydrase 1 Homo sapiens 125893 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114366 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114366&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1442567 252663872 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131324 Cc1cc2n(Cc3ccc(S(N)(=O)=O)nc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C16H19N5O3S/c1-10(2)13-9-20(15-6-11(3)19-21(15)16(13)22)8-12-4-5-14(18-7-12)25(17,23)24/h4-7,9-10H,8H2,1-3H3,(H2,17,23,24) ANGQKWPBEWJRFV-UHFFFAOYSA-N 114367 US20260001886, Compound 16 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.51 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114367&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442473 252663873 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131325 Cc1cc2n(Cc3ccc(S(N)(=O)=O)nc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C16H19N5O3S/c1-10(2)13-9-20(15-6-11(3)19-21(15)16(13)22)8-12-4-5-14(18-7-12)25(17,23)24/h4-7,9-10H,8H2,1-3H3,(H2,17,23,24) ANGQKWPBEWJRFV-UHFFFAOYSA-N 114367 US20260001886, Compound 16 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114367&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442473 252663873 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131326 Cc1cc2n(Cc3ccc(S(N)(=O)=O)nc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C16H19N5O3S/c1-10(2)13-9-20(15-6-11(3)19-21(15)16(13)22)8-12-4-5-14(18-7-12)25(17,23)24/h4-7,9-10H,8H2,1-3H3,(H2,17,23,24) ANGQKWPBEWJRFV-UHFFFAOYSA-N 114367 US20260001886, Compound 16 Carbonic anhydrase 2 Homo sapiens 1000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114367&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1442473 252663873 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131327 Cc1cc2n(Cc3ccc(S(N)(=O)=O)nc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C16H19N5O3S/c1-10(2)13-9-20(15-6-11(3)19-21(15)16(13)22)8-12-4-5-14(18-7-12)25(17,23)24/h4-7,9-10H,8H2,1-3H3,(H2,17,23,24) ANGQKWPBEWJRFV-UHFFFAOYSA-N 114367 US20260001886, Compound 16 Carbonic anhydrase 1 Homo sapiens 3981 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114367 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114367&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1442473 252663873 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131328 Cc1cc2n(Cc3ccc(S(N)(=O)=O)cc3F)cc(C(C)C)c(=O)n2n1 InChI=1S/C17H19FN4O3S/c1-10(2)14-9-21(16-6-11(3)20-22(16)17(14)23)8-12-4-5-13(7-15(12)18)26(19,24)25/h4-7,9-10H,8H2,1-3H3,(H2,19,24,25) RHSVROLTHHPJIF-UHFFFAOYSA-N 114368 US20260001886, Compound 17 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114368 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114368&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1632391 252663874 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131329 Cc1cc2n(Cc3ccc(S(N)(=O)=O)cc3F)cc(C(C)C)c(=O)n2n1 InChI=1S/C17H19FN4O3S/c1-10(2)14-9-21(16-6-11(3)20-22(16)17(14)23)8-12-4-5-13(7-15(12)18)26(19,24)25/h4-7,9-10H,8H2,1-3H3,(H2,19,24,25) RHSVROLTHHPJIF-UHFFFAOYSA-N 114368 US20260001886, Compound 17 Carbonic anhydrase 2 Homo sapiens 25.1 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114368 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114368&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1632391 252663874 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131330 Cc1cc2n(Cc3ccc(S(N)(=O)=O)cc3F)cc(C(C)C)c(=O)n2n1 InChI=1S/C17H19FN4O3S/c1-10(2)14-9-21(16-6-11(3)20-22(16)17(14)23)8-12-4-5-13(7-15(12)18)26(19,24)25/h4-7,9-10H,8H2,1-3H3,(H2,19,24,25) RHSVROLTHHPJIF-UHFFFAOYSA-N 114368 US20260001886, Compound 17 Carbonic anhydrase 1 Homo sapiens 316 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114368 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114368&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1632391 252663874 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131331 Cc1cc2n(Cc3ccc(S(N)(=O)=O)c(OC(F)F)c3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H20F2N4O4S/c1-10(2)13-9-23(16-6-11(3)22-24(16)17(13)25)8-12-4-5-15(29(21,26)27)14(7-12)28-18(19)20/h4-7,9-10,18H,8H2,1-3H3,(H2,21,26,27) XNKRAQMNXCFKLK-UHFFFAOYSA-N 114369 US20260001886, Compound 18 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 5.01 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114369&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442564 252663875 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131332 Cc1cc2n(Cc3ccc(S(N)(=O)=O)c(OC(F)F)c3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H20F2N4O4S/c1-10(2)13-9-23(16-6-11(3)22-24(16)17(13)25)8-12-4-5-15(29(21,26)27)14(7-12)28-18(19)20/h4-7,9-10,18H,8H2,1-3H3,(H2,21,26,27) XNKRAQMNXCFKLK-UHFFFAOYSA-N 114369 US20260001886, Compound 18 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.00 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114369&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442564 252663875 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131333 Cc1cc2n(Cc3ccc(S(N)(=O)=O)c(OC(F)F)c3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H20F2N4O4S/c1-10(2)13-9-23(16-6-11(3)22-24(16)17(13)25)8-12-4-5-15(29(21,26)27)14(7-12)28-18(19)20/h4-7,9-10,18H,8H2,1-3H3,(H2,21,26,27) XNKRAQMNXCFKLK-UHFFFAOYSA-N 114369 US20260001886, Compound 18 Carbonic anhydrase 2 Homo sapiens 39811 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114369&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1442564 252663875 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131334 Cc1cc2n(Cc3ccc(S(N)(=O)=O)c(OC(F)F)c3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H20F2N4O4S/c1-10(2)13-9-23(16-6-11(3)22-24(16)17(13)25)8-12-4-5-15(29(21,26)27)14(7-12)28-18(19)20/h4-7,9-10,18H,8H2,1-3H3,(H2,21,26,27) XNKRAQMNXCFKLK-UHFFFAOYSA-N 114369 US20260001886, Compound 18 Carbonic anhydrase 1 Homo sapiens 5012 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114369 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114369&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1442564 252663875 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131335 Cc1cc2n(Cc3ccc(S(N)(=O)=O)cc3)cc(-c3ccccc3)c(=O)n2n1 InChI=1S/C20H18N4O3S/c1-14-11-19-23(12-15-7-9-17(10-8-15)28(21,26)27)13-18(20(25)24(19)22-14)16-5-3-2-4-6-16/h2-11,13H,12H2,1H3,(H2,21,26,27) VCBFKJOKZGNMGZ-UHFFFAOYSA-N 114370 US20260001886, Compound 19 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 50.1 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114370 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114370&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 746456 252663876 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131336 Cc1cc2n(Cc3ccc(S(N)(=O)=O)cc3)cc(-c3ccccc3)c(=O)n2n1 InChI=1S/C20H18N4O3S/c1-14-11-19-23(12-15-7-9-17(10-8-15)28(21,26)27)13-18(20(25)24(19)22-14)16-5-3-2-4-6-16/h2-11,13H,12H2,1H3,(H2,21,26,27) VCBFKJOKZGNMGZ-UHFFFAOYSA-N 114370 US20260001886, Compound 19 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114370 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114370&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 746456 252663876 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131337 Cc1cc2n(Cc3ccc(S(N)(=O)=O)cc3)cc(-c3ccccc3)c(=O)n2n1 InChI=1S/C20H18N4O3S/c1-14-11-19-23(12-15-7-9-17(10-8-15)28(21,26)27)13-18(20(25)24(19)22-14)16-5-3-2-4-6-16/h2-11,13H,12H2,1H3,(H2,21,26,27) VCBFKJOKZGNMGZ-UHFFFAOYSA-N 114370 US20260001886, Compound 19 Carbonic anhydrase 2 Homo sapiens 1000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114370 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114370&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 746456 252663876 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131338 Cc1cc2n(Cc3ccc(S(N)(=O)=O)cc3)cc(-c3ccccc3)c(=O)n2n1 InChI=1S/C20H18N4O3S/c1-14-11-19-23(12-15-7-9-17(10-8-15)28(21,26)27)13-18(20(25)24(19)22-14)16-5-3-2-4-6-16/h2-11,13H,12H2,1H3,(H2,21,26,27) VCBFKJOKZGNMGZ-UHFFFAOYSA-N 114370 US20260001886, Compound 19 Carbonic anhydrase 1 Homo sapiens 1995 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114370 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114370&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 746456 252663876 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131339 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(C(F)(F)F)c2)c2cc(C3CC3)nn2c1=O InChI=1S/C21H23F3N4O2S/c1-12(2)15-11-27(19-9-17(14-5-6-14)26-28(19)20(15)29)10-13-4-7-18(31(3,25)30)16(8-13)21(22,23)24/h4,7-9,11-12,14,25H,5-6,10H2,1-3H3 ZXUPPBBXNKCVAE-UHFFFAOYSA-N 114371 US20260001886, Compound 20 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114371 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114371&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2939635 252663877 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131340 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(C(F)(F)F)c2)c2cc(C3CC3)nn2c1=O InChI=1S/C21H23F3N4O2S/c1-12(2)15-11-27(19-9-17(14-5-6-14)26-28(19)20(15)29)10-13-4-7-18(31(3,25)30)16(8-13)21(22,23)24/h4,7-9,11-12,14,25H,5-6,10H2,1-3H3 ZXUPPBBXNKCVAE-UHFFFAOYSA-N 114371 US20260001886, Compound 20 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114371 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114371&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2939635 252663877 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131341 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(C(F)(F)F)c2)c2cc(C3CC3)nn2c1=O InChI=1S/C21H23F3N4O2S/c1-12(2)15-11-27(19-9-17(14-5-6-14)26-28(19)20(15)29)10-13-4-7-18(31(3,25)30)16(8-13)21(22,23)24/h4,7-9,11-12,14,25H,5-6,10H2,1-3H3 ZXUPPBBXNKCVAE-UHFFFAOYSA-N 114371 US20260001886, Compound 20 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114371 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114371&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2939635 252663877 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131342 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccc(F)cn3)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H23FN6O3S/c1-13(2)18-12-29(23-27-21(15-4-5-15)28-30(23)22(18)31)11-14-3-8-20(34(25,32)33)17(9-14)19-7-6-16(24)10-26-19/h3,6-10,12-13,15H,4-5,11H2,1-2H3,(H2,25,32,33) GHBWVFUVXYUXBT-UHFFFAOYSA-N 114372 US20260001886, Compound 21 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114372 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114372&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899716 252663878 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131343 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccc(F)cn3)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H23FN6O3S/c1-13(2)18-12-29(23-27-21(15-4-5-15)28-30(23)22(18)31)11-14-3-8-20(34(25,32)33)17(9-14)19-7-6-16(24)10-26-19/h3,6-10,12-13,15H,4-5,11H2,1-2H3,(H2,25,32,33) GHBWVFUVXYUXBT-UHFFFAOYSA-N 114372 US20260001886, Compound 21 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114372 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114372&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899716 252663878 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131344 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccc(F)cn3)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H23FN6O3S/c1-13(2)18-12-29(23-27-21(15-4-5-15)28-30(23)22(18)31)11-14-3-8-20(34(25,32)33)17(9-14)19-7-6-16(24)10-26-19/h3,6-10,12-13,15H,4-5,11H2,1-2H3,(H2,25,32,33) GHBWVFUVXYUXBT-UHFFFAOYSA-N 114372 US20260001886, Compound 21 Carbonic anhydrase 2 Homo sapiens 7943 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114372 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114372&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 91899716 252663878 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131345 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccc(F)cn3)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H23FN6O3S/c1-13(2)18-12-29(23-27-21(15-4-5-15)28-30(23)22(18)31)11-14-3-8-20(34(25,32)33)17(9-14)19-7-6-16(24)10-26-19/h3,6-10,12-13,15H,4-5,11H2,1-2H3,(H2,25,32,33) GHBWVFUVXYUXBT-UHFFFAOYSA-N 114372 US20260001886, Compound 21 Carbonic anhydrase 1 Homo sapiens 31623 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114372 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114372&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 91899716 252663878 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131346 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C19H23N5O3S/c1-11(2)15-10-23(9-13-4-7-16(12(3)8-13)28(20,26)27)19-21-17(14-5-6-14)22-24(19)18(15)25/h4,7-8,10-11,14H,5-6,9H2,1-3H3,(H2,20,26,27) OUTGGKRJDDUJIJ-UHFFFAOYSA-N 114373 US20260001886, Compound 22 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.51 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114373&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 856427 252663879 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131347 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C19H23N5O3S/c1-11(2)15-10-23(9-13-4-7-16(12(3)8-13)28(20,26)27)19-21-17(14-5-6-14)22-24(19)18(15)25/h4,7-8,10-11,14H,5-6,9H2,1-3H3,(H2,20,26,27) OUTGGKRJDDUJIJ-UHFFFAOYSA-N 114373 US20260001886, Compound 22 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.51 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114373&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 856427 252663879 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131348 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C19H23N5O3S/c1-11(2)15-10-23(9-13-4-7-16(12(3)8-13)28(20,26)27)19-21-17(14-5-6-14)22-24(19)18(15)25/h4,7-8,10-11,14H,5-6,9H2,1-3H3,(H2,20,26,27) OUTGGKRJDDUJIJ-UHFFFAOYSA-N 114373 US20260001886, Compound 22 Carbonic anhydrase 2 Homo sapiens 631 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114373&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 856427 252663879 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131349 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C19H23N5O3S/c1-11(2)15-10-23(9-13-4-7-16(12(3)8-13)28(20,26)27)19-21-17(14-5-6-14)22-24(19)18(15)25/h4,7-8,10-11,14H,5-6,9H2,1-3H3,(H2,20,26,27) OUTGGKRJDDUJIJ-UHFFFAOYSA-N 114373 US20260001886, Compound 22 Carbonic anhydrase 1 Homo sapiens 39.8 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114373 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114373&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 856427 252663879 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131350 CC(C)c1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C21H27N5O3S/c1-12(2)16-9-14(5-8-18(16)30(22,28)29)10-25-11-17(13(3)4)20(27)26-21(25)23-19(24-26)15-6-7-15/h5,8-9,11-13,15H,6-7,10H2,1-4H3,(H2,22,28,29) RPCCMTKMZOZHTF-UHFFFAOYSA-N 114374 US20260001886, Compound 23 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114374&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1435045 252663880 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131351 CC(C)c1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C21H27N5O3S/c1-12(2)16-9-14(5-8-18(16)30(22,28)29)10-25-11-17(13(3)4)20(27)26-21(25)23-19(24-26)15-6-7-15/h5,8-9,11-13,15H,6-7,10H2,1-4H3,(H2,22,28,29) RPCCMTKMZOZHTF-UHFFFAOYSA-N 114374 US20260001886, Compound 23 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.98 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114374&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1435045 252663880 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131352 CC(C)c1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C21H27N5O3S/c1-12(2)16-9-14(5-8-18(16)30(22,28)29)10-25-11-17(13(3)4)20(27)26-21(25)23-19(24-26)15-6-7-15/h5,8-9,11-13,15H,6-7,10H2,1-4H3,(H2,22,28,29) RPCCMTKMZOZHTF-UHFFFAOYSA-N 114374 US20260001886, Compound 23 Carbonic anhydrase 2 Homo sapiens 398 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114374&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1435045 252663880 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131353 CC(C)c1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(N)(=O)=O InChI=1S/C21H27N5O3S/c1-12(2)16-9-14(5-8-18(16)30(22,28)29)10-25-11-17(13(3)4)20(27)26-21(25)23-19(24-26)15-6-7-15/h5,8-9,11-13,15H,6-7,10H2,1-4H3,(H2,22,28,29) RPCCMTKMZOZHTF-UHFFFAOYSA-N 114374 US20260001886, Compound 23 Carbonic anhydrase 1 Homo sapiens 794 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114374 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114374&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1435045 252663880 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131354 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2O)c2nc(C3CC3)nn2c1=O InChI=1S/C18H21N5O4S/c1-10(2)14-9-22(8-12-5-6-13(7-15(12)24)28(19,26)27)18-20-16(11-3-4-11)21-23(18)17(14)25/h5-7,9-11,24H,3-4,8H2,1-2H3,(H2,19,26,27) TVGGVTHWZIYBQE-UHFFFAOYSA-N 114375 US20260001886, Compound 24 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.98 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114375&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3207945 252663881 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131355 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2O)c2nc(C3CC3)nn2c1=O InChI=1S/C18H21N5O4S/c1-10(2)14-9-22(8-12-5-6-13(7-15(12)24)28(19,26)27)18-20-16(11-3-4-11)21-23(18)17(14)25/h5-7,9-11,24H,3-4,8H2,1-2H3,(H2,19,26,27) TVGGVTHWZIYBQE-UHFFFAOYSA-N 114375 US20260001886, Compound 24 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114375&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3207945 252663881 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131356 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2O)c2nc(C3CC3)nn2c1=O InChI=1S/C18H21N5O4S/c1-10(2)14-9-22(8-12-5-6-13(7-15(12)24)28(19,26)27)18-20-16(11-3-4-11)21-23(18)17(14)25/h5-7,9-11,24H,3-4,8H2,1-2H3,(H2,19,26,27) TVGGVTHWZIYBQE-UHFFFAOYSA-N 114375 US20260001886, Compound 24 Carbonic anhydrase 2 Homo sapiens 251 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114375&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3207945 252663881 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131357 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2O)c2nc(C3CC3)nn2c1=O InChI=1S/C18H21N5O4S/c1-10(2)14-9-22(8-12-5-6-13(7-15(12)24)28(19,26)27)18-20-16(11-3-4-11)21-23(18)17(14)25/h5-7,9-11,24H,3-4,8H2,1-2H3,(H2,19,26,27) TVGGVTHWZIYBQE-UHFFFAOYSA-N 114375 US20260001886, Compound 24 Carbonic anhydrase 1 Homo sapiens 126 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114375 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114375&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 3207945 252663881 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131358 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2nc(OC3CC3)nn2c1=O InChI=1S/C19H23N5O3S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)28(3,20)26)19-21-18(27-14-6-7-14)22-24(19)17(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 LPYPRVHNCPUGKB-UHFFFAOYSA-N 114376 US20260001886, Compound 25 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114376&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 737004 252663882 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131359 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2nc(OC3CC3)nn2c1=O InChI=1S/C19H23N5O3S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)28(3,20)26)19-21-18(27-14-6-7-14)22-24(19)17(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 LPYPRVHNCPUGKB-UHFFFAOYSA-N 114376 US20260001886, Compound 25 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114376&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 737004 252663882 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131360 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2nc(OC3CC3)nn2c1=O InChI=1S/C19H23N5O3S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)28(3,20)26)19-21-18(27-14-6-7-14)22-24(19)17(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3 LPYPRVHNCPUGKB-UHFFFAOYSA-N 114376 US20260001886, Compound 25 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114376 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114376&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 737004 252663882 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131361 CC(C)c1cn(Cc2c(F)cc(S(C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H21F2N5O2S/c1-10(2)13-8-25(19-23-17(11-4-5-11)24-26(19)18(13)27)9-14-15(20)6-12(7-16(14)21)29(3,22)28/h6-8,10-11,22H,4-5,9H2,1-3H3 VZCNJGJOHCOBRK-UHFFFAOYSA-N 114377 US20260001886, Compound 26 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 12.6 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114377 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114377&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 540833 252663883 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131362 CC(C)c1cn(Cc2c(F)cc(S(C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H21F2N5O2S/c1-10(2)13-8-25(19-23-17(11-4-5-11)24-26(19)18(13)27)9-14-15(20)6-12(7-16(14)21)29(3,22)28/h6-8,10-11,22H,4-5,9H2,1-3H3 VZCNJGJOHCOBRK-UHFFFAOYSA-N 114377 US20260001886, Compound 26 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114377 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114377&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 540833 252663883 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131363 CC(C)c1cn(Cc2c(F)cc(S(C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H21F2N5O2S/c1-10(2)13-8-25(19-23-17(11-4-5-11)24-26(19)18(13)27)9-14-15(20)6-12(7-16(14)21)29(3,22)28/h6-8,10-11,22H,4-5,9H2,1-3H3 VZCNJGJOHCOBRK-UHFFFAOYSA-N 114377 US20260001886, Compound 26 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114377 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114377&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 540833 252663883 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131364 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccccc3)n2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H24N6O3S/c1-14(2)18-13-28(23-26-21(16-8-9-16)27-29(23)22(18)30)12-17-10-11-19(33(24,31)32)20(25-17)15-6-4-3-5-7-15/h3-7,10-11,13-14,16H,8-9,12H2,1-2H3,(H2,24,31,32) OSJGOWOHRTYXGI-UHFFFAOYSA-N 114378 US20260001886, Compound 27 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114378&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442861 252663884 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131365 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccccc3)n2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H24N6O3S/c1-14(2)18-13-28(23-26-21(16-8-9-16)27-29(23)22(18)30)12-17-10-11-19(33(24,31)32)20(25-17)15-6-4-3-5-7-15/h3-7,10-11,13-14,16H,8-9,12H2,1-2H3,(H2,24,31,32) OSJGOWOHRTYXGI-UHFFFAOYSA-N 114378 US20260001886, Compound 27 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114378&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1442861 252663884 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131366 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)c(-c3ccccc3)n2)c2nc(C3CC3)nn2c1=O InChI=1S/C23H24N6O3S/c1-14(2)18-13-28(23-26-21(16-8-9-16)27-29(23)22(18)30)12-17-10-11-19(33(24,31)32)20(25-17)15-6-4-3-5-7-15/h3-7,10-11,13-14,16H,8-9,12H2,1-2H3,(H2,24,31,32) OSJGOWOHRTYXGI-UHFFFAOYSA-N 114378 US20260001886, Compound 27 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114378 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114378&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1442861 252663884 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131367 CCCc1nc2n(Cc3ccc(S(N)(=O)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O3S/c1-4-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)27(19,25)26/h6-9,11-12H,4-5,10H2,1-3H3,(H2,19,25,26) SBVQNEUNSIIDRA-UHFFFAOYSA-N 114379 US20260001886, Compound 28 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114379&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 865071 252663885 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131368 CCCc1nc2n(Cc3ccc(S(N)(=O)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O3S/c1-4-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)27(19,25)26/h6-9,11-12H,4-5,10H2,1-3H3,(H2,19,25,26) SBVQNEUNSIIDRA-UHFFFAOYSA-N 114379 US20260001886, Compound 28 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.00 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114379&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 865071 252663885 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131369 CCCc1nc2n(Cc3ccc(S(N)(=O)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O3S/c1-4-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)27(19,25)26/h6-9,11-12H,4-5,10H2,1-3H3,(H2,19,25,26) SBVQNEUNSIIDRA-UHFFFAOYSA-N 114379 US20260001886, Compound 28 Carbonic anhydrase 2 Homo sapiens 200 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114379&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 865071 252663885 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131370 CCCc1nc2n(Cc3ccc(S(N)(=O)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O3S/c1-4-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)27(19,25)26/h6-9,11-12H,4-5,10H2,1-3H3,(H2,19,25,26) SBVQNEUNSIIDRA-UHFFFAOYSA-N 114379 US20260001886, Compound 28 Carbonic anhydrase 1 Homo sapiens 251 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114379 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114379&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 865071 252663885 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131371 CNc1nc([SH](=O)=O)ccc1Cn1cc(C(C)C)c(=O)n2nc(C3CC3)nc12 InChI=1S/C18H22N6O3S/c1-10(2)13-9-23(8-12-6-7-14(28(26)27)20-15(12)19-3)18-21-16(11-4-5-11)22-24(18)17(13)25/h6-7,9-11,28H,4-5,8H2,1-3H3,(H,19,20) WBWSBSFWNHTYHT-UHFFFAOYSA-N 114380 US20260001886, Compound 29 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114380&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3221482 252663886 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131372 CNc1nc([SH](=O)=O)ccc1Cn1cc(C(C)C)c(=O)n2nc(C3CC3)nc12 InChI=1S/C18H22N6O3S/c1-10(2)13-9-23(8-12-6-7-14(28(26)27)20-15(12)19-3)18-21-16(11-4-5-11)22-24(18)17(13)25/h6-7,9-11,28H,4-5,8H2,1-3H3,(H,19,20) WBWSBSFWNHTYHT-UHFFFAOYSA-N 114380 US20260001886, Compound 29 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 25.1 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114380&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3221482 252663886 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131373 CNc1nc([SH](=O)=O)ccc1Cn1cc(C(C)C)c(=O)n2nc(C3CC3)nc12 InChI=1S/C18H22N6O3S/c1-10(2)13-9-23(8-12-6-7-14(28(26)27)20-15(12)19-3)18-21-16(11-4-5-11)22-24(18)17(13)25/h6-7,9-11,28H,4-5,8H2,1-3H3,(H,19,20) WBWSBSFWNHTYHT-UHFFFAOYSA-N 114380 US20260001886, Compound 29 Carbonic anhydrase 2 Homo sapiens 31623 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114380&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3221482 252663886 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131374 CNc1nc([SH](=O)=O)ccc1Cn1cc(C(C)C)c(=O)n2nc(C3CC3)nc12 InChI=1S/C18H22N6O3S/c1-10(2)13-9-23(8-12-6-7-14(28(26)27)20-15(12)19-3)18-21-16(11-4-5-11)22-24(18)17(13)25/h6-7,9-11,28H,4-5,8H2,1-3H3,(H,19,20) WBWSBSFWNHTYHT-UHFFFAOYSA-N 114380 US20260001886, Compound 29 Carbonic anhydrase 1 Homo sapiens 7943 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114380 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114380&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 3221482 252663886 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131375 CC(C)c1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C19H25N5O2S/c1-12(2)16-11-23(10-14-6-8-15(9-7-14)27(5,20)26)19-21-17(13(3)4)22-24(19)18(16)25/h6-9,11-13,20H,10H2,1-5H3 CHOOCTOKVLWIDZ-UHFFFAOYSA-N 114381 US20260001886, Compound 30 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.98 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114381&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442627 252663887 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131376 CC(C)c1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C19H25N5O2S/c1-12(2)16-11-23(10-14-6-8-15(9-7-14)27(5,20)26)19-21-17(13(3)4)22-24(19)18(16)25/h6-9,11-13,20H,10H2,1-5H3 CHOOCTOKVLWIDZ-UHFFFAOYSA-N 114381 US20260001886, Compound 30 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114381&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1442627 252663887 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131377 CC(C)c1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C19H25N5O2S/c1-12(2)16-11-23(10-14-6-8-15(9-7-14)27(5,20)26)19-21-17(13(3)4)22-24(19)18(16)25/h6-9,11-13,20H,10H2,1-5H3 CHOOCTOKVLWIDZ-UHFFFAOYSA-N 114381 US20260001886, Compound 30 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114381 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114381&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1442627 252663887 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131378 CCc1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114382 US20260001886, Compound 31 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114382&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1176113 252663888 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131379 CCc1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114382 US20260001886, Compound 31 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114382&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1176113 252663888 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131380 CCc1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114382 US20260001886, Compound 31 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114382 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114382&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1176113 252663888 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131381 CCc1nc2n(Cc3ccc([S@@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114383 US20260001886, Compound 31A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.98 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114383&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3635365 252663889 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131382 CCc1nc2n(Cc3ccc([S@@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114383 US20260001886, Compound 31A Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114383&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3635365 252663889 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131383 CCc1nc2n(Cc3ccc([S@@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114383 US20260001886, Compound 31A Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114383 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114383&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 3635365 252663889 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131384 CCc1nc2n(Cc3ccc([S@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114384 US20260001886, Compound 31B Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114384&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3167727 252663890 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131385 CCc1nc2n(Cc3ccc([S@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114384 US20260001886, Compound 31B Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114384&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3167727 252663890 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131386 CCc1nc2n(Cc3ccc([S@](C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O2S/c1-5-16-20-18-22(11-15(12(2)3)17(24)23(18)21-16)10-13-6-8-14(9-7-13)26(4,19)25/h6-9,11-12,19H,5,10H2,1-4H3 FRQWOKKDQPYFGE-UHFFFAOYSA-N 114384 US20260001886, Compound 31B Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114384 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114384&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 3167727 252663890 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131387 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114385 US20260001886, Compound 32A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114385&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442821 252663891 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131388 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114385 US20260001886, Compound 32A Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114385&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1442821 252663891 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131389 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114385 US20260001886, Compound 32A Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114385 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114385&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1442821 252663891 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131390 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114386 US20260001886, Compound 32B Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114386 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114386&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2766814 252663892 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131391 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114386 US20260001886, Compound 32B Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114386 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114386&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2766814 252663892 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131392 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114386 US20260001886, Compound 32B Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114386 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114386&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2766814 252663892 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131393 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114387 US20260001886, Compound 32 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 7.94 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114387 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114387&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 5048043 252663893 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131394 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114387 US20260001886, Compound 32 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114387 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114387&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 5048043 252663893 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131395 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2nc(CC(F)(F)F)nn2c1=O InChI=1S/C18H20F3N5O2S/c1-11(2)14-10-25(9-12-4-6-13(7-5-12)29(3,22)28)17-23-15(8-18(19,20)21)24-26(17)16(14)27/h4-7,10-11,22H,8-9H2,1-3H3 DLMDZZJLINGJJX-UHFFFAOYSA-N 114387 US20260001886, Compound 32 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114387 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114387&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 5048043 252663893 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131396 COCc1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O3S/c1-12(2)15-10-22(9-13-5-7-14(8-6-13)27(4,19)25)18-20-16(11-26-3)21-23(18)17(15)24/h5-8,10,12,19H,9,11H2,1-4H3 ONUGBRCTYUOKNH-UHFFFAOYSA-N 114388 US20260001886, Compound 33 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 7.94 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114388&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 5135882 252663894 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131397 COCc1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O3S/c1-12(2)15-10-22(9-13-5-7-14(8-6-13)27(4,19)25)18-20-16(11-26-3)21-23(18)17(15)24/h5-8,10,12,19H,9,11H2,1-4H3 ONUGBRCTYUOKNH-UHFFFAOYSA-N 114388 US20260001886, Compound 33 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114388&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 5135882 252663894 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131398 COCc1nc2n(Cc3ccc(S(C)(=N)=O)cc3)cc(C(C)C)c(=O)n2n1 InChI=1S/C18H23N5O3S/c1-12(2)15-10-22(9-13-5-7-14(8-6-13)27(4,19)25)18-20-16(11-26-3)21-23(18)17(15)24/h5-8,10,12,19H,9,11H2,1-4H3 ONUGBRCTYUOKNH-UHFFFAOYSA-N 114388 US20260001886, Compound 33 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114388 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114388&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 5135882 252663894 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131399 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2nc(Cl)nn2c1=O InChI=1S/C15H21ClN6O3S/c1-8(2)12-7-20(15-18-14(16)19-22(15)13(12)23)5-9-3-11-4-10(9)6-21(11)26(17,24)25/h7-11H,3-6H2,1-2H3,(H2,17,24,25) DNLDAUVVBYQVFR-UHFFFAOYSA-N 114389 US20260001886, Compound 34 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 15.8 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114389&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2334933 252663895 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131400 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2nc(Cl)nn2c1=O InChI=1S/C15H21ClN6O3S/c1-8(2)12-7-20(15-18-14(16)19-22(15)13(12)23)5-9-3-11-4-10(9)6-21(11)26(17,24)25/h7-11H,3-6H2,1-2H3,(H2,17,24,25) DNLDAUVVBYQVFR-UHFFFAOYSA-N 114389 US20260001886, Compound 34 Carbonic anhydrase 2 Homo sapiens 79433 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114389&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2334933 252663895 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131401 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2nc(Cl)nn2c1=O InChI=1S/C15H21ClN6O3S/c1-8(2)12-7-20(15-18-14(16)19-22(15)13(12)23)5-9-3-11-4-10(9)6-21(11)26(17,24)25/h7-11H,3-6H2,1-2H3,(H2,17,24,25) DNLDAUVVBYQVFR-UHFFFAOYSA-N 114389 US20260001886, Compound 34 Carbonic anhydrase 1 Homo sapiens 100000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114389 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114389&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2334933 252663895 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131402 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc([C@H]3CC3(C)C)nn2c1=O InChI=1S/C20H25N5O3S/c1-12(2)15-11-24(10-13-5-7-14(8-6-13)29(21,27)28)19-22-17(16-9-20(16,3)4)23-25(19)18(15)26/h5-8,11-12,16H,9-10H2,1-4H3,(H2,21,27,28) LHWWJZRSYGKVIF-UHFFFAOYSA-N 114390 US20260001886, Compound 35 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 20.0 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114390&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2552154 252663896 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131403 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc([C@H]3CC3(C)C)nn2c1=O InChI=1S/C20H25N5O3S/c1-12(2)15-11-24(10-13-5-7-14(8-6-13)29(21,27)28)19-22-17(16-9-20(16,3)4)23-25(19)18(15)26/h5-8,11-12,16H,9-10H2,1-4H3,(H2,21,27,28) LHWWJZRSYGKVIF-UHFFFAOYSA-N 114390 US20260001886, Compound 35 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 5.01 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114390&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2552154 252663896 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131404 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc([C@H]3CC3(C)C)nn2c1=O InChI=1S/C20H25N5O3S/c1-12(2)15-11-24(10-13-5-7-14(8-6-13)29(21,27)28)19-22-17(16-9-20(16,3)4)23-25(19)18(15)26/h5-8,11-12,16H,9-10H2,1-4H3,(H2,21,27,28) LHWWJZRSYGKVIF-UHFFFAOYSA-N 114390 US20260001886, Compound 35 Carbonic anhydrase 2 Homo sapiens 158 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114390&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2552154 252663896 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131405 CC(C)c1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc([C@H]3CC3(C)C)nn2c1=O InChI=1S/C20H25N5O3S/c1-12(2)15-11-24(10-13-5-7-14(8-6-13)29(21,27)28)19-22-17(16-9-20(16,3)4)23-25(19)18(15)26/h5-8,11-12,16H,9-10H2,1-4H3,(H2,21,27,28) LHWWJZRSYGKVIF-UHFFFAOYSA-N 114390 US20260001886, Compound 35 Carbonic anhydrase 1 Homo sapiens 316 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114390 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114390&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2552154 252663896 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131406 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2nc(C(F)(F)F)nn2c1=O InChI=1S/C16H21F3N6O3S/c1-8(2)12-7-23(15-21-14(16(17,18)19)22-25(15)13(12)26)5-9-3-11-4-10(9)6-24(11)29(20,27)28/h7-11H,3-6H2,1-2H3,(H2,20,27,28) QRSKZWGRDHUBFB-UHFFFAOYSA-N 114391 US20260001886, Compound 36 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 50.1 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114391&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2371304 252663897 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131407 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2nc(C(F)(F)F)nn2c1=O InChI=1S/C16H21F3N6O3S/c1-8(2)12-7-23(15-21-14(16(17,18)19)22-25(15)13(12)26)5-9-3-11-4-10(9)6-24(11)29(20,27)28/h7-11H,3-6H2,1-2H3,(H2,20,27,28) QRSKZWGRDHUBFB-UHFFFAOYSA-N 114391 US20260001886, Compound 36 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 10.0 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114391&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2371304 252663897 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131408 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2nc(C(F)(F)F)nn2c1=O InChI=1S/C16H21F3N6O3S/c1-8(2)12-7-23(15-21-14(16(17,18)19)22-25(15)13(12)26)5-9-3-11-4-10(9)6-24(11)29(20,27)28/h7-11H,3-6H2,1-2H3,(H2,20,27,28) QRSKZWGRDHUBFB-UHFFFAOYSA-N 114391 US20260001886, Compound 36 Carbonic anhydrase 2 Homo sapiens 50119 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114391&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2371304 252663897 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131409 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2nc(C(F)(F)F)nn2c1=O InChI=1S/C16H21F3N6O3S/c1-8(2)12-7-23(15-21-14(16(17,18)19)22-25(15)13(12)26)5-9-3-11-4-10(9)6-24(11)29(20,27)28/h7-11H,3-6H2,1-2H3,(H2,20,27,28) QRSKZWGRDHUBFB-UHFFFAOYSA-N 114391 US20260001886, Compound 36 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114391 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114391&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2371304 252663897 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131410 CC(C)c1cn(C[C@@H]2C[C@@H]3C[C@H]2CN3S(N)(=O)=O)c2ncnn2c1=O InChI=1S/C15H22N6O3S/c1-9(2)13-7-19(15-17-8-18-21(15)14(13)22)5-10-3-12-4-11(10)6-20(12)25(16,23)24/h7-12H,3-6H2,1-2H3,(H2,16,23,24) DTHJKFLQKGZKPO-UHFFFAOYSA-N 114392 US20260001886, Compound 37 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 631 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114392&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search A1A5C 7HCH 2384232 252663898 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131411 CC(C)c1cn(C[C@@H]2C[C@@H]3C[C@H]2CN3S(N)(=O)=O)c2ncnn2c1=O InChI=1S/C15H22N6O3S/c1-9(2)13-7-19(15-17-8-18-21(15)14(13)22)5-10-3-12-4-11(10)6-20(12)25(16,23)24/h7-12H,3-6H2,1-2H3,(H2,16,23,24) DTHJKFLQKGZKPO-UHFFFAOYSA-N 114392 US20260001886, Compound 37 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 398 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114392&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search A1A5C 7HCH 2384232 252663898 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131412 CC(C)c1cn(C[C@@H]2C[C@@H]3C[C@H]2CN3S(N)(=O)=O)c2ncnn2c1=O InChI=1S/C15H22N6O3S/c1-9(2)13-7-19(15-17-8-18-21(15)14(13)22)5-10-3-12-4-11(10)6-20(12)25(16,23)24/h7-12H,3-6H2,1-2H3,(H2,16,23,24) DTHJKFLQKGZKPO-UHFFFAOYSA-N 114392 US20260001886, Compound 37 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114392&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search A1A5C 7HCH 2384232 252663898 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131413 CC(C)c1cn(C[C@@H]2C[C@@H]3C[C@H]2CN3S(N)(=O)=O)c2ncnn2c1=O InChI=1S/C15H22N6O3S/c1-9(2)13-7-19(15-17-8-18-21(15)14(13)22)5-10-3-12-4-11(10)6-20(12)25(16,23)24/h7-12H,3-6H2,1-2H3,(H2,16,23,24) DTHJKFLQKGZKPO-UHFFFAOYSA-N 114392 US20260001886, Compound 37 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114392 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114392&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search A1A5C 7HCH 2384232 252663898 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131414 Cc1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C16H17N5O3S/c1-10-8-20(9-11-2-6-13(7-3-11)25(17,23)24)16-18-14(12-4-5-12)19-21(16)15(10)22/h2-3,6-8,12H,4-5,9H2,1H3,(H2,17,23,24) MTCOKLAASUTFBW-UHFFFAOYSA-N 114393 US20260001886, Compound 38 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 15.8 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114393&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 5198374 252663899 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131415 Cc1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C16H17N5O3S/c1-10-8-20(9-11-2-6-13(7-3-11)25(17,23)24)16-18-14(12-4-5-12)19-21(16)15(10)22/h2-3,6-8,12H,4-5,9H2,1H3,(H2,17,23,24) MTCOKLAASUTFBW-UHFFFAOYSA-N 114393 US20260001886, Compound 38 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.51 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114393&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 5198374 252663899 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131416 Cc1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C16H17N5O3S/c1-10-8-20(9-11-2-6-13(7-3-11)25(17,23)24)16-18-14(12-4-5-12)19-21(16)15(10)22/h2-3,6-8,12H,4-5,9H2,1H3,(H2,17,23,24) MTCOKLAASUTFBW-UHFFFAOYSA-N 114393 US20260001886, Compound 38 Carbonic anhydrase 2 Homo sapiens 398 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114393&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 5198374 252663899 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131417 Cc1cn(Cc2ccc(S(N)(=O)=O)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C16H17N5O3S/c1-10-8-20(9-11-2-6-13(7-3-11)25(17,23)24)16-18-14(12-4-5-12)19-21(16)15(10)22/h2-3,6-8,12H,4-5,9H2,1H3,(H2,17,23,24) MTCOKLAASUTFBW-UHFFFAOYSA-N 114393 US20260001886, Compound 38 Carbonic anhydrase 1 Homo sapiens 794 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114393 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114393&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 5198374 252663899 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131418 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c3c(nn2c1=O)CCCC3 InChI=1S/C20H29N5O3S/c1-12(2)17-11-23(9-13-7-15-8-14(13)10-24(15)29(21,27)28)19-16-5-3-4-6-18(16)22-25(19)20(17)26/h11-15H,3-10H2,1-2H3,(H2,21,27,28) IHARCVFIFDXBGH-UHFFFAOYSA-N 114394 US20260001886, Compound 39 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.158 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114394&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 4648816 252663900 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131419 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c3c(nn2c1=O)CCCC3 InChI=1S/C20H29N5O3S/c1-12(2)17-11-23(9-13-7-15-8-14(13)10-24(15)29(21,27)28)19-16-5-3-4-6-18(16)22-25(19)20(17)26/h11-15H,3-10H2,1-2H3,(H2,21,27,28) IHARCVFIFDXBGH-UHFFFAOYSA-N 114394 US20260001886, Compound 39 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.631 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114394&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 4648816 252663900 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131420 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c3c(nn2c1=O)CCCC3 InChI=1S/C20H29N5O3S/c1-12(2)17-11-23(9-13-7-15-8-14(13)10-24(15)29(21,27)28)19-16-5-3-4-6-18(16)22-25(19)20(17)26/h11-15H,3-10H2,1-2H3,(H2,21,27,28) IHARCVFIFDXBGH-UHFFFAOYSA-N 114394 US20260001886, Compound 39 Carbonic anhydrase 2 Homo sapiens 79433 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114394&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 4648816 252663900 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131421 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c3c(nn2c1=O)CCCC3 InChI=1S/C20H29N5O3S/c1-12(2)17-11-23(9-13-7-15-8-14(13)10-24(15)29(21,27)28)19-16-5-3-4-6-18(16)22-25(19)20(17)26/h11-15H,3-10H2,1-2H3,(H2,21,27,28) IHARCVFIFDXBGH-UHFFFAOYSA-N 114394 US20260001886, Compound 39 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114394 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114394&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 4648816 252663900 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131422 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2c3c(nn2c1=O)COC3 InChI=1S/C19H22N4O3S/c1-12(2)15-9-22(8-13-4-6-14(7-5-13)27(3,20)25)18-16-10-26-11-17(16)21-23(18)19(15)24/h4-7,9,12,20H,8,10-11H2,1-3H3 NCTUMHFRAVDPJN-UHFFFAOYSA-N 114396 US20260001886, Compound 40 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114396&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 5008348 252663902 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131423 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2c3c(nn2c1=O)COC3 InChI=1S/C19H22N4O3S/c1-12(2)15-9-22(8-13-4-6-14(7-5-13)27(3,20)25)18-16-10-26-11-17(16)21-23(18)19(15)24/h4-7,9,12,20H,8,10-11H2,1-3H3 NCTUMHFRAVDPJN-UHFFFAOYSA-N 114396 US20260001886, Compound 40 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.398 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114396&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 5008348 252663902 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131424 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2c3c(nn2c1=O)COC3 InChI=1S/C19H22N4O3S/c1-12(2)15-9-22(8-13-4-6-14(7-5-13)27(3,20)25)18-16-10-26-11-17(16)21-23(18)19(15)24/h4-7,9,12,20H,8,10-11H2,1-3H3 NCTUMHFRAVDPJN-UHFFFAOYSA-N 114396 US20260001886, Compound 40 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114396&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 5008348 252663902 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131425 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2c3c(nn2c1=O)COC3 InChI=1S/C19H22N4O3S/c1-12(2)15-9-22(8-13-4-6-14(7-5-13)27(3,20)25)18-16-10-26-11-17(16)21-23(18)19(15)24/h4-7,9,12,20H,8,10-11H2,1-3H3 NCTUMHFRAVDPJN-UHFFFAOYSA-N 114396 US20260001886, Compound 40 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114396 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114396&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 5008348 252663902 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131426 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c3cccnc3nn2c1=O InChI=1S/C19H24N6O3S/c1-11(2)16-10-23(8-12-6-14-7-13(12)9-24(14)29(20,27)28)18-15-4-3-5-21-17(15)22-25(18)19(16)26/h3-5,10-14H,6-9H2,1-2H3,(H2,20,27,28) JAXAPXAYSCJIRH-UHFFFAOYSA-N 114397 US20260001886, Compound 41 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114397&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3279901 252663903 C02847 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131427 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c3cccnc3nn2c1=O InChI=1S/C19H24N6O3S/c1-11(2)16-10-23(8-12-6-14-7-13(12)9-24(14)29(20,27)28)18-15-4-3-5-21-17(15)22-25(18)19(16)26/h3-5,10-14H,6-9H2,1-2H3,(H2,20,27,28) JAXAPXAYSCJIRH-UHFFFAOYSA-N 114397 US20260001886, Compound 41 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114397&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3279901 252663903 C02847 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131428 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c3cccnc3nn2c1=O InChI=1S/C19H24N6O3S/c1-11(2)16-10-23(8-12-6-14-7-13(12)9-24(14)29(20,27)28)18-15-4-3-5-21-17(15)22-25(18)19(16)26/h3-5,10-14H,6-9H2,1-2H3,(H2,20,27,28) JAXAPXAYSCJIRH-UHFFFAOYSA-N 114397 US20260001886, Compound 41 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114397&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3279901 252663903 C02847 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131429 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c3cccnc3nn2c1=O InChI=1S/C19H24N6O3S/c1-11(2)16-10-23(8-12-6-14-7-13(12)9-24(14)29(20,27)28)18-15-4-3-5-21-17(15)22-25(18)19(16)26/h3-5,10-14H,6-9H2,1-2H3,(H2,20,27,28) JAXAPXAYSCJIRH-UHFFFAOYSA-N 114397 US20260001886, Compound 41 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114397 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114397&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 3279901 252663903 C02847 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131430 COc1cccc2c1nn1c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c21 InChI=1S/C21H27N5O4S/c1-12(2)17-11-24(9-13-7-15-8-14(13)10-25(15)31(22,28)29)20-16-5-4-6-18(30-3)19(16)23-26(20)21(17)27/h4-6,11-15H,7-10H2,1-3H3,(H2,22,28,29) NOWSSQBIBBKFPP-UHFFFAOYSA-N 114398 US20260001886, Compound 42 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.794 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114398 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114398&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 724891 252663904 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131431 COc1cccc2c1nn1c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c21 InChI=1S/C21H27N5O4S/c1-12(2)17-11-24(9-13-7-15-8-14(13)10-25(15)31(22,28)29)20-16-5-4-6-18(30-3)19(16)23-26(20)21(17)27/h4-6,11-15H,7-10H2,1-3H3,(H2,22,28,29) NOWSSQBIBBKFPP-UHFFFAOYSA-N 114398 US20260001886, Compound 42 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114398 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114398&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 724891 252663904 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131432 COc1cccc2c1nn1c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c21 InChI=1S/C21H27N5O4S/c1-12(2)17-11-24(9-13-7-15-8-14(13)10-25(15)31(22,28)29)20-16-5-4-6-18(30-3)19(16)23-26(20)21(17)27/h4-6,11-15H,7-10H2,1-3H3,(H2,22,28,29) NOWSSQBIBBKFPP-UHFFFAOYSA-N 114398 US20260001886, Compound 42 Carbonic anhydrase 2 Homo sapiens 31623 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114398 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114398&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 724891 252663904 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131433 COc1cccc2c1nn1c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c21 InChI=1S/C21H27N5O4S/c1-12(2)17-11-24(9-13-7-15-8-14(13)10-25(15)31(22,28)29)20-16-5-4-6-18(30-3)19(16)23-26(20)21(17)27/h4-6,11-15H,7-10H2,1-3H3,(H2,22,28,29) NOWSSQBIBBKFPP-UHFFFAOYSA-N 114398 US20260001886, Compound 42 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114398 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114398&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 724891 252663904 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131434 CC(C)c1nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c2c1F InChI=1S/C19H28FN5O3S/c1-10(2)15-9-23(18-16(20)17(11(3)4)22-25(18)19(15)26)7-12-5-14-6-13(12)8-24(14)29(21,27)28/h9-14H,5-8H2,1-4H3,(H2,21,27,28) AKOLKEZASVVOMJ-UHFFFAOYSA-N 114399 US20260001886, Compound 43 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.98 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114399 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114399&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899717 252663905 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131435 CC(C)c1nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c2c1F InChI=1S/C19H28FN5O3S/c1-10(2)15-9-23(18-16(20)17(11(3)4)22-25(18)19(15)26)7-12-5-14-6-13(12)8-24(14)29(21,27)28/h9-14H,5-8H2,1-4H3,(H2,21,27,28) AKOLKEZASVVOMJ-UHFFFAOYSA-N 114399 US20260001886, Compound 43 Carbonic anhydrase 2 Homo sapiens 15849 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114399 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114399&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 91899717 252663905 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131436 CC(C)c1nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c2c1F InChI=1S/C19H28FN5O3S/c1-10(2)15-9-23(18-16(20)17(11(3)4)22-25(18)19(15)26)7-12-5-14-6-13(12)8-24(14)29(21,27)28/h9-14H,5-8H2,1-4H3,(H2,21,27,28) AKOLKEZASVVOMJ-UHFFFAOYSA-N 114399 US20260001886, Compound 43 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114399 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114399&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 91899717 252663905 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131437 COc1c(C2CC2)nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c12 InChI=1S/C20H29N5O4S/c1-11(2)16-10-23(8-13-6-15-7-14(13)9-24(15)30(21,27)28)19-18(29-3)17(12-4-5-12)22-25(19)20(16)26/h10-15H,4-9H2,1-3H3,(H2,21,27,28) KKMRVPQOJNJMJZ-UHFFFAOYSA-N 114400 US20260001886, Compound 44 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 5.01 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114400 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114400&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899718 252663906 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131438 COc1c(C2CC2)nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c12 InChI=1S/C20H29N5O4S/c1-11(2)16-10-23(8-13-6-15-7-14(13)9-24(15)30(21,27)28)19-18(29-3)17(12-4-5-12)22-25(19)20(16)26/h10-15H,4-9H2,1-3H3,(H2,21,27,28) KKMRVPQOJNJMJZ-UHFFFAOYSA-N 114400 US20260001886, Compound 44 Carbonic anhydrase 2 Homo sapiens 63096 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114400 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114400&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 91899718 252663906 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131439 COc1c(C2CC2)nn2c(=O)c(C(C)C)cn(C[C@H]3C[C@H]4C[C@@H]3CN4S(N)(=O)=O)c12 InChI=1S/C20H29N5O4S/c1-11(2)16-10-23(8-13-6-15-7-14(13)9-24(15)30(21,27)28)19-18(29-3)17(12-4-5-12)22-25(19)20(16)26/h10-15H,4-9H2,1-3H3,(H2,21,27,28) KKMRVPQOJNJMJZ-UHFFFAOYSA-N 114400 US20260001886, Compound 44 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114400 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114400&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 91899718 252663906 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131440 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c(C#N)c(C3CC3)nn2c1=O InChI=1S/C20H26N6O3S/c1-11(2)17-10-24(8-13-5-15-6-14(13)9-25(15)30(22,28)29)19-16(7-21)18(12-3-4-12)23-26(19)20(17)27/h10-15H,3-6,8-9H2,1-2H3,(H2,22,28,29) FSPHCBXZERJLQR-UHFFFAOYSA-N 114401 US20260001886, Compound 45 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114401 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114401&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 647243 252663907 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131441 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c(C#N)c(C3CC3)nn2c1=O InChI=1S/C20H26N6O3S/c1-11(2)17-10-24(8-13-5-15-6-14(13)9-25(15)30(22,28)29)19-16(7-21)18(12-3-4-12)23-26(19)20(17)27/h10-15H,3-6,8-9H2,1-2H3,(H2,22,28,29) FSPHCBXZERJLQR-UHFFFAOYSA-N 114401 US20260001886, Compound 45 Carbonic anhydrase 2 Homo sapiens 39811 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114401 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114401&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 647243 252663907 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131442 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(N)(=O)=O)c2c(C#N)c(C3CC3)nn2c1=O InChI=1S/C20H26N6O3S/c1-11(2)17-10-24(8-13-5-15-6-14(13)9-25(15)30(22,28)29)19-16(7-21)18(12-3-4-12)23-26(19)20(17)27/h10-15H,3-6,8-9H2,1-2H3,(H2,22,28,29) FSPHCBXZERJLQR-UHFFFAOYSA-N 114401 US20260001886, Compound 45 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114401 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114401&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 647243 252663907 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131443 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(C)(=N)=O)c2cc(OC(F)(F)F)nn2c1=O InChI=1S/C18H24F3N5O3S/c1-10(2)14-9-24(7-11-4-13-5-12(11)8-25(13)30(3,22)28)16-6-15(29-18(19,20)21)23-26(16)17(14)27/h6,9-13,22H,4-5,7-8H2,1-3H3 WXKKAQFPPZTUKX-UHFFFAOYSA-N 114402 US20260001886, Compound 46 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.631 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114402 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114402&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 651643 252663908 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131444 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(C)(=N)=O)c2cc(OC(F)(F)F)nn2c1=O InChI=1S/C18H24F3N5O3S/c1-10(2)14-9-24(7-11-4-13-5-12(11)8-25(13)30(3,22)28)16-6-15(29-18(19,20)21)23-26(16)17(14)27/h6,9-13,22H,4-5,7-8H2,1-3H3 WXKKAQFPPZTUKX-UHFFFAOYSA-N 114402 US20260001886, Compound 46 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114402 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114402&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 651643 252663908 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131445 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(C)(=N)=O)c2cc(OC(F)(F)F)nn2c1=O InChI=1S/C18H24F3N5O3S/c1-10(2)14-9-24(7-11-4-13-5-12(11)8-25(13)30(3,22)28)16-6-15(29-18(19,20)21)23-26(16)17(14)27/h6,9-13,22H,4-5,7-8H2,1-3H3 WXKKAQFPPZTUKX-UHFFFAOYSA-N 114402 US20260001886, Compound 46 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114402 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114402&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 651643 252663908 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131446 CC(C)c1cn(C[C@H]2C[C@H]3C[C@@H]2CN3S(C)(=N)=O)c2cc(OC(F)(F)F)nn2c1=O InChI=1S/C18H24F3N5O3S/c1-10(2)14-9-24(7-11-4-13-5-12(11)8-25(13)30(3,22)28)16-6-15(29-18(19,20)21)23-26(16)17(14)27/h6,9-13,22H,4-5,7-8H2,1-3H3 WXKKAQFPPZTUKX-UHFFFAOYSA-N 114402 US20260001886, Compound 46 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114402 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114402&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 651643 252663908 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131447 Cc1c(C2CC2)nn2c(=O)c(C(C)C)cn(Cc3ccc([S@@](C)(=N)=O)cc3)c12 InChI=1S/C21H26N4O2S/c1-13(2)18-12-24(11-15-5-9-17(10-6-15)28(4,22)27)20-14(3)19(16-7-8-16)23-25(20)21(18)26/h5-6,9-10,12-13,16,22H,7-8,11H2,1-4H3 SEWIZKSRZLBIHS-UHFFFAOYSA-N 114404 US20260001886, Compound 47 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114404&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899719 252663909 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131448 Cc1c(C2CC2)nn2c(=O)c(C(C)C)cn(Cc3ccc([S@@](C)(=N)=O)cc3)c12 InChI=1S/C21H26N4O2S/c1-13(2)18-12-24(11-15-5-9-17(10-6-15)28(4,22)27)20-14(3)19(16-7-8-16)23-25(20)21(18)26/h5-6,9-10,12-13,16,22H,7-8,11H2,1-4H3 SEWIZKSRZLBIHS-UHFFFAOYSA-N 114404 US20260001886, Compound 47 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114404&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899719 252663909 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131449 Cc1c(C2CC2)nn2c(=O)c(C(C)C)cn(Cc3ccc([S@@](C)(=N)=O)cc3)c12 InChI=1S/C21H26N4O2S/c1-13(2)18-12-24(11-15-5-9-17(10-6-15)28(4,22)27)20-14(3)19(16-7-8-16)23-25(20)21(18)26/h5-6,9-10,12-13,16,22H,7-8,11H2,1-4H3 SEWIZKSRZLBIHS-UHFFFAOYSA-N 114404 US20260001886, Compound 47 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114404&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 91899719 252663909 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131450 Cc1c(C2CC2)nn2c(=O)c(C(C)C)cn(Cc3ccc([S@@](C)(=N)=O)cc3)c12 InChI=1S/C21H26N4O2S/c1-13(2)18-12-24(11-15-5-9-17(10-6-15)28(4,22)27)20-14(3)19(16-7-8-16)23-25(20)21(18)26/h5-6,9-10,12-13,16,22H,7-8,11H2,1-4H3 SEWIZKSRZLBIHS-UHFFFAOYSA-N 114404 US20260001886, Compound 47 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114404 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114404&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 91899719 252663909 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131451 CC(C)c1cn(Cc2ccc3c(c2)CCS3(=N)=O)c2nc(C3CC3)nn2c1=O InChI=1S/C20H23N5O2S/c1-12(2)16-11-24(20-22-18(14-4-5-14)23-25(20)19(16)26)10-13-3-6-17-15(9-13)7-8-28(17,21)27/h3,6,9,11-12,14,21H,4-5,7-8,10H2,1-2H3 SXJQNARPIFEVGQ-UHFFFAOYSA-N 114405 US20260001886, Compound 48 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 31.6 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114405 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114405&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 645511 252663910 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131452 CC(C)c1cn(Cc2ccc(S(=N)(=O)C(F)(F)F)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H20F3N5O2S/c1-11(2)15-10-26(18-24-16(13-5-6-13)25-27(18)17(15)28)9-12-3-7-14(8-4-12)30(23,29)19(20,21)22/h3-4,7-8,10-11,13,23H,5-6,9H2,1-2H3 IJUOYKZWSHLQEC-UHFFFAOYSA-N 114406 US20260001886, Compound 49 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114406&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2742889 252663911 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131453 CC(C)c1cn(Cc2ccc(S(=N)(=O)C(F)(F)F)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H20F3N5O2S/c1-11(2)15-10-26(18-24-16(13-5-6-13)25-27(18)17(15)28)9-12-3-7-14(8-4-12)30(23,29)19(20,21)22/h3-4,7-8,10-11,13,23H,5-6,9H2,1-2H3 IJUOYKZWSHLQEC-UHFFFAOYSA-N 114406 US20260001886, Compound 49 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114406&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2742889 252663911 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131454 CC(C)c1cn(Cc2ccc(S(=N)(=O)C(F)(F)F)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H20F3N5O2S/c1-11(2)15-10-26(18-24-16(13-5-6-13)25-27(18)17(15)28)9-12-3-7-14(8-4-12)30(23,29)19(20,21)22/h3-4,7-8,10-11,13,23H,5-6,9H2,1-2H3 IJUOYKZWSHLQEC-UHFFFAOYSA-N 114406 US20260001886, Compound 49 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114406&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2742889 252663911 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131455 CC(C)c1cn(Cc2ccc(S(=N)(=O)C(F)(F)F)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H20F3N5O2S/c1-11(2)15-10-26(18-24-16(13-5-6-13)25-27(18)17(15)28)9-12-3-7-14(8-4-12)30(23,29)19(20,21)22/h3-4,7-8,10-11,13,23H,5-6,9H2,1-2H3 IJUOYKZWSHLQEC-UHFFFAOYSA-N 114406 US20260001886, Compound 49 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114406 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114406&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2742889 252663911 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131456 CC(C)c1cn(Cc2ccc(S(=N)(=O)C(F)F)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H21F2N5O2S/c1-11(2)15-10-25(19-23-16(13-5-6-13)24-26(19)17(15)27)9-12-3-7-14(8-4-12)29(22,28)18(20)21/h3-4,7-8,10-11,13,18,22H,5-6,9H2,1-2H3 FQQYDPCGLBUNDM-UHFFFAOYSA-N 114407 US20260001886, Compound 50 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 31.6 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114407 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114407&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2823604 252663912 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131457 [2H]C([2H])([2H])[S@@](=N)(=O)c1ccc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)cc1 InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3/i3D3 JUSQJQAEDDMPMS-HPRDVNIFSA-N 114409 US20260001886, Compound 51 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114409&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 899350 252663914 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131458 [2H]C([2H])([2H])[S@@](=N)(=O)c1ccc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)cc1 InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3/i3D3 JUSQJQAEDDMPMS-HPRDVNIFSA-N 114409 US20260001886, Compound 51 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.398 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114409&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 899350 252663914 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131459 [2H]C([2H])([2H])[S@@](=N)(=O)c1ccc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)cc1 InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3/i3D3 JUSQJQAEDDMPMS-HPRDVNIFSA-N 114409 US20260001886, Compound 51 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114409&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 899350 252663914 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131460 [2H]C([2H])([2H])[S@@](=N)(=O)c1ccc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)cc1 InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(10-13-4-8-15(9-5-13)27(3,20)26)19-21-17(14-6-7-14)22-24(19)18(16)25/h4-5,8-9,11-12,14,20H,6-7,10H2,1-3H3/i3D3 JUSQJQAEDDMPMS-HPRDVNIFSA-N 114409 US20260001886, Compound 51 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114409 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114409&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 899350 252663914 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131461 Cc1nc2n(Cc3ccc4c(c3)CCCS4(=N)=O)cc(C(C)C)c(=O)n2n1 InChI=1S/C19H23N5O2S/c1-12(2)16-11-23(19-21-13(3)22-24(19)18(16)25)10-14-6-7-17-15(9-14)5-4-8-27(17,20)26/h6-7,9,11-12,20H,4-5,8,10H2,1-3H3 VOCGXVKOJONOSH-UHFFFAOYSA-N 114410 US20260001886, Compound 52 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 126 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114410 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114410&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 24746879 252663915 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131462 CC(C)c1cn(Cc2ccc3c(c2)OCCS3(=N)=O)c2nc(C3CC3)nn2c1=O InChI=1S/C20H23N5O3S/c1-12(2)15-11-24(20-22-18(14-4-5-14)23-25(20)19(15)26)10-13-3-6-17-16(9-13)28-7-8-29(17,21)27/h3,6,9,11-12,14,21H,4-5,7-8,10H2,1-2H3 VHFVMYCUCKEJMP-UHFFFAOYSA-N 114411 US20260001886, Compound 53 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 100 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114411 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114411&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3115457 252663916 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131463 CC(C)c1cn(Cc2ccc(S(=N)(=O)C3CC3)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C21H25N5O2S/c1-13(2)18-12-25(21-23-19(15-5-6-15)24-26(21)20(18)27)11-14-3-7-16(8-4-14)29(22,28)17-9-10-17/h3-4,7-8,12-13,15,17,22H,5-6,9-11H2,1-2H3 OYCMOVSCCLVBDO-UHFFFAOYSA-N 114412 US20260001886, Compound 54 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114412 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114412&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1082733 252663917 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131464 CC(C)c1cn(Cc2ccc([S@@](=N)(=O)C3CC3)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C21H25N5O2S/c1-13(2)18-12-25(21-23-19(15-5-6-15)24-26(21)20(18)27)11-14-3-7-16(8-4-14)29(22,28)17-9-10-17/h3-4,7-8,12-13,15,17,22H,5-6,9-11H2,1-2H3 OYCMOVSCCLVBDO-UHFFFAOYSA-N 114413 US20260001886, Compound 55 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.316 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114413 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114413&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 929513 252663918 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131465 CCS(=N)(=O)c1ccc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)cc1 InChI=1S/C20H25N5O2S/c1-4-28(21,27)16-9-5-14(6-10-16)11-24-12-17(13(2)3)19(26)25-20(24)22-18(23-25)15-7-8-15/h5-6,9-10,12-13,15,21H,4,7-8,11H2,1-3H3 YYZRZGFNMFQIBV-UHFFFAOYSA-N 114414 US20260001886, Compound 56 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.51 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114414&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1451421 252663919 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131466 CCS(=N)(=O)c1ccc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)cc1 InChI=1S/C20H25N5O2S/c1-4-28(21,27)16-9-5-14(6-10-16)11-24-12-17(13(2)3)19(26)25-20(24)22-18(23-25)15-7-8-15/h5-6,9-10,12-13,15,21H,4,7-8,11H2,1-3H3 YYZRZGFNMFQIBV-UHFFFAOYSA-N 114414 US20260001886, Compound 56 Carbonic anhydrase 2 Homo sapiens 31623 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114414&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1451421 252663919 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131467 CCS(=N)(=O)c1ccc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)cc1 InChI=1S/C20H25N5O2S/c1-4-28(21,27)16-9-5-14(6-10-16)11-24-12-17(13(2)3)19(26)25-20(24)22-18(23-25)15-7-8-15/h5-6,9-10,12-13,15,21H,4,7-8,11H2,1-3H3 YYZRZGFNMFQIBV-UHFFFAOYSA-N 114414 US20260001886, Compound 56 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114414 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114414&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1451421 252663919 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131468 CC[S@](=N)(=O)c1ccc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)cc1 InChI=1S/C20H25N5O2S/c1-4-28(21,27)16-9-5-14(6-10-16)11-24-12-17(13(2)3)19(26)25-20(24)22-18(23-25)15-7-8-15/h5-6,9-10,12-13,15,21H,4,7-8,11H2,1-3H3 YYZRZGFNMFQIBV-UHFFFAOYSA-N 114415 US20260001886, Compound 56A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114415 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114415&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3153154 252663920 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131469 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 114416 US20260001886, Compound 57 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114416&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1181832 252663921 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131470 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 114416 US20260001886, Compound 57 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.631 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114416&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1181832 252663921 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131471 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 114416 US20260001886, Compound 57 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114416&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1181832 252663921 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131472 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H24N4O2S/c1-13(2)17-12-23(11-14-4-8-16(9-5-14)27(3,21)26)19-10-18(15-6-7-15)22-24(19)20(17)25/h4-5,8-10,12-13,15,21H,6-7,11H2,1-3H3 KHVSBZAUYJEZKX-UHFFFAOYSA-N 114416 US20260001886, Compound 57 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114416 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114416&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1181832 252663921 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131473 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)cc23)ccc1S(C)(=N)=O InChI=1S/C21H26N4O2S/c1-13(2)17-12-24(11-15-5-8-19(14(3)9-15)28(4,22)27)20-10-18(16-6-7-16)23-25(20)21(17)26/h5,8-10,12-13,16,22H,6-7,11H2,1-4H3 ZWYMAVKWFCTEKO-UHFFFAOYSA-N 114417 US20260001886, Compound 58 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.00 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114417&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 995260 252663922 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131474 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)cc23)ccc1S(C)(=N)=O InChI=1S/C21H26N4O2S/c1-13(2)17-12-24(11-15-5-8-19(14(3)9-15)28(4,22)27)20-10-18(16-6-7-16)23-25(20)21(17)26/h5,8-10,12-13,16,22H,6-7,11H2,1-4H3 ZWYMAVKWFCTEKO-UHFFFAOYSA-N 114417 US20260001886, Compound 58 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114417&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 995260 252663922 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131475 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)cc23)ccc1S(C)(=N)=O InChI=1S/C21H26N4O2S/c1-13(2)17-12-24(11-15-5-8-19(14(3)9-15)28(4,22)27)20-10-18(16-6-7-16)23-25(20)21(17)26/h5,8-10,12-13,16,22H,6-7,11H2,1-4H3 ZWYMAVKWFCTEKO-UHFFFAOYSA-N 114417 US20260001886, Compound 58 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114417 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114417&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 995260 252663922 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131476 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)cc23)ccc1[S@@](C)(=N)=O InChI=1S/C21H26N4O2S/c1-13(2)17-12-24(11-15-5-8-19(14(3)9-15)28(4,22)27)20-10-18(16-6-7-16)23-25(20)21(17)26/h5,8-10,12-13,16,22H,6-7,11H2,1-4H3 ZWYMAVKWFCTEKO-UHFFFAOYSA-N 114418 US20260001886, Compound 58A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114418 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114418&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 865075 252663923 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131477 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(C(F)(F)F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C20H22F3N5O2S/c1-11(2)14-10-27(19-25-17(13-5-6-13)26-28(19)18(14)29)9-12-4-7-16(31(3,24)30)15(8-12)20(21,22)23/h4,7-8,10-11,13,24H,5-6,9H2,1-3H3 QTOMIEZSACPHJL-UHFFFAOYSA-N 114419 US20260001886, Compound 59 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114419&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3705005 252663924 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131478 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(C(F)(F)F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C20H22F3N5O2S/c1-11(2)14-10-27(19-25-17(13-5-6-13)26-28(19)18(14)29)9-12-4-7-16(31(3,24)30)15(8-12)20(21,22)23/h4,7-8,10-11,13,24H,5-6,9H2,1-3H3 QTOMIEZSACPHJL-UHFFFAOYSA-N 114419 US20260001886, Compound 59 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114419&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 3705005 252663924 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131479 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(C(F)(F)F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C20H22F3N5O2S/c1-11(2)14-10-27(19-25-17(13-5-6-13)26-28(19)18(14)29)9-12-4-7-16(31(3,24)30)15(8-12)20(21,22)23/h4,7-8,10-11,13,24H,5-6,9H2,1-3H3 QTOMIEZSACPHJL-UHFFFAOYSA-N 114419 US20260001886, Compound 59 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114419&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 3705005 252663924 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131480 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(C(F)(F)F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C20H22F3N5O2S/c1-11(2)14-10-27(19-25-17(13-5-6-13)26-28(19)18(14)29)9-12-4-7-16(31(3,24)30)15(8-12)20(21,22)23/h4,7-8,10-11,13,24H,5-6,9H2,1-3H3 QTOMIEZSACPHJL-UHFFFAOYSA-N 114419 US20260001886, Compound 59 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114419 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114419&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 3705005 252663924 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131481 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)c(C(F)(F)F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C20H22F3N5O2S/c1-11(2)14-10-27(19-25-17(13-5-6-13)26-28(19)18(14)29)9-12-4-7-16(31(3,24)30)15(8-12)20(21,22)23/h4,7-8,10-11,13,24H,5-6,9H2,1-3H3 QTOMIEZSACPHJL-UHFFFAOYSA-N 114421 US20260001886, Compound 59A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 7.94 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114421&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899721 252663926 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131482 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)c(C(F)(F)F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C20H22F3N5O2S/c1-11(2)14-10-27(19-25-17(13-5-6-13)26-28(19)18(14)29)9-12-4-7-16(31(3,24)30)15(8-12)20(21,22)23/h4,7-8,10-11,13,24H,5-6,9H2,1-3H3 QTOMIEZSACPHJL-UHFFFAOYSA-N 114421 US20260001886, Compound 59A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.51 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114421&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 91899721 252663926 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131483 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)c(C(F)(F)F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C20H22F3N5O2S/c1-11(2)14-10-27(19-25-17(13-5-6-13)26-28(19)18(14)29)9-12-4-7-16(31(3,24)30)15(8-12)20(21,22)23/h4,7-8,10-11,13,24H,5-6,9H2,1-3H3 QTOMIEZSACPHJL-UHFFFAOYSA-N 114421 US20260001886, Compound 59A Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114421&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 91899721 252663926 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131484 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)c(C(F)(F)F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C20H22F3N5O2S/c1-11(2)14-10-27(19-25-17(13-5-6-13)26-28(19)18(14)29)9-12-4-7-16(31(3,24)30)15(8-12)20(21,22)23/h4,7-8,10-11,13,24H,5-6,9H2,1-3H3 QTOMIEZSACPHJL-UHFFFAOYSA-N 114421 US20260001886, Compound 59A Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114421 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114421&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 91899721 252663926 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131485 [2H]C([2H])([2H])S(=N)(=O)c4ccc(Cn2cc(C(C)C)c(=O)n3nc(C1CC1)nc23)cc4 InChI=1S/C22H29N5O2S/c1-14(2)18-13-26(21-24-19(16-8-9-16)25-27(21)20(18)28)12-15-6-10-17(11-7-15)30(23,29)22(3,4)5/h6-7,10-11,13-14,16,23H,8-9,12H2,1-5H3 YTLUFCDBOINSEC-UHFFFAOYSA-N 114422 US20260001886, Compound 60 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114422&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 20901978 252663927 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131486 [2H]C([2H])([2H])S(=N)(=O)c4ccc(Cn2cc(C(C)C)c(=O)n3nc(C1CC1)nc23)cc4 InChI=1S/C22H29N5O2S/c1-14(2)18-13-26(21-24-19(16-8-9-16)25-27(21)20(18)28)12-15-6-10-17(11-7-15)30(23,29)22(3,4)5/h6-7,10-11,13-14,16,23H,8-9,12H2,1-5H3 YTLUFCDBOINSEC-UHFFFAOYSA-N 114422 US20260001886, Compound 60 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 0.398 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114422&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 20901978 252663927 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131487 [2H]C([2H])([2H])S(=N)(=O)c4ccc(Cn2cc(C(C)C)c(=O)n3nc(C1CC1)nc23)cc4 InChI=1S/C22H29N5O2S/c1-14(2)18-13-26(21-24-19(16-8-9-16)25-27(21)20(18)28)12-15-6-10-17(11-7-15)30(23,29)22(3,4)5/h6-7,10-11,13-14,16,23H,8-9,12H2,1-5H3 YTLUFCDBOINSEC-UHFFFAOYSA-N 114422 US20260001886, Compound 60 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114422&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 20901978 252663927 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131488 [2H]C([2H])([2H])S(=N)(=O)c4ccc(Cn2cc(C(C)C)c(=O)n3nc(C1CC1)nc23)cc4 InChI=1S/C22H29N5O2S/c1-14(2)18-13-26(21-24-19(16-8-9-16)25-27(21)20(18)28)12-15-6-10-17(11-7-15)30(23,29)22(3,4)5/h6-7,10-11,13-14,16,23H,8-9,12H2,1-5H3 YTLUFCDBOINSEC-UHFFFAOYSA-N 114422 US20260001886, Compound 60 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114422 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114422&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 20901978 252663927 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131489 Cc1cc(S(C)(=N)=O)ccc1Cn1cc(C(C)C)c(=O)n2nc(C3CC3)cc12 InChI=1S/C21H26N4O2S/c1-13(2)18-12-24(11-16-7-8-17(9-14(16)3)28(4,22)27)20-10-19(15-5-6-15)23-25(20)21(18)26/h7-10,12-13,15,22H,5-6,11H2,1-4H3 PJLQGJJJGUSJAL-UHFFFAOYSA-N 114423 US20260001886, Compound 61 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.98 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114423&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 20900935 252663928 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131490 Cc1cc(S(C)(=N)=O)ccc1Cn1cc(C(C)C)c(=O)n2nc(C3CC3)cc12 InChI=1S/C21H26N4O2S/c1-13(2)18-12-24(11-16-7-8-17(9-14(16)3)28(4,22)27)20-10-19(15-5-6-15)23-25(20)21(18)26/h7-10,12-13,15,22H,5-6,11H2,1-4H3 PJLQGJJJGUSJAL-UHFFFAOYSA-N 114423 US20260001886, Compound 61 Carbonic anhydrase 2 Homo sapiens 158489 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114423&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 20900935 252663928 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131491 Cc1cc(S(C)(=N)=O)ccc1Cn1cc(C(C)C)c(=O)n2nc(C3CC3)cc12 InChI=1S/C21H26N4O2S/c1-13(2)18-12-24(11-16-7-8-17(9-14(16)3)28(4,22)27)20-10-19(15-5-6-15)23-25(20)21(18)26/h7-10,12-13,15,22H,5-6,11H2,1-4H3 PJLQGJJJGUSJAL-UHFFFAOYSA-N 114423 US20260001886, Compound 61 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114423 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114423&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 20900935 252663928 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131492 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2F)c2cc(C3CC3)nn2c1=O InChI=1S/C20H23FN4O2S/c1-12(2)16-11-24(10-14-6-7-15(8-17(14)21)28(3,22)27)19-9-18(13-4-5-13)23-25(19)20(16)26/h6-9,11-13,22H,4-5,10H2,1-3H3 YKFLTJHOKHSEBF-UHFFFAOYSA-N 114424 US20260001886, Compound 62 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114424&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442829 252663929 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131493 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2F)c2cc(C3CC3)nn2c1=O InChI=1S/C20H23FN4O2S/c1-12(2)16-11-24(10-14-6-7-15(8-17(14)21)28(3,22)27)19-9-18(13-4-5-13)23-25(19)20(16)26/h6-9,11-13,22H,4-5,10H2,1-3H3 YKFLTJHOKHSEBF-UHFFFAOYSA-N 114424 US20260001886, Compound 62 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114424&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 1442829 252663929 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131494 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2F)c2cc(C3CC3)nn2c1=O InChI=1S/C20H23FN4O2S/c1-12(2)16-11-24(10-14-6-7-15(8-17(14)21)28(3,22)27)19-9-18(13-4-5-13)23-25(19)20(16)26/h6-9,11-13,22H,4-5,10H2,1-3H3 YKFLTJHOKHSEBF-UHFFFAOYSA-N 114424 US20260001886, Compound 62 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114424 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114424&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 1442829 252663929 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131495 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)14-10-24(9-12-4-7-16(15(20)8-12)28(3,21)27)19-22-17(13-5-6-13)23-25(19)18(14)26/h4,7-8,10-11,13,21H,5-6,9H2,1-3H3 AKLBRXZNXMBLCN-UHFFFAOYSA-N 114425 US20260001886, Compound 63 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 10.0 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114425&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 24792443 252663930 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131496 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)14-10-24(9-12-4-7-16(15(20)8-12)28(3,21)27)19-22-17(13-5-6-13)23-25(19)18(14)26/h4,7-8,10-11,13,21H,5-6,9H2,1-3H3 AKLBRXZNXMBLCN-UHFFFAOYSA-N 114425 US20260001886, Compound 63 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114425&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 24792443 252663930 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131497 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)c(F)c2)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)14-10-24(9-12-4-7-16(15(20)8-12)28(3,21)27)19-22-17(13-5-6-13)23-25(19)18(14)26/h4,7-8,10-11,13,21H,5-6,9H2,1-3H3 AKLBRXZNXMBLCN-UHFFFAOYSA-N 114425 US20260001886, Compound 63 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114425 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114425&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 24792443 252663930 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131498 CC(C)c1cn(Cc2ccc(S(=N)(=O)C(C)C)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C21H27N5O2S/c1-13(2)18-12-25(21-23-19(16-7-8-16)24-26(21)20(18)27)11-15-5-9-17(10-6-15)29(22,28)14(3)4/h5-6,9-10,12-14,16,22H,7-8,11H2,1-4H3 JNDMWMXECKKONP-UHFFFAOYSA-N 114426 US20260001886, Compound 64 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 7.94 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114426 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114426&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 24792486 252663931 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131499 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1[S@](C)(=N)=O InChI=1S/C20H25N5O2S/c1-12(2)16-11-24(10-14-5-8-17(13(3)9-14)28(4,21)27)20-22-18(15-6-7-15)23-25(20)19(16)26/h5,8-9,11-12,15,21H,6-7,10H2,1-4H3 CQUIZMIQAFFVDT-UHFFFAOYSA-N 114427 US20260001886, Compound 65 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.58 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114427&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 22548306 252663932 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131500 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1[S@](C)(=N)=O InChI=1S/C20H25N5O2S/c1-12(2)16-11-24(10-14-5-8-17(13(3)9-14)28(4,21)27)20-22-18(15-6-7-15)23-25(20)19(16)26/h5,8-9,11-12,15,21H,6-7,10H2,1-4H3 CQUIZMIQAFFVDT-UHFFFAOYSA-N 114427 US20260001886, Compound 65 Carbonic anhydrase 2 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114427&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 22548306 252663932 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131501 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1[S@](C)(=N)=O InChI=1S/C20H25N5O2S/c1-12(2)16-11-24(10-14-5-8-17(13(3)9-14)28(4,21)27)20-22-18(15-6-7-15)23-25(20)19(16)26/h5,8-9,11-12,15,21H,6-7,10H2,1-4H3 CQUIZMIQAFFVDT-UHFFFAOYSA-N 114427 US20260001886, Compound 65 Carbonic anhydrase 1 Homo sapiens 1000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114427 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114427&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 22548306 252663932 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131502 Cc1cc([S@@](C)(=N)=O)ccc1Cn1cc(C(C)C)c(=O)n2nc(C3CC3)cc12 InChI=1S/C21H26N4O2S/c1-13(2)18-12-24(11-16-7-8-17(9-14(16)3)28(4,22)27)20-10-19(15-5-6-15)23-25(20)21(18)26/h7-10,12-13,15,22H,5-6,11H2,1-4H3 PJLQGJJJGUSJAL-UHFFFAOYSA-N 114428 US20260001886, Compound 66 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114428 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114428&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1301702 252663933 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131503 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)cc23)ccc1[S@@](C)(=N)=O InChI=1S/C21H26N4O2S/c1-13(2)17-12-24(11-15-5-8-19(14(3)9-15)28(4,22)27)20-10-18(16-6-7-16)23-25(20)21(17)26/h5,8-10,12-13,16,22H,6-7,11H2,1-4H3 ZWYMAVKWFCTEKO-UHFFFAOYSA-N 114429 US20260001886, Compound 67 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 1.26 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114429 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114429&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 24793479 252663934 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131504 CC(C)c1cn(Cc2ccc([S@@](=N)(=O)C(C)C)cc2)c2nc(C3CC3)nn2c1=O InChI=1S/C21H27N5O2S/c1-13(2)18-12-25(21-23-19(16-7-8-16)24-26(21)20(18)27)11-15-5-9-17(10-6-15)29(22,28)14(3)4/h5-6,9-10,12-14,16,22H,7-8,11H2,1-4H3 JNDMWMXECKKONP-UHFFFAOYSA-N 114430 US20260001886, Compound 68 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 6.31 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114430 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114430&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 1442810 252663935 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131505 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)15-10-24(9-13-6-7-14(8-16(13)20)28(3,21)27)19-22-17(12-4-5-12)23-25(19)18(15)26/h6-8,10-12,21H,4-5,9H2,1-3H3 OCEOZIJOINYLON-UHFFFAOYSA-N 114431 US20260001886, Compound 69 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.98 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114431 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114431&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2205361 252663936 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131506 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)15-10-24(9-13-6-7-14(8-16(13)20)28(3,21)27)19-22-17(12-4-5-12)23-25(19)18(15)26/h6-8,10-12,21H,4-5,9H2,1-3H3 OCEOZIJOINYLON-UHFFFAOYSA-N 114431 US20260001886, Compound 69 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114431 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114431&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 2205361 252663936 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 8ZWV,8C0Q,6EQU,9TYE,9RAY,9P0W,9OBJ,9OAM,9LR6,9LDP,9LDO,9L33,9L32,9L31,9L30,9L2Z,9L2Y,9L2X,9KJ5,9KJ4,9KJ3,9KJ2,9KJ1,9KJ0,9KIZ,9KIY,9KIX,9KIW,9KIV,9KIU,9KIT,9KIS,9KIR,9KIQ,9KIP,9KIO,9KIN,9KIM,9KIL,9KIK,9KIJ,9KII,9KIH,9KIG,9KIF,9KIE,9KID,9KIC,9KIB,9KIA,9KI9,9KI8,9KI7,9KI6,9KI5,9KI4,9KI3,9KI2,9KH8,9I29,9HXZ,9HWM,9HQG,9HQ3,9HNX,9HD6,9H0W,9H0V,9GUO,9GUM,9GU7,9GOO,9GFX,9GFW,9GFV,9GAM,9GAK,9GAJ,9G38,9FPU,9FPT,9FPS,9FPR,9FPQ,9FJV,9FJQ,9FAO,9FAI,9EN8,8WEP,8VQ7,8VQ6,8UFX,8SF1,8SD9,8SD8,8SD7,8SD6,8SD1,8SAG,8SAF,8ROW,8ROU,8RLP,8RJ2,8R2K,8R2F,8R1I,8QQA,8QKZ,8QHO,8QH8,8QFK,8QF9,8QF7,8OUB,8OTP,8OMP,8OMN,8OMH,8OMB,8OLM,8OLK,8OLI,8OKQ,8OGF,8J2O,8FQZ,8FQY,8FQX,8FAU,8FAL,8EYL,8EXG,8EXC,8EMU,8EM3,8DJ9,8CR0,8C0R,8BZZ,8BOE,8BJX,8AAE,8AA6,7ZWB,7ZL6,7YWT,7Y2X,7Y2W,7Y2V,7Y2U,7Y2T,7Y2S,7Y2R,7Y2Q,7Y2O,7Y2N,7Y2M,7Y2L,7Y2K,7Y2J,7Y2I,7Y2H,7Y2G,7Y2F,7Y2E,7Y2C,7Y2A,7RRE,7RNZ,7RNY,7R1X,7QZX,7QSI,7QSE,7QRK,7QNV,7QGZ,7QGY,7QGX,7QBH,7OYR,7OYQ,7OYP,7OYO,7OYN,7OYM,7ORQ,7ORP,7OK8,7NH8,7NH6,7K6L,7K6K,7K6J,7K6I,7JNZ,7JNX,7JNW,7JNV,7JNR,7BI5,7BHH,7BG5,7BFA,7ASJ,7AGN,7AES,7AEQ,6ZR8,6YZX,6YZW,6YZV,6YZU,6YZT,6YZS,6YZR,6YZQ,6YRI,6YQU,6YQT,6YPW,6YMB,6YMA,6XXT,6XWZ,6WQ9,6WQ8,6WQ7,6WQ5,6WQ4,6WKA,6UX1,6UFD,6UFC,6UFB,6T81,6T5C,6T4P,6T4O,6T4N,6SYS,6SYB,6SX9,6SG6,6SG0,6SFU,6SFQ,6SEY,6SDS,6SDL,6SDJ,6SDI,6SDH,6SD7,6SBM,6SBL,6SBH,6SB7,6SAY,6SAS,6SAC,6S9Z,6S9G,6RW1,6RVL,6RVK,6RVF,6RSZ,6RS5,6RRI,6RRG,6RQI,6ROE,6ROB,6RNP,6RMP,6RM1,6RL9,6RKN,6RJJ,6RIT,6RIG,6RHK,6RHJ,6RH4,6RG5,6RG4,6RG3,6RFH,6R6J,6R6F,6QEB,6PGX,6PEA,6PDV,6OTO,6OE1,6OE0,6ODZ,6LVA,6LV9,6LV8,6LV7,6LV6,6LV5,6LV4,6LV3,6LV2,6LV1,6LUZ,6LUY,6LUX,6LUW,6LUV,6LUU,6KM6,6KM5,6KM4,6KM3,6IC2,6I3E,6I2F,6I1U,6I0W,6HXD,6HX5,6HR3,6HQX,6HD2,6H3Q,6H34,6H33,6H2Z,6H29,6GOT,6GM9,6GDC,6G6T,6G3Q,6D1M,6D1L,6C7X,6C7W,6BCC,6BC9,6BBS,5YUK,5YUJ,5YUI,5Y2S,5Y2R,5WEX,5VGY,5UMC,5ULN,5U0G,5U0F,5U0E,5U0D,5TYA,5TY9,5TY8,5TY1,5TXY,5THN,5THJ,5TFX,5O07,5NEE,5NEA,5N25,5N24,5N1S,5N1R,5N0E,5N0D,5M78,5LMD,5LLH,5LLG,5LLE,5LLC,5LL8,5LL4,5L9E,5L70,5L6T,5L6K,5L3O,5JQT,5JQ0,5J8Z,5GMN,5FNM,5FNL,5FNK,5FNJ,5FNI,5FNH,5FNG,5FLT,5FLS,5FLR,5FLQ,5FLP,5FLO,5FDI,5FDC,5EHW,5EHV,5EHE,5EH8,5EH7,5EH5,5E2R,5DSR,5DSQ,5DSP,5DSO,5DSM,5DSL,5DSK,5DRS,5DOH,5DOG,5C8I,5BYI,5A6H,4YYT,4YXU,4YXO,4YXI,4YX4,4XE1,4WW6,4WL4,4RUZ,4RUY,4RUX,4RN4,4RH2,4RFD,4RFC,4R5B,4QTL,4QSI,4QSB,4QSA,4QJM,4QIY,4Q9Y,4Q99,4Q90,4Q8Z,4Q8Y,4Q8X,4Q87,4Q83,4Q81,4Q7W,4Q7V,4Q7S,4Q7P,4Q6E,4Q6D,4Q49,4PZH,4PYY,4PYX,4PQ7,4N16,4N0X,4MTY,4MO8,4MLX,4MLT,4LP6,4LHI,4KNJ,4KNI,4ITO,4HT0 Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131507 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)cc2F)c2nc(C3CC3)nn2c1=O InChI=1S/C19H22FN5O2S/c1-11(2)15-10-24(9-13-6-7-14(8-16(13)20)28(3,21)27)19-22-17(12-4-5-12)23-25(19)18(15)26/h6-8,10-12,21H,4-5,9H2,1-3H3 OCEOZIJOINYLON-UHFFFAOYSA-N 114431 US20260001886, Compound 69 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114431 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114431&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 2205361 252663936 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131508 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2F)c2cc(C3CC3)nn2c1=O InChI=1S/C20H23FN4O2S/c1-12(2)16-11-24(10-14-6-7-15(8-17(14)21)28(3,22)27)19-9-18(13-4-5-13)23-25(19)20(16)26/h6-9,11-13,22H,4-5,10H2,1-3H3 YKFLTJHOKHSEBF-UHFFFAOYSA-N 114432 US20260001886, Compound 70 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114432 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114432&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 16406841 242053897 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131509 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(C)(=N)=O InChI=1S/C20H25N5O2S/c1-12(2)16-11-24(10-14-5-8-17(13(3)9-14)28(4,21)27)20-22-18(15-6-7-15)23-25(20)19(16)26/h5,8-9,11-12,15,21H,6-7,10H2,1-4H3 CQUIZMIQAFFVDT-UHFFFAOYSA-N 114433 US20260001886, Compound 71 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114433 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114433&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 7693217 252663937 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131510 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(C)(=N)=O InChI=1S/C20H25N5O2S/c1-12(2)16-11-24(10-14-5-8-17(13(3)9-14)28(4,21)27)20-22-18(15-6-7-15)23-25(20)19(16)26/h5,8-9,11-12,15,21H,6-7,10H2,1-4H3 CQUIZMIQAFFVDT-UHFFFAOYSA-N 114433 US20260001886, Compound 71 Carbonic anhydrase 2 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114433 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114433&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 7693217 252663937 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131511 Cc1cc(Cn2cc(C(C)C)c(=O)n3nc(C4CC4)nc23)ccc1S(C)(=N)=O InChI=1S/C20H25N5O2S/c1-12(2)16-11-24(10-14-5-8-17(13(3)9-14)28(4,21)27)20-22-18(15-6-7-15)23-25(20)19(16)26/h5,8-9,11-12,15,21H,6-7,10H2,1-4H3 CQUIZMIQAFFVDT-UHFFFAOYSA-N 114433 US20260001886, Compound 71 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114433 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114433&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 7693217 252663937 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131512 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)c(F)c2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H23FN4O2S/c1-12(2)15-11-24(10-13-4-7-18(16(21)8-13)28(3,22)27)19-9-17(14-5-6-14)23-25(19)20(15)26/h4,7-9,11-12,14,22H,5-6,10H2,1-3H3 ZIIIGVSMTOWLPM-UHFFFAOYSA-N 114434 US20260001886, Compound 72 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.51 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114434&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 24818595 252663938 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131513 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)c(F)c2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H23FN4O2S/c1-12(2)15-11-24(10-13-4-7-18(16(21)8-13)28(3,22)27)19-9-17(14-5-6-14)23-25(19)20(15)26/h4,7-9,11-12,14,22H,5-6,10H2,1-3H3 ZIIIGVSMTOWLPM-UHFFFAOYSA-N 114434 US20260001886, Compound 72 Carbonic anhydrase 2 Homo sapiens 501187 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1193&target=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114434&enzyme=Carbonic+anhydrase+2&column=ki&startPg=0&Increment=50&submit=Search 24818595 252663938 1 MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK 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Carbonic anhydrase 2 CAH2_HUMAN P00918 B2R7G8 Q6FI12 Q96ET9 131514 CC(C)c1cn(Cc2ccc([S@](C)(=N)=O)c(F)c2)c2cc(C3CC3)nn2c1=O InChI=1S/C20H23FN4O2S/c1-12(2)15-11-24(10-13-4-7-18(16(21)8-13)28(3,22)27)19-9-17(14-5-6-14)23-25(19)20(15)26/h4,7-9,11-12,14,22H,5-6,10H2,1-3H3 ZIIIGVSMTOWLPM-UHFFFAOYSA-N 114434 US20260001886, Compound 72 Carbonic anhydrase 1 Homo sapiens >100000000 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114434 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=1192&target=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114434&enzyme=Carbonic+anhydrase+1&column=ki&startPg=0&Increment=50&submit=Search 24818595 252663938 1 MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF 9H81,9EP2,8RLO,8QUN,8QQ9,8QGV,8Q7G,8Q6L,8CDZ,8CDX,7ZL5,7QOB,7Q0D,7PLF,6Y00,6XZY,6XZX,6XZS,6XZO,6XZE,6SWM,6I0L,6I0J,6HWZ,6G3V,6FAG,6FAF,6F3B,6EX1,6EVR,5GMM,3W6I,3W6H,3LXE,2NN7,2NN1,2NMX,2FW4,2FOY,1HUH,1HUG,1HCB,1CZM,1BZM,1AZM,9HWN,8S4F,5E2M,4WUQ,4WUP,4WR7,2IT4 Carbonic anhydrase 1 CAH1_HUMAN P00915 131515 CC(C)c1cn(Cc2ccc(S(C)(=N)=O)cc2F)c2c(F)c(C3CC3)nn2c1=O InChI=1S/C20H22F2N4O2S/c1-11(2)15-10-25(9-13-6-7-14(8-16(13)21)29(3,23)28)19-17(22)18(12-4-5-12)24-26(19)20(15)27/h6-8,10-12,23H,4-5,9H2,1-3H3 TUDWASLPWBQFRM-UHFFFAOYSA-N 114435 US20260001886, Compound 73 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 2.51 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114435 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114435&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 16438048 252663939 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3 131516 CC(C)c1cn(Cc2ccc([S@@](C)(=N)=O)cc2F)c2c(F)c(C3CC3)nn2c1=O InChI=1S/C20H22F2N4O2S/c1-11(2)15-10-25(9-13-6-7-14(8-16(13)21)29(3,23)28)19-17(22)18(12-4-5-12)24-26(19)20(15)27/h6-8,10-12,23H,4-5,9H2,1-3H3 TUDWASLPWBQFRM-UHFFFAOYSA-N 114436 US20260001886, Compound 73A Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Homo sapiens 3.16 US Patent 10.7270/Q21G0S25 US20260001886 Bell, AS; Culurgioni, S; Barbeau, OR; Chemi, G; Sebastian-Perez, V 1/1/2026 5/13/2026 RE Ventures I http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114436 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=50004119&target=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114436&enzyme=Ectonucleotide+pyrophosphatase%2Fphosphodiesterase+family+member+1&column=ki&startPg=0&Increment=50&submit=Search 2959558 252663940 1 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED 6WFJ,6WEW,6WEV,6WEU,6WET Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1_HUMAN P22413 Q5T9R6 Q9NPZ3 Q9P1P6 Q9UP61 Q9Y6K3