BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 131517 Cc1cc2cnc(N[C@@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3F)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H28F2N6O2S/c1-12-8-13-9-24-20(26-19(13)28(12)18-4-6-23-10-15(18)21)25-17-5-7-27(11-16(17)22)31(29,30)14-2-3-14/h8-9,14-18,23H,2-7,10-11H2,1H3,(H,24,25,26) MXNILZSACYSDLE-UHFFFAOYSA-N 114450 US20260001887, Example 5 Cyclin-dependent kinase 1 Homo sapiens 4226 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114450 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114450&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 91899723 252663954 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131518 Cc1cc2cnc(N[C@@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3F)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H28F2N6O2S/c1-12-8-13-9-24-20(26-19(13)28(12)18-4-6-23-10-15(18)21)25-17-5-7-27(11-16(17)22)31(29,30)14-2-3-14/h8-9,14-18,23H,2-7,10-11H2,1H3,(H,24,25,26) MXNILZSACYSDLE-UHFFFAOYSA-N 114450 US20260001887, Example 5 Cyclin-dependent kinase 4 Homo sapiens 26.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114450 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114450&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 91899723 252663954 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131519 O=S(=O)(C1CC1)N1CC[C@@H](Nc2ncc3ccn([C@@H]4CCNC[C@@H]4F)c3n2)[C@H](F)C1 InChI=1S/C19H26F2N6O2S/c20-14-10-22-6-3-17(14)27-8-4-12-9-23-19(25-18(12)27)24-16-5-7-26(11-15(16)21)30(28,29)13-1-2-13/h4,8-9,13-17,22H,1-3,5-7,10-11H2,(H,23,24,25) YHAPYWMTTWTEHX-UHFFFAOYSA-N 114452 US20260001887, Example 36 Cyclin-dependent kinase 1 Homo sapiens 3099 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114452&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51359977 252663956 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131520 O=S(=O)(C1CC1)N1CC[C@@H](Nc2ncc3ccn([C@@H]4CCNC[C@@H]4F)c3n2)[C@H](F)C1 InChI=1S/C19H26F2N6O2S/c20-14-10-22-6-3-17(14)27-8-4-12-9-23-19(25-18(12)27)24-16-5-7-26(11-15(16)21)30(28,29)13-1-2-13/h4,8-9,13-17,22H,1-3,5-7,10-11H2,(H,23,24,25) YHAPYWMTTWTEHX-UHFFFAOYSA-N 114452 US20260001887, Example 36 Cyclin-dependent kinase 4 Homo sapiens 22.5 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114452 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114452&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51359977 252663956 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131521 Cc1cc2cnc(NC3CCN(S(=O)(=O)C4CC4)CC3)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H29FN6O2S/c1-13-10-14-11-23-20(25-19(14)27(13)18-4-7-22-12-17(18)21)24-15-5-8-26(9-6-15)30(28,29)16-2-3-16/h10-11,15-18,22H,2-9,12H2,1H3,(H,23,24,25) OQHHHSCSBXEBLK-UHFFFAOYSA-N 114453 US20260001887, Example 5a Cyclin-dependent kinase 1 Homo sapiens 2565 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114453&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51360010 252663957 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131522 Cc1cc2cnc(NC3CCN(S(=O)(=O)C4CC4)CC3)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H29FN6O2S/c1-13-10-14-11-23-20(25-19(14)27(13)18-4-7-22-12-17(18)21)24-15-5-8-26(9-6-15)30(28,29)16-2-3-16/h10-11,15-18,22H,2-9,12H2,1H3,(H,23,24,25) OQHHHSCSBXEBLK-UHFFFAOYSA-N 114453 US20260001887, Example 5a Cyclin-dependent kinase 4 Homo sapiens 74.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114453 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114453&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51360010 252663957 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131523 Cc1cc2cnc(N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3F)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H28F2N6O2S/c1-12-8-13-9-24-20(26-19(13)28(12)18-4-6-23-10-15(18)21)25-17-5-7-27(11-16(17)22)31(29,30)14-2-3-14/h8-9,14-18,23H,2-7,10-11H2,1H3,(H,24,25,26) MXNILZSACYSDLE-UHFFFAOYSA-N 114454 US20260001887, Example 5b Cyclin-dependent kinase 1 Homo sapiens 4349 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114454 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114454&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51360068 252663958 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131524 Cc1cc2cnc(N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3F)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H28F2N6O2S/c1-12-8-13-9-24-20(26-19(13)28(12)18-4-6-23-10-15(18)21)25-17-5-7-27(11-16(17)22)31(29,30)14-2-3-14/h8-9,14-18,23H,2-7,10-11H2,1H3,(H,24,25,26) MXNILZSACYSDLE-UHFFFAOYSA-N 114454 US20260001887, Example 5b Cyclin-dependent kinase 4 Homo sapiens 100.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114454 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114454&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51360068 252663958 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131525 Cc1cc2cnc(N[C@@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3F)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H28F2N6O2S/c1-12-8-13-9-24-20(26-19(13)28(12)18-4-6-23-10-15(18)21)25-17-5-7-27(11-16(17)22)31(29,30)14-2-3-14/h8-9,14-18,23H,2-7,10-11H2,1H3,(H,24,25,26) MXNILZSACYSDLE-UHFFFAOYSA-N 114455 US20260001887, Example 5c Cyclin-dependent kinase 1 Homo sapiens 3490 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114455 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114455&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51360071 252663959 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131526 Cc1cc2cnc(N[C@@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3F)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H28F2N6O2S/c1-12-8-13-9-24-20(26-19(13)28(12)18-4-6-23-10-15(18)21)25-17-5-7-27(11-16(17)22)31(29,30)14-2-3-14/h8-9,14-18,23H,2-7,10-11H2,1H3,(H,24,25,26) MXNILZSACYSDLE-UHFFFAOYSA-N 114455 US20260001887, Example 5c Cyclin-dependent kinase 4 Homo sapiens 120 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114455 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114455&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51360071 252663959 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131527 Cc1cc2cnc(N[C@@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3F)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H28F2N6O2S/c1-12-8-13-9-24-20(26-19(13)28(12)18-4-6-23-10-15(18)21)25-17-5-7-27(11-16(17)22)31(29,30)14-2-3-14/h8-9,14-18,23H,2-7,10-11H2,1H3,(H,24,25,26) MXNILZSACYSDLE-UHFFFAOYSA-N 114456 US20260001887, Example 5d Cyclin-dependent kinase 1 Homo sapiens >10000 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114456&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51360082 252663960 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131528 Cc1cc2cnc(N[C@@H]3CCN(S(=O)(=O)C4CC4)C[C@H]3F)nc2n1[C@@H]1CCNC[C@@H]1F InChI=1S/C20H28F2N6O2S/c1-12-8-13-9-24-20(26-19(13)28(12)18-4-6-23-10-15(18)21)25-17-5-7-27(11-16(17)22)31(29,30)14-2-3-14/h8-9,14-18,23H,2-7,10-11H2,1H3,(H,24,25,26) MXNILZSACYSDLE-UHFFFAOYSA-N 114456 US20260001887, Example 5d Cyclin-dependent kinase 4 Homo sapiens 267 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114456 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114456&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51360082 252663960 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131529 O=S(=O)(C1CC1)N1CCC(Nc2ncc3ccn([C@@H]4CCNC[C@@H]4F)c3n2)CC1 InChI=1S/C19H27FN6O2S/c20-16-12-21-7-3-17(16)26-10-4-13-11-22-19(24-18(13)26)23-14-5-8-25(9-6-14)29(27,28)15-1-2-15/h4,10-11,14-17,21H,1-3,5-9,12H2,(H,22,23,24) ZMMLMHMXDGUQTL-UHFFFAOYSA-N 114457 US20260001887, Example 36a Cyclin-dependent kinase 1 Homo sapiens 2052 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114457 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114457&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51361243 252663961 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131530 O=S(=O)(C1CC1)N1CCC(Nc2ncc3ccn([C@@H]4CCNC[C@@H]4F)c3n2)CC1 InChI=1S/C19H27FN6O2S/c20-16-12-21-7-3-17(16)26-10-4-13-11-22-19(24-18(13)26)23-14-5-8-25(9-6-14)29(27,28)15-1-2-15/h4,10-11,14-17,21H,1-3,5-9,12H2,(H,22,23,24) ZMMLMHMXDGUQTL-UHFFFAOYSA-N 114457 US20260001887, Example 36a Cyclin-dependent kinase 4 Homo sapiens 80.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114457 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114457&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51361243 252663961 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131531 O=S(=O)(C1CC1)N1CC[C@H](Nc2ncc3ccn([C@@H]4CCNC[C@@H]4F)c3n2)[C@H](F)C1 InChI=1S/C19H26F2N6O2S/c20-14-10-22-6-3-17(14)27-8-4-12-9-23-19(25-18(12)27)24-16-5-7-26(11-15(16)21)30(28,29)13-1-2-13/h4,8-9,13-17,22H,1-3,5-7,10-11H2,(H,23,24,25) YHAPYWMTTWTEHX-UHFFFAOYSA-N 114458 US20260001887, Example 36b Cyclin-dependent kinase 1 Homo sapiens 1274 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114458 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114458&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51361244 252663962 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131532 O=S(=O)(C1CC1)N1CC[C@H](Nc2ncc3ccn([C@@H]4CCNC[C@@H]4F)c3n2)[C@H](F)C1 InChI=1S/C19H26F2N6O2S/c20-14-10-22-6-3-17(14)27-8-4-12-9-23-19(25-18(12)27)24-16-5-7-26(11-15(16)21)30(28,29)13-1-2-13/h4,8-9,13-17,22H,1-3,5-7,10-11H2,(H,23,24,25) YHAPYWMTTWTEHX-UHFFFAOYSA-N 114458 US20260001887, Example 36b Cyclin-dependent kinase 4 Homo sapiens 55.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114458 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114458&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51361244 252663962 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131533 O=S(=O)(C1CC1)N1CC[C@@H](Nc2ncc3ccn([C@@H]4CCNC[C@@H]4F)c3n2)[C@H](F)C1 InChI=1S/C19H26F2N6O2S/c20-14-10-22-6-3-17(14)27-8-4-12-9-23-19(25-18(12)27)24-16-5-7-26(11-15(16)21)30(28,29)13-1-2-13/h4,8-9,13-17,22H,1-3,5-7,10-11H2,(H,23,24,25) YHAPYWMTTWTEHX-UHFFFAOYSA-N 114459 US20260001887, Example 36d Cyclin-dependent kinase 1 Homo sapiens >10000 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114459&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51361306 252663963 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131534 O=S(=O)(C1CC1)N1CC[C@@H](Nc2ncc3ccn([C@@H]4CCNC[C@@H]4F)c3n2)[C@H](F)C1 InChI=1S/C19H26F2N6O2S/c20-14-10-22-6-3-17(14)27-8-4-12-9-23-19(25-18(12)27)24-16-5-7-26(11-15(16)21)30(28,29)13-1-2-13/h4,8-9,13-17,22H,1-3,5-7,10-11H2,(H,23,24,25) YHAPYWMTTWTEHX-UHFFFAOYSA-N 114459 US20260001887, Example 36d Cyclin-dependent kinase 4 Homo sapiens 61.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114459 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114459&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51361306 252663963 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131535 CN(C)C(=O)c1cc2cnc(N[C@@H]3CCN(S(C)(=O)=O)C[C@H]3O)nc2n1C1CCCC1 InChI=1S/C20H30N6O4S/c1-24(2)19(28)16-10-13-11-21-20(23-18(13)26(16)14-6-4-5-7-14)22-15-8-9-25(12-17(15)27)31(3,29)30/h10-11,14-15,17,27H,4-9,12H2,1-3H3,(H,21,22,23) QRYUAHIOTKADCJ-UHFFFAOYSA-N 114460 US20260001887, Compound B (Tuojie biotech, CN114790206) Cyclin-dependent kinase 1 Homo sapiens 5701 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114460&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 51049789 252663964 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131536 CN(C)C(=O)c1cc2cnc(N[C@@H]3CCN(S(C)(=O)=O)C[C@H]3O)nc2n1C1CCCC1 InChI=1S/C20H30N6O4S/c1-24(2)19(28)16-10-13-11-21-20(23-18(13)26(16)14-6-4-5-7-14)22-15-8-9-25(12-17(15)27)31(3,29)30/h10-11,14-15,17,27H,4-9,12H2,1-3H3,(H,21,22,23) QRYUAHIOTKADCJ-UHFFFAOYSA-N 114460 US20260001887, Compound B (Tuojie biotech, CN114790206) Cyclin-dependent kinase 4 Homo sapiens 6.60 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114460 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114460&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 51049789 252663964 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131537 CNC(=O)Cc1cc2cnc(N[C@@H]3CCN(S(C)(=O)=O)C[C@H]3O)nc2n1C1CCCC1 InChI=1S/C20H30N6O4S/c1-21-18(28)10-15-9-13-11-22-20(24-19(13)26(15)14-5-3-4-6-14)23-16-7-8-25(12-17(16)27)31(2,29)30/h9,11,14,16-17,27H,3-8,10,12H2,1-2H3,(H,21,28)(H,22,23,24) UGFBYFRPECIZKB-UHFFFAOYSA-N 114461 US20260001887, Compound B-1 (Tuojie Biotech, CN114790206) Cyclin-dependent kinase 1 Homo sapiens >10000 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114461&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 60157876 252663965 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131538 CNC(=O)Cc1cc2cnc(N[C@@H]3CCN(S(C)(=O)=O)C[C@H]3O)nc2n1C1CCCC1 InChI=1S/C20H30N6O4S/c1-21-18(28)10-15-9-13-11-22-20(24-19(13)26(15)14-5-3-4-6-14)23-16-7-8-25(12-17(16)27)31(2,29)30/h9,11,14,16-17,27H,3-8,10,12H2,1-2H3,(H,21,28)(H,22,23,24) UGFBYFRPECIZKB-UHFFFAOYSA-N 114461 US20260001887, Compound B-1 (Tuojie Biotech, CN114790206) Cyclin-dependent kinase 4 Homo sapiens 296 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114461 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114461&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 60157876 252663965 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131539 CN(C)C(=O)c1cc2cnc(N[C@@H]3CCN(S(C)(=O)=O)C[C@H]3O)cc2n1C1CCCC1 InChI=1S/C21H31N5O4S/c1-24(2)21(28)18-10-14-12-22-20(11-17(14)26(18)15-6-4-5-7-15)23-16-8-9-25(13-19(16)27)31(3,29)30/h10-12,15-16,19,27H,4-9,13H2,1-3H3,(H,22,23) VSAWODONWXLGNU-UHFFFAOYSA-N 114462 US20260001887, Compound B-2 (Tuojie biotech, CN114790206) Cyclin-dependent kinase 1 Homo sapiens >10000 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114462&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 60159077 252663966 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131540 CN(C)C(=O)c1cc2cnc(N[C@@H]3CCN(S(C)(=O)=O)C[C@H]3O)cc2n1C1CCCC1 InChI=1S/C21H31N5O4S/c1-24(2)21(28)18-10-14-12-22-20(11-17(14)26(18)15-6-4-5-7-15)23-16-8-9-25(13-19(16)27)31(3,29)30/h10-12,15-16,19,27H,4-9,13H2,1-3H3,(H,22,23) VSAWODONWXLGNU-UHFFFAOYSA-N 114462 US20260001887, Compound B-2 (Tuojie biotech, CN114790206) Cyclin-dependent kinase 4 Homo sapiens 8.70 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114462 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114462&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 60159077 252663966 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131541 CC(=O)Nc1cc2cnc(N[C@@H]3CCN(S(C)(=O)=O)C[C@H]3O)nc2n1C1CCCC1 InChI=1S/C19H28N6O4S/c1-12(26)21-17-9-13-10-20-19(23-18(13)25(17)14-5-3-4-6-14)22-15-7-8-24(11-16(15)27)30(2,28)29/h9-10,14-16,27H,3-8,11H2,1-2H3,(H,21,26)(H,20,22,23) XBEHEVLFIGHMEE-UHFFFAOYSA-N 114463 US20260001887, Compound B-3 (Tuojie biotech, CN114790206) Cyclin-dependent kinase 1 Homo sapiens >10000 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114463&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 70680043 252663967 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131542 CC(=O)Nc1cc2cnc(N[C@@H]3CCN(S(C)(=O)=O)C[C@H]3O)nc2n1C1CCCC1 InChI=1S/C19H28N6O4S/c1-12(26)21-17-9-13-10-20-19(23-18(13)25(17)14-5-3-4-6-14)22-15-7-8-24(11-16(15)27)30(2,28)29/h9-10,14-16,27H,3-8,11H2,1-2H3,(H,21,26)(H,20,22,23) XBEHEVLFIGHMEE-UHFFFAOYSA-N 114463 US20260001887, Compound B-3 (Tuojie biotech, CN114790206) Cyclin-dependent kinase 4 Homo sapiens 226 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114463 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114463&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 70680043 252663967 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131543 C[C@]1(CCC[C@H]1N2c3c(cnc(n3)NC4CCN(CC4)S(=O)(=O)C)C=C(C2=O)C(F)F)O InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25) QIEKHLDZKRQLLN-UHFFFAOYSA-N 370121 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one::US10233188, Example 10::US10800783, Example 10::US11396512, Example 10::US20260001887, Compound C Pfizer, F-06873600 Cyclin-dependent kinase 1 Homo sapiens 46.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370121&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search WG1 7KJS 134247638 402357205 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131544 C[C@]1(CCC[C@H]1N2c3c(cnc(n3)NC4CCN(CC4)S(=O)(=O)C)C=C(C2=O)C(F)F)O InChI=1S/C20H27F2N5O4S/c1-20(29)7-3-4-15(20)27-17-12(10-14(16(21)22)18(27)28)11-23-19(25-17)24-13-5-8-26(9-6-13)32(2,30)31/h10-11,13,15-16,29H,3-9H2,1-2H3,(H,23,24,25) QIEKHLDZKRQLLN-UHFFFAOYSA-N 370121 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(methylsulfonyl)piperidin-4-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one::US10233188, Example 10::US10800783, Example 10::US11396512, Example 10::US20260001887, Compound C Pfizer, F-06873600 Cyclin-dependent kinase 4 Homo sapiens 7.00 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=370121 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=370121&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search WG1 7KJS 134247638 402357205 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131545 CN(C)C(=O)c1cc2cnc(NC3CCN(S(C)(=O)=O)CC3)nc2n1C12CC(C1)C2 InChI=1S/C20H28N6O3S/c1-24(2)18(27)16-8-14-12-21-19(22-15-4-6-25(7-5-15)30(3,28)29)23-17(14)26(16)20-9-13(10-20)11-20/h8,12-13,15H,4-7,9-11H2,1-3H3,(H,21,22,23) QIJADTSTMGBTNX-UHFFFAOYSA-N 114716 US20260001887, Compound D SPV Therapeutics, WO2020/140052 Cyclin-dependent kinase 1 Homo sapiens 230 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114716&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 2109648 252664197 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131546 CN(C)C(=O)c1cc2cnc(NC3CCN(S(C)(=O)=O)CC3)nc2n1C12CC(C1)C2 InChI=1S/C20H28N6O3S/c1-24(2)18(27)16-8-14-12-21-19(22-15-4-6-25(7-5-15)30(3,28)29)23-17(14)26(16)20-9-13(10-20)11-20/h8,12-13,15H,4-7,9-11H2,1-3H3,(H,21,22,23) QIJADTSTMGBTNX-UHFFFAOYSA-N 114716 US20260001887, Compound D SPV Therapeutics, WO2020/140052 Cyclin-dependent kinase 4 Homo sapiens 16.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114716 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114716&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 2109648 252664197 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131547 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C(=O)N3CC4CCC(C3)N4)nc2n1C1CCN(CC1)C1CC1 |TLB:18:20:27:23.24| InChI=1S/C29H37N9O2/c1-35(2)28(40)24-13-19-15-31-29(34-26(19)38(24)23-9-11-36(12-10-23)22-6-7-22)33-25-8-3-18(14-30-25)27(39)37-16-20-4-5-21(17-37)32-20/h3,8,13-15,20-23,32H,4-7,9-12,16-17H2,1-2H3,(H,30,31,33,34) OPRDAHHLGNDNTD-UHFFFAOYSA-N 147017 US8957074, 56::US20260001887, Compound E Novartis, WO2011/10409 Cyclin-dependent kinase 1 Homo sapiens >10000 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=147017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=147017&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 67354334 252107948 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131548 CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C(=O)N3CC4CCC(C3)N4)nc2n1C1CCN(CC1)C1CC1 |TLB:18:20:27:23.24| InChI=1S/C29H37N9O2/c1-35(2)28(40)24-13-19-15-31-29(34-26(19)38(24)23-9-11-36(12-10-23)22-6-7-22)33-25-8-3-18(14-30-25)27(39)37-16-20-4-5-21(17-37)32-20/h3,8,13-15,20-23,32H,4-7,9-12,16-17H2,1-2H3,(H,30,31,33,34) OPRDAHHLGNDNTD-UHFFFAOYSA-N 147017 US8957074, 56::US20260001887, Compound E Novartis, WO2011/10409 Cyclin-dependent kinase 4 Homo sapiens 200 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=147017 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=147017&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 67354334 252107948 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131549 CS(=O)(=O)N1CCC(Nc2ncc3ccc(C4CCCC4)n3n2)CC1 InChI=1S/C17H25N5O2S/c1-25(23,24)21-10-8-14(9-11-21)19-17-18-12-15-6-7-16(22(15)20-17)13-4-2-3-5-13/h6-7,12-14H,2-5,8-11H2,1H3,(H,19,20) LSCBPZCBHUIKQP-UHFFFAOYSA-N 742517 7-cyclopentyl-N-(1- (methylsulfonyl)piperidin-4- yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine::US20250163063, Example 31::US20260001887, Compound F Example 31 Kinnate WO2023/147372 Cyclin-dependent kinase 1 Homo sapiens 360 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=742517 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=742517&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169117107 518815256 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131550 CS(=O)(=O)N1CCC(Nc2ncc3ccc(C4CCCC4)n3n2)CC1 InChI=1S/C17H25N5O2S/c1-25(23,24)21-10-8-14(9-11-21)19-17-18-12-15-6-7-16(22(15)20-17)13-4-2-3-5-13/h6-7,12-14H,2-5,8-11H2,1H3,(H,19,20) LSCBPZCBHUIKQP-UHFFFAOYSA-N 742517 7-cyclopentyl-N-(1- (methylsulfonyl)piperidin-4- yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine::US20250163063, Example 31::US20260001887, Compound F Example 31 Kinnate WO2023/147372 Cyclin-dependent kinase 4 Homo sapiens 33.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=742517 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=742517&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 169117107 518815256 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131551 CS(=O)(=O)N1CC[C@@H](Nc2ncc3ccc(C4CCCC4)n3n2)[C@H](F)C1 InChI=1S/C17H24FN5O2S/c1-26(24,25)22-9-8-15(14(18)11-22)20-17-19-10-13-6-7-16(23(13)21-17)12-4-2-3-5-12/h6-7,10,12,14-15H,2-5,8-9,11H2,1H3,(H,20,21) NFMISPQTJLTOMX-UHFFFAOYSA-N 742783 7-cyclopentyl-N-((3R,4R)-3-fluoro-1- (methylsulfonyl)piperidin-4- yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine::US20250163063, Example 306::US20260001887, Compound G Example 306 Kinnate WO2023/147372 Cyclin-dependent kinase 1 Homo sapiens 900 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=742783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=742783&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 169118025 518815522 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131552 CS(=O)(=O)N1CC[C@@H](Nc2ncc3ccc(C4CCCC4)n3n2)[C@H](F)C1 InChI=1S/C17H24FN5O2S/c1-26(24,25)22-9-8-15(14(18)11-22)20-17-19-10-13-6-7-16(23(13)21-17)12-4-2-3-5-12/h6-7,10,12,14-15H,2-5,8-9,11H2,1H3,(H,20,21) NFMISPQTJLTOMX-UHFFFAOYSA-N 742783 7-cyclopentyl-N-((3R,4R)-3-fluoro-1- (methylsulfonyl)piperidin-4- yl)pyrrolo[2,1-f][1,2,4]triazin-2-amine::US20250163063, Example 306::US20260001887, Compound G Example 306 Kinnate WO2023/147372 Cyclin-dependent kinase 4 Homo sapiens 8.20 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=742783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=742783&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 169118025 518815522 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131553 O[C@@H]1COCC[C@H]1Nc1ncc2c(F)c(Cl)c(C3CCN(CC(F)(F)F)CC3)n2n1 InChI=1S/C18H22ClF4N5O2/c19-14-15(20)12-7-24-17(25-11-3-6-30-8-13(11)29)26-28(12)16(14)10-1-4-27(5-2-10)9-18(21,22)23/h7,10-11,13,29H,1-6,8-9H2,(H,25,26) WWWADLBVGBSZRM-UHFFFAOYSA-N 742859 (3S,4R)-4-((6-chloro-5-fluoro-7-(1- (2,2,2-trifluoroethyl)piperidin-4- yl)pyrrolo[2,1-f][1,2,4]triazin-2- yl)amino)tetrahydro-2H-pyran-3-ol::US20250163063, Example 382::US20260001887, Compound H Example 382 Kinnate WO2023/147372 Cyclin-dependent kinase 1 Homo sapiens 9360 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=742859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=742859&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 170063208 518815598 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131554 O[C@@H]1COCC[C@H]1Nc1ncc2c(F)c(Cl)c(C3CCN(CC(F)(F)F)CC3)n2n1 InChI=1S/C18H22ClF4N5O2/c19-14-15(20)12-7-24-17(25-11-3-6-30-8-13(11)29)26-28(12)16(14)10-1-4-27(5-2-10)9-18(21,22)23/h7,10-11,13,29H,1-6,8-9H2,(H,25,26) WWWADLBVGBSZRM-UHFFFAOYSA-N 742859 (3S,4R)-4-((6-chloro-5-fluoro-7-(1- (2,2,2-trifluoroethyl)piperidin-4- yl)pyrrolo[2,1-f][1,2,4]triazin-2- yl)amino)tetrahydro-2H-pyran-3-ol::US20250163063, Example 382::US20260001887, Compound H Example 382 Kinnate WO2023/147372 Cyclin-dependent kinase 4 Homo sapiens 8.10 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=742859 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=742859&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 170063208 518815598 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61 131555 CN(C)C(=O)c1cc2cnc(nc2n1C3CCCC3)Nc4ccc(cn4)N5CCNCC5 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 US8962630, 74::Ribociclib::LEE011::Kisqali::7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::US10570141, Comparative Example 1::US20260001887, Example Ribociclib Cyclin-dependent kinase 1 Homo sapiens >10000 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=804&target=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-dependent+kinase+1&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T,9BLH 44631912 252148259 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 7NJ0,9SKQ,4YC6,6GU7,6GU6,6GU4,6GU3,6GU2,5LQF,5HQ0,4YC3,4Y72 Cyclin-dependent kinase 1 CDK1_HUMAN P06493 A8K7C4 C9J497 O60764 131556 CN(C)C(=O)c1cc2cnc(nc2n1C3CCCC3)Nc4ccc(cn4)N5CCNCC5 InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28) RHXHGRAEPCAFML-UHFFFAOYSA-N 148264 US8962630, 74::Ribociclib::LEE011::Kisqali::7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide::US10570141, Comparative Example 1::US20260001887, Example Ribociclib Cyclin-dependent kinase 4 Homo sapiens 14.0 US Patent 10.7270/Q2WQ08M9 US20260001887 BRINER, K; CHEN, X; GAO, X; JOSEPH, S; PFISTER, KB; RAUNIYAR, V; SMITH, TD; YUAN, J; WU, X; ZECRI, FJ 1/1/2026 5/13/2026 Novartis http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=148264 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=799&target=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=148264&enzyme=Cyclin-dependent+kinase+4&column=ki&startPg=0&Increment=50&submit=Search 6ZZ 5L2T,9BLH 44631912 252148259 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 5FWP,5FWM,5FWL,5FWK,3G33,7SJ3 Cyclin-dependent kinase 4 CDK4_HUMAN P11802 B2R9A0 B4DNF9 O00576 Q6FG61