BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Date of publication Date in BindingDB Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence 1 PDB ID(s) of Target Chain 1 UniProt (SwissProt) Recommended Name of Target Chain 1 UniProt (SwissProt) Entry Name of Target Chain 1 UniProt (SwissProt) Primary ID of Target Chain 1 UniProt (SwissProt) Secondary ID(s) of Target Chain 1 UniProt (SwissProt) Alternative ID(s) of Target Chain 1 UniProt (TrEMBL) Submitted Name of Target Chain 1 UniProt (TrEMBL) Entry Name of Target Chain 1 UniProt (TrEMBL) Primary ID of Target Chain 1 UniProt (TrEMBL) Secondary ID(s) of Target Chain 1 UniProt (TrEMBL) Alternative ID(s) of Target Chain 1 BindingDB Target Chain Sequence 2 PDB ID(s) of Target Chain 2 UniProt (SwissProt) Recommended Name of Target Chain 2 UniProt (SwissProt) Entry Name of Target Chain 2 UniProt (SwissProt) Primary ID of Target Chain 2 UniProt (SwissProt) Secondary ID(s) of Target Chain 2 UniProt (SwissProt) Alternative ID(s) of Target Chain 2 UniProt (TrEMBL) Submitted Name of Target Chain 2 UniProt (TrEMBL) Entry Name of Target Chain 2 UniProt (TrEMBL) Primary ID of Target Chain 2 UniProt (TrEMBL) Secondary ID(s) of Target Chain 2 UniProt (TrEMBL) Alternative ID(s) of Target Chain 2 BindingDB Target Chain Sequence 3 PDB ID(s) of Target Chain 3 UniProt (SwissProt) Recommended Name of Target Chain 3 UniProt (SwissProt) Entry Name of Target Chain 3 UniProt (SwissProt) Primary ID of Target Chain 3 UniProt (SwissProt) Secondary ID(s) of Target Chain 3 UniProt (SwissProt) Alternative ID(s) of Target Chain 3 UniProt (TrEMBL) Submitted Name of Target Chain 3 UniProt (TrEMBL) Entry Name of Target Chain 3 UniProt (TrEMBL) Primary ID of Target Chain 3 UniProt (TrEMBL) Secondary ID(s) of Target Chain 3 UniProt (TrEMBL) Alternative ID(s) of Target Chain 3 BindingDB Target Chain Sequence 4 PDB ID(s) of Target Chain 4 UniProt (SwissProt) Recommended Name of Target Chain 4 UniProt (SwissProt) Entry Name of Target Chain 4 UniProt (SwissProt) Primary ID of Target Chain 4 UniProt (SwissProt) Secondary ID(s) of Target Chain 4 UniProt (SwissProt) Alternative ID(s) of Target Chain 4 UniProt (TrEMBL) Submitted Name of Target Chain 4 UniProt (TrEMBL) Entry Name of Target Chain 4 UniProt (TrEMBL) Primary ID of Target Chain 4 UniProt (TrEMBL) Secondary ID(s) of Target Chain 4 UniProt (TrEMBL) Alternative ID(s) of Target Chain 4 BindingDB Target Chain Sequence 5 PDB ID(s) of Target Chain 5 UniProt (SwissProt) Recommended Name of Target Chain 5 UniProt (SwissProt) Entry Name of Target Chain 5 UniProt (SwissProt) Primary ID of Target Chain 5 UniProt (SwissProt) Secondary ID(s) of Target Chain 5 UniProt (SwissProt) Alternative ID(s) of Target Chain 5 UniProt (TrEMBL) Submitted Name of Target Chain 5 UniProt (TrEMBL) Entry Name of Target Chain 5 UniProt (TrEMBL) Primary ID of Target Chain 5 UniProt (TrEMBL) Secondary ID(s) of Target Chain 5 UniProt (TrEMBL) Alternative ID(s) of Target Chain 5 BindingDB Target Chain Sequence 6 PDB ID(s) of Target Chain 6 UniProt (SwissProt) Recommended Name of Target Chain 6 UniProt (SwissProt) Entry Name of Target Chain 6 UniProt (SwissProt) Primary ID of Target Chain 6 UniProt (SwissProt) Secondary ID(s) of Target Chain 6 UniProt (SwissProt) Alternative ID(s) of Target Chain 6 UniProt (TrEMBL) Submitted Name of Target Chain 6 UniProt (TrEMBL) Entry Name of Target Chain 6 UniProt (TrEMBL) Primary ID of Target Chain 6 UniProt (TrEMBL) Secondary ID(s) of Target Chain 6 UniProt (TrEMBL) Alternative ID(s) of Target Chain 6 BindingDB Target Chain Sequence 7 PDB ID(s) of Target Chain 7 UniProt (SwissProt) Recommended Name of Target Chain 7 UniProt (SwissProt) Entry Name of Target Chain 7 UniProt (SwissProt) Primary ID of Target Chain 7 UniProt (SwissProt) Secondary ID(s) of Target Chain 7 UniProt (SwissProt) Alternative ID(s) of Target Chain 7 UniProt (TrEMBL) Submitted Name of Target Chain 7 UniProt (TrEMBL) Entry Name of Target Chain 7 UniProt (TrEMBL) Primary ID of Target Chain 7 UniProt (TrEMBL) Secondary ID(s) of Target Chain 7 UniProt (TrEMBL) Alternative ID(s) of Target Chain 7 BindingDB Target Chain Sequence 8 PDB ID(s) of Target Chain 8 UniProt (SwissProt) Recommended Name of Target Chain 8 UniProt (SwissProt) Entry Name of Target Chain 8 UniProt (SwissProt) Primary ID of Target Chain 8 UniProt (SwissProt) Secondary ID(s) of Target Chain 8 UniProt (SwissProt) Alternative ID(s) of Target Chain 8 UniProt (TrEMBL) Submitted Name of Target Chain 8 UniProt (TrEMBL) Entry Name of Target Chain 8 UniProt (TrEMBL) Primary ID of Target Chain 8 UniProt (TrEMBL) Secondary ID(s) of Target Chain 8 UniProt (TrEMBL) Alternative ID(s) of Target Chain 8 BindingDB Target Chain Sequence 9 PDB ID(s) of Target Chain 9 UniProt (SwissProt) Recommended Name of Target Chain 9 UniProt (SwissProt) Entry Name of Target Chain 9 UniProt (SwissProt) Primary ID of Target Chain 9 UniProt (SwissProt) Secondary ID(s) of Target Chain 9 UniProt (SwissProt) Alternative ID(s) of Target Chain 9 UniProt (TrEMBL) Submitted Name of Target Chain 9 UniProt (TrEMBL) Entry Name of Target Chain 9 UniProt (TrEMBL) Primary ID of Target Chain 9 UniProt (TrEMBL) Secondary ID(s) of Target Chain 9 UniProt (TrEMBL) Alternative ID(s) of Target Chain 9 BindingDB Target Chain Sequence 10 PDB ID(s) of Target Chain 10 UniProt (SwissProt) Recommended Name of Target Chain 10 UniProt (SwissProt) Entry Name of Target Chain 10 UniProt (SwissProt) Primary ID of Target Chain 10 UniProt (SwissProt) Secondary ID(s) of Target Chain 10 UniProt (SwissProt) Alternative ID(s) of Target Chain 10 UniProt (TrEMBL) Submitted Name of Target Chain 10 UniProt (TrEMBL) Entry Name of Target Chain 10 UniProt (TrEMBL) Primary ID of Target Chain 10 UniProt (TrEMBL) Secondary ID(s) of Target Chain 10 UniProt (TrEMBL) Alternative ID(s) of Target Chain 10 BindingDB Target Chain Sequence 11 PDB ID(s) of Target Chain 11 UniProt (SwissProt) Recommended Name of Target Chain 11 UniProt (SwissProt) Entry Name of Target Chain 11 UniProt (SwissProt) Primary ID of Target Chain 11 UniProt (SwissProt) Secondary ID(s) of Target Chain 11 UniProt (SwissProt) Alternative ID(s) of Target Chain 11 UniProt (TrEMBL) Submitted Name of Target Chain 11 UniProt (TrEMBL) Entry Name of Target Chain 11 UniProt (TrEMBL) Primary ID of Target Chain 11 UniProt (TrEMBL) Secondary ID(s) of Target Chain 11 UniProt (TrEMBL) Alternative ID(s) of Target Chain 11 BindingDB Target Chain Sequence 12 PDB ID(s) of Target Chain 12 UniProt (SwissProt) Recommended Name of Target Chain 12 UniProt (SwissProt) Entry Name of Target Chain 12 UniProt (SwissProt) Primary ID of Target Chain 12 UniProt (SwissProt) Secondary ID(s) of Target Chain 12 UniProt (SwissProt) Alternative ID(s) of Target Chain 12 UniProt (TrEMBL) Submitted Name of Target Chain 12 UniProt (TrEMBL) Entry Name of Target Chain 12 UniProt (TrEMBL) Primary ID of Target Chain 12 UniProt (TrEMBL) Secondary ID(s) of Target Chain 12 UniProt (TrEMBL) Alternative ID(s) of Target Chain 12 BindingDB Target Chain Sequence 13 PDB ID(s) of Target Chain 13 UniProt (SwissProt) Recommended Name of Target Chain 13 UniProt (SwissProt) Entry Name of Target Chain 13 UniProt (SwissProt) Primary ID of Target Chain 13 UniProt (SwissProt) Secondary ID(s) of Target Chain 13 UniProt (SwissProt) Alternative ID(s) of Target Chain 13 UniProt (TrEMBL) Submitted Name of Target Chain 13 UniProt (TrEMBL) Entry Name of Target Chain 13 UniProt (TrEMBL) Primary ID of Target Chain 13 UniProt (TrEMBL) Secondary ID(s) of Target Chain 13 UniProt (TrEMBL) Alternative ID(s) of Target Chain 13 BindingDB Target Chain Sequence 14 PDB ID(s) of Target Chain 14 UniProt (SwissProt) Recommended Name of Target Chain 14 UniProt (SwissProt) Entry Name of Target Chain 14 UniProt (SwissProt) Primary ID of Target Chain 14 UniProt (SwissProt) Secondary ID(s) of Target Chain 14 UniProt (SwissProt) Alternative ID(s) of Target Chain 14 UniProt (TrEMBL) Submitted Name of Target Chain 14 UniProt (TrEMBL) Entry Name of Target Chain 14 UniProt (TrEMBL) Primary ID of Target Chain 14 UniProt (TrEMBL) Secondary ID(s) of Target Chain 14 UniProt (TrEMBL) Alternative ID(s) of Target Chain 14 BindingDB Target Chain Sequence 15 PDB ID(s) of Target Chain 15 UniProt (SwissProt) Recommended Name of Target Chain 15 UniProt (SwissProt) Entry Name of Target Chain 15 UniProt (SwissProt) Primary ID of Target Chain 15 UniProt (SwissProt) Secondary ID(s) of Target Chain 15 UniProt (SwissProt) Alternative ID(s) of Target Chain 15 UniProt (TrEMBL) Submitted Name of Target Chain 15 UniProt (TrEMBL) Entry Name of Target Chain 15 UniProt (TrEMBL) Primary ID of Target Chain 15 UniProt (TrEMBL) Secondary ID(s) of Target Chain 15 UniProt (TrEMBL) Alternative ID(s) of Target Chain 15 BindingDB Target Chain Sequence 16 PDB ID(s) of Target Chain 16 UniProt (SwissProt) Recommended Name of Target Chain 16 UniProt (SwissProt) Entry Name of Target Chain 16 UniProt (SwissProt) Primary ID of Target Chain 16 UniProt (SwissProt) Secondary ID(s) of Target Chain 16 UniProt (SwissProt) Alternative ID(s) of Target Chain 16 UniProt (TrEMBL) Submitted Name of Target Chain 16 UniProt (TrEMBL) Entry Name of Target Chain 16 UniProt (TrEMBL) Primary ID of Target Chain 16 UniProt (TrEMBL) Secondary ID(s) of Target Chain 16 UniProt (TrEMBL) Alternative ID(s) of Target Chain 16 BindingDB Target Chain Sequence 17 PDB ID(s) of Target Chain 17 UniProt (SwissProt) Recommended Name of Target Chain 17 UniProt (SwissProt) Entry Name of Target Chain 17 UniProt (SwissProt) Primary ID of Target Chain 17 UniProt (SwissProt) Secondary ID(s) of Target Chain 17 UniProt (SwissProt) Alternative ID(s) of Target Chain 17 UniProt (TrEMBL) Submitted Name of Target Chain 17 UniProt (TrEMBL) Entry Name of Target Chain 17 UniProt (TrEMBL) Primary ID of Target Chain 17 UniProt (TrEMBL) Secondary ID(s) of Target Chain 17 UniProt (TrEMBL) Alternative ID(s) of Target Chain 17 BindingDB Target Chain Sequence 18 PDB ID(s) of Target Chain 18 UniProt (SwissProt) Recommended Name of Target Chain 18 UniProt (SwissProt) Entry Name of Target Chain 18 UniProt (SwissProt) Primary ID of Target Chain 18 UniProt (SwissProt) Secondary ID(s) of Target Chain 18 UniProt (SwissProt) Alternative ID(s) of Target Chain 18 UniProt (TrEMBL) Submitted Name of Target Chain 18 UniProt (TrEMBL) Entry Name of Target Chain 18 UniProt (TrEMBL) Primary ID of Target Chain 18 UniProt (TrEMBL) Secondary ID(s) of Target Chain 18 UniProt (TrEMBL) Alternative ID(s) of Target Chain 18 BindingDB Target Chain Sequence 19 PDB ID(s) of Target Chain 19 UniProt (SwissProt) Recommended Name of Target Chain 19 UniProt (SwissProt) Entry Name of Target Chain 19 UniProt (SwissProt) Primary ID of Target Chain 19 UniProt (SwissProt) Secondary ID(s) of Target Chain 19 UniProt (SwissProt) Alternative ID(s) of Target Chain 19 UniProt (TrEMBL) Submitted Name of Target Chain 19 UniProt (TrEMBL) Entry Name of Target Chain 19 UniProt (TrEMBL) Primary ID of Target Chain 19 UniProt (TrEMBL) Secondary ID(s) of Target Chain 19 UniProt (TrEMBL) Alternative ID(s) of Target Chain 19 BindingDB Target Chain Sequence 20 PDB ID(s) of Target Chain 20 UniProt (SwissProt) Recommended Name of Target Chain 20 UniProt (SwissProt) Entry Name of Target Chain 20 UniProt (SwissProt) Primary ID of Target Chain 20 UniProt (SwissProt) Secondary ID(s) of Target Chain 20 UniProt (SwissProt) Alternative ID(s) of Target Chain 20 UniProt (TrEMBL) Submitted Name of Target Chain 20 UniProt (TrEMBL) Entry Name of Target Chain 20 UniProt (TrEMBL) Primary ID of Target Chain 20 UniProt (TrEMBL) Secondary ID(s) of Target Chain 20 UniProt (TrEMBL) Alternative ID(s) of Target Chain 20 BindingDB Target Chain Sequence 21 PDB ID(s) of Target Chain 21 UniProt (SwissProt) Recommended Name of Target Chain 21 UniProt (SwissProt) Entry Name of Target Chain 21 UniProt (SwissProt) Primary ID of Target Chain 21 UniProt (SwissProt) Secondary ID(s) of Target Chain 21 UniProt (SwissProt) Alternative ID(s) of Target Chain 21 UniProt (TrEMBL) Submitted Name of Target Chain 21 UniProt (TrEMBL) Entry Name of Target Chain 21 UniProt (TrEMBL) Primary ID of Target Chain 21 UniProt (TrEMBL) Secondary ID(s) of Target Chain 21 UniProt (TrEMBL) Alternative ID(s) of Target Chain 21 BindingDB Target Chain Sequence 22 PDB ID(s) of Target Chain 22 UniProt (SwissProt) Recommended Name of Target Chain 22 UniProt (SwissProt) Entry Name of Target Chain 22 UniProt (SwissProt) Primary ID of Target Chain 22 UniProt (SwissProt) Secondary ID(s) of Target Chain 22 UniProt (SwissProt) Alternative ID(s) of Target Chain 22 UniProt (TrEMBL) Submitted Name of Target Chain 22 UniProt (TrEMBL) Entry Name of Target Chain 22 UniProt (TrEMBL) Primary ID of Target Chain 22 UniProt (TrEMBL) Secondary ID(s) of Target Chain 22 UniProt (TrEMBL) Alternative ID(s) of Target Chain 22 BindingDB Target Chain Sequence 23 PDB ID(s) of Target Chain 23 UniProt (SwissProt) Recommended Name of Target Chain 23 UniProt (SwissProt) Entry Name of Target Chain 23 UniProt (SwissProt) Primary ID of Target Chain 23 UniProt (SwissProt) Secondary ID(s) of Target Chain 23 UniProt (SwissProt) Alternative ID(s) of Target Chain 23 UniProt (TrEMBL) Submitted Name of Target Chain 23 UniProt (TrEMBL) Entry Name of Target Chain 23 UniProt (TrEMBL) Primary ID of Target Chain 23 UniProt (TrEMBL) Secondary ID(s) of Target Chain 23 UniProt (TrEMBL) Alternative ID(s) of Target Chain 23 BindingDB Target Chain Sequence 24 PDB ID(s) of Target Chain 24 UniProt (SwissProt) Recommended Name of Target Chain 24 UniProt (SwissProt) Entry Name of Target Chain 24 UniProt (SwissProt) Primary ID of Target Chain 24 UniProt (SwissProt) Secondary ID(s) of Target Chain 24 UniProt (SwissProt) Alternative ID(s) of Target Chain 24 UniProt (TrEMBL) Submitted Name of Target Chain 24 UniProt (TrEMBL) Entry Name of Target Chain 24 UniProt (TrEMBL) Primary ID of Target Chain 24 UniProt (TrEMBL) Secondary ID(s) of Target Chain 24 UniProt (TrEMBL) Alternative ID(s) of Target Chain 24 BindingDB Target Chain Sequence 25 PDB ID(s) of Target Chain 25 UniProt (SwissProt) Recommended Name of Target Chain 25 UniProt (SwissProt) Entry Name of Target Chain 25 UniProt (SwissProt) Primary ID of Target Chain 25 UniProt (SwissProt) Secondary ID(s) of Target Chain 25 UniProt (SwissProt) Alternative ID(s) of Target Chain 25 UniProt (TrEMBL) Submitted Name of Target Chain 25 UniProt (TrEMBL) Entry Name of Target Chain 25 UniProt (TrEMBL) Primary ID of Target Chain 25 UniProt (TrEMBL) Secondary ID(s) of Target Chain 25 UniProt (TrEMBL) Alternative ID(s) of Target Chain 25 BindingDB Target Chain Sequence 26 PDB ID(s) of Target Chain 26 UniProt (SwissProt) Recommended Name of Target Chain 26 UniProt (SwissProt) Entry Name of Target Chain 26 UniProt (SwissProt) Primary ID of Target Chain 26 UniProt (SwissProt) Secondary ID(s) of Target Chain 26 UniProt (SwissProt) Alternative ID(s) of Target Chain 26 UniProt (TrEMBL) Submitted Name of Target Chain 26 UniProt (TrEMBL) Entry Name of Target Chain 26 UniProt (TrEMBL) Primary ID of Target Chain 26 UniProt (TrEMBL) Secondary ID(s) of Target Chain 26 UniProt (TrEMBL) Alternative ID(s) of Target Chain 26 BindingDB Target Chain Sequence 27 PDB ID(s) of Target Chain 27 UniProt (SwissProt) Recommended Name of Target Chain 27 UniProt (SwissProt) Entry Name of Target Chain 27 UniProt (SwissProt) Primary ID of Target Chain 27 UniProt (SwissProt) Secondary ID(s) of Target Chain 27 UniProt (SwissProt) Alternative ID(s) of Target Chain 27 UniProt (TrEMBL) Submitted Name of Target Chain 27 UniProt (TrEMBL) Entry Name of Target Chain 27 UniProt (TrEMBL) Primary ID of Target Chain 27 UniProt (TrEMBL) Secondary ID(s) of Target Chain 27 UniProt (TrEMBL) Alternative ID(s) of Target Chain 27 BindingDB Target Chain Sequence 28 PDB ID(s) of Target Chain 28 UniProt (SwissProt) Recommended Name of Target Chain 28 UniProt (SwissProt) Entry Name of Target Chain 28 UniProt (SwissProt) Primary ID of Target Chain 28 UniProt (SwissProt) Secondary ID(s) of Target Chain 28 UniProt (SwissProt) Alternative ID(s) of Target Chain 28 UniProt (TrEMBL) Submitted Name of Target Chain 28 UniProt (TrEMBL) Entry Name of Target Chain 28 UniProt (TrEMBL) Primary ID of Target Chain 28 UniProt (TrEMBL) Secondary ID(s) of Target Chain 28 UniProt (TrEMBL) Alternative ID(s) of Target Chain 28 BindingDB Target Chain Sequence 29 PDB ID(s) of Target Chain 29 UniProt (SwissProt) Recommended Name of Target Chain 29 UniProt (SwissProt) Entry Name of Target Chain 29 UniProt (SwissProt) Primary ID of Target Chain 29 UniProt (SwissProt) Secondary ID(s) of Target Chain 29 UniProt (SwissProt) Alternative ID(s) of Target Chain 29 UniProt (TrEMBL) Submitted Name of Target Chain 29 UniProt (TrEMBL) Entry Name of Target Chain 29 UniProt (TrEMBL) Primary ID of Target Chain 29 UniProt (TrEMBL) Secondary ID(s) of Target Chain 29 UniProt (TrEMBL) Alternative ID(s) of Target Chain 29 BindingDB Target Chain Sequence 30 PDB ID(s) of Target Chain 30 UniProt (SwissProt) Recommended Name of Target Chain 30 UniProt (SwissProt) Entry Name of Target Chain 30 UniProt (SwissProt) Primary ID of Target Chain 30 UniProt (SwissProt) Secondary ID(s) of Target Chain 30 UniProt (SwissProt) Alternative ID(s) of Target Chain 30 UniProt (TrEMBL) Submitted Name of Target Chain 30 UniProt (TrEMBL) Entry Name of Target Chain 30 UniProt (TrEMBL) Primary ID of Target Chain 30 UniProt (TrEMBL) Secondary ID(s) of Target Chain 30 UniProt (TrEMBL) Alternative ID(s) of Target Chain 30 BindingDB Target Chain Sequence 31 PDB ID(s) of Target Chain 31 UniProt (SwissProt) Recommended Name of Target Chain 31 UniProt (SwissProt) Entry Name of Target Chain 31 UniProt (SwissProt) Primary ID of Target Chain 31 UniProt (SwissProt) Secondary ID(s) of Target Chain 31 UniProt (SwissProt) Alternative ID(s) of Target Chain 31 UniProt (TrEMBL) Submitted Name of Target Chain 31 UniProt (TrEMBL) Entry Name of Target Chain 31 UniProt (TrEMBL) Primary ID of Target Chain 31 UniProt (TrEMBL) Secondary ID(s) of Target Chain 31 UniProt (TrEMBL) Alternative ID(s) of Target Chain 31 BindingDB Target Chain Sequence 32 PDB ID(s) of Target Chain 32 UniProt (SwissProt) Recommended Name of Target Chain 32 UniProt (SwissProt) Entry Name of Target Chain 32 UniProt (SwissProt) Primary ID of Target Chain 32 UniProt (SwissProt) Secondary ID(s) of Target Chain 32 UniProt (SwissProt) Alternative ID(s) of Target Chain 32 UniProt (TrEMBL) Submitted Name of Target Chain 32 UniProt (TrEMBL) Entry Name of Target Chain 32 UniProt (TrEMBL) Primary ID of Target Chain 32 UniProt (TrEMBL) Secondary ID(s) of Target Chain 32 UniProt (TrEMBL) Alternative ID(s) of Target Chain 32 BindingDB Target Chain Sequence 33 PDB ID(s) of Target Chain 33 UniProt (SwissProt) Recommended Name of Target Chain 33 UniProt (SwissProt) Entry Name of Target Chain 33 UniProt (SwissProt) Primary ID of Target Chain 33 UniProt (SwissProt) Secondary ID(s) of Target Chain 33 UniProt (SwissProt) Alternative ID(s) of Target Chain 33 UniProt (TrEMBL) Submitted Name of Target Chain 33 UniProt (TrEMBL) Entry Name of Target Chain 33 UniProt (TrEMBL) Primary ID of Target Chain 33 UniProt (TrEMBL) Secondary ID(s) of Target Chain 33 UniProt (TrEMBL) Alternative ID(s) of Target Chain 33 BindingDB Target Chain Sequence 34 PDB ID(s) of Target Chain 34 UniProt (SwissProt) Recommended Name of Target Chain 34 UniProt (SwissProt) Entry Name of Target Chain 34 UniProt (SwissProt) Primary ID of Target Chain 34 UniProt (SwissProt) Secondary ID(s) of Target Chain 34 UniProt (SwissProt) Alternative ID(s) of Target Chain 34 UniProt (TrEMBL) Submitted Name of Target Chain 34 UniProt (TrEMBL) Entry Name of Target Chain 34 UniProt (TrEMBL) Primary ID of Target Chain 34 UniProt (TrEMBL) Secondary ID(s) of Target Chain 34 UniProt (TrEMBL) Alternative ID(s) of Target Chain 34 BindingDB Target Chain Sequence 35 PDB ID(s) of Target Chain 35 UniProt (SwissProt) Recommended Name of Target Chain 35 UniProt (SwissProt) Entry Name of Target Chain 35 UniProt (SwissProt) Primary ID of Target Chain 35 UniProt (SwissProt) Secondary ID(s) of Target Chain 35 UniProt (SwissProt) Alternative ID(s) of Target Chain 35 UniProt (TrEMBL) Submitted Name of Target Chain 35 UniProt (TrEMBL) Entry Name of Target Chain 35 UniProt (TrEMBL) Primary ID of Target Chain 35 UniProt (TrEMBL) Secondary ID(s) of Target Chain 35 UniProt (TrEMBL) Alternative ID(s) of Target Chain 35 BindingDB Target Chain Sequence 36 PDB ID(s) of Target Chain 36 UniProt (SwissProt) Recommended Name of Target Chain 36 UniProt (SwissProt) Entry Name of Target Chain 36 UniProt (SwissProt) Primary ID of Target Chain 36 UniProt (SwissProt) Secondary ID(s) of Target Chain 36 UniProt (SwissProt) Alternative ID(s) of Target Chain 36 UniProt (TrEMBL) Submitted Name of Target Chain 36 UniProt (TrEMBL) Entry Name of Target Chain 36 UniProt (TrEMBL) Primary ID of Target Chain 36 UniProt (TrEMBL) Secondary ID(s) of Target Chain 36 UniProt (TrEMBL) Alternative ID(s) of Target Chain 36 BindingDB Target Chain Sequence 37 PDB ID(s) of Target Chain 37 UniProt (SwissProt) Recommended Name of Target Chain 37 UniProt (SwissProt) Entry Name of Target Chain 37 UniProt (SwissProt) Primary ID of Target Chain 37 UniProt (SwissProt) Secondary ID(s) of Target Chain 37 UniProt (SwissProt) Alternative ID(s) of Target Chain 37 UniProt (TrEMBL) Submitted Name of Target Chain 37 UniProt (TrEMBL) Entry Name of Target Chain 37 UniProt (TrEMBL) Primary ID of Target Chain 37 UniProt (TrEMBL) Secondary ID(s) of Target Chain 37 UniProt (TrEMBL) Alternative ID(s) of Target Chain 37 BindingDB Target Chain Sequence 38 PDB ID(s) of Target Chain 38 UniProt (SwissProt) Recommended Name of Target Chain 38 UniProt (SwissProt) Entry Name of Target Chain 38 UniProt (SwissProt) Primary ID of Target Chain 38 UniProt (SwissProt) Secondary ID(s) of Target Chain 38 UniProt (SwissProt) Alternative ID(s) of Target Chain 38 UniProt (TrEMBL) Submitted Name of Target Chain 38 UniProt (TrEMBL) Entry Name of Target Chain 38 UniProt (TrEMBL) Primary ID of Target Chain 38 UniProt (TrEMBL) Secondary ID(s) of Target Chain 38 UniProt (TrEMBL) Alternative ID(s) of Target Chain 38 BindingDB Target Chain Sequence 39 PDB ID(s) of Target Chain 39 UniProt (SwissProt) Recommended Name of Target Chain 39 UniProt (SwissProt) Entry Name of Target Chain 39 UniProt (SwissProt) Primary ID of Target Chain 39 UniProt (SwissProt) Secondary ID(s) of Target Chain 39 UniProt (SwissProt) Alternative ID(s) of Target Chain 39 UniProt (TrEMBL) Submitted Name of Target Chain 39 UniProt (TrEMBL) Entry Name of Target Chain 39 UniProt (TrEMBL) Primary ID of Target Chain 39 UniProt (TrEMBL) Secondary ID(s) of Target Chain 39 UniProt (TrEMBL) Alternative ID(s) of Target Chain 39 BindingDB Target Chain Sequence 40 PDB ID(s) of Target Chain 40 UniProt (SwissProt) Recommended Name of Target Chain 40 UniProt (SwissProt) Entry Name of Target Chain 40 UniProt (SwissProt) Primary ID of Target Chain 40 UniProt (SwissProt) Secondary ID(s) of Target Chain 40 UniProt (SwissProt) Alternative ID(s) of Target Chain 40 UniProt (TrEMBL) Submitted Name of Target Chain 40 UniProt (TrEMBL) Entry Name of Target Chain 40 UniProt (TrEMBL) Primary ID of Target Chain 40 UniProt (TrEMBL) Secondary ID(s) of Target Chain 40 UniProt (TrEMBL) Alternative ID(s) of Target Chain 40 BindingDB Target Chain Sequence 41 PDB ID(s) of Target Chain 41 UniProt (SwissProt) Recommended Name of Target Chain 41 UniProt (SwissProt) Entry Name of Target Chain 41 UniProt (SwissProt) Primary ID of Target Chain 41 UniProt (SwissProt) Secondary ID(s) of Target Chain 41 UniProt (SwissProt) Alternative ID(s) of Target Chain 41 UniProt (TrEMBL) Submitted Name of Target Chain 41 UniProt (TrEMBL) Entry Name of Target Chain 41 UniProt (TrEMBL) Primary ID of Target Chain 41 UniProt (TrEMBL) Secondary ID(s) of Target Chain 41 UniProt (TrEMBL) Alternative ID(s) of Target Chain 41 BindingDB Target Chain Sequence 42 PDB ID(s) of Target Chain 42 UniProt (SwissProt) Recommended Name of Target Chain 42 UniProt (SwissProt) Entry Name of Target Chain 42 UniProt (SwissProt) Primary ID of Target Chain 42 UniProt (SwissProt) Secondary ID(s) of Target Chain 42 UniProt (SwissProt) Alternative ID(s) of Target Chain 42 UniProt (TrEMBL) Submitted Name of Target Chain 42 UniProt (TrEMBL) Entry Name of Target Chain 42 UniProt (TrEMBL) Primary ID of Target Chain 42 UniProt (TrEMBL) Secondary ID(s) of Target Chain 42 UniProt (TrEMBL) Alternative ID(s) of Target Chain 42 BindingDB Target Chain Sequence 43 PDB ID(s) of Target Chain 43 UniProt (SwissProt) Recommended Name of Target Chain 43 UniProt (SwissProt) Entry Name of Target Chain 43 UniProt (SwissProt) Primary ID of Target Chain 43 UniProt (SwissProt) Secondary ID(s) of Target Chain 43 UniProt (SwissProt) Alternative ID(s) of Target Chain 43 UniProt (TrEMBL) Submitted Name of Target Chain 43 UniProt (TrEMBL) Entry Name of Target Chain 43 UniProt (TrEMBL) Primary ID of Target Chain 43 UniProt (TrEMBL) Secondary ID(s) of Target Chain 43 UniProt (TrEMBL) Alternative ID(s) of Target Chain 43 BindingDB Target Chain Sequence 44 PDB ID(s) of Target Chain 44 UniProt (SwissProt) Recommended Name of Target Chain 44 UniProt (SwissProt) Entry Name of Target Chain 44 UniProt (SwissProt) Primary ID of Target Chain 44 UniProt (SwissProt) Secondary ID(s) of Target Chain 44 UniProt (SwissProt) Alternative ID(s) of Target Chain 44 UniProt (TrEMBL) Submitted Name of Target Chain 44 UniProt (TrEMBL) Entry Name of Target Chain 44 UniProt (TrEMBL) Primary ID of Target Chain 44 UniProt (TrEMBL) Secondary ID(s) of Target Chain 44 UniProt (TrEMBL) Alternative ID(s) of Target Chain 44 BindingDB Target Chain Sequence 45 PDB ID(s) of Target Chain 45 UniProt (SwissProt) Recommended Name of Target Chain 45 UniProt (SwissProt) Entry Name of Target Chain 45 UniProt (SwissProt) Primary ID of Target Chain 45 UniProt (SwissProt) Secondary ID(s) of Target Chain 45 UniProt (SwissProt) Alternative ID(s) of Target Chain 45 UniProt (TrEMBL) Submitted Name of Target Chain 45 UniProt (TrEMBL) Entry Name of Target Chain 45 UniProt (TrEMBL) Primary ID of Target Chain 45 UniProt (TrEMBL) Secondary ID(s) of Target Chain 45 UniProt (TrEMBL) Alternative ID(s) of Target Chain 45 BindingDB Target Chain Sequence 46 PDB ID(s) of Target Chain 46 UniProt (SwissProt) Recommended Name of Target Chain 46 UniProt (SwissProt) Entry Name of Target Chain 46 UniProt (SwissProt) Primary ID of Target Chain 46 UniProt (SwissProt) Secondary ID(s) of Target Chain 46 UniProt (SwissProt) Alternative ID(s) of Target Chain 46 UniProt (TrEMBL) Submitted Name of Target Chain 46 UniProt (TrEMBL) Entry Name of Target Chain 46 UniProt (TrEMBL) Primary ID of Target Chain 46 UniProt (TrEMBL) Secondary ID(s) of Target Chain 46 UniProt (TrEMBL) Alternative ID(s) of Target Chain 46 BindingDB Target Chain Sequence 47 PDB ID(s) of Target Chain 47 UniProt (SwissProt) Recommended Name of Target Chain 47 UniProt (SwissProt) Entry Name of Target Chain 47 UniProt (SwissProt) Primary ID of Target Chain 47 UniProt (SwissProt) Secondary ID(s) of Target Chain 47 UniProt (SwissProt) Alternative ID(s) of Target Chain 47 UniProt (TrEMBL) Submitted Name of Target Chain 47 UniProt (TrEMBL) Entry Name of Target Chain 47 UniProt (TrEMBL) Primary ID of Target Chain 47 UniProt (TrEMBL) Secondary ID(s) of Target Chain 47 UniProt (TrEMBL) Alternative ID(s) of Target Chain 47 BindingDB Target Chain Sequence 48 PDB ID(s) of Target Chain 48 UniProt (SwissProt) Recommended Name of Target Chain 48 UniProt (SwissProt) Entry Name of Target Chain 48 UniProt (SwissProt) Primary ID of Target Chain 48 UniProt (SwissProt) Secondary ID(s) of Target Chain 48 UniProt (SwissProt) Alternative ID(s) of Target Chain 48 UniProt (TrEMBL) Submitted Name of Target Chain 48 UniProt (TrEMBL) Entry Name of Target Chain 48 UniProt (TrEMBL) Primary ID of Target Chain 48 UniProt (TrEMBL) Secondary ID(s) of Target Chain 48 UniProt (TrEMBL) Alternative ID(s) of Target Chain 48 BindingDB Target Chain Sequence 49 PDB ID(s) of Target Chain 49 UniProt (SwissProt) Recommended Name of Target Chain 49 UniProt (SwissProt) Entry Name of Target Chain 49 UniProt (SwissProt) Primary ID of Target Chain 49 UniProt (SwissProt) Secondary ID(s) of Target Chain 49 UniProt (SwissProt) Alternative ID(s) of Target Chain 49 UniProt (TrEMBL) Submitted Name of Target Chain 49 UniProt (TrEMBL) Entry Name of Target Chain 49 UniProt (TrEMBL) Primary ID of Target Chain 49 UniProt (TrEMBL) Secondary ID(s) of Target Chain 49 UniProt (TrEMBL) Alternative ID(s) of Target Chain 49 BindingDB Target Chain Sequence 50 PDB ID(s) of Target Chain 50 UniProt (SwissProt) Recommended Name of Target Chain 50 UniProt (SwissProt) Entry Name of Target Chain 50 UniProt (SwissProt) Primary ID of Target Chain 50 UniProt (SwissProt) Secondary ID(s) of Target Chain 50 UniProt (SwissProt) Alternative ID(s) of Target Chain 50 UniProt (TrEMBL) Submitted Name of Target Chain 50 UniProt (TrEMBL) Entry Name of Target Chain 50 UniProt (TrEMBL) Primary ID of Target Chain 50 UniProt (TrEMBL) Secondary ID(s) of Target Chain 50 UniProt (TrEMBL) Alternative ID(s) of Target Chain 50 131557 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)nc2)c(=O)[nH]1 InChI=1S/C24H25N9O/c1-4-19(21-26-10-5-11-27-21)32(3)24-29-22-20(23(34)30-24)18(12-25)31-33(22)14(2)16-8-9-17(28-13-16)15-6-7-15/h5,8-11,13-15,19H,4,6-7H2,1-3H3,(H,29,30,34) JNOZSARLWIDZJL-UHFFFAOYSA-N 114715 US20260001888, Example 1 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 3.20 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114715 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114715&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 661662 252664196 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131558 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)nc2)c(=O)[nH]1 InChI=1S/C24H25N9O/c1-4-19(21-26-10-5-11-27-21)32(3)24-29-22-20(23(34)30-24)18(12-25)31-33(22)14(2)16-8-9-17(28-13-16)15-6-7-15/h5,8-11,13-15,19H,4,6-7H2,1-3H3,(H,29,30,34) JNOZSARLWIDZJL-UHFFFAOYSA-N 114717 US20260001888, Example 2 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 5.24 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114717 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114717&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2322533 252664198 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131559 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)nc2)c(=O)[nH]1 InChI=1S/C24H25N9O/c1-4-19(21-26-10-5-11-27-21)32(3)24-29-22-20(23(34)30-24)18(12-25)31-33(22)14(2)16-8-9-17(28-13-16)15-6-7-15/h5,8-11,13-15,19H,4,6-7H2,1-3H3,(H,29,30,34) JNOZSARLWIDZJL-UHFFFAOYSA-N 114718 US20260001888, Example 3 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 1.82 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114718 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114718&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 757874 252664199 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131560 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)nc2)c(=O)[nH]1 InChI=1S/C24H25N9O/c1-4-19(21-26-10-5-11-27-21)32(3)24-29-22-20(23(34)30-24)18(12-25)31-33(22)14(2)16-8-9-17(28-13-16)15-6-7-15/h5,8-11,13-15,19H,4,6-7H2,1-3H3,(H,29,30,34) JNOZSARLWIDZJL-UHFFFAOYSA-N 114719 US20260001888, Example 4 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.030 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114719 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114719&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 611239 252664200 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131561 CC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C21H18F3N9O/c1-11(13-5-6-15(28-10-13)21(22,23)24)33-18-16(14(9-25)31-33)19(34)30-20(29-18)32(3)12(2)17-26-7-4-8-27-17/h4-8,10-12H,1-3H3,(H,29,30,34) YPHURRUVLUJWPE-UHFFFAOYSA-N 114720 6-[methyl(1- pyrimidin-2- ylethyl)amino]- 4-oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 5 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 2.30 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114720 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114720&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 869136 252664201 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131562 CC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C21H18F3N9O/c1-11(13-5-6-15(28-10-13)21(22,23)24)33-18-16(14(9-25)31-33)19(34)30-20(29-18)32(3)12(2)17-26-7-4-8-27-17/h4-8,10-12H,1-3H3,(H,29,30,34) YPHURRUVLUJWPE-UHFFFAOYSA-N 114721 6-[methyl(1- pyrimidin-2- ylethyl)amino]- 4-oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 6 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 6.21 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114721 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114721&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 519224 252664202 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131563 CC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C21H18F3N9O/c1-11(13-5-6-15(28-10-13)21(22,23)24)33-18-16(14(9-25)31-33)19(34)30-20(29-18)32(3)12(2)17-26-7-4-8-27-17/h4-8,10-12H,1-3H3,(H,29,30,34) YPHURRUVLUJWPE-UHFFFAOYSA-N 114722 6-[methyl(1- pyrimidin-2- ylethyl)amino]- 4-oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 7 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 20.8 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114722 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114722&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 3551008 252664203 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131564 CC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C21H18F3N9O/c1-11(13-5-6-15(28-10-13)21(22,23)24)33-18-16(14(9-25)31-33)19(34)30-20(29-18)32(3)12(2)17-26-7-4-8-27-17/h4-8,10-12H,1-3H3,(H,29,30,34) YPHURRUVLUJWPE-UHFFFAOYSA-N 114723 6-[methyl(1- pyrimidin-2- ylethyl)amino]- 4-oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 8 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 243 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114723 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114723&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 217228 252664204 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131565 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C22H20F3N9O/c1-4-15(18-27-8-5-9-28-18)33(3)21-30-19-17(20(35)31-21)14(10-26)32-34(19)12(2)13-6-7-16(29-11-13)22(23,24)25/h5-9,11-12,15H,4H2,1-3H3,(H,30,31,35) RTLOBJPYHVQLHS-UHFFFAOYSA-N 114725 6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1-[1- [6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 9 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.140 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114725 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114725&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 867445 252664205 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131566 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C22H20F3N9O/c1-4-15(18-27-8-5-9-28-18)33(3)21-30-19-17(20(35)31-21)14(10-26)32-34(19)12(2)13-6-7-16(29-11-13)22(23,24)25/h5-9,11-12,15H,4H2,1-3H3,(H,30,31,35) RTLOBJPYHVQLHS-UHFFFAOYSA-N 114726 6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1-[1- [6-(trifluoro- methyl)-3- pyridyl]ethyl]- 5H-pyrazolo- [3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 10 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 9.98 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114726 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114726&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899727 252664206 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131567 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C22H20F3N9O/c1-4-15(18-27-8-5-9-28-18)33(3)21-30-19-17(20(35)31-21)14(10-26)32-34(19)12(2)13-6-7-16(29-11-13)22(23,24)25/h5-9,11-12,15H,4H2,1-3H3,(H,30,31,35) RTLOBJPYHVQLHS-UHFFFAOYSA-N 114727 6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1-[1- [6-(trifluoro- methyl)-3- pyridyl]ethyl]- 5H-pyrazolo- [3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 11 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 24.5 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114727 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114727&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5342491 252664207 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131568 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C22H20F3N9O/c1-4-15(18-27-8-5-9-28-18)33(3)21-30-19-17(20(35)31-21)14(10-26)32-34(19)12(2)13-6-7-16(29-11-13)22(23,24)25/h5-9,11-12,15H,4H2,1-3H3,(H,30,31,35) RTLOBJPYHVQLHS-UHFFFAOYSA-N 114728 6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1-[1- [6-(trifluoro- methyl)-3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 12 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 39.0 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114728 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114728&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 6858996 252664208 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131569 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)cc2)c(=O)[nH]1 InChI=1S/C23H21F3N8O/c1-4-17(19-28-10-5-11-29-19)33(3)22-30-20-18(21(35)31-22)16(12-27)32-34(20)13(2)14-6-8-15(9-7-14)23(24,25)26/h5-11,13,17H,4H2,1-3H3,(H,30,31,35) LFMRFSJRWDXDDE-UHFFFAOYSA-N 114729 6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1-[1- [4-(trifluoro- methyl)phenyl] ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 13 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 5.20 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114729 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114729&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2325130 252664209 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131570 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)cc2)c(=O)[nH]1 InChI=1S/C23H21F3N8O/c1-4-17(19-28-10-5-11-29-19)33(3)22-30-20-18(21(35)31-22)16(12-27)32-34(20)13(2)14-6-8-15(9-7-14)23(24,25)26/h5-11,13,17H,4H2,1-3H3,(H,30,31,35) LFMRFSJRWDXDDE-UHFFFAOYSA-N 114730 6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1-[1- [4-(trifluoro- methyl)phenyl] ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 14 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.010 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114730 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114730&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 3212603 252664210 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131571 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)cc2)c(=O)[nH]1 InChI=1S/C23H21F3N8O/c1-4-17(19-28-10-5-11-29-19)33(3)22-30-20-18(21(35)31-22)16(12-27)32-34(20)13(2)14-6-8-15(9-7-14)23(24,25)26/h5-11,13,17H,4H2,1-3H3,(H,30,31,35) LFMRFSJRWDXDDE-UHFFFAOYSA-N 114731 6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1-[1- [4-(trifluoro- methyl)phenyl] ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 15 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 2.82 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114731 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114731&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 7304501 252664211 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131572 CCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)cc2)c(=O)[nH]1 InChI=1S/C23H21F3N8O/c1-4-17(19-28-10-5-11-29-19)33(3)22-30-20-18(21(35)31-22)16(12-27)32-34(20)13(2)14-6-8-15(9-7-14)23(24,25)26/h5-11,13,17H,4H2,1-3H3,(H,30,31,35) LFMRFSJRWDXDDE-UHFFFAOYSA-N 114732 6-[methyl(1- pyrimidin-2- ylpropyl)amino]- 4-oxo-1-[1- [4-(trifluoro- methyl)phenyl] ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 16 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 11.1 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114732 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114732&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899728 252664212 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131573 CCC(c1ncc(C(F)F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H20F5N9O/c1-4-15(19-31-9-13(10-32-19)18(24)25)36(3)22-33-20-17(21(38)34-22)14(7-29)35-37(20)11(2)12-5-6-16(30-8-12)23(26,27)28/h5-6,8-11,15,18H,4H2,1-3H3,(H,33,34,38) KNKPDLQCIGATMX-UHFFFAOYSA-N 114733 6-[1-[5- (difluoromethyl) pyrimidin-2- yl]propyl- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3-pyridyl]- ethyl]-5H- pyrazolo[3,4- d]pyrimidine-3-carbonitrile::US20260001888, Example 17 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.010 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114733 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114733&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 6139089 252664213 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131574 CCC(c1ncc(C(F)F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H20F5N9O/c1-4-15(19-31-9-13(10-32-19)18(24)25)36(3)22-33-20-17(21(38)34-22)14(7-29)35-37(20)11(2)12-5-6-16(30-8-12)23(26,27)28/h5-6,8-11,15,18H,4H2,1-3H3,(H,33,34,38) KNKPDLQCIGATMX-UHFFFAOYSA-N 114734 6-[1-[5- (difluoromethyl) pyrimidin-2- yl]propyl- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4-d]pyrimidine-3-carbonitrile::US20260001888, Example 18 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 2.07 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114734 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114734&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 749848 252664214 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131575 CCC(c1ncc(C(F)F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H20F5N9O/c1-4-15(19-31-9-13(10-32-19)18(24)25)36(3)22-33-20-17(21(38)34-22)14(7-29)35-37(20)11(2)12-5-6-16(30-8-12)23(26,27)28/h5-6,8-11,15,18H,4H2,1-3H3,(H,33,34,38) KNKPDLQCIGATMX-UHFFFAOYSA-N 114735 6-[1-[5- (difluoromethyl) pyrimidin-2- yl]propyl- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3-pyridyl]- ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 19 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 7.36 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114735 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114735&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 845813 252664215 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131576 CCC(c1ncc(C(F)F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H20F5N9O/c1-4-15(19-31-9-13(10-32-19)18(24)25)36(3)22-33-20-17(21(38)34-22)14(7-29)35-37(20)11(2)12-5-6-16(30-8-12)23(26,27)28/h5-6,8-11,15,18H,4H2,1-3H3,(H,33,34,38) KNKPDLQCIGATMX-UHFFFAOYSA-N 114736 6-[1-[5- (difluoromethyl) pyrimidin-2- yl]propyl- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3-pyridyl]- ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 20 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 1.57 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114736 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114736&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899729 252664216 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131577 CC(C)C(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H22F3N9O/c1-12(2)18(19-28-8-5-9-29-19)34(4)22-31-20-17(21(36)32-22)15(10-27)33-35(20)13(3)14-6-7-16(30-11-14)23(24,25)26/h5-9,11-13,18H,1-4H3,(H,31,32,36) LMJABHMTZVCBME-UHFFFAOYSA-N 114737 6-[methyl-(2- methyl-1- pyrimidin-2- yl- propyl)amino]- 4-oxo-1-[1-[6- (trifluoromethyl)- 3-pyridyl]- ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 21 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 15.2 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114737 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114737&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 690223 252664217 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131578 CC(C)C(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H22F3N9O/c1-12(2)18(19-28-8-5-9-29-19)34(4)22-31-20-17(21(36)32-22)15(10-27)33-35(20)13(3)14-6-7-16(30-11-14)23(24,25)26/h5-9,11-13,18H,1-4H3,(H,31,32,36) LMJABHMTZVCBME-UHFFFAOYSA-N 114738 6-[methyl-(2- methyl-1- pyrimidin-2- yl- propyl)amino]- 4-oxo-1-[1-[6- (trifluoromethyl)- 3-pyridyl]- ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 22 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 6.50 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114738 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114738&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 817344 252664218 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131579 CC(C)C(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H22F3N9O/c1-12(2)18(19-28-8-5-9-29-19)34(4)22-31-20-17(21(36)32-22)15(10-27)33-35(20)13(3)14-6-7-16(30-11-14)23(24,25)26/h5-9,11-13,18H,1-4H3,(H,31,32,36) LMJABHMTZVCBME-UHFFFAOYSA-N 114739 6-[methyl-(2- methyl-1- pyrimidin-2- yl- propyl)amino]- 4-oxo-1-[1-[6- (trifluoromethyl)- 3-pyridyl]- ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 23 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.600 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114739 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114739&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search K3T 5MXV 2386708 252664219 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131580 CC(C)C(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H22F3N9O/c1-12(2)18(19-28-8-5-9-29-19)34(4)22-31-20-17(21(36)32-22)15(10-27)33-35(20)13(3)14-6-7-16(30-11-14)23(24,25)26/h5-9,11-13,18H,1-4H3,(H,31,32,36) LMJABHMTZVCBME-UHFFFAOYSA-N 114740 6-[methyl-(2- methyl-1- pyrimidin-2- yl- propyl)amino]- 4-oxo-1-[1-[6- (trifluoromethyl)- 3-pyridyl]- ethyl]-5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 24 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 69.2 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114740 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114740&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 6217008 252664220 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131581 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N(C)C(c3ncccn3)C3CC3)nc21 InChI=1S/C23H20F3N9O/c1-12(14-6-7-16(30-11-14)23(24,25)26)35-20-17(15(10-27)33-35)21(36)32-22(31-20)34(2)18(13-4-5-13)19-28-8-3-9-29-19/h3,6-9,11-13,18H,4-5H2,1-2H3,(H,31,32,36) SGEIGXFDVPNFOZ-UHFFFAOYSA-N 114742 6-[[cyclo- propyl(pyrimidin- 2- yl)methyl]- methyl- amino]-4-oxo- 1-[1-[6- (trifluoro- methyl)-3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 25 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 4.08 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114742 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114742&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5471247 252664221 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131582 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N(C)C(c3ncccn3)C3CC3)nc21 InChI=1S/C23H20F3N9O/c1-12(14-6-7-16(30-11-14)23(24,25)26)35-20-17(15(10-27)33-35)21(36)32-22(31-20)34(2)18(13-4-5-13)19-28-8-3-9-29-19/h3,6-9,11-13,18H,4-5H2,1-2H3,(H,31,32,36) SGEIGXFDVPNFOZ-UHFFFAOYSA-N 114743 6-[[cyclo- propyl(pyrimidin- 2- yl)methyl]- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 26 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 52.9 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114743 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114743&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5411098 252664222 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131583 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N(C)C(c3ncccn3)C3CC3)nc21 InChI=1S/C23H20F3N9O/c1-12(14-6-7-16(30-11-14)23(24,25)26)35-20-17(15(10-27)33-35)21(36)32-22(31-20)34(2)18(13-4-5-13)19-28-8-3-9-29-19/h3,6-9,11-13,18H,4-5H2,1-2H3,(H,31,32,36) SGEIGXFDVPNFOZ-UHFFFAOYSA-N 114744 6-[[cyclo- propyl(pyrimidin- 2- yl)methyl]- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 27 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 6.67 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114744 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114744&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 832119 252664223 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131584 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N(C)C(c3ncccn3)C3CC3)nc21 InChI=1S/C23H20F3N9O/c1-12(14-6-7-16(30-11-14)23(24,25)26)35-20-17(15(10-27)33-35)21(36)32-22(31-20)34(2)18(13-4-5-13)19-28-8-3-9-29-19/h3,6-9,11-13,18H,4-5H2,1-2H3,(H,31,32,36) SGEIGXFDVPNFOZ-UHFFFAOYSA-N 114745 6-[[cyclo- propyl(pyrimidin- 2- yl)methyl]- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 28 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 20.3 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114745 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114745&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 685576 252664224 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131585 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N(C)C(c3ncccn3)C3CCC3)nc21 InChI=1S/C24H22F3N9O/c1-13(15-7-8-17(31-12-15)24(25,26)27)36-21-18(16(11-28)34-36)22(37)33-23(32-21)35(2)19(14-5-3-6-14)20-29-9-4-10-30-20/h4,7-10,12-14,19H,3,5-6H2,1-2H3,(H,32,33,37) GLQNEPWKXKVDEF-UHFFFAOYSA-N 114746 6-[[cyclo- butyl(pyrimidin- 2-yl)methyl]- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- a]pyrimidine- 3-carbonitrile::US20260001888, Example 29 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 8.96 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114746 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114746&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2950184 252664225 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131586 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N(C)C(c3ncccn3)C3CCC3)nc21 InChI=1S/C24H22F3N9O/c1-13(15-7-8-17(31-12-15)24(25,26)27)36-21-18(16(11-28)34-36)22(37)33-23(32-21)35(2)19(14-5-3-6-14)20-29-9-4-10-30-20/h4,7-10,12-14,19H,3,5-6H2,1-2H3,(H,32,33,37) GLQNEPWKXKVDEF-UHFFFAOYSA-N 114747 6-[[cyclo- butyl(pyrimidin- 2-yl)methyl]- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- a]pyrimidine- 3-carbonitrile::US20260001888, Example 30 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 16.4 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114747 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114747&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 739034 252664226 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131587 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N(C)C(c3ncccn3)C3CCC3)nc21 InChI=1S/C24H22F3N9O/c1-13(15-7-8-17(31-12-15)24(25,26)27)36-21-18(16(11-28)34-36)22(37)33-23(32-21)35(2)19(14-5-3-6-14)20-29-9-4-10-30-20/h4,7-10,12-14,19H,3,5-6H2,1-2H3,(H,32,33,37) GLQNEPWKXKVDEF-UHFFFAOYSA-N 114748 6-[[cyclo- butyl(pyrimidin- 2-yl)methyl]- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- a]pyrimidine- 3-carbonitrile::US20260001888, Example 31 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 1.20 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114748 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114748&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 718728 252664227 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131588 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N(C)C(c3ncccn3)C3CCC3)nc21 InChI=1S/C24H22F3N9O/c1-13(15-7-8-17(31-12-15)24(25,26)27)36-21-18(16(11-28)34-36)22(37)33-23(32-21)35(2)19(14-5-3-6-14)20-29-9-4-10-30-20/h4,7-10,12-14,19H,3,5-6H2,1-2H3,(H,32,33,37) GLQNEPWKXKVDEF-UHFFFAOYSA-N 114750 6-[1-(5-fluoro- 2- pyridyl)propyl- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 32 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 40.5 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114750 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114750&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 761947 252664228 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131589 CCC(c1ccc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H20F4N8O/c1-4-17(15-7-6-14(24)11-29-15)34(3)22-31-20-19(21(36)32-22)16(9-28)33-35(20)12(2)13-5-8-18(30-10-13)23(25,26)27/h5-8,10-12,17H,4H2,1-3H3,(H,31,32,36) XFVQITMFAYTBLG-UHFFFAOYSA-N 114751 6-[1-(5-fluoro- 2- pyridyl)propyl- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3-pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 33 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.590 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114751 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114751&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 1160269 252664229 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131590 CCC(c1ccc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H20F4N8O/c1-4-17(15-7-6-14(24)11-29-15)34(3)22-31-20-19(21(36)32-22)16(9-28)33-35(20)12(2)13-5-8-18(30-10-13)23(25,26)27/h5-8,10-12,17H,4H2,1-3H3,(H,31,32,36) XFVQITMFAYTBLG-UHFFFAOYSA-N 114752 6-[1-(5-fluoro- 2- pyridyl)propyl- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3-pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 34 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.160 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114752 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114752&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 748227 252664230 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131591 CCC(c1ccc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H20F4N8O/c1-4-17(15-7-6-14(24)11-29-15)34(3)22-31-20-19(21(36)32-22)16(9-28)33-35(20)12(2)13-5-8-18(30-10-13)23(25,26)27/h5-8,10-12,17H,4H2,1-3H3,(H,31,32,36) XFVQITMFAYTBLG-UHFFFAOYSA-N 114753 6-[1-(5-fluoro- 2- pyridyl)propyl- methyl- amino]-4-oxo- 1-[1-[6- (trifluoromethyl)- 3-pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 35 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 7.12 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114753 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114753&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 960810 252664231 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131592 CCC(c1ccc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C23H20F4N8O/c1-4-17(15-7-6-14(24)11-29-15)34(3)22-31-20-19(21(36)32-22)16(9-28)33-35(20)12(2)13-5-8-18(30-10-13)23(25,26)27/h5-8,10-12,17H,4H2,1-3H3,(H,31,32,36) XFVQITMFAYTBLG-UHFFFAOYSA-N 114754 6-[1-(5-fluoro- 2-pyridyl)- propyl-methyl- amino]-4-oxo- 1-[1-[6- (trifluoro- methyl)-3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 36 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 19.9 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114754 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114754&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899730 252664232 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131593 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)C2CCOCC2)c(=O)[nH]1 InChI=1S/C21H25FN8O2/c1-4-16(18-24-10-14(22)11-25-18)29(3)21-26-19-17(20(31)27-21)15(9-23)28-30(19)12(2)13-5-7-32-8-6-13/h10-13,16H,4-8H2,1-3H3,(H,26,27,31) RFDANOPSGFXLNB-UHFFFAOYSA-N 114756 6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 1-(1- tetrahydropyran- 4-ylethyl)- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 37 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 2.67 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114756 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114756&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 3460648 252664233 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131594 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)C2CCOCC2)c(=O)[nH]1 InChI=1S/C21H25FN8O2/c1-4-16(18-24-10-14(22)11-25-18)29(3)21-26-19-17(20(31)27-21)15(9-23)28-30(19)12(2)13-5-7-32-8-6-13/h10-13,16H,4-8H2,1-3H3,(H,26,27,31) RFDANOPSGFXLNB-UHFFFAOYSA-N 114757 6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 1-(1- tetrahydropyran- 4-ylethyl)- 5H-pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 38 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 8.35 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114757 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114757&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 3454514 252664234 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131595 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)C2CCOCC2)c(=O)[nH]1 InChI=1S/C21H25FN8O2/c1-4-16(18-24-10-14(22)11-25-18)29(3)21-26-19-17(20(31)27-21)15(9-23)28-30(19)12(2)13-5-7-32-8-6-13/h10-13,16H,4-8H2,1-3H3,(H,26,27,31) RFDANOPSGFXLNB-UHFFFAOYSA-N 114758 6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 1-(1- tetrahydropyran- 4-ylethyl)- 5H-pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 39 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.170 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114758 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114758&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 3816222 252664235 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131596 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)C2CCOCC2)c(=O)[nH]1 InChI=1S/C21H25FN8O2/c1-4-16(18-24-10-14(22)11-25-18)29(3)21-26-19-17(20(31)27-21)15(9-23)28-30(19)12(2)13-5-7-32-8-6-13/h10-13,16H,4-8H2,1-3H3,(H,26,27,31) RFDANOPSGFXLNB-UHFFFAOYSA-N 114759 6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 1-(1- tetrahydropyran- 4-ylethyl)- 5H-pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 40 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 33.2 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114759 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114759&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 3817062 252664236 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131597 C=CCCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C24H22F3N9O/c1-4-5-7-17(20-29-10-6-11-30-20)35(3)23-32-21-19(22(37)33-23)16(12-28)34-36(21)14(2)15-8-9-18(31-13-15)24(25,26)27/h4,6,8-11,13-14,17H,1,5,7H2,2-3H3,(H,32,33,37) SSTLEANTIMQCHO-UHFFFAOYSA-N 114760 6-[methyl(1- pyrimidin-2- ylpent-4- enyl)amino]-4- oxo-1-[1-[6- (trifluoromethyl)- 3-pyridyl]ethyl]- 5H-pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 41 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.420 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114760 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114760&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 1489562 252664237 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131598 C=CCCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C24H22F3N9O/c1-4-5-7-17(20-29-10-6-11-30-20)35(3)23-32-21-19(22(37)33-23)16(12-28)34-36(21)14(2)15-8-9-18(31-13-15)24(25,26)27/h4,6,8-11,13-14,17H,1,5,7H2,2-3H3,(H,32,33,37) SSTLEANTIMQCHO-UHFFFAOYSA-N 114761 6-[methyl(1- pyrimidin-2- ylpent-4- enyl)amino]-4- oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 42 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 13.2 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114761 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114761&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 689669 252664238 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131599 C=CCCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C24H22F3N9O/c1-4-5-7-17(20-29-10-6-11-30-20)35(3)23-32-21-19(22(37)33-23)16(12-28)34-36(21)14(2)15-8-9-18(31-13-15)24(25,26)27/h4,6,8-11,13-14,17H,1,5,7H2,2-3H3,(H,32,33,37) SSTLEANTIMQCHO-UHFFFAOYSA-N 114762 6-[methyl(1- pyrimidin-2- ylpent-4- enyl)amino]-4- oxo-1-[1-[6- (trifluoromethyl)- 3-pyridyl]ethyl]- 5H-pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 43 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 38.8 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114762 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114762&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2321009 252664239 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131600 C=CCCC(c1ncccn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]1 InChI=1S/C24H22F3N9O/c1-4-5-7-17(20-29-10-6-11-30-20)35(3)23-32-21-19(22(37)33-23)16(12-28)34-36(21)14(2)15-8-9-18(31-13-15)24(25,26)27/h4,6,8-11,13-14,17H,1,5,7H2,2-3H3,(H,32,33,37) SSTLEANTIMQCHO-UHFFFAOYSA-N 114763 6-[methyl(1- pyrimidin-2- ylpent-4- enyl)amino]-4- oxo-1-[1-[6- (trifluoromethyl)- 3-pyridyl]ethyl]- 5H-pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 44 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 19.6 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114763 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114763&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 3585427 252664240 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131601 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ncccn3)nc21 InChI=1S/C21H16F3N9O/c1-11(12-3-4-15(28-10-12)21(22,23)24)33-18-16(13(9-25)31-33)19(34)30-20(29-18)32-8-5-14(32)17-26-6-2-7-27-17/h2-4,6-7,10-11,14H,5,8H2,1H3,(H,29,30,34) ZWWXYTMJWVKWLZ-UHFFFAOYSA-N 114764 4-oxo-6-(2- pyrimidin-2- ylazetidin-1- yl)-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 45 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.230 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114764 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114764&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899731 252664241 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131602 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ncccn3)nc21 InChI=1S/C21H16F3N9O/c1-11(12-3-4-15(28-10-12)21(22,23)24)33-18-16(13(9-25)31-33)19(34)30-20(29-18)32-8-5-14(32)17-26-6-2-7-27-17/h2-4,6-7,10-11,14H,5,8H2,1H3,(H,29,30,34) ZWWXYTMJWVKWLZ-UHFFFAOYSA-N 114765 4-oxo-6-(2- pyrimidin-2- ylazetidin-1- yl)-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 46 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 21.4 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114765 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114765&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899732 252664242 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131603 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ncccn3)nc21 InChI=1S/C21H16F3N9O/c1-11(12-3-4-15(28-10-12)21(22,23)24)33-18-16(13(9-25)31-33)19(34)30-20(29-18)32-8-5-14(32)17-26-6-2-7-27-17/h2-4,6-7,10-11,14H,5,8H2,1H3,(H,29,30,34) ZWWXYTMJWVKWLZ-UHFFFAOYSA-N 114766 4-oxo-6-(2- pyrimidin-2- ylazetidin-1- yl)-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 47 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 22.7 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114766 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114766&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2087887 252664243 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131604 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ncccn3)nc21 InChI=1S/C21H16F3N9O/c1-11(12-3-4-15(28-10-12)21(22,23)24)33-18-16(13(9-25)31-33)19(34)30-20(29-18)32-8-5-14(32)17-26-6-2-7-27-17/h2-4,6-7,10-11,14H,5,8H2,1H3,(H,29,30,34) ZWWXYTMJWVKWLZ-UHFFFAOYSA-N 114767 4-oxo-6-(2- pyrimidin-2- ylazetidin-1- yl)-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 48 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 17.4 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114767 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114767&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 571869 252664244 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131605 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ccc(F)cc3)nc21 InChI=1S/C23H17F4N7O/c1-12(14-4-7-18(29-11-14)23(25,26)27)34-20-19(16(10-28)32-34)21(35)31-22(30-20)33-9-8-17(33)13-2-5-15(24)6-3-13/h2-7,11-12,17H,8-9H2,1H3,(H,30,31,35) KNPCMEMRHYOKIN-UHFFFAOYSA-N 114768 6-[2-(4- fluorophenyl) azetidin-1-yl]-4- oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 49 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 22.7 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114768 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114768&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2316653 252664245 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131606 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ccc(F)cc3)nc21 InChI=1S/C23H17F4N7O/c1-12(14-4-7-18(29-11-14)23(25,26)27)34-20-19(16(10-28)32-34)21(35)31-22(30-20)33-9-8-17(33)13-2-5-15(24)6-3-13/h2-7,11-12,17H,8-9H2,1H3,(H,30,31,35) KNPCMEMRHYOKIN-UHFFFAOYSA-N 114770 6-[2-(4- fluorophenyl) azetidin-1-yl]-4- oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 50 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.600 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114770 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114770&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 594732 252664246 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131607 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ccc(F)cc3)nc21 InChI=1S/C23H17F4N7O/c1-12(14-4-7-18(29-11-14)23(25,26)27)34-20-19(16(10-28)32-34)21(35)31-22(30-20)33-9-8-17(33)13-2-5-15(24)6-3-13/h2-7,11-12,17H,8-9H2,1H3,(H,30,31,35) KNPCMEMRHYOKIN-UHFFFAOYSA-N 114771 6-[2-(4- fluorophenyl) azetidin-1-yl]-4- oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 51 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 7.41 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114771 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114771&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 828292 242053906 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131608 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ccc(F)cc3)nc21 InChI=1S/C23H17F4N7O/c1-12(14-4-7-18(29-11-14)23(25,26)27)34-20-19(16(10-28)32-34)21(35)31-22(30-20)33-9-8-17(33)13-2-5-15(24)6-3-13/h2-7,11-12,17H,8-9H2,1H3,(H,30,31,35) KNPCMEMRHYOKIN-UHFFFAOYSA-N 114772 6-[2-(4- fluorophenyl) azetidin-1-yl]-4- oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 52 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 6.70 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114772 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114772&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5419037 252664247 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131609 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCCC3c3ncccn3)nc21 InChI=1S/C22H18F3N9O/c1-12(13-5-6-16(29-11-13)22(23,24)25)34-19-17(14(10-26)32-34)20(35)31-21(30-19)33-9-2-4-15(33)18-27-7-3-8-28-18/h3,5-8,11-12,15H,2,4,9H2,1H3,(H,30,31,35) PYDHQGUFENFWBZ-UHFFFAOYSA-N 114773 4-oxo-6-(2- pyrimidin-2- ylpyrrolidin-1- yl)-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 53 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 207 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114773 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114773&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 267294 252664248 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131610 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCCC3c3ncccn3)nc21 InChI=1S/C22H18F3N9O/c1-12(13-5-6-16(29-11-13)22(23,24)25)34-19-17(14(10-26)32-34)20(35)31-21(30-19)33-9-2-4-15(33)18-27-7-3-8-28-18/h3,5-8,11-12,15H,2,4,9H2,1H3,(H,30,31,35) PYDHQGUFENFWBZ-UHFFFAOYSA-N 114775 4-oxo-6-(2- pyrimidin-2- ylpyrrolidin-1- yl)-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 54 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 6.53 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114775 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114775&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 6401658 252664249 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131611 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCCC3c3ncccn3)nc21 InChI=1S/C22H18F3N9O/c1-12(13-5-6-16(29-11-13)22(23,24)25)34-19-17(14(10-26)32-34)20(35)31-21(30-19)33-9-2-4-15(33)18-27-7-3-8-28-18/h3,5-8,11-12,15H,2,4,9H2,1H3,(H,30,31,35) PYDHQGUFENFWBZ-UHFFFAOYSA-N 114776 4-oxo-6-(2- pyrimidin-2- ylpyrrolidin-1- yl)-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 55 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 124 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114776 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114776&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 1201959 252664250 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131612 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCCC3c3ncccn3)nc21 InChI=1S/C22H18F3N9O/c1-12(13-5-6-16(29-11-13)22(23,24)25)34-19-17(14(10-26)32-34)20(35)31-21(30-19)33-9-2-4-15(33)18-27-7-3-8-28-18/h3,5-8,11-12,15H,2,4,9H2,1H3,(H,30,31,35) PYDHQGUFENFWBZ-UHFFFAOYSA-N 114777 4-oxo-6-(2- pyrimidin-2- ylpyrrolidin-1- yl)-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 56 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 289 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114777 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114777&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 4617342 252664251 C02125 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131613 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ccc(F)cc3)nc21 InChI=1S/C23H17F4N7O/c1-12(14-4-7-18(29-11-14)23(25,26)27)34-20-19(16(10-28)32-34)21(35)31-22(30-20)33-9-8-17(33)13-2-5-15(24)6-3-13/h2-7,11-12,17H,8-9H2,1H3,(H,30,31,35) KNPCMEMRHYOKIN-UHFFFAOYSA-N 114778 6-[2-(4- fluorophenyl) azetidin-1-yl]-4- oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 57 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 1.05 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114778 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114778&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2801704 252664252 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131614 CC(c1ccc(C(F)(F)F)nc1)n1nc(C#N)c2c(=O)[nH]c(N3CCC3c3ccc(F)cc3)nc21 InChI=1S/C23H17F4N7O/c1-12(14-4-7-18(29-11-14)23(25,26)27)34-20-19(16(10-28)32-34)21(35)31-22(30-20)33-9-8-17(33)13-2-5-15(24)6-3-13/h2-7,11-12,17H,8-9H2,1H3,(H,30,31,35) KNPCMEMRHYOKIN-UHFFFAOYSA-N 114780 6-[2-(4- fluorophenyl) azetidin-1-yl]-4- oxo-1-[1-[6- (trifluoromethyl)- 3- pyridyl]ethyl]- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 58 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 7.80 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114780 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114780&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 23640972 252664253 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131615 CCC(c1ncc(OC(F)(F)F)cn1)N(C)c4nc2c(c(C#N)nn2C(C)c3ccc(C(F)(F)F)nc3)c(=O)[nH]4 InChI=1S/C23H19F6N9O2/c1-4-15(18-32-9-13(10-33-18)40-23(27,28)29)37(3)21-34-19-17(20(39)35-21)14(7-30)36-38(19)11(2)12-5-6-16(31-8-12)22(24,25)26/h5-6,8-11,15H,4H2,1-3H3,(H,34,35,39) PAHDTWXLOVMLFA-UHFFFAOYSA-N 114781 6-[methyl-[1- [5-(trifluoro- methoxy) pyrimidin-2- yl]propyl]amino]- 4-oxo-1-[1- [6-(trifluoro- methyl)-3- pyridyl]ethyl]- 5H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile::US20260001888, Example 59 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 12.1 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114781 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114781&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5381405 252664254 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131616 CCC(c1ncc(OC(F)(F)F)cn1)N(C)c4nc2c(c(C#N)nn2C(C)c3ccc(C(F)(F)F)nc3)c(=O)[nH]4 InChI=1S/C23H19F6N9O2/c1-4-15(18-32-9-13(10-33-18)40-23(27,28)29)37(3)21-34-19-17(20(39)35-21)14(7-30)36-38(19)11(2)12-5-6-16(31-8-12)22(24,25)26/h5-6,8-11,15H,4H2,1-3H3,(H,34,35,39) PAHDTWXLOVMLFA-UHFFFAOYSA-N 114782 6-[methyl-[1- [5-(trifluoro- methoxy) pyrimidin-2- yl]propyl]amino]- 4-oxo-1-[1- [6-(trifluoro- methyl)-3- pyridyl]ethyl]- 5H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile::US20260001888, Example 60 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 1.06 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114782 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114782&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 828167 252664255 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131617 CCC(c1ncc(OC(F)(F)F)cn1)N(C)c4nc2c(c(C#N)nn2C(C)c3ccc(C(F)(F)F)nc3)c(=O)[nH]4 InChI=1S/C23H19F6N9O2/c1-4-15(18-32-9-13(10-33-18)40-23(27,28)29)37(3)21-34-19-17(20(39)35-21)14(7-30)36-38(19)11(2)12-5-6-16(31-8-12)22(24,25)26/h5-6,8-11,15H,4H2,1-3H3,(H,34,35,39) PAHDTWXLOVMLFA-UHFFFAOYSA-N 114783 6-[methyl-[1- [5-(trifluoro- methoxy) pyrimidin-2- yl]propyl]- amino]-4-oxo- 1-[1-[6- (trifluoro- methyl)-3- pyridyl]ethyl]-5H-pyrazolo-d]pyrimidine-3-carbonitrile::US20260001888, Example 61 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.170 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114783 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114783&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899733 252664256 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131618 CCC(c1ncc(OC(F)(F)F)cn1)N(C)c4nc2c(c(C#N)nn2C(C)c3ccc(C(F)(F)F)nc3)c(=O)[nH]4 InChI=1S/C23H19F6N9O2/c1-4-15(18-32-9-13(10-33-18)40-23(27,28)29)37(3)21-34-19-17(20(39)35-21)14(7-30)36-38(19)11(2)12-5-6-16(31-8-12)22(24,25)26/h5-6,8-11,15H,4H2,1-3H3,(H,34,35,39) PAHDTWXLOVMLFA-UHFFFAOYSA-N 114784 6-[methyl-[1- [5-(trifluoro- methoxy) pyrimidin-2- yl]propyl]amino]- 4-oxo-1-[1- [6-(trifluoro- methyl)-3- pyridyl]ethyl]- 5H-pyrazolo[3,4-d]pyrimidine-3-carbonitrile::US20260001888, Example 62 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 50.7 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114784 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114784&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5726794 252664257 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131619 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)nc2)c(=O)[nH]1 InChI=1S/C24H24FN9O/c1-4-19(21-28-11-16(25)12-29-21)33(3)24-30-22-20(23(35)31-24)18(9-26)32-34(22)13(2)15-7-8-17(27-10-15)14-5-6-14/h7-8,10-14,19H,4-6H2,1-3H3,(H,30,31,35) HIFAHJMYPWLBMK-UHFFFAOYSA-N 114785 1-[1-(6- cyclopropyl-3- pyridyl)ethyl]- 6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 5H- pyrazolo[3,4- d]pyrimidine-3-carbonitrile::US20260001888, Example 63 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 14.8 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114785 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114785&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 23723216 252664258 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131620 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)nc2)c(=O)[nH]1 InChI=1S/C24H24FN9O/c1-4-19(21-28-11-16(25)12-29-21)33(3)24-30-22-20(23(35)31-24)18(9-26)32-34(22)13(2)15-7-8-17(27-10-15)14-5-6-14/h7-8,10-14,19H,4-6H2,1-3H3,(H,30,31,35) HIFAHJMYPWLBMK-UHFFFAOYSA-N 114786 1-[1-(6- cyclopropyl-3- pyridyl)ethyl]- 6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 5H- pyrazolo[3,4- d]pyrimidine-3-carbonitrile::US20260001888, Example 64 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 11.9 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114786 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114786&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 6895732 252664259 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131621 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)nc2)c(=O)[nH]1 InChI=1S/C24H24FN9O/c1-4-19(21-28-11-16(25)12-29-21)33(3)24-30-22-20(23(35)31-24)18(9-26)32-34(22)13(2)15-7-8-17(27-10-15)14-5-6-14/h7-8,10-14,19H,4-6H2,1-3H3,(H,30,31,35) HIFAHJMYPWLBMK-UHFFFAOYSA-N 114787 1-[1-(6- cyclopropyl-3- pyridyl)ethyl]- 6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 65 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.030 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114787 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114787&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899734 252664260 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131622 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)nc2)c(=O)[nH]1 InChI=1S/C24H24FN9O/c1-4-19(21-28-11-16(25)12-29-21)33(3)24-30-22-20(23(35)31-24)18(9-26)32-34(22)13(2)15-7-8-17(27-10-15)14-5-6-14/h7-8,10-14,19H,4-6H2,1-3H3,(H,30,31,35) HIFAHJMYPWLBMK-UHFFFAOYSA-N 114788 1-[1-(6- cyclopropyl-3- pyridyl)ethyl]- 6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 66 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.600 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114788 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114788&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5405580 252664261 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131623 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)cc2)c(=O)[nH]1 InChI=1S/C25H25FN8O/c1-4-20(22-28-12-18(26)13-29-22)33(3)25-30-23-21(24(35)31-25)19(11-27)32-34(23)14(2)15-5-7-16(8-6-15)17-9-10-17/h5-8,12-14,17,20H,4,9-10H2,1-3H3,(H,30,31,35) IHWSRSPDNBEWBV-UHFFFAOYSA-N 114789 1-[1-(4- cyclopropylphenyl) ethyl]-6- [1-(5-fluoro- pyrimidin-2- yl)propyl- methyl- amino]-4-oxo- 5H- pyrazolo[3,4- d]pyrimidine-3-carbonitrile::US20260001888, Example 67 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.710 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114789 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114789&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 732122 252664262 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131624 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)cc2)c(=O)[nH]1 InChI=1S/C25H25FN8O/c1-4-20(22-28-12-18(26)13-29-22)33(3)25-30-23-21(24(35)31-25)19(11-27)32-34(23)14(2)15-5-7-16(8-6-15)17-9-10-17/h5-8,12-14,17,20H,4,9-10H2,1-3H3,(H,30,31,35) IHWSRSPDNBEWBV-UHFFFAOYSA-N 114791 1-[1-(4- cyclopropylphenyl) ethyl]-6- [1-(5-fluoro- pyrimidin-2- yl)propyl- methyl- amino]-4-oxo- 5H- pyrazolo[3,4- d]pyrimidine-3-carbonitrile::US20260001888, Example 68 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.730 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114791 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114791&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 91899735 252664264 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131625 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)cc2)c(=O)[nH]1 InChI=1S/C25H25FN8O/c1-4-20(22-28-12-18(26)13-29-22)33(3)25-30-23-21(24(35)31-25)19(11-27)32-34(23)14(2)15-5-7-16(8-6-15)17-9-10-17/h5-8,12-14,17,20H,4,9-10H2,1-3H3,(H,30,31,35) IHWSRSPDNBEWBV-UHFFFAOYSA-N 114792 1-[1-(4- cyclopropylphenyl) ethyl]-6- [1-(5-fluoro- pyrimidin-2- yl)propyl- methyl- amino]-4-oxo- 5H- pyrazolo[3,4- d]pyrimidine-3-carbonitrile::US20260001888, Example 69 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 14.9 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114792 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114792&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 972993 252664265 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131626 CCC(c1ncc(F)cn1)N(C)c1nc2c(c(C#N)nn2C(C)c2ccc(C3CC3)cc2)c(=O)[nH]1 InChI=1S/C25H25FN8O/c1-4-20(22-28-12-18(26)13-29-22)33(3)25-30-23-21(24(35)31-25)19(11-27)32-34(23)14(2)15-5-7-16(8-6-15)17-9-10-17/h5-8,12-14,17,20H,4,9-10H2,1-3H3,(H,30,31,35) IHWSRSPDNBEWBV-UHFFFAOYSA-N 114793 1-[1-(4-cyclo- propylphenyl) ethyl]-6-[1-(5- fluoropyrimidin- 2-yl)propyl- methyl- amino]-4-oxo- 5H- pyrazolo[3,4- d]pyrimidine- 3-carbonitrile::US20260001888, Example 70 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.020 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114793 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114793&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 972914 252664266 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131627 CCC(Nc1nc2c(c(C#N)nn2C(C)C2C=NC(C(F)(F)F)=CC2)c(=O)[nH]1)c1ncccn1 InChI=1S/C21H20F3N9O/c1-3-13(17-26-7-4-8-27-17)29-20-30-18-16(19(34)31-20)14(9-25)32-33(18)11(2)12-5-6-15(28-10-12)21(22,23)24/h4,6-8,10-13H,3,5H2,1-2H3,(H2,29,30,31,34) OAWHNJFKJXBJJZ-UHFFFAOYSA-N 114794 US20260001888, Example 71 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 11.8 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114794 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114794&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5800217 252664267 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131628 CCC(Nc1nc2c(c(C#N)nn2C(C)C2C=NC(C(F)(F)F)=CC2)c(=O)[nH]1)c1ncccn1 InChI=1S/C21H20F3N9O/c1-3-13(17-26-7-4-8-27-17)29-20-30-18-16(19(34)31-20)14(9-25)32-33(18)11(2)12-5-6-15(28-10-12)21(22,23)24/h4,6-8,10-13H,3,5H2,1-2H3,(H2,29,30,31,34) OAWHNJFKJXBJJZ-UHFFFAOYSA-N 114795 US20260001888, Example 72 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 21.9 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114795 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114795&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 677565 252664268 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131629 CCC(Nc1nc2c(c(C#N)nn2C(C)C2C=NC(C(F)(F)F)=CC2)c(=O)[nH]1)c1ncccn1 InChI=1S/C21H20F3N9O/c1-3-13(17-26-7-4-8-27-17)29-20-30-18-16(19(34)31-20)14(9-25)32-33(18)11(2)12-5-6-15(28-10-12)21(22,23)24/h4,6-8,10-13H,3,5H2,1-2H3,(H2,29,30,31,34) OAWHNJFKJXBJJZ-UHFFFAOYSA-N 114796 US20260001888, Example 73 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.250 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114796 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114796&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 755477 252664269 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131630 CCC(Nc1nc2c(c(C#N)nn2C(C)C2C=NC(C(F)(F)F)=CC2)c(=O)[nH]1)c1ncccn1 InChI=1S/C21H20F3N9O/c1-3-13(17-26-7-4-8-27-17)29-20-30-18-16(19(34)31-20)14(9-25)32-33(18)11(2)12-5-6-15(28-10-12)21(22,23)24/h4,6-8,10-13H,3,5H2,1-2H3,(H2,29,30,31,34) OAWHNJFKJXBJJZ-UHFFFAOYSA-N 114797 US20260001888, Example 74 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 11.4 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114797 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114797&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5338754 252664270 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131631 CCC(C1=NCC(F)C=N1)N(C)C1NC(=O)c2c(C#N)nn(C(C)C3C=NC(C(F)(F)F)=CC3)c2N1 InChI=1S/C22H25F4N9O/c1-4-15(18-29-9-13(23)10-30-18)34(3)21-31-19-17(20(36)32-21)14(7-27)33-35(19)11(2)12-5-6-16(28-8-12)22(24,25)26/h6,8-9,11-13,15,21,31H,4-5,10H2,1-3H3,(H,32,36) MNANUOFOASSSGT-UHFFFAOYSA-N 114798 US20260001888, Example 75 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 3.31 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114798 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114798&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 4035462 252664271 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131632 CCC(C1=NCC(F)C=N1)N(C)C1NC(=O)c2c(C#N)nn(C(C)C3C=NC(C(F)(F)F)=CC3)c2N1 InChI=1S/C22H25F4N9O/c1-4-15(18-29-9-13(23)10-30-18)34(3)21-31-19-17(20(36)32-21)14(7-27)33-35(19)11(2)12-5-6-16(28-8-12)22(24,25)26/h6,8-9,11-13,15,21,31H,4-5,10H2,1-3H3,(H,32,36) MNANUOFOASSSGT-UHFFFAOYSA-N 114799 US20260001888, Example 76 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 55.1 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114799 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114799&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 616375 252664272 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131633 CCC(C1=NCC(F)C=N1)N(C)C1NC(=O)c2c(C#N)nn(C(C)C3C=NC(C(F)(F)F)=CC3)c2N1 InChI=1S/C22H25F4N9O/c1-4-15(18-29-9-13(23)10-30-18)34(3)21-31-19-17(20(36)32-21)14(7-27)33-35(19)11(2)12-5-6-16(28-8-12)22(24,25)26/h6,8-9,11-13,15,21,31H,4-5,10H2,1-3H3,(H,32,36) MNANUOFOASSSGT-UHFFFAOYSA-N 114800 US20260001888, Example 77 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.270 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114800 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114800&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5286407 252664273 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131634 CCC(C1=NCC(F)C=N1)N(C)C1NC(=O)c2c(C#N)nn(C(C)C3C=NC(C(F)(F)F)=CC3)c2N1 InChI=1S/C22H25F4N9O/c1-4-15(18-29-9-13(23)10-30-18)34(3)21-31-19-17(20(36)32-21)14(7-27)33-35(19)11(2)12-5-6-16(28-8-12)22(24,25)26/h6,8-9,11-13,15,21,31H,4-5,10H2,1-3H3,(H,32,36) MNANUOFOASSSGT-UHFFFAOYSA-N 114801 US20260001888, Example 78 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 34.2 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114801 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114801&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 1259900 252664274 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131635 C[C@H](C1C=NC(C(F)(F)F)=CC1)n4nc(C#N)c3c(=O)[nH]c(CCc2ncccn2)nc34 InChI=1S/C20H17F3N8O/c1-11(12-3-4-14(27-10-12)20(21,22)23)31-18-17(13(9-24)30-31)19(32)29-16(28-18)6-5-15-25-7-2-8-26-15/h2,4,7-8,10-12H,3,5-6H2,1H3,(H,28,29,32) MQRHJNANERCYAI-UHFFFAOYSA-N 114802 US20260001888, Example 79 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 3.96 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114802 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114802&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 22510376 252664275 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131636 C[C@@H](C1C=NC(C(F)(F)F)=CC1)n4nc(C#N)c3c(=O)[nH]c(CCc2ncccn2)nc34 InChI=1S/C20H17F3N8O/c1-11(12-3-4-14(27-10-12)20(21,22)23)31-18-17(13(9-24)30-31)19(32)29-16(28-18)6-5-15-25-7-2-8-26-15/h2,4,7-8,10-12H,3,5-6H2,1H3,(H,28,29,32) MQRHJNANERCYAI-UHFFFAOYSA-N 114803 US20260001888, Example 80 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 120 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114803 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114803&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5714039 252664276 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131637 C[C@H](C1C=NC(C(F)(F)F)=CC1)n5nc(C#N)c4C(=O)NC(CCC3=NCC(C2CC2)C=N3)Nc45 InChI=1S/C23H25F3N8O/c1-12(14-4-5-17(28-9-14)23(24,25)26)34-21-20(16(8-27)33-34)22(35)32-19(31-21)7-6-18-29-10-15(11-30-18)13-2-3-13/h5,9-10,12-15,19,31H,2-4,6-7,11H2,1H3,(H,32,35) SRJKJVSSCFRYIA-UHFFFAOYSA-N 114805 US20260001888, Example 81 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.500 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114805 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114805&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2092383 252664277 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131638 C[C@@H](C1C=NC(C(F)(F)F)=CC1)n5nc(C#N)c4C(=O)NC(CCC3=NCC(C2CC2)C=N3)Nc45 InChI=1S/C23H25F3N8O/c1-12(14-4-5-17(28-9-14)23(24,25)26)34-21-20(16(8-27)33-34)22(35)32-19(31-21)7-6-18-29-10-15(11-30-18)13-2-3-13/h5,9-10,12-15,19,31H,2-4,6-7,11H2,1H3,(H,32,35) SRJKJVSSCFRYIA-UHFFFAOYSA-N 114806 US20260001888, Example 82 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 16.2 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114806 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114806&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 4463708 252664278 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131639 CC(Cc3nc1c(c(C#N)nn1C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]3)c4ncccn4 InChI=1S/C21H17F3N8O/c1-11(18-26-6-3-7-27-18)8-16-29-19-17(20(33)30-16)14(9-25)31-32(19)12(2)13-4-5-15(28-10-13)21(22,23)24/h3-7,10-12H,8H2,1-2H3,(H,29,30,33) ZGSSGKLJCJOFIK-UHFFFAOYSA-N 114808 4-oxo-6-(2- (pyrimidin-2- yl)propyl)-1-(1- (6- (trifluoromethyl) pyridin-3- yl)ethyl)-4,5- dihydro-1H- pyrazolo[3,4- d]pyrimidine-3- carbonitrile::US20260001888, Example 83 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 60.7 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114808 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114808&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2804214 252664279 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131640 CC(Cc3nc1c(c(C#N)nn1C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]3)c4ncccn4 InChI=1S/C21H17F3N8O/c1-11(18-26-6-3-7-27-18)8-16-29-19-17(20(33)30-16)14(9-25)31-32(19)12(2)13-4-5-15(28-10-13)21(22,23)24/h3-7,10-12H,8H2,1-2H3,(H,29,30,33) ZGSSGKLJCJOFIK-UHFFFAOYSA-N 114809 4-oxo-6-(2- (pyrimidin-2- yl)propyl)-1-(1- (6- (trifluoromethyl) pyridin-3- yl)ethyl)-4,5- dihydro-1H- pyrazolo[3,4- d]pyrimidine-3- carbonitrile::US20260001888, Example 84 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 112 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114809 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114809&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 1093868 252664280 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131641 CC(Cc3nc1c(c(C#N)nn1C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]3)c4ncccn4 InChI=1S/C21H17F3N8O/c1-11(18-26-6-3-7-27-18)8-16-29-19-17(20(33)30-16)14(9-25)31-32(19)12(2)13-4-5-15(28-10-13)21(22,23)24/h3-7,10-12H,8H2,1-2H3,(H,29,30,33) ZGSSGKLJCJOFIK-UHFFFAOYSA-N 114810 4-oxo-6-(2- (pyrimidin-2- yl)propyl)-1-(1- (6- (trifluoromethyl) pyridin-3- yl)ethyl)-4,5- dihydro-1H- pyrazolo[3,4- d]pyrimidine-3- carbonitrile::US20260001888, Example 85 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 1.17 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114810 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114810&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 5938646 252664281 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131642 CC(Cc3nc1c(c(C#N)nn1C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]3)c4ncccn4 InChI=1S/C21H17F3N8O/c1-11(18-26-6-3-7-27-18)8-16-29-19-17(20(33)30-16)14(9-25)31-32(19)12(2)13-4-5-15(28-10-13)21(22,23)24/h3-7,10-12H,8H2,1-2H3,(H,29,30,33) ZGSSGKLJCJOFIK-UHFFFAOYSA-N 114811 4-oxo-6-(2- (pyrimidin-2- yl)propyl)-1-(1- (6- (trifluoromethyl) pyridin-3- yl)ethyl)-4,5- dihydro-1H- pyrazolo[3,4- d]pyrimidine-3- carbonitrile::US20260001888, Example 86 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 33.4 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114811 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114811&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 768734 252664282 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131643 CCC(Cc3nc1c(c(C#N)nn1C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]3)c4ncccn4 InChI=1S/C22H19F3N8O/c1-3-13(19-27-7-4-8-28-19)9-17-30-20-18(21(34)31-17)15(10-26)32-33(20)12(2)14-5-6-16(29-11-14)22(23,24)25/h4-8,11-13H,3,9H2,1-2H3,(H,30,31,34) MQQWYVBTRXBANK-UHFFFAOYSA-N 114812 4-oxo-6-(2- (pyrimidin-2- yl)butyl)-1-(1-(6- (trifluoromethyl) pyridin-3- yl)ethyl)-4,5- dihydro-1H- pyrazolo[3,4- d]pyrimidine-3- carbonitrile::US20260001888, Example 87 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 93.4 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114812 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114812&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 24818579 252664283 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131644 CCC(Cc3nc1c(c(C#N)nn1C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]3)c4ncccn4 InChI=1S/C22H19F3N8O/c1-3-13(19-27-7-4-8-28-19)9-17-30-20-18(21(34)31-17)15(10-26)32-33(20)12(2)14-5-6-16(29-11-14)22(23,24)25/h4-8,11-13H,3,9H2,1-2H3,(H,30,31,34) MQQWYVBTRXBANK-UHFFFAOYSA-N 114813 4-oxo-6-(2- (pyrimidin-2- yl)butyl)-1-(1-(6- (trifluoromethyl) pyridin-3- yl)ethyl)-4,5- dihydro-1H- pyrazolo[3,4- d]pyrimidine-3- carbonitrile::US20260001888, Example 88 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 108 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114813 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114813&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 16382764 252664284 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131645 CCC(Cc3nc1c(c(C#N)nn1C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]3)c4ncccn4 InChI=1S/C22H19F3N8O/c1-3-13(19-27-7-4-8-28-19)9-17-30-20-18(21(34)31-17)15(10-26)32-33(20)12(2)14-5-6-16(29-11-14)22(23,24)25/h4-8,11-13H,3,9H2,1-2H3,(H,30,31,34) MQQWYVBTRXBANK-UHFFFAOYSA-N 114814 4-oxo-6-(2- (pyrimidin-2- yl)butyl)-1-(1-(6- (trifluoromethyl) pyridin-3- yl)ethyl)-4,5- dihydro-1H- pyrazolo[3,4- d]pyrimidine-3- carbonitrile::US20260001888, Example 89 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 0.240 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114814 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114814&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 2814043 252664285 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0 131646 CCC(Cc3nc1c(c(C#N)nn1C(C)c2ccc(C(F)(F)F)nc2)c(=O)[nH]3)c4ncccn4 InChI=1S/C22H19F3N8O/c1-3-13(19-27-7-4-8-28-19)9-17-30-20-18(21(34)31-17)15(10-26)32-33(20)12(2)14-5-6-16(29-11-14)22(23,24)25/h4-8,11-13H,3,9H2,1-2H3,(H,30,31,34) MQQWYVBTRXBANK-UHFFFAOYSA-N 114815 4-oxo-6-(2- (pyrimidin-2- yl)butyl)-1-(1-(6- (trifluoromethyl) pyridin-3- yl)ethyl)-4,5- dihydro-1H- pyrazolo[3,4- d]pyrimidine-3- carbonitrile::US20260001888, Example 90 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A Homo sapiens 28.0 US Patent 10.7270/Q2RX9HW1 US20260001888 ARASAPPAN, A; COX, JM; DEBENHAM, JS; FENG, Z; GUO, Z; MENG, D 1/1/2026 5/13/2026 Merck Sharp & Dohme http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=114815 http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=pol&polymerid=5068&target=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/rwd/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=114815&enzyme=High+affinity+cGMP-specific+3%27%2C5%27-cyclic+phosphodiesterase+9A&column=ki&startPg=0&Increment=50&submit=Search 7770823 252664286 1 MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA 2YY2,4GH6,3K3H,3K3E,2HD1,4G2L,4G2J,4E90,3JSW,3JSI,3DYS,3DYQ,3DYN,3DYL,3DY8,6LZZ,6A3N,8BPY High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A PDE9A_HUMAN O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0